1,009 results on '"Jansz P"'
Search Results
2. The Rapidly Evolving Landscape of DCD Heart Transplantation
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Joshi, Yashutosh, Wang, Katherine, MacLean, Campbell, Villanueva, Jeanette, Gao, Ling, Watson, Alasdair, Iyer, Arjun, Connellan, Mark, Granger, Emily, Jansz, Paul, and Macdonald, Peter
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- 2024
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Catalog
3. Who Benefits from the International Classroom? A Longitudinal Examination of Multicultural Personality Development during One Year of International Higher Education
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Joep Hofhuis, Joran Jongerling, and Jeroen Jansz
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Enhancing students' intercultural competences through international higher education requires a thorough understanding of the way in which these competences develop over time, how they relate to outcomes, and which factors predict their growth. To answer these questions, a three-wave longitudinal study was conducted among a sample of first-year students in an international university program (n = 425). Intercultural competences were operationalized through the five dimensions of the Multicultural Personality Questionnaire (MPQ): Cultural Empathy, Openmindedness, Flexibility, Social Initiative and Emotional Stability. We examined development of these traits across one year, as well as their relationship with stress, life satisfaction, and academic performance (GPA). Cultural background (local vs. international student) and prior international experience (yes/no) were included as predictors. Results show that MPQ scores at the beginning of the year negatively relate to change across semester 1, which in turn is negatively related to change across semester 2. These findings suggest the presence of ceiling effects in MPQ development. In semester 1, emotional stability acts as a buffer against stress. In semester 2, stress is lower among students with higher scores on cultural empathy, and lower scores on flexibility. Cultural empathy and social initiative relate positively to academic performance. No significant main effects were found for cultural background, or prior international experience. However, these predictors interact on openmindedness and social initiative: local students with no prior international experience show a significant increase in these dimensions across the first semester, whereas the others do not. more...
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- 2024
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4. LINE-1 retrotransposons contribute to mouse PV interneuron development
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Bodea, Gabriela O., Botto, Juan M., Ferreiro, Maria E., Sanchez-Luque, Francisco J., de los Rios Barreda, Jose, Rasmussen, Jay, Rahman, Muhammed A., Fenlon, Laura R., Jansz, Natasha, Gubert, Carolina, Gerdes, Patricia, Bodea, Liviu-Gabriel, Ajjikuttira, Prabha, Da Costa Guevara, Darwin J., Cumner, Linda, Bell, Charles C., Kozulin, Peter, Billon, Victor, Morell, Santiago, Kempen, Marie-Jeanne H. C., Love, Chloe J., Saha, Karabi, Palmer, Lucy M., Ewing, Adam D., Jhaveri, Dhanisha J., Richardson, Sandra R., Hannan, Anthony J., and Faulkner, Geoffrey J. more...
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- 2024
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5. High level of genomic divergence in orf-I p12 and hbz genes of HTLV-1 subtype-C in Central Australia
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Hirons, Ashley, Yurick, David, Jansz, Natasha, Ellenberg, Paula, Franchini, Genoveffa, Einsiedel, Lloyd, Khoury, Georges, and Purcell, Damian F. J.
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- 2024
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6. Who benefits from the international classroom? A longitudinal examination of multicultural personality development during one year of international higher education
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Hofhuis, Joep, Jongerling, Joran, and Jansz, Jeroen
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- 2024
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7. High level of genomic divergence in orf-I p12 and hbz genes of HTLV-1 subtype-C in Central Australia
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Ashley Hirons, David Yurick, Natasha Jansz, Paula Ellenberg, Genoveffa Franchini, Lloyd Einsiedel, Georges Khoury, and Damian F. J. Purcell
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Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Background Human T cell lymphotropic virus type 1 (HTLV-1) infection remains a largely neglected public health problem, particularly in resource-poor areas with high burden of communicable and non-communicable diseases, such as some remote populations in Central Australia where an estimated 37% of adults are infected with HTLV-1. Most of our understanding of HTLV-1 infection comes from studies of the globally spread subtype-A (HTLV-1a), with few molecular studies reported with the Austral-Melanesian subtype-C (HTLV-1c) predominant in the Indo-Pacific and Oceania regions. Results Using a primer walking strategy and direct sequencing, we constructed HTLV-1c genomic consensus sequences from 22 First Nations participants living with HTLV-1c in Central Australia. Phylogenetic and pairwise analysis of this subtype-C proviral gDNA showed higher levels of genomic divergence in comparison to previously published HTLV-1a genomes. While the overall genomic homology between subtypes was 92.5%, the lowest nucleotide and amino acid sequence identity occurred near the 3′ end of the proviral genome coding regulatory genes, especially overlapping hbz (85.37%, 77.46%, respectively) and orf-I product p12 (82.00%, 70.30%, respectively). Strikingly, the HTLV-1c genomic consensus sequences uniformly showed a defective translation start codon for the immune regulatory proteins p12/p8 encoded by the HTLV-1A orf-I. Deletions in the proviral genome were detected in many subjects, particularly in the structural gag, pol and env genes. Similarly, using a droplet digital PCR assay measuring the copies of gag and tax per reference host genome, we quantitatively confirmed that provirus retains the tax gene region at higher levels than gag. Conclusions Our genomic analysis of HTLV-1c in Central Australia in conjunction with earlier Melanesian HTLV-1c sequences, elucidate substantial differences with respect to the globally spread HTLV-1a. Future studies should address the impact these genomic differences have on infection and the regionally distinctive frequency of associated pulmonary disease. Understanding the host and virus subtype factors which contribute to the differential morbidity observed, is crucial for the development of much needed therapeutics and vaccine strategies against this highly endemic infection in remote First Nations communities in Central Australia. more...
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- 2024
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8. Using Machine Learning Approaches to Enhance Heatwave Measurement for Vulnerability Assessment and Timely Management of Heat-related Health Services
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Le Jian, Dimpal Patel, Jing Guo, Jianguo Xiao, Janis Jansz, Grace Yun, Ting Lin, Laura Kirkland, Tim Landrigan, and Andrew Robertson
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Machine learning ,climate change ,heatwave measurement ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Climate change is one of the most critical challenges facing Australia and the global community today. Data from the Australian Bureau of Meteorology (BoM) indicates that Australia has been experiencing rising temperatures, particularly since the late 20th century. The frequency, duration, and intensity of heatwaves are projected to continue increasing . Since national records began in 1910, Australia has warmed by an average of 1.47°C (±0.24°C), with the highest official temperature recorded at 50.7 degrees Celsius in Onslow, Western Australia (WA), on January 13, 2022. Furthermore, a recent unprecedented high temperature of +41.6°C was recorded during winter on August 26, 2024, in Yampi Sound, WA. Among all natural disasters in Australia, heatwave (HW) represents a leading silent killer and pose a significant public health threat. However, innovative methods for assessing vulnerability for HW-related health services remain limited. more...
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- 2024
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9. Corporate Manslaughter in the UK: Lessons for Australia
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Richard Phelps, Janis Jansz, Ping Chang, and Apurna Ghosh
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Corporate manslaughter ,Industrial manslaughter ,Prosecution ,Deterrence ,History of scholarship and learning. The humanities ,AZ20-999 ,Social sciences (General) ,H1-99 - Abstract
Prior to, and since the passage of the Corporate Manslaughter and Corporate Homicide Act 2008 (CMCHA) in the United Kingdom (UK), prosecutions for serious workplace health and safety offences have been mostly underwhelming. Australia has now followed the UK in legislating for industrial manslaughter within the various workplace health and safety laws across many of its states and territories. The aim of this paper is to explore the industrial manslaughter legislation across Australia and discusses the lessons which may be learned from the UK. An analysis of the CMCHA was undertaken to determine whether it has lived up to expectations and if there may be lessons to be learned for Australia as it embarks on its post-harmonization journey. A review of publications found that the CMCHA had fallen short of expectations within its first decade of existence in the UK in both the number of successful prosecutions and in the severity of the punishments handed down. The purported deficiencies in the prosecutorial success of the United Kingdom's CMCHA provides an opportunity for Australia to heed and avoid these deficiencies. more...
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- 2025
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10. Digital literacy games: a systematic literature review
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Teresa De La Hera, Laura Cañete Sanz, Nuria Navarro Sierra, Jeroen Jansz, Julia Kneer, René Glas, and Jasper van Vught
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digital literacy games ,media literacy competencies ,systematic literature review ,serious games ,serious games effects ,Communication. Mass media ,P87-96 - Abstract
This paper presents the results of a systematic literature review of academic publications about digital literacy games. We have analyzed a total of 30 papers and book chapters published in English, Spanish, Portuguese and Dutch between 2005 and 2021 and stored in Scopus. The results of this literature review report on: (1) the topics of the games discussed in the publications; (2) the digital literacy competencies supported by the games studied in the publications; (3) the effects of these games; and (4) ten game design considerations for digital literacy games collected from the results of the publications. This paper also provides detailed access to the original sources by reporting on which paper addressed what. more...
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- 2024
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11. Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial
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Lopes, Renato D, Higano, Celestia S, Slovin, Susan F, Nelson, Adam J, Bigelow, Robert, Sørensen, Per S, Melloni, Chiara, Goodman, Shaun G, Evans, Christopher P, Nilsson, Jan, Bhatt, Deepak L, Clarke, Noel W, Olesen, Tine K, Doyle-Olsen, Belinda T, Kristensen, Henriette, Arney, Lauren, Roe, Matthew T, Alexander, John H, Mol-Arts, Mirjam, Mansor-Lefebvre, Samreen, Zubovskiy, Konstantin, Blemings, Allan, Dugi, Klaus, Bloomfield, Gerald, Kontos, Chris, DeVore, Adam, Jordan, Dedrick, Kolls, Bradley, Matthews, Robin, Mehta, Rajendra, Povsic, Thomas J, Morse, Michael, Mahaffey, Kenneth W, Halabi, Susan, Leong, Darryl, Klotz, Laurence, Fleshner, Neil, Jansz, Godfrey, Giddens, Jonathan, Egerdie, Russell, Chin, Joseph, Zadra, Joseph, Casey, Richard, Simard, Jean, Niazi, Tamim, Martin, André-Guy, Babjuk, Marek, Hajek, Jaroslav, Klecka, Jiri, Kubes, Jiri, Schraml, Jan, Jakesova, Jitka, Vanasek, Jaroslav, Melichar, Bohuslav, Seikkula, Heikki, Abdiche, Manouar Samir, Colombel, Marc, Debourdeau, Philippe, Robert, Gregoire, Villers, Arnauld, Ploussard, Guillaume, Pradere, Benjamin, Bruyere, Franck, Descotes, Jean-Luc, Ouzaid, Idir, Winter, Alexander, Hanitzsch, Herbert, Sperling, Herbert, Eckert, Ralf, Hammerer, Peter, Stagge, Elke, Seseke, Florian, Szymula, Silvio, Bamias, Aristotelis, Thanos, Anastasios, Hatzimouratidis, Konstantinos, Mamoulakis, Charalambos, Kalofonos, Haralabos, Oszukowska, Elzbieta, Madziarska, Katarzyna, Fijuth, Jacek, Obarzanowski, Mateusz, Alekseev, Boris, Atduev, Vagif, Pushkar, Dmitri, Veliev, Evgeniy, Zyryanov, Alexander, Petrov, Sergey, Kopyltsov, Evgeny, Kozlov, Vadim, Macko, Ladislav, Dubravicky, Jozef, Polak, Richard, Mir, Obaidullah, Vargovcak, Marek, Mincik, Ivan, Kliment, Jan, Goncalves, Frederico, Mikulas, Juraj, and Sokol, Roman more...
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Cancer ,Clinical Trials and Supportive Activities ,Patient Safety ,Aging ,Prostate Cancer ,Urologic Diseases ,Cardiovascular ,Clinical Research ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Good Health and Well Being ,Aged ,Humans ,Leuprolide ,Male ,Oligopeptides ,Prospective Studies ,Prostatic Neoplasms ,agonists ,atherosclerosis ,cardiotoxicity ,drug therapy ,gonadotropin-releasing hormone ,prostatic neoplasms ,PRONOUNCE Study Investigators ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services ,Cardiovascular System & Hematology - Abstract
BackgroundThe relative cardiovascular safety of gonadotropin-releasing hormone (GnRH) antagonists compared with GnRH agonists in men with prostate cancer and known atherosclerotic cardiovascular disease remains controversial.MethodsIn this international, multicenter, prospective, randomized, open-label trial, men with prostate cancer and concomitant atherosclerotic cardiovascular disease were randomly assigned 1:1 to receive the GnRH antagonist degarelix or the GnRH agonist leuprolide for 12 months. The primary outcome was the time to first adjudicated major adverse cardiovascular event (composite of death, myocardial infarction, or stroke) through 12 months.ResultsBecause of slower-than-projected enrollment and fewer-than-projected primary outcome events, enrollment was stopped before the 900 planned participants were accrued. From May 3, 2016, to April 16, 2020, a total of 545 patients from 113 sites across 12 countries were randomly selected. Baseline characteristics were balanced between study groups. The median age was 73 years, 49.8% had localized prostate cancer; 26.3% had locally advanced disease, and 20.4% had metastatic disease. A major adverse cardiovascular event occurred in 15 (5.5%) patients assigned to degarelix and 11 (4.1%) patients assigned to leuprolide (hazard ratio, 1.28 [95% CI, 0.59-2.79]; P=0.53).ConclusionsPRONOUNCE (A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease) is the first, international, randomized clinical trial to prospectively compare the cardiovascular safety of a GnRH antagonist and a GnRH agonist in patients with prostate cancer. The study was terminated prematurely because of the smaller than planned number of participants and events, and no difference in major adverse cardiovascular events at 1 year between patients assigned to degarelix or leuprolide was observed. The relative cardiovascular safety of GnRH antagonists and agonists remains unresolved. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02663908. more...
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- 2021
12. SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease
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Andres Tapia del Fierro, Bianca den Hamer, Natalia Benetti, Natasha Jansz, Kelan Chen, Tamara Beck, Hannah Vanyai, Alexandra D. Gurzau, Lucia Daxinger, Shifeng Xue, Thanh Thao Nguyen Ly, Iromi Wanigasuriya, Megan Iminitoff, Kelsey Breslin, Harald Oey, Yvonne D. Krom, Dinja van der Hoorn, Linde F. Bouwman, Timothy M. Johanson, Matthew E. Ritchie, Quentin A. Gouil, Bruno Reversade, Fabrice Prin, Timothy Mohun, Silvère M. van der Maarel, Edwina McGlinn, James M. Murphy, Andrew Keniry, Jessica C. de Greef, and Marnie E. Blewitt more...
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Science - Abstract
Abstract The interplay between 3D chromatin architecture and gene silencing is incompletely understood. Here, we report a novel point mutation in the non-canonical SMC protein SMCHD1 that enhances its silencing capacity at endogenous developmental targets. Moreover, it also results in enhanced silencing at the facioscapulohumeral muscular dystrophy associated macrosatellite-array, D4Z4, resulting in enhanced repression of DUX4 encoded by this repeat. Heightened SMCHD1 silencing perturbs developmental Hox gene activation, causing a homeotic transformation in mice. Paradoxically, the mutant SMCHD1 appears to enhance insulation against other epigenetic regulators, including PRC2 and CTCF, while depleting long range chromatin interactions akin to what is observed in the absence of SMCHD1. These data suggest that SMCHD1’s role in long range chromatin interactions is not directly linked to gene silencing or insulating the chromatin, refining the model for how the different levels of SMCHD1-mediated chromatin regulation interact to bring about gene silencing in normal development and disease. more...
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- 2023
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13. Computational fluid dynamics simulate optimal design of segmental arteries reattachment: Influence of blood flow stagnationCentral MessagePerspective
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Yuki Ikeno, MD, PhD, Yoshishige Takayama, MEng, Michael L. Williams, MD, Yujiro Kawaniashi, MD, PhD, and Paul Jansz, MD, PhD
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basic science ,computational fluid dynamics ,spinal cord injury ,thoracoabdominal aortic aneurysm repair ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Surgery ,RD1-811 - Abstract
Objectives: This study aimed to simulate blood flow stagnation using computational fluid dynamics and to clarify the optimal design of segmental artery reattachment for thoracoabdominal aortic repair. Methods: Blood flow stagnation, defined by low-velocity volume or area of the segmental artery, was simulated by a 3-dimensional model emulating the systolic phase. Four groups were evaluated: direct anastomosis, graft interposition, loop-graft, and end graft. Based on contemporary clinical studies, direct anastomosis can provide a superior patency rate than other reattachment methods. We hypothesized that stagnation of the blood flow is negatively associated with patency rates. Over time, velocity changes were evaluated. Results: The direct anastomosis method led to the least blood flow stagnation, whilst the end-graft reattachment method resulted in worse blood flow stagnation. The loop-graft method was comparatively during late systole, which was also influenced by configuration of the side branch. Graft interposition using 20 mm showed a low-velocity area in the distal part of the side graft. When comparing length and diameter of an interposed graft, shorter and smaller branches resulted in less blood flow stagnation. Conclusions: In our simulation, direct anastomosis of the segmental artery resulted in the most efficient design in terms of blood flow stagnation. A shorter ( more...
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- 2023
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14. SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease
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Tapia del Fierro, Andres, den Hamer, Bianca, Benetti, Natalia, Jansz, Natasha, Chen, Kelan, Beck, Tamara, Vanyai, Hannah, Gurzau, Alexandra D., Daxinger, Lucia, Xue, Shifeng, Ly, Thanh Thao Nguyen, Wanigasuriya, Iromi, Iminitoff, Megan, Breslin, Kelsey, Oey, Harald, Krom, Yvonne D., van der Hoorn, Dinja, Bouwman, Linde F., Johanson, Timothy M., Ritchie, Matthew E., Gouil, Quentin A., Reversade, Bruno, Prin, Fabrice, Mohun, Timothy, van der Maarel, Silvère M., McGlinn, Edwina, Murphy, James M., Keniry, Andrew, de Greef, Jessica C., and Blewitt, Marnie E. more...
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- 2023
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15. Modified composite-graft technique for aortic root replacement
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Matsumoto, Yorihiko, Joshi, Yashutosh, Doyle, Mathew, Takahara, Shingo, Shimizu, Hideyuki, and Jansz, Paul
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- 2023
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16. Donation After Circulatory Death: A New Frontier
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Joshi, Yashutosh, Villanueva, Jeanette, Gao, Ling, Hwang, Bridget, Zhao, Christine, Doyle, Aoife, Wu, Jianxin, Jansz, Paul, and Macdonald, Peter
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- 2022
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17. Immune-mediated lung diseases: A narrative review
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Jaleel Jerry G. Sweis, Nabil W. G. Sweis, Fatima Alnaimat, Jacqueline Jansz, Ting-Wei Ernie Liao, Alaa Alsakaty, Abeera Azam, Hesham Elmergawy, Hali A. Hanson, Christian Ascoli, Israel Rubinstein, and Nadera Sweiss more...
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immune-mediated lung diseases ,interstitial lung disease ,connective tissue diseases ,post-COVID-19 ,idiopathic pulmonary fibrosis ,sarcoidosis ,Medicine (General) ,R5-920 - Abstract
The role of immunity in the pathogenesis of various pulmonary diseases, particularly interstitial lung diseases (ILDs), is being increasingly appreciated as mechanistic discoveries advance our knowledge in the field. Immune-mediated lung diseases demonstrate clinical and immunological heterogeneity and can be etiologically categorized into connective tissue disease (CTD)-associated, exposure-related, idiopathic, and other miscellaneous lung diseases including sarcoidosis, and post-lung transplant ILD. The immunopathogenesis of many of these diseases remains poorly defined and possibly involves either immune dysregulation, abnormal healing, chronic inflammation, or a combination of these, often in a background of genetic susceptibility. The heterogeneity and complex immunopathogenesis of ILDs complicate management, and thus a collaborative treatment team should work toward an individualized approach to address the unique needs of each patient. Current management of immune-mediated lung diseases is challenging; the choice of therapy is etiology-driven and includes corticosteroids, immunomodulatory drugs such as methotrexate, cyclophosphamide and mycophenolate mofetil, rituximab, or other measures such as discontinuation or avoidance of the inciting agent in exposure-related ILDs. Antifibrotic therapy is approved for some of the ILDs (e.g., idiopathic pulmonary fibrosis) and is being investigated for many others and has shown promising preliminary results. A dire need for advances in the management of immune-mediated lung disease persists in the absence of standardized management guidelines. more...
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- 2023
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18. Reducing Distance through Online International Collaboration
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Schreiber, Brooke R. and Jansz, Mihiri
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Online and hybrid courses offer many benefits for ESL teacher education, but can be hampered by 'transactional distance', a lack of interpersonal closeness which can cause misunderstanding and disengagement. This article describes a pedagogical project in which in-service teachers studying in a distance-learning MA TESL programme in Sri Lanka participated in an asynchronous discussion forum with peers from a university in New York City to discuss varieties of World Englishes. The project increased dialogue between learners, and between learners and the instructor, providing space for informal interactions through text, images, and video, as well as multiple methods for responding to feedback, ultimately reducing transactional distance. This article discusses the benefits of the project as well as the pedagogical and technological challenges, offering suggestions for other MA TESL educators about implementing such collaborations. more...
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- 2020
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19. BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation
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Andrew Keniry, Natasha Jansz, Linden J. Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M. Nefzger, Peter F. Hickey, Quentin Gouil, Joy Liu, Kelsey A. Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Andrew Jarratt, Sarah A. Kinkel, Phillippa C. Taberlay, Tracy Willson, Miha Pakusch, Matthew E. Ritchie, Douglas J. Hilton, Jose M. Polo, and Marnie E. Blewitt more...
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Science - Abstract
Female embryonic stem cells (ESCs) are the ideal model to study X chromosome inactivation (XCI) establishment; however, these cells are challenging to keep in culture. Here the authors create fluorescent ‘Xmas’ reporter mice as a renewable source of ESCs and show nucleosome remodelers Smarcc1 and Smarca4 create a nucleosome-free promoter region prior to the establishment of silencing. more...
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- 2022
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20. The sentinel skin free flap in solid organ transplantation: patient perspectives
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Matthew J Davies, Phaethon Karagiannis, Elias Moisidis, Paul Jansz, and Vlad Illie
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Surgery ,RD1-811 - Published
- 2023
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21. A systematic review of passing fit testing of the masks and respirators used during the COVID-19 pandemic: Part 1-quantitative fit test procedures.
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Anahita Fakherpour, Mehdi Jahangiri, and Janis Jansz
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Medicine ,Science - Abstract
BackgroundDuring respiratory infection pandemics, masks and respirators are highly sought after, especially for frontline healthcare workers and patients carrying respiratory viruses. The objective of this study was to systematically review fit test pass rates and identify factors influencing the fitting characteristics.MethodsPotentially relevant studies were identified using PubMed, Scopus, Web of Science, and Science Direct during the COVID-19 pandemic from February 5, 2020, to March 21, 2023. The search strategy using the following keywords was conducted: Quantitative Fit Test, Condensation Nuclei Counter, Controlled Negative Pressure, PortaCount, Sibata, Accufit, Fit, Seal, Mask, Respirator, Respiratory Protective Device, Respiratory Protective Equipment, Protective Device, Personal Protective Equipment, COVID-19, Coronavirus, and SARS-CoV-2. The quality of the included studies was also assessed using the Newcastle-Ottawa scale.ResultsA total of 137 articles met the eligibility criteria. Fifty articles had a quality score of less than 7 (good quality). A total of 21 studies had a fit test pass rate of less than 50%. 26 studies on disposable respirators and 11 studies on reusable respirators had an FF of less than 50 and less than 200, respectively. The most influential factors include respirator brand/model, style, gender, ethnicity, facial dimensions, facial hair, age, reuse, extensive movement, seal check, comfort and usability assessment, and training.Conclusion37.36% of the disposable respirator studies and 43% of the reusable respirator studies did not report fit test results. 67.86% of the disposable respirator studies had a fit test pass rate greater than 50%, and 35.84% of these studies had an FF greater than 100. Also, 85.71% of the reusable respirator studies had a fit test pass rate greater than 50%, and 52.77% of these studies had an FF greater than 1000. Overall, the fit test pass rate was relatively acceptable. Newly developed or modified respirators must undergo reliable testing to ensure the protection of HCWs. Subject and respirator characteristics should be considered when implementing fit testing protocols. An optimal fit test panel should be developed prior to respirator design, certification, procurement decisions, and selection procedures. more...
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- 2023
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22. COVID-19 and offshore oil and gas workers: The role of personality
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Emma D'Antoine, Janis Jansz, Ahmed Barifcani, Sherrilyn Shaw-Mills, Mark Harris, and Christopher Lagat
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Personality ,Big five personality model ,Psychosocial stress ,Offshore oil and gas ,History of scholarship and learning. The humanities ,AZ20-999 ,Social sciences (General) ,H1-99 - Abstract
This qualitative study aimed to identify mental health hazards in the offshore oil and gas industry, as well as the role of the personality types of the Five Factor Model (FFM) in coping with these stressors. A focus group with 8 participants and a pilot study with 5 participants were conducted. Results showed that several stressors are currently present for Australian offshore oil and gas employees, in particular COVID-19 and the resulting negative effects on rosters, working hours, job security and time spent away from home. Other stressors revealed by participants were lack of space, working in a high-risk environment, stigma, helicopter travel and pressure to keep up with production. Poor safety behaviours were associated with neuroticism, extraversion and openness, while risk avoidance appear to be associated with agreeableness and conscientiousness. Tolerance to shift work was positively related to extraversion, yet negatively associated to neuroticism. Furthermore, neuroticism showed a negative association with help-seeking and productivity, as well as higher levels of concern relating to COVID-19 and job uncertainty. As personality traits are enduring throughout life, it is vital that employees are managed effectively through workplace interventions so that they are able to cope effectively, particularly during stressful events. more...
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- 2023
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23. BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation
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Keniry, Andrew, Jansz, Natasha, Gearing, Linden J., Wanigasuriya, Iromi, Chen, Joseph, Nefzger, Christian M., Hickey, Peter F., Gouil, Quentin, Liu, Joy, Breslin, Kelsey A., Iminitoff, Megan, Beck, Tamara, Tapia del Fierro, Andres, Whitehead, Lachlan, Jarratt, Andrew, Kinkel, Sarah A., Taberlay, Phillippa C., Willson, Tracy, Pakusch, Miha, Ritchie, Matthew E., Hilton, Douglas J., Polo, Jose M., and Blewitt, Marnie E. more...
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- 2022
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24. Reduction in pacemaker rates post-heart transplantation with use of organ preservation systems
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Cherrett, C, primary, Adonopulos, A, additional, Phan, J, additional, Lee, W, additional, Walker, B, additional, Jansz, P, additional, Subbiah, R, additional, and Macdonald, P, additional
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- 2024
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25. Subaortic Pannus Causing Complete Outlet Obstruction After Bioprosthetic Aortic Valve Replacement in Left Ventricular Assist Device Patient
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Krishnaswamy, R.J., primary, Sivasubramaniam, V., additional, Robson, D., additional, Watson, A., additional, Jansz, P., additional, Hayward, C.S., additional, and Muthiah, K., additional
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- 2024
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26. Donation After Circulatory Death Heart Transplantation - Withdrawal Practices and Location Matter!
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Joshi, Y., primary, Fritis-Lamora, R., additional, Wang, K., additional, Villanueva, J., additional, Kim, S., additional, Kasavaraj, A., additional, Soto, C., additional, Iyer, A., additional, Watson, A., additional, Connellan, M., additional, Granger, E., additional, Jansz, P., additional, and MacDonald, P., additional more...
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- 2024
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27. Satisfactory Short and Long-Term Outcomes from Careful Selection of Older Donors for Lung Transplantation: An Australian Single-Centre Experience
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Dutta, S., primary, Iyer, A., additional, Watson, A., additional, Connellan, M., additional, Granger, E., additional, Plit, M., additional, Jansz, P., additional, and Darley, D., additional
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- 2024
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28. Initial Single Centre Experience with The XVIVO Hypothermic Perfusion System: Outcomes from the First 32 Cases
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Emmanuel, S., primary, MacDonald, P., additional, Hayward, C., additional, Muthiah, K., additional, Watson, A., additional, Iyer, A., additional, Connellan, M., additional, Granger, E., additional, Kaye, D., additional, McGiffin, D., additional, and Jansz, P., additional more...
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- 2024
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29. Utilizing All the Tools in the ‘Box’ for Heart Transplantation
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Joshi, Y., primary, Villanueva, J., additional, Emmanuel, S., additional, Cornelius, D., additional, Scheuer, S., additional, Soto, C., additional, Cropper, J., additional, Dinale, A., additional, Kaye, D., additional, McGiffin, D., additional, Iyer, A., additional, Watson, A., additional, Connellan, M., additional, Granger, E., additional, and Jansz, P., additional more...
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- 2024
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30. Vaccination in the Era of Immunosuppression
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Fatima Alnaimat, Jaleel Jerry G. Sweis, Jacqueline Jansz, Zeel Modi, Supritha Prasad, Ayman AbuHelal, Christen Vagts, Hali A. Hanson, Christian Ascoli, Richard M. Novak, Ilias C. Papanikolaou, Israel Rubinstein, and Nadera Sweiss more...
- Subjects
vaccination ,autoimmune ,immunosuppressed ,immune response ,Medicine - Abstract
Patients with autoimmune inflammatory rheumatic diseases (AIIRDs) are at increased risk for severe infections. Vaccine responses and safety profiles may differ between AIIRD patients and the general population. While patients with autoimmune inflammatory rheumatic diseases (AIIRDs) often experience diminished humoral responses and reduced vaccine efficacy, factors such as the type of immunosuppressant medications used and the specific vaccine employed contribute to these outcomes. Notably, individuals undergoing B cell depletion therapy tend to have poor vaccine immunogenicity. However, despite these considerations, vaccine responses are generally considered clinically sufficient. Ideally, immunosuppressed AIIRD patients should receive vaccinations at least two weeks before commencing immunosuppressive treatment. However, it is common for many patients to already be on immunosuppressants during the immunization process. Vaccination rarely triggers flares in AIIRDs; if flares occur, they are typically mild. Despite the heightened infection risk, including COVID-19, among AIIRD patients with rheumatoid arthritis, systemic lupus erythematosus, sarcoidosis, and other diseases on immunosuppressants, the vaccination rates remain suboptimal. The future directions of vaccination in the era of immunosuppression will likely involve customized vaccines with enhanced adjuvants and alternative delivery methods. By addressing the unique challenges faced by immunosuppressed individuals, we may improve vaccine efficacy, reduce the risk of infections, and ultimately enhance the health outcomes. Additionally, clinical trials to evaluate the safety and efficacy of temporarily discontinuing immunosuppressants during vaccination in various AIIRDs are crucial. more...
- Published
- 2023
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31. Psychosocial Safety and Health Hazards and Their Impacts on Offshore Oil and Gas Workers
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Emma D’Antoine, Janis Jansz, Ahmed Barifcani, Sherrilyn Shaw-Mills, Mark Harris, and Christopher Lagat
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psychosocial stressors ,offshore oil and gas ,workplace health and safety ,COVID-19 ,Industrial safety. Industrial accident prevention ,T55-55.3 ,Medicine (General) ,R5-920 - Abstract
The offshore oil and gas working environment is an inherently dangerous one, with risks posed to physical safety on a daily basis. One neglected field of research is the added psychosocial stressors present in this environment. This research examined the experiences of offshore oil and gas workers through one-on-one online interviews which were recorded and transcribed. Transcripts were analyzed through the qualitative software NVivo, which generated themes and patterns for the responses given to questions that were developed through a focus group. The results of the analysis showed that multiple psychosocial stressors are present in this population, such as fear of speaking up, unsatisfactory company-provided facilities, work–life interference, work status, micromanaging, gender harassment and bullying. In addition, interviews identified that production and time pressures, along with fatigue, can influence accidents and mistakes. Climate factors also cause discomfort. However, these are managed according to best practices by organizations. Due to the timing of the study, COVID-19 was a significant stressor for some, but not all, employees. In conclusion, offshore oil and gas workers face multiple stressors in a dangerous environment that may lead to devastating consequences. more...
- Published
- 2023
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32. Endogenous retroviruses in the origins and treatment of cancer
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Natasha Jansz and Geoffrey J. Faulkner
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Biology (General) ,QH301-705.5 ,Genetics ,QH426-470 - Abstract
Abstract Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer. As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate expression from gene networks, including those underpinning embryogenesis and immune cell function. ERV activation can promote an interferon response, a phenomenon termed viral mimicry. Although ERV expression is associated with cancer, and provisionally with autoimmune and neurodegenerative diseases, ERV-mediated inflammation is being explored as a way to sensitize tumors to immunotherapy. Here we review ERV co-option in development and innate immunity, the aberrant contribution of ERVs to tumorigenesis, and the wider biomedical potential of therapies directed at ERVs. more...
- Published
- 2021
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33. Using markers for digital engagement and social change: Tracking meaningful narrative exchange in transmedia edutainment with text analytics techniques
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Roel O Lutkenhaus, Hua Wang, Arvind Singhal, Jeroen Jansz, and Martine PA Bouman
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Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
While social media offer an unprecedented opportunity for orchestrating large-scale communication campaigns, it is often difficult to track audience responses on various digital platforms over time and to ascertain if their engagement is aligned with the original intention. In this article, we share a promising solution—the purposive embedding and tracking of unique content elements as “markers” using text analytics techniques. Four markers were introduced in an Indian melodramatic television serial, Main Kuch Bhi Kar Sakti Hoon ( I, A Woman, Can Achieve Anything ), which was part of a larger transmedia edutainment initiative in India to promote sanitation, family planning, and gender equality. These markers served as anchors for audience engagement with the originally intended messaging embedded in the narratives as well as for program monitoring and evaluation. We applied various web-based tools to systematically track marker-related engagement on Facebook, Twitter, and YouTube across eight months. We also conducted semantic network analysis to better understand how marker-related social media comments evolved over time. Our investigation of using markers for digital engagement and narrative exchange in MKBKSH makes an important and timely methodological contribution to the scholarship and praxis of social and behavior change communication. more...
- Published
- 2022
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34. In vivo tissue reaction within the outflow conduit in patients supported by HeartWare HVAD
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Jain, P., Robson, D., Shehab, S., Muthiah, K., Jansz, P., Qiu, M.R., Barrett, W., Sivasubramaniam, V., Kumaradevan, N., Macdonald, P.S., and Hayward, C.S.
- Published
- 2020
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35. Risk Factors for the Number of Sustained Injuries in Artisanal and Small-Scale Mining Operation
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Michael M. Ajith, Apurna K. Ghosh, and Janis Jansz
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Public aspects of medicine ,RA1-1270 - Abstract
Background: The relationship between risk factors and likelihood of occupational injury has been studied. However, what has been published has only provided a limited explanation of why some of the employees working in the same environment as other employees suffered a single-injury event, while other employees experienced multiple-injury events. This article reports on an investigation of whether artisanal and small-scale miners in Migori County of Kenya are susceptible to a single-injury or multiple-injury incidences, and if so, what underpinning parameters explain the differences between the single incident injured and the multiple incident injured group. Mine management commitment to safety in artisanal and small-scale mining (ASM) operations is also considered. Materials and methods: The research objectives were achieved by surveying 162 uninjured and 74 injured miners. A structured, closed-end questionnaire was administered to participants after the stratification of the study population and systematic selection of the representative samples. Results: The results showed that most injured miners suffer a single-injury incident rather than experiencing multiple-injury events, and laceration (28.40%) was the common injury suffered by the miners. The analysis showed that the risk factors for the single incident injured group were not similar to those in the multiple incident injured group. The research also found mine workers have low opinion about mine management/owners commitment to safety. Conclusion: The study concluded that mine management and miners need to be educated and sensitized on the dangers of this operation. Provision of safety gears and positive safety culture must be a top priority for management. Keywords: Incidence, Logistic model, Miners, Occupational injuries, Risk factors more...
- Published
- 2020
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36. Understanding income-related differences in distribution of child growth, behaviour and development using a cross-sectional sample of a clinical cohort study
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Michael Peer, Tara Kiran, Mary Beth Derocher, Margarita Lam-Antoniades, Peter Szatmari, Gerald Lebovic, Vincent Hildebrand, Arjumand Siddiqi, Peter Jüni, Christopher Allen, Julia Thompson, Charlie Guiang, Kevin Thorpe, Marty Perlmutar, Douglas Campbell, Andreas Laupacis, Curtis Handford, Suzanne Turner, Christine Koroshegyi, Jonathon L Maguire, Eric Duku, Caroline Reid-Westoby, Magdalena Janus, Catherine S. Birken, Jonathon L. Maguire, Ronald Cohn, Eddy Lau, Patricia C. Parkin, Michael Salter, Laura N. Anderson, Cornelia M. Borkhoff, Charles Keown-Stoneman, Christine Kowal, Dalah Mason, Murtala Abdurrahman, Kelly Anderson, Gordon Arbess, Jillian Baker, Tony Barozzino, Sylvie Bergeron, Dimple Bhagat, Gary Bloch, Joey Bonifacio, Ashna Bowry, Caroline Calpin, Sohail Cheema, Elaine Cheng, Brian Chisamore, Evelyn Constantin, Karoon Danayan, Paul Das, Anh Do, Kathleen Doukas, Anne Egger, Allison Farber, Amy Freedman, Sloane Freeman, Sharon Gazeley, Dan Ha, Laura Hanson, Lukasz Jagiello, Gwen Jansz, Paul Kadar, Florence Kim, Holly Knowles, Bruce Kwok, Sheila Lakhoo, Denis Leduc, Fok-Han Leung, Alan Li, Patricia Li, Jessica Malach, Roy Male, Vashti Mascoll, Aleks Meret, Maya Nader, Katherine Nash, Sharon Naymark, James Owen, Kifi Pena, Navindra Persaud, Andrew Pinto, Michelle Porepa, Vikky Qi, Danyaal Raza, Alana Rosenthal, Katherine Rouleau, Caroline Ruderman, Michael Sgro, Hafiz Shuja, Susan Shepherd, Barbara Smiltnieks, Stephen Treherne, Fatima Uddin, Meta van den Heuvel, Joanne Vaughan, Thea Weisdorf, Sheila Wijayasinghe, Peter Wong, John Yaremko, Ethel Ying, Elizabeth Young, Michael Zajdman, Farnaz Bazeghi, Vincent Bouchard, Marivic Bustos, Charmaine Camacho, Dharma Dalwadi, Tarandeep Malhi, Sharon Thadani, Laurie Thompson, Mary Aglipay, Imaan Bayoumi, Sarah Carsley, Katherine Cost, Karen Eny, Laura Kinlin, Jessica Omand, Shelley Vanderhout, Leigh Vanderloo, Bryan Boodhoo, Olivia Chan, David W.H. Dai, Judith Hall, Rita Kandel, Michelle Rodrigues, Hilde Vandenberghe, Patricia Raso, Amanda Offord, Faraz V Shahidi, Anne Fuller, Laura N Anderson, Catherine Birken, Charles D G Keown-Stoneman, Gurpreet Lakhanpal, Shannon Weir-Seeley, Sheila Jacobson LeahHarrington, Rosemary Moodie EliseMok, Noor Ramji NasreenRamji, Vanna Schiralli JanetSaunderson, Carolyn Taylor CinnthaSrikanthan, Pamela Ruth Flores, Mateenah Jaleel, Ataat Malick, Michelle Mitchell, Martin Ogwuru, Frank Ong, Rejina Rajendran, and Audra Stitt KarenPope more...
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Medicine - Published
- 2022
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37. Can we use a machine learning approach to predict the impact of heatwaves on emergency department attendance?
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Le Jian, Dimpalben Patel, Jianguo Xiao, Janis Jansz, Grace Yun, Ting Lin, and Andrew Robertson
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machine learning ,random forest ,geographical variation ,heatwaves ,air quality ,emergency department attendance ,Environmental sciences ,GE1-350 ,Meteorology. Climatology ,QC851-999 - Abstract
Global warming has contributed to more frequent and severe extreme weather events, which has led to increased research on the health impacts of extreme heat. However, research on heatwaves, air quality, and their spatial impact on health service demand is limited. This study used machine learning (ML) approaches to obtain the optimised model to predict health service demand associated with those risk factors for an all-age model and compared it with young children (0–4 years) model in Perth. Ten years’ data (2006–2015) on emergency department attendances (EDA), socioeconomic status (SES), heatwaves, landscape fires, and gaseous and particulate air pollutants were collected. ML approaches, including decision tree, random forest (RF), and geographical random forest (GRF) models, were used to compare and select the best model for predicting EDA and identify important risk factors. Five-hundred cross validations were performed using the testing data, and a construct validation was performed by comparing actual and predicted EDA data. The results showed that the RF model outperformed other models, and SES, air quality, and heatwaves were among the important risk factors to predict EDA. The GRF model was fitted well to the data (R ^2 = 0.975) and further showed that heatwaves had significant geographic variations and a joint effect with PM _2.5 in the southern suburbs of the study area for young children. The RF and GRF models have satisfactory performance in predicting the impact of heatwaves, air quality, and SES on EDA. Heatwaves and air quality have great spatial heterogeneity. Spatial interactions between heatwaves, SES, and air quality measures were the most important predictive risk factors of EDA for young children in the Perth southern suburbs. Future studies are warranted to confirm the findings from this study on a wider scale. more...
- Published
- 2023
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38. Playing in School or at Home? An Exploration of the Effects of Context on Educational Game Experience
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De Grove, Frederik, Van Looy, Jan, Neys, Joyce, and Jansz, Jeroen
- Abstract
The goal of this study is to gain insight into the effects of context on educational game experience. Using a quasi-experimental setup, it compares the playing and learning experiences of adolescent players of the awareness-raising game PING in a domestic (N=135) and a school (N=121) context. Results indicate that both gaming (identification, enjoyment) and learning experiences are more intense in a home compared to a school context. However, all of the variance in gaming and part of that in learning experience are caused by longer playing times and better computer equipment. Moreover, the overall impact of context on perceived learning is significantly smaller than that of other experiential factors such as identification and enjoyment. Thus context should be considered as a significant yet relatively small determinant of learning experience. (Contains 1 table.) more...
- Published
- 2012
39. The prevalence and incidence of vertebral fractures in end-stage renal disease and the role of parathyroid hormone
- Author
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Jansz, T. T., Goto, N. A., van Ballegooijen, A. J., Willems, H. C., Verhaar, M. C., and van Jaarsveld, B. C.
- Published
- 2020
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40. 954 Clinical results from a phase I dose escalation study in treatment-naïve early stage prostate cancer patients with ORCA-010, a potency enhanced oncolytic replication competent adenovirus
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Richard Casey, Wenliang Dong, Tereza Brachtlova, Allan Abramovitch, Jonathan Giddens, Peter Incze, Kenneth Jansz, and Victor van Beusechem
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2021
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41. An Evaluation of Interteaching in an Asynchronous Online Graduate-Level Behavior Analysis Course
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Rieken, Chrystal Jansz, Dotson, Wesley H., Carter, Stacy L., and Griffith, Annette K.
- Abstract
Interteaching (IT) has demonstrated more effective and durable learning than traditional lecture-style teaching. Whereas IT's effectiveness has been established in traditional face-to-face courses, there is a need to extend the evaluation of IT to increasingly common course delivery modalities such as online courses. The purpose of the present study was to compare IT and traditional online course delivery across two sections of the same graduate-level course. IT was adapted by having students form pairs to video chat synchronously about comprehension questions, submit a teaching record, and then listen to the instructor's recorded follow-up lecture to address the questions from the paired discussion. Results showed that students in the IT section performed better on average on quizzes and most assignments. more...
- Published
- 2018
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42. Endogenous retroviruses in the origins and treatment of cancer
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Jansz, Natasha and Faulkner, Geoffrey J.
- Published
- 2021
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43. Real-world effectiveness and tolerability of switching to doravirine-based antiretroviral therapy in people with HIV: a nationwide, matched, prospective cohort study
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Oomen, Patrick G A, Wit, Ferdinand W N M, Brinkman, Kees, Vrouenraets, Saskia M E, Mudrikova, Tania, van Welzen, Berend J, van der Valk, Marc, van Agtmael, M.A., Bomers, M., Geerlings, S.E., Goorhuis, A., Harris, V.C., Hovius, J.W., Lemkes, B., Nellen, F.J.B., Peters, E.J.G., van der Poll, T., Prins, J.M., Sigaloff, K.C.E., Spoorenberg, V., van Vugt, M., Wiersinga, W.J., Bruins, C., van Eden, J., Hylkema-van den Bout, I.J., Laan, L.M., Pijnappel, F.J.J., Smalhout, S.Y., Spelbrink, M.E., Weijsenfeld, A.M., Back, N.K.T., Cornelissen, M.T.E., van Houdt, R., Jonges, M., Jurriaans, S., Schinkel, C.J., Welkers, M.R.A., Wolthers, K.C., van den Berge, M., Stegeman, A., Baas, S., Hage de Looff, L., van Arkel, A., Stohr, J., Wintermans, B., Pronk, M.J.H., Ammerlaan, H.S.M., de Bree, C., de Munnik, E.S., Phaf, S., Deiman, B., Jansz, A.R., Scharnhorst, V., Tjhie, J., Wegdam, M.C.A., Nellen, J., van Eeden, A., Hoornenborg, E., de Stoppelaar, S., Alers, W., Elsenburg, L.J.M., Nobel, H., Schinkel, C.J., van Kasteren, M.E.E., Berrevoets, M.A.H., Brouwer, A.E., de Kruijf-van de Wiel, B.A.F.M., Adams, A., Pawels-van Rijkevoorsel, M., Murck, J.L., Rokx, C., Anas, A.A., Bax, H.I., van Gorp, E.C.M., de Mendonça Melo, M., van Nood, E., Nouwen, J.L., Rijnders, B.J.A., Schurink, C.A.M., Slobbe, L., de Vries-Sluijs, T.E.M.S., Bassant, N., van Beek, J.E.A., Vriesde, M., van Zonneveld, L.M., de Groot, J., van Kampen, J.J.A., Koopmans, M.P.G., Rahamat-Langendoen, J.C., Branger, J., Douma, R.A., Cents-Bosma, A.S., Mulder, M.A., Schippers, E.F., van Nieuwkoop, C., Geilings, J., van de Ven, E., van der Hut, G., van Burgel, N.D., Leyten, E.M.S., Gelinck, L.B.S., Mollema, F., Langbein, M., Wildenbeest, G.S., Nguyen, T., Groeneveld, P.H.P., Bouwhuis, J.W., Lammers, A.J.J., van Hulzen, A.G.W., Kraan, S., Kruiper, M.S.M., Debast, S.B., Wagenvoort, G.H.J., Roukens, A.H.E., de Boer, M.G.J., Jolink, H., Lambregts, M.M.C., Scheper, H., van Holten, N., van der Sluis, D., Claas, E.C.J., Wessels, E., den Hollander, J.G., El Moussaoui, R., Pogany, K., Brouwer, C.J., Heida-Peters, D., Mulder, E., Smit, J.V., Struik-Kalkman, D., van Niekerk, T., Pontesilli, O., van Tienen, C., Lowe, S.H., Oude Lashof, A.M.L., Posthouwer, D., Stoop, A., van Wolfswinkel, M.E., Ackens, R.P., Elasri, M., Houben-Pintaric, K., Schippers, J., Havenith, T.R.A., van Loo, M., van Vonderen, M.G.A., Kampschreur, L.M., Timmer, C., van Broekhuizen, M.C., Faber, S., Al Moujahid, A., Kootstra, G.J., Delsing, C.E., van der Burg-van de Plas, M., Scheiberlich, L., Kortmann, W., van Twillert, G., Renckens, R., Wagenaar, J., Ruiter-Pronk, D., Stander, B., Cohen Stuart, J.W.T., Hoogewerf, M., Rozemeijer, W., Sinnige, J.C., Brinkman, K., van den Berk, G.E.L., Lettinga, K.D., de Regt, M., Schouten, W.E.M., Stalenhoef, J.E., Blaauw, H., Geerders, G.F., Kleene, M.J., Knapen, M., Kok, M., van der Meché, I.B., Toonen, A.J.M., Wijnands, S., Wttewaal, E., Kwa, D., van de Laar, T.J.W., van Crevel, R., van Aerde, K., Dofferhoff, A.S.M., Henriet, S.S.V., ter Hofstede, H.J.M., Hoogerwerf, J., Richel, O., Albers, M., Grintjes-Huisman, K.J.T., de Haan, M., Marneef, M., McCall, M., Rahamat-Langendoen, J., Ruizendaal, E., Burger, D., Gisolf, E.H., Claassen, M., Hassing, R.J., ter Beest, G., van Bentum, P.H.M., Neijland, Y., Valette, M., Swanink, C.M.A., Klein Velderman, M., van Lelyveld, S.F.L., Soetekouw, R., van der Prijt, L.M.M., van der Swaluw, J., Kalpoe, J.S., Wagemakers, A., Vahidnia, A., Lauw, F.N., Verhagen, D.W.M., van Wijk, M., Bierman, W.F.W., Bakker, M., van Bentum, R.A., van den Boomgaard, M.A., Kleinnijenhuis, J., Kloeze, E., Middel, A., Postma, D.F., Schenk, H.M., Stienstra, Y., Wouthuyzen-Bakker, M., Boonstra, A., Maerman, M.M.M., de Weerd, D.A., van Eije, K.J., Knoester, M., van Leer-Buter, C.C., Niesters, H.G.M., Barth, R.E., Bruns, A.H.W., Ellerbroek, P.M., Hensgens, M.P.M., Oosterheert, J.J., Schadd, E.M., Verbon, A., Griffioen-van Santen, B.M.G., de Kroon, I., Schuurman, R., Verduyn Lunel, F.M., Wensing, A.M.J., van der Valk, M., Zaheri, S., Boyd, A.C., Bezemer, D.O., Jongen, V.W., van Sighem, A.I., Smit, C., Wit, F.W.M.N., Hillebregt, M.M.J., Woudstra, T.J., Rutkens, T., Bergsma, D., Brétin, N.M., Koster, L.E., Lelivelt, K.J., van de Sande, L., Schoorl, M.J.C., Visser, K.M., van der Vliet, S.T., Paling, F., van den Akker, M., Akpomukai, O.M., Alexander, R., Bakker, Y.M., Bastos Sales, L., El Berkaoui, A., Bezemer-Goedhart, M., Djoechro, E.A., Grolleman, J.M., El Hammoud, I., Khouw, M.R., Lodewijk, C.R.E., Lucas, E.G.A., van Meerveld-Derks, S., Mulder, H.W., Munjishvili, L., Ree, C.M.J., Regtop, R., van Rijk, A.F., Ruijs-Tiggelman, Y.M.C., Schnörr, P.P., van Veen, R., van Vliet-Klein Gunnewiek, W.H.G., and Witte, E.C.M. more...
- Abstract
Currently, real-world data on doravirine are scarce. In a national prospective cohort, we assessed the effectiveness and tolerability of switching to doravirine-based antiretroviral therapy (ART) in people with HIV. more...
- Published
- 2024
- Full Text
- View/download PDF
44. Outcomes After Transcatheter Mitral Valve Replacement According to Regurgitation Etiology.
- Author
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Perrin, Nils, Ben-Ali, Walid, Ludwig, Sebastian, Duncan, Alison, Weimann, Jessica, Nickenig, Georg, Tanaka, Tetsu, Coisne, Augustin, Vincentelli, Andre, Makkar, Raj, Webb, John G., Akodad, Mariama, Muller, David W.M., Jansz, Paul, Praz, Fabien, Reineke, David, Wild, Mirjam G., Hausleiter, Jörg, Goel, Sachin S., and Denti, Paolo more...
- Abstract
Whether transcatheter mitral valve replacement (TMVR) devices perform similarly with respect to the underlying mitral regurgitation (MR) etiology remains unknown. The aim of the present analysis was to assess outcomes of TMVR according to the MR underlying etiology among the CHoice of OptImal transCatheter trEatment for Mitral Insufficiency (CHOICE-MI) registry. Of 746 patients, 229 patients (30.7%) underwent TMVR. The study population was subdivided according to primary, secondary, or mixed MR. Patients with mitral annular calcification were excluded. The primary study endpoint was a composite endpoint of all-cause mortality or hospitalization for heart failure at 1 year. Secondary study endpoints were all-cause and cardiovascular mortality at 1 year, New York Heart Association functional class, and residual MR, both at discharge and 1 year. The predominant MR etiology was secondary MR (58.4%), followed by primary MR (28.7%) and mixed MR (12.9%). Technical success and procedural mortality were similar according to MR etiology. Discharge echocardiography revealed residual MR 2+ in 11.3%, 3.7%, and 5.3% of patients with primary, secondary, and mixed MR, respectively (P =.1). MR elimination was similar in all groups up to the 1-year follow-up. There was no difference in terms of primary combined outcome occurrence according to MR etiology. One-year all-cause mortality was reported in 28.8%, 24.2%, and 32.1% of patients with primary, secondary, and mixed MR, respectively (P =.07). In our study we did not find differences in short-term and 1-year outcomes after TMVR according to MR etiology. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
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45. With a Little Help from My Friends: Peer Coaching for Refugee Adolescents and the Role of Social Media
- Author
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Julia Kneer, Anne K. van Eldik, Jeroen Jansz, Susanne Eischeid, and Melek Usta
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adolescents ,peer coaching ,refugees ,social inclusion ,social media ,well-being ,Communication. Mass media ,P87-96 - Abstract
This intervention study investigated how much impact a specific peer-coaching (Peer2Peer) for refugee adolescents has on different factors of well-being for both sides: refugee adolescents (peers, N = 16) and their local peer coaches (buddies, N = 16). Next to pre- and post-tests, four buddies reflected on the process via weekly media diaries. We found that higher peer-loneliness and lower self-esteem was reported for peers in the beginning but these differences disappeared. These results were confirmed by buddies’ media diaries: language and communication barriers reduced and friendships between buddies and peers grew. Buddies also reported high feelings of responsibilities in their media diaries which led to worries about their peer, but also to pride due to peers’ improvement. Online communication was used on an almost daily basis to stay in contact each other. Snapchat was found to influence emotional and affectionate support. In sum, Peer2Peer as a program showed positive effects for both sides. Future Peer2Peer programs should include trainings on social media as well, as most apps are able to be used independent of own language skills. Thus, social media can help to overcome language barriers and intensifies the feeling of being supported. more...
- Published
- 2019
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46. Urban & Online: Social Media Use among Adolescents and Sense of Belonging to a Super-Diverse City
- Author
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Anne K. van Eldik, Julia Kneer, and Jeroen Jansz
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adolescents ,identity construction ,migration ,Rotterdam ,self-esteem ,social media ,super-diversity ,urban identity ,Communication. Mass media ,P87-96 - Abstract
In a world of continuous migration, super-diverse cities consist of a multitude of migrants and non-migrants from a variety of cultural backgrounds. Yet one characteristic they all have in common is the place where they currently live. In addition, both groups are active users of social media, especially the young. Social media provide platforms to construct and negotiate one’s identity—particularly the identity related to where one lives: urban identity. This article presents the results of a survey study (N = 324) investigating the relationships between social media engagement and identity construction among migrant and non-migrant adolescents in the super-diverse city of Rotterdam, the Netherlands. It was found that urban identity was significantly higher for migrants than non-migrants. Certain aspects of social media engagement predicted urban identity in combination with social identity. Finally, social media engagement was found to be positively related to group self-esteem. more...
- Published
- 2019
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47. Six-Month Outcomes After High-Risk Coronary Artery Bypass Graft Surgery and Preoperative Intra-aortic Balloon Counterpulsation Use: An Inception Cohort Study
- Author
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Bagshaw, Sean M., Keri-Anne Cowdrey, Heidi Buhr, Frengley, Rob, Ferrier, Janet, Gilder, Eileen, Henderson, Seton, Larobina, Marco, Merthens, Jan, Morgan, Matthew, Navarra, Lean, Rudas, Máté, Turner, Lisa, Reid, Kristen, Wise, Matthew, Young, Noel, Young, Paul, McGiffin, D, Duncan, J, Kaczmarek, M, Seevanayagam, S, Shaw, M, Shardey, G, Skillington, P, Chorley, T, Baker, L, Zhang, B, Bright, C, Baker, R, Canning, N, Gilfillan, I, Kruger, R, Fayers, T, Kyte, M, Doran, C, Smith, J, Baxter, H, Seah, P, Scaybrook, S, James, A, Goodwin, K, Dignan, R, Hewitt, N, Gerrard, K, Curtis, L, Tiruvoipati, R, Broukal, N, Wolfenden, H, Muir, V, Worthington, M, Wong, C, Tatoulis, J, Wynne, R, Marshman, D, Sze, D, Wilson, M, Turner, L, Passage, J, Kolybaba, M, Fermanis, G, Newbon, P, Newcomb, A, Mack, J, Duve, K, Jansz, P, Hunter, T, Bissaker, P, Dennis, N, Burke, N, Yadav, S, Cooper, K, Chard, R, Halaka, M, Tran, L, Huq, M, Billah, B, Reid, CM, Litton, Edward, Bass, Frances, Delaney, Anthony, Hillis, Graham, Marasco, Silvana, McGuinness, Shay, Myles, Paul S., Reid, Christopher M., and Smith, Julian A. more...
- Published
- 2018
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48. Improved right ventricular function following transapical transcatheter mitral valve implantation for severe mitral regurgitation
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Sara Hungerford, Nicole Bart, Paul Jansz, Sharon Kay, Sam Emmanuel, Mayooran Namasivayam, Gry Dahle, Alison Duncan, Christopher Hayward, and David W.M. Muller
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Echocardiography ,Mitral regurgitation ,Myocardial strain ,Right ventricular function ,Transcatheter mitral valve implantation ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Transapical transcatheter mitral valve implantation (TMVI) may be a therapeutic option for patients with severe mitral regurgitation (MR) excluded from cardiac surgery due to excessive risk. Exclusion criteria frequently include pulmonary hypertension and right ventricular (RV) dysfunction. The effect of TMVI on RV function has not previously been well-characterized. The aim of this study was to examine the procedural and 3-month impact of TMVI on RV hemodynamics and function. Methods: This was a multi-center, retrospective, observational cohort study of patients with >3+MR undergoing TMVI. Pre- and post-TMVI hemodynamics were assessed with right heart catheterization. RV function was assessed at baseline, pre-discharge and at 3-months by echocardiography. Results: Forty-six patients (age 72±9 years; 34 men) with ≥3+MR underwent TMVI over a 5-year period. Successful device implantation was achieved in all patients with abolition of MR (p < 0.001) and reduction in left-ventricular end-diastolic volume (p = 0.001). RV stroke work index (RVSWI) increased intra-operatively (7 ± 4 g/m/beat/m2 vs 11 ± 5 g/m/beat/m2; p < 0.001). At 3-months there were reductions in severity of tricuspid regurgitation (TR) (p < 0.001) and pulmonary artery systolic pressure (PASP) (49 ± 16 mmHg vs 36 ± 12 mmHg; p < 0.001), and improvements in RV fractional area change (28 ± 7% vs 34 ± 9%, p more...
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- 2021
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49. Psychotropic Medication Prescription for Autism: Data Sources for Decision Making
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Rieken, Chrystal Jansz, Griffith, Annette K., D’Angelo, Jacqueline Huscroft, and Re, Tyler
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- 2019
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50. Maternal ethnicity and iron status in early childhood in Toronto, Canada: a cross-sectional study
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Michael Peer, Tara Kiran, Noor Ramji, Mary Beth Derocher, Margarita Lam-Antoniades, Peter Szatmari, Gerald Lebovic, Peter Jüni, Colin Macarthur, Christopher Allen, Julia Thompson, Charlie Guiang, Kevin Thorpe, Marty Perlmutar, Douglas Campbell, Andreas Laupacis, Elise Mok, Curtis Handford, Suzanne Turner, Christine Koroshegyi, Catherine S. Birken, Jonathon L. Maguire, Ronald Cohn, Eddy Lau, Patricia C. Parkin, Michael Salter, Shannon Weir, Laura N. Anderson, Cornelia M. Borkhoff, Charles Keown-Stoneman, Christine Kowal, Dalah Mason, Murtala Abdurrahman, Kelly Anderson, Gordon Arbess, Jillian Baker, Tony Barozzino, Sylvie Bergeron, Dimple Bhagat, Gary Bloch, Joey Bonifacio, Ashna Bowry, Caroline Calpin, Sohail Cheema, Elaine Cheng, Brian Chisamore, Evelyn Constantin, Karoon Danayan, Paul Das, Anh Do, Kathleen Doukas, Anne Egger, Allison Farber, Amy Freedman, Sloane Freeman, Sharon Gazeley, Dan Ha, Laura Hanson, Leah Harrington, Sheila Jacobson, Lukasz Jagiello, Gwen Jansz, Paul Kadar, Florence Kim, Holly Knowles, Bruce Kwok, Sheila Lakhoo, Fok-Han Leung, Alan Li, Patricia Li, Jessica Malach, Roy Male, Vashti Mascoll, Aleks Meret, Rosemary Moodie, Maya Nader, Katherine Nash, Sharon Naymark, James Owen, Kifi Pena, Navindra Persaud, Andrew Pinto, Michelle Porepa, Vikky Qi, Nasreen Ramji, Danyaal Raza, Alana Rosenthal, Katherine Rouleau, Caroline Ruderman, Janet Saunderson, Vanna Schiralli, Michael Sgro, Hafiz Shuja, Susan Shepherd, Barbara Smiltnieks, Cinntha Srikanthan, Carolyn Taylor, Stephen Treherne, Fatima Uddin, Meta van den Heuvel, Joanne Vaughan, Thea Weisdorf, Sheila Wijayasinghe, Peter Wong, John Yaremko, Ethel Ying, Elizabeth Young, Michael Zajdman, Farnaz Bazeghi, Vincent Bouchard, Marivic Bustos, Charmaine Camacho, Dharma Dalwadi, Tarandeep Malhi, Sharon Thadani, Laurie Thompson, Mary Aglipay, Imaan Bayoumi, Sarah Carsley, Katherine Cost, Karen Eny, Theresa Kim, Laura Kinlin, Jessica Omand, Shelley Vanderhout, Leigh Vanderloo, Bryan Boodhoo, Olivia Chan, David W.H. Dai, Judith Hall, Karen Pope, Rita Kandel, Michelle Rodrigues, Hilde Vandenberghe, Gita Wahi, Vinusha Gunaseelan, and Denis Leuc more...
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Pediatrics ,RJ1-570 - Abstract
Objectives This study aimed to evaluate the association between maternal ethnicity and iron deficiency (ID) in early childhood, and to evaluate whether infant feeding practices linked to ID differ between maternal ethnic groups.Methods This was a cross-sectional study of healthy children 1–3 years of age. Adjusted multivariable logistic regression analyses were used to evaluate the association between maternal ethnicity and ID (serum ferritin 2 cups; meat consumption).Results Of 1851 children included, 12.2% had ID. Compared with the European referent group, we found higher odds of ID among children of South Asian and West Asian/North African maternal ethnicities, and lower odds of ID among children of East Asian maternal ethnicity. Statistically significant covariates associated with higher odds of ID included longer breastfeeding duration and daily cow’s milk intake >2 cups. Current infant formula use was associated with lower odds of ID. Children of South Asian maternal ethnicity had higher odds of bottle use beyond 15 months of age and lower odds of meat consumption.Conclusions We found increased odds of ID among children of South Asian and West Asian/Northern African maternal ethnicities. We found a higher odds of feeding practices linked to ID in children of South Asian maternal ethnicity, but not in children of West Asian/North African maternal ethnicity. Culturally tailored approaches to providing guidance to parents on healthy infant feeding practices may be important to prevent ID in early childhood.Trial registration number NCT01869530. more...
- Published
- 2020
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