3,479 results on '"Janssen, H"'
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2. Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial
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Salluzzi, Marina, Blenkin, Nicole, Dueck, Ashley, Doram, Craig, Zhang, Qiao, Kenney, Carol, Ryckborst, Karla, Bohn, Shelly, Collier, Quentin, Taylor, Frances, Lethebe, B. Cord, Jambula, Anitha, Sage, Kayla, Toussaint, Lana, Save, Supryia, Lee, Jaclyn, Laham, N, Sultan, A.A., Deepak, A., Sitaram, A., Demchuk, Andrew M., Lockey, A., Micielli, A., Wadhwa, A., Arabambi, B., Graham, B., Bogiatzi, Chrysi, Doshi, Darshan, Chakraborty, D., Kim, Diana, Vasquez, D, Singh, D, Tse, Dominic, Harrison, E., Smith, E.E., Teleg, E., Klourfeld, E., Klein, G., Sebastian, I.A., Evans, J, Hegedus, J, Kromm, J, Lin, K, Ignacio, K, Ghavami, Kimia, Ismail, M., Moores, M., Panzini, M.A., Boyko, M., Almekhlafi, M.A., Newcommon, Nancy, Maraj, N., Imoukhuede, O., Volny, O., Stys, Peter, Couillard, Phillipe, Ojha, P., Eswaradass, P., Joundi, Raed, Singh, R., Asuncion, R.M., Muir, R.T., Dey, S., Mansoor, S., Wasyliw, S., Nagendra, S., Hu, Sherry, Althubait, S., Chen, S., Bal, S., Van Gaal, Stephen, Peters, Steven, Ray, Sucharita, Chaturvedi, S., Subramaniam, Suresh, Fu, Vivian, Villaluna, K., Maclean, G., King-Azote, P., Ma, C., Plecash, A., Murphy, C., Gorman, J., Wilson, L., Zhou, L., Benevente, O., Teal, P., Yip, S., Mann, S., Dewar, B., Demetroff, M., Shamloul, R., Beardshaw, R., Roberts, S., Blaquiere, D., Stotts, G., Shamy, M., Bereznyakova, O., Fahed, R., Alesefir, W., Lavoie, Suzy, Hache, A., Collard, K, Mackey, A., Gosselin-Lefebvre, S., Verreault, S., Beauchamp, B., Lambourn, L., Khaw, A., Mai, L., Sposato, L., Bres Bullrich, M., Azarpazhooh, R., Fridman, S., Kapoor, A., Southwell, A., Bardi, E., Fatakdawala, I., Kamra, M, Lopes, K., Popel, N., Norouzi, V., Liu, A., Liddy, A.M., Ghoari, B., Hawkes, C., Enriquez, C.A., Gladstone, D.J., Manosalva Alzate, H.A., Khosravani, H., Hopyan, J.J., Sivakumar, K., Son, M., Boulos, M.I., Hamind, M.A., Swartz, R.H., Murphy, R., Reiter, S., Fitzpatrick, T., Bhandari, V., Good, J., Penn, M., Naylor, M., Frost, S., Cayley, A., Akthar, F., Williams, J., Kalman, L., Crellin, L., Wiegner, R., Singh, R.S., Stewart, T., To, W., Singh, S., Pikula, A., Jaigobin, C., Carpani, F., Silver, F., Janssen, H., Schaafsma, J., del Campo, M., Alskaini, M., Rajendram, P., Fairall, P., Granfield, B., Crawford, D., Jabs, J., White, L., Sivakumar, L., Piquette, L., Nguyen, T., Nomani, A., Wagner, A., Alrohimi, A., Butt, A., D'Souza, A., Gajurel, B., Vekhande, C., Kamble, H., Kalashyan, H., Lloret, M., Benguzzi, M., Arsalan, N., Ishaque, N., Ashayeriahmadabad, R., Samiento, R., Hosseini, S., Kazi, S., Das, S., Sugumar, T., Selchen, D., Kostyrko, P., Muccilli, A., Saposnik, A.G., Vandervelde, C., Ratnayake, K., McMillan, S., Katsanos, A., Shoamanesh, A., Sahlas, D.J., Naidoo, V., Todorov, V., Toma, H., Brar, J., Lee, J., Horton, M., Shand, E., Weatherby, S., Jin, A., Durafourt, B., Jalini, S., Gardner, A., Tyson, C., Junk, E., Foster, K., Bolt, K., Sylvain, N., Maley, S., Urroz, L., Peeling, L., Kelly, M., Whelan, R., Cooley, R., Teitelbaum, J., Boutayeb, A., Moore, A., Cole, E., Waxman, L., Ben-Amor, N., Sanchez, R., Khalil, S., Nehme, A., Legault, C., Tampieri, D., Ehrensperger, E., Vieira, L., Cortes, M., Angle, M., Hannouche, M., Badawy, M., Werner, K., Wieszmuellner, S., Langer, A., Gisold, A., Zach, H., Rommer, P., Macher, S., Blechinger, S., Marik, W., Series, W., Baumgartinger, M., Krebs, S., Koski, J., Eirola, S., Ivanoff, T., Erakanto, A., Kupari, L., Sibolt, G., Panula, J., Tomppo, L., Tiainen, M., Ahlstrom, M., Martinez Majander, N., Suomalainen, O., Raty, S., Levi, C., Kerr, E., Allen, J., Kaauwai, L.P., Belevski, L., Russell, M., Ormond, S., Chew, A., Loiselle, A., Royan, A., Hughes, B., Garcia Esperon, C., Pepper, E., Miteff, F., He, J., Lycett, M., Min, M., Murray, N., Pavey, N., Starling de Barros, R., Gangadharan, S., Dunkerton, S., Waller, S., Canento Sanchez, T., Wellings, T., Edmonds, G., Whittaker, K.A., Ewing, M., Lee, P., Singkang, R., McDonald, A., Dos Santos, A., Shin, C., Jackson, D., Tsoleridis, J., Fisicchia, L., Parsons, N., Shenoy, N., Smith, S., Sharobeam, A., Balabanski, A., Park, A., Williams, C., Pavlin-Premri, D., Rodrigues, E., Alemseged, F., Ng, F., Zhao, H., Beharry, J., Ng, J.L., Williamson, J., Wong, J.Z.W., Li, K., Kwan, M.K., Valente, M., Yassi, N., Yogendrakumar, V., McNamara, B., Buchanan, C., McCarthy, C., Thomas, G., Stephens, K., Chung, M., Chung, M.F., Tang, M., Busch, T., Frost, T., Lee, R., Stuart, N., Pachani, N., Menon, A., Borojevic, B., Linton, C.M., Garcia, G., Callaly, E.P., Dewey, H., Liu, J., Chen, J., Wong, J., Nowak, K., To, K., Lizak, N.S., Bhalala, O., Park, P., Tan, P., Martins, R., Cody, R., Forbes, R., Chen, S.K., Ooi, S., Tu, S., Dang, Y.L., Ling, Z., Cranefield, J., Drew, R., Tan, A., Kurunawai, C., Harvey, J., Mahadevan, J.J., Cagi, L., Palanikumar, L., Chia, L.N., Goh, R., El-Masri, S., Urbi, B., Rapier, C., Berrill, H., McEvoy, H., Dunning, R., Kuriakose, S., Chad, T., Sapaen, V., Sabet, A., Shah, D., Yeow, D., Lilley, K., Ward, K., Mozhy Mahizhnan, M., Tan, M., Lynch, C., Coveney, S., Tobin, K., McCabe, J., Marnane, M., Murphy, S., Large, M., Moynihan, B., Boyle, K., Sanjuan, E., Sanchis, M., Boned, S., Pancorbo, O., Sala, V., Garcia, L., Garcia-Tornel, A., Juega, J., Pagola, J., Santana, K., Requena, M., Muchada, M., Olive, M., Lozano, P.J., Rubiera, M., Deck, M., Rodriguez, N., Gomez, B., Reyes Munoz, F.J., Gomez, A.S., Sanz, A.C., Garcia, E.C., Penacoba, G., Ramos, M.E., de Lera Alfonso, M., Feliu, A, Pardo, L., Ramirez, P., Murillo, A., Lopez Dominguez, D., Rodriguez, J., Terceno Izaga, M., Reina, M., Viturro, S.B., Bojaryn, U., Vera Monge, V.A., Silva Blas, Y., R Siew, R., Agustin, S J, Seet, C., Tianming, T., d'Emden, A., Murray, A., Welch, A., Hatherley, K., Day, N., Smith, W., MacRae, E., Mitchell, E.S., Mahmood, A., Elliot, J., Neilson, S., Biswas, V., Brown, C., Lewis, A., Ashton, A., Werring, D., Perry, R., Muhammad, R., Lee, Y.C., Black, A., Robinson, A., Williams, A., Banaras, A., Cahoy, C., Raingold, G., Marinescu, M., Atang, N., Bason, N., Francia, N., Obarey, S., Feerick, S., Joseph, J., Schulz, U., Irons, R., Benjamin, J., Quinn, L., Jhoots, M., Teal, R., Ford, G., Harston, G., Bains, H., Gbinigie, I., Mathieson, P., Sim, C.H., Hayter, E., Kennedy, K., Binnie, L., Priestley, N., Williams, R., Ghatala, R., Stratton, S., Blight, A., Zhang, L., Davies, A., Duffy, H., Roberts, J., Homer, J., Roberts, K., Dodd, K., Cawley, K., Martin, M., Leason, S., Cotgreave, S., Taylor, T., Nallasivan, A., Haider, S., Chakraborty, T., Webster, T., Gil, A., Martin, B., Joseph, B., Cabrera, C., Jose, D., Man, J., Aquino, J., Sebastian, S., Osterdahl, M., Kwan, M., Matthew, M., Ike, N., Bello, P., Wilding, P., Fuentes, R., Shah, R., Mashate, S., Patel, T., Nwanguma, U., Dave, V., Haber, A., Lee, A., O'Sullivan, A., Drumm, B., Dawson, A.C., Matar, T., Roberts, D., Taylor, E., Rounis, E., El-Masry, A., O'Hare, C., Kalladka, D., Jamil, S., Auger, S., Raha, O., Evans, M., Vonberg, F., Kalam, S., Ali Sheikh, A., Jenkins, I.H., George, J., Kwan, J., Blagojevic, J., Saeed, M., Haji-Coll, M., Tsuda, M., Sayed, M., Winterkron, N., Thanbirajah, N., Vittay, O., Karim, R., Smail, R.C., Gauhar, S., Elmamoun, S., Malani, S., Pralhad Kelavkar, S., Hiden, J., Ferdinand, P., Sanyal, R., Varquez, R., Smith, B., Okechukwu, C., Fox, E., Collins, E., Courtney, K., Tauro, S., Patterson, C., McShane, D., Roberts, G., McIImoyle, J., McGuire, K., Fearon, P., Gordon, P., Isaacs, K., Lucas, K., Smith, L., Dews, L., Bates, M., Lawrence, S., Heeley, S., Patel, V., Chin, Y.M., Sims, D., Littleton, E., Khaira, J., Nadar, K., Kieliszkowska, A., Sari, B., Domingos Belo, C., Smith, E., Manolo, E.Y., Aeron-Thomas, J., Doheny, M., Garcia Pardo, M., Recaman, M., Tibajia, M.C., Aissa, M., Mah, Y., Yu, T., Meenakshisundaram, S., Heller, S., Alsukhni, R., Williams, O., Farag, M., Benger, M., Engineer, A., Bayhonan, S., Conway, S., Bhalla, A., Nouvakis, D., Theochari, E., Boyle, F., Teo, J., King-Robson, J., Law, K.Y., Sztriha, L., McGovern, A., Day, D., Mitchell-Douglas, J., Francis, J., Iqbal, A., Punjabivaryani, P., Anonuevo Reyes, J., Anonuevo Reyes, M., Pauls, M., Buch, A., Hedstrom, A., Hutchinson, C., Kirkland, C., Newham, J., Wilkes, G., Fleming, L., Fleck, N., Franca, A., Chwal, B., Oldoni, C., Mantovani, G., Noll, G., Zanella, L., Soma, M., Secchi, T., Borelli, W., Rimoli, B.P., da Cunha Silva, G.H., Machado Galvao Mondin, L.A., Barbosa Cerantola, R., Imthon, A.K., Esaki, A.S., Camilo, M., Vincenzi, O.C., ds Cruz, R.R., Morillos, M.B., Riccioppa Rodrigues, G.G., Santos Ferreira, K., Pazini, A.M., Pena Pereira, M.A., de Albuquerque, A.L.A., Massote Fontanini, C.E., Matinez Rubio, C.F., dos Santos, D.T., Dias, F.A., Alves, F.F.A., Milani, C., Pegorer Santos, B., Winckler, F., De Souza, J.T., Bonome, L.A.M., Cury Silva, V.A., Teodoro, R.S., Modolo, G.P., Ferreira, N.C., Barbosa dos Santos, D.F., dos Santos Moreira, J.C., Cruz Guedes de Morais, A.B., Vieira, J., Mendes, G., de Queiroz, J.P., Coutts, Shelagh B, Ankolekar, Sandeep, Appireddy, Ramana, Arenillas, Juan F, Assis, Zarina, Bailey, Peter, Barber, Philip A, Bazan, Rodrigo, Buck, Brian H, Butcher, Ken S, Camden, Marie-Christine, Campbell, Bruce C V, Casaubon, Leanne K, Catanese, Luciana, Chatterjee, Kausik, Choi, Philip M C, Clarke, Brian, Dowlatshahi, Dar, Ferrari, Julia, Field, Thalia S, Ganesh, Aravind, Ghia, Darshan, Goyal, Mayank, Greisenegger, Stefan, Halse, Omid, Horn, Mackenzie, Hunter, Gary, Imoukhuede, Oje, Kelly, Peter J, Kennedy, James, Kleinig, Timothy J, Krishnan, Kailash, Lima, Fabricio, Mandzia, Jennifer L, Marko, Martha, Martins, Sheila O, Medvedev, George, Menon, Bijoy K, Mishra, Sachin M, Molina, Carlos, Moussaddy, Aimen, Muir, Keith W, Parsons, Mark W, Penn, Andrew M W, Pille, Arthur, Pontes-Neto, Octávio M, Roffe, Christine, Serena, Joaquin, Simister, Robert, Singh, Nishita, Spratt, Neil, Strbian, Daniel, Tham, Carol H, Wiggam, M Ivan, Williams, David J, Willmot, Mark R, Wu, Teddy, Yu, Amy Y X, Zachariah, George, Zafar, Atif, Zerna, Charlotte, and Hill, Michael D
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- 2024
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3. Cold indoor temperatures and their association with health and well-being: a systematic literature review
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Janssen, H., Ford, K., Gascoyne, B., Hill, R., Roberts, M., Bellis, M.A., and Azam, S.
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- 2023
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4. Integrated impedance bridge for absolute capacitance measurements at cryogenic temperatures and finite magnetic fields
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Verbiest, G. J., Janssen, H., Xu, D., Ge, X., Goldsche, M., Sonntag, J., Khodkov, T., Banszerus, L., Driesch, N. von den, Buca, D., Watanabe, K., Taniguchi, T., and Stampfer, C.
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Physics - Instrumentation and Detectors ,Physics - Applied Physics - Abstract
We developed an impedance bridge that operates at cryogenic temperatures (down to 60 mK) and in perpendicular magnetic fields up to at least 12 T. This is achieved by mounting a GaAs HEMT amplifier perpendicular to a printed circuit board containing the device under test and thereby parallel to the magnetic field. The measured amplitude and phase of the output signal allows for the separation of the total impedance into an absolute capacitance and a resistance. Through a detailed noise characterization, we find that the best resolution is obtained when operating the HEMT amplifier at the highest gain. We obtained a resolution in the absolute capacitance of 6.4~aF$/\sqrt{\textrm{Hz}}$ at 77 K on a comb-drive actuator, while maintaining a small excitation amplitude of 15~$k_\text{B} T/e$. We show the magnetic field functionality of our impedance bridge by measuring the quantum Hall plateaus of a top-gated hBN/graphene/hBN heterostructure at 60~mK with a probe signal of 12.8~$k_\text{B} T/e$., Comment: 7 pages, 5 figures
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- 2019
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5. The dietary patterns, socio-demographic and lifestyle determinants, and metabolite fingerprints in a community sample of Merseyside takeaway food consumers
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Janssen, H.
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613.2 ,QH301 Biology ,RA0421 Public health. Hygiene. Preventive Medicine - Abstract
Background: Takeaway foods have increased in popularity over the past 40 years and there has been much debate regarding the determinants of their consumption. Whilst takeaway foods are thought to be associated with a number of non-communicable diseases, wider dietary patterns may be more predictive of disease risk than individual foods due to the synergistic effects of food combinations. However, accurate measurement of habitual food, particularly energy-dense nutrient-poor foods, using self-reported dietary assessment tools can be subject to participant bias. Recent research has demonstrated that metabolites derived from individual foods present in urine samples provide biomarkers of dietary exposure. Aim of PhD: To investigate takeaway food consumption within wider dietary patterns of a Merseyside population and their socio-demographic and lifestyle determinants. Additionally, to identify novel metabolite biomarkers from urine samples associated with takeaway foods as a means of validation of self-reported food consumption. Methods: Study 1) Design a food frequency questionnaire (Eating Habits Survey (EHS)) and conduct pilot (n = 26) to test the efficacy of methods prior to a larger scale study. Study 2) Record habitual and takeaway food consumption of study population (n = 1724) using the EHS and use principal component analysis (PCA) to determine dietary patterns. Study 3) Validate the EHS using three 24 hour ‘Multiple Pass’ dietary recalls (3 x 24 h MPR) and metabolomics on urine samples from a sub-sample (n = 151) from Study 2. Results: Being male, in a younger age group, having children in the household, alcohol use and smoking were positively associated (p < 0.05) with takeaway food consumption, whereas being in an older age group 3 and having higher qualifications were negatively (p < 0.01) associated. Nevertheless, specific takeaway food groups were associated at varying degrees. PCA identified some contrasting dietary patterns from the EHS and 3 x 24 h MPR, many of which included ultra-processed foods, and two concurring major patterns; ‘Western’ and ‘Prudent’. Metabolomics determined, for the first time, differences among the metabolite fingerprints of takeaway food consumers, and has shown good biomarker potential for kebab, Indian, English and Chinese takeaway food. Metabolomics validated self-reported dietary intake and determined urinary metabolites associated with habitual exposure to specific foods including poultry, coffee, alcohol, cocoa, oils, and fruit and vegetables. Conclusion: This research makes a novel contribution to knowledge and offers valuable insight into the determinants of takeaway food consumption and wider dietary patterns in the UK adult population. Moreover, it has built on an innovative metabolite fingerprinting technique that distinguishes food exposure from urinary samples. These findings should inform further research in this highly topical area and provide the evidence base to influence the formation of policy and interventions on takeaway food locally and in other areas.
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- 2019
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6. Non-pharmacological interventions to improve mental health outcomes among female carers of people living with a neurological condition: a systematic review
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Denham, A. M. J., primary, Haracz, K., additional, Bird, M. L., additional, Bonevski, B., additional, Spratt, N. J., additional, Turner, A., additional, Chow, W. Z., additional, Larkin, M., additional, Mabotuwana, N., additional, and Janssen, H., additional
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- 2024
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7. Slaap en slaapstoornissen
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Janssen, H. C. J. P., Stapper, J. H. E. M., Clijsen, M., editor, Garenfeld, W., editor, van Piere, M., editor, Klijs, C., editor, and Stringer, B., editor
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- 2020
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8. Secondary prevention of stroke. A telehealth-delivered physical activity and diet pilot randomized trial (ENAbLE-pilot)
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English, C, Ramage, ER, Attia, J, Bernhardt, J, Bonevski, B, Burke, M, Galloway, M, Hankey, GJ, Janssen, H, Lindley, R, Lynch, E, Oldmeadow, C, Said, CM, Spratt, NJ, Zacharia, K, MacDonald-Wicks, L, Patterson, A, English, C, Ramage, ER, Attia, J, Bernhardt, J, Bonevski, B, Burke, M, Galloway, M, Hankey, GJ, Janssen, H, Lindley, R, Lynch, E, Oldmeadow, C, Said, CM, Spratt, NJ, Zacharia, K, MacDonald-Wicks, L, and Patterson, A
- Abstract
BACKGROUND: Improving physical activity levels and diet quality are important for secondary stroke prevention. AIM: To test the feasibility and safety of 6-month, co-designed telehealth-delivered interventions to increase physical activity and improve diet quality. METHODS: A 2 × 2 factorial trial (physical activity (PA); diet (DIET); PA + DIET; control) randomized, open-label, blinded endpoint trial. Primary outcomes were feasibility and safety. Secondary outcomes included stroke risk factors (blood pressure, self-report PA (International Physical Activity Questionnaire (IPAQ)) and diet quality (Australian Recommended Food Score (ARFS)), and quality of life. Between-group differences were analyzed using linear-mixed models. RESULTS: Over 23 months, 99 people were screened for participation and 40 (40%) randomized (3 months to 10 years post-stroke, mean age 59 (16) years). Six participants withdrew, and an additional five were lost to follow-up. Fifteen serious adverse events were reported, but none were deemed definitely or probably related to the intervention. Median attendance was 32 (of 36) PA sessions and 9 (of 10) DIET sessions. The proportion of missing primary outcome data (blood pressure) was 3% at 3 months, 11% at 6 months, and 14% at 12 months. Between-group 95% confidence intervals showed promising, clinically relevant differences in support of the interventions across the range of PA, diet quality, and blood pressure outcomes. CONCLUSION: Our telehealth PA and diet interventions were safe and feasible and may have led to significant behavior change. TRIAL REGISTRATION: ACTRN12620000189921.
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- 2024
9. How to verify the precision of density-functional-theory implementations via reproducible and universal workflows
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Bosoni, E., Beal, L., Bercx, M., Blaha, P., Blugel, S., Broder, J., Callsen, M., Cottenier, S., Degomme, A., Dikan, V., Eimre, K., Flage-Larsen, E., Fornari, M., Garcia, A., Genovese, L., Giantomassi, M., Huber, S. P., Janssen, H., Kastlunger, G., Krack, M., Kresse, G., Kühne, T. D.-S., Lejaeghere, K., Madsen, G. K. H., Marsman, M., Marzari, N., Michalicek, G., Mirhosseini, H., Muller, T. M. A., Petretto, G., Pickard, C. J., Ponce, S., Rignanese, G.-M., Rubel, O., Ruh, T., Sluydts, M., Vanpoucke, D. E. P., Vijay, S., Wolloch, M., Wortmann, D., Yakutovich, A. V., Yu, J., Zadoks, A., Zhu, B., Pizzi, G., Bosoni, E., Beal, L., Bercx, M., Blaha, P., Blugel, S., Broder, J., Callsen, M., Cottenier, S., Degomme, A., Dikan, V., Eimre, K., Flage-Larsen, E., Fornari, M., Garcia, A., Genovese, L., Giantomassi, M., Huber, S. P., Janssen, H., Kastlunger, G., Krack, M., Kresse, G., Kühne, T. D.-S., Lejaeghere, K., Madsen, G. K. H., Marsman, M., Marzari, N., Michalicek, G., Mirhosseini, H., Muller, T. M. A., Petretto, G., Pickard, C. J., Ponce, S., Rignanese, G.-M., Rubel, O., Ruh, T., Sluydts, M., Vanpoucke, D. E. P., Vijay, S., Wolloch, M., Wortmann, D., Yakutovich, A. V., Yu, J., Zadoks, A., Zhu, B., and Pizzi, G.
- Abstract
Density-functional theory methods and codes adopting periodic boundary conditions are extensively used in condensed matter physics and materials science research. In 2016, their precision (how well properties computed with different codes agree among each other) was systematically assessed on elemental crystals: a first crucial step to evaluate the reliability of such computations. In this Expert Recommendation, we discuss recommendations for verification studies aiming at further testing precision and transferability of density-functional-theory computational approaches and codes. We illustrate such recommendations using a greatly expanded protocol covering the whole periodic table from Z = 1 to 96 and characterizing 10 prototypical cubic compounds for each element: four unaries and six oxides, spanning a wide range of coordination numbers and oxidation states. The primary outcome is a reference dataset of 960 equations of state cross-checked between two all-electron codes, then used to verify and improve nine pseudopotential-based approaches. Finally, we discuss the extent to which the current results for total energies can be reused for different goals.
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- 2024
10. Emotional and non-emotional mental imagery and auditory verbal hallucinations (hearing voices): A systematic review of imagery assessment tools.
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Janssen, H. and Janssen, H.
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- Experimental Psychopathology and Treatment.
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- 2024
11. Features of durable response and treatment efficacy for capecitabine monotherapy in advanced breast cancer: real-world evidence from a large single-centre cohort
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Thijssen, S., Wildiers, H., Punie, K., Beuselinck, B., Clement, P., Remmerie, C., Berteloot, P., Han, S., Van Nieuwenhuysen, E., Van Gorp, T., Vergote, I., Smeets, A., Nevelsteen, I., Floris, G., Weltens, C., Menten, J., Janssen, H., Laenen, A., and Neven, P.
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- 2021
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12. Input and Output Coefficients of Various Cropping and Livestock Systems in the European Communities
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van Keulen, H., Janssen, H., and de Koning, G.H.J.
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economics ,european union ,economie ,europese unie ,Clay ,Fertilizer ,Fungicide ,Herbicide ,Maize ,Nitrogen ,Potato ,Sugar beet ,Wheat ,bic Book Industry Communication::K Economics, finance, business & management::KC Economics - Abstract
Economics; European Union, De serie 'Werkdocumenten' omvat stukken die in het kader van de werkzaamheden van de WRR tot stand zijn gekomen en die op aanvraag door de raad beschikbaar worden gesteld. De verantwoordelijkheid voor de inhoud en de ingenomen standpunten berust bij de auteurs.
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- 1992
13. Optimizing therapy in primary biliary cholangitis: Alkaline phosphatase at six months identifies one-year non-responders and predicts survival
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Murilloperez, C, Ioannou, S, Hassanally, I, Trivedi, P, Corpechot, C, van der Meer, A, Lammers, W, Battezzati, P, Lindor, K, Nevens, F, Kowdley, K, Bruns, T, Cazzagon, N, Floreani, A, Mason, A, Gulamhusein, A, Ponsioen, C, Carbone, M, Lleo, A, Mayo, M, Dalekos, G, Gatselis, N, Thorburn, D, Verhelst, X, Pares, A, Londono, M, Janssen, H, Invernizzi, P, Vuppalanchi, R, Hirschfield, G, Hansen, B, Levy, C, MurilloPerez C. F., Ioannou S., Hassanally I., Trivedi P. J., Corpechot C., van der Meer A. J., Lammers W. J., Battezzati P. M., Lindor K. D., Nevens F., Kowdley K. V., Bruns T., Cazzagon N., Floreani A., Mason A. L., Gulamhusein A., Ponsioen C. Y., Carbone M., Lleo A., Mayo M. J., Dalekos G. N., Gatselis N. K., Thorburn D., Verhelst X., Pares A., Londono M. -C., Janssen H. L. A., Invernizzi P., Vuppalanchi R., Hirschfield G. M., Hansen B. E., Levy C., Murilloperez, C, Ioannou, S, Hassanally, I, Trivedi, P, Corpechot, C, van der Meer, A, Lammers, W, Battezzati, P, Lindor, K, Nevens, F, Kowdley, K, Bruns, T, Cazzagon, N, Floreani, A, Mason, A, Gulamhusein, A, Ponsioen, C, Carbone, M, Lleo, A, Mayo, M, Dalekos, G, Gatselis, N, Thorburn, D, Verhelst, X, Pares, A, Londono, M, Janssen, H, Invernizzi, P, Vuppalanchi, R, Hirschfield, G, Hansen, B, Levy, C, MurilloPerez C. F., Ioannou S., Hassanally I., Trivedi P. J., Corpechot C., van der Meer A. J., Lammers W. J., Battezzati P. M., Lindor K. D., Nevens F., Kowdley K. V., Bruns T., Cazzagon N., Floreani A., Mason A. L., Gulamhusein A., Ponsioen C. Y., Carbone M., Lleo A., Mayo M. J., Dalekos G. N., Gatselis N. K., Thorburn D., Verhelst X., Pares A., Londono M. -C., Janssen H. L. A., Invernizzi P., Vuppalanchi R., Hirschfield G. M., Hansen B. E., and Levy C.
- Abstract
Background and Aims: Patients with primary biliary cholangitis (PBC) and insufficient response to ursodeoxycholic acid (UDCA), currently assessed after 1 year, are candidates for second-line therapy. The aims of this study are to assess biochemical response pattern and determine the utility of alkaline phosphatase (ALP) at six months as a predictor of insufficient response. Methods: UDCA-treated patients in the GLOBAL PBC database with available liver biochemistries at one year were included. POISE criteria were used to assess response to treatment, defined as ALP <1.67 × upper limit of normal (ULN) and normal total bilirubin at one year. Various thresholds of ALP at six months were evaluated to predict insufficient response based on negative predictive value (NPV) and that with nearest to 90% NPV was selected. Results: For the study, 1362 patients were included, 1232 (90.5%) female, mean age of 54 years. The POISE criteria were met by 56.4% (n = 768) of patients at one year. The median ALP (IQR) of those who met POISE criteria compared to those who did not was 1.05 × ULN (0.82–1.33) vs. 2.37 × ULN (1.72–3.69) at six months (p <.001). Of 235 patients with serum ALP >1.9 × ULN at six months, 89% did not achieve POISE criteria (NPV) after one year of UDCA. Of those with insufficient response by POISE criteria at one year, 210 (67%) had an ALP >1.9 × ULN at six months and thus would have been identified early. Conclusions: We can identify patients for second-line therapy at six months using an ALP threshold of 1.9 × ULN, given that approximately 90% of these patients are non-responders according to POISE criteria.
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- 2023
14. Geographical region and clinical outcomes of patients with primary biliary cholangitis from Western Europe
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Murillo Perez, C, Gerussi, A, Trivedi, P, Corpechot, C, Van Der Meer, A, Maria Battezzati, P, Lindor, K, Nevens, F, Kowdley, K, Bruns, T, Cazzagon, N, Floreani, A, Tanaka, A, Ma, X, Mason, A, Gulamhusein, A, Ponsioen, C, Carbone, M, Lleo, A, Mayo, M, Dalekos, G, Gatselis, N, Thorburn, D, Verhelst, X, Pares, A, Janssen, H, Hirschfield, G, Hansen, B, Invernizzi, P, Lammers, W, Murillo Perez C. F., Gerussi A., Trivedi P. J., Corpechot C., Van Der Meer A. J., Maria Battezzati P., Lindor K. D., Nevens F., Kowdley K. V., Bruns T., Cazzagon N., Floreani A., Tanaka A., Ma X., Mason A. L., Gulamhusein A., Ponsioen C. Y., Carbone M., Lleo A., Mayo M. J., Dalekos G. N., Gatselis N. K., Thorburn D., Verhelst X., Pares A., Janssen H. L. A., Hirschfield G. M., Hansen B. E., Invernizzi P., Lammers W. J., Murillo Perez, C, Gerussi, A, Trivedi, P, Corpechot, C, Van Der Meer, A, Maria Battezzati, P, Lindor, K, Nevens, F, Kowdley, K, Bruns, T, Cazzagon, N, Floreani, A, Tanaka, A, Ma, X, Mason, A, Gulamhusein, A, Ponsioen, C, Carbone, M, Lleo, A, Mayo, M, Dalekos, G, Gatselis, N, Thorburn, D, Verhelst, X, Pares, A, Janssen, H, Hirschfield, G, Hansen, B, Invernizzi, P, Lammers, W, Murillo Perez C. F., Gerussi A., Trivedi P. J., Corpechot C., Van Der Meer A. J., Maria Battezzati P., Lindor K. D., Nevens F., Kowdley K. V., Bruns T., Cazzagon N., Floreani A., Tanaka A., Ma X., Mason A. L., Gulamhusein A., Ponsioen C. Y., Carbone M., Lleo A., Mayo M. J., Dalekos G. N., Gatselis N. K., Thorburn D., Verhelst X., Pares A., Janssen H. L. A., Hirschfield G. M., Hansen B. E., Invernizzi P., and Lammers W. J.
- Abstract
Background and aims The are geographic variations in the incidence and prevalence of primary biliary cholangitis (PBC). The aim was to explore whether clinical outcomes of patients within Western Europe differ according to geographical region. Methods Ursodeoxycholic acid-treated patients from European centers from the Global PBC database diagnosed from 1990 onwards were included. Patients with a time lag > 1 year from diagnosis to start of follow-up were excluded. Differences in baseline characteristics were studied according to North/South and East/West, whereas outcomes (transplant-free survival and decompensation) were studied with center latitude and longitude. Cox regression analyses were adjusted for age, sex, diagnosis year, biochemical markers, and cirrhosis as a time-dependent covariate. Results One thousand eight hundred seventy-eight patients were included, and there were no geographical differences in age or sex, with a mean age of 54 years and 89% female patients. Those in North Europe were more often of a moderately advanced/advanced Rotterdam biochemical stage (28.4%) compared with South Europe (20.6%). Additionally, they exhibited higher median alkaline phosphatase (2.0 ×ULN vs. 1.4 ×ULN) and transaminases. In multivariable analysis, there was a significant interaction between center latitude and longitude for decompensation (P < 0.001) and a trend for transplant-free survival, in which the Northwestern area demonstrated an increased risk for poor outcomes as compared to the reference (Paris). Conclusion We describe geographic variations in outcomes for patients across Europe from specialist centers in the Global PBC Study Group. Further study is important to explore the potential individual, environmental, and healthcare-related factors that may be contributors.
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- 2023
15. Adaptive tape placement process control at geometrically changing substrates
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Brecher, C., Emonts, M., Striet, P., Voell, A., Stollenwerk, J., and Janssen, H.
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- 2019
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16. Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial
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Coutts, Shelagh B, Ankolekar, Sandeep, Appireddy, Ramana, Arenillas, Juan F, Assis, Zarina, Bailey, Peter, Barber, Philip A, Bazan, Rodrigo, Buck, Brian H, Butcher, Ken S, Camden, Marie-Christine, Campbell, Bruce C V, Casaubon, Leanne K, Catanese, Luciana, Chatterjee, Kausik, Choi, Philip M C, Clarke, Brian, Dowlatshahi, Dar, Ferrari, Julia, Field, Thalia S, Ganesh, Aravind, Ghia, Darshan, Goyal, Mayank, Greisenegger, Stefan, Halse, Omid, Horn, Mackenzie, Hunter, Gary, Imoukhuede, Oje, Kelly, Peter J, Kennedy, James, Kenney, Carol, Kleinig, Timothy J, Krishnan, Kailash, Lima, Fabricio, Mandzia, Jennifer L, Marko, Martha, Martins, Sheila O, Medvedev, George, Menon, Bijoy K, Mishra, Sachin M, Molina, Carlos, Moussaddy, Aimen, Muir, Keith W, Parsons, Mark W, Penn, Andrew M W, Pille, Arthur, Pontes-Neto, Octávio M, Roffe, Christine, Serena, Joaquin, Simister, Robert, Singh, Nishita, Spratt, Neil, Strbian, Daniel, Tham, Carol H, Wiggam, M Ivan, Williams, David J, Willmot, Mark R, Wu, Teddy, Yu, Amy Y X, Zachariah, George, Zafar, Atif, Zerna, Charlotte, Hill, Michael D, Salluzzi, Marina, Blenkin, Nicole, Dueck, Ashley, Doram, Craig, Zhang, Qiao, Kenney, Carol, Ryckborst, Karla, Bohn, Shelly, Collier, Quentin, Taylor, Frances, Lethebe, B. Cord, Jambula, Anitha, Sage, Kayla, Toussaint, Lana, Save, Supryia, Lee, Jaclyn, Laham, N, Sultan, A.A., Deepak, A., Sitaram, A., Demchuk, Andrew M., Lockey, A., Micielli, A., Wadhwa, A., Arabambi, B., Graham, B., Bogiatzi, Chrysi, Doshi, Darshan, Chakraborty, D., Kim, Diana, Vasquez, D, Singh, D, Tse, Dominic, Harrison, E., Smith, E.E., Teleg, E., Klourfeld, E., Klein, G., Sebastian, I.A., Evans, J, Hegedus, J, Kromm, J, Lin, K, Ignacio, K, Ghavami, Kimia, Ismail, M., Moores, M., Panzini, M.A., Boyko, M., Almekhlafi, M.A., Newcommon, Nancy, Maraj, N., Imoukhuede, O., Volny, O., Stys, Peter, Couillard, Phillipe, Ojha, P., Eswaradass, P., Joundi, Raed, Singh, R., Asuncion, R.M., Muir, R.T., Dey, S., Mansoor, S., Wasyliw, S., Nagendra, S., Hu, Sherry, Althubait, S., Chen, S., Bal, S., Van Gaal, Stephen, Peters, Steven, Ray, Sucharita, Chaturvedi, S., Subramaniam, Suresh, Fu, Vivian, Villaluna, K., Maclean, G., King-Azote, P., Ma, C., Plecash, A., Murphy, C., Gorman, J., Wilson, L., Zhou, L., Benevente, O., Teal, P., Yip, S., Mann, S., Dewar, B., Demetroff, M., Shamloul, R., Beardshaw, R., Roberts, S., Blaquiere, D., Stotts, G., Shamy, M., Bereznyakova, O., Fahed, R., Alesefir, W., Lavoie, Suzy, Hache, A., Collard, K, Mackey, A., Gosselin-Lefebvre, S., Verreault, S., Beauchamp, B., Lambourn, L., Khaw, A., Mai, L., Sposato, L., Bres Bullrich, M., Azarpazhooh, R., Fridman, S., Kapoor, A., Southwell, A., Bardi, E., Fatakdawala, I., Kamra, M, Lopes, K., Popel, N., Norouzi, V., Liu, A., Liddy, A.M., Ghoari, B., Hawkes, C., Enriquez, C.A., Gladstone, D.J., Manosalva Alzate, H.A., Khosravani, H., Hopyan, J.J., Sivakumar, K., Son, M., Boulos, M.I., Hamind, M.A., Swartz, R.H., Murphy, R., Reiter, S., Fitzpatrick, T., Bhandari, V., Good, J., Penn, M., Naylor, M., Frost, S., Cayley, A., Akthar, F., Williams, J., Kalman, L., Crellin, L., Wiegner, R., Singh, R.S., Stewart, T., To, W., Singh, S., Pikula, A., Jaigobin, C., Carpani, F., Silver, F., Janssen, H., Schaafsma, J., del Campo, M., Alskaini, M., Rajendram, P., Fairall, P., Granfield, B., Crawford, D., Jabs, J., White, L., Sivakumar, L., Piquette, L., Nguyen, T., Nomani, A., Wagner, A., Alrohimi, A., Butt, A., D'Souza, A., Gajurel, B., Vekhande, C., Kamble, H., Kalashyan, H., Lloret, M., Benguzzi, M., Arsalan, N., Ishaque, N., Ashayeriahmadabad, R., Samiento, R., Hosseini, S., Kazi, S., Das, S., Sugumar, T., Selchen, D., Kostyrko, P., Muccilli, A., Saposnik, A.G., Vandervelde, C., Ratnayake, K., McMillan, S., Katsanos, A., Shoamanesh, A., Sahlas, D.J., Naidoo, V., Todorov, V., Toma, H., Brar, J., Lee, J., Horton, M., Chen, S., Shand, E., Weatherby, S., Jin, A., Durafourt, B., Jalini, S., Gardner, A., Tyson, C., Junk, E., Foster, K., Bolt, K., Sylvain, N., Maley, S., Urroz, L., Peeling, L., Kelly, M., Whelan, R., Cooley, R., Teitelbaum, J., Boutayeb, A., Moore, A., Cole, E., Waxman, L., Ben-Amor, N., Sanchez, R., Khalil, S., Nehme, A., Legault, C., Tampieri, D., Ehrensperger, E., Vieira, L., Cortes, M., Angle, M., Hannouche, M., Badawy, M., Werner, K., Wieszmuellner, S., Langer, A., Gisold, A., Zach, H., Rommer, P., Macher, S., Blechinger, S., Marik, W., Series, W., Baumgartinger, M., Krebs, S., Koski, J., Eirola, S., Ivanoff, T., Erakanto, A., Kupari, L., Sibolt, G., Panula, J., Tomppo, L., Tiainen, M., Ahlstrom, M., Martinez Majander, N., Suomalainen, O., Raty, S., Levi, C., Kerr, E., Allen, J., Kaauwai, L.P., Belevski, L., Russell, M., Ormond, S., Chew, A., Loiselle, A., Royan, A., Hughes, B., Garcia Esperon, C., Pepper, E., Miteff, F., He, J., Lycett, M., Min, M., Murray, N., Pavey, N., Starling de Barros, R., Gangadharan, S., Dunkerton, S., Waller, S., Canento Sanchez, T., Wellings, T., Edmonds, G., Whittaker, K.A., Ewing, M., Lee, P., Singkang, R., McDonald, A., Dos Santos, A., Shin, C., Jackson, D., Tsoleridis, J., Fisicchia, L., Parsons, N., Shenoy, N., Smith, S., Sharobeam, A., Balabanski, A., Park, A., Williams, C., Pavlin-Premri, D., Rodrigues, E., Alemseged, F., Ng, F., Zhao, H., Beharry, J., Ng, J.L., Williamson, J., Wong, J.Z.W., Li, K., Kwan, M.K., Valente, M., Yassi, N., Cooley, R., Yogendrakumar, V., McNamara, B., Buchanan, C., McCarthy, C., Thomas, G., Stephens, K., Chung, M., Chung, M.F., Tang, M., Busch, T., Frost, T., Lee, R., Stuart, N., Pachani, N., Menon, A., Borojevic, B., Linton, C.M., Garcia, G., Callaly, E.P., Dewey, H., Liu, J., Chen, J., Wong, J., Nowak, K., To, K., Lizak, N.S., Bhalala, O., Park, P., Tan, P., Martins, R., Cody, R., Forbes, R., Chen, S.K., Ooi, S., Tu, S., Dang, Y.L., Ling, Z., Cranefield, J., Drew, R., Tan, A., Kurunawai, C., Harvey, J., Mahadevan, J.J., Cagi, L., Palanikumar, L., Chia, L.N., Goh, R., El-Masri, S., Urbi, B., Rapier, C., Berrill, H., McEvoy, H., Dunning, R., Kuriakose, S., Chad, T., Sapaen, V., Sabet, A., Shah, D., Yeow, D., Lilley, K., Ward, K., Mozhy Mahizhnan, M., Tan, M., Lynch, C., Coveney, S., Tobin, K., McCabe, J., Marnane, M., Murphy, S., Large, M., Moynihan, B., Boyle, K., Sanjuan, E., Sanchis, M., Boned, S., Pancorbo, O., Sala, V., Garcia, L., Garcia-Tornel, A., Juega, J., Pagola, J., Santana, K., Requena, M., Muchada, M., Olive, M., Lozano, P.J., Rubiera, M., Deck, M., Rodriguez, N., Gomez, B., Reyes Munoz, F.J., Gomez, A.S., Sanz, A.C., Garcia, E.C., Penacoba, G., Ramos, M.E., de Lera Alfonso, M., Feliu, A, Pardo, L., Ramirez, P., Murillo, A., Lopez Dominguez, D., Rodriguez, J., Terceno Izaga, M., Reina, M., Viturro, S.B., Bojaryn, U., Vera Monge, V.A., Silva Blas, Y., R Siew, R., Agustin, S J, Seet, C., Tianming, T., d'Emden, A., Murray, A., Welch, A., Hatherley, K., Day, N., Smith, W., MacRae, E., Mitchell, E.S., Mahmood, A., Elliot, J., Neilson, S., Biswas, V., Brown, C., Lewis, A., Ashton, A., Werring, D., Perry, R., Muhammad, R., Lee, Y.C., Black, A., Robinson, A., Williams, A., Banaras, A., Cahoy, C., Raingold, G., Marinescu, M., Atang, N., Bason, N., Francia, N., Obarey, S., Feerick, S., Joseph, J., Schulz, U., Irons, R., Benjamin, J., Quinn, L., Jhoots, M., Teal, R., Ford, G., Harston, G., Bains, H., Gbinigie, I., Mathieson, P., Irons, R., Sim, C.H., Hayter, E., Kennedy, K., Binnie, L., Priestley, N., Williams, R., Ghatala, R., Stratton, S., Blight, A., Zhang, L., Davies, A., Duffy, H., Roberts, J., Homer, J., Roberts, K., Dodd, K., Cawley, K., Martin, M., Leason, S., Cotgreave, S., Taylor, T., Nallasivan, A., Haider, S., Chakraborty, T., Webster, T., Gil, A., Martin, B., Joseph, B., Cabrera, C., Jose, D., Man, J., Aquino, J., Sebastian, S., Osterdahl, M., Kwan, M., Matthew, M., Ike, N., Bello, P., Wilding, P., Fuentes, R., Shah, R., Mashate, S., Patel, T., Nwanguma, U., Dave, V., Haber, A., Lee, A., O'Sullivan, A., Drumm, B., Dawson, A.C., Matar, T., Biswas, V., Roberts, D., Taylor, E., Rounis, E., El-Masry, A., O'Hare, C., Kalladka, D., Jamil, S., Auger, S., Raha, O., Evans, M., Vonberg, F., Kalam, S., Ali Sheikh, A., Jenkins, I.H., George, J., Kwan, J., Blagojevic, J., Saeed, M., Haji-Coll, M., Tsuda, M., Sayed, M., Winterkron, N., Thanbirajah, N., Vittay, O., Karim, R., Smail, R.C., Gauhar, S., Elmamoun, S., Malani, S., Pralhad Kelavkar, S., Hiden, J., Ferdinand, P., Sanyal, R., Varquez, R., Smith, B., Okechukwu, C., Fox, E., Collins, E., Courtney, K., Tauro, S., Patterson, C., McShane, D., Kerr, E., Roberts, G., McIImoyle, J., McGuire, K., Fearon, P., Gordon, P., Isaacs, K., Lucas, K., Smith, L., Dews, L., Bates, M., Lawrence, S., Heeley, S., Patel, V., Chin, Y.M., Sims, D., Littleton, E., Khaira, J., Nadar, K., Kieliszkowska, A., Sari, B., Domingos Belo, C., Smith, E., Manolo, E.Y., Aeron-Thomas, J., Doheny, M., Garcia Pardo, M., Recaman, M., Tibajia, M.C., Aissa, M., Mah, Y., Yu, T., Patel, V., Meenakshisundaram, S., Heller, S., Alsukhni, R., Williams, O., Farag, M., Benger, M., Engineer, A., Aissa, M., Bayhonan, S., Conway, S., Bhalla, A., Nouvakis, D., Theochari, E., Boyle, F., Teo, J., King-Robson, J., Law, K.Y., Sztriha, L., Ismail, M., McGovern, A., Day, D., Mitchell-Douglas, J., Francis, J., Iqbal, A., Punjabivaryani, P., Anonuevo Reyes, J., Anonuevo Reyes, M., Pauls, M., Buch, A., Hedstrom, A., Hutchinson, C., Kirkland, C., Newham, J., Wilkes, G., Fleming, L., Fleck, N., Franca, A., Chwal, B., Oldoni, C., Mantovani, G., Noll, G., Zanella, L., Soma, M., Secchi, T., Borelli, W., Rimoli, B.P., da Cunha Silva, G.H., Machado Galvao Mondin, L.A., Barbosa Cerantola, R., Imthon, A.K., Esaki, A.S., Camilo, M., Vincenzi, O.C., ds Cruz, R.R., Morillos, M.B., Riccioppa Rodrigues, G.G., Santos Ferreira, K., Pazini, A.M., Pena Pereira, M.A., de Albuquerque, A.L.A., Massote Fontanini, C.E., Matinez Rubio, C.F., dos Santos, D.T., Dias, F.A., Alves, F.F.A., Milani, C., Pegorer Santos, B., Winckler, F., De Souza, J.T., Bonome, L.A.M., Cury Silva, V.A., Teodoro, R.S., Modolo, G.P., Ferreira, N.C., Barbosa dos Santos, D.F., dos Santos Moreira, J.C., Cruz Guedes de Morais, A.B., Vieira, J., Mendes, G., and de Queiroz, J.P.
- Abstract
Individuals with minor ischaemic stroke and intracranial occlusion are at increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve outcomes in this population. We aimed to test the superiority of intravenous tenecteplase over non-thrombolytic standard of care in patients with minor ischaemic stroke and intracranial occlusion or focal perfusion abnormality.
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- 2024
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17. Real‐world hepatitis C prevalence and treatment uptake at opioid agonist therapy clinics in Ontario, Canada.
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Wolfson‐Stofko, B., Hirode, G., Vanderhoff, A., Karkada, J., Capraru, C., Biondi, M. J., Hansen, B., Shah, H., Janssen, H. L. A., and Feld, J. J.
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HEPATITIS C ,HEPATITIS C virus ,MEDICAL screening ,ANTIVIRAL agents ,BUPRENORPHINE ,PATIENT compliance ,OPIOIDS ,OATS - Abstract
Widespread screening for hepatitis C virus (HCV) is necessary for Canada to meet its HCV elimination goals by 2030. People who currently or previously injected drugs are at high risk for HCV. Opioid agonist therapy (OAT, such as methadone and buprenorphine) has been shown to help stabilize the lives of people who are opioid‐dependent. The distribution of OAT in North America typically requires daily, weekly, or monthly clinic visits and presents an opportunity for engagement, screening and treatment for those at high‐risk of HCV. In this study, HCV screening was conducted by staff at OAT clinics in Ontario from 2016 to 2020 and those with chronic infections were treated on‐site with direct‐acting antivirals. Point‐of‐care or dried blood spot (DBS) testing was used for antibodies, DBS or serum for HCV RNA and serum for HCV RNA at SVR12 (sustained virological response). Clinics screened 1954 people (mean age 40 years ±12, 63% male). Forty‐five percent were antibody positive, of whom 64% were HCV RNA+. Eighty percent of those RNA+ set an appointment in which 99% attended. Ninety‐six percent started treatment with 87% completing treatment. Sixty‐eight percent of people who completed treatment submitted a sample for SVR12 testing of which 97% achieved a virological cure. Results suggest that HCV screening and treatment at OAT clinics is feasible, effective and warrants expansion. Data suggest strong treatment adherence due to high rates of SVR12 comparable with other OAT‐based HCV treatment programs. The lack of SVR12 sampling could be addressed by either on‐site phlebotomy or incentivizing SVR12 sampling. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Feature based bipolar plate forming.
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Meelkop, D., Janssen, H., and Brecher, C.
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- 2024
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19. Universal properties of population dynamics with fluctuating resources
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Mukherjee, Sayak, Janssen, H. K., and Schmittmann, B.
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Condensed Matter - Statistical Mechanics - Abstract
Starting from the well-known field theory for directed percolation, we describe an evolving population, near extinction, in an environment with its own nontrivial spatio-temporal dynamics. Here, we consider the special case where the environment follows a simple relaxational (Model A) dynamics. Two new operators emerge, with upper critical dimension of four, which couple the two theories in a nontrivial way. While the Wilson-Fisher fixed point remains completely unaffected, a mismatch of time scales destabilizes the usual DP fixed point, suggesting a crossover to a first order transition from the active (surviving) to the inactive (extinct) state., Comment: 4 Pages
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- 2007
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20. Novel surface universality classes with strong anisotropy
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Schmittmann, B., Pruessner, Gunnar, and Janssen, H. K.
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Condensed Matter - Statistical Mechanics ,Condensed Matter - Materials Science - Abstract
Using renormalized field theory, we examine the dynamics of a growing surface, driven by an obliquely incident particle beam. Its projection on the reference (substrate) plane selects a ``parallel'' direction, so that the evolution equation for the surface height becomes anisotropic. The phase diagram of the model is controlled by the properties of an effective anisotropic surface tension. Our renormalization group analysis suggests the existence of a line of continuous transitions and a line of (potentially) first-order transitions, which meet at a multicritical point. The full scaling behavior for the continuous line and the multicritical point is discussed in detail. Two novel universality classes for scale-invariant surface fluctuations are found., Comment: 25 pages, 1 figure. Accepted by Journal of Physics A: Special Issue on Renormalization Group 2005
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- 2006
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21. Finite-size scaling of directed percolation above the upper critical dimension
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Lubeck, S. and Janssen, H. -K.
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Condensed Matter - Statistical Mechanics - Abstract
We consider analytically as well as numerically the finite-size scaling behavior in the stationary state near the non-equilibrium phase transition of directed percolation within the mean field regime, i.e., above the upper critical dimension. Analogous to equilibrium, usual finite-size scaling is valid below the upper critical dimension, whereas it fails above. Performing a momentum analysis of associated path integrals we derive modified finite-size scaling forms of the order parameter and its higher moments. The results are confirmed by numerical simulations of corresponding high-dimensional lattice models., Comment: 4 pages, one figure
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- 2005
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22. The impact of salt pore clogging on the hygric properties of bricks
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Todorović, J. and Janssen, H.
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- 2018
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23. Perioperative kardiovaskuläre Morbidität und Letalität bei nichtherzchirurgischen Eingriffen: Maßnahmen der optimalen anästhesiologischen Betreuung
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Janßen, H., Dehne, S., Giannitsis, E., Weigand, M. A., and Larmann, J.
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- 2019
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- View/download PDF
24. New-generation positional therapy in patients with positional central sleep apnea
- Author
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Benoist, L. B. L., Vonk, P. E., de Vries, N., Janssen, H. C. J. P., and Verbraecken, J.
- Published
- 2019
- Full Text
- View/download PDF
25. Comparison of brachytherapy and external beam radiotherapy boost in breast-conserving therapy: Patient-reported outcome measures and aesthetic outcome
- Author
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Kindts, I., Laenen, A., Christiaens, M., Janssen, H., Van Limbergen, E., and Weltens, C.
- Published
- 2019
- Full Text
- View/download PDF
26. Master Operators Govern Multifractality in Percolation
- Author
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Stenull, O. and Janssen, H. K.
- Subjects
Condensed Matter - Statistical Mechanics ,Condensed Matter - Disordered Systems and Neural Networks - Abstract
Using renormalization group methods we study multifractality in percolation at the instance of noisy random resistor networks. We introduce the concept of master operators. The multifractal moments of the current distribution (which are proportional to the noise cumulants $C_R^{(l)} (x, x^\prime)$ of the resistance between two sites x and $x^\prime$ located on the same cluster) are related to such master operators. The scaling behavior of the multifractal moments is governed exclusively by the master operators, even though a myriad of servant operators is involved in the renormalization procedure. We calculate the family of multifractal exponents ${\psi_l}$ for the scaling behavior of the noise cumulants, $C_R^{(l)} (x, x^\prime) \sim | x - x^\prime |^{\psi_l /\nu}$, where $\nu$ is the correlation length exponent for percolation, to two-loop order., Comment: 6 pages
- Published
- 2000
- Full Text
- View/download PDF
27. Viability of competing field theories for the driven lattice gas
- Author
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Schmittmann, B., Janssen, H. K., Taeuber, U. C., Zia, R. K. P., Leung, K. -t., and Cardy, J. L.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
It has recently been suggested that the driven lattice gas should be described by a novel field theory in the limit of infinite drive. We review the original and the new field theory, invoking several well-documented key features of the microscopics. Since the new field theory fails to reproduce these characteristics, we argue that it cannot serve as a viable description of the driven lattice gas. Recent results, for the critical exponents associated with this theory, are re-analyzed and shown to be incorrect., Comment: 4 pages, revtex, no figures
- Published
- 1999
- Full Text
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28. Diluted Networks of Nonlinear Resistors and Fractal Dimensions of Percolation Clusters
- Author
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Janssen, H. K. and Stenull, O.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
We study random networks of nonlinear resistors, which obey a generalized Ohm's law, $V\sim I^r$. Our renormalized field theory, which thrives on an interpretation of the involved Feynman Diagrams as being resistor networks themselves, is presented in detail. By considering distinct values of the nonlinearity r, we calculate several fractal dimensions characterizing percolation clusters. For the dimension associated with the red bonds we show that $d_{\scriptsize red} = 1/\nu$ at least to order ${\sl O} (\epsilon^4)$, with $\nu$ being the correlation length exponent, and $\epsilon = 6-d$, where d denotes the spatial dimension. This result agrees with a rigorous one by Coniglio. Our result for the chemical distance, $d_{\scriptsize min} = 2 - \epsilon /6 - [ 937/588 + 45/49 (\ln 2 -9/10 \ln 3)] (\epsilon /6)^2 + {\sl O} (\epsilon^3)$ verifies a previous calculation by one of us. For the backbone dimension we find $D_B = 2 + \epsilon /21 - 172 \epsilon^2 /9261 + 2 (- 74639 + 22680 \zeta (3))\epsilon^3 /4084101 + {\sl O} (\epsilon^4)$, where $\zeta (3) = 1.202057...$, in agreement to second order in $\epsilon$ with a two-loop calculation by Harris and Lubensky., Comment: 29 pages, 7 figures
- Published
- 1999
- Full Text
- View/download PDF
29. Field Theory of Critical Behaviour in Driven Diffusive Systems with Quenched Disorder
- Author
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Becker, V. and Janssen, H. K.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
We present a field theoretic renormalization group study for the critical behaviour of a uniformly driven diffusive system with quenched disorder, which is modelled by different kinds of potential barriers between sites. Due to their symmetry properties, these different realizations of the random potential barriers lead to three different models for the phase transition to transverse order and to one model for the phase transition to longitudinal order all belonging to distinct universality classes. In these four models that have different upper critical dimensions d_{c} we find the critical scaling behaviour of the vertex functions in spatial dimensions d < d_{c} . Its deviation from purely diffusive behaviour is characterized by the anomaly-exponent \eta that we calculate at first and second order, respectively in $\epsilon = d_{c} -d$. In each model \eta turns out to be positive which means superdiffusive spread of density fluctuations in the driving force direction., Comment: 47 pages, 6 figures
- Published
- 1999
- Full Text
- View/download PDF
30. The Resistance of Feynman Diagrams and the Percolation Backbone Dimension
- Author
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Janssen, H. K., Stenull, O., and Oerding, K.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
We present a new view of Feynman diagrams for the field theory of transport on percolation clusters. The diagrams for random resistor networks are interpreted as being resistor networks themselves. This simplifies the field theory considerably as we demonstrate by calculating the fractal dimension $D_B$ of the percolation backbone to three loop order. Using renormalization group methods we obtain $D_B = 2 + \epsilon /21 - 172\epsilon^2 /9261 + 2 \epsilon^3 (- 74639 + 22680 \zeta (3))/4084101$, where $\epsilon = 6-d$ with $d$ being the spatial dimension and $\zeta (3) = 1.202057..$., Comment: 10 pages, 2 figures
- Published
- 1999
- Full Text
- View/download PDF
31. On Coupled Directed Percolation Processes: A Unifying View
- Author
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Janssen, H. K.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
It is shown that the universal critical properties of two recently introduced coupled directed percolation processes can be described by a single rapidity reversal invariant stochastic reaction-diffusion model. It is demonstrated that all renormalizations needed for the calculation of the universal scaling behavior near the multicritical point can be gained from the Gribov process (Reggeon field theory). Consequently the crossover exponent describing the scaling of the linear coupling parameter is given by Phi = 1 to all orders of the perturbation expansion., Comment: 6 pages, RevTeX
- Published
- 1999
32. Critical Exponents for Diluted Resistor Networks
- Author
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Stenull, O., Janssen, H. K., and Oerding, K.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
An approach by Stephen is used to investigate the critical properties of randomly diluted resistor networks near the percolation threshold by means of renormalized field theory. We reformulate an existing field theory by Harris and Lubensky. By a decomposition of the principal Feynman diagrams we obtain a type of diagrams which again can be interpreted as resistor networks. This new interpretation provides for an alternative way of evaluating the Feynman diagrams for random resistor networks. We calculate the resistance crossover exponent $\phi$ up to second order in $\epsilon=6-d$, where $d$ is the spatial dimension. Our result $\phi=1+\epsilon /42 +4\epsilon^2 /3087$ verifies a previous calculation by Lubensky and Wang, which itself was based on the Potts--model formulation of the random resistor network., Comment: 27 pages, 14 figures
- Published
- 1998
- Full Text
- View/download PDF
33. Qualification of piezo-electric actuators for the MADMAX booster system at cryogenic temperatures and high magnetic fields
- Author
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Garutti, E., primary, Janssen, H., additional, Kreikemeyer-Lorenzo, D., additional, Krieger, C., additional, Lindner, A., additional, Majorovits, B., additional, Schaffran, J., additional, and van Bree, B., additional
- Published
- 2023
- Full Text
- View/download PDF
34. Fast Fault Simulation to Identify Subcircuits Involving Faulty Components
- Author
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Tasić, B., Dohmen, J. J., ter Maten, E. J. W., Beelen, T. G. J., Janssen, H. H. J. M., Schilders, W. H. A., Günther, M., Bock, Hans Georg, Series editor, de Hoog, Frank, Series editor, Friedman, Avner, Series editor, Gupta, Arvind, Series editor, Nachbin, André, Series editor, Ozawa, Tohru, Series editor, Pulleyblank, William R., Series editor, Rusten, Torgeir, Series editor, Santosa, Fadil, Series editor, Seo, Jin Keun, Series editor, Tornberg, Anna-Karin, Series editor, Russo, Giovanni, editor, Capasso, Vincenzo, editor, Nicosia, Giuseppe, editor, and Romano, Vittorio, editor
- Published
- 2016
- Full Text
- View/download PDF
35. The European Project nanoCOPS for Nanoelectronic Coupled Problems Solutions
- Author
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Janssen, H. H. J. M., Benner, P., Bittner, K., Brachtendorf, H.-G., Feng, L., ter Maten, E. J. W., Pulch, R., Schoenmaker, W., Schöps, S., Tischendorf, C., Bock, Hans Georg, Series editor, de Hoog, Frank, Series editor, Friedman, Avner, Series editor, Gupta, Arvind, Series editor, Nachbin, André, Series editor, Ozawa, Tohru, Series editor, Pulleyblank, William R., Series editor, Rusten, Torgeir, Series editor, Santosa, Fadil, Series editor, Seo, Jin Keun, Series editor, Tornberg, Anna-Karin, Series editor, Russo, Giovanni, editor, Capasso, Vincenzo, editor, Nicosia, Giuseppe, editor, and Romano, Vittorio, editor
- Published
- 2016
- Full Text
- View/download PDF
36. Equation of state for directed percolation
- Author
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Janssen, H. K., Kutbay, Ue., and Oerding, K.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
Using field-theoretic renormalization group methods we calculate the equation of state for non-equilibrium systems belonging to the universality class of directed percolation (Gribov process) to second order in epsilon = 4-d. By introducing a parametric representation the result can be written to this order in a very simple form. We use our result to obtain a universal amplitude ratio to second order in epsilon., Comment: 12 pages, LaTeX (IOP style), 7 figures included
- Published
- 1998
- Full Text
- View/download PDF
37. Biased Diffusion with Correlated Noise
- Author
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Janssen, H. K. and Schmittmann, B.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
The diffusion of hard-core particles subject to a global bias is described by a nonlinear, anisotropic generalization of the diffusion equation with conserved, local noise. Using renormalization group techniques, we analyze the effect of an additional noise term, with spatially long-ranged correlations, on the long-time, long-wavelength behavior of this model. Above an upper critical dimension $d_{LR}$, the long-ranged noise is always relevant. In contrast, for $d
- Published
- 1998
- Full Text
- View/download PDF
38. Exact results for the Kardar--Parisi--Zhang equation with spatially correlated noise
- Author
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Janssen, H. K., Taeuber, U. C., and Frey, E.
- Subjects
Condensed Matter - Statistical Mechanics ,Condensed Matter - Disordered Systems and Neural Networks - Abstract
We investigate the Kardar--Parisi--Zhang (KPZ) equation in $d$ spatial dimensions with Gaussian spatially long--range correlated noise --- characterized by its second moment $R(\vec{x}-\vec{x}') \propto |\vec{x}-\vec{x}'|^{2\rho-d}$ --- by means of dynamic field theory and the renormalization group. Using a stochastic Cole--Hopf transformation we derive {\em exact} exponents and scaling functions for the roughening transition and the smooth phase above the lower critical dimension $d_c = 2 (1+\rho)$. Below the lower critical dimension, there is a line $\rho_*(d)$ marking the stability boundary between the short-range and long-range noise fixed points. For $\rho \geq \rho_*(d)$, the general structure of the renormalization-group equations fixes the values of the dynamic and roughness exponents exactly, whereas above $\rho_*(d)$, one has to rely on some perturbational techniques. We discuss the location of this stability boundary $\rho_* (d)$ in light of the exact results derived in this paper, and from results known in the literature. In particular, we conjecture that there might be two qualitatively different strong-coupling phases above and below the lower critical dimension, respectively., Comment: 21 pages, 15 figures
- Published
- 1998
- Full Text
- View/download PDF
39. Levy-flight spreading of epidemic processes leading to percolating clusters
- Author
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Janssen, H. K., Oerding, K., van Wijland, F., and Hilhorst, H. J.
- Subjects
Condensed Matter - Statistical Mechanics ,Quantitative Biology - Abstract
We consider two stochastic processes, the Gribov process and the general epidemic process, that describe the spreading of an infectious disease. In contrast to the usually assumed case of short-range infections that lead, at the critical point, to directed and isotropic percolation respectively, we consider long-range infections with a probability distribution decaying in d dimensions with the distance as 1/R^{d+\sigma}. By means of Wilson's momentum shell renormalization-group recursion relations, the critical exponents characterizing the growing fractal clusters are calculated to first order in an \epsilon-expansion. It is shown that the long-range critical behavior changes continuously to its short-range counterpart for a decay exponent of the infection \sigma =\sigma_c>2., Comment: 9 pages ReVTeX, 2 postscript figures included, submitted to Eur. Phys. J. B
- Published
- 1998
- Full Text
- View/download PDF
40. Influence of Long-range Interactions on the Critical Behavior of Systems with negative Fisher-Exponent
- Author
-
Janssen, H. K.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
The influence of long-range interactions decaying in d dimensions as 1/R^{d+\sigma} on the critical behavior of systems with Fisher's correlation-function exponent for short-range interactions \eta_{SR}<0, is re-examined. Such systems, typically described by \Phi ^{3}-field theories, are e.g. the Potts-model in the percolation-limit, the Edwards-Anderson spin-glass, and the Yang-Lee edge singularity. In contrast to preceding studies, it is shown by means of Wilson's momentum-shell renormalization-group recursion relations that the long-range interactions dominate as long as \sigma <2-\eta _{SR}. Exponents change continuously to their short-range values at the boundary of this region., Comment: 3pages, 2 figures
- Published
- 1998
- Full Text
- View/download PDF
41. Surface critical behavior of driven diffusive systems with open boundaries
- Author
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Oerding, K. and Janssen, H. K.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
Using field theoretic renormalization group methods we study the critical behavior of a driven diffusive system near a boundary perpendicular to the driving force. The boundary acts as a particle reservoir which is necessary to maintain the critical particle density in the bulk. The scaling behavior of correlation and response functions is governed by a new exponent eta_1 which is related to the anomalous scaling dimension of the chemical potential of the boundary. The new exponent and a universal amplitude ratio for the density profile are calculated at first order in epsilon = 5-d. Some of our results are checked by computer simulations., Comment: 10 pages ReVTeX, 6 figures included
- Published
- 1998
- Full Text
- View/download PDF
42. Omitting radiation therapy in women with triple-negative breast cancer leads to worse breast cancer-specific survival
- Author
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Kindts, I., Buelens, P., Laenen, A., Van Limbergen, E., Janssen, H., Wildiers, H., and Weltens, C.
- Published
- 2017
- Full Text
- View/download PDF
43. Joining of Thermoplastic Tapes with Metal Alloys Utilizing Novel Laser Sources and Enhanced Process Control in a Tape Placement Process
- Author
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Kukla, C., Peters, T., Janssen, H., and Brecher, C.
- Published
- 2017
- Full Text
- View/download PDF
44. Spontaneous Symmetry Breaking in Directed Percolation with Many Colors: Differentiation of Species in the Gribov Process
- Author
-
Janssen, H. K.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
A general field theoretic model of directed percolation with many colors that is equivalent to a population model (Gribov process) with many species near their extinction thresholds is presented. It is shown that the multicritical behavior is always described by the well known exponents of Reggeon field theory. In addition this universal model shows an instability that leads in general to a total asymmetry between each pair of species of a cooperative society., Comment: 4 pages, 2 Postscript figures, uses multicol.sty, submitted
- Published
- 1996
- Full Text
- View/download PDF
45. On Critical Exponents and the Renormalization of the Coupling Constant in Growth Models with Surface Diffusion
- Author
-
Janssen, H. K.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
It is shown by the method of renormalized field theory that in contrast to a statement based on a mathematically ill-defined invariance transformation and found in most of the recent publications on growth models with surface diffusion, the coupling constant of these models renormalizes nontrivially. This implies that the widely accepted supposedly exact scaling exponents are to be corrected. A two-loop calculation shows that the corrections are small and these exponents seem to be very good approximations., Comment: 4 pages, revtex, 2 postscript figures, to appear in Phys.Rev.Lett
- Published
- 1996
- Full Text
- View/download PDF
46. Renormalized field theory and particle density profile in driven diffusive systems with open boundaries
- Author
-
Janssen, H. K. and Oerding, K.
- Subjects
Condensed Matter - Abstract
We investigate the density profile in a driven diffusive system caused by a plane particle source perpendicular to the driving force. Focussing on the case of critical bulk density $\bar{c}$ we use a field theoretic renormalization group approach to calculate the density $c(z)$ as a function of the distance from the particle source at first order in $\epsilon=2-d$ ($d$: spatial dimension). For $d=1$ we find reasonable agreement with the exact solution recently obtained for the asymmetric exclusion model. Logarithmic corrections to the mean field profile are computed for $d=2$ with the result $c(z)-\bar{c} \sim z^{-1} (\ln(z))^{2/3}$ for $z \rightarrow \infty$., Comment: 32 pages, RevTex, 4 Postscript figures, to appear in Phys. Rev. E
- Published
- 1996
- Full Text
- View/download PDF
47. Slaap en slaapstoornissen
- Author
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Janssen, H. C. J. P., primary and Stapper, J. H. E. M., additional
- Published
- 2019
- Full Text
- View/download PDF
48. Greater Transplant-Free Survival in Patients Receiving Obeticholic Acid for Primary Biliary Cholangitis in a Clinical Trial Setting Compared to Real-World External Controls
- Author
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Murillo Perez, C, Fisher, H, Hiu, S, Kareithi, D, Adekunle, F, Mayne, T, Malecha, E, Ness, E, van der Meer, A, Lammers, W, Trivedi, P, Battezzati, P, Nevens, F, Kowdley, K, Bruns, T, Cazzagon, N, Floreani, A, Mason, A, Pares, A, Londono, M, Invernizzi, P, Carbone, M, Lleo, A, Mayo, M, Dalekos, G, Gatselis, N, Thorburn, D, Verhelst, X, Gulamhusein, A, Janssen, H, Smith, R, Flack, S, Mulcahy, V, Trauner, M, Bowlus, C, Lindor, K, Corpechot, C, Jones, D, Mells, G, Hirschfield, G, Wason, J, Hansen, B, Sturgess, R, Healey, C, Gunasekera, A, Kallis, Y, Wright, G, Mathialahan, T, Evans, R, Gasem, J, Ramanaden, D, Ward, E, Bhalme, M, Southern, P, Maggs, J, Yousif, M, Srivastava, B, Foxton, M, Collins, C, Prasad, Y, Porras-Perez, F, Yapp, T, Patel, M, Ede, R, Carte, M, Koss, K, Sattianayagam, P, Grimley, C, Tidbury, J, Mansour, D, Beckley, M, Hollywood, C, Ramag, J, Gordon, H, Ridpath, J, Grover, B, Abouda, G, Rees, I, Narain, M, Salam, I, Banim, P, Das, D, Matthews, H, Mohammed, F, Jones, R, Sen, S, Bird, G, Prince, M, Prasad, G, Kitchen, P, Hutchinson, J, Gupta, P, Shah, A, Saha, S, Pollock, K, Barclay, S, Mcdonald, N, Rushbrook, S, Przemioslo, R, Millar, A, Mitchell, S, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Cramp, M, Aspinal, R, Booth, J, Williams, E, Hussaini, H, Christie, J, Chaudhry, T, Mann, S, Ala, A, Maltby, J, Corbett, C, Singhal, S, Hoeroldt, B, Butterworth, J, Douglas, A, Sinha, R, Panter, S, Shearman, J, Bray, G, Roberts, M, Forton, D, Taylor, N, Jafar, W, Cowan, M, Ch'Ng, C, Rahman, M, Wesley, E, Jain, S, Mandal, A, Wright, M, Gordon, F, Unitt, E, Austin, A, Palegwala, A, Vemala, V, Higham, A, Fraser, J, Li, A, Ramakrishnan, S, King, A, Whalley, S, Gee, I, Keld, R, Fellows, H, Gotto, J, Millson, C, Murillo Perez C. F., Fisher H., Hiu S., Kareithi D., Adekunle F., Mayne T., Malecha E., Ness E., van der Meer A. J., Lammers W. J., Trivedi P. J., Battezzati P. M., Nevens F., Kowdley K. V., Bruns T., Cazzagon N., Floreani A., Mason A. L., Pares A., Londono M. -C., Invernizzi P., Carbone M., Lleo A., Mayo M. J., Dalekos G. N., Gatselis N. K., Thorburn D., Verhelst X., Gulamhusein A., Janssen H. L. A., Smith R., Flack S., Mulcahy V., Trauner M., Bowlus C. L., Lindor K. D., Corpechot C., Jones D., Mells G., Hirschfield G. M., Wason J., Hansen B. E., Sturgess R., Healey C., Gunasekera A., Kallis Y., Wright G., Mathialahan T., Evans R., Gasem J., Ramanaden D., Ward E., Bhalme M., Southern P., Maggs J., Yousif M., Srivastava B., Foxton M., Collins C., Prasad Y., Porras-Perez F., Yapp T., Patel M., Ede R., Carte M., Koss K., Sattianayagam P., Grimley C., Tidbury J., Mansour D., Beckley M., Hollywood C., Ramag J., Gordon H., Ridpath J., Grover B., Abouda G., Rees I., Narain M., Salam I., Banim P., Das D., Matthews H., Mohammed F., Jones R., Sen S., Bird G., Prince M., Prasad G., Kitchen P., Hutchinson J., Gupta P., Shah A., Saha S., Pollock K., Barclay S., McDonald N., Rushbrook S., Przemioslo R., Millar A., Mitchell S., Davis A., Naqvi A., Lee T., Ryder S., Collier J., Cramp M., Aspinal R., Booth J., Williams E., Hussaini H., Christie J., Chaudhry T., Mann S., Ala A., Maltby J., Corbett C., Singhal S., Hoeroldt B., Butterworth J., Douglas A., Sinha R., Panter S., Shearman J., Bray G., Roberts M., Forton D., Taylor N., Jafar W., Cowan M., Ch'ng C. L., Rahman M., Wesley E., Jain S., Mandal A., Wright M., Trivedi P., Gordon F., Unitt E., Austin A., Palegwala A., Vemala V., Higham A., Fraser J., Li A., Ramakrishnan S., King A., Whalley S., Gee I., Keld R., Fellows H., Gotto J., Millson C., Murillo Perez, C, Fisher, H, Hiu, S, Kareithi, D, Adekunle, F, Mayne, T, Malecha, E, Ness, E, van der Meer, A, Lammers, W, Trivedi, P, Battezzati, P, Nevens, F, Kowdley, K, Bruns, T, Cazzagon, N, Floreani, A, Mason, A, Pares, A, Londono, M, Invernizzi, P, Carbone, M, Lleo, A, Mayo, M, Dalekos, G, Gatselis, N, Thorburn, D, Verhelst, X, Gulamhusein, A, Janssen, H, Smith, R, Flack, S, Mulcahy, V, Trauner, M, Bowlus, C, Lindor, K, Corpechot, C, Jones, D, Mells, G, Hirschfield, G, Wason, J, Hansen, B, Sturgess, R, Healey, C, Gunasekera, A, Kallis, Y, Wright, G, Mathialahan, T, Evans, R, Gasem, J, Ramanaden, D, Ward, E, Bhalme, M, Southern, P, Maggs, J, Yousif, M, Srivastava, B, Foxton, M, Collins, C, Prasad, Y, Porras-Perez, F, Yapp, T, Patel, M, Ede, R, Carte, M, Koss, K, Sattianayagam, P, Grimley, C, Tidbury, J, Mansour, D, Beckley, M, Hollywood, C, Ramag, J, Gordon, H, Ridpath, J, Grover, B, Abouda, G, Rees, I, Narain, M, Salam, I, Banim, P, Das, D, Matthews, H, Mohammed, F, Jones, R, Sen, S, Bird, G, Prince, M, Prasad, G, Kitchen, P, Hutchinson, J, Gupta, P, Shah, A, Saha, S, Pollock, K, Barclay, S, Mcdonald, N, Rushbrook, S, Przemioslo, R, Millar, A, Mitchell, S, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Cramp, M, Aspinal, R, Booth, J, Williams, E, Hussaini, H, Christie, J, Chaudhry, T, Mann, S, Ala, A, Maltby, J, Corbett, C, Singhal, S, Hoeroldt, B, Butterworth, J, Douglas, A, Sinha, R, Panter, S, Shearman, J, Bray, G, Roberts, M, Forton, D, Taylor, N, Jafar, W, Cowan, M, Ch'Ng, C, Rahman, M, Wesley, E, Jain, S, Mandal, A, Wright, M, Gordon, F, Unitt, E, Austin, A, Palegwala, A, Vemala, V, Higham, A, Fraser, J, Li, A, Ramakrishnan, S, King, A, Whalley, S, Gee, I, Keld, R, Fellows, H, Gotto, J, Millson, C, Murillo Perez C. F., Fisher H., Hiu S., Kareithi D., Adekunle F., Mayne T., Malecha E., Ness E., van der Meer A. J., Lammers W. J., Trivedi P. J., Battezzati P. M., Nevens F., Kowdley K. V., Bruns T., Cazzagon N., Floreani A., Mason A. L., Pares A., Londono M. -C., Invernizzi P., Carbone M., Lleo A., Mayo M. J., Dalekos G. N., Gatselis N. K., Thorburn D., Verhelst X., Gulamhusein A., Janssen H. L. A., Smith R., Flack S., Mulcahy V., Trauner M., Bowlus C. L., Lindor K. D., Corpechot C., Jones D., Mells G., Hirschfield G. M., Wason J., Hansen B. E., Sturgess R., Healey C., Gunasekera A., Kallis Y., Wright G., Mathialahan T., Evans R., Gasem J., Ramanaden D., Ward E., Bhalme M., Southern P., Maggs J., Yousif M., Srivastava B., Foxton M., Collins C., Prasad Y., Porras-Perez F., Yapp T., Patel M., Ede R., Carte M., Koss K., Sattianayagam P., Grimley C., Tidbury J., Mansour D., Beckley M., Hollywood C., Ramag J., Gordon H., Ridpath J., Grover B., Abouda G., Rees I., Narain M., Salam I., Banim P., Das D., Matthews H., Mohammed F., Jones R., Sen S., Bird G., Prince M., Prasad G., Kitchen P., Hutchinson J., Gupta P., Shah A., Saha S., Pollock K., Barclay S., McDonald N., Rushbrook S., Przemioslo R., Millar A., Mitchell S., Davis A., Naqvi A., Lee T., Ryder S., Collier J., Cramp M., Aspinal R., Booth J., Williams E., Hussaini H., Christie J., Chaudhry T., Mann S., Ala A., Maltby J., Corbett C., Singhal S., Hoeroldt B., Butterworth J., Douglas A., Sinha R., Panter S., Shearman J., Bray G., Roberts M., Forton D., Taylor N., Jafar W., Cowan M., Ch'ng C. L., Rahman M., Wesley E., Jain S., Mandal A., Wright M., Trivedi P., Gordon F., Unitt E., Austin A., Palegwala A., Vemala V., Higham A., Fraser J., Li A., Ramakrishnan S., King A., Whalley S., Gee I., Keld R., Fellows H., Gotto J., and Millson C.
- Abstract
Background & Aims: The Primary Biliary Cholangitis (PBC) Obeticholic Acid (OCA) International Study of Efficacy (POISE) randomized, double-blind, placebo-controlled trial demonstrated that OCA reduced biomarkers associated with adverse clinical outcomes (ie, alkaline phosphatase, bilirubin, aspartate aminotransferase, and alanine aminotransferase) in patients with PBC. The objective of this study was to evaluate time to first occurrence of liver transplantation or death in patients with OCA in the POISE trial and open-label extension vs comparable non-OCA–treated external controls. Methods: Propensity scores were generated for external control patients meeting POISE eligibility criteria from 2 registry studies (Global PBC and UK-PBC) using an index date selected randomly between the first and last date (inclusive) on which eligibility criteria were met. Cox proportional hazards models weighted by inverse probability of treatment assessed time to death or liver transplantation. Additional analyses (Global PBC only) added hepatic decompensation to the composite end point and assessed efficacy in patients with or without cirrhosis. Results: During the 6-year follow-up, there were 5 deaths or liver transplantations in 209 subjects in the POISE cohort (2.4%), 135 of 1381 patients in the Global PBC control (10.0%), and 281 of 2135 patients in the UK-PBC control (13.2%). The hazard ratios (HRs) for the primary outcome were 0.29 (95% CI, 0.10–0.83) for POISE vs Global PBC and 0.30 (95% CI, 0.12–0.75) for POISE vs UK-PBC. In the Global PBC study, HR was 0.20 (95% CI, 0.03–1.22) for patients with cirrhosis and 0.31 (95% CI, 0.09–1.04) for those without cirrhosis; HR was 0.42 (95% CI, 0.21–0.85) including hepatic decompensation. Conclusions: Patients treated with OCA in a trial setting had significantly greater transplant-free survival than comparable external control patients.
- Published
- 2022
49. Modelling some aspects of the monocyclic phase of Stemphylium vesicarium, the pathogen causing purple spot on asparagus (Asparagus officinalis L.)
- Author
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Bohlen-Janssen, H., Racca, P., Hau, B., and Wichura, A.
- Published
- 2018
- Full Text
- View/download PDF
50. Emotional and non-emotional mental imagery and auditory verbal hallucinations (hearing voices): A systematic review of imagery assessment tools
- Author
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Janssen, H., Berg, K.C. van den, Paulik, G., Newman-Taylor, K., Taylor, C.D.J., Steel, C., Keijsers, G.P.J., Marcelis, M.C., Janssen, H., Berg, K.C. van den, Paulik, G., Newman-Taylor, K., Taylor, C.D.J., Steel, C., Keijsers, G.P.J., and Marcelis, M.C.
- Abstract
Item does not contain fulltext, It is unknown to what extent mental imagery and auditory verbal hallucinations (AVHs) are related. Trials evaluating this issue used both emotional and non-emotional mental imagery tools, thereby complicating outcomes comparisons. Therefore, the present study aimed to systematically review the literature on mental imagery in individuals with AVHs to (1) inventory imagery assessment tools used in this population, (2) to collect information on the relation between emotional and non-emotional mental imagery in all sensory domains and AVHs and (3) to integrate the outcomes of this systematic review in a model of different mental imagery domains and related assessment tools. We conducted a systematic literature search in the PubMed Database. After full-text screening, 17 papers were included. Findings showed that a variety of assessment methods have been used to assess various aspects of mental imagery in people with AVHs, suggesting that there is a lack of agreed theoretical conceptualization of mental imagery and AVHs. In addition, the studies confirmed as was expected that non-emotional mental imagery seemed unrelated to AVHs whereas emotional mental imagery was related to AVHs. Lastly, we proposed a model of mental imagery domains and corresponding assessment methods distinguishing between emotional and non-emotional mental imagery., 31 oktober 2023, 14 p.
- Published
- 2023
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