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1. Condensate evolution in the solar nebula inferred from combined Cr, Ti, and O isotope analyses of amoeboid olivine aggregates

Author

Jansen, Christian A., Burkhardt, Christoph, Marrocchi, Yves, Schneider, Jonas M., Wölfer, Elias, and Kleine, Thorsten

Subjects
Astrophysics - Earth and Planetary Astrophysics, Physics - Geophysics
Abstract

Refractory inclusions in chondritic meteorites, namely amoeboid olivine aggregates (AOAs) and Ca-Al-rich inclusions (CAIs), are among the first solids to have formed in the solar system. The isotopic composition of CAIs is distinct from bulk meteorites, which either results from extreme processing of presolar carriers in the CAI-forming region, or reflects an inherited heterogeneity from the Sun's parental molecular cloud. Amoeboid olivine aggregates are less refractory than CAIs and provide a record of how the isotopic composition of solid material in the disk may have changed in time and space. However, the isotopic composition of AOAs and how this composition relates to that of CAIs and later-formed solids is unknown. Here, using new O, Ti, and Cr isotopic data for eight AOAs from the Allende CV3 chondrite, we show that CAIs and AOAs share a common isotopic composition, indicating a close genetic link and formation from the same isotopic reservoir. Because AOAs are less refractory than CAIs, this observation is difficult to reconcile with a thermal processing origin of the isotope anomalies. Instead, the common isotopic composition of CAIs and AOAs is readily accounted for in a model in which the isotopic composition of infalling material from the Sun's parental molecular cloud changed over time. In this model, CAIs and AOAs record the isotopic composition of the early infall, while later-formed solids contain a larger fraction of the later, isotopically distinct infall. This model implies that CAIs and AOAs record the isotopic composition of the Sun and suggests that the nucleosynthetic isotope heterogeneity of the solar system is predominantly produced by mixing of solar nebula condensates, which acquired their distinct isotopic compositions as a result of time-varied infall from the protosolar cloud., Comment: Published gold open access in Earth and Planetary Science Letters

Published
2024
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2. Origin of isotopic diversity among carbonaceous chondrites

Author

Hellmann, Jan L., Schneider, Jonas M., Wölfer, Elias, Drążkowska, Joanna, Jansen, Christian A., Hopp, Timo, Burkhardt, Christoph, and Kleine, Thorsten

Subjects
Astrophysics - Earth and Planetary Astrophysics, Physics - Geophysics
Abstract

Carbonaceous chondrites are some of the most primitive meteorites and derive from planetesimals that formed a few million years after the beginning of the solar system. Here, using new and previously published Cr, Ti, and Te isotopic data, we show that carbonaceous chondrites exhibit correlated isotopic variations that can be accounted for by mixing among three major constituents having distinct isotopic compositions, namely refractory inclusions, chondrules, and CI chondrite-like matrix. The abundances of refractory inclusions and chondrules are coupled and systematically decrease with increasing amount of matrix. We propose that these correlated abundance variations reflect trapping of chondrule precursors, including refractory inclusions, in a pressure maximum in the disk, which is likely related to the water ice line and the ultimate formation location of Jupiter. The variable abundance of refractory inclusions/chondrules relative to matrix is the result of their distinct aerodynamical properties resulting in differential delivery rates and their preferential incorporation into chondrite parent bodies during the streaming instability, consistent with the early formation of matrix-poor and the later accretion of matrix-rich carbonaceous chondrites. Our results suggest that chondrules formed locally from isotopically heterogeneous dust aggregates which themselves derive from a wide area of the disk, implying that dust enrichment in a pressure trap was an important step to facilitate the accretion of carbonaceous chondrite parent bodies or, more generally, planetesimals in the outer solar system., Comment: 12 pages, 4 figures, 1 table. Accepted for publication in ApJL

Published
2023
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4. Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD

Author

Paternostro, Rafael, Kwanten, Wilhelmus J., Hofer, Benedikt Silvester, Semmler, Georg, Bagdadi, Ali, Luzko, Irina, Hernández-Gea, Virginia, Graupera, Isabel, García-Pagán, Juan Carlos, Saltini, Dario, Indulti, Federica, Schepis, Filippo, Moga, Lucile, Rautou, Pierre-Emmanuel, Llop, Elba, Téllez, Luis, Albillos, Agustín, Fortea, Jose Ignacio, Puente, Angela, Tosetti, Giulia, Primignani, Massimo, Zipprich, Alexander, Vuille-Lessard, Elise, Berzigotti, Annalisa, Taru, Madalina-Gabriela, Taru, Vlad, Procopet, Bogdan, Jansen, Christian, Praktiknjo, Michael, Gu, Wenyi, Trebicka, Jonel, Ibanez-Samaniego, Luis, Bañares, Rafael, Rivera-Esteban, Jesús, Pericas, Juan M., Genesca, Joan, Alvarado, Edilmar, Villanueva, Candid, Larrue, Helene, Bureau, Christophe, Laleman, Wim, Ardevol, Alba, Masnou, Helena, Vanwolleghem, Thomas, Trauner, Michael, Mandorfer, Mattias, Francque, Sven, and Reiberger, Thomas

Published
2024
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5. Soluble urokinase plasminogen activator receptor levels predict survival in patients with portal hypertension undergoing TIPS

Author

Loosen, Sven H., Benz, Fabian, Mohr, Raphael, Reuken, Philipp A., Wirtz, Theresa H., Junker, Lioba, Jansen, Christian, Meyer, Carsten, Praktiknjo, Michael, Wree, Alexander, Reißing, Johanna, Demir, Münevver, Gu, Wenyi, Vucur, Mihael, Schierwagen, Robert, Stallmach, Andreas, Kunstein, Anselm, Bode, Johannes, Trautwein, Christian, Tacke, Frank, Luedde, Tom, Bruns, Tony, Trebicka, Jonel, and Roderburg, Christoph

Published
2024
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6. Predicting survival in patients with ‘non-high-risk’ acute variceal bleeding receiving β-blockers+ligation to prevent re-bleeding

Author

Balcar, Lorenz, Mandorfer, Mattias, Hernández-Gea, Virginia, Procopet, Bogdan, Meyer, Elias Laurin, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Samaniego, Luis Ibáñez, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Herrera, Elba Llop, Laleman, Wim, Palazón Azorín, José María, Alonso, Jose Castellote, Gluud, Lise Lotte, Ferreira, Carlos Noronha, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Grønbæk, Henning, Hernandez Guerra, Manuel Nicolas, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan Gonzalez, Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Nevens, Frederik, Calleja, Jose Luis, Jansen, Christian, Catalina, María Vega, Albillos, Agustín, Rudler, Marika, Tapias, Edilmar Alvarado, Guardascione, Maria Anna, Tantau, Marcel, Schwarzer, Rémy, Reiberger, Thomas, Laursen, Stig Borbjerg, Lopez-Gomez, Marta, Cachero, Alba, Ferrarese, Alberto, Ripoll, Cristina, La Mura, Vincenzo, Bosch, Jaime, and García-Pagán, Juan Carlos

Published
2024
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7. How Controlled is the Expansion of VIATORR CX?

Author

Dell, Tatjana, Menne, Matthias, Wagenpfeil, Julia, Praktiknjo, Michael, Jansen, Christian, Isaak, Alexander, Mesropyan, Narine, Steinseifer, Ulrich, Attenberger, Ulrike, Luetkens, Julian, Meyer, Carsten, and Kuetting, Daniel

Published
2023
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10. Aspirin improves transplant-free survival after TIPS implantation in patients with refractory ascites: a retrospective multicentre cohort study

Author

Seifert, Leon Louis, Schindler, Philipp, Sturm, Lukas, Gu, Wenyi, Seifert, Quentin Edward, Weller, Jan Frederic, Jansen, Christian, Praktiknjo, Michael, Meyer, Carsten, Schoster, Martin, Wilms, Christian, Maschmeier, Miriam, Schmidt, Hartmut H., Masthoff, Max, Köhler, Michael, Schultheiss, Michael, Huber, Jan Patrick, Bettinger, Dominik, Trebicka, Jonel, Wildgruber, Moritz, and Heinzow, Hauke

Published
2022
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12. Assessment of Hypercoagulability in Splanchnic Vein Thrombosis by Measurement of the Hemostasis Enzymes Thrombin and Activated Protein C.

Author

Reda, Sara, Chang, Johannes, Busse, Johanna, Schwarz, Nadine, McRae, Hannah L., Müller, Jens, Strassburg, Christian P., Oldenburg, Johannes, Pötzsch, Bernd, Jansen, Christian, and Rühl, Heiko

Subjects
BLOOD coagulation, PROTEIN C, RECEIVER operating characteristic curves, MYELOPROLIFERATIVE neoplasms, PROTHROMBIN, THROMBIN
Abstract

Splanchnic vein thrombosis (SVT), which is particularly prevalent in myeloproliferative neoplasms (MPNs), has a multifactorial pathomechanism involving the anticoagulant protein C (PC) pathway. To better characterize the hypercoagulable state in SVT we assessed its key enzymes thrombin and activated PC (APC). The study population included 73 patients with SVT, thereof 36 MPN+, confirmed by bone marrow biopsy, 37 MPN−, and 30 healthy controls. Direct measurement of the active enzyme forms of thrombin and APC in the circulation was achieved by using oligonucleotide-based enzyme capture assays (OECA). Additionally, activation markers of coagulation and fibrinolysis were measured. Plasma levels of free thrombin and APC were higher in the MPN+ than in the MPN− cohort, with 0.49 vs. <0.46 pmol/L (p = 0.0057), respectively, 1.23 vs. 0.58 pmol/L (p = 0.0122), and in healthy controls (vs. <0.46 pmol/L, p = 0.0012; vs. 0.54 pmol/L, p = 0.0035). The indirect activation markers prothrombin fragment 1+2, thrombin-antithrombin complex, and D-dimer did not differ between groups. Receiver operating characteristic analysis suggested that SVT patients with MPN can be better distinguished by APC than by conventional indirect thrombin markers. A potential application of these biomarkers to guide anticoagulant therapy and to investigate the role of the PC pathway in MPN-associated hypercoagulability should be further studied. [ABSTRACT FROM AUTHOR]

Published
2025
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17. Bacterial infections in patients with acute variceal bleeding in the era of antibiotic prophylaxis

Author

Martínez, Javier, Hernández-Gea, Virginia, Rodríguez-de-Santiago, Enrique, Téllez, Luis, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibañez-Samaniego, Luis, Silva-Junior, Gilberto, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Bañares, Rafael, Krag, Aleksander, Llop, Elba, Laleman, Wim, Palazon, Jose María, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Noronha-Ferreira, Carlos, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Schwarzer, Remy, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Romero-Gomez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Nevens, Frederik, Calleja, Jose Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, Maria Vega, Rudler, Marika, Alvarado, Edilmar, Perez-Campuzano, Valeria, Guardascione, Maria Anna, Fischer, Petra, Bosch, Jaime, García-Pagán, Juan Carlos, and Albillos, Agustín

Published
2021
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20. Refining prediction of survival after TIPS with the novel Freiburg index of post-TIPS survival

Author

Bettinger, Dominik, Sturm, Lukas, Pfaff, Lena, Hahn, Felix, Kloeckner, Roman, Volkwein, Lara, Praktiknjo, Michael, Lv, Yong, Han, Guohong, Huber, Jan Patrick, Boettler, Tobias, Reincke, Marlene, Klinger, Christoph, Caca, Karel, Heinzow, Hauke, Seifert, Leon Louis, Weiss, Karl Heinz, Rupp, Christian, Piecha, Felix, Kluwe, Johannes, Zipprich, Alexander, Luxenburger, Hendrik, Neumann-Haefelin, Christoph, Schmidt, Arthur, Jansen, Christian, Meyer, Carsten, Uschner, Frank E., Brol, Maximilian J., Trebicka, Jonel, Rössle, Martin, Thimme, Robert, and Schultheiss, Michael

Published
2021
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21. PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Author

Maschmeier, Miriam, Semela, David, Elkrief, Laure, Elsharkawy, Ahmed, Tornai, Tamas, Tornai, Istvan, Altorjay, Istvan, Antognoli, Agnese, Baldassarre, Maurizio, Gagliardi, Martina, Bertoli, Eleonora, Mareso, Sara, Brocca, Alessandra, Campion, Daniela, Saracco, Giorgio Maria, Rizzo, Martina, Lehmann, Jennifer, Pohlmann, Alessandra, Brol, Maximilian J., Chang, Johannes, Schierwagen, Robert, Solà, Elsa, Amari, Nesrine, Rodriguez, Miguel, Nevens, Frederik, Clemente, Ana, Janicko, Martin, Markwardt, Daniel, Mandorfer, Mattias, Welsch, Christoph, Welzel, Tanja M., Ciraci, Emanuela, Patel, Vish, Ripoll, Cristina, Herber, Adam, Horn, Paul, Bendtsen, Flemming, Gluud, Lise Lotte, Schaapman, Jelte, Riggio, Oliviero, Rainer, Florian, Moritz, Jörg Tobiasch, Mesquita, Mónica, Alvarado-Tapias, Edilmar, Akpata, Osagie, Aamann, Luise, Samuel, Didier, Tresson, Sylvie, Strnad, Pavel, Amathieu, Roland, Simón-Talero, Macarena, Smits, Francois, van den Ende, Natalie, Martinez, Javier, Garcia, Rita, Rupprechter, Harald, Engelmann, Cornelius, Özdogan, Osman Cavit, Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jansen, Christian, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Jarcuska, Peter, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Shawcross, Debbie L., Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Danielsen, Karen Vagner, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solé, Cristina, Soriano, Germán, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Kani, Haluk Tarik, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia-Lopez, Elisabet, Tufoni, Manuel, Amoros, Alex, Pavesi, Marco, Sanchez, Cristina, Praktiknjo, Michael, Curto, Anna, Pitarch, Carla, Putignano, Antonella, Moreno, Esau, Bernal, William, Aguilar, Ferran, Clària, Joan, Ponzo, Paola, Vitalis, Zsuzsanna, Zaccherini, Giacomo, Balogh, Boglarka, Gerbes, Alexander, Vargas, Victor, Alessandria, Carlo, Bernardi, Mauro, Ginès, Pere, Moreau, Richard, Angeli, Paolo, Jalan, Rajiv, and Arroyo, Vicente

Published
2021
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23. Balance between macrophage migration inhibitory factor and sCD74 predicts outcome in patients with acute decompensation of cirrhosis

Author

Wirtz, Theresa H., Reuken, Philipp A., Jansen, Christian, Fischer, Petra, Bergmann, Irina, Backhaus, Christina, Emontzpohl, Christoph, Reißing, Johanna, Brandt, Elisa F., Koenen, M. Teresa, Schneider, Kai M., Schierwagen, Robert, Brol, Maximilian J., Chang, Johannes, Zimmermann, Henning W., Köse-Vogel, Nilay, Eggermann, Thomas, Kurth, Ingo, Stoppe, Christian, Bucala, Richard, Bernhagen, Jürgen, Praktiknjo, Michael, Stallmach, Andreas, Trautwein, Christian, Trebicka, Jonel, Bruns, Tony, and Berres, Marie-Luise

Published
2021
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24. Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data

Author

Bureau, Christophe, Abraldes, Juan G., Nevens, Frederik, Caca, Karel, Laleman, Wim, Appenrodt, Beate, Luca, Angelo, Vinel, Jean Pierre, Mössner, Joachim, Di Pascoli, Marco, Zipprich, Alexander, Sauerbruch, Tilman, Martinez-Lagares, Francisco, Ruiz-del-Arbol, Luis, Sierra, Angel, Guevara, Clemencia, Jimenez, Elena, Marrero, Jose Miguel, Buceta, Enrique, Sanchez, Juan, Castellot, Ana, Penate, Monica, Cruz, Ana, Pena, Elena, Procopeț, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Ibañez-Samaniego, Luis, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Trebicka, Jonel, Llop, Elba, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell’Era, Alessandra, Senzolo, Marco, Romero-Gómez, Manuel, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Calleja, Jose Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, Maria-Vega, Albillos, Agustin, Alvarado, Edilmar, Guardascione, Maria Anna, Tanțău, Marcel, Zuo, Luo, Zhu, Xuan, Zhao, Jianbo, Xue, Hui, Jiang, Zaibo, Zhuge, Yuzheng, Zhang, Chunqing, Sun, Junhui, Ding, Pengxu, Ren, Weixin, Li, Yingchun, Zhang, Kewei, Zhang, Wenguang, He, Chuangye, Zhong, Jiawei, Peng, Qifeng, Ma, Fuquan, Luo, Junyang, Zhang, Ming, Wang, Guangchuan, Sun, Minhuang, Dong, Junjiao, Bai, Wei, Guo, Wengang, Wang, Qiuhe, Yuan, Xulong, Wang, Zhengyu, Yu, Tianlei, Luo, Bohan, Li, Xiaomei, Yuan, Jie, Han, Na, Zhu, Ying, Niu, Jing, Li, Kai, Yin, Zhanxin, Nie, Yongzhan, Fischer, Petra, Horia Ștefănescu, Pop, Andreea, Laursen, Stig B., Turon, Fanny, Baiges, Anna, Ferrusquía-Acosta, José, Magaz, Marta, Cerda, Eira, Tellez, Luis, Allegretti, Giulia, Macedo, Guilherme, Haldrup, David, Santos, Patricia, Moura, Miguel, Reis, Daniela, Meireles, Liliane, Sousa, Patricia, Alexandrino, Paula, Navascues, Carmen, Augustin, Salvador, La Mura, Vincenzo, Bañares, Rafael, Diaz, Raquel, Gómez, Marta López, Ripoll, Cristina, Nicoară-Farcău, Oana, Han, Guohong, Rudler, Marika, Angrisani, Debora, Monescillo, Alberto, Torres, Ferran, Casanovas, Georgina, Bosch, Jaime, Lv, Yong, Thabut, Dominique, Fan, Daiming, Hernández-Gea, Virginia, and García-Pagán, Juan Carlos

Published
2021
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28. Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Author

Trebicka, Jonel, Gu, Wenyi, Ibáñez-Samaniego, Luis, Hernández-Gea, Virginia, Pitarch, Carla, Garcia, Elisabet, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Cristophe, Llop, Elba, Laleman, Wim, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susanag, Gluud, Liselotte, Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Weiss, Emmanuel, Catalina, Maria-Vega, Erasmus, Hans-Peter, Uschner, Frank Erhard, Schulz, Martin, Brol, Maximilian J., Praktiknjo, Michael, Chang, Johannes, Krag, Aleksander, Nevens, Frederik, Calleja, Jose Luis, Robic, Marie Angèle, Conejo, Irene, Albillos, Agustin, Rudler, Marika, Alvarado, Edilmar, Guardascione, Maria Anna, Tantau, Marcel, Bosch, Jaime, Torres, Ferran, Pavesi, Marco, Garcia-Pagán, Juan Carlos, Jansen, Christian, and Bañares, Rafael

Published
2020
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29. The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

Author

Maschmeier, Miriam, Semela, David, Elkrief, Laure, Elsharkawy, Ahmed, Tornai, Tamas, Tornai, Istvan, Altorjay, Istvan, Antognoli, Agnese, Baldassarre, Maurizio, Gagliardi, Martina, Bertoli, Eleonora, Mareso, Sara, Brocca, Alessandra, Campion, Daniela, Saracco, Giorgio Maria, Rizzo, Martina, Lehmann, Jennifer, Pohlmann, Alessandra, Praktiknjo, Michael, Schierwagen, Robert, Solà, Elsa, Amari, Nesrine, Rodriguez, Miguel, Nevens, Frederik, Clemente, Ana, Jarcuska, Peter, Gerbes, Alexander, Mandorfer, Mattias, Welsch, Christoph, Ciraci, Emanuela, Patel, Vish, Ripoll, Cristina, Herber, Adam, Horn, Paul, Danielsen, Karen Vagner, Gluud, Lise Lotte, Schaapman, Jelte, Riggio, Oliviero, Rainer, Florian, Moritz, Jörg Tobiasch, Mesquita, Mónica, Alvarado-Tapias, Edilmar, Akpata, Osagie, Lykke Eriksen, Peter, Samuel, Didier, Tresson, Sylvie, Strnad, Pavel, Amathieu, Roland, Simón-Talero, Macarena, Smits, Francois, van den Ende, Natalie, Martinez, Javier, Garcia, Rita, Markwardt, Daniel, Rupprechter, Harald, Engelmann, Cornelius, Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Janicko, Martin, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Bernal, William, Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Bendtsen, Flemming, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solè, Cristina, Soriano, Germán, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Özdogan, Osman Cavit, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia, Elisabet, Tufoni, Manuel, Amoros, Alex, Pavesi, Marco, Sanchez, Cristina, Curto, Anna, Pitarch, Carla, Putignano, Antonella, Moreno, Esau, Shawcross, Debbie, Aguilar, Ferran, Clària, Joan, Ponzo, Paola, Jansen, Christian, Vitalis, Zsuzsanna, Zaccherini, Giacomo, Balogh, Boglarka, Vargas, Victor, Montagnese, Sara, Alessandria, Carlo, Bernardi, Mauro, Ginès, Pere, Jalan, Rajiv, Moreau, Richard, Angeli, Paolo, and Arroyo, Vicente

Published
2020
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30. Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis

Author

Quiroga, Sergi, Yu, Dominic, Téllez, Luis, Mandorfer, Mattias, Garcia-Pagan, Juan Carlos, Berbel, Claudia, Ferrusquia, José, Ble, Michel, Garcia-Criado, Mari Angeles, Belmonte, Ernest, Ney, Michael, Margini, Cristina, Casu, Stefania, Murgia, Giuseppe, Ludwig, Christiane, Stangl, Franz, Praktiknjo, Michael, Simón-Talero, Macarena, Römer, Julia, Roccarina, Davide, Martínez, Javier, Lampichler, Katharina, Baiges, Anna, Low, Gavin, Llop, Elba, Maurer, Martin H., Zipprich, Alexander, Triolo, Michela, Maleux, Geert, Fialla, Annette Dam, Dam, Claus, Vidal-González, Judit, Majumdar, Avik, Picón, Carmen, Toth, Daniel, Darnell, Anna, Abraldes, Juan G., López, Marta, Jansen, Christian, Chang, Johannes, Schierwagen, Robert, Uschner, Frank, Kukuk, Guido, Meyer, Carsten, Thomas, Daniel, Wolter, Karsten, Strassburg, Christian P., Laleman, Wim, La Mura, Vincenzo, Ripoll, Cristina, Berzigotti, Annalisa, Calleja, José Luis, Tandon, Puneeta, Hernandez-Gea, Virginia, Reiberger, Thomas, Albillos, Agustín, Tsochatzis, Emmanuel A., Krag, Aleksander, Genescà, Joan, and Trebicka, Jonel

Published
2020
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31. Efficacy of Albumin Treatment for Patients with Cirrhosis and Infections Unrelated to Spontaneous Bacterial Peritonitis

Author

Fernández, Javier, Angeli, Paolo, Trebicka, Jonel, Merli, Manuela, Gustot, Thierry, Alessandria, Carlo, Aagaard, Niels Kristian, de Gottardi, Andrea, Welzel, Tania M., Gerbes, Alexander, Soriano, German, Vargas, Victor, Albillos, Agustin, Salerno, Francesco, Durand, Francois, Bañares, Rafael, Stauber, Rudolf, Prado, Verónica, Arteaga, Mireya, Hernández-Tejero, María, Aziz, Fátima, Morando, Filippo, Jansen, Christian, Lattanzi, Barbara, Moreno, Christophe, Campion, Daniela, Gronbaek, Henning, Garcia, Rita, Sánchez, Cristina, García, Elisabet, Amorós, Alex, Pavesi, Marco, Clària, Joan, Moreau, Richard, and Arroyo, Vicente

Published
2020
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32. Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF

Author

Moreau, Richard, Clària, Joan, Aguilar, Ferran, Fenaille, François, Lozano, Juan José, Junot, Christophe, Colsch, Benoit, Caraceni, Paolo, Trebicka, Jonel, Pavesi, Marco, Alessandria, Carlo, Nevens, Frederik, Saliba, Faouzi, Welzel, Tania M., Albillos, Agustin, Gustot, Thierry, Fernández, Javier, Moreno, Christophe, Baldassarre, Maurizio, Zaccherini, Giacomo, Piano, Salvatore, Montagnese, Sara, Vargas, Victor, Genescà, Joan, Solà, Elsa, Bernal, William, Butin, Noémie, Hautbergue, Thaïs, Cholet, Sophie, Castelli, Florence, Jansen, Christian, Steib, Christian, Campion, Daniela, Mookerjee, Raj, Rodríguez-Gandía, Miguel, Soriano, German, Durand, François, Benten, Daniel, Bañares, Rafael, Stauber, Rudolf E., Gronbaek, Henning, Coenraad, Minneke J., Ginès, Pere, Gerbes, Alexander, Jalan, Rajiv, Bernardi, Mauro, Arroyo, Vicente, and Angeli, Paolo

Published
2020
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Author

Balcar, Lorenz, Mandorfer, Mattias, Hernández-Gea, Virginia, Procopet, Bogdan, Meyer, Elias Laurin, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Samaniego, Luis Ibáñez, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Herrera, Elba Llop, Laleman, Wim, Palazón Azorín, José María, Alonso, Jose Castellote, Gluud, Lise Lotte, Ferreira, Carlos Noronha, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Grønbæk, Henning, Hernandez Guerra, Manuel Nicolas, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan Gonzalez, Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Nevens, Frederik, Calleja, Jose Luis, Jansen, Christian, Catalina, María Vega, Albillos, Agustín, Rudler, Marika, Tapias, Edilmar Alvarado, Guardascione, Maria Anna, Tantau, Marcel, Schwarzer, Rémy, Reiberger, Thomas, Laursen, Stig Borbjerg, Lopez-Gomez, Marta, Balcar, Lorenz, Mandorfer, Mattias, Hernández-Gea, Virginia, Procopet, Bogdan, Meyer, Elias Laurin, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Samaniego, Luis Ibáñez, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Herrera, Elba Llop, Laleman, Wim, Palazón Azorín, José María, Alonso, Jose Castellote, Gluud, Lise Lotte, Ferreira, Carlos Noronha, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Grønbæk, Henning, Hernandez Guerra, Manuel Nicolas, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan Gonzalez, Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Nevens, Frederik, Calleja, Jose Luis, Jansen, Christian, Catalina, María Vega, Albillos, Agustín, Rudler, Marika, Tapias, Edilmar Alvarado, Guardascione, Maria Anna, Tantau, Marcel, Schwarzer, Rémy, Reiberger, Thomas, Laursen, Stig Borbjerg, and Lopez-Gomez, Marta

Abstract

Background & Aims Pre-emptive transjugular intrahepatic portosystemic shunt (TIPS) is the treatment of choice for high-risk acute variceal bleeding (AVB; i.e., Child-Turcotte-Pugh [CTP] B8-9+active bleeding/C10-13). Nevertheless, some ‘non-high-risk’ patients have poor outcomes despite the combination of non-selective beta-blockers and endoscopic variceal ligation for secondary prophylaxis. We investigated prognostic factors for re-bleeding and mortality in ‘non-high-risk’ AVB to identify subgroups who may benefit from more potent treatments (i.e., TIPS) to prevent further decompensation and mortality. Methods A total of 2,225 adults with cirrhosis and variceal bleeding were prospectively recruited at 34 centres between 2011-2015; for the purpose of this study, case definitions and information on prognostic indicators at index AVB and on day 5 were further refined in low-risk patients, of whom 581 (without failure to control bleeding or contraindications to TIPS) who were managed by non-selective beta-blockers/endoscopic variceal ligation, were finally included. Patients were followed for 1 year. Results Overall, 90 patients (15%) re-bled and 70 (12%) patients died during follow-up. Using clinical routine data, no meaningful predictors of re-bleeding were identified. However, re-bleeding (included as a time-dependent co-variable) increased mortality, even after accounting for differences in patient characteristics (adjusted cause-specific hazard ratio: 2.57; 95% CI 1.43-4.62; p = 0.002). A nomogram including CTP, creatinine, and sodium measured at baseline accurately (concordance: 0.752) stratified the risk of death. Conclusion The majority of ‘non-high-risk’ patients with AVB have an excellent prognosis, if treated according to current recommendations. However, about one-fifth of patients, i.e. those with CTP ≥8 and/or high creatinine levels or hyponatremia, have a considerable risk of death within 1 year of the index, Background & Aims: Pre-emptive transjugular intrahepatic portosystemic shunt (TIPS) is the treatment of choice for high-risk acute variceal bleeding (AVB; i.e., Child-Turcotte-Pugh [CTP] B8-9+active bleeding/C10-13). Nevertheless, some ‘non-high-risk’ patients have poor outcomes despite the combination of non-selective beta-blockers and endoscopic variceal ligation for secondary prophylaxis. We investigated prognostic factors for re-bleeding and mortality in ‘non-high-risk’ AVB to identify subgroups who may benefit from more potent treatments (i.e., TIPS) to prevent further decompensation and mortality. Methods: A total of 2,225 adults with cirrhosis and variceal bleeding were prospectively recruited at 34 centres between 2011-2015; for the purpose of this study, case definitions and information on prognostic indicators at index AVB and on day 5 were further refined in low-risk patients, of whom 581 (without failure to control bleeding or contraindications to TIPS) who were managed by non-selective beta-blockers/endoscopic variceal ligation, were finally included. Patients were followed for 1 year. Results: Overall, 90 patients (15%) re-bled and 70 (12%) patients died during follow-up. Using clinical routine data, no meaningful predictors of re-bleeding were identified. However, re-bleeding (included as a time-dependent co-variable) increased mortality, even after accounting for differences in patient characteristics (adjusted cause-specific hazard ratio: 2.57; 95% CI 1.43-4.62; p = 0.002). A nomogram including CTP, creatinine, and sodium measured at baseline accurately (concordance: 0.752) stratified the risk of death. Conclusion: The majority of ‘non-high-risk’ patients with AVB have an excellent prognosis, if treated according to current recommendations. However, about one-fifth of patients, i.e. those with CTP ≥8 and/or high creatinine levels or hyponatremia, have a considerable risk of death within 1 year of the index bleed. Future clinical trials should

Published
2024

43. Predicting survival in patients with ‘non-high-risk’ acute variceal bleeding receiving β-blockers+ligation to prevent re-bleeding

Author

Balcar, Lorenz, primary, Mandorfer, Mattias, additional, Hernández-Gea, Virginia, additional, Procopet, Bogdan, additional, Meyer, Elias Laurin, additional, Giráldez, Álvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Thabut, Dominique, additional, Samaniego, Luis Ibáñez, additional, Silva-Junior, Gilberto, additional, Martinez, Javier, additional, Genescà, Joan, additional, Bureau, Christophe, additional, Trebicka, Jonel, additional, Llop Herrera, Elba, additional, Laleman, Wim, additional, Palazón Azorín, José María, additional, Castellote Alonso, Jose, additional, Gluud, Lise Lotte, additional, Noronha Ferreira, Carlos, additional, Cañete, Nuria, additional, Rodríguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose Luis, additional, Grønbæk, Henning, additional, Hernandez Guerra, Manuel Nicolas, additional, Sassatelli, Romano, additional, Dell'Era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan Gonzalez, additional, Romero-Gómez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Krag, Aleksander, additional, Nevens, Frederik, additional, Calleja, Jose Luis, additional, Jansen, Christian, additional, Vega Catalina, María, additional, Albillos, Agustín, additional, Rudler, Marika, additional, Tapias, Edilmar Alvarado, additional, Guardascione, Maria Anna, additional, Tantau, Marcel, additional, Schwarzer, Rémy, additional, Reiberger, Thomas, additional, Laursen, Stig Borbjerg, additional, Lopez-Gomez, Marta, additional, Cachero, Alba, additional, Ferrarese, Alberto, additional, Ripoll, Cristina, additional, La Mura, Vincenzo, additional, Bosch, Jaime, additional, and García-Pagán, Juan Carlos, additional

Published
2023
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45. Advancing microbiome research with machine learning: key findings from the ML4Microbiome COST action

Author

D’Elia, Domenica, primary, Truu, Jaak, additional, Lahti, Leo, additional, Berland, Magali, additional, Papoutsoglou, Georgios, additional, Ceci, Michelangelo, additional, Zomer, Aldert, additional, Lopes, Marta B., additional, Ibrahimi, Eliana, additional, Gruca, Aleksandra, additional, Nechyporenko, Alina, additional, Frohme, Marcus, additional, Klammsteiner, Thomas, additional, Pau, Enrique Carrillo-de Santa, additional, Marcos-Zambrano, Laura Judith, additional, Hron, Karel, additional, Pio, Gianvito, additional, Simeon, Andrea, additional, Suharoschi, Ramona, additional, Moreno-Indias, Isabel, additional, Temko, Andriy, additional, Nedyalkova, Miroslava, additional, Apostol, Elena-Simona, additional, Truică, Ciprian-Octavian, additional, Shigdel, Rajesh, additional, Telalović, Jasminka Hasić, additional, Bongcam-Rudloff, Erik, additional, Przymus, Piotr, additional, Jordamović, Naida Babić, additional, Falquet, Laurent, additional, Tarazona, Sonia, additional, Sampri, Alexia, additional, Isola, Gaetano, additional, Pérez-Serrano, David, additional, Trajkovik, Vladimir, additional, Klucar, Lubos, additional, Loncar-Turukalo, Tatjana, additional, Havulinna, Aki S., additional, Jansen, Christian, additional, Bertelsen, Randi J., additional, and Claesson, Marcus Joakim, additional

Published
2023
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