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256 results on '"Jaron, Dov"'

3. A Food in Health Security (FIHS) Platform in the Asia-Pacific Region: The Way Forward

Author

Wahlqvist, Mark L, Keatinge, John Donough H, Butler, Colin D, Friel, Sharon, McKay, John, Easdown, Warwick, Kuo, Ken N, Huang, Ching-Jang, Pan, Wen-Harn, Yang, Ray-Yu, Lee, Meei-Shyuan, Chang, Hsing-Yi, Chiu, Ya-Wen, Jaron, Dov, Krawinkel, Michael, Barlow, Snow, Walsh, Greg, Chiang, Tung-Liang, Huang, Po-Chao, and Li, Duo

Published
2009

14. Equal Oxygen Delivery May Not Result in Equal Oxygen Consumption

Author

Ye, Guo-Fan, Jöbsis-VanderVliet, Frans F., Jöbsis, Paul D., Dubin, Stephen E., Shi, Wenyao, Jaron, Dov, Nemoto, Edwin M., editor, LaManna, Joseph C., editor, Cooper, Christopher, editor, Delpy, David, editor, Groebe, Karlfried, editor, Hunt, Thomas K., editor, Keipert, Peter, editor, Mayevsky, Avrahim, editor, Pittman, Roland N., editor, Rumsey, William L., editor, Vaupel, Peter, editor, and Wilson, David F., editor

Published
1997
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15. Influence of O2-Hb Kinetics and the Fähraeus Effect on the Arteriolar Role in Gas Exchange

Author

Ye, Guo-Fan, Buerk, Donald G., Ye, Lei, Jaron, Dov, Nemoto, Edwin M., editor, LaManna, Joseph C., editor, Cooper, Christopher, editor, Delpy, David, editor, Groebe, Karlfried, editor, Hunt, Thomas K., editor, Keipert, Peter, editor, Mayevsky, Avrahim, editor, Pittman, Roland N., editor, Rumsey, William L., editor, Vaupel, Peter, editor, and Wilson, David F., editor

Published
1997
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19. Comparing Model Simulation and Experimental Results to Study the Dependence on Shear Stress of NO, ATP and ADP Production from Endothelial Cells

Author

Jaron, Dov, Kirby, Patrick, Barbee, Kenneth A., Parikh, Jaimit, Buerk, Donald G., Magjarevic, Ratko, Editor-in-chief, Ładyżyński, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Kyriacou, Efthyvoulos, editor, Christofides, Stelios, editor, and Pattichis, Constantinos S., editor

Published
2016
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21. Transport-dependent calcium signaling in spatially segregated cellular caveolar domains

Author

Hong, Dihui, Jaron, Dov, Buerk, Donald G., and Barbee, Kenneth A.

Subjects
Caveolae -- Properties, Biological transport -- Evaluation, Cellular signal transduction -- Evaluation, Cell membranes -- Properties, Endothelium -- Properties, Nitric oxide -- Health aspects, Calcium channels -- Properties, Biological sciences
Abstract

We developed a two-dimensional model of transport-dependent intracellular calcium signaling in endothelial cells (ECs). Our purpose was to evaluate the effects of spatial colocalization of endothelial nitric oxide synthase (eNOS) and capacitative calcium entry (CCE) channels in caveolae on eNOS activation in response to ATP. Caveolae are specialized microdomains of the plasma membrane that contain a variety of signaling molecules to optimize their interactions and regulate their activity. In ECs, these molecules include CCE channels and eNOS. To achieve a quantitative understanding of the mechanisms of microdomain calcium signaling and the preferential sensitivity of eNOS to calcium entering the cell through CCE channels, we constructed a mathematical model incorporating the cell morphology and cellular physiological processes. The model predicts that the spatial segregation of calcium channels in ECs can create transport-dependent sharp gradients in calcium concentration within the cell. The calcium concentration gradient is affected by channel density and cell geometry. This transport-dependent calcium signaling specificity effect is enhanced in ECs by increasing the spatial segregation of the caveolar signaling domains. Our simulation significantly advances the understanding of how [Ca.sup.2+], despite its many potential actions, can mediate selective activation of signaling pathways. We show that diffusion-limited calcium transport allows functional compartmentalization of signaling pathways based on the spatial arrangements of [Ca.sup.2+] sources and targets. capacitative calcium entry; caveolae; endothelial cells: endothelial nitric oxide synthase; mathematical model

Published
2008

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