624 results on '"Janssens L"'
Search Results
2. Phase 1 Studies of the Anti-Tau Monoclonal Antibody JNJ-63733657 in Healthy Participants and Participants with Alzheimer’s Disease
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Galpern, Wendy R., Triana-Baltzer, G., Li, L., Van Kolen, K., Timmers, M., Haeverans, K., Janssens, L., Kolb, H., Nandy, P., Aida, K., Shimizu, H., Mercken, M., and Sun, H.
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- 2024
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3. The atomic lensing model: new opportunities for atom-by-atom metrology of heterogeneous nanomaterials
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Bos, K. H. W. van den, Janssens, L., De Backer, A., Nellist, P. D., and Van Aert, S.
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
The atomic lensing model has been proposed as a promising method facilitating atom-counting in heterogeneous nanocrystals [KHW van den Bos et. al, Phys. Rev. Lett. 116 (2016) 246101] Here, image simulations will validate the model, which describes dynamical diffraction as a superposition of individual atoms focussing the incident electrons. It will be demonstrated that the model is reliable in the annular dark field regime for crystals having columns containing dozens of atoms. By using the principles of statistical detection theory, it will be shown that this model gives new opportunities for detecting compositional differences.
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- 2019
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4. The atomic lensing model: New opportunities for atom-by-atom metrology of heterogeneous nanomaterials
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van den Bos, K.H.W., Janssens, L., De Backer, A., Nellist, P.D., and Van Aert, S.
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- 2019
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5. Letter in response to: The use of guidelines to assess the risk of malignant hyperthermia in individuals with a RYR1 variant, by N. Voermans, C. Yang, M. Schouten, T. Girard, K. Stowell, S. Riazi et al.
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Herdewyn, S., primary, De Bleecker, J., additional, Janssens, L., additional, Symoens, S., additional, Milazzo, M., additional, and De Puydt, J., additional
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- 2023
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6. Bony labyrinth shape differs distinctively between modern wolves and dogs
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Janssens, L. A., Gunz, P., Stenger, T. E., Fischer, M. S., Boone, M., and Stoessel, A.
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- 2019
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7. Incidence of Post-ERCP Pancreatitis in Patients Receiving Diclofenac Versus Indomethacin Prophylaxis
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Janssens, L., additional, Yamparala, A., additional, Sathi, T., additional, Harmsen, W., additional, Lemke, E., additional, Dayyeh, B. Abu, additional, Bofill-Garcia, A., additional, Levy, M., additional, Martin, J., additional, Petersen, B., additional, Storm, A., additional, Topazian, M., additional, Valls, E. Vargas, additional, Chandrasekhara, V., additional, and Law, R., additional
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- 2023
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8. Continuous twin screw granulation of controlled release formulations with various HPMC grades
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Vanhoorne, V., Janssens, L., Vercruysse, J., De Beer, T., Remon, J.P., and Vervaet, C.
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- 2016
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9. Vormen de fysieke en psychosociale symptomen van long-Covid een syndroom? Een cross-sectioneel patiëntenonderzoek
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Domen, J., primary, Guler, I., additional, Swartenbroekx Janssens, L., additional, and Schoenmakers, B., additional
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- 2022
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10. Timing of inspiratory muscle activity in patients with unilateral diaphragm dysfunction
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Rodrigues, A, primary, Janssens, L, additional, Dacha, S, additional, Louvaris, Z, additional, Gojevic, T, additional, Janssens, W, additional, Brochard, L, additional, Gosselink, R, additional, Reid, W D, additional, and Langer, D, additional
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- 2022
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11. P-668 The LH endocrine profile in Gonadotropin-Releasing Hormone analogue cycles
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Janssens, L, primary, De Neubourg, D, additional, and Roelant, E, additional
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- 2022
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12. Impact of proton pump inhibitors on efficacy of antiplatelet strategies with ticagrelor or aspirin after percutaneous coronary intervention : insights from the GLOBAL LEADERS trial
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Ono, M., Onuma, Y., Kawashima, H., Hara, H., Gao, C., Wang, R., O'Leary, N., Benit, E., Janssens, L., Ferrario, M., Żurakowski, A., Dominici, M., Huber, K., Buszman, P., Garg, S., Wykrzykowska, J.J., Piek, J.J., Jüni, P., Hamm, C., Windecker, S., Vranckx, P., Deliargyris, E.N., Bhatt, D.L., Storey, R.F., Valgimigli, M., Serruys, P.W., and GLOBAL LEADERS trial investigators, (The)
- Abstract
Background\ud \ud Several studies have suggested that proton pump inhibitors (PPIs) may reduce the antiplatelet effects of clopidogrel and/or aspirin, possibly leading to cardiovascular events.\ud \ud \ud \ud Aims\ud \ud We aimed to investigate the association between PPI and clinical outcomes in patients treated with ticagrelor monotherapy or conventional antiplatelet therapy after percutaneous coronary intervention (PCI).\ud \ud \ud \ud Methods\ud \ud This is a subanalysis of the randomized GLOBAL LEADERS trial, comparing the experimental antiplatelet arm (23-month ticagrelor monotherapy following 1-month dual antiplatelet therapy [DAPT]) with the reference arm (12-month aspirin monotherapy following 12-month DAPT) after PCI. Patient-oriented composite endpoints (POCEs: all-cause mortality, myocardial infarction, stroke, or repeat revascularization) and its components were assessed stratified by PPI use as a time-dependent covariate in patients with the experiment or reference antiplatelet arm.\ud \ud \ud \ud Results\ud \ud Among 15,839 patients, 2115 patients (13.5%) experienced POCE at 2 years. In the reference arm, the use of PPIs was independently associated with POCE (hazard ratio [HR]: 1.27; 95% confidence interval [CI]: 1.12–1.44) and its individual components, whereas it was not in the experimental arm (HR: 1.04; 95% CI: 0.92–1.19; pinteraction = 0.035). During the second-year follow-up, patients taking aspirin with PPIs had a significantly higher risk of POCE compared to those on aspirin without PPIs (HR: 1.57; 95% CI: 1.27–1.94), whereas the risk did not differ significantly irrespective of PPI in ticagrelor monotherapy group (HR: 1.03; 95% CI: 0.83–1.28; pinteraction = 0.008).\ud \ud \ud \ud Conclusions\ud \ud In contrast to conventional antiplatelet strategy, there were no evidence suggesting the interaction between ticagrelor monotherapy and PPIs on increased cardiovascular events, which should be confirmed in further studies.\ud \ud \ud \ud Clinical Trial Registration\ud \ud URL: https://clinicaltrials.gov
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- 2022
13. Lipid-lowering therapy and risk-based LDL-C goal attainment in Belgium: DA VINCI observational study
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Van de Borne, P, Peeters, A, Janssens, L, Leone, A, Lemmens, R, Verhaegen, A, De Meulemeester, M, Balthazar, Y, Heijmans, S, Calozet, Y, Paquot, N, Carlier, S, Hemelsoet, D, Bray, S, Ray, KK, UCL - SSS/IONS - Institute of NeuroScience, and UCL - (SLuc) Service de neurologie
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Science & Technology ,Cardiac & Cardiovascular Systems ,hypertension ,diabetes ,CHOLESTEROL ,SOCIETY ,General Medicine ,Cardiovascular disease ,statins ,Cardiovascular System & Hematology ,CARDIOVASCULAR-DISEASE ,Cardiovascular System & Cardiology ,lipids (amino acids, peptides, and proteins) ,Human medicine ,Cardiology and Cardiovascular Medicine ,1102 Cardiorespiratory Medicine and Haematology ,Life Sciences & Biomedicine ,METAANALYSIS - Abstract
BACKGROUND: Cardiovascular disease (CVD) is one of the leading causes of death in Belgium. Current strategies for the prevention and management of CVD focus on reducing low-density lipoprotein cholesterol (LDL-C) levels. This analysis assessed whether LDL-C goals, recommended by the European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines, were being achieved in a Belgian study population. METHODS: The cross-sectional, observational, DA VINCI study enrolled patients prescribed lipid-lowering therapy (LLT) between 21 June 2017 and 20 November 2018. Data for patients from Belgium were extracted for this country-specific analysis. Primary endpoint was the proportion of patients who achieved 2016 ESC/EAS risk-based LDL-C goals; attainment of 2019 risk-based LDL-C goals was evaluated post hoc. RESULTS: Of 497 enrolled patients, 41% were female and mean age was 68 years. Among subjects with an LDL-C measurement on stabilised LLT, moderate-intensity statin monotherapy was the most prescribed LLT regimen (59%). Overall, 63% of patients achieved their risk-based LDL-C goals according to the 2016 ESC/EAS guidelines. Among patients with established ASCVD, risk-based LDL-C goal attainment was higher in patients with peripheral arterial disease (53%) than patients with coronary (37%) and cerebrovascular disease (42%). According to the updated 2019 ESC/EAS guidelines, less than half (41%) of patients achieved their risk-based LDL-C goal. The proportion of primary and secondary prevention patients who achieved 2019 risk-based LDL-C goals was 59% and 18%, respectively. CONCLUSION: These findings reveal a large gap between the LDL-C goals advocated by the ESC/EAS and the levels achieved in routine clinical practice in Belgium. ispartof: ACTA CARDIOLOGICA ispartof: location:England status: published
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- 2022
14. Grey wolf genomic history reveals a dual ancestry of dogs
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Bergström, A., Stanton, D. W. G., Taron, U. H., Frantz, L., Sinding, M. -H. S., Ersmark, E., Pfrengle, S., Cassatt-Johnstone, M., Lebrasseur, O., Girdland-Flink, L., Fernandes, D. M., Ollivier, M., Speidel, L., Gopalakrishnan, S., Westbury, M. V., Ramos-Madrigal, J., Feuerborn, T. R., Reiter, E., Gretzinger, J., Münzel, S. C., Swali, P., Conard, N. J., Carøe, C., Haile, J., Linderholm, A., Androsov, S., Barnes, I., Baumann, C., Benecke, N., Bocherens, H., Brace, S., Carden, R. F., Drucker, D. G., Fedorov, S., Gasparik, M., Germonpré, M., Grigoriev, S., Groves, P., Hertwig, S. T., Ivanova, V. V., Janssens, L., Jennings, R. P., Kasparov, A. K., Kirillova, I. V., Kurmaniyazov, I., Kuzmin, Y. V., Kosintsev, P. A., Lázničková-Galetová, M., Leduc, C., Nikolskiy, P., Nussbaumer, M., O’Drisceoil, C., Orlando, L., Outram, A., Pavlova, E. Y., Perri, A. R., Pilot, M., Pitulko, V. V., Plotnikov, V. V., Protopopov, A. V., Rehazek, A., Sablin, M., Seguin-Orlando, A., Storå, J., Verjux, C., Zaibert, V. F., Zazula, G., Crombé, P., Hansen, A. J., Willerslev, E., Leonard, J. A., Götherström, A., Pinhasi, R., Schuenemann, V. J., Hofreiter, M., Gilbert, M. T. P., Shapiro, B., Larson, G., Krause, J., Dalén, L., Skoglund, P., Bergström, A., Stanton, D. W. G., Taron, U. H., Frantz, L., Sinding, M. -H. S., Ersmark, E., Pfrengle, S., Cassatt-Johnstone, M., Lebrasseur, O., Girdland-Flink, L., Fernandes, D. M., Ollivier, M., Speidel, L., Gopalakrishnan, S., Westbury, M. V., Ramos-Madrigal, J., Feuerborn, T. R., Reiter, E., Gretzinger, J., Münzel, S. C., Swali, P., Conard, N. J., Carøe, C., Haile, J., Linderholm, A., Androsov, S., Barnes, I., Baumann, C., Benecke, N., Bocherens, H., Brace, S., Carden, R. F., Drucker, D. G., Fedorov, S., Gasparik, M., Germonpré, M., Grigoriev, S., Groves, P., Hertwig, S. T., Ivanova, V. V., Janssens, L., Jennings, R. P., Kasparov, A. K., Kirillova, I. V., Kurmaniyazov, I., Kuzmin, Y. V., Kosintsev, P. A., Lázničková-Galetová, M., Leduc, C., Nikolskiy, P., Nussbaumer, M., O’Drisceoil, C., Orlando, L., Outram, A., Pavlova, E. Y., Perri, A. R., Pilot, M., Pitulko, V. V., Plotnikov, V. V., Protopopov, A. V., Rehazek, A., Sablin, M., Seguin-Orlando, A., Storå, J., Verjux, C., Zaibert, V. F., Zazula, G., Crombé, P., Hansen, A. J., Willerslev, E., Leonard, J. A., Götherström, A., Pinhasi, R., Schuenemann, V. J., Hofreiter, M., Gilbert, M. T. P., Shapiro, B., Larson, G., Krause, J., Dalén, L., and Skoglund, P.
- Abstract
The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived1–8. Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000–30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located. © 2022, The Author(s).
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- 2022
15. Ticagrelor Monotherapy or Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation: Per-Protocol Analysis of the GLOBAL LEADERS Trial
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Gragnano, F., Zwahlen, M., Vranckx, P., Heg, D., Schmidlin, K., Hamm, C., Steg, P.G., Gargiulo, G., McFadden, E.P., Onuma, Y., Chichareon, P., Benit, E., Möllmann, H., Janssens, L., Leonardi, S., Zurakowski, A., Arrivi, A., Geuns, R.J.M. van, Huber, K., Slagboom, T., Calabrò, P., Serruys, P.W., Jüni, P., Valgimigli, M., Windecker, S., Gragnano, F., Zwahlen, M., Vranckx, P., Heg, D., Schmidlin, K., Hamm, C., Steg, P.G., Gargiulo, G., McFadden, E.P., Onuma, Y., Chichareon, P., Benit, E., Möllmann, H., Janssens, L., Leonardi, S., Zurakowski, A., Arrivi, A., Geuns, R.J.M. van, Huber, K., Slagboom, T., Calabrò, P., Serruys, P.W., Jüni, P., Valgimigli, M., and Windecker, S.
- Abstract
Contains fulltext : 252201.pdf (Publisher’s version ) (Open Access), Background In the GLOBAL LEADERS trial, ticagrelor monotherapy beyond 1 month compared with standard antiplatelet regimens after coronary stent implantation did not improve outcomes at intention-to-treat analysis. Considerable differences in treatment adherence between the experimental and control groups may have affected the intention-to-treat results. In this reanalysis of the GLOBAL LEADERS trial, we compared the experimental and control treatment strategies in a per-protocol analysis of patients who did not deviate from the study protocol. Methods and Results Baseline and postrandomization information were used to classify whether and when patients were deviating from the study protocol. With logistic regressions, we derived time-varying inverse probabilities of nondeviation from protocol to reconstruct the trial population without protocol deviation. The primary end point was a composite of all-cause mortality or nonfatal Q-wave myocardial infarction at 2 years. At 2-year follow-up, 1103 (13.8%) of 7980 patients in the experimental group and 785 (9.8%) of 7988 patients in the control group qualified as protocol deviators. At per-protocol analysis, the rate ratio for the primary end point was 0.88 (95% CI, 0.75-1.03; P=0.10) on the basis of 274 versus 325 events in the experimental versus control group. The rate ratio for the key safety end point of major bleeding was 1.00 (95% CI, 0.79-1.26; P=0.99). The per-protocol and intention-to-treat effect estimates were overall consistent. Conclusions Among patients who complied with the study protocol in the GLOBAL LEADERS trial, ticagrelor plus aspirin for 1 month followed by ticagrelor monotherapy was not superior to 1-year standard dual antiplatelet therapy followed by aspirin alone at 2 years after coronary stenting. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT01813435.
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- 2022
16. Risk of malignant hyperthermia in patients carrying a variant in the ryanodine receptor 1 gene
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Herdewyn, Sarah, Janssens, L, De Puydt, J, Symoens, Sofie, and De Bleecker, Jan
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Medicine and Health Sciences - Published
- 2022
17. Response to: The use of guidelines to assess the risk of malignant hyperthermia in individuals with a RYR1 variant
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Herdewyn, S., De Bleecker, J., Janssens, L., Symoens, S., Milazzo, M., and De Puydt, J.
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- 2024
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18. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial
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Bhatt, D, Steg, P, Mehta, S, Leiter, L, Simon, T, Fox, K, Held, C, Andersson, M, Himmelmann, A, Ridderstrale, W, Chen, J, Song, Y, Diaz, R, Goto, S, James, S, Ray, K, Parkhomenko, A, Kosiborod, M, Mcguire, D, Harrington, R, Santos, V, Jain, A, Lendel, I, Russo, M, Haught, W, Bouza, M, Gogia, H, Banerjee, S, Kichura, G, Kantaros, L, Padron, F, Passi, R, Stone, J, Pursley, M, D'Urso, M, Gardner, T, Bennett, J, Nour, K, Saini, S, Zhang, W, Kumbhani, D, Thomas, D, Angiolillo, D, Bertolet, B, Roman-Miranda, A, Black, R, Manshadi, R, Vaca, C, Blanco, A, Napoli, M, Brabham, D, Akyea-Djamson, A, Desai, P, Prasada, S, Khaira, A, Forgosh, L, Lieber, I, Umpierrez, G, Singal, D, Londono, J, Fraser, N, Ruiz, J, Vega, D, Rodriguez, L, Brown, C, Syed, F, Aggarwala, G, Eaves, W, Foster, M, Gupta, D, Avino, D, Asfour, W, Tonnessen, G, Zhao, X, Singh, N, Brockmyre, A, Lepor, N, Shammas, N, Blick, D, Hearne, S, Prodafikas, J, Carell, E, Izzo, M, Karim, A, Zakhary, B, Atieh, M, Leichter, S, Meadows, C, Hotchkiss, D, Abu-Fadel, M, Wiseman, A, Bander, J, Shah, M, Ganim, R, Sopko, K, Khan, M, Lloret, R, Weirick, T, Mehta, R, Thadani, U, Bhargava, A, Moya, J, Staniloae, C, Guerra, Y, Chhabra, A, Kosmicki, D, Shaheen, W, Mohammed, A, Bitters, J, Pattanayak, J, Javier, J, Srivastava, S, Phillips, R, Al-Amin, J, Lillestol, M, Simpson, P, Hazan, L, Amin, A, Shah, G, Korpas, D, Platt, B, Dickert, J, Puente, O, Hiotis, L, Doyle, T, Rajan, R, Meholick, A, Gring, C, Hage-Korban, E, Feldman, R, Colfer, H, Butman, S, Hart, T, Huling, R, Eshaghian, S, Quintana, O, Cheung, D, Handel, F, Rodriguez, M, Suh, D, Gordon, P, Pressman, G, Bauer, M, French, W, Barettella, M, Chatrathi, S, Suresh, D, Goldberg, R, Huth, M, Younis, L, Rahman, A, Mascolo, R, Welch, M, Suneja, R, Smith, S, Shurmur, S, Agaiby, J, Jingo, A, Johnston, J, Beth, M, Vlastaris, A, Kemp, S, Taheri, H, Pereira, E, Deyoung, M, Hawa, Z, Smith, R, Galski, T, Garas, S, Reddy, M, Sharma, S, Hargrove, J, Treasure, C, Emerson, R, Haddad, T, Rohr, K, Levinson, L, Gaona, R, Uretsky, B, Maheshwari, H, Lee, D, Kinnaman, S, Singal, R, Geohas, J, Gigliotti, O, Raisinghani, A, Khurana, C, Hella, B, Kelberman, M, Voyce, S, Singh, S, Lo, E, Singh, P, Goodfellow, R, Fischer, S, Lorraine, R, Turner, T, Shanes, J, Busch, R, Broker, R, Zaniewski, M, Pounds, K, Debs-Perez, G, Ong, S, Frandsen, B, Fullington, D, Jaffrani, N, Khan, A, Lee, M, Pouzar, J, Revtyak, G, Gonzalez, J, Nakhle, S, Murillo, A, Young, D, Makam, S, Syed, M, Woolf, K, Grena, P, Alfata, S, Mahal, S, Hoffman, D, Kizhakekuttu, T, Deering, J, Bhavsar, J, Mikesell, S, Wilson, W, Wilson, V, El, S, Spinale, F, Kannarkat, V, Rao, S, Hanson, L, Bertsch, J, Gonzalez-Ortiz, E, Severino, N, Willis, J, Schock, J, Bakhtari, L, Gazmuri, R, Ansari, S, Hall, J, Mehta, A, Shealy, N, Zarich, S, Singh, D, Vora, K, Andrawis, N, Molter, D, Maron, D, Cardona, J, D'Agostino, R, Arshad, T, Samaan, R, Jones, D, Presser, D, Heath, J, Green, S, Bittar, G, Henry, S, Korn, D, Schmedtje, J, Nadar, V, Graham, B, Labroo, A, Clavijo, L, Roseman, H, Ledesma, G, Rosen, R, Dor, I, Kirby, W, Sutton, J, Eder, F, Iteld, B, Gomez-Cortes, J, Buchbinder, M, Kasper, J, Terrelonge, A, Torres, G, Jagielo, T, Alvarez, J, Handelsman, Y, Guillen, M, Richwine, R, Lewy-Alterbaum, L, Corder, C, Arvind, M, Bolshoun, D, Mikhail, M, Minton, S, Alvarado, O, Abbott, J, Cauthen, B, Welter, R, Mintz, R, Cox, J, Quick, A, Weiss, M, Dy, J, Zebrack, J, Gandelman, G, Hegde, V, Silver, M, Degregorio, M, Lawson, W, Paa, C, Bortnick, A, Krolick, M, Sotolongo, R, Cheirif, J, Kumar, P, Jetty, P, Patel, A, Kruk, M, Kobielusz-Gembala, I, Rewerska, B, Madrzejewski, A, Milewski, K, Cygler, J, Petryka-Mazurkiewicz, J, Jastrzebski, W, Korecki, J, Fil, W, Prokopczuk, J, Bochenek, A, Wujkowski, M, Witek, R, Konczakowski, P, Miekus, P, Szczasny, M, Musial, W, Cymerman, K, Lampart, J, Mikosinski, J, Szynal, S, Fares, I, Opolski, G, Mazur, S, Wozakowska-Kaplon, B, Bijata-Bronisz, R, Wierucki, L, Losa, B, Drelich, G, Konieczny, M, Starczewski, P, Pawlowicz, L, Jesionowski, P, Jurowiecki, J, Gniot, J, Czyzycki, M, Stania, K, Kucharczyk-Bauman, I, Busz-Papiez, B, Karczmarczyk, A, Sudnik, W, Koszek, A, Kolodziej, P, Skwarna, B, Jaramillo, N, Jankowski, M, Czochra, W, Kinasz, L, Miklaszewicz, B, Stasinska, T, Pluta, W, Basiak, M, Rusicka, T, Niedbal-Yahfouf, I, Popenda, G, Korzeniak, R, Mirek, A, Mariankowski, R, Wojnowski, L, Korol, M, Baszak, J, Podolec, P, Piesiewicz, W, Zurakowski, A, Luengas, C, Skura, M, Pilecki, P, Majchrzak, P, Krzyzagorska, E, Drozd, M, Kaczmarek, B, Sliwinska, T, Zelazowska, K, Sztembis, R, Landa, K, Matyszczak-Toniak, L, Strojek, K, Piepiorka, M, Malinowski, R, Gorska, M, Stolarczyk-Sowa, E, Romanowski, L, Zinka, E, Reszka, Z, Skierkowska, J, Uzunow, A, Laskowska-Derlaga, E, Puntus, E, Kosmacheva, E, Koziolova, N, Pavlov, P, Supryadkina, T, Didenko, Y, Kopylov, P, Kazakov, A, Aksentiev, S, Vishneva, E, Repin, A, Smolenskaya, O, Mantserova, O, Khrustalev, O, Privalova, E, Konstantinov, V, Boldueva, S, Ezhov, A, Chernyavsky, A, Kamalov, G, Galyavich, A, Zubeeva, G, Nechaeva, G, Shustov, S, Dzhaiani, N, Treshkur, T, Osokina, N, Panov, A, Shutemova, E, Makukhin, V, Kropotina, T, Tsyba, L, Karpov, Y, Sizova, J, Ballyuzek, M, Tarasov, N, Demchenko, E, Barbarash, O, Moiseev, V, Markov, V, Kuznetsov, V, Viktorova, I, Sergienko, I, Ermoshkina, L, Khasanov, N, Khlevchuk, T, Baglikov, A, Shalaev, S, Zonova, E, Reznik, E, Haisheva, L, Morugova, T, Lomakin, N, Vishnevsky, A, Shvarts, Y, Magnitskaya, O, Mikhailusova, M, Pavlysh, E, Libov, I, Zateyschikova, A, Kostenko, V, Edin, A, Khovaeva, Y, Zakharov, K, Stryuk, R, Khirmanov, V, Kanorskiy, S, Yakushin, S, Barabashkina, A, Li, H, Zhao, Q, Zhang, J, Ma, J, He, Y, Luo, M, Zhang, A, Zhang, N, Chai, Y, Ma, G, Wang, H, Liu, Z, He, L, Song, Z, Dong, X, Tao, L, Li, Z, Su, X, Kong, X, Niu, H, Ge, J, Luo, Z, Huang, W, Peng, D, Yuan, Z, Milanova, M, Tenev, D, Gogov, A, Karageorgiev, D, Kolchev, T, Rusev, N, Georgieva, N, 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D., O'Keefe D., Sabbah E., Bell A., Chouinard G., Wong B., Miller M., Gaudet D., Lachance P., Bata I., Petrella R., Gossard D., Dumas R., Ing D., Boyrazian H., Bessoudo R., Huynh T. T., Hart R., Belle-Isle J., Shukla D., Kelly A., Mazza G., Cha J., Henein S., Frechette A., Vizel S., Liutkus J. F., O'Mahony M., Halperin F., Kooy J., Graham J., Bailey A., Wojcik R., Wilderman I., Turi T., Motyovszki A., Merkely B., Kiss R. G., Kiraly C., Andrassy P., Sarszegi Z., Fulop T., Zilahi Z., Edes I., Papp A., Muller G., Czigany A., Zolyomi S., Koranyi L., Takacs J., Juhasz F., Benczur B., Kancz S., Foldi A., Nagy A. C., Bakai J., Greschik I., Puski L., Nagy L., Kirschner R., Kuchar R., Hajek P., Busak L., Michalik D., Matyasek I., Marusincova I., Kucera D., Jerabek O., Honkova M., Dedek V., Rihacek I., Kos P., Slaby J., Machkova M., Zidkova E., Elbl L., Grunfeldova H., Carda J., Mrozek V., Maly J., Milkovic R., Malecha J., Skalicka H., Oral I., Krcova E., Lisa L., Belohlavek J., Miklik R., Cermak O., Bednarova J., Peroutka Z., Spinar J., Wilke A., Appel K. -F., Taggeselle J., Forster A., Toursarkissian N., Schmidt E., Bott J., Al-Zoebi A., Hennig D., Schon N., Sauter J., Simonis G., Nischik R., Rieker W., Schenkenberger I., Behnke T., Klausmann G., Jeserich M., Trenk D., Weigmann I., Reuter H., Rummel R., von Munchhausen C., von Engelhardt C., Horibe E., Shibasaki T., Sato T., Kakuta T., Michishita I., Tan M., Ishiki R., Aoyama T., Higashiue S., Niijima Y., Idogaki A., Hasegawa T., Kiyosue A., Tomobuchi Y., Kawamitsu K., Kawasaki S., Hata Y., Fukui K., Seki K., Takenaka T., Abe M., Utsu N., Oono A., Mitsuo K., Sueyoshi A., Hirohata A., Tsujimoto M., Ueda O., Takase S., Suzuki M., Sakuragi S., Yamamoto F., Fujimoto N., Kakinoki S., Sugiura T., Sugino H., Nakamura T., Kadokami T., Uehara H., Ono M., Yokoya K., Koike A., Komatsu S., Sonoda M., Ueno H., Doi T., Takagi Y., Fujimoto K., Eki Y., Okubo M., Sasaki K., van Eck M., Ronner E., The S., van de Wal R., Nierop P., de Nooijer C., Werner H., Westendorp I., van der Zwaan C., Crijns H., Cornel J. H., Strikwerda S., Bos R., de Melker E., Kuijper A., Louwerenburg H., Plomp J., Dantzig J. -M., Prins F., van Kesteren H., Willems F., Amoroso G., Carnero G., Duronto E., Besada D., Chacon C., Zangroniz P., Solis S., Liberman A., Sernia V., Alvarisqueta A., Maffei L., Vilamajo O. G., Garcia C., Sicer M., Muntaner J., Bordonava A., Albisu J., Zanini A., Rista L., Hominal M., Estrada J. N., Prado A., Gosparini D. M., Schiavi B., Castillo A. G., Ruiz J. G., Martinez G. R., Lopez V. G., Rosas E. L., Lopez G. R., Cantu E. G., de los Rios Ibarra M., Padilla F. P., Carrasco J. P., Carrillo L. V., Garcia J. D., Askar A. N., Salinas C. A., Gamba M. A., Sanchez C. G., Cantu A. G., Sanchez R. V., Madrigal J. C., Urbano R. H., Romo A. I., Gonzalez Juanatey J. R., Racugno P., Fillat A. C., de la Torre Hernandez J. M., Pelaez J. A., Cortada J. B., Pavia P. G., Navarro M. J., Asenjo R. M., Diaz F. F., Peligero E. B., Manterola F. A., Ortiz A. F., Mediavilla Garcia J. D., Ortuno F. M., Vera T. R., Gonzalez A. S., Vinas J. A., Fernandez Portales F. J., Mayordomo P. S., Ojeda F. B., Dominguez A. R., Gonzalez R. S., Guerrero D. B., Ruiz Nodar J. M., Marimon X. G., Margaez J. G., Aguilera R. M., Diaz Fernandez J. F., Zamorano Gomez J. L., Gonzalez V. B., del Blanco B. G., Perez I. P., Moreno M. R., Ereno A. R., Garcia Lledo J. A., Prieto J., Villablanca A., Raffo C., Pincetti C., Conejeros C., Roman O., Varleta P., Goldberg C., Sandoval J., Arriagada G., Corbalan R., Leon L., Potthoff S., Cobos J., Figueroa C., Makotoko E., Fourie N., Burgess L., Nortje H., Theron R., Pillai P., Ranjith N., Trokis J., Pillay S., Reddy J., Nunkoo T., Kapp C., Urbach D., Distiller L., Horak A., van Zyl L., Coetzee K., Punt Z., Bayat J., Dawood S., Mitha I., Padayachee T., Hoosen F., Dalby A., Gowdaiah P., Mehta V., Chag M., Gadkari M., Ramamurthee K., Das A., Sawhney J. S., Sathe P., Adhyapak S., Nguyen T., Pham V., Do H., Nguyen A., Nguyen H., Truong B., Jamil-Copley S., Lang C., Pell A., Zaman A., Storey R., Swanson N., Sharman D., Braganza D., Hammond P., Moriarty A., Bain S., Pye M., Sharp A., Blagden M., Randeva H., Myhill T., Viswanathan G., Keeling P., Clifford P., Saxena M., Lyons K., McMurray J., Jaafar F., Murphy C., Cartwright S., Abouglila K., Antalik L., Krajci P., Urban M., Fazekas F., Pella D., Koleny D., Vykoukalova T., Macek V., Vinanska D., Jamriskova L., Such S., Fulop P., Farsky S., Bugan V., Strbova J., Micko K., Palka Jr J., Sivak V., Kristensen D., Refsgaard J., Holmvang L., Dixen U., Nielsen H., Egstrup K., Jensen L. O., Sykulski R., Rasmussen O., Andries A., Luckow A., Nielsen G., Sorensen T., Wongvipaporn C., Chamnarnphol N., Srimahachota S., Sansanayudh N., Kuanprasert S., Tresukosol D., Sookananchai B., Kanadasi M., Ozcan T., Kucuk M., Ongen Z., Okuyan E., Arat A., Acikel S., Yalcin A., Guray U., Ceyhan C., Ozer N., Arslan S., Angeras O., Johnston N., Weiderman A. -C., Bandh S., Hansen O., Larnefeldt H., Kusiak D., Lindholm C. -J., Hedman A., Erlinge D., Curiac D., Lundman P., Zucconi-Mazzini R., Aladellie L., Jensen J., Verwerft J., Vrolix M., Faes D., Striekwold H., Sinnaeve P., Timmermans P., Guedes A., Delforge M., Nimmegeers J., Stammen F., Buysschaert I., Hoffer E., Hollanders G., Vervoort G., Coussement P., de Maeseneire S., Janssens L., Gravdal S. A., Risberg K., Gullestad L., Hofseth O. D., Nilsen D., Lappegard K. T., van den Heuvel C., Gibbs C., Khusrawi A., Arora S., Tomala T., Kjaernli T., Berg-Johansen J., Hagemeier R., Skjelvan G., Colquhoun D., Amerena J., Morbey C., Hammett C., Dart A., Lehman R., Hamilton A., Worthley M., Purnell P., Whelan A., MacIsaac R., Arya K., Linjawi S., Proietto J., Prasad L., Rodriguez A., Godoy A., Rodriguez V., Berrospi P., Chavez C., Negron S., Heredia J., Medina F., Manrique H., Cabrera W., Cordova F., Quinteros T., Haro J. M., Regalado S., Guitton J., Arbanil H., Pansieri M., Decoulx E., Goube P., de Labriolle A., Labeque J. N., Range G., Cottin Y., Montalescot G., Cayla G., Danchin N., Angoulvant D., Ferrario E., Elbaz M., Dubreuil O., Fontaine C., Sorbets E., Omer H., Al-Saif S., Al-Faleh H., Al-Shehri A., El-Amin O., Alshehri H., Bazari R., Hei P., Ying M., Chan M., Wong M., Ma R., Siu S. C., Tsang C. C., Ferrario M., Assanelli E., Senni M., Piatti P., Calabro P., Urbinati S., Michisanti M., Varbella F., de Cosmo S., Trevisan R., Bellotti S., Di Pasquale G., Bongo A. S., Uguccioni M., Mannucci E., Mauro C., Ragonese M., Fresco C., Turturo M., Marcucci R., Lievano Triana M. J., Arana C., Accini J., Botero R., Muzyk-Osikowicz M., Dada F. T., Vallejo G. S., Manzur F., Isaza D., Molina D., Mesa J. G., Quintero A., Nyman K., Makela J., Strand J., Nieminen S., Taurio J., Kuusela M., Valle T., Pietila M., Kekki S., Strandberg T., Klutstein M., Greenberg G., Rozenman Y., Chorin E., Roguin A., Lewis B., Bashkin A., Tan E., Prado J. P., Ferrolino A., Babilonia N., Barbas B., Matiga G., Coching R. M., Drexel H., Brath H., Schnack C., Hanusch U., Fliesser-Gorzer E., Paulweber B., Ebenbichler C., Prager R., Huber K., Wolzt M., Auer J., Berger R., Schernthaner G. -H., Stanciulescu G., Creteanu M., Spiridon M., Dobreanu V., Vinereanu D., Iosipescu L. C., Istratoaie O., Coman I., Militaru C., Cinteza M., Sinnaeve P. R., Nicolau J. C., Kerr Saraiva J. F., Widimsky P., Kristensen S. D., Hartikainen J., Darius H., Tse H. F., Pais P., Lev E., de Luca L., Ramos Lopez G. A., Kontny F., Babilonia N. A., Zateyshchikov D. A., Ruda M., Elamin O., Kovar F., Dalby A. J., Bueno H., Chiang C. -E., Parkhomenko A., Nguyen T. Q., and Leonsson-Zachrisson M.
- Abstract
Background: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. Methods: The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population). Findings: Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, pinteraction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo
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- 2019
19. The Incubation time of Relapses after Treatment of Multibacillary Leprosy with Rifampicin Containing Regimens
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Pattyn, S. R., Groenen, G., Bourland, J., De Muynck, A., Grillone, S., Grossetete, G., Husser, J. A., and Janssens, L.
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- 1988
20. The pace-of life explains whether gills improve or exacerbate pesticide sensitivity in a damselfly larva*
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Janssens, L., Verberk, W.C.E.P., Stoks, R., Janssens, L., Verberk, W.C.E.P., and Stoks, R.
- Abstract
Contains fulltext : 235696.pdf (Publisher’s version ) (Closed access)
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- 2021
21. Validation of the all-comers design: Results of the TARGET-AC substudy
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Toth, G.G., Lansky, A., Baumbach, A., Kelbæk, H., Royen, N. van, Holmvang, L., Janssens, L., Brugaletta, S., Barbato, E., Maillard, L., Kiemeneij, F., Naber, C.K., Pucher, F., Laursen, P.N., Ameloot, K., Robles, C., Milkas, A., Sevilla, J., Jensen, C., Wijns, W., Toth, G.G., Lansky, A., Baumbach, A., Kelbæk, H., Royen, N. van, Holmvang, L., Janssens, L., Brugaletta, S., Barbato, E., Maillard, L., Kiemeneij, F., Naber, C.K., Pucher, F., Laursen, P.N., Ameloot, K., Robles, C., Milkas, A., Sevilla, J., Jensen, C., and Wijns, W.
- Abstract
Item does not contain fulltext, BACKGROUND: Results of clinical trials are often criticized by low inclusion rate and potential sampling bias in patient recruitment. The aim of this validation registry is to evaluate how far an all-comers design in the context of clinical research can ensure the representation of the true all-comers population. METHODS: This validation registry is a prospective international multicentre registry, conducted at 10 out of the total 21 centers, participating in TARGET-AC (registered under NCT02520180). During a predefined four-week period data were recorded prospectively on all PCIs performed in the participating centers, whether or not patients were enrolled in TARGET-AC. Data were collected on patient demographics, angiographic lesion- and procedural characteristics. For patients who were not enrolled in the study, operators were asked to declare the reason for not enrolling the patient, using a single-choice questionnaire. RESULTS: A total of 131 patients were enrolled in the TARGET-AC study during the investigated period (ER group), standing as 20% (range 4% and 54%) of all eligible cases per protocol. In the ER group more patients presented with stable angina (61% vs. 43%, respectively; P < .001). Whereas ST-elevation infarction was less common (5% vs. 26%, respectively; P < .001), there was no difference in non-ST elevation acute coronary syndrome (32% vs. 27%, respectively; P = .248). Risk factors and comorbidities did not show any difference between the ER and the non-enrolled (NER) groups, except for greater rate of significant valvular disease in the NER group (12% vs 19%, respectively; P = .037). The NER group presented more thrombotic stenoses than the ER group (20% vs 12%, respectively; P = .040). No difference was found in any other investigated angiographic parameters, like target vessels, bifurcation lesion, severe calcification or chronic total occlusions. Admission during regular working hours and availability of study nurse were associated with mark
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- 2020
22. Safety and efficacy of a bioabsorbable polymer-coated, everolimus-eluting coronary stent in patients with diabetes: The EVOLVE II diabetes substudy.
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Christen T., Janssens L., Dawkins K.D., Windecker S., Kereiakes D.J., Meredith I.T., Masotti M., Carrie D., Moreno R., Erglis A., Mehta S.R., Elhadad S., Berland J., Stein B., Airaksinen J., Jobe R.L., Reitman A., Christen T., Janssens L., Dawkins K.D., Windecker S., Kereiakes D.J., Meredith I.T., Masotti M., Carrie D., Moreno R., Erglis A., Mehta S.R., Elhadad S., Berland J., Stein B., Airaksinen J., Jobe R.L., and Reitman A.
- Abstract
Aims: Bioabsorbable polymer drug-eluting stents (DES) may reduce the inflammation and delayed healing associated with some permanent polymer-coated DES. Whether late clinical outcomes are improved, particularly among patients with medically treated diabetes, is unknown. Therefore, we analysed outcomes from a pre-specified substudy of the EVOLVE II trial to evaluate the safety and effectiveness of the SYNERGY stent in patients with diabetes mellitus. Methods and Results: SYNERGY is a thin-strut, platinum-chromium everolimus-eluting stent with an ultra-thin bioabsorbable poly(DL-lactide-co-glycolide) abluminal polymer. The EVOLVE II randomised, controlled trial proved the non-inferiority of the SYNERGY versus the PROMUS Element Plus stent for one-year target lesion failure (TLF: ischaemia-driven target lesion revascularisation [ID-TLR], target vessel myocardial infarction [TVMI], or cardiac death). The pre-specified EVOLVE II diabetes substudy prospectively pooled randomised patients with diabetes (N=263) with a sequential single-arm diabetic cohort (n=203). The substudy primary endpoint was one-year TLF compared with a pre-specified performance goal (14.5%). The primary endpoint occurred in 7.5% of SYNERGY-treated patients with diabetes, significantly less than the performance goal (p<0.0001). The two-year rate of TLF was 11.2% (cardiac death 1.5%, TVMI 6.4%, ID-TLR 6.8%) and definite/probable stent thrombosis occurred in 1.1% of patients. Conclusion(s): The EVOLVE II diabetes substudy demonstrates the efficacy and safety of the SYNERGY stent in patients with medically treated diabetes. Clinical Trial Registration Information: NCT01665053 (http://clinicaltrials.gov/).Copyright © Europa Digital & Publishing 2017. All rights reserved.
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- 2020
23. Visie op de collectieve mondzorg voor kwetsbare ouderen: eendracht maakt macht
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Visser, A, Bakker, M H, Niesten, D, Janssens, L, Palmers, E, Duyck, J, Bots-van 't Spijker, P C, Bruers, J J M, van der Maarel-Wierink, C D, and Maintaining oral health and oral function
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Aged, 80 and over ,Self Care ,stomatognathic diseases ,Frail Elderly ,Health Personnel ,Humans ,Oral Health ,Aged - Abstract
Oral health in frail older people is often poor. There are a number of reasons for this, such as increased morbity and decreased motivation for (self) care. Good oral health is, however, very important. Studies have revealed poor oral health to cause or aggravate several medical and psychological problems. Illness and medication can, in turn, damage oral health. Oral health among the elderly should therefore be carefully monitored and maintained. This requires multidisciplinary and interprofessional collaboration on the part of healthcare professionals and others involved. Such collaboration is now still very limited; hardly anything has been written about how such collaboration in the area of oral care for frail older people should or could be organised. This article provides an overview of the possibilities and the relevant factors in the area of oral care for the elderly in promoting collaboration among healthcare professionals and others involved. All of this is under the banner of 'united we stand'.
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- 2019
24. A foldable type of emergence trap
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De Meyer, M, De Bruyn, L, Janssens, L, and BioStor
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- 1985
25. On-site rapid molecular testing, mobile sampling teams and eHealth to support primary care physicians during the COVID-19 pandemic
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Cheung, N.N., primary, Boers, S.A., additional, deh Kiani, S. Kiani, additional, Jansen, R.W., additional, Mook-Kanamori, D.O., additional, Janssens, L., additional, Feltkamp, M.C.W., additional, Kroes, A.C.M, additional, and Mourik, B.C., additional
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- 2020
- Full Text
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26. Translatability of non-clinical and clinical imaging data to clinical efficacy: S18.4
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de Boer, P, Langlois, X, Willems, L, Mannaert, E, Janssens, L, Streffer, J, van Nueten, L, and Schmidt, M
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- 2008
27. Benefit and Risks of Aspirin in Addition to Ticagrelor in Acute Coronary Syndromes: A Post Hoc Analysis of the Randomized GLOBAL LEADERS Trial
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Tomaniak, M, Chichareon, P, Onuma, Y, Deliargyris, EN, Takahashi, K, Kogame, N, Modolo, R, Chang, CC, Rademaker-Havinga, T, Storey, RF, Dangas, GD, Bhatt, DL, Angiolillo, DJ, Hamm, C, Valgimigli, M, Windecker, S, Steg, PG, Vranckx, P, Serruys, PW, Bertrand, OF, Plante, S, Van Geuns, RJ, Hofma, SH, Royaards, KJ, Slagboom, T, Suryapranata, H, Umans, VAWM, Rensing, B, van der Harst, P, Magro, M, Barbato, E, Aminian, A, Benit, E, Janssens, L, Vrolix, M, Buysschaert, I, Carrie, D, Barraud, P, Teiger, E, Koning, R, Farzin, B, Morelle, JF, Isaaz, K, Maillard, L, Abdellaoui, M, Brunel, P, Angioi, M, Lantelme, P, Sabate, M, Gonzalez-Trevilla, AA, Cequier, A, Iiguez, A, Penaranda, AS, Miguel, CM, Diaz, JF, Antolin, RAH, Goicolea, J, Ribeiro, VG, da Silva, PC, Ferreira, RC, Almeida, M, Ungi, I, Merkely, B, Fontos, G, Horvath, I, Koszegi, Z, Jambrik, Z, Edes, I, Jozsef, F, Colombo, A, Bolognese, L, Ferrario, M, Tumscitz, C, Dominici, M, Curello, S, Roffi, M, Eeckhout, E, Moccetti, T, Moschovitis, A, Leibundgut, G, Huber, K, Frey, B, Delle Karth, G, Friedrich, G, Steinwender, C, Zweiker, R, Stables, R, Anderson, R, Chowdhary, S, Garg, S, Hildick-Smith, D, Fath-Ordoubadi, F, Oldroyd, KG, Galasko, G, Kukreja, N, Zaman, A, Subkovas, E, Curzen, N, Hoole, S, Talwar, S, Walsh, S, Adlam, D, Cotton, J, Holmvang, L, Ottesen, MM, Buszman, P, Zurakowski, A, Galuszka, G, Prokopczuk, J, Zmudka, K, Jasionowicz, P, Mlodziankowski, A, Liebetrau, C, Naber, CK, Neumann, FJ, Schchinger, V, Seidler, T, Ibrahim, K, Zrenner, B, Gori, T, Werner, N, Akin, I, Geisler, T, vom Dahl, J, Haude, M, Eitel, I, Krackhardt, F, Jung, W, Neto, PAL, Sousa, A, Quintella, EF, Leandro, S, Botelho, R, Raffel, C, Barlis, P, Hai, KT, Ong, P, Petrov, I, Konteva, M, Velchev, V, Gelev, V, Tonev, G, Valkov, V, Vassilev, D, and Trendafilova-Lazarova, D
- Abstract
Key PointsQuestionWhat are the benefits and risks of continuing aspirin in addition to P2Y12 receptor inhibition with ticagrelor among patients with acute coronary syndrome between 1 month and 12 months after percutaneous coronary intervention? FindingsIn this nonprespecified, post hoc analysis of the GLOBAL LEADERS randomized clinical trial, beyond 1 month after percutaneous coronary intervention in acute coronary syndrome, aspirin was associated with increased bleeding risk and appeared not to add to the benefit of ticagrelor on ischemic events. MeaningThe findings of this hypothesis-generating analysis pave the way for further trials evaluating aspirin-free antiplatelet strategies after percutaneous coronary intervention. ImportanceThe role of aspirin as part of antiplatelet regimens in acute coronary syndromes (ACS) needs to be clarified in the context of newer potent P2Y12 antagonists. ObjectiveTo evaluate the benefit and risks of aspirin in addition to ticagrelor among patients with ACS beyond 1 month after percutaneous coronary intervention (PCI). Design, Setting, and ParticipantsThis is a nonprespecified, post hoc analysis of GLOBAL LEADERS, a randomized, open-label superiority trial comparing 2 antiplatelet treatment strategies after PCI. The trial included 130 secondary/tertiary care hospitals in different countries, with 15991 unselected patients with stable coronary artery disease or ACS undergoing PCI. Patients had outpatient visits at 1, 3, 6, 12, 18, and 24 months after index procedure. InterventionsThe experimental group received aspirin plus ticagrelor for 1 month followed by 23-month ticagrelor monotherapy; the reference group received aspirin plus either clopidogrel (stable coronary artery disease) or ticagrelor (ACS) for 12 months, followed by 12-month aspirin monotherapy. In this analysis, we examined the clinical outcomes occurring between 31 days and 365 days after randomization, specifically in patients with ACS who, within this time frame, were assigned to receive either ticagrelor alone or ticagrelor and aspirin. Main Outcomes and MeasuresThe primary outcome was the composite of all-cause death or new Q-wave myocardial infarction. ResultsOf 15968 participants, there were 7487 patients with ACS enrolled; 3750 patients were assigned to the experimental group and 3737 patients to the reference group. Between 31 and 365 days after randomization, the primary outcome occurred in 55 patients (1.5%) in the experimental group and in 75 patients (2.0%) in the reference group (hazard ratio [HR], 0.73; 95% CI, 0.51-1.03; P=.07); investigator-reported Bleeding Academic Research Consortium-defined bleeding type 3 or 5 occurred in 28 patients (0.8%) in the experimental group and in 54 patients (1.5%) in the reference arm (HR, 0.52; 95% CI, 0.33-0.81; P=.004). Conclusions and RelevanceBetween 1 month and 12 months after PCI in ACS, aspirin was associated with increased bleeding risk and appeared not to add to the benefit of ticagrelor on ischemic events. These findings should be interpreted as exploratory and hypothesis generating; however, they pave the way for further trials evaluating aspirin-free antiplatelet strategies after PCI. Trial RegistrationClinicalTrials.gov identifier: NCT01813435. This secondary analysis of the GLOBAL LEADERS randomized clinical trial evaluates the benefit and risks of aspirin in addition to ticagrelor among patients with acute coronary syndrome beyond 1 month after percutaneous coronary intervention.
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- 2019
28. Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment
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Sen, S, Ahmad, Y, Dehbi, H-M, Howard, JP, Iglesias, JF, Al-Lamee, R, Petraco, R, Nijjer, S, Bhindi, R, Lehman, S, Walters, D, Sapontis, J, Janssens, L, Vrints, CJ, Khashaba, A, Laine, M, Van Belle, E, Krackhardt, F, Bojara, W, Going, O, Härle, T, Indolfi, C, Niccoli, G, Ribichini, F, Tanaka, N, Yokoi, H, Takashima, H, Kikuta, Y, Erglis, A, Vinhas, H, Silva, PC, Baptista, SB, Alghamdi, A, Hellig, F, Koo, B-K, Nam, C-W, Shin, E-S, Doh, J-H, Brugaletta, S, Alegria-Barrero, E, Meuwissen, M, Piek, JJ, Van Royen, N, Sezer, M, Di Mario, C, Gerber, RT, Malik, IS, Sharp, ASP, Talwar, S, Tang, K, Samady, H, Altman, J, Seto, AH, Singh, J, Jeremias, A, Matsuo, H, Kharbanda, RK, Patel, MR, Serruys, P, Escaned, J, Davies, JE, The Academy of Medical Sciences, National Institute for Health Research, and Imperial College Healthcare Charity Grant
- Subjects
Male ,coronary stenosis ,Middle Aged ,Coronary Angiography ,instantaneous wave-free ratio ,1102 Cardiovascular Medicine And Haematology ,Coronary Vessels ,Fractional Flow Reserve, Myocardial ,1117 Public Health And Health Services ,Cardiovascular System & Hematology ,fractional flow reserve ,Myocardial Revascularization ,Humans ,Female ,cardiovascular diseases ,Aged - Abstract
BACKGROUND: Physicians are not always comfortable deferring treatment of a stenosis in the left anterior descending (LAD) artery because of the perception that there is a high risk of major adverse cardiac events (MACE). The authors describe, using the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) trial, MACE rates when LAD lesions are deferred, guided by physiological assessment using fractional flow reserve (FFR) or the instantaneous wave-free ratio (iFR). OBJECTIVES: The purpose of this study was to establish the safety of deferring treatment in the LAD using FFR or iFR within the DEFINE-FLAIR trial. METHODS: MACE rates at 1 year were compared between groups (iFR and FFR) in patients whose physiological assessment led to LAD lesions being deferred. MACE was defined as a composite of cardiovascular death, myocardial infarction (MI), and unplanned revascularization at 1 year. Patients, and staff performing follow-up, were blinded to whether the decision was made with FFR or iFR. Outcomes were adjusted for age and sex. RESULTS: A total of 872 patients had lesions deferred in the LAD (421 guided by FFR, 451 guided by iFR). The event rate with iFR was significantly lower than with FFR (2.44% vs. 5.26%; adjusted HR: 0.46; 95% confidence interval [CI]: 0.22 to 0.95; p = 0.04). This was driven by significantly lower unplanned revascularization with iFR and numerically lower MI (unplanned revascularization: 2.22% iFR vs. 4.99% FFR; adjusted HR: 0.44; 95% CI: 0.21 to 0.93; p = 0.03; MI: 0.44% iFR vs. 2.14% FFR; adjusted HR: 0.23; 95% CI: 0.05 to 1.07; p = 0.06). CONCLUSIONS: iFR-guided deferral appears to be safe for patients with LAD lesions. Patients in whom iFR-guided deferral was performed had statistically significantly lower event rates than those with FFR-guided deferral.
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- 2019
29. Incontinent Women Have Altered Pelvic Floor Muscle Contraction Patterns
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Devreese, A., Staes, F., Janssens, L., Penninckx, F., Vereecken, R., and De Weerdt, W.
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- 2007
30. Dual antiplatelet therapy duration after coronary stenting in clinical practice: results of an EAPCI survey
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Valgimigli, M, Costa, F, Byrne, R, Haude, M, Baumbach, A, Windecker, S, Aaroe, J, Aasa, M, Abdel-Salam, Am, Alaarag, Af, Accardi, R, Adel, A, Alcazar De La Torre, E, Alejos, R, Alfonso Jimenez, V, Alhashimi, Hmm, Aljeboury, A, Almeida De Sousa, J, Almusawi, A, Alshaikha, M, Altaf, S, Altahmody, Kea, Alvarez Contreras, Lr, Amarasena, N, Amoroso, G, Anderson, R, Ando, G, Andrade, J, Andreou, Ay, Angulo, J, Antonio, T, Aprigliano, G, Aquilina, M, Arafa, Seo, Aramberry, L, Arampatzis, Ca, Araujo, Jj, Asher, E, Ates, I, Athanasias, D, Auer, J, Auffret, V, Ayala, Fj, Baba, C, Baglioni, P, Bagur, R, Balam-Ortiz, E, Balducelli, M, Bam Pas, G, Barbash, Im, Barbosa, Ahp, Barbosa, R, Barnay, P, Barroso, L, Basti, A, Bax, M, Bayet, G, Beijk, Ma, Beltran, R, Berenguer Jofresa, A, Berroth, R, Berti, S, Berumen Dominguez, Le, Bhasin, A, Bhaya, M, Bianco, M, Biasco, L, Bikicki, M, Bonarjee, Vvs, Bonechi, F, Borges Santos, M, Boshev, M, Bouferrouk, A, Bounartzidi, M, Bousoula, E, Brie, D, Brtko, M, Brugaletta, S, Brull, Dj, Buchter, B, Buendia, R, Burzotta, F, Butz, T, Buzzetti, F, Bychowiec, B, Cadeddu, M, Campanile, A, Carneiro, Jg, Carrilho-Ferreira, P, Carrillo Guevara, Je, Carter, Aj, Casal-Heredia, H, Castiglioni, B, Castro Fabiano, L, Cavalcante Silva, R, Cavalcanti De Oliveira, D, Cavalcanti, Rc, Cavazza, C, Centemero, Mp, Chabane, Hk, Chamie, D, Chatzis, D, Chaves, Aj, Cheng, S, Chinchilla, H, Ciabatti, N, Cirillo, P, Citaku, H, Claeys, Mj, Clifford, C, Coceani, M, Coggiola, J, Cohen, Dj, Conway, Dsg, Cornelis, K, Coroleu, Sf, Corral, Jm, Cortese, B, Coskun, U, Costa, Ra, Coste, P, Coufal, Z, Cox, S, Cozma, A, Crean, P, Crenshaw, Mh, Cristian, U, Cruz-Alvarado, Je, Cuculi, F, Cuenza, L, Cyrne Carvalho, H, D'Ascenzo, F, D'Urbano, M, Damonte, A, Dan Florin, F, Dana, A, Dangoisse, V, De Backer, O, De Cock, D, De Vita, M, Debski, A, Delgado, A, Devadathan, S, Dhamrait, S, Di Lorenzo, E, Di Serafino, D, Diego-Nieto, A, Dievart, F, Diez, Jl, Dimitriadis, K, Dina, C, Doerner, O, Donahue, M, Donis, J, Drieghe, B, Drissi, Mf, Du Fretay, H, Dziewierz, A, Echavarria-Pinto, M, Echeverria Romero, Rg, Economou, F, Eftychiou, C, Egdell, R, El Hosieny, A, El Meguid, K, Elabbassi, W, Elesgerli, S, Elghetany, H, Elizondo, Jc, Elkahlout, A, Elrowiny, R, Elserafy, As, Emam, A, Emara, A, Emmanouil, P, Ercilla, J, Erglis, A, Eslam Taha, E, Esmaeil, S, Esposito, G, Ettori, F, Eugenio, N, Everaert, B, Ezquerra Aguilar, W, Falu, R, Farag, E, Farjalla, J, Feldman, L, Feldman, M, Felice, H, Fernandez-Nofrerias, E, Fernandez-Rodriguez, D, Ferranti, F, Ferreira, Q, Ferrone, M, Fleischmann, C, Flessas, D, Formigli, D, Fozilov, H, Fraccaro, C, Freitas, Jo, Fresco, C, Fridrich, V, Furmaniuk, J, Gagnor, A, Galasso, G, Galeazzi, Gl, Galli, S, Galvez Villacorta, V, Gandolfo, C, Garcia, E, Garcia-Blas, S, Garducci, S, Garg, S, Garro, N, Gatto, L, Georgiou, Mg, Ghanem, I, Ghose, T, Giacchi, G, Giang, Pt, Giesler, T, Giovino, M, Girardi, P, Girasis, C, Giunio, L, Giustino, G, Glatthor, C, Glogar, Hd, Golledge, P, Gomez Moreno, J, Gomez Recio, M, Gommeaux, A, Grantalis, G, Greco, F, Grundeken, Mj, Grunert, S, Gudmundsdottir, I, Guenoun, M, Guerios, E, Gupta, R, Gupta, S, Gutierrez, C, Hafeez, I, Halvorsen, S, Hamed Hussein, Ga, Hammoudeh, A, Hansen, Pr, Harb, S, Hawas, Jm, Hayrapetyan, H, Heintzen, Mp, Hengstenberg, C, Herity, N, Hernandez, F, Heyse, A, Hicham, D, Hildick-Smith, D, Hill, J, Hillani, A, Hiltrop, N, Hiramori, A, Hobson, Ar, Homan, Dj, Hooda, A, Ielasi, A, Ierna, S, Iftikhar, Ak, Ilic, I, Imai, Y, Imperadore, F, Indolfi, C, Iorga, V, Ipek, E, Ito, S, Jacksch, R, Jae-Sik, J, James, S, Jamshidi, P, Jerbi, J, Jimenez Quevedo, P, Jimenez-Navarro, M, Jimenez-Santos, M, Jin, Qh, Joksas, V, Jovic, D, Junejo, S, Kallel, R, Kamal, A, Kamiya, H, Kannan, D, Kantaria, M, Kapetanopoulos, A, Kara Ali, B, Karjalainen, Pp, Karthikeyan, Vj, Kato, R, Katsikis, A, Kefer, J, Keta, D, Ketteler, T, Khan, M, Kharlamov, A, Kinani, A, Kinani, T, Kinnaird, T, Kislo, A, Kiviniemi, 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Cg, Laanmets, P, Labrunie, A, Ladwiniec, A, Lai, G, Laine, M, Latib, A, Lattuca, B, Lazarevic, Am, Lee, Ks, Legrand, V, Leiva, G, Lester, N, Levchyshyna, O, Livia, G, Londero, Hf, Luha, O, Lupi, A, Lupkovics, G, Maaliki, S, Maeng, M, Mahr, Nc, Mantyla, P, Mariano, E, Marsit, N, Mcdonough, Tj, Medda, M, Mejia Viana, S, Merigo Azpir, Ca, Mitreski, S, Moreno, R, Moreu, J, Muehler, M, Muir, D, Munoz Molina, R, Musilli, N, Myc, J, Nadra, I, Nagy, Cd, Narayanan, A, Neugebauer, P, Nguyen, M, Nick, H, Nicolino, A, Obradovic, Sd, Paizis, I, Panagiotis, P, Park, Sd, Park, Sj, Pasquetto, G, Patel, D, Paunovic, D, Pedon, L, Pereira Machado, F, Pershukov, H, Petrou, E, Pinton, Fa, Preti, G, Puri, R, Pyxaras, Sa, Quintanilla, J, Rhouati, A, Ribeiro De Oliveira, I, Rivetti, L, Rodriguez, Ae, Rotevatn, S, Rubartelli, P, Sachdeva, R, Sanchez-Perez, H, Sangiorgi, G, Santoro, Gm, Saporito, F, Scappaticci, M, Schmermund, A, Schmidt, Je, Schmitz, T, Schneider, Ti, Schuchlenz, H, Sepulveda Varela, P, Shaw, 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M., Alaarag, A. F., Accardi, R., Adel, A., Alcazar De La Torre, E., Alejos, R., Alfonso Jimenez, V., Alhashimi, H. M. M., Aljeboury, A., Almeida De Sousa, J., Almusawi, A., Alshaikha, M., Altaf, S., Altahmody, K. E. A., Alvarez Contreras, L. R., Amarasena, N., Amoroso, G., Anderson, R., Ando, G., Andrade, J., Andreou, A. Y., Angulo, J., Antonio, T., Aprigliano, G., Aquilina, M., Arafa, S. E. O., Aramberry, L., Arampatzis, C. A., Araujo, J. J., Asher, E., Ates, I., Athanasias, D., Auer, J., Auffret, V., Ayala, F. J., Baba, C., Baglioni, P., Bagur, R., Balam-Ortiz, E., Balducelli, M., Bam Pas, G., Barbash, I. M., Barbosa, A. H. P., Barbosa, R., Barnay, P., Barroso, L., Basti, A., Bax, M., Bayet, G., Beijk, M. A., Beltran, R., Berenguer Jofresa, A., Berroth, R., Berti, S., Berumen Dominguez, L. E., Bhasin, A., Bhaya, M., Bianco, M., Biasco, L., Bikicki, M., Bonarjee, V. V. S., Bonechi, F., Borges Santos, M., Boshev, M., Bouferrouk, A., Bounartzidi, M., Bousoula, E., Brie, D., Brtko, M., Brugaletta, S., Brull, D. J., Buchter, B., Buendia, R., Burzotta, F., Butz, T., Buzzetti, F., Bychowiec, B., Cadeddu, M., Campanile, A., Carneiro, J. G., Carrilho-Ferreira, P., Carrillo Guevara, J. E., Carter, A. J., Casal-Heredia, H., Castiglioni, B., Castro Fabiano, L., Cavalcante Silva, R., Cavalcanti De Oliveira, D., Cavalcanti, R. C., Cavazza, C., Centemero, M. P., Chabane, H. K., Chamie, D., Chatzis, D., Chaves, A. J., Cheng, S., Chinchilla, H., Ciabatti, N., Cirillo, P., Citaku, H., Claeys, M. J., Clifford, C., Coceani, M., Coggiola, J., Cohen, D. J., Conway, D. S. G., Cornelis, K., Coroleu, S. F., Corral, J. M., Cortese, B., Coskun, U., Costa, R. A., Coste, P., Coufal, Z., Cox, S., Cozma, A., Crean, P., Crenshaw, M. H., Cristian, U., Cruz-Alvarado, J. E., Cuculi, F., Cuenza, L., Cyrne Carvalho, H., D'Ascenzo, F., D'Urbano, M., Damonte, A., Dan Florin, F., Dana, A., Dangoisse, V., De Backer, O., De Cock, D., De Vita, M., Debski, A., Delgado, A., Devadathan, S., Dhamrait, S., Di Lorenzo, E., Di Serafino, D., Diego-Nieto, A., Dievart, F., Diez, J. L., Dimitriadis, K., Dina, C., Doerner, O., Donahue, M., Donis, J., Drieghe, B., Drissi, M. F., Du Fretay, H., Dziewierz, A., Echavarria-Pinto, M., Echeverria Romero, R. G., Economou, F., Eftychiou, C., Egdell, R., El Hosieny, A., El Meguid, K., Elabbassi, W., Elesgerli, S., Elghetany, H., Elizondo, J. C., Elkahlout, A., Elrowiny, R., Elserafy, A. S., Emam, A., Emara, A., Emmanouil, P., Ercilla, J., Erglis, A., Eslam Taha, E., Esmaeil, S., Esposito, G., Ettori, F., Eugenio, N., Everaert, B., Ezquerra Aguilar, W., Falu, R., Farag, E., Farjalla, J., Feldman, L., Feldman, M., Felice, H., Fernandez-Nofrerias, E., Fernandez-Rodriguez, D., Ferranti, F., Ferreira, Q., Ferrone, M., Fleischmann, C., Flessas, D., Formigli, D., Fozilov, H., Fraccaro, C., Freitas, J. O., Fresco, C., Fridrich, V., Furmaniuk, J., Gagnor, A., Galasso, G., Galeazzi, G. L., Galli, S., Galvez Villacorta, V., Gandolfo, C., Garcia, E., Garcia-Blas, S., Garducci, S., Garg, S., Garro, N., Gatto, L., Georgiou, M. G., Ghanem, I., Ghose, T., Giacchi, G., Giang, P. T., Giesler, T., Giovino, M., Girardi, P., Girasis, C., Giunio, L., Giustino, G., Glatthor, C., Glogar, H. D., Golledge, P., Gomez Moreno, J., Gomez Recio, M., Gommeaux, A., Grantalis, G., Greco, F., Grundeken, M. J., Grunert, S., Gudmundsdottir, I., Guenoun, M., Guerios, E., Gupta, R., Gupta, S., Gutierrez, C., Hafeez, I., Halvorsen, S., Hamed Hussein, G. A., Hammoudeh, A., Hansen, P. R., Harb, S., Hawas, J. M., Hayrapetyan, H., Heintzen, M. P., Hengstenberg, C., Herity, N., Hernandez, F., Heyse, A., Hicham, D., Hildick-Smith, D., Hill, J., Hillani, A., Hiltrop, N., Hiramori, A., Hobson, A. R., Homan, D. J., Hooda, A., Ielasi, A., Ierna, S., Iftikhar, A. K., Ilic, I., Imai, Y., Imperadore, F., Indolfi, C., Iorga, V., Ipek, E., Ito, S., Jacksch, R., Jae-Sik, J., James, S., Jamshidi, P., Jerbi, J., Jimenez Quevedo, P., Jimenez-Navarro, M., Jimenez-Santos, M., Jin, Q. H., Joksas, V., Jovic, D., Junejo, S., Kallel, R., Kamal, A., Kamiya, H., Kannan, D., Kantaria, M., Kapetanopoulos, A., Kara Ali, B., Karjalainen, P. P., Karthikeyan, V. J., Kato, R., Katsikis, A., Kefer, J., Keta, D., Ketteler, T., Khan, M., Kharlamov, A., Kinani, A., Kinani, T., Kinnaird, T., Kislo, A., Kiviniemi, T., Kleiban, A., Kluck, B., Kocayigit, I., Kokis, A., Komiyama, N., Konstantinos, L., Kordalis, A., Kozak, M., Krecki, R., Kristensen, S. D., Krizanic, F., Krsticevic, L., Kuex, H., Kukreja, N., Kulic, M., Kulikovskikh, Y. V., Kulkarni, P., Kumar, N., Kumar Soni, A., Kuzmenko, E., L'Allier, P. L., Langner, O., Lapin, O., Lauer, B., Leclercq, F., Leibundgut, G., Leon Aliz, E., Leon, C., Leon, K., Leoncini, M., Leone, A. M., Leroux, L., Lesiak, M., Letilovic, T., Lev, E., Linares Vicente, J. A., Lindsay, S., Loh, P. H., Loncar, G., Loo, B., Lopez, M. B., Lopez-Cuellar, J., Lozano, I., Luigia, P., Lunde, K., Lyczywek, M., Macdougall, D., Mafrici, A., Magni, V., Magro, M., Mainar, V., Makarovic, Z., Malik, N., Maly, M., Mansour, S., Marenco, R. E., Maresta, A., Marinho, G. E., Marino, R. L., Marinucci, L., Martins, H. C., Martins, J., Mashayekhi, K., Masood, A., Maurer, E., Mavrogianni, A. D., Mazurek, T., Medina, A., Mehilli, J., Mellwig, K. P., Mendez, M., Mendiz, O. A., Meneses, A., Mercado, L. A., Mereuta, A., Mezzapelle, G., Milanovic, N., Mohamed, S. M., Mohanad, A., Mohanty, A., Moorthy, N., Morales, F. J., More, R., Moreno Samos, J. C., Moreno-Martinez, F. L., Moscato, F., Mossmann, M., Mrevlje, B., Muller-Eichelberg, A., Musumeci, G., Nadir Khan, M., Najim, S., Nakamura, S., Nakao, F., Naveri, H., Negus, B., Nerla, R., Nguyen, H. T., Niess, G. S., Nikas, D. N., Niroomand, F., Niva, J., Nogueira, J. W., Nombela-Franco, L., Notrica, M., Nouri, B., Nugue, O., Nunes, G. L., Ober, M., Ochoa, J., Oh, J. H., Ojeda, S., Oktay Tureli, H., Olowe, Y., Oluseun, A., Opolski, G., Ornelas, C. E., Otasevic, P., Ozturk, A., Padilla, F., Pagny, J. Y., Paolantonio, D., Papaioannou, G. I., Parodi, G., Patil, S. N., Pavei, A., Pavia, A., Pavlidis, A., Pell, A., Percoco, G. F., Pernasetti, L. V., Pescoller, F., Petropoulakis, P., Piatti, L., Picardi, E., Pieroni, D. M., Pina, J., Pinheiro, L. F., Pinto, F. J., Pipa, J. L., Piroth, Z., Pisano, F., Podbregar, M., Polak, G., Polimeni, A., Postadzhiyan, A., Postu, M., Poulimenos, L. E., Pow Chon Long, F., Poyet, R., Pradhan, A., Predescu, L. M., Prida, X. E., Saad, A., Prog, R., Pulikal, D. G. A., Qiangzhong, P. I., Radu, M. D., Rajendran, D., Ram Anil Raj, M. R., Ramazzotti, V., Rapacciuolo, A., Ratib, K., Raungaard, B., Raviola, E., Reppas, E., Reyes, J. A., Rezek, M., Riess, G. J., Rifaie, O., Rigattieri, S., Rissanen, T., Ristic, A. D., Rittger, H., Roberts, J., Rodriguez Saavedra, A., Roik, M., Roshan Rao, K., Routledge, H., Rubboli, A., Rudolph, T., Rudzitis, A., Ruiters, A., Ruiz Ros, J. A., Ruiz-Garcia, J., Ruiz-Nodar, J. M., Sabate, M., Sabnis, G., Sabouret, P., Sacra, C., Saghatelyan, M., Sahin, M., Said, S., Salachas, A. J., Salas Llamas, J. P., Salih, A., Sanchez, O. D., Sanchez-Gila, J., Sanchez-Perez, I., Santarelli, A., Sardovski, Sarenac, D., Sarma, J., Sarno, G., Savonitto, S., Sayied Abdullah, A., Schafer, A., Scherillo, M., Schneider, H., Schuhlen, H., Sciahbasi, A., Seca, L., Sedlon, P., Semenka, J., Serra, L. A., Sesana, M., Sethi, A., Sgueglia, G. A., Shaheen, S., Shahri, H., Sheiban, I., Shyu, K. G., Silva, C. E. F., Sionis, D., Siqueira, D. A., Siqueira, M. J., Smits, P., Sobhy, M., Sokolov, M., Soliman, S., Somani, A. N., Sridhar, G., Stakos, D., Stasek, J., Stefanini, G., Steigen, T. K., Stewart, Stipal, R., Stochino, M. L., Stoel, M. G., Subla, R. M., Suliman, A., Summaria, F., Stoyanov, N., Syed, A. A., Tanaka, Y., Tashani, A., Tauzin, S., Tawade, N., Tawfik, M., Tayeh, O., Terzic, I., Testa, L., Thevan, B., Thiam, M., Tiecco, F., Tierala, I., Tilea, I., Tilsted, H. H., Tomasik, A. R., Tonev, I., Torres Bosco, A., Tousek, P., Townend, J., Tran Ngoc, T., Triantafyllou, K., Tsigkas, G., Tsioufis, C., Turri, M., Tyligadis, G., Ugo, F., Ultramari, F. T., Urban, P., Uren, N., Uretsky, B. F., Uribe, C. E., Usman, B., Valadez Molina, F., Van Houwelingen, K. G., Vandormael, M., Varvarovsky, I., Vassilis, V., Velasquez, D., Verdoia, M., Vermeersch, P., Vidal-Perez, R., Vinesh, J., Violini, R., Vista, J. H., Vogt, F., Vogt, M., Vokac, D., Vom Dahl, J., Vranckx, P., Wahab, A., Wang, R., Wang, T. D., Wani, S., Weisz, S. H., Werner, G. S., Wilkinson, J. R., Wolf, A., Youssef, A., Yumoto, K., Zaderenko, N., Zaghloul Darwish, A. M., Zahn, R., Zaro, T., Zavalloni, D., Zbinden, R., Zekanovic, D., Zhang, B., Zhang, C., Zhang, Y. J., Zhonghan, N., Zingarelli, A., Zueco, J., Zuhairy, H., Abbate, A., Abdel Hamid, M., Abdelmegid, M. A. F., Acuna-Valerio, J., Adriaenssens, T., Agostoni, P., Aikot, H., Alameda, M., Alcaraz, H., Almendro-Delia, M., Altug Cakmak, H., Amir, A., Arjomand, A., Assomull, R., Atalar, E., Avramides, D., Aytek Simsek, M., Aznaouridis, K., Azpeitia, Y., Barnabas, C., Barsness, G. W., Bartorelli, A. L., Basoglu, A., Benezet, J., Benincasa, S., Berland, J., Berrocal, D. H., Bett, N., Boskovic, S., Brandao, V., Caporale, R., Caprotta, F., Carrabba, N., Cazaux, P., Cheniti, G., Chinchilla Calix, H., Chung, W. Y., Cicco, N. A., Cieza, T., Clapp, B., Commeau, P., Cuellar, C., De Benedictis, M., De La Torre Hernandez, J. M., De Vroey, F., Degertekin, M., Eberli, F. R., Eggebrecht, H., Ekicibasi, E., Elmaraghi, M., Elod, P., Ergene, A. O., Fadlalla, V. F., Farah, M. A., Fernandez Vina, R., Ferro, A., Fischer, D., Flore, V., Foley, D. P., Gafoor, S., Gallo, S., Gaspardone, A., Gavrilescu, D., Gentiletti, A., Gilard, M., Giovannelli, F., Gonzalez Pacheco, I., Gonzalo, N., Grajek, S., Gurgel De Medeiros, J. P., Haine, S., Hakim, D., Hakim Vista, J. J., Hallani, H., Hamid, M., Helft, G., Heppell, R. M., Hernandez-Enriquez, M., Hlinomaz, O., Ho Choo, E., Huqi, A., Hurtado, E. O., Iakovou, I., Iosseliani, D., Janssens, L., Jean, M., Jensen, J. K., Jesudason, P., Jimenez Diaz, V. A., Karchevsky, D., Karpovskii, A., Katsimagklis, G., Kereiakes, D., Kersanova, N. C., Kesavan, S., Khaled, H., Khalil, S. A., Kiatchoosakun, S., Kim, K. S., Kirma, C., Koltowski, L., Konteva, M., Kozinski, L., Kuehn, C. R., Kumar, S., Kyriakakis, C. G., Laanmets, P., Labrunie, A., Ladwiniec, A., Lai, G., Laine, M., Latib, A., Lattuca, B., Lazarevic, A. M., Lee, K. S., Legrand, V., Leiva, G., Lester, N., Levchyshyna, O., Livia, G., Londero, H. F., Luha, O., Lupi, A., Lupkovics, G., Maaliki, S., Maeng, M., Mahr, N. C., Mantyla, P., Mariano, E., Marsit, N., Mcdonough, T. J., Medda, M., Mejia Viana, S., Merigo Azpir, C. A., Mitreski, S., Moreno, R., Moreu, J., Muehler, M., Muir, D., Munoz Molina, R., Musilli, N., Myc, J., Nadra, I., Nagy, C. D., Narayanan, A., Neugebauer, P., Nguyen, M., Nick, H., Nicolino, A., Obradovic, S. D., Paizis, I., Panagiotis, P., Park, S. D., Park, S. J., Pasquetto, G., Patel, D., Paunovic, D., Pedon, L., Pereira Machado, F., Pershukov, H., Petrou, E., Pinton, F. A., Preti, G., Puri, R., Pyxaras, S. A., Quintanilla, J., Rhouati, A., Ribeiro De Oliveira, I., Rivetti, L., Rodriguez, A. E., Rotevatn, S., Rubartelli, P., Sachdeva, R., Sanchez-Perez, H., Sangiorgi, G., Santoro, G. M., Saporito, F., Scappaticci, M., Schmermund, A., Schmidt, J. E., Schmitz, T., Schneider, T. I., Schuchlenz, H., Sepulveda Varela, P., Shaw, E., Silva Marques, J., Skalidis, E., Slhessarenko, J., Spaulding, C., Stankovic, G., Suwannasom, P., Synetos, A., Szuster, E., Taha, S., Tavano, D., Tebet, M., Thury, A., Toutouzas, K., Triantafyllis, A. S., Tsikaderis, D., Tumscitz, C., Tzanogiorgis, I., Udovichenko, A., Ulrike, N., Unikas, R., Valerio, M. G., Van Mieghem, C., Vandendriessche, T., Vavlukis, M., Vigna, C., Vilar, J. V., Vizzari, G., Voudris, V., Wafa, S., Wagner, D. R., Wichter, T., Wiedemann, S., Williams, P. D., Woody, W., Yding, A., Zachow, G., and Webster, M.
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Male ,medicine.medical_specialty ,Time Factors ,Percutaneous ,Time Factor ,Psychological intervention ,Alternative medicine ,MEDLINE ,Practice Patterns ,Drug Administration Schedule ,acute coronary syndrome ,Settore MED/11 ,Percutaneous Coronary Intervention ,Pharmacotherapy ,Drug Therapy ,Physicians ,Surveys and Questionnaires ,drug-eluting stent ,Humans ,Surveys and Questionnaire ,Medicine ,Practice Patterns, Physicians' ,health care economics and organizations ,clopidogrel ,dual antiplatelet therapy (DAPT) ,stable coronary artery disease ,Drug Therapy, Combination ,Evidence-Based Medicine ,Health Care Surveys ,Platelet Aggregation Inhibitors ,Practice Guidelines as Topic ,Practice Patterns, Physicians ,Treatment Outcome ,Stents ,business.industry ,Platelet Aggregation Inhibitor ,Coronary stenting ,Evidence-based medicine ,Middle Aged ,Surgery ,Clinical trial ,Health Care Survey ,Combination ,Emergency medicine ,Female ,Cardiology and Cardiovascular Medicine ,business ,Human - Abstract
AIMS Our aim was to report on a survey initiated by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) concerning opinion on the evidence relating to dual antiplatelet therapy (DAPT) duration after coronary stenting. METHODS AND RESULTS Results from three randomised clinical trials were scheduled to be presented at the American Heart Association Scientific Sessions 2014 (AHA 2014). A web-based survey was distributed to all individuals registered in the EuroIntervention mailing list (n=15,200) both before and after AHA 2014. A total of 1,134 physicians responded to the first (i.e., before AHA 2014) and 542 to the second (i.e., after AHA 2014) survey. The majority of respondents interpreted trial results consistent with a substantial equipoise regarding the benefits and risks of an extended versus a standard DAPT strategy. Two respondents out of ten believed extended DAPT should be implemented in selected patients. After AHA 2014, 46.1% of participants expressed uncertainty about the available evidence on DAPT duration, and 40.0% the need for clinical guidance. CONCLUSIONS This EAPCI survey highlights considerable uncertainty within the medical community with regard to the optimal duration of DAPT after coronary stenting in the light of recent reported trial results. Updated recommendations for practising physicians to guide treatment decisions in routine clinical practice should be provided by international societies.
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- 2015
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31. Automated Recording of Vertical Negative Phototactic Behaviour in Daphnia magna Straus (Crustacea)
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Gerhardt, A., de Bisthoven, Janssens L., and Schmidt, S.
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- 2006
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32. Chironomidae larvae as bioindicators of an acid mine drainage in Portugal
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De Bisthoven, Janssens L., Gerhardt, A., and Soares, A. M. V. M.
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- 2005
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33. 2-Year Clinical Outcomes of an Abluminal Groove-Filled Biodegradable-Polymer Sirolimus-Eluting Stent Compared With a Durable-Polymer Everolimus-Eluting Stent
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Xu, B., Saito, Y., Baumbach, A., Kelbaek, H., Royen, N. van, Zheng, M., Morel, M.A., Knaapen, P., Slagboom, T., Johnson, T.W., Vlachojannis, G., Arkenbout, K.E., Holmvang, L., Janssens, L., Ochala, A., Brugaletta, S., Naber, C.K., Anderson, R., Rittger, H., Berti, S., Barbato, E., Toth, G.G., Maillard, L., Valina, C., Buszman, P., Thiele, H., Schachinger, V., Lansky, A., Wijns, W., Xu, B., Saito, Y., Baumbach, A., Kelbaek, H., Royen, N. van, Zheng, M., Morel, M.A., Knaapen, P., Slagboom, T., Johnson, T.W., Vlachojannis, G., Arkenbout, K.E., Holmvang, L., Janssens, L., Ochala, A., Brugaletta, S., Naber, C.K., Anderson, R., Rittger, H., Berti, S., Barbato, E., Toth, G.G., Maillard, L., Valina, C., Buszman, P., Thiele, H., Schachinger, V., Lansky, A., and Wijns, W.
- Abstract
Item does not contain fulltext, OBJECTIVES: The aim of this study was to assess the 2-year clinical outcomes of the Firehawk stent (Shanghai MicroPort Medical Group, Shanghai, China), a novel abluminal groove-filled biodegradable-polymer sirolimus-eluting coronary stent, compared with XIENCE (Abbott Vascular, Santa Clara, California), a durable-polymer everolimus-eluting coronary stent. BACKGROUND: The long-term outcomes of the Firehawk stent have not been evaluated beyond 1 year in a randomized all-comers clinical trial. METHODS: The TARGET All Comers study is a prospective, multicenter, all-comers, randomized, noninferiority trial conducted in Europe. A total of 1,653 patients were randomly assigned to undergo implantation of either the Firehawk or the XIENCE stent. The primary endpoint was target lesion failure, a composite of cardiac death, target vessel myocardial infarction, or ischemia-driven target lesion revascularization. RESULTS: At 2-year follow-up, the incidence of target lesion failure was 8.7% in the Firehawk group versus 8.6% in the XIENCE group (p = 0.92). The event rates of individual components of the primary endpoint were comparable for the 2 groups. Landmark analyses between 1- and 2-year follow-up revealed no statistically significant difference of TLF for the Firehawk versus the XIENCE stent. Beyond 1 year, very late definite or probable stent thrombosis occurred in 3 patients (0.4%) in the Firehawk group and in 7 patients (0.9%) in the XIENCE group (p = 0.34). CONCLUSIONS: The 2-year follow-up of the TARGET All Comers study confirms comparable safety and efficacy profiles of the Firehawk and XIENCE stents.
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- 2019
34. Sex Differences in Instantaneous Wave-Free Ratio or Fractional Flow Reserve-Guided Revascularization Strategy
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Kim, C.H., Koo, B.K., Dehbi, H.M., Lee, J.M., Doh, J.H., Nam, C.W., Shin, E.S., Cook, C.M., Al-Lamee, R., Petraco, R., Sen, S., Malik, I.S., Nijjer, S.S., Mejia-Renteria, H., Alegria-Barrero, E., Alghamdi, A., Altman, J., Baptista, S.B., Bhindi, R., Bojara, W., Brugaletta, S., Silva, P.C., Mario, C. de, Erglis, A., Gerber, R.T., Going, O., Harle, T., Hellig, F., Indolfi, C., Janssens, L., Jeremias, A., Kharbanda, R.K., Khashaba, A., Kikuta, Y., Krackhardt, F., Laine, M., Lehman, S.J., Matsuo, H., Meuwissen, M., Niccoli, G., Piek, J.J., Ribichini, F., Samady, H., Sapontis, J., Seto, A.H., Sezer, M., Sharp, A.S.P., Singh, J., Takashima, H., Talwar, S., Tanaka, N., Tang, K., Belle, Eric van, Royen, N. van, Vinhas, H., Vrints, C.J., Walters, D., Yokoi, H., Samuels, B., Buller, C., Patel, M.R., Serruys, P.W., Escaned, J., Davies, J.E., Kim, C.H., Koo, B.K., Dehbi, H.M., Lee, J.M., Doh, J.H., Nam, C.W., Shin, E.S., Cook, C.M., Al-Lamee, R., Petraco, R., Sen, S., Malik, I.S., Nijjer, S.S., Mejia-Renteria, H., Alegria-Barrero, E., Alghamdi, A., Altman, J., Baptista, S.B., Bhindi, R., Bojara, W., Brugaletta, S., Silva, P.C., Mario, C. de, Erglis, A., Gerber, R.T., Going, O., Harle, T., Hellig, F., Indolfi, C., Janssens, L., Jeremias, A., Kharbanda, R.K., Khashaba, A., Kikuta, Y., Krackhardt, F., Laine, M., Lehman, S.J., Matsuo, H., Meuwissen, M., Niccoli, G., Piek, J.J., Ribichini, F., Samady, H., Sapontis, J., Seto, A.H., Sezer, M., Sharp, A.S.P., Singh, J., Takashima, H., Talwar, S., Tanaka, N., Tang, K., Belle, Eric van, Royen, N. van, Vinhas, H., Vrints, C.J., Walters, D., Yokoi, H., Samuels, B., Buller, C., Patel, M.R., Serruys, P.W., Escaned, J., and Davies, J.E.
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Item does not contain fulltext, OBJECTIVES: This study sought to evaluate sex differences in procedural characteristics and clinical outcomes of instantaneous wave-free ratio (iFR)- and fractional flow reserve (FFR)-guided revascularization strategies. BACKGROUND: An iFR-guided strategy has shown a lower revascularization rate than an FFR-guided strategy, without differences in clinical outcomes. METHODS: This is a post hoc analysis of the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate stenosis to guide Revascularization) study, in which 601 women and 1,891 men were randomized to iFR- or FFR-guided strategy. The primary endpoint was 1-year major adverse cardiac events (MACE), a composite of all-cause death, nonfatal myocardial infarction, or unplanned revascularization. RESULTS: Among the entire population, women had a lower number of functionally significant lesions per patient (0.31 +/- 0.51 vs. 0.43 +/- 0.59; p < 0.001) and less frequently underwent revascularization than men (42.1% vs. 53.1%; p < 0.001). There was no difference in mean iFR value according to sex (0.91 +/- 0.09 vs. 0.91 +/- 0.10; p = 0.442). However, the mean FFR value was lower in men than in women (0.83 +/- 0.09 vs. 0.85 +/- 0.10; p = 0.001). In men, an FFR-guided strategy was associated with a higher rate of revascularization than an iFR-guided strategy (57.1% vs. 49.3%; p = 0.001), but this difference was not observed in women (41.4% vs. 42.6%; p = 0.757). There was no difference in MACE rates between iFR- and FFR-guided strategies in both women (5.4% vs. 5.6%, adjusted hazard ratio: 1.10; 95% confidence interval: 0.50 to 2.43; p = 0.805) and men (6.6% vs. 7.0%, adjusted hazard ratio: 0.98; 95% confidence interval: 0.66 to 1.46; p = 0.919). CONCLUSIONS: An FFR-guided strategy was associated with a higher rate of revascularization than iFR-guided strategy in men, but not in women. However, iFR- and FFR-guided strategies showed comparable clinical outcomes, regardless of sex. (Functional Lesion Assessment of Inter
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- 2019
35. Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment
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Sen, S., Ahmad, Y., Dehbi, H.M., Howard, J.P., Iglesias, J.F., Al-Lamee, R., Petraco, R., Nijjer, S., Bhindi, R., Lehman, S., Walters, D., Sapontis, J., Janssens, L., Vrints, C.J., Khashaba, A., Laine, M., Belle, E, Krackhardt, F., Bojara, W., Going, O., Harle, T., Indolfi, C., Niccoli, G., Ribichini, F., Tanaka, N., Yokoi, H., Takashima, H., Kikuta, Y., Erglis, A., Vinhas, H., Silva, P.C., Baptista, S.B., Alghamdi, A., Hellig, F., Koo, B.K., Nam, C.W., Shin, E.S., Doh, J.H., Brugaletta, S., Alegria-Barrero, E., Meuwissen, M., Piek, J.J., Royen, N. van, Sezer, M., Mario, C. de, Gerber, R.T., Malik, I.S., Sharp, A.S.P., Talwar, S., Tang, K., Samady, H., Altman, J., Seto, A.H., Singh, J., Jeremias, A., Matsuo, H., Kharbanda, R.K., Patel, M.R., Serruys, P., Escaned, J., Davies, J.E., Sen, S., Ahmad, Y., Dehbi, H.M., Howard, J.P., Iglesias, J.F., Al-Lamee, R., Petraco, R., Nijjer, S., Bhindi, R., Lehman, S., Walters, D., Sapontis, J., Janssens, L., Vrints, C.J., Khashaba, A., Laine, M., Belle, E, Krackhardt, F., Bojara, W., Going, O., Harle, T., Indolfi, C., Niccoli, G., Ribichini, F., Tanaka, N., Yokoi, H., Takashima, H., Kikuta, Y., Erglis, A., Vinhas, H., Silva, P.C., Baptista, S.B., Alghamdi, A., Hellig, F., Koo, B.K., Nam, C.W., Shin, E.S., Doh, J.H., Brugaletta, S., Alegria-Barrero, E., Meuwissen, M., Piek, J.J., Royen, N. van, Sezer, M., Mario, C. de, Gerber, R.T., Malik, I.S., Sharp, A.S.P., Talwar, S., Tang, K., Samady, H., Altman, J., Seto, A.H., Singh, J., Jeremias, A., Matsuo, H., Kharbanda, R.K., Patel, M.R., Serruys, P., Escaned, J., and Davies, J.E.
- Abstract
Contains fulltext : 209410.pdf (publisher's version ) (Open Access), BACKGROUND: Physicians are not always comfortable deferring treatment of a stenosis in the left anterior descending (LAD) artery because of the perception that there is a high risk of major adverse cardiac events (MACE). The authors describe, using the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) trial, MACE rates when LAD lesions are deferred, guided by physiological assessment using fractional flow reserve (FFR) or the instantaneous wave-free ratio (iFR). OBJECTIVES: The purpose of this study was to establish the safety of deferring treatment in the LAD using FFR or iFR within the DEFINE-FLAIR trial. METHODS: MACE rates at 1 year were compared between groups (iFR and FFR) in patients whose physiological assessment led to LAD lesions being deferred. MACE was defined as a composite of cardiovascular death, myocardial infarction (MI), and unplanned revascularization at 1 year. Patients, and staff performing follow-up, were blinded to whether the decision was made with FFR or iFR. Outcomes were adjusted for age and sex. RESULTS: A total of 872 patients had lesions deferred in the LAD (421 guided by FFR, 451 guided by iFR). The event rate with iFR was significantly lower than with FFR (2.44% vs. 5.26%; adjusted HR: 0.46; 95% confidence interval [CI]: 0.22 to 0.95; p = 0.04). This was driven by significantly lower unplanned revascularization with iFR and numerically lower MI (unplanned revascularization: 2.22% iFR vs. 4.99% FFR; adjusted HR: 0.44; 95% CI: 0.21 to 0.93; p = 0.03; MI: 0.44% iFR vs. 2.14% FFR; adjusted HR: 0.23; 95% CI: 0.05 to 1.07; p = 0.06). CONCLUSIONS: iFR-guided deferral appears to be safe for patients with LAD lesions. Patients in whom iFR-guided deferral was performed had statistically significantly lower event rates than those with FFR-guided deferral.
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- 2019
36. Clinical relevance of ticagrelor monotherapy following 1-month dual antiplatelet therapy after bifurcation percutaneous coronary intervention: Insight from GLOBAL LEADERS trial
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Kogame, N. (Norihiro), Chichareon, P. (Ply), De Wilder, K. (Kenneth), Takahashi, K. (Kuniaki), Modolo, R. (Rodrigo), Chang, C.C. (Chun Chin), Tomaniak, M. (Mariusz), Komiyama, H. (Hidenori), Chieffo, A. (Alaide), Colombo, A. (Antonio), Garg, S.A. (Scot), Louvard, Y. (Yves), Jüni, P. (Peter), G. Steg, P. (Philippe), Hamm, C. (Christian), Vranckx, P. (Pascal), Valgimigli, M. (Marco), Windecker, S.W. (Stephan), Stoll, H.P., Onuma, Y. (Yoshinobu), Janssens, L. (Luc), Serruys, P.W.J.C. (Patrick), Kogame, N. (Norihiro), Chichareon, P. (Ply), De Wilder, K. (Kenneth), Takahashi, K. (Kuniaki), Modolo, R. (Rodrigo), Chang, C.C. (Chun Chin), Tomaniak, M. (Mariusz), Komiyama, H. (Hidenori), Chieffo, A. (Alaide), Colombo, A. (Antonio), Garg, S.A. (Scot), Louvard, Y. (Yves), Jüni, P. (Peter), G. Steg, P. (Philippe), Hamm, C. (Christian), Vranckx, P. (Pascal), Valgimigli, M. (Marco), Windecker, S.W. (Stephan), Stoll, H.P., Onuma, Y. (Yoshinobu), Janssens, L. (Luc), and Serruys, P.W.J.C. (Patrick)
- Abstract
Background: The aim of this study was to investigate the impact of ticagrelor monotherapy following 1-month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) for bifurcati
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- 2019
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37. Rationale and design of a prospective substudy of clinical endpoint adjudication processes within an investigator-reported randomised controlled trial in patients with coronary artery disease: the GLOBAL LEADERS Adjudication Sub-StudY (GLASSY)
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Leonardi, S., Franzone, A., Piccolo, R., McFadden, E. (Eugene), Vranckx, P. (Pascal), Serruys, P.W.J.C. (Patrick), Benit, E. (Edouard), Liebetrau, C., Janssens, L. (Loes), Ferrario, M, Zurakowski, A., van Geuns, R.J., Dominici, M, Huber, K., Slagboom, T. (Ton), Buszman, P. (Pawel), Bolognese, L, Tumscitz, C. (Carlo), Bryniarski, K., Aminian, A., Vrolix, M.C. (Mathias), Petrov, I. (Ivo), Garg, S.A. (Scot), Naber, C, Prokopczuk, J., Hamm, C.W. (Christian), Steg, G. (G.), Heg, D. (Dik), Juni, P. (Peter), Windecker, S.W. (Stephan), Valgimigli, M. (Marco), Leonardi, S., Franzone, A., Piccolo, R., McFadden, E. (Eugene), Vranckx, P. (Pascal), Serruys, P.W.J.C. (Patrick), Benit, E. (Edouard), Liebetrau, C., Janssens, L. (Loes), Ferrario, M, Zurakowski, A., van Geuns, R.J., Dominici, M, Huber, K., Slagboom, T. (Ton), Buszman, P. (Pawel), Bolognese, L, Tumscitz, C. (Carlo), Bryniarski, K., Aminian, A., Vrolix, M.C. (Mathias), Petrov, I. (Ivo), Garg, S.A. (Scot), Naber, C, Prokopczuk, J., Hamm, C.W. (Christian), Steg, G. (G.), Heg, D. (Dik), Juni, P. (Peter), Windecker, S.W. (Stephan), and Valgimigli, M. (Marco)
- Abstract
pragmatic and superiority randomised controlled trial designed to challenge the current treatment paradigm of dual antiplatelet therapy (DAPT) for 12 months followed by aspirin monotherapy among patients undergoing percutaneous coronary intervention. By design, all study endpoints are investigator reported (IR) and not subject to formal adjudication by an independent Clinical Event Committee (CEC), which may introduce detection, reporting or ascertainment bias. Methods and analysis We designed the GLOBAL LEADERS Adjudication Sub-StudY (GLASSY) to prospectively implement, in a large sample of patients enrolled within the GLOBAL LEADERS trial (7585 of 15 991, 47.5%), an independent adjudication process of reported and unreported potential endpoints, using standardised CEC procedures, in order to assess whether 23-month ticagrelor monotherapy (90mg twice daily) after 1-month DAPT is non-inferior to a standard regimen of DAPT for 12 months followed by aspirin monotherapy for the primary efficacy endpoint of death, nonfatal myocardial infarction, non-fatal stroke or urgent target vessel revascularisation and superior for the primary safety endpoint of type 3 or 5 bleeding according to the Bleeding Academic Research Consortium criteria. This study will comprehensively assess the comparative safety and efficacy of the two tested antithrombotic strategies on CEC-adjudicated ischaemic and bleeding endpoints and will provide insights into the role of a standardised CEC adjudication process on the interpretation of study findings by quantifying the level of concordance between IR-reported and CEC-adjudicated events. Ethics and dissemination GLASSY has been approved by local ethics committee of all study sites and/or by the central ethics committee for the country depending on country-specific regulations. In all cases, they deemed that it was not necess
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- 2019
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38. Clinical relevance of ticagrelor monotherapy following 1-month dual antiplatelet therapy after bifurcation percutaneous coronary intervention: Insight from GLOBAL LEADERS trial
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Kogame, N, Chichareon, P, De Wilder, K, Takahashi, K, Modolo, R, Chang, Chun-Chin, Tomaniak, Mariusz, Komiyama, H, Chieffo, A, Colombo, A, Garg, S, Louvard, Y, Juni, P, Steg, PG, Hamm, C, Vranckx, P, Valgimigli, M, Windecker, S, Stoll, HP, Onuma, Y, Janssens, L, Serruys, PWJC, Kogame, N, Chichareon, P, De Wilder, K, Takahashi, K, Modolo, R, Chang, Chun-Chin, Tomaniak, Mariusz, Komiyama, H, Chieffo, A, Colombo, A, Garg, S, Louvard, Y, Juni, P, Steg, PG, Hamm, C, Vranckx, P, Valgimigli, M, Windecker, S, Stoll, HP, Onuma, Y, Janssens, L, and Serruys, PWJC
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- 2019
39. Rationale and design of a prospective substudy of clinical endpoint adjudication processes within an investigator-reported randomised controlled trial in patients with coronary artery disease: the GLOBAL LEADERS Adjudication Sub-StudY (GLASSY)
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Leonardi, S, Franzone, A, Piccolo, R, McFadden, E, Vranckx, P, Serruys, PWJC, Benit, E, Liebetrau, C, Janssens, L, Ferrario, M, Zurakowski, A, van Geuns, Robert Jan, Dominici, M, Huber, K, Slagboom, T, Buszman, P, Bolognese, L, Tumscitz, C, Bryniarski, K, Aminian, A, Vrolix, M, Petrov, I, Garg, S, Naber, C, Prokopczuk, J, Hamm, C, Steg, G, Heg, D, Juni, P, Windecker, S, Valgimigli, M, Leonardi, S, Franzone, A, Piccolo, R, McFadden, E, Vranckx, P, Serruys, PWJC, Benit, E, Liebetrau, C, Janssens, L, Ferrario, M, Zurakowski, A, van Geuns, Robert Jan, Dominici, M, Huber, K, Slagboom, T, Buszman, P, Bolognese, L, Tumscitz, C, Bryniarski, K, Aminian, A, Vrolix, M, Petrov, I, Garg, S, Naber, C, Prokopczuk, J, Hamm, C, Steg, G, Heg, D, Juni, P, Windecker, S, and Valgimigli, M
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- 2019
40. Transgenerational effects of pesticide on vector mosquito Culex pipiens under global warming
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Tran, T., Janssens, L., and Dinh, Khuong Van
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- 2018
41. Evaluation of colistin stability in agar and comparison of four methods for MIC testing of colistin
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Turlej-Rogacka, A. Xavier, B.B. Janssens, L. Lammens, C. Zarkotou, O. Pournaras, S. Goossens, H. Malhotra-Kumar, S.
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Susceptibility testing for colistin remains challenging primarily due to its inherent properties. We evaluated colistin stability in agar and reproducibility of colistin MICs obtained by agar dilution, broth macro- and micro-dilution and MIC gradient strips on 3–7 iterations of each method using clinical Klebsiella pneumoniae (susceptible-CS, and resistant-CR, n = 2 each), mcr-harboring Escherichia coli (n = 2), and reference strains E. coli ATCC25922 and Pseudomonas aeruginosa ATCC27853. MICs for reference strains were not in the given range using Etest and broth microdilution (ATCC25922, 0.125 and 4 μg/ml, respectively). MICs of CR-1 and CR-2, and of the mcr-harboring E. coli showed high concordance between agar and broth dilution varying up to one 2-fold dilution. However, remarkable variations were observed on broth dilution with CS-1 and CS-2 (MIC range 0.25–32 and 0.5–64 μg/ml, respectively); whereas for agar dilution the MIC for both CS strains was 0.5 μg/ml in all the runs. MICs obtained by MIC gradient strips were lower than those obtained by dilution methods (1–2 dilutions for CS and mcr strains, and up to five dilutions for CR strains). To confirm uniform distribution of colistin in agar, a single strain was spotted in five different regions of the same plate. All spots showed concordant growth with maximum one dilution difference. No effect on MIC was found due to storage of colistin-containing agar plates for 7 days at 4 °C. In our hands, agar dilution was superior in terms of reproducibility and robustness, compared to broth dilution methods, for colistin MIC determination. © 2017, The Author(s).
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- 2018
42. Essentiele V&G eisen voor industriële machines uitgerust met machine learning [Essential H&S requirements for industrial machines equipped with machine learning]
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Steijn, W., Janssens, L., Kwantes, J.H., Beek, D. van der, and Jansen, A.
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Machines ,Work and Employment ,Workplace ,Risico's ,Robots ,Healthy Living - Abstract
De robotindustrie is bezig met een enorme snelheid een opmars te maken in diverse arbeidsdomeinen van zorg tot maakindustrie. In de afgelopen vijftig jaar zijn industriële machines niet alleen sneller en accurater geworden, maar zijn deze machines ook mobieler geworden. Daarnaast hebben deze machines meer bewegingsgraden gekregen, en kunnen deze machines dankzij verbeterde sensoren steeds beter met hun omgeving omgaan. Verder zien we een toenemende digitalisering (waarbinnen de ontwikkelingen parallel lopen aan die van automatisering; Eurofound, 2018), dit houdt in dat (industriële) machines steeds vaker via netwerken aan elkaar en aan het internet worden gekoppeld. Het is belangrijk om bij deze trends vooruit te blijven kijken en de machineveiligheid van morgen te definiëren, zodat een robot al in het ontwerp en de ontwikkeling ervan inherent veilig kan worden gemaakt.
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- 2018
43. Effect of an Inspiratory Muscle Training (IMT) Program on Respiratory Muscle Function, Symptoms of Dyspnea, Respiratory Muscle Activation and Tissue Oxygen Delivery During Exercise Breathing in a Patient with Idiopathic Unilateral Diaphragmatic Paralysis: A Case Report
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Dacha, S., primary, Louvaris, Z., additional, Janssens, L., additional, Testelmans, D., additional, Gosselink, R., additional, and Langer, D., additional
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- 2019
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44. The New Imbroglio. Living with machine algorithms
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Hildebrandt, M., Janssens, L., Janssens, Liisa, Fundamental rights centre, Law Science Technology and Society, Metajuridica, and Janssens, L.
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machine learning ,autonomic ,legal certainty ,Rule of Law ,Digital Security ,public administration ,uncertainty ,dumb algorithms ,automation - Abstract
This essay will discuss two types of algorithms: those capable of learning from their own ‘mistakes’ and those that are not fitted with such capacities. The first concern machine learning (ML), the second can be categorised as ‘dumb’ ‘if this then that’ algorithms (IFTTTs). I will suggest that each can have added value as well as drawbacks, depending on how they are used, in what context and for what purpose. As the decision to engage either one of them may have far-reaching consequences for those subjected to their outcome, I propose that both should be constraint in ways that open them up to scrutiny and render their computational judgements liable to being nullified as a result of legal proceedings.
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- 2016
45. Targeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable polymer coronary stent (TARGET All Comers): a multicentre, open-label, randomised non-inferiority trial
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Lansky, A., Wijns, W., Xu, B., Kelbaek, H., Royen, N. van, Zheng, M., Morel, M.A., Knaapen, P., Slagboom, T., Johnson, T.W., Vlachojannis, G., Arkenbout, K.E., Holmvang, L., Janssens, L., Ochala, A., Brugaletta, S., Naber, C.K., Anderson, R., Rittger, H., Berti, S., Barbato, E., Toth, G.G., Maillard, L., Valina, C., Buszman, P., Thiele, H., Schachinger, V., Baumbach, A., Lansky, A., Wijns, W., Xu, B., Kelbaek, H., Royen, N. van, Zheng, M., Morel, M.A., Knaapen, P., Slagboom, T., Johnson, T.W., Vlachojannis, G., Arkenbout, K.E., Holmvang, L., Janssens, L., Ochala, A., Brugaletta, S., Naber, C.K., Anderson, R., Rittger, H., Berti, S., Barbato, E., Toth, G.G., Maillard, L., Valina, C., Buszman, P., Thiele, H., Schachinger, V., and Baumbach, A.
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Item does not contain fulltext, BACKGROUND: The FIREHAWK is a drug-eluting stent with a fully biodegradable sirolimus-containing polymer coating localised to recessed abluminal grooves on the stent surface. We investigated clinical outcomes with this targeted, low-dose, biodegradable polymer, sirolimus-eluting stent compared with XIENCE durable polymer, everolimus-eluting stents in an all-comers population. METHODS: The TARGET All Comers study was a prospective, multicentre, open-label randomised non-inferiority trial done at 21 centres in ten European countries. Patients with symptomatic or asymptomatic coronary artery disease and objective evidence of myocardial ischaemia who qualified for percutaneous coronary intervention were randomised 1:1 to undergo implantation of a FIREHAWK or XIENCE. Randomisation was web-based, with random block allocation and stratification by centre and ST elevation myocardial infarction. Outcome assessors were masked to treatment allocation, but treating physicians and patients were not. The primary endpoint was target lesion failure at 12 months, a composite of cardiac death, target vessel myocardial infarction, or ischaemia-driven target lesion revascularisation. The control event rate for XIENCE was assumed to be 7%, the non-inferiority margin was 3.5%, and the primary analysis was in the intention-to-treat population, censoring patients who did not have either an event before 365 days or contact beyond 365 days. Late lumen loss was the primary endpoint of an angiographic substudy designed to investigate the non-inferiority of the FIREHAWK compared with the XIENCE stent. This trial is registered with ClinicalTrials.gov, number NCT02520180. FINDINGS: From Dec 17, 2015, to Oct 14, 2016, 1653 patients were randomly assigned to implantation of the FIREHAWK (n=823) or XIENCE (n=830). 65 patients in the FIREHAWK group and 66 in the XIENCE group had insufficient follow-up data and were excluded from the analyses. At 12 months, target lesion failure occurred in 46 (6.1%)
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- 2018
46. Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs aspirin plus clopidogrel or ticagrelor for 12 months, followed by aspirin monotherapy for 12 months after implantation of a drug-eluting stent: a multicentre, open-label, randomised superiority trial
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Vranckx, P., Valgimigli, M., Juni, P., Hamm, C., Steg, P.G., Heg, D., Es, G.A. van, McFadden, E.P., Onuma, Y., Meijeren, C. van, Chichareon, P., Benit, E., Mollmann, H., Janssens, L., Ferrario, M., Moschovitis, A., Zurakowski, A., Dominici, M., Geuns, R.J.M. van, Huber, K., Slagboom, T., Serruys, P.W., Windecker, S., Vranckx, P., Valgimigli, M., Juni, P., Hamm, C., Steg, P.G., Heg, D., Es, G.A. van, McFadden, E.P., Onuma, Y., Meijeren, C. van, Chichareon, P., Benit, E., Mollmann, H., Janssens, L., Ferrario, M., Moschovitis, A., Zurakowski, A., Dominici, M., Geuns, R.J.M. van, Huber, K., Slagboom, T., Serruys, P.W., and Windecker, S.
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Item does not contain fulltext, BACKGROUND: We hypothesised that ticagrelor, in combination with aspirin for 1 month, followed by ticagrelor alone, improves outcomes after percutaneous coronary intervention compared with standard antiplatelet regimens. METHODS: GLOBAL LEADERS was a randomised, open-label superiority trial at 130 sites in 18 countries. Patients undergoing percutaneous coronary intervention with a biolimus A9-eluting stent for stable coronary artery disease or acute coronary syndromes were randomly assigned (1:1) to 75-100 mg aspirin daily plus 90 mg ticagrelor twice daily for 1 month, followed by 23 months of ticagrelor monotherapy, or standard dual antiplatelet therapy with 75-100 mg aspirin daily plus either 75 mg clopidogrel daily (for patients with stable coronary artery disease) or 90 mg ticagrelor twice daily (for patients with acute coronary syndromes) for 12 months, followed by aspirin monotherapy for 12 months. Randomisation was concealed, stratified by centre and clinical presentation (stable coronary artery disease vs acute coronary syndrome), and blocked, with randomly varied block sizes of two and four. The primary endpoint at 2 years was a composite of all-cause mortality or non-fatal centrally adjudicated new Q-wave myocardial infarction as assessed by a core lab in a blinded manner. The key secondary safety endpoint was site-reported bleeding assessed according to the Bleeding Academic Research Consortium criteria (grade 3 or 5). Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT01813435, and is closed to new participants, with follow-up completed. FINDINGS: Between July 1, 2013, and Nov 9, 2015, 15 968 participants were randomly assigned, 7980 to the experimental group and 7988 to the control group. At 2 years, 304 (3.81%) participants in the experimental group had died or had a non-fatal centrally adjudicated new Q-wave myocardial infarction, compared with 349 (4.37%) participants in the control group (rate ratio 0.87
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- 2018
47. BEING PROFILED: COGITAS ERGO SUM 10 YEARS OF ‘PROFILING THE EUROPEAN CITIZEN’
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Bayamlioglu, E., Baraliuc, I., Janssens, L., Hildebrandt, M., Bayamlioglu, E., Baraliuc, I., Janssens, L., and Hildebrandt, M.
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Item does not contain fulltext
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- 2018
48. Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes
- Author
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Escaned, J., Ryan, N., Mejia-Renteria, H., Cook, C.M., Dehbi, H.M., Alegria-Barrero, E., Alghamdi, A., Al-Lamee, R., Altman, J., Ambrosia, A., Baptista, S.B., Bertilsson, M., Bhindi, R., Birgander, M., Bojara, W., Brugaletta, S., Buller, C., Calais, F., Silva, P.C., Carlsson, J., Christiansen, E.H., Danielewicz, M., Mario, C. de, Doh, J.H., Erglis, A., Erlinge, D., Gerber, R.T., Going, O., Gudmundsdottir, I., Harle, T., Hauer, D., Hellig, F., Indolfi, C., Jakobsen, L., Janssens, L., Jensen, J., Jeremias, A., Karegren, A., Karlsson, A.C., Kharbanda, R.K., Khashaba, A., Kikuta, Y., Krackhardt, F., Koo, B.K., Koul, S., Laine, M., Lehman, S.J., Lindroos, P., Malik, I.S., Maeng, M., Matsuo, H., Meuwissen, M., Nam, C.W., Niccoli, G., Nijjer, S.S., Olsson, H., Olsson, S.E., Omerovic, E., Panayi, G., Petraco, R., Piek, J.J., Ribichini, F., Samady, H., Samuels, B., Sandhall, L., Sapontis, J., Sen, S., Seto, A.H., Sezer, M., Sharp, A.S.P., Shin, E.S., Singh, J., Takashima, H., Talwar, S., Tanaka, N., Tang, K., Belle, E. van, Royen, N. van, Varenhorst, C., Vinhas, H., Vrints, C.J., Walters, D., Yokoi, H., Frobert, O., Patel, M.R., Serruys, P., Davies, J.E., Gotberg, M., Escaned, J., Ryan, N., Mejia-Renteria, H., Cook, C.M., Dehbi, H.M., Alegria-Barrero, E., Alghamdi, A., Al-Lamee, R., Altman, J., Ambrosia, A., Baptista, S.B., Bertilsson, M., Bhindi, R., Birgander, M., Bojara, W., Brugaletta, S., Buller, C., Calais, F., Silva, P.C., Carlsson, J., Christiansen, E.H., Danielewicz, M., Mario, C. de, Doh, J.H., Erglis, A., Erlinge, D., Gerber, R.T., Going, O., Gudmundsdottir, I., Harle, T., Hauer, D., Hellig, F., Indolfi, C., Jakobsen, L., Janssens, L., Jensen, J., Jeremias, A., Karegren, A., Karlsson, A.C., Kharbanda, R.K., Khashaba, A., Kikuta, Y., Krackhardt, F., Koo, B.K., Koul, S., Laine, M., Lehman, S.J., Lindroos, P., Malik, I.S., Maeng, M., Matsuo, H., Meuwissen, M., Nam, C.W., Niccoli, G., Nijjer, S.S., Olsson, H., Olsson, S.E., Omerovic, E., Panayi, G., Petraco, R., Piek, J.J., Ribichini, F., Samady, H., Samuels, B., Sandhall, L., Sapontis, J., Sen, S., Seto, A.H., Sezer, M., Sharp, A.S.P., Shin, E.S., Singh, J., Takashima, H., Talwar, S., Tanaka, N., Tang, K., Belle, E. van, Royen, N. van, Varenhorst, C., Vinhas, H., Vrints, C.J., Walters, D., Yokoi, H., Frobert, O., Patel, M.R., Serruys, P., Davies, J.E., and Gotberg, M.
- Abstract
Contains fulltext : 196266.pdf (Publisher’s version ) (Open Access), OBJECTIVES: The aim of this study was to investigate the clinical outcomes of patients deferred from coronary revascularization on the basis of instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute coronary syndromes (ACS). BACKGROUND: Assessment of coronary stenosis severity with pressure guidewires is recommended to determine the need for myocardial revascularization. METHODS: The safety of deferral of coronary revascularization in the pooled per-protocol population (n = 4,486) of the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) and iFR-SWEDEHEART (Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve in Patients With Stable Angina Pectoris or Acute Coronary Syndrome) randomized clinical trials was investigated. Patients were stratified according to revascularization decision making on the basis of iFR or FFR and to clinical presentation (SAP or ACS). The primary endpoint was major adverse cardiac events (MACE), defined as the composite of all-cause death, nonfatal myocardial infarction, or unplanned revascularization at 1 year. RESULTS: Coronary revascularization was deferred in 2,130 patients. Deferral was performed in 1,117 patients (50%) in the iFR group and 1,013 patients (45%) in the FFR group (p < 0.01). At 1 year, the MACE rate in the deferred population was similar between the iFR and FFR groups (4.12% vs. 4.05%; fully adjusted hazard ratio: 1.13; 95% confidence interval: 0.72 to 1.79; p = 0.60). A clinical presentation with ACS was associated with a higher MACE rate compared with SAP in deferred patients (5.91% vs. 3.64% in ACS and SAP, respectively; fully adjusted hazard ratio: 0.61 in favor of SAP; 95% confidence interval: 0.38 to 0.99; p = 0.04). CONCLUSIONS: Overall, deferral of revascularization is equally safe with both iFR and FFR, with a low MACE rate of about 4%. Lesions were more frequently deferred when iFR was used t
- Published
- 2018
49. Effect of supervised implementation of the international classification of functioning, disability and health on physiotherapeutic electronic patient records: A randomized controlled trial
- Author
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Lamsens, L., primary, Peers, K., additional, Janssens, L., additional, Caluwé, K., additional, Kiekens, C., additional, Van Eldere, J., additional, Vandersmissen, J., additional, Vanhaecht, K., additional, and Bruyneel, L., additional
- Published
- 2018
- Full Text
- View/download PDF
50. De Romeinse hondengrafvondsten van Tongeren
- Author
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Janssens, L. A. A., primary
- Published
- 2018
- Full Text
- View/download PDF
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