19 results on '"Jara, José Antonio"'
Search Results
2. Origanum vulgare L. essential oil inhibits virulence patterns of Candida spp. and potentiates the effects of fluconazole and nystatin in vitro
- Author
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Cid-Chevecich, Camila, Müller-Sepúlveda, Andrea, Jara, José Antonio, López-Muñoz, Rodrigo, Santander, Rocío, Budini, Mauricio, Escobar, Alejandro, Quijada, Raúl, Criollo, Alfredo, Díaz-Dosque, Mario, and Molina-Berríos, Alfredo
- Published
- 2022
- Full Text
- View/download PDF
3. Antimigratory Effect of Lipophilic Cations Derived from Gallic and Gentisic Acid and Synergistic Effect with 5-Fluorouracil on Metastatic Colorectal Cancer Cells: A New Synthesis Route.
- Author
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Suárez-Rozas, Cristian, Jara, José Antonio, Cortés, Gonzalo, Rojas, Diego, Araya-Valdés, Gabriel, Molina-Berrios, Alfredo, González-Herrera, Fabiola, Fuentes-Retamal, Sebastián, Aránguiz-Urroz, Pablo, Campodónico, Paola Rossana, Maya, Juan Diego, Vivar, Raúl, and Catalán, Mabel
- Subjects
- *
CELL migration inhibition , *IN vitro studies , *CELL migration , *VASCULAR endothelial growth factors , *MITOCHONDRIA , *RESEARCH funding , *APOPTOSIS , *COLORECTAL cancer , *CELLULAR signal transduction , *AMP-activated protein kinases , *REVERSE transcriptase polymerase chain reaction , *DESCRIPTIVE statistics , *METASTASIS , *CELL lines , *PLANT extracts , *CELL culture , *CYTOTOXINS , *PHENOLS , *MOLECULAR structure , *ORGANOPHOSPHORUS compounds , *MICROBIOLOGICAL assay , *WESTERN immunoblotting , *MATRIX metalloproteinases , *ONE-way analysis of variance , *FLUOROURACIL , *CELL survival , *DATA analysis software , *DISEASE progression - Abstract
Simple Summary: Colorectal cancer (CRC) is one of the most common causes of death worldwide. Today, this disease does not have an effective treatment, leading to the exploration of novel pharmacological molecules. In this paper, we design and synthesize with a new synthetic route the lipophilic cation derived from gallic acid (TPP+C10) and gentisic acid (GA-TPP+C10), both able to reach mitochondria and uncouple the electron transport chain. Our results show that combining 5-fluorouracil with GA-TPP+C10 has a synergistic cytotoxic effect on CRC cells. Both compounds show antimigratory effects, decreasing signaling pathways and biomarkers. Our results show that mitochondrial agents could be an alternative to standard CRC drugs against this disease. Colorectal cancer (CRC) is the third leading cause of cancer deaths in the world. Standard drugs currently used for the treatment of advanced CRC—such as 5-fluorouracil (5FU)—remain unsatisfactory in their results due to their high toxicity, high resistance, and adverse effects. In recent years, mitochondria have become an attractive target for cancer therapy due to higher transmembrane mitochondrial potential. We synthesized gallic acid derivatives linked to a ten-carbon aliphatic chain associated with triphenylphosphonium (TPP+C10), a lipophilic cationic molecule that induces the uncoupling of the electron transport chain (ETC). Other derivatives, such as gentisic acid (GA-TPP+C10), have the same effects on colorectal cancer cells. Although part of our group had previously reported preparing these structures by a convergent synthesis route, including their application via flow chemistry, there was no precedent for a new methodology for preparing these compounds. In this scenario, this study aims to develop a new linear synthesis strategy involving an essential step of Steglich esterification under mild conditions (open flask) and a high degree of reproducibility. Moreover, the study seeks to associate GA-TPP+C10 with 5FU to evaluate synergistic antineoplastic effects. In addition, we assess the antimigratory effect of GA-TPP+C10 and TPP+C10 using human and mouse metastatic CRC cell lines. The results show a new and efficient synthesis route of these compounds, having synergistic effects in combination with 5FU, increasing apoptosis and enhancing cytotoxic properties. Additionally, the results show a robust antimigratory effect of GATPP+C10 and TPP+C10, reducing the activation pathways linked to tumor progression and reducing the expression of VEGF and MMP-2 and MMP-9, common biomarkers of advanced CRC. Moreover, TPP+C10 and GA-TPP+C10 increase the activity of metabolic signaling pathways through AMPK activation. The data allow us to conclude that these compounds can be used for in vivo evaluations and are a promising alternative associated with conventional therapies for advanced colorectal cancer. Additionally, the reported intermediates of the new synthesis route could give rise to analog compounds with improved therapeutic activity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. Chapter 18. Fiscal Attitudes and Practices and the Construction of Identity in Late Medieval Cuenca
- Author
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Jara, José Antonio, primary
- Published
- 2021
- Full Text
- View/download PDF
5. FISCAL ATTITUDES AND PRACTICES AND THE CONSTRUCTION OF IDENTITY IN LATE MEDIEVAL CUENCA
- Author
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JARA, JOSÉ ANTONIO, primary
- Published
- 2021
- Full Text
- View/download PDF
6. Multi-technique approach to rockfall monitoring in the Montserrat massif (Catalonia, NE Spain)
- Author
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Janeras, Marc, Jara, José-Antonio, Royán, Manuel J., Vilaplana, Joan-Manuel, Aguasca, Albert, Fàbregas, Xavier, Gili, Josep A., and Buxó, Pere
- Published
- 2017
- Full Text
- View/download PDF
7. Red de estaciones de medida de parámetros físicos del suelo
- Author
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Boquera,Lola, Lladós,Agnès, and Jara,José Antonio
- Subjects
régimenes climáticos del suelo ,monitoraje del suelo ,cambio climático ,Contenido de agua en el suelo ,temperatura del suelo - Abstract
El Institut Cartogràfic i Geològic de Catalunya (ICGC) actualmente tiene una red formada por 14 estaciones automáticas que miden los parámetros físicos de contenido de agua y temperatura del suelo. Estas estaciones están situadas en campos de cultivo de viña que han emigrado hacia cotas más altas para buscar condiciones climáticas más húmedas y frías (adaptación al cambio climático). Las estaciones están formadas por varios sensores ambientales (pluviometría, radiación solar, temperatura i humedad del aire) y por sensores enterrados en el suelo que miden el contenido de agua y la temperatura, situados a 5, 20, 50 y 100 cm de profundidad, y así poder contrastar los parámetros ambientales con los físicos del suelo. Son estaciones autónomas alimentadas por energía solar que, a través de un módem, transfieren los datos periódicamente a una base de datos remota situada en la sede central del ICGC. Estos datos son acesibles a través de un visor público en el cual se pueden consultar también la información edafólogica donde están situados los sensores. Los datos obtenidos de los sensores se pueden descargar en formato csv o visualizar graficamente. Estos datos se pueden visualizar gráficamente y descargar a través de un visor web de acceso público, el cual también permite consultar la información edafólogica del lugar donde está situada la estación. Los datos, además de permitir determinar los régimenes climáticos de los suelos, a medio plazo también serán útiles realizar estudios hidrológicos y de cambio climático; aunque para esto último se necesitan registro de los datos de intervalos de tiempo mayores, por lo que todavía quedará esperar ya que las primeras estaciones automáticas se instalaron en el 2017., Revista de Ciências Agrárias, Vol. 45 N.º 4 (2022)
- Published
- 2023
- Full Text
- View/download PDF
8. Red de estaciones de medida de parámetros físicos del suelo
- Author
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Boquera, Lola, Lladós, Agnès, and Jara, José Antonio
- Abstract
The Institut Cartogràfic i Geològic de Catalunya (ICGC) currently has a network of 14 automatic stations that measure the soil water content and temperature. These stations are installed in vineyards that have migrated to higher levels to search for more humid and colder climatic conditions (adaptation to climate change). Stations consist of various environmental sensors (rainfall, solar radiation, air temperature and humidity) and a set of sensors, buried into the ground at 5, 20, 50 and 100 cm depths, to measure water content and temperature, enabling to compare the environmental parameters with the physical ones of the soil. They are autonomous stations powered by solar energy that, through a modem, periodically transfer data to a remote database located at the ICGC headquarters. These data are displayed graphically and downloaded through an open web app, which also provides information about the soil where the station is located. Obtained data, in addition to compute the climatic regimes of soils, in the medium term will be useful to carry out hydrological and climate change studies; although for the latter, at least longer years of registration are needed, so it will still have to wait since because the first automatic stations were installed in 2017., El Institut Cartogràfic i Geològic de Catalunya (ICGC) actualmente tiene una red formada por 14 estaciones automáticas que miden los parámetros físicos de contenido de agua y temperatura del suelo. Estas estaciones están situadas en campos de cultivo de viña que han emigrado hacia cotas más altas para buscar condiciones climáticas más húmedas y frías (adaptación al cambio climático). Las estaciones están formadas por varios sensores ambientales (pluviometría, radiación solar, temperatura i humedad del aire) y por sensores enterrados en el suelo que miden el contenido de agua y la temperatura, situados a 5, 20, 50 y 100 cm de profundidad, y así poder contrastar los parámetros ambientales con los físicos del suelo. Son estaciones autónomas alimentadas por energía solar que, a través de un módem, transfieren los datos periódicamente a una base de datos remota situada en la sede central del ICGC. Estos datos son acesibles a través de un visor público en el cual se pueden consultar también la información edafólogica donde están situados los sensores. Los datos obtenidos de los sensores se pueden descargar en formato csv o visualizar graficamente. Estos datos se pueden visualizar gráficamente y descargar a través de un visor web de acceso público, el cual también permite consultar la información edafólogica del lugar donde está situada la estación. Los datos, además de permitir determinar los régimenes climáticos de los suelos, a medio plazo también serán útiles realizar estudios hidrológicos y de cambio climático; aunque para esto último se necesitan registro de los datos de intervalos de tiempo mayores, por lo que todavía quedará esperar ya que las primeras estaciones automáticas se instalaron en el 2017.
- Published
- 2023
9. Seismic monitoring of urban activity in Barcelona during the COVID-19 lockdown
- Author
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Ministerio de Ciencia, Innovación y Universidades (España), Generalitat de Catalunya, Ruiz Fernández, Mario [0000-0002-0924-8980], Diaz, J. [0000-0003-1801-0541], Diaz, J., Ruiz Fernández, Mario, Jara, José Antonio, Ministerio de Ciencia, Innovación y Universidades (España), Generalitat de Catalunya, Ruiz Fernández, Mario [0000-0002-0924-8980], Diaz, J. [0000-0003-1801-0541], Diaz, J., Ruiz Fernández, Mario, and Jara, José Antonio
- Abstract
During the COVID-19 pandemic lockdown, the city of Barcelona was covered by a dense seismic network consisting of up to 19 seismic sensors. This network has provided an excellent tool to investigate in detail the background seismic-noise variations associated with the lockdown measures. Permanent stations facilitate comparing the seismic noise recorded during the lockdown quieting with long-term variations due to holiday periods. On the other hand, the data acquired by the dense network show the differences between sites located near industrial areas, transportation hubs or residential areas. The results confirm that the quieting of human activity during lockdown has resulted in a reduction in seismic vibrations in the 2–20 Hz band that is clearly higher than during holiday seasons. This effect is observed throughout the city, but only those stations not affected by very proximal sources of vibration (construction sites, industries) are clearly correlated with the level of activity denoted by other indicators. Our contribution demonstrates that seismic amplitude variations can be used as a proxy for human activity in urban environments, providing details similar to those offered by other mobility indicators.
- Published
- 2021
10. Seismic monitoring of urban activity in Barcelona during the COVID-19 lockdown
- Author
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Diaz, Jordi, primary, Ruiz, Mario, additional, and Jara, José-Antonio, additional
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- 2021
- Full Text
- View/download PDF
11. Seismic monitoring of urban activity in Barcelona during COVID-19 lockdown
- Author
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Diaz, Jordi, primary, Ruiz, Mario, additional, and Jara, José-Antonio, additional
- Published
- 2020
- Full Text
- View/download PDF
12. Supplementary material to "Seismic monitoring of urban activity in Barcelona during COVID-19 lockdown"
- Author
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Diaz, Jordi, primary, Ruiz, Mario, additional, and Jara, José-Antonio, additional
- Published
- 2020
- Full Text
- View/download PDF
13. Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines
- Author
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Jara, José Antonio, primary, Rojas, Diego, additional, Castro-Castillo, Vicente, additional, Fuentes-Retamal, Sebastián, additional, Sandoval-Acuña, Cristian, additional, Parra, Eduardo, additional, Pavani, Mario, additional, Maya, Juan Diego, additional, Ferreira, Jorge, additional, and Catalán, Mabel, additional
- Published
- 2020
- Full Text
- View/download PDF
14. Activa Valverde, un caso de vinculación de la sociedad civil y la Universidad contra la despoblación
- Author
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Acosta-Naranjo, Rufino, primary, Domínguez Jara, José Antonio, primary, and Domínguez Ruiz, Victoria, primary
- Published
- 2019
- Full Text
- View/download PDF
15. Seismic monitoring of urban activity in Barcelona during COVID-19 lockdown.
- Author
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Diaz, Jordi, Ruiz, Mario, and Jara, José-Antonio
- Subjects
COVID-19 ,COVID-19 pandemic ,STAY-at-home orders ,SEISMIC networks ,MICROSEISMS ,BUILDING sites - Abstract
The city of Barcelona has been covered during the COVID-19 pandemic lockdown by a dense seismic network consisting of up to 19 seismic sensors. This network has provided an excellent tool to investigate in detail the background seismic noise variations associated to the lockdown measures. Permanent stations facilitate to compare the seismic noise recorded during the lockdown quieting with long-term variations due to holiday periods. On the other hand, the data acquired by the dense network show the differences between sites located near industrial areas, transportation hubs or residential areas. The results confirm that the quieting of human activity during lockdown has resulted in a reduction of seismic vibrations in the 2-20 Hz band clearly higher than during holiday seasons. This effect is observed throughout the city, but only those stations not affected by very proximal sources of vibration (construction sites, industries) are clearly correlated with the level of activity denoted by other indicators. Our contribution demonstrates that seismic amplitude variations can be used as a proxy for human activity in urban environments, providing details similar to those offered by other mobility indicators. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
16. Seismic Ambient Noise Characterization of a New Permanent Broadband Ocean Bottom Seismometer Site offshore Catalonia (Northeastern Iberian Peninsula)
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Frontera, Tànit, Ugalde, Arantza, Olivera, Carme, Jara, José Antonio, Goula, Xavier, Frontera, Tànit, Ugalde, Arantza, Olivera, Carme, Jara, José Antonio, and Goula, Xavier
- Abstract
The scientific importance of long-term ocean-floor seismic observatories has been widely and internationally recognized by earth science communities. In addition to their usefulness in investigating global-scale geophysical processes, long-term ocean-floor observations are also required to better constrain regional tectonics. However, the implementation of ocean-floor seismic stations is a difficult task, and efforts have been made for more than two decades to resolve the technological and logistical issues associated with such deployments (Romanowicz et al. 2009; Suyehiro et al. 2006). Different programs in the United States and Canada (e.g., NEPTUNE Project, http://www.neptune.washington.edu), Japan (e.g....
- Published
- 2010
17. Consultoría de negocio para la empresa Inmobiliaria Green House
- Author
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Barco Jara, José Antonio, Cotera Avellaneda, Carlos Fredy, Gallo Bartra, Margarita, Rosales García, José Antonio, Barco Jara, José Antonio, Cotera Avellaneda, Carlos Fredy, Gallo Bartra, Margarita, and Rosales García, José Antonio
- Abstract
Inmobiliaria Green House es una empresa especializada en el desarrollo de proyectos inmobiliarios, que inició operaciones en el año 2009 en la ciudad de Huancayo. Su principal línea de negocios es la construcción y comercialización de departamentos en edificios multifamiliares dirigidos al sector C y D, pero eventualmente participa también como proveedor de servicios de acabado y mantenimiento en proyectos e instalaciones de terceros, mayoritariamente en contrataciones con el Estado. En los últimos años, Green House experimentó un gran crecimiento en sus operaciones, alcanzado una facturación promedio de S/ 5.4 millones anuales en el periodo del 2016 al 2018 gracias al mayor tamaño de sus proyectos. Sin embargo, en este periodo de análisis, también enfrentó serias limitaciones para la generación de utilidades, obteniendo un margen neto promedio de 4.2% y llegando en el 2018 al valor mínimo en su historia de 0.8%. En el diagnóstico empresarial se determinó que el problema central de Green House es que no se está generando una rentabilidad que justifique la inversión, y el objetivo de esta consultoría fue identificar las principales causas que han dado origen a dicho problema, para proponer un plan de mejoras que permitan revertirlo. Posteriormente se concluyó que las causas de la baja rentabilidad de Green House que tuvieron mayor impacto en sus recientes resultados fueron: (a) la ausencia de gestión estratégica y generación de indicadores, (b) una inadecuada gestión de marketing, y (c) fallas en el aseguramiento de la calidad. Se propuso la implementación inmediata de siete iniciativas englobadas en tres soluciones: (a) diseño y mejora del plan estratégico, (b) implementación de plan de marketing y ventas; y (c) estandarización y mejora del proceso de aseguramiento de la calidad . El beneficio esperado de esta implementación en un escenario conservador sería de S/ 1,740,318 y ayudaría a Green House a alcanzar su nueva meta de rentabilidad, que, durante la etapa de c, Inmobiliaria Green House is a company specialized in the development of real estate projects, which began operations in 2009 in the city of Huancayo. Its main line of business is the construction and commercialization of departments in multi-family buildings aimed at sector C and D, but eventually it also participates as a provider of finishing and maintenance services in third-party projects and facilities, mostly in contracts with the State. In recent years, Green House experienced a great growth in its operations, reaching an average turnover of S/ 5.4 million soles per year in the period from 2016 to 2018 thanks to the larger size of its projects. However, in this period of analysis, it also faced serious limitations for the generation of profits, obtaining an average net margin of 4.2% and reaching the minimum value in its history of 0.8% in 2018. In the business diagnosis, it was determined that the central problem of Green House is that it is not generating a profitability that justifies the investment, and the objective of this consultancy was to identify the main causes that have given rise to this problem, in order to propose a plan of improvements that will allow it to be reversed. Then, it was concluded that the causes of the low profitability of Green House that have had the greatest impact on its recent results were (a) the absence of strategic management and generation of indicators, (b) a poor marketing management, and (c) failures in quality assurance. Seven initiatives were proposed for immediate implementation, grouped into three solutions: (a) design and improvement of the strategic plan; (b) implementation of the marketing and sales plan; and (c) standardization and improvement of the quality assurance process. The expected benefit of the implementation in a conservative scenario would be S/ 1,740,318 and would help Green House to reach its new profitability goal, which during the consulting phase, the company set at 10% net profit margin.
18. Consultoría de negocio para la empresa Inmobiliaria Green House
- Author
-
Barco Jara, José Antonio, Cotera Avellaneda, Carlos Fredy, Gallo Bartra, Margarita, Rosales García, José Antonio, Barco Jara, José Antonio, Cotera Avellaneda, Carlos Fredy, Gallo Bartra, Margarita, and Rosales García, José Antonio
- Abstract
Inmobiliaria Green House es una empresa especializada en el desarrollo de proyectos inmobiliarios, que inició operaciones en el año 2009 en la ciudad de Huancayo. Su principal línea de negocios es la construcción y comercialización de departamentos en edificios multifamiliares dirigidos al sector C y D, pero eventualmente participa también como proveedor de servicios de acabado y mantenimiento en proyectos e instalaciones de terceros, mayoritariamente en contrataciones con el Estado. En los últimos años, Green House experimentó un gran crecimiento en sus operaciones, alcanzado una facturación promedio de S/ 5.4 millones anuales en el periodo del 2016 al 2018 gracias al mayor tamaño de sus proyectos. Sin embargo, en este periodo de análisis, también enfrentó serias limitaciones para la generación de utilidades, obteniendo un margen neto promedio de 4.2% y llegando en el 2018 al valor mínimo en su historia de 0.8%. En el diagnóstico empresarial se determinó que el problema central de Green House es que no se está generando una rentabilidad que justifique la inversión, y el objetivo de esta consultoría fue identificar las principales causas que han dado origen a dicho problema, para proponer un plan de mejoras que permitan revertirlo. Posteriormente se concluyó que las causas de la baja rentabilidad de Green House que tuvieron mayor impacto en sus recientes resultados fueron: (a) la ausencia de gestión estratégica y generación de indicadores, (b) una inadecuada gestión de marketing, y (c) fallas en el aseguramiento de la calidad. Se propuso la implementación inmediata de siete iniciativas englobadas en tres soluciones: (a) diseño y mejora del plan estratégico, (b) implementación de plan de marketing y ventas; y (c) estandarización y mejora del proceso de aseguramiento de la calidad . El beneficio esperado de esta implementación en un escenario conservador sería de S/ 1,740,318 y ayudaría a Green House a alcanzar su nueva meta de rentabilidad, que, durante la etapa de c, Inmobiliaria Green House is a company specialized in the development of real estate projects, which began operations in 2009 in the city of Huancayo. Its main line of business is the construction and commercialization of departments in multi-family buildings aimed at sector C and D, but eventually it also participates as a provider of finishing and maintenance services in third-party projects and facilities, mostly in contracts with the State. In recent years, Green House experienced a great growth in its operations, reaching an average turnover of S/ 5.4 million soles per year in the period from 2016 to 2018 thanks to the larger size of its projects. However, in this period of analysis, it also faced serious limitations for the generation of profits, obtaining an average net margin of 4.2% and reaching the minimum value in its history of 0.8% in 2018. In the business diagnosis, it was determined that the central problem of Green House is that it is not generating a profitability that justifies the investment, and the objective of this consultancy was to identify the main causes that have given rise to this problem, in order to propose a plan of improvements that will allow it to be reversed. Then, it was concluded that the causes of the low profitability of Green House that have had the greatest impact on its recent results were (a) the absence of strategic management and generation of indicators, (b) a poor marketing management, and (c) failures in quality assurance. Seven initiatives were proposed for immediate implementation, grouped into three solutions: (a) design and improvement of the strategic plan; (b) implementation of the marketing and sales plan; and (c) standardization and improvement of the quality assurance process. The expected benefit of the implementation in a conservative scenario would be S/ 1,740,318 and would help Green House to reach its new profitability goal, which during the consulting phase, the company set at 10% net profit margin., Tesis
19. Consultoría de negocio para la empresa Inmobiliaria Green House
- Author
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Barco Jara, José Antonio, Cotera Avellaneda, Carlos Fredy, Gallo Bartra, Margarita, Rosales García, José Antonio, Barco Jara, José Antonio, Cotera Avellaneda, Carlos Fredy, Gallo Bartra, Margarita, and Rosales García, José Antonio
- Abstract
Inmobiliaria Green House es una empresa especializada en el desarrollo de proyectos inmobiliarios, que inició operaciones en el año 2009 en la ciudad de Huancayo. Su principal línea de negocios es la construcción y comercialización de departamentos en edificios multifamiliares dirigidos al sector C y D, pero eventualmente participa también como proveedor de servicios de acabado y mantenimiento en proyectos e instalaciones de terceros, mayoritariamente en contrataciones con el Estado. En los últimos años, Green House experimentó un gran crecimiento en sus operaciones, alcanzado una facturación promedio de S/ 5.4 millones anuales en el periodo del 2016 al 2018 gracias al mayor tamaño de sus proyectos. Sin embargo, en este periodo de análisis, también enfrentó serias limitaciones para la generación de utilidades, obteniendo un margen neto promedio de 4.2% y llegando en el 2018 al valor mínimo en su historia de 0.8%. En el diagnóstico empresarial se determinó que el problema central de Green House es que no se está generando una rentabilidad que justifique la inversión, y el objetivo de esta consultoría fue identificar las principales causas que han dado origen a dicho problema, para proponer un plan de mejoras que permitan revertirlo. Posteriormente se concluyó que las causas de la baja rentabilidad de Green House que tuvieron mayor impacto en sus recientes resultados fueron: (a) la ausencia de gestión estratégica y generación de indicadores, (b) una inadecuada gestión de marketing, y (c) fallas en el aseguramiento de la calidad. Se propuso la implementación inmediata de siete iniciativas englobadas en tres soluciones: (a) diseño y mejora del plan estratégico, (b) implementación de plan de marketing y ventas; y (c) estandarización y mejora del proceso de aseguramiento de la calidad . El beneficio esperado de esta implementación en un escenario conservador sería de S/ 1,740,318 y ayudaría a Green House a alcanzar su nueva meta de rentabilidad, que, durante la etapa de c, Inmobiliaria Green House is a company specialized in the development of real estate projects, which began operations in 2009 in the city of Huancayo. Its main line of business is the construction and commercialization of departments in multi-family buildings aimed at sector C and D, but eventually it also participates as a provider of finishing and maintenance services in third-party projects and facilities, mostly in contracts with the State. In recent years, Green House experienced a great growth in its operations, reaching an average turnover of S/ 5.4 million soles per year in the period from 2016 to 2018 thanks to the larger size of its projects. However, in this period of analysis, it also faced serious limitations for the generation of profits, obtaining an average net margin of 4.2% and reaching the minimum value in its history of 0.8% in 2018. In the business diagnosis, it was determined that the central problem of Green House is that it is not generating a profitability that justifies the investment, and the objective of this consultancy was to identify the main causes that have given rise to this problem, in order to propose a plan of improvements that will allow it to be reversed. Then, it was concluded that the causes of the low profitability of Green House that have had the greatest impact on its recent results were (a) the absence of strategic management and generation of indicators, (b) a poor marketing management, and (c) failures in quality assurance. Seven initiatives were proposed for immediate implementation, grouped into three solutions: (a) design and improvement of the strategic plan; (b) implementation of the marketing and sales plan; and (c) standardization and improvement of the quality assurance process. The expected benefit of the implementation in a conservative scenario would be S/ 1,740,318 and would help Green House to reach its new profitability goal, which during the consulting phase, the company set at 10% net profit margin.
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