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2. Grey wolf genomic history reveals a dual ancestry of dogs

Author

Bergström, Anders, Stanton, David WG, Taron, Ulrike H, Frantz, Laurent, Sinding, Mikkel-Holger S, Ersmark, Erik, Pfrengle, Saskia, Cassatt-Johnstone, Molly, Lebrasseur, Ophélie, Girdland-Flink, Linus, Fernandes, Daniel M, Ollivier, Morgane, Speidel, Leo, Gopalakrishnan, Shyam, Westbury, Michael V, Ramos-Madrigal, Jazmin, Feuerborn, Tatiana R, Reiter, Ella, Gretzinger, Joscha, Münzel, Susanne C, Swali, Pooja, Conard, Nicholas J, Carøe, Christian, Haile, James, Linderholm, Anna, Androsov, Semyon, Barnes, Ian, Baumann, Chris, Benecke, Norbert, Bocherens, Hervé, Brace, Selina, Carden, Ruth F, Drucker, Dorothée G, Fedorov, Sergey, Gasparik, Mihály, Germonpré, Mietje, Grigoriev, Semyon, Groves, Pam, Hertwig, Stefan T, Ivanova, Varvara V, Janssens, Luc, Jennings, Richard P, Kasparov, Aleksei K, Kirillova, Irina V, Kurmaniyazov, Islam, Kuzmin, Yaroslav V, Kosintsev, Pavel A, Lázničková-Galetová, Martina, Leduc, Charlotte, Nikolskiy, Pavel, Nussbaumer, Marc, O’Drisceoil, Cóilín, Orlando, Ludovic, Outram, Alan, Pavlova, Elena Y, Perri, Angela R, Pilot, Małgorzata, Pitulko, Vladimir V, Plotnikov, Valerii V, Protopopov, Albert V, Rehazek, André, Sablin, Mikhail, Seguin-Orlando, Andaine, Storå, Jan, Verjux, Christian, Zaibert, Victor F, Zazula, Grant, Crombé, Philippe, Hansen, Anders J, Willerslev, Eske, Leonard, Jennifer A, Götherström, Anders, Pinhasi, Ron, Schuenemann, Verena J, Hofreiter, Michael, Gilbert, M Thomas P, Shapiro, Beth, Larson, Greger, Krause, Johannes, Dalén, Love, and Skoglund, Pontus

Subjects
Africa, Animals, DNA, Ancient, Dogs, Domestication, Europe, Genome, Genomics, History, Ancient, Middle East, Mutation, North America, Phylogeny, Selection, Genetic, Siberia, Tumor Suppressor Proteins, Wolves, General Science & Technology
Abstract

The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived1-8. Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000-30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located.

Published
2022

3. Movement Smoothness Metrics in Human-Machine Interaction

Author

Antonelli, Mattia, Caselli, Elena, Gastaldi, Laura, Janssens, Luc, Pastorelli, Stefano, Bjerkefors, Anna, Vanlandewijck, Yves, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, Petuya, Victor, editor, Quaglia, Giuseppe, editor, Parikyan, Tigran, editor, and Carbone, Giuseppe, editor

Published
2023
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5. Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment

Author

Sen, Sayan, Ahmad, Yousif, Dehbi, Hakim-Moulay, Howard, James P, Iglesias, Juan F, Al-Lamee, Rasha, Petraco, Ricardo, Nijjer, Sukhjinder, Bhindi, Ravinay, Lehman, Sam, Walters, Darren, Sapontis, James, Janssens, Luc, Vrints, Christiaan J, Khashaba, Ahmed, Laine, Mika, Van Belle, Eric, Krackhardt, Florian, Bojara, Waldemar, Going, Olaf, Härle, Tobias, Indolfi, Ciro, Niccoli, Giampaolo, Ribichini, Flavio, Tanaka, Nobuhiro, Yokoi, Hiroyoshi, Takashima, Hiroaki, Kikuta, Yuetsu, Erglis, Andrejs, Vinhas, Hugo, Silva, Pedro Canas, Baptista, Sérgio B, Alghamdi, Ali, Hellig, Farrel, Koo, Bon-Kwon, Nam, Chang-Wook, Shin, Eun-Seok, Doh, Joon-Hyung, Brugaletta, Salvatore, Alegria-Barrero, Eduardo, Meuwissen, Martijin, Piek, Jan J, van Royen, Niels, Sezer, Murat, Di Mario, Carlo, Gerber, Robert T, Malik, Iqbal S, Sharp, Andrew SP, Talwar, Suneel, Tang, Kare, Samady, Habib, Altman, John, Seto, Arnold H, Singh, Jasvindar, Jeremias, Allen, Matsuo, Hitoshi, Kharbanda, Rajesh K, Patel, Manesh R, Serruys, Patrick, Escaned, Javier, and Davies, Justin E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Heart Disease - Coronary Heart Disease, Heart Disease, Clinical Research, Cardiovascular, Good Health and Well Being, Aged, Coronary Angiography, Coronary Stenosis, Coronary Vessels, Female, Fractional Flow Reserve, Myocardial, Humans, Male, Middle Aged, Myocardial Revascularization, coronary stenosis, fractional flow reserve, instantaneous wave-free ratio, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundPhysicians are not always comfortable deferring treatment of a stenosis in the left anterior descending (LAD) artery because of the perception that there is a high risk of major adverse cardiac events (MACE). The authors describe, using the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) trial, MACE rates when LAD lesions are deferred, guided by physiological assessment using fractional flow reserve (FFR) or the instantaneous wave-free ratio (iFR).ObjectivesThe purpose of this study was to establish the safety of deferring treatment in the LAD using FFR or iFR within the DEFINE-FLAIR trial.MethodsMACE rates at 1 year were compared between groups (iFR and FFR) in patients whose physiological assessment led to LAD lesions being deferred. MACE was defined as a composite of cardiovascular death, myocardial infarction (MI), and unplanned revascularization at 1 year. Patients, and staff performing follow-up, were blinded to whether the decision was made with FFR or iFR. Outcomes were adjusted for age and sex.ResultsA total of 872 patients had lesions deferred in the LAD (421 guided by FFR, 451 guided by iFR). The event rate with iFR was significantly lower than with FFR (2.44% vs. 5.26%; adjusted HR: 0.46; 95% confidence interval [CI]: 0.22 to 0.95; p = 0.04). This was driven by significantly lower unplanned revascularization with iFR and numerically lower MI (unplanned revascularization: 2.22% iFR vs. 4.99% FFR; adjusted HR: 0.44; 95% CI: 0.21 to 0.93; p = 0.03; MI: 0.44% iFR vs. 2.14% FFR; adjusted HR: 0.23; 95% CI: 0.05 to 1.07; p = 0.06).ConclusionsiFR-guided deferral appears to be safe for patients with LAD lesions. Patients in whom iFR-guided deferral was performed had statistically significantly lower event rates than those with FFR-guided deferral.

Published
2019

6. Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

Author

Auer, Johann, Hubauer, Martin, Pandzic, Sead, Preishuber, Eva, Primus-Grabscheit, Carina, Reitgruber, Dietmar, Schmalzer, Florian, Adlbrecht, Christopher, Schober, Andreas, Hajos, Johannes, Keil, Christoph, Schratter, Alexandra, Frick, Matthias, Benda, Magdalena Anna, Mächler, Maximilian, Mutschlechner, Beatrix, Saely, Christoph, Sprenger, Lukas, Lichtenauer, Michael, Eber, Miriam, Hoppe, Uta, Kolbitsch, Tobias, Jirak, Peter Michael, Mirna, Moritz, Schönbauer, Robert, Bergler-Klein, Jutta, Hengstenberg, Christian, Stojkovic, Stefan, Scherr, Daniel, Manninger-Wünscher, Martin, Rohrer, Ursula, Stühlinger, Markus, Schgoer, Wilfried, Schwarzl, Jana, Pürerfellner, Helmut, Derndorfer, Michael, Ebner, Christian, Eder, Veronika, Kollias, Georgios, Sturmberger, Thomas, Sieghartsleitner, Stefan, Vijgen, Johan, Koopman, Peter, Dujardin, Karl, Anné, Wim, De Ceuninck, Michel, Tavernier, Rene, Duytschaever, Mattias, Knecht, Sébastien, Missault, Luc, Vandekerckhove, Yves, Rossenbacker, Tom, Ector, Bavo, Charlier, Filip, Debruyne, Philippe, Dewilde, Willem, Janssens, Luc, Roosen, John, Vankelecom, Bart, Heidbuchel, Hein, Delesie, Michiel, Vervoort, Gert, Rombouts, Hans, Vanassche, Thomas, Engelen, Matthias, Verhamme, Peter, Willems, Rik, Constance, Christian, Pranno, Nicolas, Cox, Jafna, Bata, Iqbal, Macle, Laurent, Aguilar, Martin, Tourigny, Julia Cadrin, Dubuc, Marc, Dyrda, Katia, Guerra, Peter, Khairy, Paul, Mondésert, Blandine, Rivard, Léna, Roy, Denis, Tadros, Rafik, Talajic, Mario, Thibault, Bernard, Nault, Isabelle, Blier, Louis, Champagne, Jean, Molin, Franck, O'Hara, Gilles, Philippon, François, Plourde, Benoit, Sarrazin, Jean-François, Steinberg, Christian, Coufal, Zdenek, Balazsik, David, Mikulica, Michal, Zapeca, Jakub, Cermak, Ondrej, Drasnar, Tomas, Falc, Matej, Hornof, Josef, Racz, Blazej, Weissova, Danica, Linkova, Hana, Paskova, Eva, Petr, Robert, Sirakova, Andrea, Kettner, Jiri, Benak, Ales, Holek, Martin, Podpera, Ivo, Podperova, Monika, Vancura, Vlastimil, Jandik, Tomas, Smid, Jiri, Dedek, Vratislav, Banik, Jan, Durdil, Vaclav, Hnat, Tomas, Lellouche, Nicolas, Rouffiac, Ségolène, Taldir, Guillaume, Bridonneau, Valentin, Couffon, Philippe, Daudin, Magalie, Hamon, Cécile, Lacaze, Jonathan, Quentin, Anne, Thebault, Christophe, Boiffard, Emmanuel, Billon, Olivier, Miette, Fabien, Pouliquen, Hervé, Turlotte, Guillaume, Gorka, Hervé, Albert, Franck, Bayle, Sandrine, Bensaid, Reda, Dasoveanu, Madalina, Demichili, Thibaud, Dutoiu, Teodora, Khalil, Cliff, Loghin, Caterina, Range, Grégoire, Roussel, Laurent, Socié, Pierre, Thuaire, Christophe, Extramiana, Fabrice, Algalarrondo, Vincent, Boughanmi, Haten, El Mansour, Noreddine, Mohammad, Usman, Sellier, Romain, Elbaz, Meyer, Laperche, Clémence, Maury, Philippe, Kiss, Robert, Borsanyi, Tunde, Gingl, Zoltan, Polgar, Balaza, Benczur, Bela, Bodor, Alexandra, Hepp, Tamas, Malati, Eva, Nagy, Laszlo, Erdei, Norbert, Kapus, Jozsef, Kapus, Katalin, Toth, Brigitta, Matoltsy, Andras, Kiss, Tunde, Merkely, Bela, Herczeg, Szilvia, Kiss, Orsolya, Sallo, Zoltan, Toth, Kalman, Habon, Tamas, Rabai, Miklos, Totsimon, Kinga, Zilahi, Zsolt, Bencze, Gabriella, Santa, Janos, Aradi, Daniel, Kelemen, Barbara, Bolognese, Leonardo, Nesti, Martina, Notarstefano, Pasquale Giovanni, D'Orazio, Simona, Cosmi, Franco, Becattini, Cecilia, Agnelli, Giancarlo, Broccatelli, Belinda, Mosconi, Maria Giulia, Paciaroni, Maurizio, Urbini, Chiara, Parato, Vito Maurizio, Notaristefani, Camilla, Scarano, Michele, Ameri, Pietro, Ghigliotti, Giorgio, Guglielmi, Giulia, Lotti, Roberta, Merlo, Andrea Carlo, Muiesan, Maria Lorenza, Abondio, Andrea, Berasi, Caterina, Mattiuzzo, Elena, Mutti, Claudio, Salvetti, Massimo, Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Tamiya, Eiji, Matsumoto, Takahiro, Takabe, Tomosato, Yamamoto, Shoichi, Yamashita, Haruyo, Higashiue, Shinichi, Furuya, Onichi, Hiramatsu, Norihiko, Kasuga, Kensuke, Kojima, Saburo, Komooka, Masatoshi, Kuroyanagi, Satoshi, Matsuura, Makoto, Takemoto, Tetsushi, Yamamoto, Shuji, Saito, Katusmi, Abe, Takuro, Ishida, Issei, Iwanami, Yuji, Kataoka, Shohei, Moriyama, Tetsu, Murohashi, Akira, Sasaki, Akihito, Nakamura, Yuichiro, Ueno, Tetsuya, Shimane, Akira, Hamana, Tomoyo, Ichibori, Hirotoshi, Inoue, Tomohiro, Itoh, Mitsuaki, Iwane, Seigo, Kawai, Hiroya, Kokawa, Tatsuya, Masumoto, Akiko, Matsuo, Koki, Miyata, Taishi, Nakano, Shinsuke, Oishi, Shogo, Onishi, Tetsuari, Sawada, Takahiro, Saito, Takayuki, Shoda, Mitsuhiko, Takahashi, Nobuyuki, Takaya, Tomofumi, Taniguchi, Yasuyo, Tsukamoto, Shota, Tsukishiro, Yasue, Tsukiyama, Yoshiro, Tsunamoto, Hiroshi, Uzu, Kenzo, Yamamoto, Hiroyuki, Yamamoto, Tetsuya, Yokoi, Kiminobu, Yoshida, Chiaki, Watanabe, Nobuhiro, Betsuyaku, Tetsuo, Adachi, Kumiko, Awane, Kouichi, Goto, Daisuke, Sakakibara, Mamoru, Watanabe, Masashi, Ueno, Hideki, Hiroe, Yoshitaka, Matsuo, Koshi, Ayata, Kenji, Fukuda, Ko, Hata, Yoshiki, Hashimoto, Katsushi, Matsumi, Hiroaki, Nikaido, Akira, Okamoto, Shuichi, Sime, Iveta, Stirna, Valters, Reinholde, Ilze, Hansone, Silvija, Kozlovska, Anita, Romanova, Janina, Klincare, Dace, Pontaga, Natalja, Dirmans, Igors, Kalnins, Artis, Upite, Dana, Gersamija, Arcils, Teleznikovs, Arturs, Rozkova, Nadezda, Safro, Jelena, Anguera Camós, Ignasi, Domenico Dallaglio, Paolo, Salguero Bodes, Rafael, Arnbas, Fernando, Borrego, Luis, Marco, Alvaro, Jimenez, Javier Ramos, Gómez-Doblas, Juan José, Pérez Cabeza, Alejandro, Ferreira Gonzålez, Ignacio, Limeres Freire, Javier, Lopez Grau, Merce, Viñolas Prat, Xavier, Moreno Weidmann, Zoraida, Guerra Ramos, Jose Maria, Alonso Martin, Maria Concepcion, Campos Garcia, Bieito, Mogro Carranza, Javier Mauricio, Mendez Zurita, Francisco Javier, Rodriguez Font, Enrique, Gonzales Matos, Carlos Eduardo, García Hernando, Víctor, Lindholm, Carl-Johan, Thulin, Jörgen, Wallén, Håkan, Hagwall, Kristina, Eliasson, Ken, Lundvall, Martin, Olsson, Jens, Kjellman, Björn, Lind, Markus, Johansson, Lars, Svedberg, Niclas, Berglund, Stefan, Söderberg, Julia, Zedigh, Christer, Mooe, Thomas, Axelsson, Mattias, Binsell, Emil, Huber, Daniel, Müller, Christian, Danier, Isabelle, Kühne, Michael, Okamura, Bernhard, Schoepfer, Hadrien, Simmen, Cornelia, Reichlin, Tobias, Chollet, Laurève, Lam, Anna, Wittmer, Severin, Rickli, Hans, Gall, Christian, Hametner, Greta, Intorp, Stephanie, Luescher, Daniel, Haegeli, Laurent, Berg, Jan Christopher, Ebrahimi, Ramin, Auricchio, Angelo, Crljenica, Carmela, Moccetti, Tizziano, Monti, Cristina, Pasotti, Elena, Petrova, Iveta, Rossi, Mariagrazia, Mach, François, Namdar, Mehdi, de Groot, Joris, Proost, Virginnio, Neefs, Joline, Linz, Dominik, van Stipdonk, Twan, den Uijl, Dennis, Alings, Marco, Schaap, Jeroen, Segers, Dolf, Wouters, Noemi, Bartels, Louis, Tieleman, Robert, Pisters, Ron, de Vries, Tim, Selig, Jaap, Kuijper, Aaf, Bot, Pieter, Keijzers, Mitran, Verdel, Gerardus, Tukkie, Raymond, van den Bos, Ewout, Kauer, Floris, Oemrawsingh, Rohit, Stevenhagen, Jeroen, van Es, Jan, Lip, Gregory, Gupta, Dhiraj, Kotalczyk, Agnieszka, Gunstone, Anthony, Brixey, Richard David, Gorog, Diana, Dinarvand, Danial, Gue, Ying, Kanji, Rahim, Memtsas, Vassilios, Senior, Roxy, Bioh, Gabriel, Wong, Yuk-Ki, Child, Nick, Piccini, Jonathan P, Caso, Valeria, Connolly, Stuart J, Fox, Keith A A, Oldgren, Jonas, Jones, W Schuyler, Gorog, Diana A, Durdil, Václav, Viethen, Thomas, Neumann, Christoph, Mundl, Hardi, and Patel, Manesh R

Published
2022
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7. Angiography-derived physiology guidance vs usual care in an All-comers PCI population treated with the healing-targeted supreme stent and Ticagrelor monotherapy: PIONEER IV trial design

Author

Hara, Hironori, Serruys, Patrick W., O'Leary, Neil, Gao, Chao, Murray, Alicia, Breslin, Elaine, Garg, Scot, Bureau, Christophe, Reiber, Johan HC, Barbato, Emanuele, Aminian, Adel, Janssens, Luc, Rosseel, Liesbeth, Benit, Edouard, Campo, Gianluca, Guiducci, Vincenzo, Casella, Gianni, Santarelli, Andrea, Franzè, Alfonso, Diaz, Victor Alfonso Jimenez, Iñiguez, Andrés, Brugaletta, Salvatore, Sabate, Manel, Amat-Santos, Ignacio J., Amoroso, Giovanni, Wykrzykowska, Joanna, von Birgelen, Clemens, Somi, Samer, Liu, Tommy, Hofma, Sjoerd H., Curzen, Nick, Trillo, Ramiro, Ocaranza, Raymundo, Mathur, Anthony, Smits, Pieter C., Escaned, Javier, Baumbach, Andreas, Wijns, William, Sharif, Faisal, and Onuma, Yoshinobu

Published
2022
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8. Cognitive Development and Decision Making in Basketball: A Comparison between Male Players with and without Intellectual Impairment and across Different Age-Groups.

Author

Pinilla-Arbex, Javier, Pérez-Tejero, Javier, Van Biesen, Debbie, Polo, Ignacio, Janssens, Luc, and Vanlandewijck, Yves

Subjects
BASKETBALL players, TEAM sports, DISCRIMINANT analysis, DECISION making, COGNITIVE development
Abstract

The aim of this study was to investigate the role of age and intellectual impairment (II) in decision-making in basketball. The current study investigated differences in decision making between equally well-trained adult basketball male players with intellectual impairment (players with II) (n = 93), adults without II (senior) (n = 44) and youth basketball players (under-14, n = 31; under-16, n = 25; under-18, n = 30). A computer test was developed composed by 20 photographs displaying various basketball game-situations, and participants had to decide as fast as possible what the player in ball possession should do: dribble, pass or shoot. Decision time and accuracy were recorded for every situation. Players with II had slower decision time (3.8 ± 1.8 s vs. 1.5 ± 0.5 s, p < 0.001) and less decision-making accuracy (15.7 ± 2.8 correct decisions vs. 17.9 ± 1.2 correct decisions, p < 0.001) compared to senior players without II. Discriminant analysis with speed and accuracy as independent variables classified 91.2% (CCA = 0.769) of the players correctly into their group: players with II or players without II. A Spearman correlation revealed that age correlated significantly (p < 0.001) with the number of correct decisions (rs = 0.269) and mean decision time (rs = -0.331). Our findings support that decision making in basketball develops with age and experience, but is significantly deteriorated in experienced adult players who have II. Decision-making should be considered as an important eligibility criterion to participate in competitive basketball events for male players with II. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Ticagrelor Monotherapy Versus Dual-Antiplatelet Therapy After PCI: An Individual Patient-Level Meta-Analysis

Author

Valgimigli, Marco, Mehran, Roxana, Windecker, Stephan, Vranckx, Pascal, Serruys, Patrick, Steg, Gabriel P., Hamm, Christian, Baber, Usman, Angiolillo, Dominick J., Cohen, David J., Dangas, George D., Mehta, Shamir, Gibson, Michael C., Kastrati, Adnan, Krucoff, Mitchel, Ohman, Magnus E., Gurbel, Paul, Henry, Timothy D., Moliterno, David, Sharma, Samin K., Pocock, Stuart, Jüni, Peter, da Costa, Bruno R., Kirkham, Brian, Sartori, Samantha, Heg, Dierik, McFadden, Eugene, Leonardi, Sergio, Piccolo, Raffaele, Franzone, Anna, Marx, Steven O., Darrow, Bruce, Corvaja, Nicola, DeStefano, Douglas, Ghodsi, Newsha, Meller, Jose, Franklin-Bond, Theresa, Cha, Jin Young, Waseem, Zaha, Huber, Kurt, Weisz, Giora, Kornowski, Ran, Kunadian, Vijay, Oldroyd, Keith, Yaling, Han, Kaul, Upendra, Witzenbichler, Bernhard, Dzavik, Vladimir, Gil, Robert, Dudek, Dariuz, Sardella, Gennaro, Escaned, Javier, Shlofmitz, Richard, Briguori, Carlo, Benit, Edouard, Liebetrau, Christoph, Janssens, Luc, Ferrario, Maurizio, Zurakowski, Aleksander, Diletti, Roberto, Dominici, Marcello, Slagboom, Ton, Buszman, Paweł, Bolognese, Leonardo, Tumscitz, Carlo, Bryniarski, Krzysztof, Aminian, Adel, Vrolix, Mathias, Petrov, Ivo, Garg, Scot, Naber, Christoph, Prokopczuk, Janusz, Steg, Philippe Gabriel, McFadden, Eùgene P., Cao, Davide, Mehta, Shamir R., Serruys, Patrick W., Gibson, C. Michael, Oldroyd, Keith G., and Heg, Dik

Published
2021
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11. Cognitive Development and Decision Making in Basketball : A Comparison between Male Players with and without Intellectual Impairment and across Different Age-Groups

Author

Pinilla Arbex, Javier, Pérez-Tejero, Javier, Van Biesen, Debbie, Polo, Ignacio, Janssens, Luc, Vanlandewijck, Yves, Pinilla Arbex, Javier, Pérez-Tejero, Javier, Van Biesen, Debbie, Polo, Ignacio, Janssens, Luc, and Vanlandewijck, Yves

Abstract

The aim of this study was to investigate the role of age and intellectual impairment (II) in decision-making in basketball. The current study investigated differences in decision making between equally well-trained adult basketball male players with intellectual impairment (players with II) (n = 93), adults without II (senior) (n = 44) and youth basketball players (under-14, n = 31; under-16, n = 25; under-18, n = 30). A computer test was developed composed by 20 photographs displaying various basketball game-situations, and participants had to decide as fast as possible what the player in ball possession should do: dribble, pass or shoot. Decision time and accuracy were recorded for every situation. Players with II had slower decision time (3.8 ± 1.8 s vs. 1.5 ± 0.5 s, p < 0.001) and less decision-making accuracy (15.7 ± 2.8 correct decisions vs. 17.9 ± 1.2 correct decisions, p < 0.001) compared to senior players without II. Discriminant analysis with speed and accuracy as independent variables classified 91.2% (CCA = 0.769) of the players correctly into their group: players with II or players without II. A Spearman correlation revealed that age correlated significantly (p < 0.001) with the number of correct decisions (rs = 0.269) and mean decision time (rs = −0.331). Our findings support that decision making in basketball develops with age and experience, but is significantly deteriorated in experienced adult players who have II. Decision-making should be considered as an important eligibility criterion to participate in competitive basketball events for male players with II.

Published
2024
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13. Impact of recruitment and retention on all-cause mortality in a large all-comers randomised controlled trial: insights from the GLOBAL LEADERS trial

Author

Takahashi, Kuniaki, Kogame, Norihiro, Tomaniak, Mariusz, Chichareon, Ply, Chang, Chun-Chin, Modolo, Rodrigo, Benit, Edouard, Liebetrau, Christoph, Janssens, Luc, Ferrario, Maurizio, Zurakowski, Aleksander, van Geuns, Robert Jan, Dominici, Marcello, Huber, Kurt, Buszman, Pawel, Bolognese, Leonardo, Tumscitz, Carlo, Żmudka, Krzysztof, Aminian, Adel, Vrolix, Mathias, Petrov, Ivo, Wykrzykowska, Joanna J., de Winter, Robbert J., Hamm, Christian, Steg, Philippe Gabriel, Onuma, Yoshinobu, Valgimigli, Marco, Windecker, Stephan, Vranckx, Pascal, Garg, Scot, and Serruys, Patrick W.

Published
2020
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14. Ticagrelor Alone Versus Dual Antiplatelet Therapy From 1 Month After Drug-Eluting Coronary Stenting

Author

Franzone, Anna, McFadden, Eugène, Leonardi, Sergio, Piccolo, Raffaele, Vranckx, Pascal, Serruys, Patrick W., Benit, Edouard, Liebetrau, Christoph, Janssens, Luc, Ferrario, Maurizio, Zurakowski, Aleksander, Diletti, Roberto, Dominici, Marcello, Huber, Kurt, Slagboom, Ton, Buszman, Paweł, Bolognese, Leonardo, Tumscitz, Carlo, Bryniarski, Krzysztof, Aminian, Adel, Vrolix, Mathias, Petrov, Ivo, Garg, Scot, Naber, Christoph, Prokopczuk, Janusz, Hamm, Christian, Steg, Philippe Gabriel, Heg, Dik, Jüni, Peter, Windecker, Stephan, and Valgimigli, Marco

Published
2019
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15. Sex Differences in Instantaneous Wave-Free Ratio or Fractional Flow Reserve–Guided Revascularization Strategy

Author

Kim, Chee Hae, Koo, Bon-Kwon, Dehbi, Hakim-Moulay, Lee, Joo Myung, Doh, Joon-Hyung, Nam, Chang-Wook, Shin, Eun-Seok, Cook, Christopher M., Al-Lamee, Rasha, Petraco, Ricardo, Sen, Sayan, Malik, Iqbal S., Nijjer, Sukhjinder S., Mejía-Rentería, Hernán, Alegria-Barrero, Eduardo, Alghamdi, Ali, Altman, John, Baptista, Sérgio B., Bhindi, Ravinay, Bojara, Waldemar, Brugaletta, Salvatore, Silva, Pedro Canas, Di Mario, Carlo, Erglis, Andrejs, Gerber, Robert T., Going, Olaf, Härle, Tobias, Hellig, Farrel, Indolfi, Ciro, Janssens, Luc, Jeremias, Allen, Kharbanda, Rajesh K., Khashaba, Ahmed, Kikuta, Yuetsu, Krackhardt, Florian, Laine, Mika, Lehman, Sam J., Matsuo, Hitoshi, Meuwissen, Martijin, Niccoli, Giampaolo, Piek, Jan J., Ribichini, Flavo, Samady, Habib, Sapontis, James, Seto, Arnold H., Sezer, Murat, Sharp, Andrew S.P., Singh, Jasvindar, Takashima, Hiroaki, Talwar, Suneel, Tanaka, Nobuhiro, Tang, Kare, Van Belle, Eric, van Royen, Niels, Vinhas, Hugo, Vrints, Christiaan J., Walters, Darren, Yokoi, Hiroyoshi, Samuels, Bruce, Buller, Christopher, Patel, Manesh R., Serruys, Patrick W., Escaned, Javier, and Davies, Justin E.

Published
2019
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16. 2-Year Clinical Outcomes of an Abluminal Groove–Filled Biodegradable-Polymer Sirolimus-Eluting Stent Compared With a Durable-Polymer Everolimus-Eluting Stent

Author

Xu, Bo, Saito, Yuichi, Baumbach, Andreas, Kelbæk, Henning, van Royen, Niels, Zheng, Ming, Morel, Marie-Angèle, Knaapen, Paul, Slagboom, Ton, Johnson, Thomas W., Vlachojannis, Georgios, Arkenbout, Karin E., Holmvang, Lene, Janssens, Luc, Ochala, Andrzej, Brugaletta, Salvatore, Naber, Christoph K., Anderson, Richard, Rittger, Harald, Berti, Sergio, Barbato, Emanuele, Toth, Gabor G., Maillard, Luc, Valina, Christian, Buszman, Paweł, Thiele, Holge, Schächinger, Volker, Lansky, Alexandra, and Wijns, William

Published
2019
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19. Inspiratory muscle training for dyspnea management in people with unilateral diaphragm dysfunction

Author

Schaeffer, Michele, primary, Louvaris, Zafeiris, additional, Rodrigues, Antenor, additional, Poddighe, Diego, additional, Gayan-Ramirez, Ghislaine, additional, Gojevic, Tin, additional, Geerts, Linde, additional, Heyndrickx, Elise, additional, Van Hollebeke, Marine, additional, Janssens, Luc, additional, Gosselink, Rik, additional, Testelmans, Dries, additional, and Langer, Daniel, additional

Published
2023
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20. Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes

Author

Escaned, Javier, Ryan, Nicola, Mejía-Rentería, Hernán, Cook, Christopher M., Dehbi, Hakim-Moulay, Alegria-Barrero, Eduardo, Alghamdi, Ali, Al-Lamee, Rasha, Altman, John, Ambrosia, Alphonse, Baptista, Sérgio B., Bertilsson, Maria, Bhindi, Ravinay, Birgander, Mats, Bojara, Waldemar, Brugaletta, Salvatore, Buller, Christopher, Calais, Fredrik, Silva, Pedro Canas, Carlsson, Jörg, Christiansen, Evald H., Danielewicz, Mikael, Di Mario, Carlo, Doh, Joon-Hyung, Erglis, Andrejs, Erlinge, David, Gerber, Robert T., Going, Olaf, Gudmundsdottir, Ingibjörg, Härle, Tobias, Hauer, Dario, Hellig, Farrel, Indolfi, Ciro, Jakobsen, Lars, Janssens, Luc, Jensen, Jens, Jeremias, Allen, Kåregren, Amra, Karlsson, Ann-Charlotte, Kharbanda, Rajesh K., Khashaba, Ahmed, Kikuta, Yuetsu, Krackhardt, Florian, Koo, Bon-Kwon, Koul, Sasha, Laine, Mika, Lehman, Sam J., Lindroos, Pontus, Malik, Iqbal S., Maeng, Michael, Matsuo, Hitoshi, Meuwissen, Martijn, Nam, Chang-Wook, Niccoli, Giampaolo, Nijjer, Sukhjinder S., Olsson, Hans, Olsson, Sven-Erik, Omerovic, Elmir, Panayi, Georgios, Petraco, Ricardo, Piek, Jan J., Ribichini, Flavo, Samady, Habib, Samuels, Bruce, Sandhall, Lennart, Sapontis, James, Sen, Sayan, Seto, Arnold H., Sezer, Murat, Sharp, Andrew S.P., Shin, Eun-Seok, Singh, Jasvindar, Takashima, Hiroaki, Talwar, Suneel, Tanaka, Nobuhiro, Tang, Kare, Van Belle, Eric, van Royen, Niels, Varenhorst, Christoph, Vinhas, Hugo, Vrints, Christiaan J., Walters, Darren, Yokoi, Hiroyoshi, Fröbert, Ole, Patel, Manesh R., Serruys, Patrick, Davies, Justin E., and Götberg, Matthias

Published
2018
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21. Pre-Angioplasty Instantaneous Wave-Free Ratio Pullback Predicts Hemodynamic Outcome In Humans With Coronary Artery Disease: Primary Results of the International Multicenter iFR GRADIENT Registry

Author

Kikuta, Yuetsu, Cook, Christopher M., Sharp, Andrew S.P., Salinas, Pablo, Kawase, Yoshiaki, Shiono, Yasutsugu, Giavarini, Alessandra, Nakayama, Masafumi, De Rosa, Salvatore, Sen, Sayan, Nijjer, Sukhjinder S., Al-Lamee, Rasha, Petraco, Ricardo, Malik, Iqbal S., Mikhail, Ghada W., Kaprielian, Raffi R., Wijntjens, Gilbert W.M., Mori, Shinsuke, Hagikura, Arata, Mates, Martin, Mizuno, Atsushi, Hellig, Farrel, Lee, Kelvin, Janssens, Luc, Horie, Kazunori, Mohdnazri, Shah, Herrera, Raul, Krackhardt, Florian, Yamawaki, Masahiro, Davies, John, Takebayashi, Hideo, Keeble, Thomas, Haruta, Seiichi, Ribichini, Flavio, Indolfi, Ciro, Mayet, Jamil, Francis, Darrel P., Piek, Jan J., Di Mario, Carlo, Escaned, Javier, Matsuo, Hitoshi, and Davies, Justin E.

Published
2018
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23. Were foxes really domesticated, and were dogs really beasts of burden, during the Bronze Age in Northeast Spain?: A reply to: Grandal-d’Anglade et al: Dogs and foxes in Early-Middle Bronze Age funerary structures in the northeast of the Iberian Peninsula: human control of canid diet at the sites of Can Roqueta (Barcelona) and Minferri (Lleida). Archaeological and Anthropological Sciences, 2019, https://doi.org/10.1007/s12520-019-00781-z

Author

Janssens, Luc A. A. and Lawler, Dennis F.

Published
2019
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24. A Randomized Controlled Trial Comparing BioMime Sirolimus-Eluting Stent With Everolimus-Eluting Stent: Two-Year Outcomes of the meriT-V Trial

Author

Abizaid, Alexandre, primary, Costa, Ricardo, additional, Kedev, Sasko, additional, Kedhi, Elvin, additional, Talwar, Suneel, additional, Erglis, Andrejs, additional, Hlinomaz, Ota, additional, Masotti, Monica, additional, Fath-Ordoubadi, Farzin, additional, Milewski, Krzysztof, additional, Lemos, Pedro, additional, Botelho, Roberto, additional, Ijsselmuiden, Alexander, additional, Koolen, Jacques, additional, Kala, Petr, additional, Janssens, Luc, additional, and Chandra, Udita, additional

Published
2023
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29. Impact of proton pump inhibitors on efficacy of antiplatelet strategies with ticagrelor or aspirin after percutaneous coronary intervention

Author

Ono, Masafumi, Onuma, Yoshinobu, Kawashima, Hideyuki, Hara, Hironori, Gao, Chao, Wang, Rutao, O'Leary, Neil, Benit, Edouard, Janssens, Luc, Ferrario, Maurizio, Żurakowski, Aleksander, Dominici, Marcello, Huber, Kurt, Buszman, Paweł, Garg, Scot, Wykrzykowska, Joanna J, Piek, Jan J, Jüni, Peter, Hamm, Christian, Windecker, Stephan, Vranckx, Pascal, Deliargyris, Efthymios N, Bhatt, Deepak L, Storey, Robert F, Valgimigli, Marco, Serruys, Patrick W, Graduate School, Cardiology, ACS - Atherosclerosis & ischemic syndromes, ACS - Heart failure & arrhythmias, Ono, Masafumi/0000-0002-3919-5648, Gao, Chao/0000-0002-0390-8060, and Storey, Robert/0000-0002-6677-6229

Subjects
Ticagrelor, FOCUSED UPDATE, proton pump inhibitor, Myocardial Infarction, 610 Medicine & health, THERAPY, DEFINITIONS, Humans, Radiology, Nuclear Medicine and imaging, ticagrelor monotherapy, RISK, OUTCOMES, drug interaction, Aspirin, OMEPRAZOLE, percutaneous coronary intervention, Proton Pump Inhibitors, General Medicine, dual antiplatelet therapy, Treatment Outcome, CLOPIDOGREL, PLATELET INHIBITION, Cardiology and Cardiovascular Medicine, 610 Medizin und Gesundheit, Platelet Aggregation Inhibitors, CLINICAL-TRIALS
Abstract

Background Several studies have suggested that proton pump inhibitors (PPIs) may reduce the antiplatelet effects of clopidogrel and/or aspirin, possibly leading to cardiovascular events. Aims We aimed to investigate the association between PPI and clinical outcomes in patients treated with ticagrelor monotherapy or conventional antiplatelet therapy after percutaneous coronary intervention (PCI). Methods This is a subanalysis of the randomized GLOBAL LEADERS trial, comparing the experimental antiplatelet arm (23-month ticagrelor monotherapy following 1-month dual antiplatelet therapy [DAPT]) with the reference arm (12-month aspirin monotherapy following 12-month DAPT) after PCI. Patient-oriented composite endpoints (POCEs: all-cause mortality, myocardial infarction, stroke, or repeat revascularization) and its components were assessed stratified by PPI use as a time-dependent covariate in patients with the experiment or reference antiplatelet arm. Results Among 15,839 patients, 2115 patients (13.5%) experienced POCE at 2 years. In the reference arm, the use of PPIs was independently associated with POCE (hazard ratio [HR]: 1.27; 95% confidence interval [CI]: 1.12-1.44) and its individual components, whereas it was not in the experimental arm (HR: 1.04; 95% CI: 0.92-1.19; p(interaction) = 0.035). During the second-year follow-up, patients taking aspirin with PPIs had a significantly higher risk of POCE compared to those on aspirin without PPIs (HR: 1.57; 95% CI: 1.27-1.94), whereas the risk did not differ significantly irrespective of PPI in ticagrelor monotherapy group (HR: 1.03; 95% CI: 0.83-1.28; p(interaction) = 0.008). Conclusions In contrast to conventional antiplatelet strategy, there were no evidence suggesting the interaction between ticagrelor monotherapy and PPIs on increased cardiovascular events, which should be confirmed in further studies. Clinical Trial Registration URL: The GLOBAL LEADERS trial was supported by unrestricted grants from AstraZeneca, Biosensors, and The Medicines Company. ECRI (European Cardiovascular Research Institute) was formally the sponsor of the study. GLOBAL LEADERS was sponsored by the European Clinical Research Institute, which received funding from Biosensors International, AstraZeneca, and the Medicines Company. P. J. is a Tier 1 Canada Research Chair in Clinical Epidemiology of Chronic Diseases. This study was completed, in part, with funding from the Canada Research Chairs Program. Open access funding provided by IReL.

Published
2022

37. A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction

Author

Rao, Sunil V., primary, Kirsch, Bodo, additional, Bhatt, Deepak L., additional, Budaj, Andrzej, additional, Coppolecchia, Rosa, additional, Eikelboom, John, additional, James, Stefan K., additional, Jones, W. Schuyler, additional, Merkely, Bela, additional, Keller, Lars, additional, Hermanides, Renicus S., additional, Campo, Gianluca, additional, Ferreiro, José Luis, additional, Shibasaki, Taro, additional, Mundl, Hardi, additional, Alexander, John H., additional, Hengstenberg, Christian, additional, Steinwender, Clemens, additional, Alber, Hannes, additional, Steringer-Mascherbauer, Regina, additional, Schober, Andreas, additional, Auer, Johann, additional, Roithinger, Franz Xaver, additional, von Lewinski, Dirk, additional, Moertl, Deddo, additional, Huber, Kurt, additional, Coussement, Patrick, additional, Hoffer, Etienne, additional, Beauloye, Christophe, additional, Janssens, Luc, additional, Vranckx, Pascal, additional, De Raedt, Herbert, additional, Vanassche, Thomas, additional, Vrolix, Matthias, additional, Rokyta, Richard, additional, Parenica, Jiri, additional, Pelouch, Radek, additional, Motovska, Zuzanna, additional, Alan, David, additional, Kettner, Jiri, additional, Polasek, Rostislav, additional, Cermak, Ondrej, additional, Sedlon, Pavel, additional, Hanis, Jiri, additional, Novak, Martin, additional, Belohlavek, Jan, additional, Horacek, Thomas, additional, Leggewie, Stefan, additional, Wenzel, Philip, additional, vom Dahl, Juergen, additional, Sievers, Burkhard, additional, Pulz, Jan, additional, Schellong, Sebastian, additional, Clemmensen, Peter, additional, Muller-Hennessen, Matthias, additional, Rassaf, Tienush, additional, Falukozi, Jozsef, additional, Ruzsa, Zoltan, additional, Tomcsanyi, Janos, additional, Csanadi, Zoltan, additional, Herczeg, Bela, additional, Koszegi, Zsolt, additional, Vorobcsuk, Andras, additional, Kiss, Robert, additional, Baranyai, Csaba, additional, Dezsi, Csaba, additional, Lupkovics, Geza, additional, Rossini, Roberta, additional, Scherillo, Marino, additional, Sergio Saba, Pier, additional, Calogero Campo, Gianluca, additional, Calo, Leonardo, additional, Nassiacos, Daniele, additional, Quadri, Giorgio, additional, Sciahbasi, Alessandro, additional, Silvio Marenzi, Gian Carlo, additional, Reimers, Bernhard, additional, Perna, Gian Piero, additional, Sacca, Salvatore, additional, Fattore, Luciano, additional, Brunelli, Claudio, additional, Picchi, Andrea, additional, Kuramochi, Takehiko, additional, Kondo, Kazuhisa, additional, Aoyama, Takahiko, additional, Kudoh, Takashi, additional, Yamamoto, Tadashi, additional, Takaya, Tomofumi, additional, Mukai, Yasushi, additional, Fukui, Kazuki, additional, Morioka, Nobuyuki, additional, Ando, Kenji, additional, Yamamuro, Atsushi, additional, Morita, Yasuhiro, additional, Koga, Yasuaki, additional, Watanabe, Tetsuya, additional, Sakamoto, Tomohiro, additional, Maebuchi, Daisuke, additional, Takahashi, Akihiko, additional, Yonetsu, Taishi, additional, Kakuta, Tsunekazu, additional, Nishina, Hidetaka, additional, Oemrawsingh, Rohit, additional, Dorman, Reinhart, additional, Oude Ophius, Ton, additional, Prins, Paco, additional, al Windy, N.Y.Y., additional, Zoet-Nugteren, S.K., additional, Hermanides, Rik, additional, van Eck, Martijn, additional, Scherptong, Roderick, additional, Cornel, J.H., additional, Damman, Peter, additional, Bech, Gerhard, additional, Torquay, R., additional, Kietselaer, Bas, additional, Grzelakowski, Pawel, additional, Krzysztof, Dyrbus, additional, Miekus, Pawel, additional, Przybylski, Andrzej, additional, Zarebinski, Maciej, additional, Balsam, Pawel, additional, Szachniewicz, Joanna, additional, Gierlotka, Marek, additional, Tycinska, Agnieszka, additional, Iniguez Romo, Andres, additional, Fernandez Ortiz, Antonio, additional, Carrasquer Cucarella, Anna, additional, Sanmartin Fernandez, Marcelo, additional, Sionis, Alessandro, additional, Bueno Zamora, Hector, additional, Ferreiro Gutierrez, Jose Luis, additional, Almenar, Luis, additional, Ferreira Gonzalez, Ignacio, additional, Pascual Figal, Domingo A., additional, Almendro Delia, Manuel, additional, Jimenez Fernandez, Miriam, additional, Skeppholm, Mika, additional, Zedigh, Crister, additional, Angeras, Oskar, additional, Lauermann, Jorg, additional, Erlinge, David, additional, Gustafsson, Robin, additional, Mooe, Thomas, additional, Utreras, Alejandro, additional, James, Stefan, additional, Grimfjard, Per, additional, Pedrazzini, Giovanni, additional, Mach, Francois, additional, Fournier, Stephane, additional, Haegeli, Laurent, additional, Beer, Jurg H., additional, Leibundgut, Gregor, additional, Kobza, Richard, additional, Kaiser, Christoph, additional, Kunadian, Vijay, additional, Al-Lamee, Rasha, additional, Gorog, Diana, additional, Khan, Sohail, additional, Trevelyan, Jasper, additional, Toor, Iqbal, additional, Smith, James, additional, Purushottam, Bhaskar, additional, Treasure, Charles, additional, Arena, Frank, additional, Vedere, Amarnath, additional, Henderson, David, additional, Gilani, Syed, additional, Jones, Alonzo, additional, Carrillo-Jimenez, Rodolfo, additional, Gillespie, Eve, additional, Marhefka, Gregary, additional, Wang, David, additional, Olson, Charles, additional, Bloom, Stephen, additional, Iftikhar, Faizan, additional, Brabham, David, additional, McGinty, John, additional, Thompson, Charles, additional, Talano, James, additional, Ginete, Wilson, additional, Williams, Marcus, additional, Masud, Ali, additional, Ariani, Mehrdad, additional, Bitar, Fahed, additional, Wang, Thomas, additional, and Samuelson, Bradley, additional

Published
2022
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38. TCT-164 Targeted Therapy With a Localized Abluminal Groove Low-Dose Sirolimus-Eluting Biodegradable-Polymer Coronary Stent: Subgroup Analysis of 5-Year Outcomes of the TARGET All Comers Randomized Trial

Author

Kelbæk, Henning, primary, Lansky, Alexandra, additional, Xu, Bo, additional, Baumbach, Andreas, additional, van Royen, Niels, additional, Knaapen, Paul, additional, Johnson, Thomas, additional, Smits, Pieter, additional, Vlachojannis, Georgios, additional, Arkenbout, Karin, additional, Holmvang, Lene, additional, Janssens, Luc, additional, Ochala, Andrzej, additional, and Wijns, William, additional

Published
2022
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45. Lipid-lowering therapy and risk-based LDL-C goal attainment in Belgium: DA VINCI observational study.

Author

UCL - SSS/IONS - Institute of NeuroScience, UCL - (SLuc) Service de neurologie, van de Borne, Philippe, Peeters, André, Janssens, Luc, Leone, Attilio, Lemmens, Robin, Verhaegen, Ann, De Meulemeester, Marc, Balthazar, Yohan, Heijmans, Stéphane, Calozet, Yvan, Paquot, Nicolas, Carlier, Stéphane, Hemelsoet, Dimitri, Bray, Sarah, Ray, Kausik K, UCL - SSS/IONS - Institute of NeuroScience, UCL - (SLuc) Service de neurologie, van de Borne, Philippe, Peeters, André, Janssens, Luc, Leone, Attilio, Lemmens, Robin, Verhaegen, Ann, De Meulemeester, Marc, Balthazar, Yohan, Heijmans, Stéphane, Calozet, Yvan, Paquot, Nicolas, Carlier, Stéphane, Hemelsoet, Dimitri, Bray, Sarah, and Ray, Kausik K

Abstract

Cardiovascular disease (CVD) is one of the leading causes of death in Belgium. Current strategies for the prevention and management of CVD focus on reducing low-density lipoprotein cholesterol (LDL-C) levels. This analysis assessed whether LDL-C goals, recommended by the European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines, were being achieved in a Belgian study population. The cross-sectional, observational, DA VINCI study enrolled patients prescribed lipid-lowering therapy (LLT) between 21 June 2017 and 20 November 2018. Data for patients from Belgium were extracted for this country-specific analysis. Primary endpoint was the proportion of patients who achieved 2016 ESC/EAS risk-based LDL-C goals; attainment of 2019 risk-based LDL-C goals was evaluated . Of 497 enrolled patients, 41% were female and mean age was 68 years. Among subjects with an LDL-C measurement on stabilised LLT, moderate-intensity statin monotherapy was the most prescribed LLT regimen (59%). Overall, 63% of patients achieved their risk-based LDL-C goals according to the 2016 ESC/EAS guidelines. Among patients with established ASCVD, risk-based LDL-C goal attainment was higher in patients with peripheral arterial disease (53%) than patients with coronary (37%) and cerebrovascular disease (42%). According to the updated 2019 ESC/EAS guidelines, less than half (41%) of patients achieved their risk-based LDL-C goal. The proportion of primary and secondary prevention patients who achieved 2019 risk-based LDL-C goals was 59% and 18%, respectively. These findings reveal a large gap between the LDL-C goals advocated by the ESC/EAS and the levels achieved in routine clinical practice in Belgium.

Published
2022

46. PRECISE-DAPT score for bleeding risk prediction in patients on dual or single antiplatelet regimens:Insights from the GLOBAL LEADERS and GLASSY

Author

Gragnano, Felice, Heg, Dik, Franzone, Anna, McFadden, Eugène P., Leonardi, Sergio, Piccolo, Raffaele, Vranckx, Pascal, Branca, Mattia, Serruys, Patrick W., Benit, Edouard, Liebetrau, Christoph, Janssens, Luc, Ferrario, Maurizio, Zurakowski, Aleksander, Diletti, Roberto, Dominici, Marcello, Huber, Kurt, Slagboom, Ton, Buszman, Paweł, Bolognese, Leonardo, Tumscitz, Carlo, Bryniarski, Krzysztof, Aminian, Adel, Vrolix, Mathias, Petrov, Ivo, Garg, Scot, Naber, Christoph, Prokopczuk, Janusz, Hamm, Christian, Steg, Philippe Gabriel, Jüni, Peter, Windecker, Stephan, Valgimigli, Marco, Gragnano, Felice, Heg, Dik, Franzone, Anna, McFadden, Eugène P., Leonardi, Sergio, Piccolo, Raffaele, Vranckx, Pascal, Branca, Mattia, Serruys, Patrick W., Benit, Edouard, Liebetrau, Christoph, Janssens, Luc, Ferrario, Maurizio, Zurakowski, Aleksander, Diletti, Roberto, Dominici, Marcello, Huber, Kurt, Slagboom, Ton, Buszman, Paweł, Bolognese, Leonardo, Tumscitz, Carlo, Bryniarski, Krzysztof, Aminian, Adel, Vrolix, Mathias, Petrov, Ivo, Garg, Scot, Naber, Christoph, Prokopczuk, Janusz, Hamm, Christian, Steg, Philippe Gabriel, Jüni, Peter, Windecker, Stephan, and Valgimigli, Marco

Abstract

Aims The five-item PRECISE-DAPT, integrating age, haemoglobin, white-blood-cell count, creatinine clearance, and prior bleeding, predicts bleeding risk in patients on dual antiplatelet therapy (DAPT) after stent implantation. We sought to assess whether the bleeding risk prediction offered by the PRECISE-DAPT remains valid among patients receiving ticagrelor monotherapy from 1 month onwards after coronary stenting instead of standard DAPT and having or not having centrally adjudicated bleeding endpoints. Methods The PRECISE-DAPT was calculated in 14 928 and 7134 patients from GLOBAL LEADERS and GLASSY trials, re- and results spectively. The ability of the score to predict Bleeding Academic Research Consortium 3 or 5 bleeding was assessed and compared among patients on ticagrelor monotherapy (experimental strategy) or standard DAPT (reference strategy) from 1 month after drug-eluting stent implantation. Bleeding endpoints were investigator-reported or centrally adjudicated in GLOBAL LEADERS and GLASSY, respectively. At 2 years, the c-indexes for the score among patients treated with the experimental or reference strategy were 0.67 [95% confidence interval (CI): 0.63-0.71] vs. 0.63 (95% CI: 0.59-0.67) in GLOBAL LEADERS (P = 0.27), and 0.67 (95% CI: 0.61-0.73) vs. 0.66 (95% CI: 0.61-0.72) in GLASSY (P = 0.88). Decision curve analysis showed net benefit using the PRECISE-DAPT to guide bleeding risk assessment under both treatment strategies. Results were consistent between investigator-reported and adjudicated endpoints and using the simplified four-item PRECISE-DAPT. Conclusion The PRECISE-DAPT offers a prediction model that proved similarly effective to predict clinically relevant bleeding among patients on ticagrelor monotherapy from 1 month after coronary stenting compared with standard DAPT and appears to be unaffected by the presence or absence of adjudicated bleeding endpoints.

Published
2022

49. Ticagrelor Monotherapy or Dual Antiplatelet Therapy After Drug‐Eluting Stent Implantation: Per‐Protocol Analysis of the GLOBAL LEADERS Trial

Author

Gragnano, Felice, primary, Zwahlen, Marcel, additional, Vranckx, Pascal, additional, Heg, Dik, additional, Schmidlin, Kurt, additional, Hamm, Christian, additional, Steg, Philippe Gabriel, additional, Gargiulo, Giuseppe, additional, McFadden, Eugene P., additional, Onuma, Yoshinobu, additional, Chichareon, Ply, additional, Benit, Edouard, additional, Möllmann, Helge, additional, Janssens, Luc, additional, Leonardi, Sergio, additional, Zurakowski, Aleksander, additional, Arrivi, Alessio, additional, Van Geuns, Robert Jan, additional, Huber, Kurt, additional, Slagboom, Ton, additional, Calabrò, Paolo, additional, Serruys, Patrick W., additional, Jüni, Peter, additional, Valgimigli, Marco, additional, Windecker, Stephan, additional, Abdellaoui, Mohamed, additional, Adlam, David, additional, Akin, Ibrahim, additional, Gonzalez‐Trevilla, Agustin Albarran, additional, Almeida, Manuel, additional, Neto, Pedro Alves Lemos, additional, Aminian, Adel, additional, Anderson, Richard, additional, Andreae, Rick, additional, Angioi, Michael, additional, Asano, Taku, additional, Barbato, Emanuele, additional, Barlis, Peter, additional, Barraud, Pascal, additional, Bertrand, Olivier, additional, Beygui, Farzin, additional, Bolognese, Leonardo, additional, Botelho, Roberto, additional, Bouwman, Coby, additional, Bressers, Marco, additional, Brunel, Philippe, additional, Buszman, Pawel, additional, Buysschaert, Ian, additional, da Silva, Pedro Canas, additional, Carrie, Didier, additional, Cequier, Angel, additional, Chang, Chun Chin, additional, Chowdhary, Saqib, additional, Collet, Carlos, additional, Colombo, Antonio, additional, Cotton, James, additional, Ferreira, Rui Cruz, additional, Curello, Salvatore, additional, Curzen, Nick, additional, de Bot, Judith, additional, de Vreede, Tone, additional, Karth, Georg Delle, additional, Dijksma, Lynn, additional, Dominici, Marcello, additional, Édes, István, additional, Eeckhout, Eric, additional, Eitel, Ingo, additional, Faluközy, József, additional, Fath‐Ordoubadi, Farzin, additional, Ferrario, Maurizio, additional, Fontos, Geza, additional, Diaz, Jose Francisco, additional, Quintella, Edgard Freitas, additional, Frey, Bernhard, additional, Friedrich, Guy, additional, Galasko, Gavin, additional, Galuszka, Grzegorz, additional, Ribeiro, Vasco Gama, additional, Garg, Scot, additional, Geisler, Tobias, additional, Gelev, Valeri, additional, Ghandilyan, Art, additional, Goicolea, Javier, additional, Gori, Tommaso, additional, Gragnano, Felice, additional, Guimarães, Ana, additional, Haude, Michael, additional, Heijke, Pieter, additional, Antolin, Rosa Ana Hernández, additional, Hildick‐Smith, David, additional, Hillen, Dorien, additional, Hoekman, Ina, additional, Hofma, Sjoerd, additional, Holmvang, Lene, additional, Hoole, Stephen, additional, Horváth, Iván, additional, Hugense, Annemarie, additional, Ibrahim, Karim, additional, Iñiguez, Andres, additional, Isaaz, Karl, additional, Jambrik, Zoltán, additional, Jasionowicz, Pawel, additional, Jonk, Judith, additional, Jung, Werner, additional, Katagiri, Yuki, additional, Kogame, Norihiro, additional, Koh, Tian Hai, additional, Koning, René, additional, Konteva, Mariana, additional, Kőszegi, Zsolt, additional, Krackhardt, Florian, additional, Kreuger, Yvonne, additional, Kukreja, Neville, additional, Ladan, Boudijn, additional, Lantelme, Pierre, additional, Leandro, Sergio, additional, Leibundgut, Gregor, additional, Liebetrau, Christoph, additional, Lindeboom, Wietze, additional, Miguel, Carlos Macaya, additional, Mach, François, additional, Magro, Michael, additional, Maillard, Luc, additional, Manavifar, Negar, additional, Mauri, Laura, additional, McFadden, Eugene, additional, Merkely, Bela, additional, Miyazaki, Yosuke, additional, Młodziankowski, Adam, additional, Moccetti, Tiziano, additional, Modolo, Rodrigo, additional, Möllman, Helge, additional, Morelle, Jean‐François, additional, Moschovitis, Aris, additional, Ottesen, Michael Munndt, additional, Muurling, Martin, additional, Naber, Christoph Kurt, additional, Neumann, Franz‐Josef, additional, Oldroyd, Keith, additional, Ong, Paul, additional, Palsrok, Sanne, additional, Petrov, Ivo, additional, Plante, Sylvain, additional, Prokopczuk, Janusz, additional, Rademaker‐Havinga, Tessa, additional, Raffel, Christopher, additional, Rensing, Benno, additional, Roffi, Marco, additional, Royaards, Kees‐Jan, additional, Sabate, Manel, additional, Schächinger, Volker, additional, Seidler, Tim, additional, Peñaranda, Antonio Serra, additional, Serruys, Patrick, additional, Sikarulidze, Lali, additional, Soliman, Osama I, additional, Sousa, Amanda, additional, Spitzer, Ernest, additional, Stables, Rod, additional, Steg, Gabriel, additional, Steinwender, Clemens, additional, Subkovas, Eduardas, additional, Suryapranata, Harry, additional, Takahashi, Kuniaki, additional, Talwar, Suneel, additional, Teiger, Emmanuel, additional, Weele, Addy Ter, additional, Teurlings, Eva, additional, Thury, Attila, additional, Tijssen, Jan, additional, Tonev, Gincho, additional, Trendafilova‐Lazarova, Diana, additional, Tumscitz, Carlo, additional, Umans, Victor, additional, Ungi, Imre, additional, Valkov, Veselin, additional, van der Harst, Pim, additional, van Geuns, Robert Jan, additional, van Meijeren, Cokky, additional, Vassilev, Dobrin, additional, Velchev, Vasil, additional, Velthuizen, Esther, additional, Verheugt, Freek, additional, Vlcek, Natalia, additional, Dahl, Jürgen Vom, additional, Vrolix, Mathias, additional, Walsh, Simon, additional, Werner, Nikos, additional, Witsenburg, Maarten, additional, Zaman, Azfar, additional, Żmudka, Krzysztof, additional, Zrenner, Bernhard, additional, and Zweiker, Robert, additional

Published
2022
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50. Lipid-lowering therapy and risk-based LDL-C goal attainment in Belgium: DA VINCI observational study

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van de Borne, Philippe, primary, Peeters, André, additional, Janssens, Luc, additional, Leone, Attilio, additional, Lemmens, Robin, additional, Verhaegen, Ann, additional, De Meulemeester, Marc, additional, Balthazar, Yohan, additional, Heijmans, Stéphane, additional, Calozet, Yvan, additional, Paquot, Nicolas, additional, Carlier, Stéphane, additional, Hemelsoet, Dimitri, additional, Bray, Sarah, additional, and Ray, Kausik K., additional

Published
2022
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