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18 results on '"Janse van Mantgem, Mark R"'

1. Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial

Author

Granit, Volkan, Steele, Julie, Levy, Wendy, Paredes, Maria Elena, Hernandez, Jessica, Bilsker, Martin, Szacka, Katarzyna, Ronert, Adam, Jablońska, Dorota, Łuczak, Alina Zuzanna, Chaverri, Delia, Janse van Mantgem, Mark R, Bunte, Tommy M, Broere, Bianca, de Fockert, Arianne, Sanchez-Tejerina, Daniel, Landabaso, Carmen, Calvo, Andrea, Moglia, Cristina, Manera, Umberto, Canosa, Antonio, Vasta, Rosario, Salamone, Paolina, Fuda, Giuseppe, DeMarco, Giovanni, Casale, Federico, ME Forsberg, Karin, Winroth, Ivar, Almgren Stenberg, Erica, Holmgren, Monica, Amador, Maria del Mar, Lenglet, Timothee, Querin, Giorgia, Coudoin, Sylvie, Pavlakis, Pantelis, Holzberg, Shara, Sideri, Riccardo, Marinou, Kalliopi, Czarnecki, Maciej, Ługiewicz, Renata, Biel-Czarnecka, Marta, Boczkowska, Marcelina, Schotte, Caroline, Vynckier, Jan, Van Daele, Sien, Claeys, Thomas, Delmotte, Koen, Swinnen, Bart, Serrien, Anouk, D'Hondt, Ann, Lamaire, Nikita, Debien, Elisa, Jones, Sarah, Vachon, Chris, Grogan, James, Solorzano, Guillermo, Crowell, Allison, Rakocevic, Goran, Wagoner, Mary, Alma, Osmanovic, Flavia, Wiehler, Sonja, Körner, Olivia, Schreiber-Katz, Camilla, Wohnrade, Anastasia, Sarikidi, Carola, Kassebaum, Chantal, Fischer, Adamo, Ashley, Turcotte, Nicole, Duncan, Jessie, Turner, Ivone, Elman, Lauren, Massie, Rami, Berube, Maxime, Saunders, Natalie, Salmon, Kristiana, Foucher, Juliette, Agessandro, Abrahao, Shirley, Pham, Jahan, Mookshah, Phung, Liane, Statland, Jeffrey, Jawdat, Omar, Dimachkie, Mazen, Pasnoor, Mamatha, Farmakidis, Constantine, Heim, Andrew, Lillig, Katie, Lackey, Alyssa, Weber, Markus, Kurz, Martina, Levine, Todd, Benatar, Michael, Hansen, Thomas, Rom, Dror, Geist, Marie A, Blaettler, Thomas, Camu, William, Kuzma-Kozakiewicz, Magdalena, van den Berg, Leonard H, Morales, Raul Juntas, Chio, Adriano, Andersen, Peter M, Pradat, Pierre-Francois, Lange, Dale, Van Damme, Philip, Mora, Gabriele, Grudniak, Mariusz, Elliott, Matthew, Petri, Susanne, Olney, Nicholas, Ladha, Shafeeq, Goyal, Namita A, Meyer, Thomas, Hanna, Michael G, Quinn, Colin, Genge, Angela, Zinman, Lorne, Jabari, Duaa, Shoesmith, Christen, Ludolph, Albert C, Neuwirth, Christoph, Nations, Sharon, Shefner, Jeremy M, Turner, Martin R, Wuu, Joanne, Bennett, Richard, Dang, Hoang, and Sundgreen, Claus

Published
2024
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3. A comparison between bioelectrical impedance analysis and air-displacement plethysmography in assessing fat-free mass in patients with motor neurone diseases: a cross-sectional study

Author

Opleiding Neurologie, ALS Onderzoeksbureau, Projectafdeling ALS, Neurologen, Brain, Afdeling Dietetiek, Cancer, Datamanagement Team 1, Janse van Mantgem, Mark R., Soors D’Ancona, Maaike L., Meyjes, Myrte, Van Den Berg, Leonard H., Steenhagen, Elles, Kok, Annemieke, Van Eijk, Ruben P.A., Opleiding Neurologie, ALS Onderzoeksbureau, Projectafdeling ALS, Neurologen, Brain, Afdeling Dietetiek, Cancer, Datamanagement Team 1, Janse van Mantgem, Mark R., Soors D’Ancona, Maaike L., Meyjes, Myrte, Van Den Berg, Leonard H., Steenhagen, Elles, Kok, Annemieke, and Van Eijk, Ruben P.A.

Published
2024

4. Association Between Hypothalamic Volume and Metabolism, Cognition, and Behavior in Patients With Amyotrophic Lateral Sclerosis

Author

Opleiding Neurologie, Neurologen, Brain, Neuromuscular Disorders, Genetic Risks, Projectafdeling ALS, Regenerative Medicine and Stem Cells, Michielsen, Annebelle, van Veenhuijzen, Kevin, Janse van Mantgem, Mark R., van Es, Michael A., Veldink, Jan H., van Eijk, Ruben P.A., van den Berg, Leonard H., Westeneng, Henk Jan, Opleiding Neurologie, Neurologen, Brain, Neuromuscular Disorders, Genetic Risks, Projectafdeling ALS, Regenerative Medicine and Stem Cells, Michielsen, Annebelle, van Veenhuijzen, Kevin, Janse van Mantgem, Mark R., van Es, Michael A., Veldink, Jan H., van Eijk, Ruben P.A., van den Berg, Leonard H., and Westeneng, Henk Jan

Published
2024

5. Remote monitoring of amyotrophic lateral sclerosis using wearable sensors detects differences in disease progression and survival: a prospective cohort study

Author

Projectafdeling ALS, ALS Onderzoeksbureau, Opleiding Neurologie, Neurologen, Brain, Datamanagement Team 1, van Unnik, Jordi W.J., Meyjes, Myrte, Janse van Mantgem, Mark R., van den Berg, Leonard H., van Eijk, Ruben P.A., Projectafdeling ALS, ALS Onderzoeksbureau, Opleiding Neurologie, Neurologen, Brain, Datamanagement Team 1, van Unnik, Jordi W.J., Meyjes, Myrte, Janse van Mantgem, Mark R., van den Berg, Leonard H., and van Eijk, Ruben P.A.

Published
2024

6. Variation in Resting Metabolic Rate Affects Identification of Metabolic Change in Geographically Distinct Cohorts of Patients With ALS

Author

Holdom, Cory J., primary, Janse van Mantgem, Mark R., additional, He, Ji, additional, Howe, Stephanie L., additional, McCombe, Pamela A., additional, Fan, Dongsheng, additional, van den Berg, Leonard H., additional, Henderson, Robert D., additional, van Eijk, Ruben, additional, Steyn, Frederik J., additional, and Ngo, Shyuan T., additional

Published
2024
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8. Association Between Serum Lipids and Survival in Patients With Amyotrophic Lateral Sclerosis: A Meta-analysis and Population-Based Study

Author

Opleiding Neurologie, Neurologen, Brain, Neuromuscular Disorders, Genetic Risks, Projectafdeling ALS, Regenerative Medicine and Stem Cells, Datamanagement Team 1, Janse Van Mantgem, Mark R., Van Rheenen, Wouter, Hackeng, Anemone V., Van Es, Michael A., Veldink, Jan H., Van Den Berg, Leonard H., Van Eijk, Ruben P.A., Opleiding Neurologie, Neurologen, Brain, Neuromuscular Disorders, Genetic Risks, Projectafdeling ALS, Regenerative Medicine and Stem Cells, Datamanagement Team 1, Janse Van Mantgem, Mark R., Van Rheenen, Wouter, Hackeng, Anemone V., Van Es, Michael A., Veldink, Jan H., Van Den Berg, Leonard H., and Van Eijk, Ruben P.A.

Published
2023

11. Distinctive pattern of temporal atrophy in patients with frontotemporal dementia and the I383V variant in TARDBP

Author

Mol, Merel O., Nijmeijer, Sebastiaan W.R., Van Rooij, Jeroen G.J., Van Spaendonk, Resie M.L., Pijnenburg, Yolande A.L., Van Der Lee, Sven J., Van Minkelen, Rick, Donker Kaat, Laura, Rozemuller, Annemieke J.M., Janse Van Mantgem, Mark R., Van Rheenen, Wouter, Van Es, Michael A., Veldink, Jan H., Hennekam, Frederic A.M., Vernooij, Meike, Van Swieten, John C., Cohn-Hokke, Petra E., Seelaar, Harro, Dopper, Elise G.P., Mol, Merel O., Nijmeijer, Sebastiaan W.R., Van Rooij, Jeroen G.J., Van Spaendonk, Resie M.L., Pijnenburg, Yolande A.L., Van Der Lee, Sven J., Van Minkelen, Rick, Donker Kaat, Laura, Rozemuller, Annemieke J.M., Janse Van Mantgem, Mark R., Van Rheenen, Wouter, Van Es, Michael A., Veldink, Jan H., Hennekam, Frederic A.M., Vernooij, Meike, Van Swieten, John C., Cohn-Hokke, Petra E., Seelaar, Harro, and Dopper, Elise G.P.

Published
2021

12. Venous creatinine as a biomarker for loss of fat-free mass and disease progression in patients with Amyotrophic Lateral Sclerosis

Author

Projectafdeling ALS, Brain, Neurologen, Regenerative Medicine and Stem Cells, Holdom, Cory J, Janse van Mantgem, Mark R, van Eijk, Ruben P A, Howe, Stephanie L, van den Berg, Leonard H, McCombe, Pamela A, Henderson, Robert D, Ngo, Shyuan T, Steyn, Frederik J, Projectafdeling ALS, Brain, Neurologen, Regenerative Medicine and Stem Cells, Holdom, Cory J, Janse van Mantgem, Mark R, van Eijk, Ruben P A, Howe, Stephanie L, van den Berg, Leonard H, McCombe, Pamela A, Henderson, Robert D, Ngo, Shyuan T, and Steyn, Frederik J

Published
2021

13. Distinctive pattern of temporal atrophy in patients with frontotemporal dementia and the I383V variant in TARDBP

Author

Pathologie, Projectafdeling ALS, Projectafdeling SvS, Neurologen, Brain, Genetica Klinische Genetica, Mol, Merel O, Nijmeijer, Sebastiaan W R, van Rooij, Jeroen G J, van Spaendonk, Resie M L, Pijnenburg, Yolande A L, van der Lee, Sven J, van Minkelen, Rick, Donker Kaat, Laura, Rozemuller, Annemieke J M, Janse van Mantgem, Mark R, van Rheenen, Wouter, van Es, Michael A, Veldink, Jan H, Hennekam, Frederic A M, Vernooij, Meike, van Swieten, John C, Cohn-Hokke, Petra E, Seelaar, Harro, Dopper, Elise G P, Pathologie, Projectafdeling ALS, Projectafdeling SvS, Neurologen, Brain, Genetica Klinische Genetica, Mol, Merel O, Nijmeijer, Sebastiaan W R, van Rooij, Jeroen G J, van Spaendonk, Resie M L, Pijnenburg, Yolande A L, van der Lee, Sven J, van Minkelen, Rick, Donker Kaat, Laura, Rozemuller, Annemieke J M, Janse van Mantgem, Mark R, van Rheenen, Wouter, van Es, Michael A, Veldink, Jan H, Hennekam, Frederic A M, Vernooij, Meike, van Swieten, John C, Cohn-Hokke, Petra E, Seelaar, Harro, and Dopper, Elise G P

Published
2021

14. Prognostic value of weight loss in patients with amyotrophic lateral sclerosis: a population-based study

Author

Projectafdeling ALS, Datamanagement Team, Brain, Opleiding Neurologie, ZL Neuromusculaire Ziekten Medisch, Neurogenetica, Regenerative Medicine and Stem Cells, Janse van Mantgem, Mark R, van Eijk, Ruben P A, van der Burgh, Hannelore K, Tan, Harold H G, Westeneng, Henk-Jan, van Es, Michael A, Veldink, Jan H, van den Berg, Leonard H, Projectafdeling ALS, Datamanagement Team, Brain, Opleiding Neurologie, ZL Neuromusculaire Ziekten Medisch, Neurogenetica, Regenerative Medicine and Stem Cells, Janse van Mantgem, Mark R, van Eijk, Ruben P A, van der Burgh, Hannelore K, Tan, Harold H G, Westeneng, Henk-Jan, van Es, Michael A, Veldink, Jan H, and van den Berg, Leonard H

Published
2020

15. Distinctive pattern of temporal atrophy in patients with frontotemporal dementia and the I383V variant in TARDBP

Author

Mol, Merel O., primary, Nijmeijer, Sebastiaan W.R., additional, van Rooij, Jeroen G. J., additional, van Spaendonk, Resie M. L., additional, Pijnenburg, Yolande A. L., additional, van der Lee, Sven J., additional, van Minkelen, Rick, additional, Donker Kaat, Laura, additional, Rozemuller, Annemieke J. M., additional, Janse van Mantgem, Mark R., additional, van Rheenen, Wouter, additional, van Es, Michael A., additional, Veldink, Jan H., additional, Hennekam, Frederic A. M., additional, Vernooij, Meike, additional, van Swieten, John C., additional, Cohn-Hokke, Petra E., additional, Seelaar, Harro, additional, and Dopper, Elise G.P., additional

Published
2021
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17. Prognostic value of weight loss in patients with amyotrophic lateral sclerosis: a population-based study.

Author

van Mantgem, Mark R. Janse, van Eijk, Ruben P. A., van der Burgh, Hannelore K., Tan, Harold H. G., Westeneng, Henk-Jan, van Es, Michael A., Veldink, Jan H., van den Berg, Leonard H., and Janse van Mantgem, Mark R

Subjects
AMYOTROPHIC lateral sclerosis, MEDICAL ethics, SMELL disorders, BODY weight, COMPARATIVE studies, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, PROGNOSIS, RESEARCH, WEIGHT loss, EVALUATION research, DISEASE prevalence, DISEASE progression
Abstract

Objective: To determine the prevalence and prognostic value of weight loss (WL) prior to diagnosis in patients with amyotrophic lateral sclerosis (ALS).Methods: We enrolled patients diagnosed with ALS between 2010 and 2018 in a population-based setting. At diagnosis, detailed information was obtained regarding the patient's disease characteristics, anthropological changes, ALS-related genotypes and cognitive functioning. Complete survival data were obtained. Cox proportional hazard models were used to assess the association between WL and the risk of death during follow-up.Results: The data set comprised 2420 patients of whom 67.5% reported WL at diagnosis. WL occurred in 71.8% of the bulbar-onset and in 64.2% of the spinal-onset patients; the mean loss of body weight was 6.9% (95% CI 6.8 to 6.9) and 5.5% (95% CI 5.5 to 5.6), respectively (p<0.001). WL occurred in 35.1% of the patients without any symptom of dysphagia. WL is a strong independent predictor of survival, with a dose response relationship between the amount of WL and the risk of death: the risk of death during follow-up increased by 23% for every 10% increase in WL relative to body weight (HR 1.23, 95% CI 1.13 to 1.51, p<0.001).Conclusions: This population-based study shows that two-thirds of the patients with ALS have WL at diagnosis, which also occurs independent of dysphagia, and is related to survival. Our results suggest that WL is a multifactorial process that may differ from patient to patient. Gaining further insight in its underlying factors could prove essential for future therapeutic measures. [ABSTRACT FROM AUTHOR]

Published
2020
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18. Association Between Hypothalamic Volume and Metabolism, Cognition, and Behavior in Patients With Amyotrophic Lateral Sclerosis.

Author

Michielsen A, van Veenhuijzen K, Janse van Mantgem MR, van Es MA, Veldink JH, van Eijk RPA, van den Berg LH, and Westeneng HJ

Subjects
Humans, Male, Female, Middle Aged, Aged, Cross-Sectional Studies, Longitudinal Studies, Disease Progression, Cognition physiology, Adult, Energy Metabolism physiology, Amyotrophic Lateral Sclerosis metabolism, Amyotrophic Lateral Sclerosis diagnostic imaging, Amyotrophic Lateral Sclerosis pathology, Hypothalamus diagnostic imaging, Hypothalamus metabolism, Hypothalamus pathology, Magnetic Resonance Imaging
Abstract

Background and Objectives: Dysfunction of energy metabolism, cognition, and behavior are important nonmotor symptoms of amyotrophic lateral sclerosis (ALS), negatively affecting survival and quality of life, but poorly understood. Neuroimaging is ideally suited to studying nonmotor neurodegeneration in ALS, but few studies have focused on the hypothalamus, a key region for regulating energy homeostasis, cognition, and behavior. We evaluated, therefore, hypothalamic neurodegeneration in ALS and explored the relationship between hypothalamic volumes and dysregulation of energy metabolism, cognitive and behavioral changes, disease progression, and survival., Methods: Patients with ALS and population-based controls were included for this cross-sectional and longitudinal MRI study. The hypothalamus was segmented into 5 subregions and their volumes were calculated. Linear (mixed) models, adjusted for age, sex, and total intracranial volume, were used to compare hypothalamic volumes between groups and to analyze associations with metabolism, cognition, behavior, and disease progression. Cox proportional hazard models were used to investigate the relationship of hypothalamic volumes with survival. Permutation-based corrections for multiple hypothesis testing were applied to all analyses to control the family-wise error rate., Results: Data were available for 564 patients with ALS and 356 controls. The volume of the anterior superior subregion of the hypothalamus was smaller in patients with ALS than in controls (β = -0.70 [-1.15 to -0.25], p = 0.013). Weight loss, memory impairments, and behavioral disinhibition were associated with a smaller posterior hypothalamus (β = -4.79 [-8.39 to -2.49], p = 0.001, β = -10.14 [-15.88 to -4.39], p = 0.004, and β = -12.09 [-18.83 to -5.35], p = 0.003, respectively). Furthermore, the volume of this subregion decreased faster over time in patients than in controls (β = -0.25 [0.42 to -0.09], p = 0.013), and a smaller volume of this structure was correlated with shorter survival (hazard ratio = 0.36 [0.21-0.61], p = 0.029)., Discussion: We obtained evidence for hypothalamic involvement in ALS, specifically marked by atrophy of the anterior superior subregion. Moreover, we found that atrophy of the posterior hypothalamus was associated with weight loss, memory dysfunction, behavioral disinhibition, and survival, and that this subregion deteriorated faster in patients with ALS than in controls. These findings improve our understanding of nonmotor involvement in ALS and could contribute to the identification of new treatment targets for this devastating disease.

Published
2024
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