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2. P1078 The influence of different 5-aminosalicylic acid preparations on mercaptopurine metabolism

Author

Anjie, S, primary, Hettinga, J, additional, Volkers, A G, additional, van Gennep, S, additional, Clasquin, E, additional, Duijvestein, M, additional, van Bodegraven, A A, additional, van der Zanden, E P, additional, Jansen, J M, additional, van Asseldonk, D P, additional, West, R L, additional, D'Haens, G R A M, additional, Löwenberg, M, additional, and de Boer, N K, additional

Published
2024
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4. Dynamic Resource and Task Management

Author

Klinik, M., Jansen, J. M., Bolderheij, F., Oonincx, Patrick J., Editor-in-Chief, de Pee-Vencken, F., Managing Editor, Monsuur, H., editor, Jansen, J.M., editor, and Marchal, F.J., editor

Published
2018
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5. Efeito do Tempo de Doença na Biomecânica Respiratória de Pacientes Portadores de Artrite Reumatóide

Author

Faria, A. C. D., Lopes, A. J., Jansen, J. M., Pinheiro, G. R. C., Melo, P. L., Folgueras Méndez, José, editor, Aznielle Rodríguez, Tania Y., editor, Calderón Marín, Carlos F., editor, Llanusa Ruiz, Susana Beatriz, editor, Castro Medina, Jorge, editor, Vega Vázquez, Haddid, editor, Carballo Barreda, Maylen, editor, and Rodríguez Rojas, Rafael, editor

Published
2013
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6. Validação da Técnica de Oscilações Forçadas no Diagnóstico das Alterações Respiratórias em Pacientes com Silicose

Author

Sá, P. M., Lopes, A. J., Jansen, J. M., Melo, P. L., Folgueras Méndez, José, editor, Aznielle Rodríguez, Tania Y., editor, Calderón Marín, Carlos F., editor, Llanusa Ruiz, Susana Beatriz, editor, Castro Medina, Jorge, editor, Vega Vázquez, Haddid, editor, Carballo Barreda, Maylen, editor, and Rodríguez Rojas, Rafael, editor

Published
2013
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11. Smoking is Associated with Higher Disease-related Costs and Lower Health-related Quality of Life in Inflammatory Bowel Disease

Author

Severs, M., Mangen, M-J. J., van der Valk, M. E., Fidder, H. H., Dijkstra, G., van der Have, M., van Bodegraven, A. A., de Jong, D. J., van der Woude, C. J., Romberg-Camps, M. J. L., Clemens, C. H. M., Jansen, J. M., van de Meeberg, P. C., Mahmmod, N., Ponsioen, C. Y., Vermeijden, J. R., van der Meulen- de Jong, A. E., Pierik, M., Siersema, P. D., and Oldenburg, B.

Published
2017
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13. Smoking is Associated With Extra-intestinal Manifestations in Inflammatory Bowel Disease

Author

Severs, M., van Erp, S. J. H., van der Valk, M. E., Mangen, M. J. J., Fidder, H. H., van der Have, M., van Bodegraven, A. A., de Jong, D. J., van der Woude, C. J., Romberg-Camps, M. J. L., Clemens, C. H. M., Jansen, J. M., van de Meeberg, P. C., Mahmmod, N., Ponsioen, C. Y., Bolwerk, C., Vermeijden, J. R., Pierik, M. J., Siersema, P. D., Leenders, M., van der Meulen-de Jong, A. E., Dijkstra, G., and Oldenburg, B.

Published
2016
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14. DOP75 Effectiveness and Safety of tofacitinib versus vedolizumab in Patients with Ulcerative Colitis; A Nationwide, ICC Registry study

Author

Straatmijer, T, primary, Visschedijk, M, additional, de Vries, A, additional, Hoentjen, F, additional, van Bodegraven, A A, additional, Bodelier, A G L, additional, de Boer, N K H, additional, Dijkstra, G, additional, Festen, E A M, additional, Horjus, C, additional, Jansen, J M, additional, Jharap, B, additional, Mares, W, additional, Oldenburg, B, additional, Ponsioen, C Y, additional, Romkens, T E H, additional, Srivastava, N, additional, van der Voorn, M M, additional, West, R L, additional, van der Woude, J C, additional, Wolvers, M D J, additional, Pierik, M, additional, van der Meulen, A E, additional, and Duijvestein, M, additional

Published
2022
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17. P286 Ustekinumab for Crohn’s Disease: Two-Year Results of the Initiative on Crohn and Colitis (ICC) Registry, a Nationwide Prospective Observational Cohort Study

Author

Straatmijer, T, primary, Biemans, V B C, additional, Hoentjen, F, additional, de Boer, N K H, additional, Bodelier, A G, additional, Dijkstra, G, additional, van Dop, W, additional, Haans, J J L, additional, Jansen, J M, additional, Maljaars, P W J, additional, van der Marel, S, additional, Oldenburg, B, additional, Ponsioen, C Y, additional, Visschedijk, M C, additional, de Vries, A C, additional, West, R, additional, van der Woude, C J, additional, Pierik, M, additional, Duijvestein, M, additional, and van der Meulen- de Jong, A E, additional

Published
2021
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26. Abstracts of lectures and posters pharmaceutical and biomedical analysis meeting

Author

Ackermans, Mariëtte, Endert, Erik, Aluoch, J., Ouintens, I., Roets, E., Hoogmartens, J., Barka, G., Opper, C., Kerkdijk, H., Witte, D. T., Bruggeman, F. J., Franke, J. P., Copinga, S., Jansen, J. M., de Zeeuw, R. A., Bosman, I. J., Ensing, K., Dekker, I., Dams, Ir. A. B. J. M., de Pooter, Ch. M. J., Fichtinger-Schepman, A. M. J., Scalliet, P. G., Maes, R. A., Berends, F., Van Oosterom, A. T., de Bruijn, E. A., Fay, L. A., Verstappen, C. J., Pluijms, W., Irth, H., Oosterkamp, A. J., van der Welle, W., Khan, K., Paesen, J., Jacobs, Peter L., de Vries, Marcel P., Lammers, Norbert, Biermans, Frans, de Witte, Eric, Mussche, Philippe, Lamoree, M. H., Reinhoud, N. J., Tjaden, U. R., Niessen, W. M. A., van der Greef, J., Solie, A., Paulus, Aran, Klockow, Antje, Bruin, Gerard J. M., Reubsaet, J. L. E., Beijnen, J. H., Bult, A., Teeuwsen, J., Koster, E. H. M., Waterval, J. C. M., Underberg, W. J. M., Cypers, W., Claeys, P., Simonian, M. H., Rongen, Herman A. H., van der Horst, Helma M., Bult, Auke, van Bennekom, Wout P., Šmisterová, J., Thoithi, G., Van Schepdael, A., Wouters, K., Herdewijn, P., Vendrig, D., Gout, E., van Santvoort, P. M. J., Hamelinck, R. L. A. E., van Zeeland, M. J. M., Janssen, P. S. L., Vervoort, R. J. M., Derksen, M. W. J., Maris, F. A., Yongxin, Zhu, Hendrix, C., Busson, R., and Janssen, G.

Published
1994
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27. Abstracts of papers

Author

Vermeulen., Nico P. E., den Kelder, G. M. Donné-Op, Commandeur, Jan N. M., Kaspcrsen, F. M., Bessems, Jos G. M., te Koppele, Johan M., van Dijk, Patricia A., Vermeulen, Nico P. E., Brakenhoff, Jan P. G., Wormhoudt, Lars W., Groot, Ed J., Caldirola, P., Bijloo, G. J., Mannhold, R., Coats, E., Timmerman, H., Ching, T. L., Haenen, G. R. M. M., Bast, A., Christiaans, J. A. M., Windhorst, A. D., Groenenberg, P. M., van der Goot, H., de Rooij, Ben M., Rijksen, Désirée A., Boogaard, Peter J., van Sittert, Nico J., Drijfhout, W. J., Grol, C. J., Westerink, B. H. C., Eriks, J. Ch., Fischer, M. J. E., Paulussen, J. J. C., Horbach, D. A., Roelofsen, E. P. W., de Mol, N. J., Janssen, L. H. M., Hermans, J. J. R., Thijssen, H. H. W., Jansen, J. M., Karlén, A., Hacksell, U., Maliepaard, M., Sitters, C. A. M. C., Menge, W. M. P. B., van Rhee, A. M., van Winden, E. C. A., Nagelkerke, J. F., de Bont, H. J. G. M., Ijzerman, A. P., Soudijn, W., Van Veldhuizen, M. J. A., Feenstra, M. G. P., Boer, G. J., Vleeming, W., Riezebos, J., van Amsterdam, J. G. C., Wemer, J., de Wildt, D. J., Porsius, A. J., Vree, T. B., van Ewijk-Beneken Kolmer, E. W. J., van den Biggelaar-Martea, M., van Wissen-Verwey, C. P. W. G. M., Broekman, M. M. M., Zhang, M. Q., and Leysen, D. C.

Published
1993
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29. DOP58 Tofacitinib for ulcerative colitis: Results of the ICC Registry, a nationwide prospective observational cohort study

Author

Biemans, V B, primary, Sleutjes, J A M, additional, de Vries, A C, additional, Bodelier, A G, additional, Dijkstra, G, additional, Oldenburg, B, additional, Löwenberg, M, additional, van Bodegraven, A A, additional, van der Meulen-de Jong, A E, additional, de Boer, N K, additional, Srivastava, N, additional, West, R L, additional, Römkens, T, additional, Horjus Talabur Horje, C S, additional, Jansen, J M, additional, Hoekstra, J, additional, Weersma, R K, additional, van Schaik, F D, additional, Hoentjen, F, additional, and Pierik, M J, additional

Published
2020
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31. Increased Discontinuation Rates of Anti-TNF Therapy in Elderly Inflammatory Bowel Disease Patients.

Author

Jong, M E de, Smits, L J T, Ruijven, B van, Broeder, N den, Russel, M G V M, Römkens, T E H, West, R L, Jansen, J M, and Hoentjen, F

Abstract

Background and Aims There is paucity of data on safety and efficacy of anti-tumour necrosis factor [TNF] in elderly inflammatory bowel disease [IBD] patients. We aimed to compare the long-term treatment failure rates and safety of a first anti-TNF agent in IBD patients between different age groups [<40 years/40–59 years/≥60 years]. Methods IBD patients who started a first anti-TNF agent were identified through IBDREAM, a multicentre prospective IBD registry. Competing risk regression was used to study treatment failure, defined as time to drug discontinuation due to adverse events [AEs] or lack of effectiveness, with discontinuation due to remission as a competing risk. Results A total of 895 IBD patients were included; 546 started anti-TNF at age <40 [61.0%], 268 at age 40–59 [29.9%], and 81 at age ≥60 [9.1%]. Treatment failure rate was higher in the two older groups (subhazard rate [SHR] age ≥60 1.46, SHR age 40–59 1.21; p  = 0.03). The SHR in the elderly [>60] was 1.52 for discontinuation due to AEs and 1.11 for lack of effectiveness. Concomitant thiopurine use was associated with a lower treatment failure rate (SHR 0.78, 95% confidence interval [CI] 0.62–0.98, p  = 0.031). Serious adverse event [SAE] rate, as well as serious infection rate, were significantly higher in elderly IBD patients [61.2 versus 16.0 and 12.4 per 1000 patient-years, respectively] whereas the malignancy rate was low in all age groups. Conclusions Elderly IBD patients starting a first anti-TNF agent showed higher treatment failure rates, but concomitant thiopurine use at baseline was associated with lower failure rates. Elderly IBD patients demonstrated higher rates of SAEs and serious infections. [ABSTRACT FROM AUTHOR]

Published
2020
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32. Emerging Technologies in Instrumentation and Controls

Author

Wood, R. T., primary, Antonescu, C. E., additional, Arndt, S. A., additional, Britton, C. L., additional, Brown-VanHoozer, S. A., additional, Calvert, J. A., additional, Damiano, B., additional, Easter, J. R., additional, Freer, E. B., additional, Hardy, J. E., additional, Hively, L. M., additional, Holcomb, D. E., additional, Jansen, J. M., additional, Kisner, R. A., additional, Korsah, K., additional, Miller, D. W., additional, Moore, M. R., additional, Mullens, J. A., additional, Neal, J. S., additional, Protopopescu, V. A., additional, Shaffer, R. A., additional, Schryver, J. C., additional, Smith, C. M., additional, Tucker, R. W., additional, Uhrig, R. E., additional, Upadhyaya, B. R., additional, Wetherington, G. R., additional, Wilson, T. L., additional, White, J. D., additional, and Whitus, B. R., additional

Published
2003
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34. Smoking is Associated with Higher Disease-related Costs and Lower Health-related Quality of Life in Inflammatory Bowel Disease

Author

UMC Utrecht, Unit Opleiding Aios, Cancer, HEE, MS MDL 1, Infection & Immunity, Severs, M., Mangen, M. J.J., van der Valk, M. E., Fidder, H. H., Dijkstra, G., van der Have, M., Van Bodegraven, Ad A., de Jong, J., van der Woude, C Janneke, Romberg-Camps, Mariëlle J L, Clemens, C. H. M., Jansen, J. M., van de Meeberg, Paul C, Mahmmod, N., Ponsioen, Cyriel Y, Vermeijden, Jacob R., Van der Meulen-de Jong, Andrea E, Pierik, M., Siersema, P. D., Oldenburg, B., COIN study group and the Dutch Initiative on Crohn and Colitis, UMC Utrecht, Unit Opleiding Aios, Cancer, HEE, MS MDL 1, Infection & Immunity, Severs, M., Mangen, M. J.J., van der Valk, M. E., Fidder, H. H., Dijkstra, G., van der Have, M., Van Bodegraven, Ad A., de Jong, J., van der Woude, C Janneke, Romberg-Camps, Mariëlle J L, Clemens, C. H. M., Jansen, J. M., van de Meeberg, Paul C, Mahmmod, N., Ponsioen, Cyriel Y, Vermeijden, Jacob R., Van der Meulen-de Jong, Andrea E, Pierik, M., Siersema, P. D., Oldenburg, B., and COIN study group and the Dutch Initiative on Crohn and Colitis

Published
2017

35. Smoking is associated with extra-intestinal manifestations in inflammatory bowel disease

Author

MS MDL 1, Cancer, HTA Onderzoek Team 1, JC onderzoeksprogramma Infectieziekten, Circulatory Health, JC onderzoeksprogramma Methodologie, Infection & Immunity, Unit Opleiding Aios, Severs, M., van Erp, S. J H, van der Valk, M. E., Mangen, M. J J, Fidder, H. H., van der Have, M., van Bodegraven, A. A., de Jong, D. J., van der Woude, C. J., Romberg-Camps, M. J L, Clemens, C. H M, Jansen, J. M, van de Meeberg, P. C., Mahmmod, N., Ponsioen, C. Y., Bolwerkm, C., Vermeijden, J. R., Pierik, M. J., Siersema, P. D., Leenders, M., van der Meulen-de Jong, A. E., Dijkstra, G., Oldenburg, Bas, MS MDL 1, Cancer, HTA Onderzoek Team 1, JC onderzoeksprogramma Infectieziekten, Circulatory Health, JC onderzoeksprogramma Methodologie, Infection & Immunity, Unit Opleiding Aios, Severs, M., van Erp, S. J H, van der Valk, M. E., Mangen, M. J J, Fidder, H. H., van der Have, M., van Bodegraven, A. A., de Jong, D. J., van der Woude, C. J., Romberg-Camps, M. J L, Clemens, C. H M, Jansen, J. M, van de Meeberg, P. C., Mahmmod, N., Ponsioen, C. Y., Bolwerkm, C., Vermeijden, J. R., Pierik, M. J., Siersema, P. D., Leenders, M., van der Meulen-de Jong, A. E., Dijkstra, G., and Oldenburg, Bas

Published
2016

36. Smoking is associated with extra-intestinal manifestations in inflammatory bowel disease

Author

Severs, M., van Erp, S., Dijkstra, G., van der Valk, M. E., Mangen, M. -J., van der Have, M., van Bodegraven, A. A., Fidder, H. H., de Jong, D. J., Pierik, M., van der Woude, J, Romberg-Camps, M. J. L., Clemens, C. H. M., Jansen, J M, van de Meeberg, P. C., Mahmmod, N., Ponsioen, C. Y., Bolwerk, C. J., Vermeijden, J. R., Siersema, P. D., Leenders, M., van der Meulen-de Jong, A. E., Oldenburg, B., Severs, M., van Erp, S., Dijkstra, G., van der Valk, M. E., Mangen, M. -J., van der Have, M., van Bodegraven, A. A., Fidder, H. H., de Jong, D. J., Pierik, M., van der Woude, J, Romberg-Camps, M. J. L., Clemens, C. H. M., Jansen, J M, van de Meeberg, P. C., Mahmmod, N., Ponsioen, C. Y., Bolwerk, C. J., Vermeijden, J. R., Siersema, P. D., Leenders, M., van der Meulen-de Jong, A. E., and Oldenburg, B.

Published
2015

37. Smoking is associated with extra-intestinal manifestations in inflammatory bowel disease

Author

MS MDL 1, Cancer, HTA Onderzoek Team 1, JC onderzoeksprogramma Infectious Diseases, JC onderzoeksprogramma Methodology, Unit Opleiding Aios, Infection & Immunity, Severs, M., van Erp, S., Dijkstra, G., van der Valk, M. E., Mangen, M. -J., van der Have, M., van Bodegraven, A. A., Fidder, H. H., de Jong, D. J., Pierik, M., van der Woude, J, Romberg-Camps, M. J. L., Clemens, C. H. M., Jansen, J M, van de Meeberg, P. C., Mahmmod, N., Ponsioen, C. Y., Bolwerk, C. J., Vermeijden, J. R., Siersema, P. D., Leenders, M., van der Meulen-de Jong, A. E., Oldenburg, B., MS MDL 1, Cancer, HTA Onderzoek Team 1, JC onderzoeksprogramma Infectious Diseases, JC onderzoeksprogramma Methodology, Unit Opleiding Aios, Infection & Immunity, Severs, M., van Erp, S., Dijkstra, G., van der Valk, M. E., Mangen, M. -J., van der Have, M., van Bodegraven, A. A., Fidder, H. H., de Jong, D. J., Pierik, M., van der Woude, J, Romberg-Camps, M. J. L., Clemens, C. H. M., Jansen, J M, van de Meeberg, P. C., Mahmmod, N., Ponsioen, C. Y., Bolwerk, C. J., Vermeijden, J. R., Siersema, P. D., Leenders, M., van der Meulen-de Jong, A. E., and Oldenburg, B.

Published
2015

38. Smoking is Associated With Extra-intestinal Manifestations in Inflammatory Bowel Disease

Author

Severs, M., primary, van Erp, S. J. H., additional, van der Valk, M. E., additional, Mangen, M. J. J., additional, Fidder, H. H., additional, van der Have, M., additional, van Bodegraven, A. A., additional, de Jong, D. J., additional, van der Woude, C. J., additional, Romberg-Camps, M. J. L., additional, Clemens, C. H. M., additional, Jansen, J. M., additional, van de Meeberg, P. C., additional, Mahmmod, N., additional, Ponsioen, C. Y., additional, Bolwerk, C., additional, Vermeijden, J. R., additional, Pierik, M. J., additional, Siersema, P. D., additional, Leenders, M., additional, van der Meulen-de Jong, A. E., additional, Dijkstra, G., additional, and Oldenburg, B., additional

Published
2015
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39. Behandeling van recidiverende Clostridium dificile-geassocieerde diarree met een suspensie van donorfeces

Author

Nieuwdorp, M., van Nood, E., Speelman, P., van Heukelem, H. A., Jansen, J. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Keller, J. J., Vascular Medicine, Other departments, Amsterdam institute for Infection and Immunity, Infectious diseases, Medical Microbiology and Infection Prevention, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, and Gastroenterology and Hepatology

Abstract

OBJECTIVE: To study the effect of treating recurrent Clostridium difficile-associated diarrhoea (CDAD) with a suspension of donor faeces. DESIGN: Uncontrolled interventional study. METHOD: Patients that, despite adequate antibiotic therapy, had developed at least 2 recurrences ofCDAD, including at least one recurrence that had been treated with a vancomycin tapering regimen, were included in the study. Relatives or volunteers served as faeces donor. All donors were previously examined for the presence of HIV, hepatitis B- and C-virus, and acute infection with cytomegalovirus or Epstein-Barr virus. The donor faeces were examined for the presence of C. difficile, Yersinia, Campylobacter, Shigella, Salmonella, and parasites. Before the infusion of donor faeces, the patients were treated for 4 days with vancomycin 500 mg q.i.d., followed by colon lavage. The suspension of 150 g of donor faeces dissolved in 300-400 ml of NaCl was infused into the jejunum via a duodenal catheter or into the caecum via colonoscopy. RESULTS: 7 CDAD patients were included and treated, including 2 with the hypervirulent C. difficile-strain PCR ribotype 027, toxinotype III. In 5 patients, the defaecation frequency returned to normal almost immediately after treatment and the cultures and toxin tests for C. difficile were repeatedly negative. In the remaining 2 patients, the treatment was successful after a repeated infusion of faeces from a different donor. CONCLUSION: Treatment with donor faeces seems promising for patients who develop repeated recurrences despite adequate therapy and could be valuable in the future during (local) epidemics of the PCR ribotype 027 strain. A randomised nationwide study (FECAL trial) has been started in order to determine the efficacy of this treatment

Published
2008

40. A GUIDING FRAMEWORK FOR THE DEVELOPMENT OF A TRANS-DISCIPLINARY COMMUNITY MENTAL HEALTH STUDENT TEACHING AND LEARNING PLATFORM.

Author

Jansen, J. M., Preez, M. du, Exner, R., and Stroud, L.

Subjects
STUDENT teaching, TEACHING methods, EDUCATIONAL cooperation, SOCIAL justice, LEARNING management
Abstract

Establishing a trans-disciplinary mental health platform could contribute to outreach and service training agendas in a higher educational context as engagement is a higher education priority for all universities. The purpose of the platform described in the article provides an opportunity for students to learn from each other, with each other and about each other, across a variety of disciplines in one university, while also effectively addressing the needs of the surrounding community. This article records the background to the establishment of a unique multi-disciplinary university-community collaborative initiative in South Africa by using a self-reflective and participatory action learning and action research approach which is learner centred, project-based, and aimed at social justice. Indeed, transformative teaching has been one of the teaching methodologies which has guided this initiative. Furthermore, this student, teaching and learning platform also identifies lessons learnt and creates a guiding framework for the establishment of similar projects in other communities. First, and most importantly, this platform contributes to providing a framework to guide and encourage future establishments of similar universitycommunity collaborative engagement endeavours and, secondly, it highlights the requirements for sustaining services to communities when senior students exit their university programmes, and new students enter. [ABSTRACT FROM AUTHOR]

Published
2017
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41. Oncological outcome of malignant colonic obstruction in the Dutch Stent-In 2 trial

Author

Sloothaak, D A M, primary, van den Berg, M W, additional, Dijkgraaf, M G W, additional, Fockens, P, additional, Tanis, P J, additional, van Hooft, J E, additional, Bemelman, W A, additional, Dijkgraaf, M G, additional, Sprangers, M A, additional, Buskens, C J, additional, Jansen, J M, additional, Gerhards, M F, additional, Timmer, R, additional, van Ramshorst, B, additional, Oldenburg, B, additional, van Hilligersberg, R, additional, Bakker, C M, additional, Sosef, M, additional, Witteman, P, additional, Kruyt, P, additional, ten Hove, W R, additional, Tseng, L N, additional, van der Linde, K, additional, Koopal, S A, additional, Marinelli, A W, additional, Perk, L, additional, Lutke Holzik, M F, additional, Grubben, M J, additional, Heisterkamp, J, additional, Depla, A C, additional, Derksen, E, additional, Naber, A H, additional, van Geloven, A A, additional, Breumelhof, R, additional, Davids, P H, additional, Akol, H, additional, van der Zaag, E, additional, Schenk, E, additional, Patijn, G A, additional, Veenendaal, R A, additional, Tollenaar, R A, additional, van Berkel, A, additional, Gilissen, L P, additional, Nieuwenhuijzen, G A, additional, van der Waaij, L A, additional, Baas, P C, additional, Cense, H, additional, Scholten, P, additional, van Wagensveld, B, additional, Koornstra, J J, additional, Havenga, K, additional, van Milligen de Wit, M, additional, Rijken, A M, additional, Cazemier, M, additional, Guicherit, O R, additional, Houben, M H, additional, and Steup, W H, additional

Published
2014
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49. Análise da Mecânica Respiratória em Tempo Real: Efeito das Alterações no Padrão Ventilatório em Normais.

Author

Magjarevic, R., Nagel, J. H., Müller-Karger, Carmen, Wong, Sara, La Cruz, Alexandra, Dames, K. K., Miranda, I. A., Jansen, J. M., and Melo, P. L.

Abstract

Several respiratory diseases, as well as surgical procedures, introduce pathological alterations in the thoracoabdominal motion. The aim of the present study is to investigate alterations in respiratory mechanics of healthy people, under different breathing patterns by using a real-time implementation of the Forced Oscillation Technique. Twenty individuals were submitted to a protocol in which they performed different breathing patterns for a period of 18 seconds. The results suggest that alterations in the normal breathing pattern can increase the mechanical load of the respiratory system, especially in men and during the exhalation phase. [ABSTRACT FROM AUTHOR]

Published
2008
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50. Validação do uso da técnica de oscilações forçadas no diagnóstico da doença pulmonar obstrutiva crônica.

Author

Magjarevic, R., Nagel, J. H., Müller-Karger, Carmen, Wong, Sara, La Cruz, Alexandra, Fiorot, D., Faria, A. C. D., Nascimento, P. S., Lopes, A. J., Jansen, J. M., and Melo, P. L.

Abstract

The objective of this study was to evaluate the potential of Forced Oscillation Technique (FOT) in the diagnosis of Chronic Obstructive Pulmonary Disease (COPD). A total of 84 individuals were analysed, 28 healthy, 28 mild and moderate COPD and 28 severe COPD. The clinical usefulness of the parameters was evaluated by the analysis of receiver operating characteristic curves, investigating sensibility (Se), specificity (Sp) and the area under the curve (AUC). In the mild and moderate group, 4 of the 7 studied parameters obtained appropriate accuracy for clinical use (AUC>0.8), while in the diagnosis of patients in the severe group, 1 parameter obtained appropriate accuracy and 6 presented high accuracy (AUC>0.9). In conclusion, the parameters obtained by FOT presented adequate Se and Sp, indicating that this technique can be helpful in the evaluation of the respiratory mechanical alterations in patients with COPD. [ABSTRACT FROM AUTHOR]

Published
2008
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