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49 results on '"Jarvik, Robert"'

7. Is the New Infant Jarvik 2015 Suitable for Patients<8 kg? In Vitro Study Using a Hybrid Simulator

Author

Di Molfetta, Arianna, Zielinski, Krzysztof, Ferrari, Gianfranco, Kozarski, Macej, Okrzeja, Piotr, Iacobelli, Roberta, Filippelli, Sergio, Perri, Gianluigi, Darowski, Marek, Massetti, Massimo, Jarvik, Robert, Amodeo, Antonio, Massetti, Massimo (ORCID:0000-0002-7100-8478), Di Molfetta, Arianna, Zielinski, Krzysztof, Ferrari, Gianfranco, Kozarski, Macej, Okrzeja, Piotr, Iacobelli, Roberta, Filippelli, Sergio, Perri, Gianluigi, Darowski, Marek, Massetti, Massimo, Jarvik, Robert, Amodeo, Antonio, and Massetti, Massimo (ORCID:0000-0002-7100-8478)

Abstract

Our aim was to study the feasibility of implanting the Infant Jarvik 2015 in patients weighing less than 8 kg. The Infant Jarvik 2015 left ventricular assist device (LVAD) was tested in a hybrid simulator of the cardiovascular system reproducing specific patients’ hemodynamics for different patient weights (2–7 kg). For each weight, the sensitivity of the pump to different circulatory parameters (peripheral resistance, left ventricular elastance, right ventricular elastance, heart rate, and heart filling characteristics) has been tested repeating for each experiment a pump ramp (10 000–18 000 rpm). The increase in the pump speed causes a decrease (increase) in the left (right) atrial pressure, an increase (decrease) in the arterial systemic (pulmonary) pressure, an increase in the right ventricular pressure, a decrease (increase) in the left (right) ventricular volume, a decrease in the left ventricular cardiac output, an increase in the LVAD output and an increase in the right ventricular cardiac output (total cardiac output). Suction was observed for lower weight patients and for higher pump speed in the case of vasodilation, left ventricular recovery, bradycardia, right ventricular failure, and left ventricular hypertrophy. Backflow was observed in the case of left ventricular recovery at lower pump speed. In the hybrid simulator, the Infant Jarvik 2015 could be suitable for the implantation in patients lower than 8 kg because of the stability of the device respect to the cardio/circulatory changes (low frequency of suction and backflow) and because of the capability of the device to maintain adequate patient hemodynamics.

Published
2019

9. First permanent implant of the Jarvik 2000 Heart

Author

Westaby, Stephen, Banning, Adrian P, Jarvik, Robert, Frazier, O H, Pigott, David W, Jin, Xu Y, Catarino, Pedro A, Saito, Satoshi, Robson, Desirée, Freeland, Andrew, Myers, Timothy J, and Poole-Wilson, Philip A

Published
2000

12. Is the New Infant Jarvik 2015 Suitable for Patients<8 kg? In Vitro Study Using a Hybrid Simulator

Author

Di Molfetta, Arianna, primary, Zielinski, Krzysztof, additional, Ferrari, Gianfranco, additional, Kozarski, Macej, additional, Okrzeja, Piotr, additional, Iacobelli, Roberta, additional, Filippelli, Sergio, additional, Perri, Gianluigi, additional, Darowski, Marek, additional, Massetti, Massimo, additional, Jarvik, Robert, additional, and Amodeo, Antonio, additional

Published
2018
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14. The miniaturized pediatric continuous-flow device: Preclinical assessment in the chronic sheep model

Author

Adachi, Iki, primary, Burki, Sarah, additional, Horne, David, additional, Costas, Gil G., additional, Spangler, Taylor, additional, Jarvik, Robert, additional, Teal, John, additional, Baldwin, J. Timothy, additional, Dasse, Kurt, additional, Massicotte, M. Patricia, additional, Conger, Jeff, additional, Cohn, William E., additional, and Fraser, Charles D., additional

Published
2017
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15. Closing in on the PumpKIN Trial of the Jarvik 2015 Ventricular Assist Device

Author

Baldwin, J. Timothy, primary, Adachi, Iki, additional, Teal, John, additional, Almond, Christopher A., additional, Jaquiss, Robert D., additional, Massicotte, M. Patricia, additional, Dasse, Kurt, additional, Siami, Flora S., additional, Zak, Victor, additional, Kaltman, Jonathan R., additional, Mahle, William T., additional, and Jarvik, Robert, additional

Published
2017
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21. Mechanical Reliability of the Jarvik 2000 Heart

Author

Siegenthaler, Michael P., primary, Frazier, O.H., additional, Beyersdorf, Friedhelm, additional, Martin, Jürgen, additional, Laks, Hillel, additional, Elefteriades, John, additional, Khaghani, Asghar, additional, Kjellman, Ulf, additional, Koul, Bansi, additional, Pepper, John, additional, Jarvik, Robert, additional, and Westaby, Stephen, additional

Published
2006
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31. Circulatory Support for Long-Term Treatment of Heart Failure

Author

Westaby, Stephen, primary, Banning, Adrian P., additional, Saito, Satoshi, additional, Pigott, David W., additional, Jin, Xu Y., additional, Catarino, Pedro A., additional, Robson, Desiree, additional, Moorjani, Narain, additional, Kardos, Attila, additional, Poole-Wilson, Philip A., additional, Jarvik, Robert, additional, and Frazier, O.H., additional

Published
2002
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33. Jarvik 2000 Heart

Author

Westaby, Stephen, primary, Katsumata, Takahiro, additional, Houel, Remi, additional, Evans, Rhys, additional, Pigott, David, additional, Frazier, O. H., additional, and Jarvik, Robert, additional

Published
1998
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34. Rotary Pumps New Developments and Future Perspectives

Author

NOSAE, YUKIHIKO, primary, TSUTSUI, TATSUO, additional, BUTLER, KENNETH C., additional, JARVIK, ROBERT, additional, TAKAMI, YOSHIYUKI, additional, NOJIRI, CHISATO, additional, ALLAIRE, PAUL, additional, RAMM, OLAF VON, additional, and DOW, JERRY, additional

Published
1998
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43. In VivoExperience of the Child-Size Pediatric Jarvik 2000 Heart Update

Author

Gibber, Marc, Wu, Zhongjun J., Chang, Won-Bae, Bianchi, Giacomo, Hu, Jingping, Garcia, Jose, Jarvik, Robert, and Griffith, Bartley P.

Abstract

Data from early in vivoexperiments demonstrated that the child-size Jarvik heart was capable of providing partial to nearly complete circulatory support with acceptable adverse effects on blood. However, bearing thrombosis was responsible for device malfunction in most cases. To overcome this problem, original pin bearings were replaced with novel conical bearings. This study evaluated chronic in vivoperformance of the modified child-size Jarvik heart in the pediatric setting. Six juvenile sheep were implanted with the modified child-size Jarvik heart. Cardiac and pump output were measured daily. Serial blood samples were drawn to evaluate hematology, biocompatibility, and end-organ function. End-organ damage and device thrombosis were examined at necropsy. No device malfunction occurred during animal experiments up to 70 days. Mean cardiac output of the animals was 3.4 L/min. The child-size Jarvik heart was able to deliver a blood flow ranging from 1.4 to 2.5 L/min at speed from 10,000 rpm to 14,000 rpm. Mean plasma-free hemoglobin was 9.8 ± 5.6 mg/dl, indicating no hemolysis. Acute elevation occurred in some organ function tests after the implant surgery but returned to normal range thereafter. These indices and necropsy showed no end-organ damage. No device thrombosis was observed. The current in vivoexperience shows that the modified child Jarvik 2000 heart retained its hemodynamic function and excellent biocompatibility, and the conical bearings permitted it to remain free of thrombus.

Published
2010
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44. Six-month survival of a calf with an artificial heart

Author

Lawson, John H., Fukumasu, Hiroyuki, Olsen, Don B., Jarvik, Robert K., Kessler, Thomas R., Coleman, Dennis, Pons, A.B., Blaylock, Robert, and Kolff, W.J.

Abstract

A pneumatically powered artificial heart, constructed primarily from a polyurethane, was implanted in the chest of a calf and supported the calf for more than 6 months. The heart, which was designed to fit in the chest of a 90 kilogram calf, was able to support the animal when it weighed 180 kilograms. During the first 105 days the calf remained strong and healthy. The animal grew progressively weaker after day 105, and by day 160 right heart failure became apparent. The principal cause of the right heart failure was an obstructive growth between the right atrium and the right ventricle. An attempt to correct the problem on day 184 with an artificial heart resulted in the animal’s death.

Published
1979
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47. Willem Kolff.

Author

Jarvik, Robert

Subjects
KOLFF, Willem
Abstract

An obituary for Dr. Willem Kolff, one of the founders of the American Society for Artificial Internal Organs, is presented.

Published
2009

48. Face the nation. Sunday, November 11, 1984

Author

CBS News Productions, production company., Vitarelli, Robert E., director., Altman, Lawrence K., interviewee., Bayer, Ronald, interviewee., Jarvik, Robert, 1946- interviewee., Provonsha, Jack W., interviewee., Doroshow, Robin W., interviewee., Stahl, Lesley, on-screen presenter, interviewer., and Sughrue, Karen M., producer.

Published
1984

49. Is the New Infant Jarvik 2015 Suitable for Patients<8 kg? In Vitro Study Using a Hybrid Simulator.

Author

Di Molfetta A, Zielinski K, Ferrari G, Kozarski M, Okrzeja P, Iacobelli R, Filippelli S, Perri G, Darowski M, Massetti M, Jarvik R, and Amodeo A

Subjects
Feasibility Studies, Humans, Infant, Infant, Newborn, Reproducibility of Results, Body Weight, Heart-Assist Devices standards, Hemodynamics, Models, Biological, Prosthesis Implantation standards
Abstract

Our aim was to study the feasibility of implanting the Infant Jarvik 2015 in patients weighing less than 8 kg. The Infant Jarvik 2015 left ventricular assist device (LVAD) was tested in a hybrid simulator of the cardiovascular system reproducing specific patients' hemodynamics for different patient weights (2-7 kg). For each weight, the sensitivity of the pump to different circulatory parameters (peripheral resistance, left ventricular elastance, right ventricular elastance, heart rate, and heart filling characteristics) has been tested repeating for each experiment a pump ramp (10 000-18 000 rpm). The increase in the pump speed causes a decrease (increase) in the left (right) atrial pressure, an increase (decrease) in the arterial systemic (pulmonary) pressure, an increase in the right ventricular pressure, a decrease (increase) in the left (right) ventricular volume, a decrease in the left ventricular cardiac output, an increase in the LVAD output and an increase in the right ventricular cardiac output (total cardiac output). Suction was observed for lower weight patients and for higher pump speed in the case of vasodilation, left ventricular recovery, bradycardia, right ventricular failure, and left ventricular hypertrophy. Backflow was observed in the case of left ventricular recovery at lower pump speed. In the hybrid simulator, the Infant Jarvik 2015 could be suitable for the implantation in patients lower than 8 kg because of the stability of the device respect to the cardio/circulatory changes (low frequency of suction and backflow) and because of the capability of the device to maintain adequate patient hemodynamics., (© 2018 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.)

Published
2019
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