1. Persistent organic pollutants (POPs) in human follicular fluid and in vitro fertilization outcomes, a pilot study.
- Author
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Bloom MS, Fujimoto VY, Storm R, Zhang L, Butts CD, Sollohub D, and Jansing RL
- Subjects
- DDT toxicity, Dichlorodiphenyl Dichloroethylene toxicity, Embryo Implantation drug effects, Environmental Pollutants toxicity, Female, Humans, Multivariate Analysis, Pilot Projects, Polychlorinated Biphenyls toxicity, Predictive Value of Tests, Pregnancy, Pregnancy Outcome epidemiology, DDT analysis, Dichlorodiphenyl Dichloroethylene analysis, Environmental Pollutants analysis, Fertilization in Vitro, Follicular Fluid chemistry, Polychlorinated Biphenyls analysis
- Abstract
Persistent organic pollutants (POPs) are ubiquitously distributed among the U.S. population and adversely impact human reproduction. These compounds have been detected in human ovarian follicular fluid (FF), where they directly contact a developing oocyte. As a pilot investigation, we measured 43 polychlorinated biphenyl (PCB) congeners, p,p'-dichlorodiphenyltrichloroethane (DDT), and its persistent metabolite p,p'-dichlorodiphenyldichloroethylene (DDE) in residual FF collected from 32 women undergoing in vitro fertilization (IVF). We identified significant inverse associations between higher levels of PCB congeners and indicators of ovarian reserve (e.g., antral follicle count), follicular response to administered gonadotropins (e.g., peak estradiol, number of oocytes retrieved, endometrial thickness), intermediate IVF endpoints (e.g., oocyte fertilization and embryo quality), and clinical IVF outcomes (e.g., embryo implantation and live birth), after adjusting for body mass index, cigarette smoking, race, and age. Our results suggest that ongoing exposure to POPs impacts IVF and merit confirmation in a larger and more definitive future study., (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Published
- 2017
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