824 results on '"Janssens, W."'
Search Results
2. Characterization of Small Airway Obstruction Diversity in COPD
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Geudens, V., primary, De Fays, C., additional, Willems, L., additional, Vermaut, A., additional, Aerts, G., additional, Kerckhof, P., additional, Goos, T., additional, Kaes, J., additional, Hooft, C., additional, Jin, X., additional, Beeckmans, H., additional, Khaled Mohamed Elm Mohamady, Y., additional, Aversa, L., additional, Vermant, M., additional, Gyselinck, I., additional, Verhaegen, J., additional, Van Slambrouck, J., additional, Aelbrecht, C., additional, Higham, A., additional, Cortesi, E., additional, Vanstapel, A., additional, McDonough, J.E., additional, Carlon, M.S., additional, Quarck, R., additional, Boone, M., additional, Dupont, L., additional, Weynand, B., additional, Pilette, C., additional, Van Raemdonck, D.E., additional, Ceulemans, L.J., additional, Hogg, J.C., additional, Hackett, T.-L., additional, Vos, R., additional, Wuyts, W.A., additional, Janssens, W., additional, Vanaudenaerde, B., additional, and Gayan-Ramirez, G., additional
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- 2024
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3. Standardisation of Clinical Assessment, Management and Follow-Up of Acute Hospitalised Exacerbation of COPD: A Europe-Wide Consensus
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Ramakrishnan S, Janssens W, Burgel PR, Contoli M, Franssen FME, Greening NJ, Greulich T, Gyselinck I, Halner A, Huerta A, Morgan RL, Quint JK, Vanfleteren LEGW, Vermeersch K, Watz H, and Bafadhel M
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copd ,disease exacerbation ,hospitalisation ,patient care ,consensus development ,expert opinion ,Diseases of the respiratory system ,RC705-779 - Abstract
Sanjay Ramakrishnan,1– 3 Wim Janssens,4 Pierre-Regis Burgel,5 Marco Contoli,6 Frits ME Franssen,7 Neil J Greening,8 Timm Greulich,9 Iwein Gyselinck,4 Andreas Halner,1 Arturo Huerta,10 Rebecca L Morgan,11 Jennifer K Quint,12 Lowie EGW Vanfleteren,13 Kristina Vermeersch,4 Henrik Watz,14 Mona Bafadhel1 1Respiratory Medicine Unit, Nuffield Department of Medicine - Experimental Medicine, University of Oxford, Oxford, UK; 2 National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), University of Oxford, Oxford, UK; 3School of Medical and Health Sciences, Edith Cowan University, Perth, Australia; 4Department of Respiratory Diseases, UZ Leuven, Research Group BREATHE, KU Leuven, Leuven, Belgium; 5Faculty of Medicine, University of Paris and INSERM 1016 Institut Cochin, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris, France; 6Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy; 7Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, Netherlands; 8Department of Respiratory Sciences, NIHR Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital, Leicester, UK; 9Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Centre Giessen and Marburg, Philipps University, Member of the German Centre for Lung Research (DZL), Marburg, Germany; 10Pulmonary and Critical Care Division, Clinica Sagrada Familia, IDIBAPS August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain; 11Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada; 12National Heart & Lung Institute, Imperial College, London, UK; 13COPD Center, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Department of Internal Medicine and Clinical Nutrition at Institute of Medicine, SU Sahlgrenska, Göteborg, Sweden; 14Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, GermanyCorrespondence: Mona BafadhelRespiratory Medicine Unit, Nuffield Department of Medicine Experimental Medicine, University of Oxford, Oxford, UKTel +44 1865 612898Email mona.bafadhel@ndm.ox.ac.ukBackground: Despite hospitalization for exacerbation being a high-risk event for morbidity and mortality, there is little consensus globally regarding the assessment and management of hospitalised exacerbations of COPD. We aimed to establish a consensus list of symptoms, physiological measures, clinical scores, patient questionnaires and investigations to be obtained at time of hospitalised COPD exacerbation and follow-up.Methods: A modified Delphi online survey with pre-defined consensus of importance, feasibility and frequency of measures at hospitalisation and follow-up of a COPD exacerbation was undertaken.Findings: A total of 25 COPD experts from 18 countries contributed to all 3 rounds of the survey. Experts agreed that a detailed history and examination were needed. Experts also agreed on which treatments are needed and how soon these should be delivered. Experts recommended that a full blood count, renal function, C-reactive protein and cardiac blood biomarkers (BNP and troponin) should be measured within 4 hours of admission and that the modified Medical Research Council dyspnoea scale (mMRC) and COPD assessment test (CAT) should be performed at time of exacerbation and follow-up. Experts encouraged COPD clinicians to strongly consider discussing palliative care, if indicated, at time of hospitalisation.Interpretation: This Europe-wide consensus document is the first attempt to standardise the assessment and care of patients hospitalised for COPD exacerbations. This should be regarded as the starting point to build knowledge and evidence on patients hospitalised for COPD exacerbations.Keywords: COPD, disease exacerbation, hospitalisation, patient care, consensus development, expert opinion
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- 2021
4. Direct antivirals working against the novel coronavirus: azithromycin (DAWn-AZITHRO), a randomized, multicenter, open-label, adaptive, proof-of-concept clinical trial of new antivirals working against SARS-CoV-2—azithromycin trial
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Gyselinck, Iwein, Liesenborghs, Laurens, Landeloos, Ewout, Belmans, Ann, Verbeke, Geert, Verhamme, Peter, Vos, Robin, and Janssens, W.
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- 2021
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5. Copper-Heparin Inhalation Therapy To Repair Emphysema: A Scientific Rationale
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Janssen R, Wouters EFM, Janssens W, Daamen WF, Hagedoorn P, de Wit HAJM, Serré J, Gayan-Ramirez G, Franssen FME, Reynaert NL, von der Thüsen JH, and Frijlink HW
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collagen ,copper ,desmosine ,elastin ,emphysema ,fibulin-5 ,heparin ,lysyl oxidase ,lysyl oxidase-like protein 1 ,tropoelastin ,Diseases of the respiratory system ,RC705-779 - Abstract
Rob Janssen,1 Emiel FM Wouters,2 Wim Janssens,3 Willeke F Daamen,4 Paul Hagedoorn,5 Hugo AJM de Wit,6 Jef Serré,3 Ghislaine Gayan-Ramirez,3 Frits ME Franssen,2 Niki L Reynaert,2 Jan H von der Thüsen,7 Henderik W Frijlink5 1Department of Pulmonary Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands; 2Department of Respiratory Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands; 3Laboratory of Respiratory Diseases, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium; 4Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands; 5Department of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, Groningen, University of Groningen, Groningen, The Netherlands; 6Department of Clinical Pharmacy, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands; 7Department of Pathology, Erasmus Medical Center, Rotterdam, The NetherlandsCorrespondence: Rob JanssenDepartment of Pulmonary Medicine, Canisius-Wilhelmina Hospital, Weg Door Jonkerbos 100, Nijmegen, SZ 6532, The NetherlandsEmail rob.janssen@cwz.nlAbstract: Current pharmacotherapy of chronic obstructive pulmonary disease (COPD) aims at reducing respiratory symptoms and exacerbation frequency. Effective therapies to reduce disease progression, however, are still lacking. Furthermore, COPD medications showed less favorable effects in emphysema than in other COPD phenotypes. Elastin fibers are reduced and disrupted, whereas collagen levels are increased in emphysematous lungs. Protease/antiprotease imbalance has historically been regarded as the sole cause of emphysema. However, it is nowadays appreciated that emphysema may also be provoked by perturbations in the sequential repair steps following elastolysis. Essentiality of fibulin-5 and lysyl oxidase-like 1 in the elastin restoration process is discussed, and it is argued that copper deficiency is a plausible reason for failing elastin repair in emphysema patients. Since copper-dependent lysyl oxidases crosslink elastin as well as collagen fibers, copper supplementation stimulates accumulation of both proteins in the extracellular matrix. Restoration of abnormal elastin fibers in emphysematous lungs is favorable, whereas stimulating pulmonary fibrosis formation by further increasing collagen concentrations and organization is detrimental. Heparin inhibits collagen crosslinking while stimulating elastin repair and might therefore be the ideal companion of copper for emphysema patients. Efficacy and safety considerations may lead to a preference of pulmonary administration of copper-heparin over systemic administration.Keywords: collagen, copper, desmosine, elastin, emphysema, fibulin-5, heparin, lysyl oxidase, lysyl oxidase-like protein 1, tropoelastin
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- 2019
6. Area under the forced expiratory flow-volume loop in spirometry indicates severe hyperinflation in COPD patients
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Das N, Topalovic M, Aerts JM, and Janssens W
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Spirometry ,flow-volume loop ,air-trapping ,severe hyperinflation ,chronic obstructive pulmonary disease ,Diseases of the respiratory system ,RC705-779 - Abstract
Nilakash Das,1 Marko Topalovic,1 Jean-Marie Aerts,2 Wim Janssens1 1Laboratory of Respiratory Diseases, Department of Chronic Diseases, Metabolism and Ageing, Katholieke Universiteit Leuven, Leuven, Belgium; 2Division of Animal and Human Health Engineering, Department of Biosystems, Katholieke Universiteit Leuven, Leuven, Belgium Background: Severe hyperinflation causes detrimental effects such as dyspnea and reduced exercise capacity and is an independent predictor of mortality in COPD patients. Static lung volumes are required to diagnose severe hyperinflation, which are not always accessible in primary care. Several studies have shown that the area under the forced expiratory flow-volume loop (AreaFE) is highly sensitive to bronchodilator response and is correlated with residual volume/total lung capacity (RV/TLC), a common index of air trapping. In this study, we investigate the role of AreaFE% (AreaFE expressed as a percentage of reference value) and conventional spirometry parameters in indicating severe hyperinflation. Materials and methods: We used a cohort of 215 individuals with COPD. The presence of severe hyperinflation was defined as elevated air trapping (RV/TLC >60%) or reduced inspiratory fraction (inspiratory capacity [IC]/TLC 60% and IC/TLC
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- 2019
7. COPD
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Troosters, T., Barbier, V., Janssens, W., Cambier, D., editor, Hobbelen, J. S. M., editor, and de Vries, N. M., editor
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- 2017
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8. The likelihood of improving physical activity after pulmonary rehabilitation is increased in patients with COPD who have better exercise tolerance
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Osadnik CR, Loeckx M, Louvaris Z, Demeyer H, Langer D, Rodrigues FM, Janssens W, Vogiatzis I, and Troosters T
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Exercise and Pulmonary Rehabilitation ,COPD ,Physical activity ,Clinical Respiratory Medicine ,Diseases of the respiratory system ,RC705-779 - Abstract
Christian R Osadnik,1–4,* Matthias Loeckx,1,5,6,* Zafeiris Louvaris,1,7 Heleen Demeyer,1,6 Daniel Langer,1,6 Fernanda M Rodrigues,1,6 Wim Janssens,6,8 Ioannis Vogiatzis,7,9 Thierry Troosters1,6 1Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium; 2Department of Physiotherapy, Monash University, Melbourne, Victoria, Australia; 3Monash Lung and Sleep, Monash Health, Melbourne, Victoria, Australia; 4Institute for Breathing and Sleep, Melbourne, Victoria, Australia; 5Department of Physiotherapy, LUNEX International University of Health, Exercise and Sports, Differdange, Luxembourg; 6Respiratory Division, University Hospitals, KU Leuven, Leuven, Belgium; 7Faculty of Physical Education and Sports Sciences, National and Kapodistrian University of Athens, Athens, Greece; 8Department of Chronic Disease, Metabolism and Aging, KU Leuven, Leuven, Belgium; 9Department of Sport, Exercise and Rehabilitation, Northumbria University Newcastle, Newcastle upon Tyne, UK *These authors contributed equally to this work Purpose: Pulmonary rehabilitation (PR) enhances exercise tolerance in patients with COPD; however, improvements in physical activity (PA) are not guaranteed. This study explored the relationship between baseline exercise tolerance and changes in PA after PR.Materials and methods: Patient data from prospective clinical trials in the PR settings of Athens and Leuven (2008–2016) were analyzed. Validated PA monitors were worn for 1 week before and after a 12-week program. The proportion of patients who improved PA levels ≥1,000 steps/day (“PA responders”) after PR was compared between those with initial 6-minute walk distance [6MWDi]
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- 2018
9. Overuse of inhaled corticosteroids in COPD: five questions for withdrawal in daily practice
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Cataldo D, Derom E, Liistro G, Marchand E, Ninane V, Peché R, Slabbynck H, Vincken W, and Janssens W
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COPD ,exacerbation ,withdrawal ,inhaled steroids ,systematic review ,education ,Diseases of the respiratory system ,RC705-779 - Abstract
Didier Cataldo,1 Eric Derom,2 Giuseppe Liistro,3 Eric Marchand,4,5 Vincent Ninane,6 Rudi Peché7 Hans Slabbynck,8 Walter Vincken,9 Wim Janssens10 1Department of Respiratory Medicine, Centre Hospitalier Universitaire de Liège (CHU) and University of Liège, Liège, Belgium; 2Department of Respiratory Medicine, Ghent University Hospital, Gent, Belgium; 3Department of Respiratory Medicine, University Hospitals Saint-Luc, Brussels, Belgium; 4Department of Respiratory Medicine, University Hospital UCL Namur, Yvoir, Belgium; 5URPhyM, University of Namur, Namur, Belgium; 6Department of Respiratory Medicine, University Hospital Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium; 7Department of Respiratory Medicine, University Hospital Vésale, Montigny-le-Tilleul, Belgium; 8Department of Respiratory Medicine, ZNA Middelheim, Antwerpen, Belgium; 9Respiratory Division, University Hospital Brussels (UZ Brussel), Vrije Universiteit Brussel, Brussels, Belgium; 10Department of Respiratory Medicine, University Hospitals Leuven, Leuven, Belgium Abstract: Evidence and guidelines are becoming increasingly clear about imbalance between the risks and benefits of inhaled corticosteroids (ICSs) in patients with COPD. While selected patients may benefit from ICS-containing regimens, ICSs are often inappropriately prescribed with – according to Belgian market research data – up to 70% of patients in current practice receiving ICSs, usually as a fixed combination with a long-acting β2-adrenoreceptor agonist. Studies and recommendations support withdrawal of ICSs in a large group of patients with COPD. However, historical habits appear difficult to change even in the light of recent scientific evidence. We have built a collaborative educational platform with chest physicians and primary care physicians to increase awareness and provide guidance and support in this matter. Keywords: COPD, exacerbation, withdrawal, inhaled steroids, systematic review, education
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- 2018
10. Significance of prolonged QTc in acute exacerbations of COPD requiring hospitalization
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Van Oekelen O, Vermeersch K, Everaerts S, Vandenberk B, Willems R, and Janssens W
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COPD — acute exacerbation — cardiovascular morbidity — prolonged QT interval — ECG ,Diseases of the respiratory system ,RC705-779 - Abstract
Oliver Van Oekelen,1,* Kristina Vermeersch,1,2,* Stephanie Everaerts,1,2 Bert Vandenberk,3,4 Rik Willems,3,4 Wim Janssens1,2 1Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium; 2Department of Chronic Diseases, Metabolism and Ageing, Laboratory of Respiratory Diseases, KU Leuven, Leuven, Belgium; 3Department of Cardiology, University Hospitals Leuven, Leuven, Belgium; 4Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium *These authors contributed equally to this work Background: A prolonged QT interval is associated with increased risk of Torsade de Pointes and cardiovascular death. The prevalence and clinical relevance of QT prolongation in acute exacerbations of COPD (AECOPD), with high risk for cardiac morbidity and mortality, is currently unclear. Methods: A dual cross-sectional study strategy was therefore designed. A retrospective study evaluated 140 patients with an AECOPD requiring hospitalization, half of which had prolonged QTc on the admission ECG. Univariate and multivariate analyses were conducted to determine associated factors; Kaplan–Meier and Cox regression analyses to assess prognostic significance. A prospective study evaluated 180 pulmonary patients with acute respiratory problems requiring hospitalization, to determine whether a prolonged QTc at admission represents an AECOPD-specific finding and to investigate the change in QTc-duration during hospitalization. Results: Retrospectively, hypokalemia, cardiac troponin T and conductance abnormalities on ECG were significantly and independently associated with QTc prolongation. A prolonged QTc was associated with increased all-cause mortality (HR 2.698 (95% CI 1.032–7.055), p=0.043), however, this association was no longer significant when corrected for age, FEV1 and cardiac troponin T. Prospectively, QTc prolongation was observed in 1/3 of the patients diagnosed with either an AECOPD, lung cancer, pulmonary infection or miscellaneous acute pulmonary disease, and was not more prevalent in AECOPD. The QTc-duration decreased significantly during hospitalization in patients with and without COPD. Conclusion: A prolonged QTc is a marker of underlying cardiovascular disease during an AECOPD. It is not COPD-specific, but a common finding during the acute phase of a pulmonary disease requiring urgent hospital admission. Keywords: COPD, acute exacerbation, cardiovascular morbidity, prolonged QT interval, ECG, Bazett
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- 2018
11. Overview of the Cooperative Projects Implemented by the European Commission Joint Research Centre in the Nuclear Security Area Outside Europe
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Peerani, Paolo, Berthou, V., Janssens, W., Mayer, K., Apikyan, Samuel, editor, and Diamond, David, editor
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- 2015
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12. Sensitization to Aspergillus fumigatus as a risk factor for bronchiectasis in COPD
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Everaerts S, Lagrou K, Dubbeldam A, Lorent N, Vermeersch K, Van Hoeyveld E, Bossuyt X, Dupont LJ, Vanaudenaerde BM, and Janssens W
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COPD ,bronchiectasis ,Aspergillus fumigatus hypersensitivity ,sensitization ,recombinant antigens ,Diseases of the respiratory system ,RC705-779 - Abstract
Stephanie Everaerts,1,2 Katrien Lagrou,3,4 Adriana Dubbeldam,5 Natalie Lorent,1 Kristina Vermeersch,2 Erna Van Hoeyveld,3 Xavier Bossuyt,3,4 Lieven J Dupont,1,2 Bart M Vanaudenaerde,2 Wim Janssens1,2 1Department of Respiratory Diseases, University Hospitals Leuven, 2Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KU Leuven, 3Department of Laboratory Medicine, University Hospitals Leuven, 4Department of Microbiology and Immunology, KU Leuven, 5Department of Radiology, University Hospitals Leuven, Leuven, Belgium Background: Bronchiectasis–chronic obstructive pulmonary disease (COPD) overlap presents a possible clinical phenotype of COPD, but it is unclear why it develops in a subset of patients. We hypothesized that sensitization to Aspergillus fumigatus (A fum) is associated with bronchiectasis in COPD and occurs more frequently in vitamin D-deficient patients.Methods: This observational study investigated sensitization to A fum in an outpatient clinical cohort of 300 COPD patients and 50 (ex-) smoking controls. Total IgE, A fum-specific IgE against the crude extract and against the recombinant antigens and A fum IgG were measured using ImmunoCAP fluoroenzyme immunoassay. Vitamin D was measured by radioimmunoassay, and computed tomography images of the lungs were scored using the modified Reiff score.Results: Sensitization to A fum occurred in 18% of COPD patients compared to 4% of controls (P=0.0110). In all, 31 COPD patients (10%) were sensitized to the crude extract and 24 patients (8%) had only IgE against recombinant antigens. A fum IgG levels were significantly higher in the COPD group (P=0.0473). Within COPD, A fum-sensitized patients were more often male (P=0.0293) and more often had bronchiectasis (P=0.0297). Pseudomonas aeruginosa and Serratia marcescens were more prevalent in historical sputum samples of A fum-sensitized COPD patients compared to A fum-non-sensitized COPD patients (P=0.0436). Vitamin D levels were comparable (P=0.2057). Multivariate analysis demonstrated that sensitization to recombinant f1 or f3 had a 2.8-fold increased risk for bronchiectasis (P=0.0030).Conclusion: These results highlight a potential role for sensitization to A fum in COPD-related bronchiectasis. Keywords: Aspergillus fumigatus hypersensitivity, recombinant antigens, ABPA, vitamin D
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- 2017
13. Inhaled treatment of COPD: a Delphi consensus statement
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Ninane V, Corhay JL, Germonpré P, Janssens W, Joos GF, Liistro G, Vincken W, Gurdain S, Vanvlasselaer E, and Lehouck A
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COPD ,inhalation therapy ,delphi ,guidelines ,Diseases of the respiratory system ,RC705-779 - Abstract
Vincent Ninane,1 Jean-Louis Corhay,2 Paul Germonpré,3 Wim Janssens,4 Guy F Joos,5 Giuseppe Liistro,6 Walter Vincken,7 Sandra Gurdain,8 Evelyne Vanvlasselaer,8 An Lehouck8 1Department of Respiratory Medicine, Saint-Pierre Hospital, Université Libre de Bruxelles, Brussels, 2Department of Respiratory Medicine, CHU, Liege, 3Department of Respiratory Medicine, AZ Maria Middelares, Ghent, 4Department of Respiratory Medicine, Katholieke Universiteit, Leuven, 5Department of Respiratory Medicine, Ghent University Hospital, Ghent, 6Department of Respiratory Medicine, University Hospitals Saint-Luc, Brussels, 7Department of Respiratory Medicine, University Hospital Brussels, Brussels, 8Medical Department, Novartis Pharma, Vilvoorde, Belgium Background: Global Initiative for Chronic Obstructive Lung Disease (GOLD) global strategy (2015) provides guidance for the treatment of chronic obstructive pulmonary disease (COPD) with different first-choice options per GOLD category without specification. Objectives: To evaluate the level of medical experts’ consensus on their preferred first-choice treatment within different COPD categories. Methods: A two-round Delphi Panel consisting of 15 questions was completed by Belgian pulmonologists (n=31) and European (n=10) COPD experts. Results: Good consensus was reached by both expert groups for long-acting bronchodilators instead of short-acting bronchodilators as first-choice treatment in GOLD A. Single bronchodilation with long-acting muscarinic antagonist (LAMA) was preferred over long-acting ß2-agonist (LABA) and LABA/LAMA as first-choice treatment in GOLD B and GOLD C. For GOLD D patients based on the forced expiratory volume in 1 second (FEV1)
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- 2017
14. A Belgian survey on the diagnosis of asthma–COPD overlap syndrome
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Cataldo D, Corhay JL, Derom E, Louis R, Marchand E, Michils A, Ninane V, Peché R, Pilette C, Vincken W, and Janssens W
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ACOS ,airway obstruction ,asthma ,COPD ,diagnosis ,inhaled corticosteroids. ,Diseases of the respiratory system ,RC705-779 - Abstract
Didier Cataldo,1 Jean-Louis Corhay,1 Eric Derom,2 Renaud Louis,1 Eric Marchand,3,4 Alain Michils,5 Vincent Ninane,6 Rudi Peché,7 Charles Pilette,8 Walter Vincken,9 Wim Janssens10 1Department of Respiratory Diseases, CHU Liège, University of Liège, Liège, 2Department of Respiratory Medicine, Ghent University Hospital, Ghent, 3Department of Respiratory Medicine, CHU – UCL – Namur, Université catholique de Louvain, Yvoir, 4Molecular Physiology Research Unit (URPhyM)-NARILIS, Laboratory of General Physiology, University of Namur, Namur, 5Chest Department, Erasme University Hospital, Université Libre de Bruxelles, Brussels, 6Department of Respiratory Medicine, University Hospital Saint-Pierre, Université Libre de Bruxelles, Brussels, 7Department of Respiratory Medicine, University Hospital Vésale, Montigny-le-Tilleul, 8Department of Respiratory Medicine, Cliniques universitaires St Luc, Université Catholique de Louvain, Brussels, 9Respiratory Division, University Hospital Brussels (UZ Brussel), Vrije Universiteit Brussel, Brussels, 10Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium Introduction: Patients with chronic airway disease may present features of both asthma and COPD, commonly referred to as asthma–COPD overlap syndrome (ACOS). Recommendations on their diagnosis are diffuse and inconsistent. This survey aimed to identify consensus on criteria for diagnosing ACOS.Methods: A Belgian expert panel developed a survey on ACOS diagnosis, which was completed by 87 pulmonologists. Answers chosen by ≥70% of survey respondents were considered as useful criteria for ACOS diagnosis. The two most frequently selected answers were considered as major criteria, others as minor criteria. The expert panel proposed a minimal requirement of two major criteria and one minor criterion for ACOS diagnosis. Respondents were also asked which criteria are important for considering inhaled corticosteroids prescription in a COPD patient.Results: To diagnose ACOS in COPD patients, major criteria were “high degree of variability in airway obstruction over time (change in forced expiratory volume in 1 second ≥400 mL)” and “high degree of response to bronchodilators (>200 mL and ≥12% predicted above baseline)”. Minor criteria were “personal/family history of atopy and/or IgE sensitivity to ≥1 airborne allergen”, “elevated blood/sputum eosinophil levels and/or increased fractional exhaled nitric oxide”, “diagnosis of asthma 40 years”; “emphysema on chest computed tomography scan”.Conclusion: Specific criteria were identified that may guide physicians to a more uniform diagnostic approach for ACOS in COPD or asthma patients. These criteria are largely similar to those used to prescribe inhaled corticosteroids in COPD. Keywords: ACOS, airway obstruction, asthma, COPD, diagnosis, inhaled corticosteroids
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- 2017
15. Identifying Responder Subgroups for Exacerbations Using Machine Learning in the Impact Trial
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Verstraete, K., primary, Gyselinck, I., additional, Huts, H., additional, Staes, M., additional, De Vos, M., additional, and Janssens, W., additional
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- 2023
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16. Impact of the ERS/ATS 2021 Guidelines for Lung Function Interpretation
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Topalovic, M., primary, Desbordes, P., additional, Maes, J., additional, de Jong, F., additional, Sylvester, K., additional, Vogelmeier, C.F., additional, Dinh-Xuan, A.T., additional, Mortensen, J., additional, and Janssens, W., additional
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- 2023
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17. Morphometric Airway Changes in Explanted Human Lungs with Chronic Lung Allograft Dysfunction
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Kerckhof, P., primary, Ambrosio, G.P., additional, Beeckmans, H., additional, Kaes, J., additional, Geudens, V., additional, Slambrouck, J., additional, Bos, S., additional, Vermant, M., additional, Aelbrecht, C., additional, Lynn, W., additional, Astrid, V., additional, Aversa, L., additional, Mohamady, Y., additional, Jin, X., additional, Charlotte, D., additional, Goos, T., additional, Iwein, G., additional, Vanstapel, A., additional, Orlitova, M., additional, Boone, M., additional, Janssens, W., additional, Josipovic, I., additional, Varghese, V., additional, Dupont, L., additional, Godinas, L., additional, Verleden, G., additional, Van Raemdonck, D., additional, Ceulemans, L., additional, Neyrinck, A., additional, McDonough, J., additional, Gayan-Ramirez, G., additional, Vanaudenaerde, B., additional, and Vos, R., additional
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- 2023
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18. Early integrated palliative care in chronic heart failure and chronic obstructive pulmonary disease: protocol of a feasibility before-after intervention study
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Siouta, N., Heylen, A., Aertgeerts, B., Clement, P., Van Cleemput, J., Janssens, W., and Menten, J.
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- 2019
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19. Survival after pulmonary rehabilitation in patients with COPD: impact of functional exercise capacity and its changes
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Camillo CA, Langer D, Osadnik CR, Pancini L, Demeyer H, Burtin C, Gosselink R, Decramer M, Janssens W, and Troosters T
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Pulmonary Disease ,Chronic Obstructive ,pulmonary rehabilitation ,Exercise ,Mortality ,Minimally Important Difference. ,Diseases of the respiratory system ,RC705-779 - Abstract
Carlos A Camillo,1,2 Daniel Langer,1,2 Christian R Osadnik,1,3–5 Lisa Pancini,2 Heleen Demeyer,1,2 Chris Burtin,1,6 Rik Gosselink,1,2 Marc Decramer,2 Wim Janssens,2 Thierry Troosters1,2 1KU Leuven, Department of Rehabilitation Sciences, Leuven, Belgium; 2University Hospital Leuven, Respiratory Division and Rehabilitation, Leuven, Belgium; 3Monash University, Department of Physiotherapy, Melbourne, VIC, Australia; 4Institute for Breathing and Sleep, Melbourne, VIC, Australia; 5Monash Health, Monash Lung and Sleep, Melbourne, VIC, Australia; 6Hasselt University, Rehabilitation Research Centre, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Diepenbeek, Belgium Abstract: The impact of rehabilitation-induced changes in 6-minute walk distance (6MWD) on the survival of patients with chronic obstructive pulmonary disease (COPD) has not been fully elucidated. This study sought to determine the association of baseline 6MWD and its changes after pulmonary rehabilitation (PR) with 5-year survival in patients with COPD. Patients who were referred to a 12-week outpatient PR program were followed up for 5 years postcompletion, and survival status was verified. Survival was analyzed according to four groups based upon initial 6MWD (6MWDi) and its changes (Δ6MWD) after PR (Group 1: 6MWDi ≥350 m and Δ6MWD ≥30 m; Group 2: 6MWDi ≥350 m and Δ6MWD 30 m after PR are associated with worse 5-year survival in patients with COPD. Keywords: pulmonary disease, chronic obstructive, exercise training, mortality, 6-minute walk test, minimally important difference
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- 2016
20. The Belgian trial with azithromycin for acute COPD exacerbations requiring hospitalization: an investigator-initiated study protocol for a multicenter, randomized, double-blind, placebo-controlled trial
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Vermeersch K, Gabrovska M, Deslypere G, Demedts IK, Slabbynck H, Aumann J, Ninane V, Verleden GM, Troosters T, Bogaerts K, Brusselle GG, and Janssens W
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COPD ,Acute exacerbation ,Macrolide antibiotics ,Azithromycin ,Physical activity ,Diseases of the respiratory system ,RC705-779 - Abstract
Kristina Vermeersch,1 Maria Gabrovska,2 Griet Deslypere,3 Ingel K Demedts,4 Hans Slabbynck,5 Joseph Aumann,3 Vincent Ninane,2 Geert M Verleden,1 Thierry Troosters,1,6 Kris Bogaerts,7,8 Guy G Brusselle,9 Wim Janssens1 On behalf of the BACE Trial Investigators 1KU Leuven, Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, Faculty of Medicine, Leuven, Belgium; 2Department of Pneumology, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium; 3Department of Pneumology, Jessa Ziekenhuis, Hasselt, Belgium; 4Department of Respiratory Medicine, AZ Delta Roeselare-Menen, Roeselare, Belgium; 5Department of Respiratory Medicine, ZNA Middelheim, Antwerpen, Belgium; 6KU Leuven, Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, Leuven, Belgium; 7KU Leuven, Department of Public Health and Primary Care, I-BioStat, Leuven, Belgium; 8Hasselt University, Hasselt, Belgium; 9Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium Background: Long-term use of macrolide antibiotics is effective to prevent exacerbations in chronic obstructive pulmonary disease (COPD). As risks and side effects of long-term intervention outweigh the benefits in the general COPD population, the optimal dose, duration of treatment, and target population are yet to be defined. Hospitalization for an acute exacerbation (AE) of COPD may offer a targeted risk group and an obvious risk period for studying macrolide interventions.Methods/design: Patients with COPD, hospitalized for an AE, who have a smoking history of ≥10 pack-years and had ≥1 exacerbation in the previous year will be enrolled in a multicenter, randomized, double-blind, placebo-controlled trial (NCT02135354). On top of a standardized treatment of systemic corticosteroids and antibiotics, subjects will be randomized to receive either azithromycin or placebo during 3 months, at an uploading dose of 500 mg once a day for 3 days, followed by a maintenance dose of 250 mg once every 2 days. The primary endpoint is the time-to-treatment failure during the treatment phase (ie, from the moment of randomization until the end of intervention). Treatment failure is a novel composite endpoint defined as either death, the admission to intensive care or the requirement of additional systemic steroids or new antibiotics for respiratory reasons, or the diagnosis of a new AE after discharge.Discussion: We investigate whether azithromycin initiated at the onset of a severe exacerbation, with a limited duration and at a low dose, might be effective and safe in the highest risk period during and immediately after the acute event. If proven effective and safe, this targeted approach may improve the treatment of severe AEs and redirect the preventive use of azithromycin in COPD to a temporary intervention in the subgroup with the highest unmet needs. Keywords: COPD, acute exacerbation, macrolide antibiotics, azithromycin, physical activity, RCT
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- 2016
21. Machine learning-based individual treatment effect estimation of azithromycin on COPD exacerbations
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Verstraete, K, primary, Gyselinck, I, additional, Staes, M, additional, Lindberg, S, additional, Albert, R, additional, Connett, J, additional, De Vos, M, additional, and Janssens, W, additional
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- 2022
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22. Impact of the ERS/ATS 2021 guidelines for lung function interpretation
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Topalovic, M, primary, Desbordes, P, additional, Maes, J, additional, Sylvester, K, additional, De Jongh, F, additional, Janssens, W, additional, and Topalovic, M, additional
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- 2022
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23. Hybrid pulmonary rehabilitation versus conventional outpatient pulmonary rehabilitation: a propensity-matched analysis
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Wuyts, M, primary, Blondeel, A, additional, Breuls, S, additional, Vanhoutte, T, additional, Barbier, V, additional, Beersaerts, A, additional, Claes, L, additional, Coosemans, I, additional, Vandenbergh, N, additional, Demeyer, H, additional, Troosters, T, additional, Janssens, W, additional, and On Behalf Of Leuven Pulmonary Rehabilitation, ., additional
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- 2022
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24. Early detection of interstitial lung disease using AI-powered spirometry
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TOPALOVIC, M, primary, Coenegrachts, T, additional, Van Steenbergen, S, additional, Halilovic, A, additional, Maes, J, additional, De Sadeleer, L, additional, and Janssens, W, additional
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- 2022
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25. Improved peak exercise performance after 12 weeks of pulmonary rehabilitation in patients post COVID-19
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Troosters, T, primary, Everaert, S, additional, Coosemans, I, additional, Claes, L, additional, Demeyer, H, additional, Vanhoutte, T, additional, Glorie, L, additional, Lorent, N, additional, and Janssens, W, additional
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- 2022
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26. JAK-STAT pathway is upregulated in CLAD
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Beeckmans, H, primary, Mcdonough, J E, additional, De Sadeleer, L, additional, Sacreas, A, additional, Vanstapel, A, additional, Kaes, J, additional, Van Herck, A, additional, Maes, K, additional, Gayan-Ramirez, G, additional, Janssens, W, additional, Schoemans, H, additional, Wauters, E, additional, Neyrinck, A P, additional, Verleden, G M, additional, Dupont, L J, additional, Laurent, G, additional, Ceulemans, L J, additional, Van Raemdonck, D E, additional, Vanaudenaerde, B M, additional, and Vos, R, additional
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- 2022
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27. Neural processing of respiratory sensations during resistive load-induced dyspnea in patients with COPD
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Vanden Bossche, L, primary, Denutte, Y, additional, Reijnders, T, additional, Davenport, P W, additional, Janssens, W, additional, Troosters, T, additional, and Von Leupoldt, A, additional
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- 2022
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28. Comparing CT-based fissure completeness scores across software packages to predict interlobar collateral ventilation
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Gyselinck, I, primary, Hoeben, P, additional, Geysen, H, additional, De Keyzer, F, additional, Dooms, C, additional, Van Raemdonck, D, additional, Verleden, G, additional, Ceulemans, L, additional, Janssens, W, additional, and Coolen, J, additional
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- 2022
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29. Principal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD
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Verstraete, K, primary, Das, N, additional, Gyselinck, I, additional, Topalovic, M, additional, Troosters, T, additional, De Vos, M, additional, and Janssens, W, additional
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- 2022
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30. Terminal bronchioles decrease before emphysematous destruction and adaptive immune response in human explant lungs with COPD
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de Fays, C, primary, Beeckmans, H, additional, Kerckhof, P, additional, Geudens, V, additional, Vermaut, A, additional, Gyselinck, I, additional, Goos, T, additional, Vermant, M, additional, Kaes, J, additional, Aelbrecht, C, additional, Maes, K, additional, Mohamady, Y, additional, Aversa, L, additional, Everaerts, S, additional, Mcdonough, J E, additional, De Sadeleer, L J, additional, Gohy, S, additional, Ambroise, J, additional, Wuyts, W A, additional, Janssens, W, additional, Ceulemans, L J, additional, Van Raemdonck, D E, additional, Vos, R, additional, Kaminski, N, additional, Pilette, C, additional, Gayan-Ramirez, G, additional, and Vanaudenaerde, B M, additional
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- 2022
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31. Airway remodeling in COVID-19 lungs
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Geudens, V, primary, Van Slambrouck, J, additional, Aerts, G, additional, Willems, L, additional, Goos, T, additional, Kaes, J, additional, Gyselinck, I, additional, Aelbrecht, C, additional, Vermaut, A, additional, Beeckmans, H, additional, Vermant, M, additional, De Fays, C, additional, Sacreas, A, additional, Aversa, L, additional, Verstraete, K, additional, Orlitová, M, additional, Vanstapel, A, additional, E. Mcdonough, J, additional, Pilette, C, additional, Janssens, W, additional, A. Wuyts, W, additional, M. Verleden, G, additional, E. Van Raemdonck, D, additional, Vos, R, additional, Gayan-Ramirez, G, additional, J. Ceulemans, L, additional, and M. Vanaudenaerde, B, additional
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- 2022
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32. Pulmonologists collaborate with explainable artificial intelligence for superior interpretation of pulmonary function tests
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Das, N, primary, Happaerts, S, additional, Dinh-Xuan, A T, additional, Vanderelst, E, additional, Haenebalcke, C, additional, Brusselle, G, additional, Derom, E, additional, Burgos, F, additional, Franssen, F, additional, Watz, H, additional, Quint, J, additional, Moises, J, additional, Contoli, M, additional, Steiner, M, additional, Greening, N, additional, Peché, R, additional, Gonem, S, additional, Poberezhets, V, additional, Mann, W, additional, Topalovic, M, additional, and Janssens, W, additional
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- 2022
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33. Physical activity coaching in patients with ILD: a pilot study
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Breuls, S, primary, Blondeel, A, additional, Wuyts, M, additional, Yserbyt, J, additional, Janssens, W, additional, Wuyts, W, additional, Demeyer, H, additional, and Troosters, T, additional
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- 2022
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34. External validation of machine learning prediction model for pulmonary hypertension due to left heart disease
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Verstraete, K, primary, Swinnen, K, additional, Baratto, C, additional, De Vos, M, additional, Topalovic, M, additional, Claessen, G, additional, Quarck, R, additional, Belge, C, additional, Vachiery, J, additional, Janssens, W, additional, and Delcroix, M, additional
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- 2022
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35. PROM and PREM preferences in COPD-patients
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Gyselinck, I, primary, Vermeersch, K, additional, Pott, H, additional, Ramakrishnan, S, additional, Halner, A, additional, Collis, P, additional, Coleman, C, additional, Watz, H, additional, Dobbels, F, additional, Franssen, F, additional, Greulich, T, additional, Burgel, P, additional, Bafadhel, M, additional, and Janssens, W, additional
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- 2022
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36. Comparable neural gating of respiratory sensations during increasing dyspnea across different qualities of dyspnea
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Denutte, Y, primary, Holk, T, additional, Janssens, W, additional, Troosters, T, additional, and Von Leupoldt, A, additional
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- 2022
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37. Timing of inspiratory muscle activity in patients with unilateral diaphragm dysfunction
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Rodrigues, A, primary, Janssens, L, additional, Dacha, S, additional, Louvaris, Z, additional, Gojevic, T, additional, Janssens, W, additional, Brochard, L, additional, Gosselink, R, additional, Reid, W D, additional, and Langer, D, additional
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- 2022
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38. An in depth study of morphological small airway changes in explant lungs with end stage COPD
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de Fays, C, primary, Geudens, V, additional, Beeckmans, H, additional, Vermaut, A, additional, Gyselinck, I, additional, Goos, T, additional, Vermant, M, additional, Kaes, J, additional, Aelbrecht, C, additional, Maes, K, additional, Mohamady, Y, additional, Willems, L, additional, Aversa, L, additional, Everaerts, S, additional, Mcdonough, J E, additional, De Sadeleer, L, additional, Gohy, S, additional, Wuyts, W A, additional, Janssens, W, additional, Ceulemans, L J, additional, Van Raemdonck, D E, additional, Vos, R, additional, Pilette, C, additional, Gayan-Ramirez, G, additional, and Vanaudenaerde, B M, additional
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- 2022
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39. Correlates of physical activity in patients with COPD: a multifactorial approach
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Blondeel, A, primary, Demeyer, H, additional, Breuls, S, additional, Wuyts, M, additional, Hermans, F, additional, De Maeyer, N, additional, Derom, E, additional, Janssens, W, additional, and Troosters, T, additional
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- 2022
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40. Endoscopic advanced imaging of the respiratory tract: exploring probe-based confocal laser endomicroscopy in emphysema
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Yserbyt, J, Dooms, C, Janssens, W, and Verleden, G M
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- 2018
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41. Quality and reproducibility of spirometry in COPD patients in a randomized trial (UPLIFT®)
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Janssens, W., Liu, Y., Liu, D., Kesten, S., Tashkin, D.P., Celli, B.R., and Decramer, M.
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- 2013
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42. SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study
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Nepogodiev, D., Simoes, J. F. F., Li, E., Picciochi, M., Glasbey, J. C., Baiocchi, G., Blanco-Colino, R., Chaudhry, D., Alameer, E., El-Boghdadly, K., Wuraola, F., Ghosh, D., Gujjuri, R. R., Harrison, E. M., Lule, H., Kaafarani, H., Khosravi, M., Kronberger, I., Leventoglu, S., Mann, H., Mclean, K. A., Mengesha, M. G., Modolo, M. M., Ntirenganya, F., Norman, L., Outani, O., Pius, R., Pockney, P., Qureshi, A. U., Roslani, A. C., Satoi, S., Shaw, C., Bhangu, A., Omar, O. M., Ahmed, W. -U. -R., Argus, L., Ball, A., Bywater, E. P., Brar, A., Dawson, B. E., Duran, I., Elhadi, M., Jones, C. S., Kamarajah, S. K., Keatley, J. M., Lawday, S., Marson, E. J., Ots, R., Santos, I., Taylor, E. H., Trout, I. M., Varghese, C., Venn, M. L., Xu, W., Dajti, I., Gjata, A., Kacimi, S. E. O., Boccalatte, L., Cox, D., Townend, P., Aigner, F., Kronberger, I. E., Samadov, E., Alderazi, A., Hossain, K., Padmore, G., van Ramshorst, G., Lawani, I., Cerovac, A., Delibegovic, S., Gomes, G. M. A., Buarque, I. L., Gohar, M., Slavchev, M., Nwegbu, C., Agarwal, A., Martin, J., Ng-Kamstra, J., Olivos, M., Lou, W., Ren, D. -L., Calvache, J. A., Perez Rivera, C. J., Hadzibegovic, A. D., Kopjar, T., Mihanovic, J., Jimenez, P. M. A., Gouvas, N., Klat, J., Novysedlak, R., Amisi, N., Christensen, P., El-Hussuna, A., Batista, S., Lincango-Naranjo, E., Emile, S., Sandoval, D. A. A., Dhufera, H., Hailu, S., Kauppila, J. H., Arnaud, A. P., Demetrashvili, Z., Albertsmeier, M., Lederhuber, H., Loffler, M. W., Acquah, D. K., Ofori, B., Tabiri, S., Metallidis, S., Tsoulfas, G., Aguilera-Arevalo, M. -L., Recinos, G., Mersich, T., Wettstein, D., Kembuan, G., Milan, P. B., Khosravi, M. H., Mozafari, M., Hilmi, A., Mohan, H., Zmora, O., Gallo, G., Pata, F., Pellino, G., Fujimoto, Y., Kuroda, N., Abou Chaar, M. K., Ayasra, F., Fakhradiyev, I., Hamdun, I. H. S., Jin-Young, J., Jamal, M., Karout, L., Gulla, A., Rasoaherinomenjanahary, F., Samison, L. H., Sanchez, I. I. D., Gonzalez, D. S., Martinez, L., Martinez, M. J., Nayen, A., la Medina, A. R. -D., Nunez, J., Nashidengo, P. R., Shah, R., Shrestha, A. L., Jonker, P., Kruijff, S., Noltes, M., Steinkamp, P., Wright, D., Abdur-Rahman, L., Ademuyiwa, A., Adisa, A., Osinaike, B., Seyi-Olajide, J., Williams, O., Williams, E., Pejkova, S., Al Balushi, Z., Sayyed, R., Mohsen, M. A., Abukhalaf, S. A., Cukier, M., Gomez-Fernandez, H., Yip, S. S., Ojeda, X. P. V., Sacdalan, M. D., Major, P., Azevedo, J., Cunha, M. F., Zarour, A., Bonci, E. -A., Negoi, I., Efetov, S., Kochetkov, V., Litvin, A., Ingabire, J. A., Bucyibaruta, G., Faustin, N., Habumuremyi, S., Imanishimwe, A., de Dieu, H. J., Munyaneza, E., Ncogoza, I., Ndong, A., Radenkovic, D., Chew, M. H., Koh, F., Ngu, J., Panyko, A., Bele, U., Kosir, J. A., Daoud, H., Bravo, A. M. M., Jayarajah, U., Wickramasinghe, D., Adam, M. E. A. E., Rutegard, M., Sund, M., Adamina, M., Gialamas, E., Horisberger, K., Alshaar, M., Huang, A., Lohsiriwat, V., Charles, S., Jlassi, H., Isik, A., Lekuya, H. M., Kopetskyi, S., Alsaadi, H., Alshryda, S., Alser, O., Bankhead-Kendall, B., Breen, K., Mashbari, H., Cal, F. B., Al-Naggar, H., Maimbo, M., Mazingi, D., Abbott, T., Akhbari, M., Benson, R., Bhanderi, S., Biccard, B., Caruana, E., Chakrabortee, S., Chapatwala, R., Costas-Chavarri, A., Demetriades, A. K., Desai, A., Di Saverio, S., Drake, T., Edwards, J., Evans, J., Fiore, M., Ford, S., Fotopoulou, C., Fowler, A., Futaba, K., Ganly, I., James, H. G., Griffiths, E., Gronchi, A., Hutchinson, P., Hyman, G. Y., Incorvia, J., Jain, R., Jenkinson, M., Khan, T., Knight, S. R., Kolias, A., Kudsk-Iversen, S., Kwan, T. Y., Leung, E., Mayol, J., Mckay, S., Meara, J. G., Mills, E., Moug, S., Patel, A., Perinotti, R., Rice, H. E., Roberts, K., Schache, A., Shaw, R., Smart, N., Stephens, M., Stewart, G. D., Teasdale, E., Vaughan-Shaw, P., Vidya, R., Wright, N., Zimmelman, N., Agastra, E., Thereska, D., Lucchini, S. M., Laudani, V., Chwat, C., Salazar, I. I. P., Pachajoa, D. A. P., Duro, A., Arancibia, J. A. C., D'Aulerio, G., Dudi-Venkata, N., Egoroff, N., Farik, S., Lott, N., Moss, J. -L., Rennie, S., Tan, L., Vo, U. G., Watson, D., Watters, D., Bright, T., Hollington, P., Zhou, X., Kroon, H. M., Farfus, A., Barker, J., Watson, E., Stevens, S., Latif, H., Dawson, A. C., Chuan, A., Muralidharan, V., Wong, E., Ackermann, T., Pacilli, M., Hodgson, R., Heriot, A., Choong, P., Brown, W., Lidder, S., Yeung, J., Traeger, L., Regalo, G., Gourlay, R., Badiani, S., Koh, C., Putnis, S., Haider, F., Mitul, A. R., Komen, N., Dhondt, B., Cappeliez, S., Pigeolet, M., Schoneveld, M., Stijns, J., Oosterlinck, W., Flamey, N., Kpangon, C., Agbadebo, M., Tobome, S. R., Barros, A. V., Junior, S. A., do Amaral Campos, H. G., Gross, J., Coimbra, F. J. F., Kowalski, L. P., Makdissi, F., Nakagawa, S., Neto, J. P. D., Vartanian, J. G., Yazbek, G., Zequi, S. C., Flumignan, R., Jaworska, N., Dell, A., Shanthanna, H., Behzadi, A., Nessim, C., Mozel, M., St-germain, P., Russell, C., Groot, G., Safieddine, N., Wijeysundera, D., Eskander, A., Chadi, S., Mackenzie, S., Flexman, A., Heredia, F., Villanueva, J., Waissbluth, S., Macchiavello, R., Escudero, M. I., Fuentes, T., Mimica, X., Saenz, D. B., Caicedo, L., Alzate, J. P., Luna, J., Alonso, N. F. P., Silva, C. O., Rodriguez, J., Silva-Igua, L., Torres, M. L., Trujillo, L. M., Calvache, A. J. N., Balanta-Melo, J., Figueroa-Casanova, R., Garcia-Montoya, O. -J., Toro, C. A. M., Botero, M. V., Arango, M. C. M., Martinez, E. D., Perdomo, V. G., Montenegro, E., Rodriguez-Abreu, J., Mejia, D., Abouelnagah, G., Shehata, S., Rida, A. H. E. F., Hassan, R. A., Saad, M. M., Loaloa, M. R., Mostafa, B., Qassem, M., Fahmy, M., Abozied, H., Azzam, A. Y., Ghozy, S., Sallam, A., Shehta, A., Abdelkhalek, M., Samaka, R., Morsy, A., Sherif, A. E., Negussie, A., Fisseha, T., Shumbash, K., Abebe, M., Yasin, S. M., Akililu, Y. B., Megersa, A., Tefera, T., Assefa, M., Atnafu, B., Tsegaye, B., Bezabih, Y. S., Sisay, S., Bekele, K., Jira, M., Derilo, H., Degefa, E., Tadesse, A., Nidaw, M., Sarjanoja, E., Testelin, S., Boucher, S., Jouffret, L., Lakkis, Z., Le Bian, A. Z., Harper, L., des Deserts, M. D., Andre, B., Slim, K., Verhaeghe, R., Police, A., Girard, E., Chebaro, A., Nkembi, A. S., Arnalsteen, L., Ballouhey, Q., Mege, D., Jeandel, C., Duchalais, E., Bouche, P. -A., Manceau, G., Cretolle, C., Hervieux, E., Girard, N., Seguin-Givelet, A., Gaujoux, S., De Simone, B., Boisson, M., Bergeat, D., Fredon, F., Nappi, F., Kassir, R., Scalabre, A., Migliorelli, F., Ezanno, A. -C., Seeliger, B., Vaysse, C., Charbonneau, H., Misrai, V., Abbo, O., Angeles, M. A., Brunaud, L., Modabber, A., Wolf, S., Kamphues, C., Hohn, P., Glowka, T. R., Rokohl, A. C., Bork, U., Fluegen, G., Horch, R. E., Schmedding, A., Schnitzbauer, A., Eberbach, H., Schlager, D., Spelsberg, F., Keppler, L., Hecker, A., Wolfer, S., Ronellenfitsch, U., Nitschke, C., Peiper, C., Hakami, I., Welter, S., Nikolaieva, K., Roth, A., Lindert, J., Gousias, K., Rissmann, A., Linz, V. C., Rahbari, N., Rassweiler-Seyfried, M. -C., Gut, A. E., Gempt, J., Reim, D., Wagner, A., Keppler, A. M., Stoleriu, M. G., Saier, T., Stadler, J., Kaiser, J. C., Brunner, S. M., Pfister, K., Herzberg, J., Nowak, K., Reinhard, T., Stavrou, G. A., Konigsrainer, A., Konrads, C., Quante, M., Laban, S., von Pusch, S., Hirschburger, M., Doerner, J., Wiegering, A., Tampaki, E. C., Ruiz, A. G., Rodas, A., Portilla, A. L., Carrera, J., Duarte, A. B., Lowey, M., Barillas, S., Suroy, A., Vaishnav, D., Chowdappa, R. G., Madabhavi, I., Bhat, D., Venkatappa, S. 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S., Shaheen, A., Mohammed, Y. S., Shehata, A., Shemeis, M., Shenit, K., Sheta, M., Soffar, A., Tanas, Y., Tarek, A., Yehia, N., Eid, O. K. M., Abdulfattah, A. Y., Elsaghir, A., Elganainy, M. F., Elsayed, O. I., Elmandouh, O., Hamam, O., Shehata, M. A., Abdelaziz, A. A., Abbas, A. M., El-Ghani, W. A., Abd Elazeem, H. A. S., Elsayed, M. A., Abd-Elkariem, A. Y., Abdalla, S., Abdel-Aleem, M., Abdelazeem, K., Abdelfattah, M., Abdelhafez, M., Abdelkarem, M. M., Abdelraouf, A., Abdullaha, L., Abubeih, H., Ahmed, M. E., Ahmed, N. E. A. E., Saad, S. A., Alaa, S., Alhussaini, A., Ali, A. A. A., Ali, I., Ali, W., Mohamed, M. A., Ashraf, M., Bassiouni, M., El-adawy, M. G., El-Sharkawi, M., Elkhayat, H., Elmaghraby, K., Elsdfy, S., Elsharkawy, M., Eltayeb, A., Mohamed, M. E., Essam, E., Fahd, M., Farouk, O., Gadelkareem, R., Ghoneim, A., Takrouney, M. H., Hamdan, A., Hamed, A. E. -R., Hasan, A., Hassanin, M. A., Hawal, I., Henes, K., Herdan, M. O., Hetta, H. F., Ibrahem, O., Ibrahim, I. H., Kamel, M., Khallaf, M., Elghazaly, S. M., Mahfouz, A., Mahmoud, O., Mahran, W., Mahrous, D., Marsis, A., Hussein, A. M., Sayed, A. M., Mohammed, M. M., Mokhtar, A., Monib, F. A., Nageeb, A., Nageh, M. A., Nageh, M., Omar, N. G., Ragab, A., Ramadan, A., Temerik, A. R., Safwat, H., Salah, O., Mahmoud, A. E. S., Saleh, A., Sallam, M., Samir, A., Sayad, R., Sayed, E., Sedik, A. S., Shahine, M., Soliman, A., Soliman, W., Taher, M. G., Wanees, R., Yousof, E. A., Youssef, A., Elabedeen, O. Z., Hassan, A. E. S., Fattah, S. A., Abostate, A., Ali, S., Salama, S. A. S., Allam, M., Alsadek, A., Arafa, E., Barakat, A., El Sherpiny, M., Elbehairy, G., Eleisawy, M., Elgendy, A., Elhawary, R., Eltregy, S., Hamdy, M., Hassan, G., Khalifa, A., Mahmoud, A., Altukhy, A. M., Noah, K., Noureldin, Y., Nowar, M., Saad, M., Elsaeidy, A. S., Elsaeidy, K. S., Sabry, H., Sameh, M., Said-elnaby, A. T., Zahed, M., Zahran, M., Zaid, A., Zoghary, A. Z., Atef, M., Abdelhamid, M. H. S., Alazab, E., Awad, A. K., Darwesh, A., El Fiky, L., Elgarhy, I., Nassef, M. A., Shaban, M., Shalaby, M. M. M., Wahba, A., Fouad, O. Y. O., Elsadek, M., Gad, D., Abdelsamed, A., Bayomy, A., Elsalhy, M., Fahim, A., Seleim, A., Afifi, E., Gamal, F. A., Gamal, M., Eldesouky, O., Eldwini, M. H. E. E., Fahmy, M. M. F., Hussein, A., Ouf, A., Sami, O., Shaat, S., Bahi, A. W. M. K., Atea, A., Gamal, I., El Kassas, M., Omar, W., Tawheed, A., Al-oribi, S., Aly, N. K., Elfiky, M., Elmaghraby, A. E., Elrahmany, A., Elsherbeeny, M., Helmy, Y., Nabil, A., Farahat, A. S., Soliman, M., Wassef, A., Abdelrahman, A., Elsaban, S., Ghaly, G., Hamdy, R., Mondy, H., Abdallah, L., Darwish, A. K. Z., Rabea, M., Azab, M. A., Abbas, A. S., El-Deeb, M., Fawzy, M., Ibraheem, M., Bakry, A., Elnems, S., Elsheikh, R., Gbreel, M. I., Hafez, M., Jammal, M., Hamam, K. M., Makram, A. M., Makram, O. M., Rabie, S., Askalany, S. Y., Abushanab, M. M. I., Eid, A., El Ghalid, M. R. I. A., Abdelaty, A. A., Fayad, E. A., Radwan, A., Shokry, A., Farouk, A. M., Elfallal, A., Elfeki, H., Elsaeed, M., Elsaid, M., Makroum, A., Elsaid, D. M., Mostafa, M., Omar, M. W., Rezk, M., Sakr, A., Sanad, A., Shalaby, M., Shawqy, M., Shetiwy, M., Shoma, A., Tawakl, N., Yunes, A., Abouzid, A., Atallah, K., Elmorsi, R., Elsherbini, A., Gaballa, K., Hamdy, O., Metwally, I. H., Refky, B., Zuhdy, M., Zahran, M. A., Abdellah, F., Abdelmawla, A., Abdrabou, A., Abubakr, A., Al Gohary, R., Al-Shazly, M. H., Allam, A. R., Aposaeeda, A., Asfour, M., Ayman, A., Omran, A. A., Daghash, I. T., Ebada, M. A., Eid, T., El Kelany, A., El Shemy, E., El-Hag-Aly, M., Elgamal, O., Elghoury, M., Elkased, A. F., Ellakwa, T. H., Ellakwa, H., Elmeanawy, A., Elnoamany, S., Elsabagh, A., Elsawey, A., Elshabrawy, E., Elshakhs, S., Elsoudy, N., Ezzat, E., Fawzy, A., Gamal, A., Gameel, A., Gharbia, K., Ghonaim, M., Ghonaim, A., Hafez, A., Ismail, Z., Khaled, M., Meselhy, M., Mikhail, P., Mougahed, M., Mustafa, A., Nada, A., Omran, J., Ebiad, M. S., Saleh, I., Salem, N., Salem, O., Selim, S., Shalaby, G., Sherif, H., Soltan, H., Wahbah, M., Abdelbary, E. Z., Zayan, A. H., Afify, A., Hadiya, H. A., Elshref, M. J., Ahmed, M. M., Nasser, N., Abdeldayem, H., Salama, I. A., Ammar, K., Ayoub, I., Badawy, M. T., Balabel, M., Fayed, Y., Gad, E. H., Gomaha, M., Hammad, E., Hegazy, O., Hegazy, E., Ibrahim, T., Kallaf, M., Macshut, M., Magdy, A., Oteem, A., Samaan, S., Sharshar, M., Shoreem, H., Soliman, E., Soliman, H. E., Yassein, T., Zakaria, H., Eldaly, A., Mashaly, S., Abd-Elsalam, S., Abdel-Elsalam, W., Shaalah, A. A., Elbahnasawy, M., Elhalaby, I., Hamada, M., Soliman, S. H., Hawila, A., Morsy, M. S., Naieem, M., Nasreddin, M., Salman, S., Sarsik, S., Shabana, A., Tolba, E., Zagho, M., Kams, L., Ratsep, T., Riips, K., Abdurehman, O., Admasu, A., Berhea, A., Eado, Y., Hailu, N., Kidane, M., Mohammed, A., Mohammed, K., Tibelt, A., Woldemariam, M. A., Yonael, L., Alemu, M., Aklilu, A. T., Asele, F., Assefa, S., Azmach, D., Bekele, P., Mamo, M., Maru, N., Mekuria, H., Menkir, A., Mikru, F., Siraw, E., Suga, H., Sumoro, N., Teka, A., Thomas, E., Woldemariam, D., Wubishet, E., Abebe, E., Abebe, K., Asfaw, F., Bergene, E., Eshete, M., Gebrehiwot, F. G., Gedefaw, Y., Mengesha, M. W., Mengiste, N., Menjeta, A., Muleta, M. B., Sefera, S., Tedla, Y., Teklu, D., Teshome, H., Tirfe, L., Tsegabrhan, S., Tsehaye, M., Worku, B., Molla, M., Supha, M., Taye, T., Abebe, N., Alemu, B., Chanie, A., Degefu, H., Desalegn, D., Gebre, H., Hussen, H., Kassa, D., Laeke, T., Mammo, T. N., Negash, S., Sahlu, A., Tiruneh, A. G., Wolde, A., Woldeselassie, H. G., Ahmed, M. Y., Zewdneh, B., Fentaw, J., Salia, S., Tabore, K., Gurara, A., Abreha, T., Abrha, T., Beyene, G., Weldu, M. A., Abdissa, D., Tesfaw, M., Wolle, M., Asmamaw, D., Assefa, B. Z., Bedane, D., Bekele, E., Getie, A., Melkamu, S., Mengesha, W., Shumye, G., Tagele, G., Tesfa, A. A., Workneh, W., Genetu, S., Mebratu, E., Chanyalew, L., Deresse, T., Girma, A., Seid, M., Shimelash, D., Shitaw, A., Ayalew, T., Diress, T., Kassahun, B., Kassaye, B., Mulugeta, E., Tesfaw, G., Yimenu, B., Benecha, S., Aman, M., Mekete, A., Tesemma, A., Mohammed, A. A., Abdullahi, Y. Y., Adem, E., Ahmedin, M., Assefa, Y., Ayde, F., Berhe, A., Gebremeskel, Z., Siyoum, E. G., Teresa, S., Wude, Z., Yemer, F., Yohannes, D., Zeleke, E., Zerihun, G., Degefe, D. W., Derilo, H. T., Eliyas, N., Bayissa, F., Deressa, Y., Gemechu, L., Gurmu, T., Kasaye, A., Melese, L., Muleta, L., Mulugeta, G., Taye, S., Teshome, A., Tesso, B., Gebrekirstos, G., Haile, M., Kassa, H., Saddik, M., Mengist, A., Heikkinen, J., Helminen, O., Huhta, H., Kotkavaara, T., Mosorin, M. -A., Pitkanen, J., Qian, C., Sinikumpu, J., Sova, H., Tastula, M., Virta, V. P., Bettoni, J., Dakpe, S., Devauchelle, B., Lavagen, N., Bastard, F., Bin, K., Breheret, R., Fouquet, O., Gueutier, A., Henric, N., Kahn, A., Kun-Darbois, J. -D., Moukoko, D., Pineau, A., Podevin, G., Schmitt, F., Alshawared, F., Beyrne, C. D., Lugans, L., Marie-Macron, L., Doussot, A., Ahmed, O., Alnajjar, L., Mis, T. C., Fliss, S., Giocanti-Auregan, A., Gregory, T., Guiraudet, P., Le Fouler, A., Martinod, E., Onorati, I., Peretti, M., Quilichini, J., Radu, D., Tresallet, T., Andro, C., Maffert, A., Chapman, T., Halden, M., Fayon, J., Mattevi, C., Marion, H., Bendjemar, L., Lionel, C., Mikhael, E., Macias, R. M., Villefranque, V., Volpin, E., Trilling, B., Boleslawski, E., Constance, H. -L., Drubay, V., El Amrani, M., Eveno, C., Lecolle, K., Martin, L., Noiret, B., Piessen, G., Truant, S., Zerbib, P., Aubry, E., Denimal, F., Lamblin, A., Barrat, B., Caire, F., Christou, N., Fourcade, L., Laloze, J., Bouv-Hez, M. M., Salle, H., Taibi, A., Tricard, J., Usseglio, J., Chopinet, S., Gregoire, E., Delpont, M., Blanchard, C., Crenn, V., de Vergie, S., Denis, W., Fragnaud, H., Regenet, N., Rigaud, J., Varenne, Y., Anract, P., Barat, M., Biau, D., Dautry, R., Dohan, A., Idier, L., Lang, E., Thouny, C., Tzedakis, S., Audenet, F., Cazelles, A., Chamouni, A., Karoui, M., Mejean, A., Clermidi, P., Langlais, T., Leonelli, L., Maisonneuve, E., Nicolas, B., Perrot, O., Prost, D., Thomin, A., Thouement, T., Athiel, Y., Berry, R., Boddaert, G., Bonnet, S., Cathala, N., Conso, C., Denet, C., Laforest, A., Levy-Zauberman, Y., Macek, P., Mombet, A., Ollat, D., Scamporlino, A., Zadegan, F., Amine, C. A., Baratte, B., Chartier-Kastler, E., Chereau, N., Colas, P. -A., Duquesne, I., Genser, L., Petit, G. G., Goumard, C., Hasani, A., Lim, C., Martellotto, S., Melot, C., Menegaux, F., Pinar, U., Pocard, M., Roupret, M., Scatton, O., Seisen, T., Severine, N., Turco, C., Chouillard, E., Beganton, P., Frasca, D., Kerforne, T., Corbiere, L., Gasmi, A., Ghemame, M., Guerin, S., Khene, Z. -E., Livin, M., Mahmoud, F., Maillot, B., Merdrignac, A., Mouriaux, F., Robin, F., Sulpice, L., Vazeux, C., Bertheuil, N., Bonneau, S., Cazemajou, C. T., Cousin, I., Defert, C., Fustec, E., Juricic, M., Lavoue, V., Mevel, G., Timoh, K. N., Renault, A., Violas, P., Schwarz, L., Tuech, J. J., Morichau-Beauchant, T., Sauvat, F., Haddad, E., Vermersch, S., Patrizi, A., Roux, A., Aime, A., Malgras, B., Cherkaoui, Z., D'Urso, A., Felli, E., Gonzalez, C. A., Ignat, M., Mutter, D., Pessaux, P., Vix, M., Gornes, H., Vergriete, K., Berthoumieu, P., Genre, L., Le Gall, H., Pierre, T., Chalhoub, M., Del, M., Martinez, A., Fuchs-Buder, T., Vancon, A., Faya, C. A., Asaph, E., Baruwa, E., Hofman, G., Machemedze, S., Idiata, M. M., Muhemi, R., Ndizeye, O., Nkunzimana, E., O'Connor, J., O'Connor, Z., Tchoba, S., Boumas, N., Devidze, G., Pisarevi, G., Baumgarten, S., Grusser, L., Holzle, F., Kowark, P., Kowark, A., Rossaint, R., Schafer, B., Wallqvist, J., Winnand, P., Ziemann, S., Anthuber, M., Broecheler, T., Edlinger, F., Gosslau, Y., Hyhlik-Duerr, A., Maksymiw, F., Shiban, E., Sommer, F., Sommer, B., Zerwes, S., Beyer, K., Lauscher, J. C., Lee, L. D., Loch, F. N., Schineis, C., Aghalarov, I., Belyaev, O., Braumann, C., Enste, A., Fahlbusch, T., Herzog, T., Horn, J., Jedanowski, J., Knipschild, J., Luu, A. M., Mohan, P. V., Siemen, L., Slobodkin, I., Strotmann, J. J., Uhl, W., Wolf, K., Coburn, M., Egger, E., Eichhorn, K., Enderes, J., Far, F., Franzen, A., Guresir, E., Hadjiathanasiou, A., Kalff, J. C., Kohistani, Z., Manekeller, S., Mustea, A., Probst, C., Randau, T., Recker, F., Schuss, P., Strassberger-Nerschbach, N., Strieth, S., Treede, H., van Beekum, C. J., Vatter, H., Velten, M., Vilz, T. O., Wirtz, D., Wittmann, M., Behr, M., Bulian, D. R., Marche, B., Moczko, T., Otchwemah, R., Schulz, S. -A., Thomaidis, P., Bruns, C., Cursiefen, C., Domrose, C., Fuchs, H., Heindl, L. M., Mallmann, M. R., Mallmann, C., Ratiu, D. A., Canzler, U., Distler, M., Korn, S., Meisel, C., Meusel, M., Petzold, A., Praetorius, C., von Renesse, J., Weitz, J., Wimberger, P., Alkhanji, N., Fung, S., Jaber, K., Knoefel, W. T., Vay, C., Clonda, O., Cottin, T., Juodiene, E., Juodis, D., Petrovic, B., Solodarenko, O., Binder, J., Grutzmann, R., Hackner, D., Junker, S., Arsalan, M., Banek, S., Chun, F., Faqar-Uz-Zaman, S. F., Keese, D., Kluth, L., Rolle, U., Van Linden, A., Walther, T., Bayer, J., Beck, J., Fung, C., Kraus, L. M., Leiber, C., Neidert, N., Sandkamp, R., Schnell, O., Schulte, A., Strahle, J., Jarmusch, S., Novotny, H. F. G., Becker, J., Fulghum, C., Gonschor, B., Herbolzheimer, M., Nicolaiciuc, S., Trulson, A., Vogelsang, H., Zimmermann, B., Akbari, A. A., Boening, A., Edinger, F., Hecker, M., Knitschke, M., Koch, C., Reichert, M., Schmidt, G., Schneck, E., Uhl, E., Nobrega, S. F., Kauffmann, P., Miller, C., Nemeth, M., Sievers, D., Kisser, U., Kleeff, J., Klose, J., Lorenz, K., Papendick, N., Plontke, S., Seiwerth, I., Steer, S., Thomssen, C., Ukkat, J., Dumpies, C. W., Gessner, M., Hanke, J., Klauke, F., Leuschner, S., Mendel, T., Muller, K., Schmidt, B., Schreiter, V., Stosberg, P., Vinz, F., Herbig, B., Sander, J., Schulte, T. M., Betz, C. S., Bewarder, J., Bier, J., Bottcher, A., Burg, S., Busch, C. -J., Bussmann, L., Gosau, M., Heuer, A., Izbicki, J., Klatte, T. O., Konig, D., Kopke, L. -G., Moeckelmann, N., Praetorius, M., Priemel, M., Stadlhofer, R., Stangenberg, M., Uzunoglu, F. 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A., Workneh, W., Genetu, S., Mebratu, E., Chanyalew, L., Deresse, T., Girma, A., Seid, M., Shimelash, D., Shitaw, A., Ayalew, T., Diress, T., Kassahun, B., Kassaye, B., Mulugeta, E., Tesfaw, G., Yimenu, B., Benecha, S., Aman, M., Mekete, A., Tesemma, A., Mohammed, A. A., Abdullahi, Y. Y., Adem, E., Ahmedin, M., Assefa, Y., Ayde, F., Berhe, A., Gebremeskel, Z., Siyoum, E. G., Teresa, S., Wude, Z., Yemer, F., Yohannes, D., Zeleke, E., Zerihun, G., Degefe, D. W., Derilo, H. T., Eliyas, N., Bayissa, F., Deressa, Y., Gemechu, L., Gurmu, T., Kasaye, A., Melese, L., Muleta, L., Mulugeta, G., Taye, S., Teshome, A., Tesso, B., Gebrekirstos, G., Haile, M., Kassa, H., Saddik, M., Mengist, A., Heikkinen, J., Helminen, O., Huhta, H., Kotkavaara, T., Mosorin, M. -A., Pitkanen, J., Qian, C., Sinikumpu, J., Sova, H., Tastula, M., Virta, V. 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M., Salle, H., Taibi, A., Tricard, J., Usseglio, J., Chopinet, S., Gregoire, E., Delpont, M., Blanchard, C., Crenn, V., de Vergie, S., Denis, W., Fragnaud, H., Regenet, N., Rigaud, J., Varenne, Y., Anract, P., Barat, M., Biau, D., Dautry, R., Dohan, A., Idier, L., Lang, E., Thouny, C., Tzedakis, S., Audenet, F., Cazelles, A., Chamouni, A., Karoui, M., Mejean, A., Clermidi, P., Langlais, T., Leonelli, L., Maisonneuve, E., Nicolas, B., Perrot, O., Prost, D., Thomin, A., Thouement, T., Athiel, Y., Berry, R., Boddaert, G., Bonnet, S., Cathala, N., Conso, C., Denet, C., Laforest, A., Levy-Zauberman, Y., Macek, P., Mombet, A., Ollat, D., Scamporlino, A., Zadegan, F., Amine, C. A., Baratte, B., Chartier-Kastler, E., Chereau, N., Colas, P. -A., Duquesne, I., Genser, L., Petit, G. G., Goumard, C., Hasani, A., Lim, C., Martellotto, S., Melot, C., Menegaux, F., Pinar, U., Pocard, M., Roupret, M., Scatton, O., Seisen, T., Severine, N., Turco, C., Chouillard, E., Beganton, P., Frasca, D., Kerforne, T., Corbiere, L., Gasmi, A., Ghemame, M., Guerin, S., Khene, Z. -E., Livin, M., Mahmoud, F., Maillot, B., Merdrignac, A., Mouriaux, F., Robin, F., Sulpice, L., Vazeux, C., Bertheuil, N., Bonneau, S., Cazemajou, C. T., Cousin, I., Defert, C., Fustec, E., Juricic, M., Lavoue, V., Mevel, G., Timoh, K. N., Renault, A., Violas, P., Schwarz, L., Tuech, J. J., Morichau-Beauchant, T., Sauvat, F., Haddad, E., Vermersch, S., Patrizi, A., Roux, A., Aime, A., Malgras, B., Cherkaoui, Z., D'Urso, A., Felli, E., Gonzalez, C. A., Ignat, M., Mutter, D., Pessaux, P., Vix, M., Gornes, H., Vergriete, K., Berthoumieu, P., Genre, L., Le Gall, H., Pierre, T., Chalhoub, M., Del, M., Martinez, A., Fuchs-Buder, T., Vancon, A., Faya, C. A., Asaph, E., Baruwa, E., Hofman, G., Machemedze, S., Idiata, M. M., Muhemi, R., Ndizeye, O., Nkunzimana, E., O'Connor, J., O'Connor, Z., Tchoba, S., Boumas, N., Devidze, G., Pisarevi, G., Baumgarten, S., Grusser, L., Holzle, F., Kowark, P., Kowark, A., Rossaint, R., Schafer, B., Wallqvist, J., Winnand, P., Ziemann, S., Anthuber, M., Broecheler, T., Edlinger, F., Gosslau, Y., Hyhlik-Duerr, A., Maksymiw, F., Shiban, E., Sommer, F., Sommer, B., Zerwes, S., Beyer, K., Lauscher, J. C., Lee, L. D., Loch, F. N., Schineis, C., Aghalarov, I., Belyaev, O., Braumann, C., Enste, A., Fahlbusch, T., Herzog, T., Horn, J., Jedanowski, J., Knipschild, J., Luu, A. M., Mohan, P. V., Siemen, L., Slobodkin, I., Strotmann, J. J., Uhl, W., Wolf, K., Coburn, M., Egger, E., Eichhorn, K., Enderes, J., Far, F., Franzen, A., Guresir, E., Hadjiathanasiou, A., Kalff, J. C., Kohistani, Z., Manekeller, S., Mustea, A., Probst, C., Randau, T., Recker, F., Schuss, P., Strassberger-Nerschbach, N., Strieth, S., Treede, H., van Beekum, C. J., Vatter, H., Velten, M., Vilz, T. O., Wirtz, D., Wittmann, M., Behr, M., Bulian, D. R., Marche, B., Moczko, T., Otchwemah, R., Schulz, S. -A., Thomaidis, P., Bruns, C., Cursiefen, C., Domrose, C., Fuchs, H., Heindl, L. M., Mallmann, M. R., Mallmann, C., Ratiu, D. A., Canzler, U., Distler, M., Korn, S., Meisel, C., Meusel, M., Petzold, A., Praetorius, C., von Renesse, J., Weitz, J., Wimberger, P., Alkhanji, N., Fung, S., Jaber, K., Knoefel, W. T., Vay, C., Clonda, O., Cottin, T., Juodiene, E., Juodis, D., Petrovic, B., Solodarenko, O., Binder, J., Grutzmann, R., Hackner, D., Junker, S., Arsalan, M., Banek, S., Chun, F., Faqar-Uz-Zaman, S. F., Keese, D., Kluth, L., Rolle, U., Van Linden, A., Walther, T., Bayer, J., Beck, J., Fung, C., Kraus, L. M., Leiber, C., Neidert, N., Sandkamp, R., Schnell, O., Schulte, A., Strahle, J., Jarmusch, S., Novotny, H. F. G., Becker, J., Fulghum, C., Gonschor, B., Herbolzheimer, M., Nicolaiciuc, S., Trulson, A., Vogelsang, H., Zimmermann, B., Akbari, A. A., Boening, A., Edinger, F., Hecker, M., Knitschke, M., Koch, C., Reichert, M., Schmidt, G., Schneck, E., Uhl, E., Nobrega, S. F., Kauffmann, P., Miller, C., Nemeth, M., Sievers, D., Kisser, U., Kleeff, J., Klose, J., Lorenz, K., Papendick, N., Plontke, S., Seiwerth, I., Steer, S., Thomssen, C., Ukkat, J., Dumpies, C. W., Gessner, M., Hanke, J., Klauke, F., Leuschner, S., Mendel, T., Muller, K., Schmidt, B., Schreiter, V., Stosberg, P., Vinz, F., Herbig, B., Sander, J., Schulte, T. M., Betz, C. S., Bewarder, J., Bier, J., Bottcher, A., Burg, S., Busch, C. -J., Bussmann, L., Gosau, M., Heuer, A., Izbicki, J., Klatte, T. O., Konig, D., Kopke, L. -G., Moeckelmann, N., Praetorius, M., Priemel, M., Stadlhofer, R., Stangenberg, M., Uzunoglu, F. G., Wittig, L., Zech, H., Zeller, N., Roux, F., Spaeth, T., Fricker, R., Muller, T., Schroder, L., Alasmari, M., Boeker, C., Hakami, I. A., Mall, J. W., Kyritsis, I., Graeb, C., Huber-Strossner, K., Branzan, D., Doss, M., Gockel, I., Jodicke, C., Osterhoff, G., Pempe, C., Sucher, R., Adler, T., Kelly, K., Merkle, J., Siebert, J., Hirche, C., Kneser, U., Tapking, C., Agrawal, R., Qureischie, H., Croner, R., Koslowski, L., Krause, H., Meyer, F., Turial, S., Al-Nawas, B., Battista, M. J., Goedeke, J., Hasenburg, A., Heider, J., Mueller, L. K., Zeller, S., Jentschura, S. L. P., Kowalewski, K. -F., Kriegmair, M., Mannle, D., Reissfelder, C., Rotter, N., Scherl, C., Seyfried, S., Kirschniak, A., Rolinger, J., Wilhelm, P., Bader, F. G., Ottl, S., Behr, A. V., Diamantis, A., Fichter, A., Grill, F., Heck, M., Jira, D., Kallmayer, M., Koll, F., Luhne, S., Meyer, B., Patachia, R., Pergolini, I., Safi, S., Schaffer, C., Schirren, M., Wegmann, H., Wirth, M., Zhu, Z., Aghamaliyev, U., Almaghrabi, M., Bocker, W., Bruder, J., Frank, K., Herterich, V., Huber, V., Ilmer, M., Kammerlander, C., Neuerburg, C., von Ehrlich-Treuenstatt, V. H., Werner, J., Borner, N., Fegg, F., Hartmann, D., Ladurner, R., Liokatis, P., Patzer, K., Schlager, J. G., Smolka, W., Zimmermann, P., Hatz, R., Steinhart, D., Glowalla, C., Schneidmueller, D., Henkel, K. W., Steiner, M., Holz, K., Knorr, C., Kuehlmann, B., Oikonomou, K., Prantl, L., Flurschutz, R., Honarpisheh, H., Kroger, M., Lepiorz, D., Luths, C., Niemeier, A., Sras, Y., Strate, T., Winter, T., Freiman, T., Gessler, F., Won, S. -Y., Widyaningsih, R., Hoffmann, S., Schafer, R. C., Thiel, J. T., Bertolani, E., Steidle, C., Uberruck, L., Yurttas, C., Ziegler, P., Zimmermann, A., Bolenz, C., Dayan, D., Greve, J., Hoffmann, T. K., Janni, W., Lobig, N., Schochter, F., Vahl, J. M., Wezel, F., Greif, V., Schmidbauer, S., Marsch, I., Schneider, R., Boenicke, L., Degener, S., Dreger, N. M., Horstmeier, F. C., Kruschwitz, J., Rombach, A., Schmidt, N., Seiberth, R., Singh, J., Smit, M., von Rundstedt, F. -C., Zirngibl, H., Diessner, J., Friedrich, S., Germer, C. -T., Helmer, P., Herrmann, J., Kranke, P., Kubler, H., Lock, J., Lotz, C., Meffert, R., Meybohm, P., Muller, S., Notz, Q., Popp, M., Schlegel, N., Schlesinger, T., Schmid, B., Sitter, M., Steinisch, A., Treutlein, A., van den Berg, A., Wurmb, T. E., Agyeman-Duah, N. K., Appiah, E., Armah, R., Asare, C., Awere-Kyere, L., Daary, D., Gakpetor, D., Allah, S. M., Obbeng, A., Osei-Poku, D., Puozaa, D., Tackie, E., Adu-Aryee, N. A., Agboadoh, N., Asare, O., Bowan, A. B., Brown, G. D., Clegg-Lamptey, J. -N., Dedey, F., Dery, C., Fenu, B. S., Harrison, M. A., Kumassah, P., Kuuzie, E., Nsaful, J., Olayiwola, D. O., Smith, C., Banka, C., Hussey, R., Azize, D. A., Aniakwo, L. A., Adofo-Asamoah, Y., Agbeno, E. K., Agyapong, M. M., Agyen, T., Mensah, K. A., Alhassan, B. A. B., Amoako-Boateng, M., Appiah-Thompson, P., Gyimah, N. A. -M., Asante-Bremang, M., Asante-Asamani, A., Atawurah, H., Appiah, A. B., Baidoo, R. O., Baidoo, E. I., Boakye, B., Boateng, A., Dadoe, D., Dayie, M. S. C. -J. K., Debrah, S., Doku, K., Enti, E., Ken-Amoah, S., Koggoh, P., Kpangkpari, R., Maison, P., Mensah, S., Mensah, P., Mensah, T. A., Morna, M. T., Nimako-Mensah, J., Nkrumah, J., Nortey, M., Ofori, E. O., Opandoh, I. N. M., Osei-Tutu, E., Adae, J. O., Quansah, K., Quartson, E., Rahman, G. A., Walawah, D., Yigah, M., Yussif, S., Jiagge, N., Nachelleh, E., Acquaye, J., Agbedinu, K., Agyei, F., Agyemang-Prempeh, A., Amo-Antwi, K., Amoah, M., Amoah, G., Amoako, Y. A., Aning, D. G., Ankobea-Kokroe, F., Mintah, D. A., Anyitey-Kokor, D., Appiah-kubi, A., Arthur, J., Ativor, V., Barnor, I., Braimah, Y., Darko-Asante, R., Davor, A., Issahalq, M. D., Dzogbefia, M., Emile, T., Fiifi-Yankson, P., Gaveh, V., Gudugbe, S., Gyabaah, S., Gyamfi, F. E., Gyedu, A., Gyimah, D., Hammond, B., Jonathan, B. -Y., Joseph, Y., Konney, T. O., Konney, A., Kusi, K., Kyei, I., Lovi, A., Naabo, N., Nimako, B., Nyadu, B., Nyarko, O. O., Ofosu-Barko, B. B., Oppong, P. P., Osabutey, A., Poku, M., Sagoe, R., Yifieyeh, A., Ansong, G., Abass, A., Abdul-Mumin, A., Adjeso, T., Alatiiga, J. A., Amadu, M., Annan, N., Leal, G. A., Bukari, M., Buunaaim, A., Cheyuo, E., Salifu, L. D., Damah, M., Dery, M., Dzantor, E. K., Garcia, O. G., Baba, Y. I., Issaka, A., Muntaka, A. -J. M., Murphy, J., Agyeman, Y. N., Amankwaa, W. O., Osman, I., Pie, S., Seidu, A. S., Sheriff, M., Charadan, A. M. S., Titigah, A., Yahaya, M., Yakubu, M., Yenli, E. M. T. -A., Grypiotis, I., Kiriakopoulos, N., Koliopoulos, G., Kyvelos, V., Micha, G., Papadopoulou, T., Balalis, D., Fradelos, E., Korkolis, D., Alexakis, N., Angelou, K., Haidopoulos, D., Prodromidou, A., Rodolakis, A., Thomakos, N., Psychogios, D., Antonakis, P., Bramis, K., Chardalias, L., Contis, I., Dafnios, N., Dellaportas, D., Dimitra, P., Fragkoulidis, G., Gkiokas, G., Gklavas, A., Hadjizacharias, T., Karageorgou, D., Konstadoulakis, M., Kontopoulou, C., Massaras, D., Memos, N., Papaconstantinou, I., Politis, D., Polydorou, A., Stamatis, K., Theodosopoulos, T., Vezakis, A., Avgerinos, K., Katunin, J., Kechagias, A., Kelgiorgi, D., Kritikos, N., Pengerma, P., Bisdas, T., Ioannidis, A., Konstantinidis, M., Konstantinidou, S., Patelis, N., Antonopoulou, M. I., Deskou, E., Kalles, V., Manatakis, D. K., Stamos, N., Tasis, N., Arkadopoulos, N., Danias, N., Economopoulou, P., Frountzas, M., Kokoropoulos, P., Michalopoulos, N., Selmani, J., Sidiropoulos, T., Vassiliu, P., Paraskevas, K. I., Bartziotas, D., Bouchagier, K., Galanis, I., Kalamatianos, T., Kapiris, S., Kolinioti, A., Mavrodimitraki, E., Metaxas, P., Nikova, A., Psarologos, M., Sotiropoulou, M., Stranjalis, G., Albanopoulos, K., Kondilis, P., Vrakopoulou, G. Z., Chrysovergis, A., Chrysovitsiotis, G., Giotakis, E., Kanellopoulou, V., Kyrodimos, E., Larentzakis, A., Pantos, P., Papanikolaou, V., Potamianos, S., Theodoropoulos, C., Triantafyllou, A., Triantafyllou, T., Georgousi, K., Panagiotou, P., Avramidis, E., Babis, G., Zafeiris, E., Antoniou, A., Bessias, N., Maras, D., Papas, T., Roditis, K., Tsagkos, I., Tsiantoula, P., Alexandrou, A., Baili, E., Charalabopoulos, A., Dimitroulis, D., Dorovinis, P., Garoufalia, Z., Kanavidis, P., Karavokyros, I., Karydakis, L., Kykalos, S., Kyros, E., Machairas, N., Mastoraki, A., Nikiteas, N., Papalampros, A., Schizas, D., Skotsimara, A., Stamopoulos, P., Syllaios, A., Terras, A., Tomara, N., Tsourouflis, G., Vagios, I., Zografos, C., Apostolou, K., Georgopoulos, N., Antoniou, T., Antzaka, C., Falara, A., Fragoulis, S., Ftikos, P., Matsouka, F., Perreas, K., Rellia, P., Samara, E., Smirli, A., Tasouli, A., Thanopoulos, A., Chalkias, P. L., Dedemadi, G., Mourmouris, P., Skolarikos, A., Theochari, N., Tzelves, L., Gaitanakis, S., Milas, T., Theodorakis, E., Karona, P., Kastanaki, P., Tzouganakis, A., Agalianos, C., Tsouknidas, I., Xenakis, A., Chrysos, E., Lasithiotakis, K., Nikolouzakis, T., Xenaki, S., Xynos, E., Lostoridis, E., Nagorni, E. -A., Pujante, A., Tourountzi, P., Al, A., Baxevanidou, K., Bouliaris, K., Efthimiou, M., Kalfountzos, C., Koukoulis, G., Lachanas, V., Petropoulos, K., Tsitiridis, I., Angelis, F., Arnaoutoglou, E., Baloyiannis, I., Bareka, M., Bouronikou, A., Christodoulidis, G., Daponte, A., Fergadi, M., Gkolias, N., Gkrinia, E., Hajiioannou, J., Kalogritsas, N., Karoni, E., Korais, C., Krestinidis, G., Ktisti, A., Magouliotis, D., Maiou, C., Malizos, K., Minasidou, M., Ntalouka, M., Ntziovara, A. M., Palla, E., Perivoliotis, K., Saini, F., Samara, A., Saratziotis, A., Skoulakis, C., Solomi, E., Stamoulis, K., Terzoudis, C. D., Tsironi, E., Tzovaras, G., Vallianou, K., Zacharoulis, D., Ziogkou, A., Elias, L., Maroulis, I., Mulita, F., Plachouri, K. -M., Vailas, M., Doitsidis, C., Filo, E., Gkalonaki, I., Kogia, E., Kontopoulou, K., Mitroudi, M., Panteli, C., Patoulias, I., Semkoglou, O. I., Sfoungaris, D., Valioulis, I., Astreidis, I., Christidis, P., Ioannidis, O., Loutzidou, L., Mantevas, A., Paraskevopoulos, K., Tatsis, D., Athanasiadis, A., Dagklis, T., Kalogiannidis, I., Kapetanios, G., Mamopoulos, A., Margioula-Siarkou, C., Petousis, S., Tsakiridis, I., Anthoulakis, C., Christou, C., Fantakis, A., Iordanidou, E., Kaselas, C., Panagiotidou, S., Papadopoulos, V., Papavasiliou, K., Piachas, A., Siasios, I., Spyridakis, I., Theodoridis, T., Tooulias, A., Tsiridis, E., Tsopozidi, M., Aleman, M., Brolo, E., Lemus, A. L., Greenberg, J., Chew, K. M. M., Oliva, J. R., Lima, M. A. D. L., Muralles, I. L., Solares, F., Ajcip, G., Anton, C., Cojulun, J., Flores, M. -A., Jose, N., Paiz, C. A. M., Morales, S., Najera, R., Lorenzana, E. Q., Rivera, P., Rodas, L., Santos, V., Sosa, D., Ybarra, N., Cajti, J. D. P., Regil, C., Osorio, W. A., Arriola, R. R., Tale-Rosales, L. -F., Herrera, D., Rodriguez, S. T. T., Villeda, S. A., Anicetti, J., Medina, A. M. L., Ardebol, J., Barillas, K., De Leon, F., Recinos, S., Marroquin-Alpirez, M. -A., Yax, Y., Hon, S., Liu, Y. H., Liu, A. Q., Liu, S., Chiu, H. T. N., Chow, C. M. T., Hau, V., Ip, H. W., Mak, B., Mok, C. Y., Ng, D., Siu, Y. Y. E., Wong, K. F., Pu, J. J., Su, Y. -X., Au-Yeung, K. Y., Chan, D. Y. C., Chan, A., Chan, S. M., Chang, T. C., Chiu, T. W., Chiu, W. K., He, Z., Ho, M. F., Ho, K. K. W., Ho, J. Y. K., Kung, J. W. C., Lam, C. H., Lau, R. W. H., Ling, S. K. K., Lok, H. T., Mak, T. W. C., Ng, C. -F., Ng, S., Ng, K. K. -C., Ng, C. S. H., Ong, M. T. Y., Tan, T., Tang, S. F., Teoh, J. Y. -C., Teoh, A., Tsui, B. S. Y., Wong, G. K. C., Wong, R., Wong, K. C., Yee, C. H., Antal, Z., Kalman, A., Voros, P., Bahrehmand, K., Echim, T., Novak, Z., Sztipits, T., Bihari, L. A., Hidi, L., Piros, L., Rozsa, B., Sotonyi, P., Szatai, L., Herczeg, G., Pordany, B., Tornyi, F., Dede, K., Egyed, T., Saftics, G., Kulcsicka-Gut, J., Sipos, Z., Toth, D., Patel, B., Majmudar, H., Mankad, S., Pathan, S., Sharathkumarkl, L., Sasatti, L., Mahankali, S., Annayappa, S. K. S., Agrawal, T., Anandan, P., Baindur, A., Bd, M., Savitha, C., Anitha, G. S., Harigond, S., Tejeswini, K. K., Kesarla, V., Manangi, M., Hareesh, P. B., Ranjan, J. K. R., Shetty, A., Chikkanayakanahalli, S. S., Sunil, T., Syamala, S., Tharanath, K., Atal, A., Rajagopal, N., Srinath, B. S., Nk, V., Thirumanikandan, P. L., Mishra, N., Shrivastava, S., Wadhwani, R., Ahmad, R., Haq, Z. A., Behera, P., Dhurwe, R., Haq, R., Jain, V., Karna, S., Pushpalatha, K., Raj, S., Santoshi, J. A., Singh, P., Verma, V., Waindeskar, V., Yadav, M. S., Aziz, Z., Chakraborty, K., Chappity, P., Das, G., Datta, D., Jena, S. K., Kar, M., Khuntia, S., Kumar, P., Kumar, R., Kv, A., Mishra, A., Mishra, S., Mittal, Y., Muduly, D., Panda, R., Panigrahi, S., Parija, S., Patra, S., Rout, B., Sahu, R., Sarkar, S., Singh, S., Sudha, S., Sultania, M., Tripathy, S., Varghese, P., Kansay, R., Kaushik, R., Gupta, S. K., Khare, S., Kumar, V., Mohindra, S., Patil, N., Salunke, P., Savlania, A., Singh, K., Pradeep Krishna, R. V., Narasimhan, G., Rela, M., Appukuttan, A., Goudar, S., Mallick, S., Titus, C., Chidambarasamy, E. S., Madhavan, D., Murugesan, A., Narayanasamy, K., Barani Kumar, P. B., Rajan, F., Vijayaragavan, P., Borthakur, B., Chauhan, T. S., Govil, A., Hanjoora, V. M., Srivastava, A., Tiwari, S., Vishwani, V., Pendyala, K. S., Prasad, N., Bothra, J., Deb, M., Herle, K., Jayaram, H., Kannaiyan, L., Krithiga, A., Mukta, W., Nagpal, P., Pathak, P., Banerjee, S., Chaudhary, R., Choudhary, G. R., Chugh, A., Dixit, P., Elhence, A., Gahlot, N., Garg, M., Ghuman, N. K., Jha, D., Kala, P., Kaur, A., Madduri, V., Pandey, H., Pareek, P., Pathak, M., Rathod, K. J., Rodha, M. S., Saxena, R., Sharma, N., Shekhar, S., Singh, M., Suryanarayanan, B., Vishnoi, J. R., Amin, S., Sharma, T., Murugesan, K., Ramasamy, A. B. S., Chatterjee, D., Gerber, C. G., Naskar, U., Aggarwal, G., Agrawal, S. K., Jain, P., Jain, D., Kewlani, V., Pipara, A., Priya, N., Raja, R., Shakya, S., Thambudorai, R., Kharkongor, D., Akhtar, N., Anand, A., Asnani, M., Chaturvedi, A., Chaurasia, A., Enny, L. E., Garg, S., Jaiswal, A. K., Jaiswal, S., Jaware, Y., Kala, N., Karnatak, R., Kumar, U., Shrivastava, A. K., Mehrotra, S., Mishra, B., Namrata, Ojha, B. K., Ozair, A., Pal, U. S., Pandey, A., Raja, N., Ramakant, P., Roy, A., Sachan, R., Sankhwar, S., Sankhwar, P., Sarin, D., Shukla, A., Singh, K. R., Singh, R., Singh, U., Solanki, V., Sonkar, A. A., Srivastava, C., Suryawanshi, P., Tewarson, V., Verma, R., Verma, M. L., Yadav, A., Chand, G., Chanthar, K. M. M. V., Hoysal, D., Batra, N., Bhatti, A., Chopra, R., David, S., Dhar, T., Dutt, U. K., Dutta, R., Gandhi, S., Haque, P. D., Paul Sudhakar John, B., Veetil, S. K., Kaur, G., Kumar, N., Luther, A., Mahajan, A., Mandrelle, K., Mathews, S., Michael, V., Mukherjee, P., Pargal, P., Paul, R., Phillip, A., Phillips, R., Samuel, A., Singh, N., Singh, I., Singh, A., Grewal, S. S., Singhania, A., Thirumalai, S., Varghese, A., Wesley, J., Thomas, J., Zechariah, P., Ifthikar, M. A., Mathew, R. T., Shetty, R., Vijaykumar, M. V., Hameed, B. M. Z., Ibrahim, S., Jyothish, G., Krishna, S., Mathew, S., Kumar, A. S., Sinha, P. K., Sridhar, R., Agarwal, S., Balasubramaniam, S., Chhatrapati, S., Deshpande, C., Dharia, A., Fernandes, S., Gore, M., Jayakumar, A., Mhamane, R., Nirgude, A., Parab, S., Patil, M., Peswani, A., Sahu, A., Samel, S., Shah, F., Haridas, D., Shetty, V., Abraham, B., Agarwal, V., Ahmad, Q., Asari, A., Attar, M. I., Ayyalasomayajula, N. S., Bachawat, S., Bachhav, S., Badhe, V., Badhwar, S., Basa, V. I. K. A. S., Bothara, V., Chattopadhyay, S., Chaudhari, S., Chavan, R., Chawathe, P., Dadhich, S., Dalal, A., Date, A., Deshpande, M., Dev, P., Dongre, N., Doshi, A., Gade, M., Gajjar, S., Gawande, M., Ghalme, A., Ghugare, B., Gupta, I., Jain, M., Jenasamant, S. S., Joshi, V., Kalwadia, N., Kapadia, N., Kattana, H. B. R., Kaushik, T., Kayal, A., Kovale, S., Kulkarni, Y., Kumar, K., Kumawat, K., Lad, V., Maskara, N., Mistry, R., Mohanty, S. R., Motwani, K., Mulchandani, M., Nadkarni, M., Pandey, S., Parab, M., Pardiwala, D., Patkar, A., Pawar, N., Pawar, A., Pednekar, A., Peshattiwar, V., Pokharkar, H., Potdar, O., Pothare, A., Rahmani, F., Rajput, S., Narendra, N. R., Rao, A., Rao, S., Rohela, H., Sakhrekar, R., Salunkhe, D., Sandlas, G., Sarkar, H., Satpathy, A., Sekhar, R., Shelke, Y., Shetty, S. S., Shetye, S., Kulkarni, A. S., Singal, U., Solanki, F., Sonawane, R., Thete, R., Vhatkar, R., Vora, S., Waigankar, S., Wasnik, S., Yadav, M., Yedave, R., Acharya, H., Bangar, A., Bharucha, M., Dhumane, P., Karmarkar, S., Nathani, R., Nehe, A., Nene, A., Noronha, W. J., Palapalle, N., Patel, P., Poyyil, D., Redkar, R., Shah, M., Tewari, S., Bakshi, G., Chaudhari, V., Deshmukh, A., Desoouza, A., Nair, D., Nayak, P., Patkar, S., Puri, A., Qureshi, S., Shetty, P., Shylasree, T., Thakkar, P., Thiagarajan, S., Tiwari, V. K., Voppuru, S. R., Soni, A., Soni, G., Alam, J., Bagaria, D., Bajpai, M., Bisoi, A. K., Chauhan, S., Choudhary, N., Chouhan, R. S., Chumber, S., Farooque, K., Gudala, V., Joshi, M., Kabra, A., Kale, S. S., Kumar, S., Mahajan, D., Malhotra, R., Menon, P. R., Misra, B., Mittal, S., Parshad, R., Priyadarshini, P., Sagar, S., Sharma, P. B., Sharma, V., Trikha, V., Tyagi, M., Bansal, K., Varma, K., Bhardwaj, R., Mittal, A., Ponnusamy, S., Singh, G. R., Tuli, I., Bhor, P., Dhar, S., Kale, S., Aggarwal, M., Gupta, H., Deshpande, A., Gadekar, A., Jaysingani, T., Panjwani, T., Patil, R., Vaidya, N., Vishwakarma, S. K., Wayal, U., Dutta, D., Arora, R., Dhingra, M., Garg, P. K., Huda, F., Kandwal, P., Kant, R., Seenivasagam, R. K., Joshua, L. M., Poonia, D. R., Rajput, D., Sadhasivam, S., Singh, V., Chandanwale, K., Philip, M., Thorat, V., Choudhury, Y., Das, D., Das, M., Goala, S., Laskar, F. Y., Laskar, P., Malik, K., Sarkar, A., Singha, S. T., Singha, M. N., Singha, D., Srungavarapu, G., Tapkire, R., Tling, S., Andrabi, S. M. I., Bhat, G. A., Chowdri, N., Kour, R., Parray, F., Shah, Z. A. M. I. R. A. H. M. A. D., Wani, R., Adamala, S., Gowder, R., Hegde, S., Mashitha, M. S., Sreeram, S., Ankadavar, S., Bafna, D., Dhanani, B., Ingle, N., Jadhao, P., Joseph, S., Kapote, S., Karkada, S., Lad, P., Lohia, R., Madje, S., Narasiman, V., Chisthi, M., George, G., Jothi, H., Pareed, D., Mathew, G. D. C., Abel, L., Agrawal, M., Rabindranath, B., Baldia, M., Barla, R. K., Beck, M., Benjamin, S., Bliss, J., Cherian, L., Devarakonda, S., Ete, G., George, A. J. P., and Franceschini G. (ORCID:0000-0002-2950-3395)
- Abstract
SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1–6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1–2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2–3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9–3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3–6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of
- Published
- 2022
43. Catalytic study of the conversion of ethanol into 1,3-butadiene
- Author
-
Makshina, E.V., Janssens, W., Sels, B.F., and Jacobs, P.A.
- Published
- 2012
- Full Text
- View/download PDF
44. Effectief ontwikkelingsbeleid vergt cultuur van leren en betere evaluaties
- Author
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Treurniet, M., Bedi, A.S., Bulte, E.H., Dalton, P.S., Dijkstra, A.G., Gunning, J.W., Janssens, W., Kempen, L.A.C.M. van, Kuijpers, R., Lensink, B.W., Morsink, K., Nillesen, E.E.M., Oostendorp, R.H., Pradhan, M.P., Ruben, R., Soest, D.P. van, Public Administration, Academic staff unit, and Economics, Econometrics and Finance
- Subjects
Life Science ,Anthropology and Development Studies - Abstract
Het Nederlandse ministerie van Buitenlandse Zaken spant zich in om de impact van ontwikkelingsprojecten te (laten) evalueren. Momenteel worden monitoring en evaluaties hoofdzakelijk ontworpen voor verantwoordingsdoeleinden, en zijn het soms alleen maar ‘afvinkoefeningen’. Hoe zou dit beter kunnen?
- Published
- 2021
45. The cost of a peaceful mind: Evidence from Kenya
- Author
-
Aksunger, N., Janssens, W., Pradhan, M., Economics, Tinbergen Institute, and Amsterdam Centre for World Food Studies
- Published
- 2021
46. Verifying the spin of centrifuges
- Author
-
Delbeke, J.F.A., Eklund, G., van Esch, B.P.M., Janssens-Maenhout, G., and Janssens, W.
- Published
- 2010
- Full Text
- View/download PDF
47. Contributing to shipping container security: can passive sensors bring a solution?
- Author
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Janssens-Maenhout, G., De Roo, F., and Janssens, W.
- Published
- 2010
- Full Text
- View/download PDF
48. Altered responses to 5-hydroxytryptamine in hypertension and other cardiovascular disorders
- Author
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Van Nueten, J. M., Janssens, W. J., Janssen, P. A. J., Saxena, P. R., editor, Wallis, D. I., editor, Wouters, W., editor, and Bevan, P., editor
- Published
- 1990
- Full Text
- View/download PDF
49. The Role of the Endothelium in the Cardiovascular Response to Serotonin
- Author
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Vanhoutte, P. M., Van Nueten, J. M., Janssens, W. J., Paoletti, Rodolfo, editor, Vanhoutte, Paul M., editor, Brunello, Nicoletta, editor, and Maggi, Franco M., editor
- Published
- 1990
- Full Text
- View/download PDF
50. Amplifying Effect of Serotonin in the Control of Vascular Tone
- Author
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Janssens, W. J., Van Nueten, J. M., Paoletti, Rodolfo, editor, Vanhoutte, Paul M., editor, Brunello, Nicoletta, editor, and Maggi, Franco M., editor
- Published
- 1990
- Full Text
- View/download PDF
Catalog
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