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1. Pulmonary manifestations in patients with achalasia

Author

Janković Jelena, Milenković Branislava, and Skrobić Ognjan

Subjects
achalasia, functional pulmonary tests, respiratory symptoms, chest ct scan, Medicine
Abstract

Achalasia is a motility disorder caused by insufficient lower esophageal sphincter relaxation. Patients with achalasia, in addition to gastrointestinal symptoms, also have many respiratory symptoms. The mechanisms of lung involvement in those patients may include an extrinsic compression of the trachea from a dilated esophagus or aspiration of undigested food. The aim of this study is to evaluate clinical, structural and functional lung abnormalities in patients with achalasia. Respiratory symptoms can be caused by aspirated sour undigested contents that irritate the respiratory mucosa and retention of food in the lower esophagus can cause chest pain. The most common symptoms are cough, dyspnea, retrosternal pain, and dysphonia. Recurrent micro or macro-aspirations can cause structural changes in the airways and lung parenchyma such as fibrosis, nodular changes, and even pneumonia as an acute pulmonary manifestation. Compression on the bronchial tree can cause obstructive findings on spirometry tests but also restrictive findings can be associated with fibrosis. Decreased diffusion capacity of the lungs is a probable consequence of damage alveolar-capillary membrane with acidic gastric undigested contents. Respiratory symptoms, radiological and functional abnormalities are common in patients with achalasia. Awareness of this association is important in early diagnosis and treatment.

Published
2024
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2. ADA as main biochemical marker in patients with tuberculous effusion

Author

Janković Jelena, Ilić Branislav, Đurđević Nataša, and Jandrić Aleksandar

Subjects
adenosine deaminase, biomarkers, pleural effusion, tuberculosis, Biochemistry, QD415-436
Abstract

Tuberculous pleuritis (TP) is one of the most common extra-pulmonary tuberculosis form. Because of tuberculous pleurisy is hard to diagnose due to slow course of disease and lack of specificity in symptoms and diagnostic methods. In that reason, we need multidisciplinary approach and efficient biomarkers. Acid-fast bacilli (AFB) staining, cultures and pathophysiological biopsy finding from the majority of patients are positive only in less than 10%. Löwenstein culture results need time about 6-8 weeks what delays diagnosis. Adenosine deaminase (ADA) is biomarker with high sensitivity and specificity (more than 90%) and considered as gold standard of biomarkers in the diagnosis of TP. It is very hard to distinguish malignant from TP with lymphocyte predomination, but in patient with malignant pleural effusion the level of ADA is decreased, opposite from TP. ADA in pleural punctate is a fast, simple, efficient and economical way for clarification the etiology of the pleural effusion as tuberculous pleurisy. Also, many studies have proved the role of ADA in the response to treatment for tuberculosis at follow up period.

Published
2023
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3. Community acquired pneumonia: CAP

Author

Janković Jelena, Jandrić Aleksandar, and Jordanova Elena

Subjects
pneumonia, cap, diagnostics, treatment, Medicine (General), R5-920
Abstract

Introduction: Pneumonia is one of the most common diseases in modern medicine. It is an inflammation of the lung parenchyma caused by various agents or noxae. It is present equally in both sexes but does occur more commonly in people who are older, immunocompromised or have comorbidities (COPD, heart or kidney diseases). The most common causing microorganisms are Streptococcus pneumoniae, Haemophilus influenzea, Moraxella catarrhalis and Mycoplasma pneumoniae. Treatment decisions are based on physical examination results, lab analyses, sputum analysis, CURB65 and PSI scores. The patient is then treated as an in-patient or an out-patient. Treatment can be pharmacological or non-pharmacological. Patients are treated pharmacologically with combined antibiotic therapy according to antibiogram results or, more commonly, empirically. Since a high mortality rate from pneumonia persists worldwide, adequate and timely treatment of these patients is of the utmost importance.

Published
2022

4. Application of the environmentally friendly technology for the removal of PCBs from mineral oils and power transformers to achieve very low values of PCBs for repair and materials recycling

Author

Mihajlović Draginja, Janković Jelena, Vasović Valentina, Ivančević Vladimir, and Lukić Jelena

Subjects
power transformer, polychlorinated biphenyls (pcb), environmentally closed, transformer repair, recycling, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

The Republic of Serbia signed and ratified the Stockholm Convention on Persistent Organic Pollutants. Law on ratification of the Stockholm Convention was adopted and actions were defined through the National Implementation Plan and the Action Plan. On their basis Project Proper Management and Final Disposal of Polychlorinated Biphenyls (PCBs) was created. Institute Nikola Tesla (INT) participated in the realization of the project. In the period from 2015 to 2022, 601 tons of PCB oil was successfully decontaminated by the INT mobile plant, i.e. the PCB content was below 50 mg/kg, which classified the power transformers (PT) as non-contaminated [1,2]. If PT becomes waste or in case of necessary repair or oil regeneration, the required limit value is 10 mg/kg. According to data from INT database there are still 2637 PTs containing PCBs in the concentration range of 2 to 50 mg/kg. In this paper application of the environmentally closed INT decontamination technology for achieving low values of PCB in the oil is shown.

Published
2022
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5. Airway inflammation in patients with bronchiectasis

Author

Đurđević Nataša, Milenković Branislava, Janković Jelena, Mitić Javorka, Belić Slobodan, Jordanova Elena, and Baralić Marko

Subjects
bronchiectasis, infection, inflammation, Medicine (General), R5-920
Abstract

Bronchiectasis is a chronic lung disease characterized by an abnormal dilation of the bronchial lumen caused by weakening or destruction of the muscle or elastic components of the bronchial wall, decreased mucous clearance and frequent infections of the respiratory tract. The golden standard for bronchiectasis diagnosis is high-resolution computed tomography (HRCT) of the chest. Inflammation holds a central role in the development of structural lung changes, as well as airway and lung parenchyma damage. Infection and colonization of the respiratory tract contribute to increased inflammation and further damage to the lung. Upon entry into the respiratory tract, the pathogens activate epithelial cells, macrophages and dendritic cells. Activated inflammatory cells secrete chemical mediators which activate the immune response and thus allow the phagocytosis of pathogens. Early diagnosis, appropriate treatment and interruption of the vicious circle between infection and inflammation in patients suffering from bronchiectasis, prevent the development of structural changes to the airways.

Published
2021
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6. Characterization of insulation papers using FTIR-ATR spectroscopy

Author

Planojević Jelena, Lukić J., Vasović Valentina, Mihajlović D., Janković Jelena, and Kovačević Neda

Subjects
power transformer, solid paper insulation, thermally upgraded paper, ft-atr spectroscopy, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

The need to increase the productivity and capacity of power transformers has conditioned the production of insulating papers of a higher thermal class. For this purpose, various techniques of solid insulation modification were applied, which enable the increase in thermal and chemical stability of the insulating paper during the operation of the transformer. The applied additives, primarily dicyandiamide (DICY) and polyacrylamide (PAM), are one form of cellulose modification in the final stages of paper production. A significant difference between the papers is the nitrogen content in the paper, which is characterized by the addition of amine compounds (additives). The paper presents the application of infrared spectroscopy with totally attenuated reflection (FTIR-ATR) in the characterization of paper samples. The aim is to observe the difference between regularly kraft and thermally upgraded paper reflected in the presence or absence of characteristic functional groups for additives. The strip identification at 2194-2154 cm-1 confirmed the presence of dicyandiamide additives (DICY) in the spectrum of the sample of thermally upgraded paper, which is different compared with the spectrum of regular kraft paper.

Published
2021
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7. Solving the problem of exploitation of transformers with corrosive sulfur by oil desulfurization using a strong inorganic base and organic solvent

Author

Kolarski Dejan, Janković Jelena, Mihajlović Draginja, Kovačević Neda, and Lukić Jelena

Subjects
corrosive sulfur, dbds, corrosion, desulfurization, mineral insulating oil, power transformers, insulating fluids, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

Most power transformer failures are associated with the presence of corrosive sulfur compounds in mineral insulating oil, of which dibenzyl disulfide (DBDS) is the best known and most widespread corrosive sulfur compound. The oil of failed transformers usually contained DBDS, a compound with a pronounced affinity for the formation of copper (I) sulfide (Cu2S). Copper (I) sulfide is a compound that does not dissolve in oil, conducts electricity, and can be deposited on the paper insulation or copper conductor of the transformer. Created conductive paths between the windings can initiate turn-to-turn breakdown and failure of the transformer. Several technological procedures have been developed as a solution to oil corrosivity. The application of desulfurization technology developed by the Electrical Engineering Institute "Nikola Tesla" enables the efficient removal of DBDS and aging products from mineral insulation oils.

Published
2021
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8. Syncope as a dominant symptom of pulmonary embolism

Author

Mitić Javorka, Đurđević Nataša, Janković Jelena, Vešović Radomir, Tabaković Dejan, Baralić Marko, Jordanova Elena, and Janković Radmila

Subjects
syncope, embolism, thrombosis, Medicine (General), R5-920
Abstract

Introduction/aim Clinical signs and symptoms of pulmonary embolism (PE) are non-specific, which is why it is commonly not diagnosed on time or sometimes not diagnosed at all. We are presenting a case of pulmonary embolism manifesting with syncope as a dominant symptom. Case report A 74-year-old female patient was hospitalized at the Clinic for Pulmonary Diseases with PE manifested with syncope. At admission, she was afebrile, tachypneic, with normal cardiac function and normal blood tension. Upon auscultation, breathing was muffled with late inspiration crackles above the base of the left lung. There were no other significant findings. The chest X-ray recorded at admission showed a non-homogenous shadow towards the base of the left lung and minimal pleural effusion. The ECG and echocardiography findings were normal. Partial respiratory insufficiency was verified by the acid-base balance analysis. Inflammatory markers were significantly elevated, with erythrocyte sedimentation rate of 30mm/h, fibrinogen of 8.62g/l and D-dimer of 18.6mg/l. Anticardiolipin IgG and IgM antibodies were negative, as well as beta-2 GPI IgG and IgM antibodies. An MDCT lung angiography was performed because of the elevated values of D-dimer and tachypnea, which showed multiple emboli of various sizes in the distal part of the right pulmonary artery and all lobar branches, as well as an embolus in the lobar branch for the lower lobe of the left lung. After a neurology consult, a head CT was ordered because the patient had suffered from loss of consciousness, but there were no pathological densities in the brain. Colour Doppler Ultrasonography of the blood vessels in the lower extremities showed organized thrombosis of the left femoral vein. A vascular surgeon was consulted and he prescribed anticoagulant therapy and an elastic compressive stocking, with control Colour Doppler Ultrasonography to be performed in six months. Conclusion Although syncope is an easily detectable symptom, it is still an unregulated crossroad of many an internal and neurological disease.

Published
2020

9. Validation of Serbian version of chronic obstructive pulmonary disease assessment test

Author

Milenković Branislava, Dimić-Janjić Sanja, Kotur-Stevuljević Jelena, Kopitović Ivan, Janković Jelena, Stjepanović Mihailo, Vukoja Marija, Ristić Snežana, and Davičević-Elez Žaklina

Subjects
pulmonary disease, chronic obstructive, surveys and questionnaires, serbia, comorbidity, forced expiratory volume, Medicine (General), R5-920
Abstract

Background/Aim. The Chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a simple and reliable tool designed to measure overall COPD related health status and complement physician assessment in routine clinical practice. Objective of this study was to evaluate the validity of the Serbian version of CAT. Methods. Study included 140 outpatients in the stable COPD, recruited from two centres: Clinic for Pulmonology, Clinical Center of Serbia, Belgrade, and Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica. All patients completed pulmonary function testing – spirometry, the CAT and the modified Medical Research Council (mMRC) dyspnea scale at baseline visit. The CAT test-retest reliability was tested in 20 patients by the same investigator (physician). Results. We demonstrated that Serbian version of CAT had high internal consistency with Cronbach’s alpha 0.88. Test-retest analysis showed good correlation between CAT scores in two time points (Spearman’s ρ = 0.681, p < 0.01). In our study the CAT correlated moderately to mMRC scale (ρ = +0.57), weakly to FEV1 (ρ -0.214), was positively related to number of exacerbations, but did not showed exact regularity with change in the Global Initiative for Chronic Obstructive lung disease (GOLD) stage. Conclusion. The Serbian version of CAT is a reliable, simple and easy-to-use tool that can be used in everyday clinical practice to assess the health status of COPD patients in Serbia.

Published
2020
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10. The rare manifestation of pulmonary artery agenesis

Author

Radovanović Dragan, Janković Jelena, Popović Marko, and Stjepanović Mihailo

Subjects
pulmonary arteries, hemoptysis, computed tomography, angiogenesis, Medicine
Abstract

Introduction. Unilateral absence of pulmonary artery is a rare vascular malformation. Because of this anomaly, the lungs are supplied by the system of collateral arteries. Case outline. We present a case of the right pulmonary artery agenesis in a female patient. She was admitted to the hospital because of hemoptysis. A computed tomography scan revealed a congenital malformation – the right lung was smaller in size, the right principal pulmonary artery had not been developed along with aberrant tortuous blood vessels. Conclusion. Symptomatic therapy was applied in the case of our patient. There was no need for any surgical treatment. However, in case of massive hemoptysis embolisation or lobectomy/ pneumonectomy will probably be applied.

Published
2019
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11. Validation of the Serbian version of the Asthma Control Test

Author

Milenković Branislava, Ristić Snežana, Mirović Danijela, Dimić-Janjić Sanja, Janković Jelena, Đurđević Nataša, Davičević-Elez Žaklina, and Lukić Tamara

Subjects
asthma, surveys and questionnaires, serbia, Medicine (General), R5-920
Abstract

Background/Aim. Asthma still remains poorly controlled in the majority of patients. The Asthma Control Test (ACT) is a short and useful patient-administered questionnaire for identification of patients with poor asthma control in clinical settings. The aim of this study was to validate a Serbian version of the ACT in the adults with asthma. Methods. A total of 250 consecutive adult asthmatic patients were recruited in a prospective observational study. The exclusion criteria were chronic respiratory disease and acute respiratory tract infection in preceding 4 weeks. Results. The spirometry and ACT questionnaire were performed on the baseline visit and 6 months later. The ACT test was completed by 98.8% of patients with the mean time of completion of 4.5 minutes. The correlation of ACT score and lung function parameters (forced expiratory volume in 1 second – FEV1 and forced vital capacity – FVC) was significant (p = 0.016 and p = 0.002, respectively). A change in the ACT scores between baseline and 6- months visit was not associated with a change in FVC and FEV1. The ACT score had excellent diagnostic accuracy according to the physicians asthma control classification and even outstanding accuracy according to the patients’ classification. Conclusion. The results of this study confirm the reliability, validity and accuracy of Serbian version of the ACT, contributing to established value of original ACT test and with consistent findings as the previously reported validity of ACT in other languages. Therefore, it should be utilized more in everyday clinical practice as a useful and reliable tool of asthma control assessment.

Published
2019
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12. Evaluation of paper insulation of power transformers based on the content of 2-furfural in mineral oil corrected to a reference temperature of 20ºc

Author

Vasović Valentina, Mihajlović Draginja, Janković Jelena, and Lukić Jelena

Subjects
power transformers, paper insulation, degradation, furan derivatives, lifetime, condition assessment, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

The reliability of power transformers operation largely depends on the insulation system condition, especially on the condition of paper insulation. Determining the condition of paper insulation of transformers in use cannot be made by direct measurements. The most common way of assessing the paper insulation condition is by analyzing the content of 2-furfural dissolved in the insulating oil and by applying correlations between the degree of paper polymerization and the 2-furfural content in the insulating oil. The concentration of 2-furfural in the oil depends on the moisture content of the insulation system and the oxygen and acid content in the oil. In order to gain a better insight into the cumulative content of 2-furfural produced by paper degradation, excluding changes in the 2-furfural content caused by migration between paper and oil at different operating temperatures, dependence of the degree of polymerization of kraft paper to 2-FAL content in the oil, corrected to a reference temperature of 20°C, for a moisture content in cellulose of 1-1.5% and 3-4% is presented in this paper. This diagram has been verified on 4 transformers according to available data from the database of the Electrical Engineering Institute Nikola Tesla. In the future, this diagram should be completed for moisture content of 2.5% in cellulose insulation.

Published
2019

13. Application of patented technology for solving the problem of PCB contamination and corrosive sulfur in power transformers

Author

Janković Jelena, Mihajlović Draginja, Kovačević Neda, Vasović Valentina, and Lukić Jelena

Subjects
power transformer, polychlorinated biphenyl's (PCB), corrosive sulphur, dibenzyl disulphide (DBDS), dechlorination, desulphurization, regeneration, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

The exploitation of PCB contaminated power transformers and those which contain corrosive sulphur is related to the greatest risks to the environment, due to possible environmental accidents and faults and failures of transformers. The equipment contaminated with PCB require special attention, more frequent testing of transformer condition and control of oil leaking, while for corrosive oils standards and requirements defined in CIGRE TB 378, CIGRE TB 625, IEC 60296 and IEC 60422 are restrictive for the use of corrosive oils. Overview of the problems with PCB contaminated equipment and corrosive sulphur is provided in accordance to the latest knowledge in these areas. PCB decontamination, desulfurization and oil regeneration process is described by the application of patented technology developed in the 'Nikola Tesla' Institute. Summarized results of decontamination process of 310 PCB contaminated power transformers with different voltage levels and power and removal of corrosive sulphur from 29 transformers show the efficiency of this process for simultaneous removal of PCB, corrosive sulphur and oil ageing products.

Published
2018

14. Specific measures of 'greening' the unemployment insurance system

Author

Janković Jelena

Subjects
unemployment insurance, education, work, eco-transition, green-collar jobs, Law
Abstract

The path to the effective protection against unemployment is tiled with a number of normative and practical challenges. Arguing that environmental protection and unemployment protection are challenges which should be addressed together, the author's research is aimed at finding the answer to the question concerning the role of unemployment insurance system in the process of eco-transition. This paper is an attempt to design eco-strategic framework for the development of skills that match the current and future needs of society, with special emphasis on the role of employment services. Sustainable development is possible only with the active participation and engagement of the workforce. Green jobs and made-green jobs, still named green-collar jobs, are the jobs of the future labour market. Employment policy makers should be well prepared for the challenge of changing the structure of the workforce in the conditions of ecologically clean industry. Anyway, exaggerated expectations that the changed structure of workforce will respond to all challenges of eco-transition should be limited. However, from the design of a strategic framework for skills development and integration of education and work, minimal results in term of reducing the unemployment rate can be expected.

Published
2016
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15. The influence of antibiotics and statins on inflammation in coronary disease

Author

Stojanović Radan M., Vasiljević Zorana, Prostran Milica Š., Radovanović Mina, Stefanović Branislav, Radovanović Nebojša, Janković Jelena, Lakičević Mirko, Mitrović Predrag, Lasica Ratko, Nešić Zorica I., Todorović Zoran, and Stojanov Marina

Subjects
cardiovascular diseases, arteriosclerosis, inflammation mediators, anti-bacterial agents, hydroxymethylglutaryl - CoA reductase inhibitors, Medicine (General), R5-920
Published
2005
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20. Integration of migrant and refugee data in health information systems in Europe: advancing evidence, policy and practice

Author

Bozorgmehr, Kayvan, primary, McKee, Martin, additional, Azzopardi-Muscat, Natasha, additional, Bartovic, Jozef, additional, Campos-Matos, Ines, additional, Gerganova, Tsvetelina-Ivanova, additional, Hannigan, Ailish, additional, Janković, Jelena, additional, Kállayová, Daniela, additional, Kaplan, Josiah, additional, Kayi, Ilker, additional, Kondilis, Elias, additional, Lundberg, Lene, additional, Mata, Isabel de la, additional, Medarević, Aleksandar, additional, Suvada, Jozef, additional, Wickramage, Kolitha, additional, and Puthoopparambil, Soorej Jose, additional

Published
2023
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22. Exploring Black and South Asian women’s experiences of help-seeking and engagement in perinatal mental health services in the UK

Author

Conneely, Maev, primary, Packer, Katy C., additional, Bicknell, Sarah, additional, Janković, Jelena, additional, Sihre, Harpreet Kaur, additional, McCabe, Rosemarie, additional, Copello, Alex, additional, Bains, Kiren, additional, Priebe, Stefan, additional, Spruce, Amy, additional, and Jovanović, Nikolina, additional

Published
2023
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23. Integration of migrant and refugee data in health information systems in Europe : advancing evidence, policy and practice

Author

Bozorgmehr, Kayvan, McKee, Martin, Azzopardi-Muscat, Natasha, Bartovic, Jozef, Campos-Matos, Ines, Gerganova, Tsvetelina-Ivanova, Hannigan, Ailish, Janković, Jelena, Kállayová, Daniela, Kaplan, Josiah, Kayi, Ilker, Kondilis, Elias, Lundberg, Lene, Mata, Isabel de la, Medarević, Aleksandar, Suvada, Jozef, Wickramage, Kolitha, Puthoopparambil, Soorej Jose, Bozorgmehr, Kayvan, McKee, Martin, Azzopardi-Muscat, Natasha, Bartovic, Jozef, Campos-Matos, Ines, Gerganova, Tsvetelina-Ivanova, Hannigan, Ailish, Janković, Jelena, Kállayová, Daniela, Kaplan, Josiah, Kayi, Ilker, Kondilis, Elias, Lundberg, Lene, Mata, Isabel de la, Medarević, Aleksandar, Suvada, Jozef, Wickramage, Kolitha, and Puthoopparambil, Soorej Jose

Abstract

Coverage of migrant and refugee data is incomplete and of insufficient quality in European health information systems. This is not because we lack the knowledge or technology. Rather, it is due to various political factors at local, national and European levels, which hinder the implementation of existing knowledge and guidelines. This reflects the low political priority given to the topic, and also complex governance challenges associated with migration and displacement. We review recent evidence, guidelines, and policies to propose four approaches that will advance science, policy, and practice. First, we call for strategies that ensure that data is collected, analyzed and disseminated systematically. Second, we propose methods to safeguard privacy while combining data from multiple sources. Third, we set out how to enable survey methods that take account of the groups’ diversity. Fourth, we emphasize the need to engage migrants and refugees in decisions about their own health data. Based on these approaches, we propose a change management approach that narrows the gap between knowledge and action to create healthcare policies and practices that are truly inclusive of migrants and refugees. We thereby offer an agenda that will better serve public health needs, including those of migrants and refugees and advance equity in European health systems.

Published
2023
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30. New words and gender equality in Serbian – does discrimination exist?

Author

Đorđević, Vesna, Janković, Jelena, and Nikolić, Marina

Subjects
media text, social masculine titles, social feminine titles, Serbian language, gender-sensitive language, gender equality, discrimination
Abstract

We examined the general attitude to new feminine titles, as it formed in the media in 2021, and the overall image of social feminine titles currently prevalent in the Serbian media, all by way of ascertaining the reasons for acceptance or non-acceptance of new social feminine titles that were articulated in the media. Having defined the necessary terms (discrimination, gender equality, social feminine title and so on) and after a brief review of the social context that made social feminine titles a hot topic in the Serbian media in 2021, we analysed the relevant media texts that present the various positions on social feminine titles. The method of qualitative content analysis was applied, as it was deemed the most fitting methodological procedure for extracting both the arguments put forward in favour of, and those against social feminine title use. The research corpus consisted of media texts and official announcements by Serbian linguistic institutions on the subject of social feminine titles, collected from January to September of 2021. The basic assumption was that the dominant attitude in the media texts would be against new feminine title use, but also that both supporters and opponents of new social feminine titles would feel discriminated against, whether the discrimination came via opposition to or, conversely, via obligatory and consistent use of these terms.

Published
2022

31. Rešavanje problema eksploatacije transformatora sa korozivnim sumporom desulfurizacijom ulja primenom jake neorganske baze i organskog rastvarača

Author

Kolarski, Dejan, Janković, Jelena, Mihajlović, Draginja, Kovačević, Neda, and Lukić Jelena

Subjects
korozivni sumpor, korozija, DBDS, izolacioni fluidi, desulfurizacija, mineralno izolaciono ulje, energetski transformatori
Abstract

Jedan od značajnih rizika havarije energetskih transformatorima je prisustvo korozivnih sumpornih jedinjenja u mineralnom izolacionom ulju od kojih je dibenzil-disulfid (DBDS) najpoznatije i najrasprostranjenije korozivno jedinjenje sumpora. Havarije transformatora usled prisutnih korozivnih jedinjenja sumpora u ulju i to najčešće dibenzil disulfide jedinjenja koje ima izražen afinitet za stvaranje elektro-provodnih bakar (I) sulfida (Cu2S) bile su manifestovane u najvećem broju slučajeva kao međuzavojni proboj čvrste izolacije, električna pražnjenja i proboj kroz ulje. Nastali bakar (I) sulfid je jedinjenje koje se ne rastvara u ulju, provodi električnu energiju i može da se taloži na papirnoj izolaciji transformatora pri čemu nastaju elektroprovodne staze između navojaka namotaja i dolazi do proboja čvrste izolacije namotaja, odnosno havarije transformatora. Za rešavanje problema korozivnosti ulja razvijeno je nekoliko tehnoloških postupaka obrade korozivnog ulja. Primenom tehnologije desulfurizacije koju je razvio Elektrotehnički institut ’Nikola Tesla’ omogućeno je efikasno uklanjanje DBDS-a i produkata starenja iz mineralnog izolacionog ulja.&nbsp

Published
2021

32. Karakterizacija izolacionih papira primenom FTIR-ATR spektroskopije

Author

Planojević, Jelena, Lukić, Jelena, Vasović, Valentina, Mihajlović, Draginja, Janković, Jelena, and Kovačević, Neda

Subjects
FTIR-ATR spektroskopija, termički nadograđen papir, transformator, čvrsta papirna izolacija
Abstract

Potreba za povećanjem produktivnosti i kapaciteta energetskih transformatora uslovila je proizvodnju izolacionih papira više termičke klase. U tu svrhu se primenjuju najrazličitije tehnike modifikacije čvrste izolacije koje omogućavaju povećanje termičke i hemijske stabilnosti izolacionog papira tokom eksploatacije transformatora. Dodatak aditiva, pre svega dicijandiamida (DICY) i poliakrilamida (PAM), predstavlјa jedan od oblika modifikacije celuloze u završnim fazama proizvodnje papira. Značajnu razliku među papirima predstavlјa sadržaj azota u papiru koji karakteriše dodavanje aminskih jedinjenja (aditiva). U radu je prikazana primena infracrvene spektroskopije sa totalno oslablјenom refleksijom (FTIR-ATR) u karakterizaciji uzoraka papira kao i uočavanju razlika između običnog kraft i termički nadograđenog papira koja se ogleda u prisustvu ili odsustvu karakterističnih funkcionalnih grupa za aditive. Identifikacijom traka na 2194-2154 cm-1 potvrđeno je prisustvo aditiva dicijandiamina (DICY) u spektru uzorka termički nadograđenog papira što predstavlјa razliku u odnosu na spektar običnog kraft papira.

Published
2021

34. Validation of Serbian version of chronic obstructive pulmonary disease assessment test

Author

Milenković, Branislava, Milenković, Branislava, Dimić Janjić, Sanja, Kotur-Stevuljević, Jelena, Kopitović, Ivan, Janković, Jelena, Stjepanović, Mihailo, Vukoja, Marija, Ristić, Snežana, Davičević-Elez, Žaklina, Milenković, Branislava, Milenković, Branislava, Dimić Janjić, Sanja, Kotur-Stevuljević, Jelena, Kopitović, Ivan, Janković, Jelena, Stjepanović, Mihailo, Vukoja, Marija, Ristić, Snežana, and Davičević-Elez, Žaklina

Abstract

Uvod/Cilj. Upitnik za procenu hronične opstruktivne bolesti pluća (HOBP) (engl. COPD Assessment Test - CAT) je jednostavan i pouzdan test namenjen za merenje ukupnog zdravstvenog stanja bolesnika sa HOBP i koristan je za upotrebu u svakodnevnoj kliničkoj praksi. Cilj ovog istraživanja bio je da se proceni validnost i opravdanost primene srpske verzije CAT. Metode. U studiji je učestvovalo 140 bolesnika u stabilnom stanju HOBP, ispitivanih u ambulantnim uslovima na Klinici za pulmologiju, Kliničkog centra Srbije u Beogradu i Institutu za plućne bolesti Vojvodine u Sremskoj Kamenici. Tokom prvog pregleda bolesnicima je učinjeno ispitivanje plućne funkcije (spirometrija), popunili su CAT upitnik i mMMR (modified Medical Research Council) skalu za procenu stepena dispneje. Pouzdanost CAT test-retesta je ispitivana kod 20 bolesnika od strane istog istraživača. Rezultati. Pokazali smo da srpska verzija CAT ima visoku internu konzistentnost sa Cronbach-ovim alfa 0.88. Test-retest analiza pokazala je dobru korelaciju između CAT rezultata u dve vremenske tačke (Spearmanov r = 0,681; p < 0,01). CAT je umereno korelirao sa mMRC skalom (r = + 0,57), blago sa forsiranim ekspiratornim volumenom u prvoj sekundi (FEV1), (r -0,214), uz pozitivnu korelaciju sa ukupnim brojem pogoršanja HOBP, ali bez jasne regularnosti sa promenom GOLD (Global Initiative for Chronic Obstructive Lung Disease) stadijuma. Zaključak. Srpska verzija CAT je pokazala visoku internu konzistentnost i test-retest pouzdanost. Ona predstavlja pouzdano, jednostavno i lako sredstvo za upotrebu koje se može koristiti u svakodnevnoj kliničkoj praksi za procenu zdravstvenog stanja kod bolesnika sa HOBP u Srbiji., Background/Aim. The Chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a simple and reliable tool designed to measure overall COPD related health status and complement physician assessment in rou-tine clinical practice. Objective of this study was to evaluate the validity of the Serbian version of CAT. Methods. Study included 140 outpatients in the stable COPD, recruited from two centres: Clinic for Pulmonology, Clinical Center of Serbia, Belgrade, and Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica. All patients completed pulmonary function testing – spirometry, the CAT and the modified Medical Research Council (mMRC) dyspnea scale at baseline visit. The CAT test-retest reliability was tested in 20 patients by the same investigator (physician). Results.We demonstrated that Serbian version of CAT had high internal consistency with Cronbach’s alpha 0.88. Test-retest analysis showed good correlation between CAT scores in two time points (Spearman’s ρ = 0.681, p < 0.01). In our study the CAT correlated moderately to mMRC scale (ρ = +0.57), weakly to FEV1 (ρ -0.214), was positively related to number of exacerbations, but did not showed exact regularity with change in the Global Initiative for Chronic Obstructive lung disease (GOLD) stage. Conclusion.The Serbian version of CAT is a reliable, simple and easy-to-use tool that can be used in everyday clinical practice to assess the health status of COPD patients in Serbia.

Published
2020

37. Етимологија у часопису 'Наш језик'

Author

Janković, Jelena D., Milanović, Aleksandar, Loma, Aleksandar, Stanišić, Vanja, Janković, Jelena D., Janković, Jelena D., Milanović, Aleksandar, Loma, Aleksandar, Stanišić, Vanja, and Janković, Jelena D.

Abstract

Предмет дисертације су етимолошки подаци који се налазе у чланцимаобјављеним у лингвистичком часопису „Наш језик“ у временском распону од1932/1933. до 2013. године. Међу његовим корицама су се, у складу с програмомчасописа, нашли радови посвећени изучавању и нормирању српског (ранијесрпско-хрватског) књижевног језика, решавању питања језичке културе, неговањуте културе и усмеравању правца њеног даљег развитка. Иако је у „Нашем језику“објављен мањи број етимолошких студија, часопис се показао као богат изворетимолошких података, а под тим подразумевамо сваку информацију која се тичепорекла, развоја и/или историје одређене речи, израза или синтаксичкеконструкције..., The subject of this dissertation is the etymological information found in thepapers published in the linguistic journal Naš jezik from 1932/1933 to 2013. Inaccordance with the journal program, the papers published in these volumes are dealingwith topics such as study and standardization of the Serbian (formerly Serbo-Croatian)literary language; they are also addressing various language culture issues, fosteringlanguage culture as well as steering the direction of its further development. Eventhough only a smaller number of etymological studies have been published in thejournal Naš jezik, it has proven to be a rich source of etymological information, and bythat, we mean any information concerning origin, development, and/or history of aspecific word, phrase or syntactic construction...

Published
2017

38. Hypersensitivity reactions to antiepileptic drugs in children

Author

Atanasković-Marković, Marina, Janković, Jelena, Tmušić, Vladimir, Gavrović-Jankulović, Marija, Ćirković-Veličković, Tanja, Nikolić, Dimitrije, Škorić, Dejan, Atanasković-Marković, Marina, Janković, Jelena, Tmušić, Vladimir, Gavrović-Jankulović, Marija, Ćirković-Veličković, Tanja, Nikolić, Dimitrije, and Škorić, Dejan

Abstract

Background: Antiepileptic drugs (AEDs) can cause hypersensitivity reactions in children. These reactions are mainly cutaneous, self-limiting, and benign, but life-threatening severe cutaneous adverse reactions can occur. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions, if a drug is taken at the same time. The aims of our study were to confirm or rule out the diagnosis of hypersensitivity reactions to AEDs in children and to detect an infection which mimics these reactions. Methods: A prospective survey was conducted in a group of 100 children with histories of hypersensitivity reactions to AEDs by performing patch tests, delayed-reading intradermal test, and, in case of negative results, challenge test. In all children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. Results: Maculopapular exanthema and delayed-appearing urticaria were the most reported hypersensitivity reactions to AEDs. Sixty-six (66%) of 100 children had confirmed hypersensitivity reactions to AEDs. Fifty-nine children had positive patch test. No children had positive challenge tests. The most common AEDs causing hypersensitivity reactions were carbamazepine (45.4%) and lamotrigine (43.6%). Thirty-two children had positive tests for viruses or M pneumoniae, and nine of them had also a positive allergy work-up. Conclusion: Considering that there are no specific tests to distinguish between a viral infection and hypersensitivity reactions to AEDs in the acute phase, a diagnostic work-up should be performed in all children with suspected hypersensitivity reactions to AEDs, as well as infectious agent study, to remove a false label of hypersensitivity.

Published
2019

40. Etymology in journal 'Naš jezik' ; Этимология в журнале 'Наш језик'

Author

Janković, Jelena D., Milanović, Aleksandar, Loma, Aleksandar, and Stanišić, Vanja

Subjects
часопис „Наш језик“, Russian loanword, etymology, lexicology, Czech loanword, српски (српско-хрватски) језик, лексикологија, русизам, Serbian (Serbo-Croatian), етимологија, diachronic linguistics, дијахронијска лингвистика, бохемизам, linguistic journal Naš jezik
Abstract

Предмет дисертације су етимолошки подаци који се налазе у чланцима објављеним у лингвистичком часопису „Наш језик“ у временском распону од 1932/1933. до 2013. године. Међу његовим корицама су се, у складу с програмом часописа, нашли радови посвећени изучавању и нормирању српског (раније српско-хрватског) књижевног језика, решавању питања језичке културе, неговању те културе и усмеравању правца њеног даљег развитка. Иако је у „Нашем језику“ објављен мањи број етимолошких студија, часопис се показао као богат извор етимолошких података, а под тим подразумевамо сваку информацију која се тиче порекла, развоја и/или историје одређене речи, израза или синтаксичке конструкције... The subject of this dissertation is the etymological information found in the papers published in the linguistic journal Naš jezik from 1932/1933 to 2013. In accordance with the journal program, the papers published in these volumes are dealing with topics such as study and standardization of the Serbian (formerly Serbo-Croatian) literary language; they are also addressing various language culture issues, fostering language culture as well as steering the direction of its further development. Even though only a smaller number of etymological studies have been published in the journal Naš jezik, it has proven to be a rich source of etymological information, and by that, we mean any information concerning origin, development, and/or history of a specific word, phrase or syntactic construction...

Published
2017

42. Analiza proteinskih i genetičkih biomarkera u preoperativnoj i postoperativnoj diferencijalnoj dijagnostici tumora štitaste žlezde

Author

Janković, Jelena R., Gavrović-Jankulović, Marija, Paskaš, Svetlana, Tatić, Svetislav, and Nikolić, Milan

Subjects
FNAB, caveolin-1, biomarkeri, diagnosis, EGFR, thyroid cancer, biomarkers, karcinom štitne žlezde, dijagnostika, kaveolin-1, BRAF
Abstract

Karcinom štitne žlezde je najčešće maligno boljenje endokrinih organa. Incidenca tiroidnog kancera je u poslednih trideset godina porasla u gotovo svim regijama u svetu, i ovaj trend zabeležen je i u Srbiji. Citološka analiza uzoraka dobijenih biopsijom tankom iglom (FNAB) omogućava diferencijalnu dijagnostiku ovih lezija, međutim u oko 30% slučajeva daje neodređene rezultate. Pacijenti kojima se ne može postaviti jasna dijagnoza se šalju na dijagnostičku lobektomiju i kod više od trećine operisanih se dijagnostikuje indolentna benigna lezija koja nije zahtevala operativni tretman. Pacijenti sa malignitetom, sa druge strane, bivaju podvrgnuti i drugoj, terapeutskoj operaciji. Postoperativna dijagnostika, iako preciznija, takođe nije bez nedostataka. Kriterijumi koji razdvajaju benigne od malignih lezija folikularne arhitekture nisu jasno definisani. Ovi problemi ukazuju na potrebu za dodatnim testovima, odnosno pomoćnim dijagnostičkim markerima. Dosadašnje studije su analizirale različite proteinske i genetičke markere, kao i njihove kombinacije. Neki od njih su pokazali dobre dijagnostičke performanse. Ipak, različiti nedostaci prate upotrebu ovih markera u klinici - imunohistohemijsko određivanje proteinskih biomarkera podleže subjektivnosti u ocenjivanju, dok korišćenje mutacija kao genetičkih markera pokazuje visoku specifičnost, ali nisku osetljivost jer mnogi karcinomi ne nose mutacije. U ovoj disertaciji su analizirani biomarkeri mereni na nivou DNK, RNK i proteina. Na postoperativnim uzorcima je imunohistohemijski određena ekspresija i tkivna lokalizacija proteina kaveolina-1, kao i prisustvo BRAF V600E. U uzorcima biopsija je pored pomenutih markera, određeno i prisustvo RET/PTC1 i 3 hromozomskih rearanžmana i EGFRvIII mutacije. Ekspresija gena za EGFR je određena u uzorcima grupisanim prema ekspresiji kaveolina-1 i prisustva BRAF V600E mutacije, i analizirane su međusobne korelacije ovih markera, činilaca MAPK signalnog puta. Markeri koji su pokazali dobru diskriminatorsku moć su analizirani zajednički i određen je dijagnostički potencijal ove kombinacije. Analizom korelacija sa kliničko-patološkim parametrima, određen je njihov prognostički značaj. Rezultati ove disertacije su pokazali da se proteinska ekspresija kaveolina-1 može upotrebiti kao dijagnostički marker za razlikovanje histotipova slične morfologije, i za diskriminaciju benignih od malignih lezija. Utvrđeno je da su nivoi kaveolina-1 u epitelnom odeljku u pozitivnoj korelaciji sa limfnim metastazama, suprotno od stromalnih koji korelišu negativno sa dubinom infiltracije karcinoma. Ovo ukazuje na potencijalno različite uloge kaveolina-1 u kancerogenezi u zavisnosti od ćelijskog konteksta. BRAF V600E mutacija je detektovana gotovo isključivo u malignim lezijama, i utvrđeno je da kod papilarnog tiroidnog karcinoma pozitivno koreliše sa parametrima agresivnosti. Ova mutacija takođe pozitivno koreliše sa ekspresijom kaveolina-1 u epitelnom tkivnom odeljku, a negativno sa ekspresijom stromalnog kaveolina-1... Thyroid cancer is the most common malignancy of the endocrine system. Over the last 30 years the incidence of thyroid cancer has been increasing in almost all regions of the world, and this trend has also been recorded in Serbia. Fine Needle Aspiration Biopsy (FNAB) has enabled preoperative differential diagnosis of these lesions, however, 30% of aspirations yield indeterminate results. Patients with nodules that are not clearly benign or malignant undergo diagnostic lobectomy, and more that a third of them prove to have benign, indolent lesions that did not require surgical treatment. Patients diagnosed with malignancy, on the other hand, are referred to a second, therapeutic surgery. Postoperative diagnosis is more precise, yet, it has drawbacks. The criteria for differentiating benign from malignant lesions with follicular architecture is not well defined. The aforementioned obstacles stress the need for additional tests, i.e. the use of adjunct diagnostic biomarkers. A large number of potential protein and genetic biomarkers, as well as their combinations, has been analysed and some of them proved to have good diagnostic performances. Still, there are obstacles in applying these biomarkers in the clinical setting – immunohistochemical scoring of protein markers is prone to subjective interpretation, while genetic mutation testing, although high in specificity, shows low sensitivity given that many malignant lesions do not bear any known mutations. The aim of this dissertation was the evaluation of potential thyroid cancer biomarkers measured on DNA, RNA and protein level. Postoperative tissue samples were used for immunohistochemical analysis of the expression and tissue localisation of the protein caveolin-1, and determination of the presence of BRAF V600E mutation. Biopsy samples were used for the analysis of the previously mentioned biomarkers, as well as to determine the frequency of RET/PTC1 and 3 chromosomal rearrangements and EGFRvIII mutation. After dividing the samples in groups according to caveolin-1 expression and BRAF genotype, EGFR gene expression was measured. The mutual associations of these markers, components of the MAPK signaling pathway, were also determined. Markers with a good discriminatory power were analysed in combination. Their associations with clinico-pathological parameters were used to determine their prognostic value. The results of this dissertation have shown that protein expression of caveolin-1 can be used for differentiating lesions with similar histological features, as well for discriminating benign from malignant nodules. The levels of caveolin-1 in epithelial tissue compartment of malignant lesions correlate positively with the presence of lymphatic tumor spreading, while, contrary to that, stromal caveolin-1 correlates negatively with the degree of tumor infiltration. This indicates that caveolin-1 has different roles in cancer progression depending on the cellular context...

Published
2017

43. Analysis of protein and genetic markers in preoperative and postoperative differential diagnosis of thyroid gland tumors

Author

Janković, Jelena, Gavrović-Jankulović, Marija, Paskaš, Svetlana, Tatić, Svetislav, and Nikolić, Milan

Subjects
FNAB, caveolin-1, biomarkeri, diagnosis, EGFR, thyroid cancer, biomarkers, karcinom štitne žlezde, dijagnostika, kaveolin-1, BRAF
Abstract

Karcinom štitne žlezde je najčešće maligno boljenje endokrinih organa. Incidenca tiroidnog kancera je u poslednih trideset godina porasla u gotovo svim regijama u svetu, i ovaj trend zabeležen je i u Srbiji. Citološka analiza uzoraka dobijenih biopsijom tankom iglom (FNAB) omogućava diferencijalnu dijagnostiku ovih lezija, međutim u oko 30% slučajeva daje neodređene rezultate. Pacijenti kojima se ne može postaviti jasna dijagnoza se šalju na dijagnostičku lobektomiju i kod više od trećine operisanih se dijagnostikuje indolentna benigna lezija koja nije zahtevala operativni tretman. Pacijenti sa malignitetom, sa druge strane, bivaju podvrgnuti i drugoj, terapeutskoj operaciji. Postoperativna dijagnostika, iako preciznija, takođe nije bez nedostataka. Kriterijumi koji razdvajaju benigne od malignih lezija folikularne arhitekture nisu jasno definisani. Ovi problemi ukazuju na potrebu za dodatnim testovima, odnosno pomoćnim dijagnostičkim markerima.Dosadašnje studije su analizirale različite proteinske i genetičke markere, kao i njihove kombinacije. Neki od njih su pokazali dobre dijagnostičke performanse. Ipak, različiti nedostaci prate upotrebu ovih markera u klinici - imunohistohemijsko određivanje proteinskih biomarkera podleže subjektivnosti u ocenjivanju, dok korišćenje mutacija kao genetičkih markera pokazuje visoku specifičnost, ali nisku osetljivost jer mnogi karcinomi ne nose mutacije.U ovoj disertaciji su analizirani biomarkeri mereni na nivou DNK, RNK i proteina. Na postoperativnim uzorcima je imunohistohemijski određena ekspresija i tkivna lokalizacija proteina kaveolina-1, kao i prisustvo BRAF V600E. U uzorcima biopsija je pored pomenutih markera, određeno i prisustvo RET/PTC1 i 3 hromozomskih rearanžmana i EGFRvIII mutacije. Ekspresija gena za EGFR je određena u uzorcima grupisanim prema ekspresiji kaveolina-1 i prisustva BRAF V600E mutacije, i analizirane su međusobne korelacije ovih markera, činilaca MAPK signalnog puta. Markeri koji su pokazali dobru diskriminatorsku moć su analizirani zajednički i određen je dijagnostički potencijal ove kombinacije. Analizom korelacija sa kliničko-patološkim parametrima, određen je njihov prognostički značaj.Rezultati ove disertacije su pokazali da se proteinska ekspresija kaveolina-1 može upotrebiti kao dijagnostički marker za razlikovanje histotipova slične morfologije, i za diskriminaciju benignih od malignih lezija. Utvrđeno je da su nivoi kaveolina-1 u epitelnom odeljku u pozitivnoj korelaciji sa limfnim metastazama, suprotno od stromalnih koji korelišu negativno sa dubinom infiltracije karcinoma. Ovo ukazuje na potencijalno različite uloge kaveolina-1 u kancerogenezi u zavisnosti od ćelijskog konteksta. BRAF V600E mutacija je detektovana gotovo isključivo u malignim lezijama, i utvrđeno je da kod papilarnog tiroidnog karcinoma pozitivno koreliše sa parametrima agresivnosti. Ova mutacija takođe pozitivno koreliše sa ekspresijom kaveolina-1 u epitelnom tkivnom odeljku, a negativno sa ekspresijom stromalnog kaveolina-1... Thyroid cancer is the most common malignancy of the endocrine system. Over the last 30 years the incidence of thyroid cancer has been increasing in almost all regions of the world, and this trend has also been recorded in Serbia. Fine Needle Aspiration Biopsy (FNAB) has enabled preoperative differential diagnosis of these lesions, however, 30% of aspirations yield indeterminate results. Patients with nodules that are not clearly benign or malignant undergo diagnostic lobectomy, and more that a third of them prove to have benign, indolent lesions that did not require surgical treatment. Patients diagnosed with malignancy, on the other hand, are referred to a second, therapeutic surgery. Postoperative diagnosis is more precise, yet, it has drawbacks. The criteria for differentiating benign from malignant lesions with follicular architecture is not well defined. The aforementioned obstacles stress the need for additional tests, i.e. the use of adjunct diagnostic biomarkers.A large number of potential protein and genetic biomarkers, as well as their combinations, has been analysed and some of them proved to have good diagnostic performances. Still, there are obstacles in applying these biomarkers in the clinical setting – immunohistochemical scoring of protein markers is prone to subjective interpretation, while genetic mutation testing, although high in specificity, shows low sensitivity given that many malignant lesions do not bear any known mutations.The aim of this dissertation was the evaluation of potential thyroid cancer biomarkers measured on DNA, RNA and protein level. Postoperative tissue samples were used for immunohistochemical analysis of the expression and tissue localisation of the protein caveolin-1, and determination of the presence of BRAF V600E mutation. Biopsy samples were used for the analysis of the previously mentioned biomarkers, as well as to determine the frequency of RET/PTC1 and 3 chromosomal rearrangements and EGFRvIII mutation. After dividing the samples in groups according to caveolin-1 expression and BRAF genotype, EGFR gene expression was measured. The mutual associations of these markers, components of the MAPK signaling pathway, were also determined. Markers with a good discriminatory power were analysed in combination. Their associations with clinico-pathological parameters were used to determine their prognostic value.The results of this dissertation have shown that protein expression of caveolin-1 can be used for differentiating lesions with similar histological features, as well for discriminating benign from malignant nodules. The levels of caveolin-1 in epithelial tissue compartment of malignant lesions correlate positively with the presence of lymphatic tumor spreading, while, contrary to that, stromal caveolin-1 correlates negatively with the degree of tumor infiltration. This indicates that caveolin-1 has different roles in cancer progression depending on the cellular context...

Published
2017

45. Analiza proteinskih i genetičkih biomarkera u preoperativnoj i postoperativnoj diferencijalnoj dijagnostici tumora štitaste žlezde

Author

Gavrović-Jankulović, Marija, Paskaš, Svetlana, Tatić, Svetislav, Nikolić, Milan, Janković, Jelena R., Gavrović-Jankulović, Marija, Paskaš, Svetlana, Tatić, Svetislav, Nikolić, Milan, and Janković, Jelena R.

Abstract

Karcinom štitne žlezde je najčešće maligno boljenje endokrinih organa. Incidenca tiroidnog kancera je u poslednih trideset godina porasla u gotovo svim regijama u svetu, i ovaj trend zabeležen je i u Srbiji. Citološka analiza uzoraka dobijenih biopsijom tankom iglom (FNAB) omogućava diferencijalnu dijagnostiku ovih lezija, međutim u oko 30% slučajeva daje neodređene rezultate. Pacijenti kojima se ne može postaviti jasna dijagnoza se šalju na dijagnostičku lobektomiju i kod više od trećine operisanih se dijagnostikuje indolentna benigna lezija koja nije zahtevala operativni tretman. Pacijenti sa malignitetom, sa druge strane, bivaju podvrgnuti i drugoj, terapeutskoj operaciji. Postoperativna dijagnostika, iako preciznija, takođe nije bez nedostataka. Kriterijumi koji razdvajaju benigne od malignih lezija folikularne arhitekture nisu jasno definisani. Ovi problemi ukazuju na potrebu za dodatnim testovima, odnosno pomoćnim dijagnostičkim markerima. Dosadašnje studije su analizirale različite proteinske i genetičke markere, kao i njihove kombinacije. Neki od njih su pokazali dobre dijagnostičke performanse. Ipak, različiti nedostaci prate upotrebu ovih markera u klinici - imunohistohemijsko određivanje proteinskih biomarkera podleže subjektivnosti u ocenjivanju, dok korišćenje mutacija kao genetičkih markera pokazuje visoku specifičnost, ali nisku osetljivost jer mnogi karcinomi ne nose mutacije. U ovoj disertaciji su analizirani biomarkeri mereni na nivou DNK, RNK i proteina. Na postoperativnim uzorcima je imunohistohemijski određena ekspresija i tkivna lokalizacija proteina kaveolina-1, kao i prisustvo BRAF V600E. U uzorcima biopsija je pored pomenutih markera, određeno i prisustvo RET/PTC1 i 3 hromozomskih rearanžmana i EGFRvIII mutacije. Ekspresija gena za EGFR je određena u uzorcima grupisanim prema ekspresiji kaveolina-1 i prisustva BRAF V600E mutacije, i analizirane su međusobne korelacije ovih markera, činilaca MAPK signalnog puta. Markeri koji su pokazali dobru, Thyroid cancer is the most common malignancy of the endocrine system. Over the last 30 years the incidence of thyroid cancer has been increasing in almost all regions of the world, and this trend has also been recorded in Serbia. Fine Needle Aspiration Biopsy (FNAB) has enabled preoperative differential diagnosis of these lesions, however, 30% of aspirations yield indeterminate results. Patients with nodules that are not clearly benign or malignant undergo diagnostic lobectomy, and more that a third of them prove to have benign, indolent lesions that did not require surgical treatment. Patients diagnosed with malignancy, on the other hand, are referred to a second, therapeutic surgery. Postoperative diagnosis is more precise, yet, it has drawbacks. The criteria for differentiating benign from malignant lesions with follicular architecture is not well defined. The aforementioned obstacles stress the need for additional tests, i.e. the use of adjunct diagnostic biomarkers. A large number of potential protein and genetic biomarkers, as well as their combinations, has been analysed and some of them proved to have good diagnostic performances. Still, there are obstacles in applying these biomarkers in the clinical setting – immunohistochemical scoring of protein markers is prone to subjective interpretation, while genetic mutation testing, although high in specificity, shows low sensitivity given that many malignant lesions do not bear any known mutations. The aim of this dissertation was the evaluation of potential thyroid cancer biomarkers measured on DNA, RNA and protein level. Postoperative tissue samples were used for immunohistochemical analysis of the expression and tissue localisation of the protein caveolin-1, and determination of the presence of BRAF V600E mutation. Biopsy samples were used for the analysis of the previously mentioned biomarkers, as well as to determine the frequency of RET/PTC1 and 3 chromosomal rearrangements and EGFRvIII mutation. After divi

Published
2017

46. Етимологија у часопису 'Наш језик'

Author

Milanović, Aleksandar, Loma, Aleksandar, Stanišić, Vanja, Janković, Jelena D., Milanović, Aleksandar, Loma, Aleksandar, Stanišić, Vanja, and Janković, Jelena D.

Abstract

Предмет дисертације су етимолошки подаци који се налазе у чланцима објављеним у лингвистичком часопису „Наш језик“ у временском распону од 1932/1933. до 2013. године. Међу његовим корицама су се, у складу с програмом часописа, нашли радови посвећени изучавању и нормирању српског (раније српско-хрватског) књижевног језика, решавању питања језичке културе, неговању те културе и усмеравању правца њеног даљег развитка. Иако је у „Нашем језику“ објављен мањи број етимолошких студија, часопис се показао као богат извор етимолошких података, а под тим подразумевамо сваку информацију која се тиче порекла, развоја и/или историје одређене речи, израза или синтаксичке конструкције..., The subject of this dissertation is the etymological information found in the papers published in the linguistic journal Naš jezik from 1932/1933 to 2013. In accordance with the journal program, the papers published in these volumes are dealing with topics such as study and standardization of the Serbian (formerly Serbo-Croatian) literary language; they are also addressing various language culture issues, fostering language culture as well as steering the direction of its further development. Even though only a smaller number of etymological studies have been published in the journal Naš jezik, it has proven to be a rich source of etymological information, and by that, we mean any information concerning origin, development, and/or history of a specific word, phrase or syntactic construction...

Published
2017

47. Surveillance Cinematography: An Analysis of Surveillance Discourse in Visual Culture

Author

Janković, Jelena, Hromadžić, Hajrudin, Pavlaković, Vjeran, and Peović Vuković, Katarina

Abstract

Veza nadzora i kinematografije duga je, kompleksna i usko isprepletena; politike nadzora pregovarane su na filmskom platnu od njegovih najranijih početaka. Imaju li se na umu različite prakse nadgledanja drugih s nekom svrhom, nadzor je zapravo star koliko i ljudska povijest.1 Oduvijek je prisutan na filmu i kroz film, ali u različitim formama i na različite načine. Proučavan kroz teorijski aparat psihoanalize i filmske teorije u obliku voajerizma, kroz Studije nadzora i sociološku prizmu teoretskih kretanja, kroz medijsku teoriju i manifestacije u domeni mreže i televizije, vrlo malo istraživanja nadzora seže dublje u teoriju od njegove prisutnosti u fabularnom toku filma. Sljedeći tekst bavi se upravo takozvanom kinematografijom nadzora te naracijom nadzora i nadzornom slikom kao njenim bitnim sastavnicama. Razlikuju se filmovi o nadzoru (»movies about surveillance«) i nadzorni narativi (»surveillance narratives«), no budući da se oni pretapaju i fluidni su u teoretskim razmatranjima, spominje se i hibridizacija nadzornog narativa. 2 Prvi se proučavaju u okviru žanrovske diferencijacije distopijskih predložaka i paranoidnih trilera, te figuracije dijegetske slike nadzora koju je moguće razlikovati od klasičnog narativnog tijeka, dok drugi utjelovljuju filmove koji inkorporiraju nadzornu retoriku iz razlitičitih ideoloških kuteva, što ovisi o mnogim društvenim, socio političkim, kulturalnim, povijesnim zavisnostima. Potonji pregovaraju s nadzorom kao instancom koja intervenira u samu strukturu filma, gdje se susreću nove paradigme, obrću subjektne pozicije, preispituju relacije subjekt/objekt, stvarno/fikcionalno, stvarno/viđeno, prostorno/temporalno, dijegetsko/ekstradijegetsko. Nadzorne slike tu figuriraju kao mutirana dimenzija koja zamagljuje ontološke razine gledanja, a posredovana je drugačijim politikama prikazivanja koje evoluiraju kroz film. Kao vrhunac nadzorne priče i njene reprezentacije na platnu uzet je digitalni ''Timecode'' Mikea Figgisa, na čijem semiotičkom i kinematografskom višku je najevidentnija proliferna instanca nadzornih praksi unutar kinematografije i njena semantička slojevitost.

Published
2016

48. Etička komponenta vođenja i njezin utjecaj na sigurnost poslovanja

Author

Janković, Jelena, Budimir Šoško, Gabrijela, and Ilijaš-Juranić, Barbara

Subjects
etika vodstva, sukob interesa, stakeholder teorija, sigurnost
Abstract

Utjecaj je bit vođenja, a snažni rukovoditelji mogu znatno djelovati na život podređenih i sudbinu organizacije. Primarno nije pitanje da li će rukovoditelji koristiti svoju moć, nego da li će ju koristiti na dobrobiti organizacije kojom rukovode ili radi svojih osobnih probitaka. Ako rukovoditelj prikazuje svoje neetične postupe legitimnima on može potaknuti svoje zaposlenike da učine zločin iz poslušnosti. Velika mogućnost zloupotrebe moći jedan je od glavnih razloga zašto su etičke komponente vođenja važne. Drugi je razlog pad povjerenja javnosti u korporativni sektor nakon niza skandala. Kako bi vođa mogao donositi etičke odluke razrađeni su modeli koje pritom upotrebljava. Razrada modela je učinjena na primjeru koji su razlozi doveli do svjetske financijske krize, sa tezom da se ista mogla spriječiti da su moralne vertikale odgovornih menadžera bile podešene na etički nedvojben način.

Published
2013

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