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4. Quantitative CT of the knee in the IMI-APPROACH osteoarthritis cohort: Association of bone mineral density with radiographic disease severity, meniscal coverage and meniscal extrusion

Author

Heiss, Rafael, Laredo, Jean-Denis, Wirth, Wolfgang, Jansen, Mylène P., Marijnissen, Anne C.A., Lafeber, Floris, Lalande, Agnes, Weinans, Harrie H., Blanco, Francisco J., Berenbaum, Francis, Kloppenburg, Margreet, Haugen, Ida K., Engelke, Klaus, and Roemer, Frank W.

Published
2023
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5. Effects of Knee Flexion on Minimal Joint Space Width Increase in Knee Osteoarthritis Patients in the IMI-APPROACH cohort

Author

Bax, Eva, primary, Nguyen, Chien, additional, Custers, Roel J., additional, van Egmond, Nienke, additional, Arbabi, Vahid, additional, Rayegan, Hassan, additional, Paul Gielis, Willem, additional, Lindner, Claudia, additional, Cootes, Tim, additional, Kloppenburg, Margreet, additional, Blanco-Garcia, Francisco J, additional, Haugen, Ida K., additional, Berenbaum, Francis, additional, Jansen, Mylène P., additional, Mastbergen, Simon, additional, Wirth, Wolfgang, additional, Eckstein, Felix, additional, and Weinans, Harrie, additional

Published
2024
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6. Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort

Author

Roemer, Frank W., Jansen, Mylène, Marijnissen, Anne C. A., Guermazi, Ali, Heiss, Rafael, Maschek, Susanne, Lalande, Agnes, Blanco, Francisco J., Berenbaum, Francis, van de Stadt, Lotte A., Kloppenburg, Margreet, Haugen, Ida K., Ladel, Christoph H., Bacardit, Jaume, Wisser, Anna, Eckstein, Felix, Lafeber, Floris P. J. G., Weinans, Harrie H., and Wirth, Wolfgang

Published
2022
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8. Severity and progression of structural hand OA is not associated with progression of structural knee OA: The IMI-APPROACH cohort

Author

MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Regenerative Medicine and Stem Cells, ORT Research, Lab Reumatologie/Klinische Immunologie, Terpstra, Sietse E S, van de Stadt, Lotte A, Berenbaum, Francis, Blanco, Francisco J, Haugen, Ida K, Mastbergen, Simon C, Weinans, Harrie, Jansen, Mylène P, Rosendaal, Frits R, Kloppenburg, Margreet, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Regenerative Medicine and Stem Cells, ORT Research, Lab Reumatologie/Klinische Immunologie, Terpstra, Sietse E S, van de Stadt, Lotte A, Berenbaum, Francis, Blanco, Francisco J, Haugen, Ida K, Mastbergen, Simon C, Weinans, Harrie, Jansen, Mylène P, Rosendaal, Frits R, and Kloppenburg, Margreet

Published
2024

9. Erratum: Return to Sport and Work after Randomization for Knee Distraction versus High Tibial Osteotomy: Is There a Difference? (Journal of Knee Surgery DOI: 10.1055/s-0040-1721027)

Author

MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Regenerative Medicine and Stem Cells, Lab Reumatologie/Klinische Immunologie, Hoorntje, Alexander, Kuijer, P. Paul F.M., Koenraadt, Koen L.M., Waterval-Witjes, Suzanne, Kerkhoffs, Gino M.M.J., Mastbergen, Simon C., Marijnissen, Anne C.A., Jansen, Mylène P., van Geenen, Rutger C.I., MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Regenerative Medicine and Stem Cells, Lab Reumatologie/Klinische Immunologie, Hoorntje, Alexander, Kuijer, P. Paul F.M., Koenraadt, Koen L.M., Waterval-Witjes, Suzanne, Kerkhoffs, Gino M.M.J., Mastbergen, Simon C., Marijnissen, Anne C.A., Jansen, Mylène P., and van Geenen, Rutger C.I.

Published
2024

10. Increased vascular inflammation on PET/CT in psoriatic arthritis patients in comparison with controls

Author

Unit Opleiding Reumat./Klin. Immunologie, Infection & Immunity, MS Reumatologie/Immunologie/Infectie, MS Medische Oncologie, Cancer, Lab Reumatologie/Klinische Immunologie, Regenerative Medicine and Stem Cells, Researchgr. Systems Radiology, Circulatory Health, MS Radiologie, Kleinrensink, Nienke J, Spierings, Julia, Vonkeman, Harald E, Seddiqi, Negina, Herman, Amin, Suijkerbuijk, Karijn P M, Heijstek, Marloes W, Jansen, Mylène P, de Jong, Pim A, Foppen, Wouter, Unit Opleiding Reumat./Klin. Immunologie, Infection & Immunity, MS Reumatologie/Immunologie/Infectie, MS Medische Oncologie, Cancer, Lab Reumatologie/Klinische Immunologie, Regenerative Medicine and Stem Cells, Researchgr. Systems Radiology, Circulatory Health, MS Radiologie, Kleinrensink, Nienke J, Spierings, Julia, Vonkeman, Harald E, Seddiqi, Negina, Herman, Amin, Suijkerbuijk, Karijn P M, Heijstek, Marloes W, Jansen, Mylène P, de Jong, Pim A, and Foppen, Wouter

Published
2024

11. Can gait patterns be explained by joint structure in people with and without radiographic knee osteoarthritis?: data from the IMI-APPROACH cohort

Author

Jansen, Mylène P., Hodgins, Diana, Mastbergen, Simon C., Kloppenburg, Margreet, Blanco García, Francisco J, Haugen, Ida K., Berenbaum, Francis, Eckstein, Felix, Roemer, Frank W., Wirt, Wolfgang, Jansen, Mylène P., Hodgins, Diana, Mastbergen, Simon C., Kloppenburg, Margreet, Blanco García, Francisco J, Haugen, Ida K., Berenbaum, Francis, Eckstein, Felix, Roemer, Frank W., and Wirt, Wolfgang

Abstract

[Abstract] Objective: To determine the association between joint structure and gait in patients with knee osteoarthritis (OA). Methods: IMI-APPROACH recruited 297 clinical knee OA patients. Gait data was collected (GaitSmart®) and OA-related joint measures determined from knee radiographs (KIDA) and MRIs (qMRI/MOAKS). Patients were divided into those with/without radiographic OA (ROA). Principal component analyses (PCA) were performed on gait parameters; linear regression models were used to evaluate whether image-based structural and demographic parameters were associated with gait principal components. Results: Two hundred seventy-one patients (age median 68.0, BMI 27.0, 77% female) could be analyzed; 149 (55%) had ROA. PCA identified two components: upper leg (primarily walking speed, stride duration, hip range of motion [ROM], thigh ROM) and lower leg (calf ROM, knee ROM in swing and stance phases). Increased age, BMI, and radiographic subchondral bone density (sclerosis), decreased radiographic varus angle deviation, and female sex were statistically significantly associated with worse lower leg gait (i.e. reduced ROM) in patients without ROA (R2 = 0.24); in ROA patients, increased BMI, radiographic osteophytes, MRI meniscal extrusion and female sex showed significantly worse lower leg gait (R2 = 0.18). Higher BMI was significantly associated with reduced upper leg function for non-ROA patients (R2 = 0.05); ROA patients with male sex, higher BMI and less MRI synovitis showed significantly worse upper leg gait (R2 = 0.12). Conclusion: Structural OA pathology was significantly associated with gait in patients with clinical knee OA, though BMI may be more important. While associations were not strong, these results provide a significant association between OA symptoms (gait) and joint structure.

Published
2024

18. Structural changes after ankle joint distraction in haemophilic arthropathy: an explorative study investigating biochemical markers and 3D joint space width

Author

van Bergen, Eline D. P., primary, Mastbergen, Simon C., additional, Lafeber, Floris P. J. G., additional, Bay‐Jensen, Anne‐Christine, additional, Madsen, Sofie F., additional, Port, Helena, additional, Foppen, Wouter, additional, Schutgens, Roger E. G., additional, Jansen, Mylène P., additional, and van Vulpen, Lize F. D., additional

Published
2023
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19. Identifying multivariate disease trajectories and potential phenotypes of early knee osteoarthritis in the CHECK cohort

Author

Altamirano, Sara, Jansen, Mylène P, Oberski, Daniel L, Eijkemans, Marinus J C, Mastbergen, Simon C, Lafeber, Floris P J G, van Spil, Willem E, Welsing, Paco M J, Altamirano, Sara, Jansen, Mylène P, Oberski, Daniel L, Eijkemans, Marinus J C, Mastbergen, Simon C, Lafeber, Floris P J G, van Spil, Willem E, and Welsing, Paco M J

Abstract

OBJECTIVE: To gain better understanding of osteoarthritis (OA) heterogeneity and its predictors for distinguishing OA phenotypes. This could provide the opportunity to tailor prevention and treatment strategies and thus improve care.DESIGN: Ten year follow-up data from CHECK (1002 early-OA subjects with first general practitioner visit for complaints ≤6 months before inclusion) was used. Data were collected on WOMAC (pain, function, stiffness), quantitative radiographic tibiofemoral (TF) OA characteristics, and semi-quantitative radiographic patellofemoral (PF) OA characteristics. Using functional data analysis, distinctive sets of trajectories were identified for WOMAC, TF and PF characteristics, based on model fit and clinical interpretation. The probabilities of knee membership to each trajectory were used in hierarchical cluster analyses to derive knee OA phenotypes. The number and composition of potential phenotypes was selected again based on model fit (silhouette score) and clinical interpretation.RESULTS: Five trajectories representing different constant levels or changing WOMAC scores were identified. For TF and PF OA, eight and six trajectories respectively were identified based on (changes in) joint space narrowing, osteophytes and sclerosis. Combining the probabilities of knees belonging to these different trajectories resulted in six clusters ('phenotypes') of knees with different degrees of functional (WOMAC) and radiographic (PF) parameters; TF parameters were found not to significantly contribute to clustering. Including baseline characteristics as well resulted in eight clusters of knees, dominated by sex, menopausal status and WOMAC scores, with only limited contribution of PF features.CONCLUSIONS: Several stable and progressive trajectories of OA symptoms and radiographic features were identified, resulting in phenotypes with relatively independent symptomatic and radiographic features. Sex and menopausal status may be espe

Published
2023

20. Identifying multivariate disease trajectories and potential phenotypes of early knee osteoarthritis in the CHECK cohort

Author

Leerstoel Oberski, Methodology and statistics for the behavioural and social sciences, Altamirano, Sara, Jansen, Mylène P, Oberski, Daniel L, Eijkemans, Marinus J C, Mastbergen, Simon C, Lafeber, Floris P J G, van Spil, Willem E, Welsing, Paco M J, Leerstoel Oberski, Methodology and statistics for the behavioural and social sciences, Altamirano, Sara, Jansen, Mylène P, Oberski, Daniel L, Eijkemans, Marinus J C, Mastbergen, Simon C, Lafeber, Floris P J G, van Spil, Willem E, and Welsing, Paco M J

Published
2023

21. Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort

Author

Jansen, Mylène P., Wirth, Wolfgang, Bacardit, Jaume, van Helvoort, Eefje M., Marijnissen, Anne C.A., Kloppenburg, Margreet, Blanco García, Francico J, Haugen, Ida K., Berenbaum, Francis, Ladel, Christoph H., Loef, Marieke, Lafeber, Floris P.J.G., Welsing, Paco M.J., Mastbergen, Simon C., Roemer, Frank W., Jansen, Mylène P., Wirth, Wolfgang, Bacardit, Jaume, van Helvoort, Eefje M., Marijnissen, Anne C.A., Kloppenburg, Margreet, Blanco García, Francico J, Haugen, Ida K., Berenbaum, Francis, Ladel, Christoph H., Loef, Marieke, Lafeber, Floris P.J.G., Welsing, Paco M.J., Mastbergen, Simon C., and Roemer, Frank W.

Abstract

[Abstract] In the Innovative Medicine’s Initiative Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) knee osteoarthritis (OA) study, machine learning models were trained to predict the probability of structural progression (s-score), predefined as >0.3 mm/year joint space width (JSW) decrease and used as inclusion criterion. The current objective was to evaluate predicted and observed structural progression over 2 years according to different radiographic and magnetic resonance imaging (MRI)-based structural parameters. Radiographs and MRI scans were acquired at baseline and 2-year follow-up. Radiographic (JSW, subchondral bone density, osteophytes), MRI quantitative (cartilage thickness), and MRI semiquantitative [SQ; cartilage damage, bone marrow lesions (BMLs), osteophytes] measurements were obtained. The number of progressors was calculated based on a change exceeding the smallest detectable change (SDC) for quantitative measures or a full SQ-score increase in any feature. Prediction of structural progression based on baseline s-scores and Kellgren-Lawrence (KL) grades was analyzed using logistic regression. Among 237 participants, around 1 in 6 participants was a structural progressor based on the predefined JSW-threshold. The highest progression rate was seen for radiographic bone density (39%), MRI cartilage thickness (38%), and radiographic osteophyte size (35%). Baseline s-scores could only predict JSW progression parameters (most P>0.05), while KL grades could predict progression of most MRI-based and radiographic parameters (P<0.05). In conclusion, between 1/6 and 1/3 of participants showed structural progression during 2-year follow-up. KL scores were observed to outperform the machine-learning-based s-scores as progression predictor. The large amount of data collected, and the wide range of disease stage, can be used for further development of more sensitive and successful (whole joint) prediction models.

Published
2023

22. Identifying multivariate disease trajectories and potential phenotypes of early knee osteoarthritis in the CHECK cohort

Author

Onderzoek Reumatologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Datascience, Circulatory Health, Biostatistiek Onderzoek, MS Reumatologie/Immunologie/Infectie, Lab Reumatologie/Klinische Immunologie, JC onderzoeksprogramma Methodologie, Altamirano, Sara, Jansen, Mylène P., Oberski, Daniel L., Eijkemans, Marinus J.C., Mastbergen, Simon C., Lafeber, Floris P.J.G., van Spil, Willem E., Welsing, Paco M.J., Onderzoek Reumatologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Datascience, Circulatory Health, Biostatistiek Onderzoek, MS Reumatologie/Immunologie/Infectie, Lab Reumatologie/Klinische Immunologie, JC onderzoeksprogramma Methodologie, Altamirano, Sara, Jansen, Mylène P., Oberski, Daniel L., Eijkemans, Marinus J.C., Mastbergen, Simon C., Lafeber, Floris P.J.G., van Spil, Willem E., and Welsing, Paco M.J.

Published
2023

23. Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort

Author

Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Onderzoek Reumatologie, MS Reumatologie/Immunologie/Infectie, JC onderzoeksprogramma Methodologie, Jansen, Mylène P., Wirth, Wolfgang, Bacardit, Jaume, van Helvoort, Eefje M., Marijnissen, Anne C.A., Kloppenburg, Margreet, Blanco, Francisco J., Haugen, Ida K., Berenbaum, Francis, Ladel, Cristoph H., Loef, Marieke, Lafeber, Floris P.J.G., Welsing, Paco M., Mastbergen, Simon C., Roemer, Frank W., Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Onderzoek Reumatologie, MS Reumatologie/Immunologie/Infectie, JC onderzoeksprogramma Methodologie, Jansen, Mylène P., Wirth, Wolfgang, Bacardit, Jaume, van Helvoort, Eefje M., Marijnissen, Anne C.A., Kloppenburg, Margreet, Blanco, Francisco J., Haugen, Ida K., Berenbaum, Francis, Ladel, Cristoph H., Loef, Marieke, Lafeber, Floris P.J.G., Welsing, Paco M., Mastbergen, Simon C., and Roemer, Frank W.

Published
2023

24. Relevance of Biomarkers in Serum vs. Synovial Fluid in Patients with Knee Osteoarthritis

Author

Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Onderzoek Reumatologie, MS Reumatologie/Immunologie/Infectie, Kalogera, Stefania, Jansen, Mylène P., Bay-Jensen, Anne Christine, Frederiksen, Peder, Karsdal, Morten A., Thudium, Christian S., Mastbergen, Simon C., Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Onderzoek Reumatologie, MS Reumatologie/Immunologie/Infectie, Kalogera, Stefania, Jansen, Mylène P., Bay-Jensen, Anne Christine, Frederiksen, Peder, Karsdal, Morten A., Thudium, Christian S., and Mastbergen, Simon C.

Published
2023

25. Structural changes after ankle joint distraction in haemophilic arthropathy: an explorative study investigating biochemical markers and 3D joint space width

Author

Poli Van Creveldkliniek Medisch, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Regenerative Medicine and Stem Cells, Lab Reumatologie/Klinische Immunologie, MS Radiologie, Child Health, Circulatory Health, Onderzoek Reumatologie, van Bergen, Eline D P, Mastbergen, Simon C, Lafeber, Floris P J G, Bay-Jensen, Anne-Christine, Madsen, Sofie F, Port, Helena, Foppen, Wouter, Schutgens, Roger E G, Jansen, Mylène P, van Vulpen, Lize F D, Poli Van Creveldkliniek Medisch, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Regenerative Medicine and Stem Cells, Lab Reumatologie/Klinische Immunologie, MS Radiologie, Child Health, Circulatory Health, Onderzoek Reumatologie, van Bergen, Eline D P, Mastbergen, Simon C, Lafeber, Floris P J G, Bay-Jensen, Anne-Christine, Madsen, Sofie F, Port, Helena, Foppen, Wouter, Schutgens, Roger E G, Jansen, Mylène P, and van Vulpen, Lize F D

Published
2023

26. Joint distraction using a purpose-built device for knee osteoarthritis: A prospective 2-year follow-up

Author

Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Onderzoek Reumatologie, MS Reumatologie/Immunologie/Infectie, Regenerative Medicine and Stem Cells, MS Orthopaedie Algemeen, Struik, Thijmen, Mastbergen, Simon C., Brouwer, Reinoud W., Custers, Roel J.H., Van Geenen, Rutger C.I., Heusdens, Christiaan H.W., Emans, Pieter J., Huizinga, Maarten R., Jansen, Mylène P., Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Onderzoek Reumatologie, MS Reumatologie/Immunologie/Infectie, Regenerative Medicine and Stem Cells, MS Orthopaedie Algemeen, Struik, Thijmen, Mastbergen, Simon C., Brouwer, Reinoud W., Custers, Roel J.H., Van Geenen, Rutger C.I., Heusdens, Christiaan H.W., Emans, Pieter J., Huizinga, Maarten R., and Jansen, Mylène P.

Published
2023

27. Exploring the differences between radiographic joint space width and MRI cartilage thickness changes using data from the IMI-APPROACH cohort

Author

Onderzoek Reumatologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Lab Reumatologie/Klinische Immunologie, MS Reumatologie/Immunologie/Infectie, JC onderzoeksprogramma Methodologie, Jansen, Mylène P., Roemer, Frank W., Marijnissen, Anne Karien C.A., Kloppenburg, Margreet, Blanco, Francisco J., Haugen, Ida K., Berenbaum, Francis, Lafeber, Floris P.J.G., Welsing, Paco M.J., Mastbergen, Simon C., Wirth, Wolfgang, Onderzoek Reumatologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Lab Reumatologie/Klinische Immunologie, MS Reumatologie/Immunologie/Infectie, JC onderzoeksprogramma Methodologie, Jansen, Mylène P., Roemer, Frank W., Marijnissen, Anne Karien C.A., Kloppenburg, Margreet, Blanco, Francisco J., Haugen, Ida K., Berenbaum, Francis, Lafeber, Floris P.J.G., Welsing, Paco M.J., Mastbergen, Simon C., and Wirth, Wolfgang

Published
2023

28. Artificial intelligence in osteoarthritis: Repair by knee joint distraction shows association of pain, radiographic and immunological outcomes

Author

Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Onderzoek Reumatologie, MS Orthopaedie Algemeen, MS Reumatologie/Immunologie/Infectie, Jansen, Mylène P., Salzlechner, Christoph, Barnes, Eleanor, Difranco, Matthew D., Custers, Roel J.H., Watt, Fiona E., Vincent, Tonia L., Mastbergen, Simon C., Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Onderzoek Reumatologie, MS Orthopaedie Algemeen, MS Reumatologie/Immunologie/Infectie, Jansen, Mylène P., Salzlechner, Christoph, Barnes, Eleanor, Difranco, Matthew D., Custers, Roel J.H., Watt, Fiona E., Vincent, Tonia L., and Mastbergen, Simon C.

Published
2023

29. Quantitative CT of the knee in the IMI-APPROACH osteoarthritis cohort: Association of bone mineral density with radiographic disease severity, meniscal coverage and meniscal extrusion

Author

Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, ORT Research, Heiss, Rafael, Laredo, Jean-Denis, Wirth, Wolfgang, Jansen, Mylène P, Marijnissen, Anne C A, Lafeber, Floris, Lalande, Agnes, Weinans, Harrie H, Blanco, Francisco J, Berenbaum, Francis, Kloppenburg, Margreet, Haugen, Ida K, Engelke, Klaus, Roemer, Frank W, Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, ORT Research, Heiss, Rafael, Laredo, Jean-Denis, Wirth, Wolfgang, Jansen, Mylène P, Marijnissen, Anne C A, Lafeber, Floris, Lalande, Agnes, Weinans, Harrie H, Blanco, Francisco J, Berenbaum, Francis, Kloppenburg, Margreet, Haugen, Ida K, Engelke, Klaus, and Roemer, Frank W

Published
2023

30. Predicted and actual 2-year structural and pain progression in the IMI-APPROACH knee osteoarthritis cohort

Author

Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, ORT Research, JC onderzoeksprogramma Methodology, van Helvoort, Eefje M, Jansen, Mylène P, Marijnissen, Anne C A, Kloppenburg, Margreet, Blanco, Francisco J, Haugen, Ida K, Berenbaum, Francis, Bay-Jensen, Anne-Christine C, Ladel, Christoph, Lalande, Agnes, Larkin, Jonathan, Loughlin, John, Mobasheri, Ali, Weinans, Harrie H, Widera, Pawel, Bacardit, Jaume, Welsing, Paco M J, Lafeber, Floris P J G, Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, ORT Research, JC onderzoeksprogramma Methodology, van Helvoort, Eefje M, Jansen, Mylène P, Marijnissen, Anne C A, Kloppenburg, Margreet, Blanco, Francisco J, Haugen, Ida K, Berenbaum, Francis, Bay-Jensen, Anne-Christine C, Ladel, Christoph, Lalande, Agnes, Larkin, Jonathan, Loughlin, John, Mobasheri, Ali, Weinans, Harrie H, Widera, Pawel, Bacardit, Jaume, Welsing, Paco M J, and Lafeber, Floris P J G

Published
2023

31. Relevance of Biomarkers in Serum vs. Synovial Fluid in Patients with Knee Osteoarthritis

Author

Kalogera, Stefania, Jansen, Mylène P., Bay-Jensen, Anne-Christine, Frederiksen, Peder, Karsdal, Morten A., Thudium, Christian S., Mastbergen, Simon C., Kalogera, Stefania, Jansen, Mylène P., Bay-Jensen, Anne-Christine, Frederiksen, Peder, Karsdal, Morten A., Thudium, Christian S., and Mastbergen, Simon C.

Abstract

The association between structural changes and pain sensation in osteoarthritis (OA) remains unclear. Joint deterioration in OA leads to the release of protein fragments that can either systemically (serum) or locally (synovial fluid; SF) be targeted as biomarkers and describe structural changes and potentially pain. Biomarkers of collagen type I (C1M), type II (C2M), type III (C3M), type X (C10C), and aggrecan (ARGS) degradation were measured in the serum and SF of knee OA patients. Spearman’s rank correlation was used to assess the correlation of the biomarkers’ levels between serum and SF. Linear regression adjusted for confounders was used to evaluate the associations between the biomarkers’ levels and clinical outcomes. The serum C1M levels were negatively associated with subchondral bone density. The serum C2M levels were negatively associated with KL grade and positively associated with minimum joint space width (minJSW). The C10C levels in SF were negatively associated with minJSW and positively associated with KL grade and osteophyte area. Lastly, the serum C2M and C3M levels were negatively associated with pain outcomes. Most of the biomarkers seemed to mainly be associated with structural outcomes. The overall biomarkers of extracellular matrix (ECM) remodeling in serum and SF may provide different information and reflect different pathogenic processes.

Published
2023

32. Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort

Author

Jansen, Mylène P., primary, Wirth, Wolfgang, additional, Bacardit, Jaume, additional, van Helvoort, Eefje M., additional, Marijnissen, Anne C. A., additional, Kloppenburg, Margreet, additional, Blanco, Francisco J., additional, Haugen, Ida K., additional, Berenbaum, Francis, additional, Ladel, Cristoph H., additional, Loef, Marieke, additional, Lafeber, Floris P. J. G., additional, Welsing, Paco M., additional, Mastbergen, Simon C., additional, and Roemer, Frank W., additional

Published
2023
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34. Artificial intelligence in osteoarthritis: repair by knee joint distraction shows association of pain, radiographic and immunological outcomes.

Author

Jansen, Mylène P, Salzlechner, Christoph, Barnes, Eleanor, DiFranco, Matthew D, Custers, Roel J H, Watt, Fiona E, Vincent, Tonia L, and Mastbergen, Simon C

Subjects
*KNEE radiography, *BIOMARKERS, *TOTAL knee replacement, *PAIN measurement, *ARTIFICIAL intelligence, *REGRESSION analysis, *TREATMENT effectiveness, *PRE-tests & post-tests, *IMMUNOASSAY, *OSTEOARTHRITIS, *IMMUNITY, *RESEARCH funding, *SYNOVIAL fluid
Abstract

Objectives Knee joint distraction (KJD) has been associated with clinical and structural improvement and SF marker changes. The current objective was to analyse radiographic changes after KJD using an automatic artificial intelligence-based measurement method and relate these to clinical outcome and SF markers. Methods Twenty knee osteoarthritis patients were treated with KJD in regular care. Radiographs and WOMAC were collected before and ∼1 year post-treatment. SF was aspirated before, during and after treatment; biomarker levels were assessed by immunoassay. Radiographs were analysed to obtain compartmental minimum and standardized joint space width (JSW), Kellgren–Lawrence (KL) grades, compartmental joint space narrowing (JSN) scores, and osteophytosis and sclerosis scores. Results were analysed for the most affected compartment (MAC) and least affected compartment. Radiographic changes were analysed using the Wilcoxon signed rank test for categorical and paired t -test for continuous variables. Linear regression was used to calculate associations between changes in JSW, WOMAC pain and SF markers. Results Sixteen patients could be evaluated. JSW, KL and JSN improved in around half of the patients, significant only for MAC JSW (P  < 0.05). MAC JSW change was positively associated with WOMAC pain change (P  < 0.04). Greater monocyte chemoattractant protein 1 (MCP-1) and lower TGFβ-1 increases were significantly associated with changes in MAC JSW (P  < 0.05). MCP-1 changes were positively associated with WOMAC pain changes (P  < 0.05). Conclusion Automatic radiographic measurements show improved joint structure in most patients after KJD in regular care. MAC JSW increased significantly and was associated with SF biomarker level changes and even with improvements in pain as experienced by these patients. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Knee joint distraction results in MRI cartilage thickness increase up to 10 years after treatment

Author

Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Jansen, Mylène P, Mastbergen, Simon C, MacKay, James W, Turmezei, Tom D, Lafeber, Floris, Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Jansen, Mylène P, Mastbergen, Simon C, MacKay, James W, Turmezei, Tom D, and Lafeber, Floris

Published
2022

37. Return to Sport and Work after Randomization for Knee Distraction versus High Tibial Osteotomy: Is There a Difference?

Author

Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Hoorntje, Alexander, Kuijer, P Paul F M, Koenraadt, Koen L M, Waterval-Witjes, Suzanne, Kerkhoffs, Gino M M J, Mastbergen, Simon C, Marijnissen, Anne C A, Jansen, Mylène P, van Geenen, Rutger C I, Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Hoorntje, Alexander, Kuijer, P Paul F M, Koenraadt, Koen L M, Waterval-Witjes, Suzanne, Kerkhoffs, Gino M M J, Mastbergen, Simon C, Marijnissen, Anne C A, Jansen, Mylène P, and van Geenen, Rutger C I

Published
2022

38. Predicted and actual 2-year structural and pain progression in the IMI-APPROACH knee osteoarthritis cohort

Author

van Helvoort, Eefje M, primary, Jansen, Mylène P, additional, Marijnissen, Anne C A, additional, Kloppenburg, Margreet, additional, Blanco, Francisco J, additional, Haugen, Ida K, additional, Berenbaum, Francis, additional, Bay-Jensen, Anne-Christine C, additional, Ladel, Christoph, additional, Lalande, Agnes, additional, Larkin, Jonathan, additional, Loughlin, John, additional, Mobasheri, Ali, additional, Weinans, Harrie H, additional, Widera, Pawel, additional, Bacardit, Jaume, additional, Welsing, Paco M J, additional, and Lafeber, Floris P J G, additional

Published
2022
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44. LB-067 - Effects of Knee Flexion on Minimal Joint Space Width Increase in Knee Osteoarthritis Patients in the IMI-APPROACH cohort.

Author

Bax, Eva, Nguyen, Chien, Custers, Roel J., van Egmond, Nienke, Arbabi, Vahid, Rayegan, Hassan, Paul Gielis, Willem, Lindner, Claudia, Cootes, Tim, Kloppenburg, Margreet, Blanco-Garcia, Francisco J, Haugen, Ida K., Berenbaum, Francis, Jansen, Mylène P., Mastbergen, Simon, Wirth, Wolfgang, Eckstein, Felix, and Weinans, Harrie

Published
2024
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45. Neuropathic pain in the IMI-APPROACH knee osteoarthritis cohort: prevalence and phenotyping

Author

van Helvoort, Eefje Martine, primary, Welsing, Paco M J, additional, Jansen, Mylène P, additional, Gielis, Willem Paul, additional, Loef, Marieke, additional, Kloppenburg, Margreet, additional, Blanco, Francisco, additional, Haugen, Ida K, additional, Berenbaum, Francis, additional, Bay-Jensen, Anne-C, additional, Ladel, Christoph, additional, Lalande, Agnes, additional, Larkin, Jonathan, additional, Loughlin, John, additional, Mobasheri, Ali, additional, Weinans, Harrie, additional, Lafeber, Floris, additional, Eijkelkamp, Niels, additional, and Mastbergen, Simon, additional

Published
2021
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46. Predicted and actual 2-year structural and pain progression in the IMI-APPROACH knee osteoarthritis cohort.

Author

Helvoort, Eefje M van, Jansen, Mylène P, Marijnissen, Anne C A, Kloppenburg, Margreet, Blanco, Francisco J, Haugen, Ida K, Berenbaum, Francis, Bay-Jensen, Anne-Christine C, Ladel, Christoph, Lalande, Agnes, Larkin, Jonathan, Loughlin, John, Mobasheri, Ali, Weinans, Harrie H, Widera, Pawel, Bacardit, Jaume, Welsing, Paco M J, and Lafeber, Floris P J G

Subjects
*KNEE osteoarthritis, *DISEASE progression, *EXPERIMENTAL design, *BIOMARKERS, *PAIN, *PAIN measurement, *TIME, *MACHINE learning, *REGRESSION analysis, *JOINT pain, *QUESTIONNAIRES, *DESCRIPTIVE statistics, *RECEIVER operating characteristic curves, *PREDICTION models, *DATA analysis software, *LONGITUDINAL method
Abstract

Objectives The IMI-APPROACH knee osteoarthritis study used machine learning (ML) to predict structural and/or pain progression, expressed by a structural (S) and pain (P) predicted-progression score, to select patients from existing cohorts. This study evaluates the actual 2-year progression within the IMI-APPROACH, in relation to the predicted-progression scores. Methods Actual structural progression was measured using minimum joint space width (minJSW). Actual pain (progression) was evaluated using the Knee injury and Osteoarthritis Outcomes Score (KOOS) pain questionnaire. Progression was presented as actual change (Δ) after 2 years, and as progression over 2 years based on a per patient fitted regression line using 0, 0.5, 1 and 2-year values. Differences in predicted-progression scores between actual progressors and non-progressors were evaluated. Receiver operating characteristic (ROC) curves were constructed and corresponding area under the curve (AUC) reported. Using Youden's index, optimal cut-offs were chosen to enable evaluation of both predicted-progression scores to identify actual progressors. Results Actual structural progressors were initially assigned higher S predicted-progression scores compared with structural non-progressors. Likewise, actual pain progressors were assigned higher P predicted-progression scores compared with pain non-progressors. The AUC-ROC for the S predicted-progression score to identify actual structural progressors was poor (0.612 and 0.599 for Δ and regression minJSW, respectively). The AUC-ROC for the P predicted-progression score to identify actual pain progressors were good (0.817 and 0.830 for Δ and regression KOOS pain, respectively). Conclusion The S and P predicted-progression scores as provided by the ML models developed and used for the selection of IMI-APPROACH patients were to some degree able to distinguish between actual progressors and non-progressors. Trial registration ClinicalTrials.gov, https://clinicaltrials.gov , NCT03883568. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Erratum: Return to sport and work after randomization for knee distraction versus high tibial osteotomy: Is there a difference (J Knee Surg (2021) 00 (1) DOI: 10.1055/s-0040-1721027)

Author

Hoorntje, Alexander, Kuijer, P Paul F M, Koenraadt, Koen L M, Waterval-Witjes, Suzanne, Kerkhoffs, Gino M M J, Mastbergen, Simon C, Marijnissen, Anne C A, Jansen, Mylène P, van Geenen, Rutger C I, Graduate School, APH - Quality of Care, CCA - Cancer Treatment and Quality of Life, APH - Societal Participation & Health, Amsterdam Movement Sciences, Public and occupational health, AMS - Musculoskeletal Health, AMS - Sports, Orthopedic Surgery and Sports Medicine, and AMS - Ageing & Vitality

Abstract

It has been brought to the publisher s attention that the two subparts A and B of Figure 5 were inadvertently swapped in the article with DOI: 10.1055/s-0040-1721027 published on November 23, 2020. The corrected figure appears as follows. (Figure Presented).

Published
2021

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