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354 results on '"Jang, Myoung-jin"'

7. Impact of HBeAg on Hepatocellular Carcinoma Risk During Oral Antiviral Treatment in Patients With Chronic Hepatitis B

Author

Jang, Heejoon, Yoon, Jun Sik, Park, Soo Young, Lee, Han Ah, Jang, Myoung-jin, Kim, Seung Up, Sinn, Dong Hyun, Seo, Yeon Seok, Kim, Hwi Young, Kim, Sung Eun, Jun, Dae Won, Yoon, Eileen L., Sohn, Joo Hyun, Ahn, Sang Bong, Shim, Jae-Jun, Jeong, Soung Won, Cho, Yong Kyun, Kim, Hyoung Su, Nam, Joon Yeul, Lee, Yun Bin, Kim, Yoon Jun, Yoon, Jung-Hwan, Zoulim, Fabien, Lampertico, Pietro, Dalekos, George N., Idilman, Ramazan, Sypsa, Vana, Berg, Thomas, Buti, Maria, Calleja, Jose Luis, Goulis, John, Manolakopoulos, Spilios, Janssen, Harry LA., Papatheodoridis, George V., and Lee, Jeong-Hoon

Published
2022
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8. Association Between Hypotension During Pancreatectomy and Development of Postoperative Diabetes.

Author

Moon, Seoil, Lee, Mirang, Lee, Jun Suh, Lee, Jooyeop, Oh, Tae Jung, Jang, Myoung-jin, Yoon, Yoo-Seok, Han, Youngmin, Kwon, Wooil, Jang, Jin-Young, and Jung, Hye Seung

Subjects
SYSTOLIC blood pressure, ISLANDS of Langerhans, INSULIN resistance, PANCREATIC secretions, PANCREATECTOMY
Abstract

Context With advancements in long-term survival after pancreatectomy, postpancreatectomy diabetes has become a concern, and the risk factors are not yet established. Pancreatic islets are susceptible to ischemic damage, though there is a lack of clinical evidence regarding glycemic deterioration. Objective To investigate association between hypotension during pancreatectomy and development of postpancreatectomy diabetes. Design In this retrospective, longitudinal cohort study, we enrolled patients without diabetes who underwent distal pancreatectomy or pancreaticoduodenectomy between January 2005 and December 2018 from 2 referral hospitals in Korea. Main outcome measures Intraoperative hypotension (IOH) was defined as a 20% or greater reduction in systolic blood pressure. The primary and secondary outcomes were incident diabetes and postoperative Homeostatic Model Assessment (HOMA) indices. Results We enrolled 1129 patients (average age, 59 years; 49% men; 35% distal pancreatectomy). IOH occurred in 83% (median duration, 25 minutes; interquartile range, 5-65). During a median follow-up of 3.9 years, diabetes developed in 284 patients (25%). The cumulative incidence of diabetes was proportional to increases in the duration and depth of IOH (P <.001). For the median duration in IOH compared with a reference time of 0 minutes, the hazard ratio was 1.48 (95% CI, 1.14-1.92). The effect of IOH was pronounced with distal pancreatectomy. Furthermore, the duration of IOH was inversely correlated with 1-year HOMA β-cell function (P <.002), but not with HOMA insulin resistance. Conclusion These results support the hypothesis that IOH during pancreatectomy may elevate risk of diabetes by inducing β-cell insufficiency. [ABSTRACT FROM AUTHOR]

Published
2025
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9. An artificial intelligence model to predict hepatocellular carcinoma risk in Korean and Caucasian patients with chronic hepatitis B

Author

Kim, Hwi Young, Lampertico, Pietro, Nam, Joon Yeul, Lee, Hyung-Chul, Kim, Seung Up, Sinn, Dong Hyun, Seo, Yeon Seok, Lee, Han Ah, Park, Soo Young, Lim, Young-Suk, Jang, Eun Sun, Yoon, Eileen L., Kim, Hyoung Su, Kim, Sung Eun, Ahn, Sang Bong, Shim, Jae-Jun, Jeong, Soung Won, Jung, Yong Jin, Sohn, Joo Hyun, Cho, Yong Kyun, Jun, Dae Won, Dalekos, George N., Idilman, Ramazan, Sypsa, Vana, Berg, Thomas, Buti, Maria, Calleja, Jose Luis, Goulis, John, Manolakopoulos, Spilios, Janssen, Harry L.A., Jang, Myoung-jin, Lee, Yun Bin, Kim, Yoon Jun, Yoon, Jung-Hwan, Papatheodoridis, George V., and Lee, Jeong-Hoon

Published
2022
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21. Changing patterns of multiple sclerosis in Korea: Toward a more baseline MRI lesions and intrathecal humoral immune responses

Author

Shin, Hyun-June, Hyun, Jae-Won, Kim, Su-Hyun, Park, Min Su, Sohn, Eun Hee, Baek, Seol-Hee, Kim, Byung-Jo, Choi, Kyomin, Oh, Jeeyoung, Cho, Joong-Yang, Kwon, Ohyun, Kim, Woojun, Kim, Jee-Eun, Min, Ju-Hong, Kim, Byoung Joon, Oh, Sun-Young, Bae, Jong Seok, Park, Kee Hong, Oh, Jung-Hwan, Sohn, Sung-Yeon, Jang, Myoung-Jin, Sung, Jung-Joon, Kim, Ho Jin, and Kim, Sung-Min

Published
2019
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23. Time to Treat First Acute Attack of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Author

Kwon, Young Nam, Kim, Boram, Kim, Jun-Soon, Park, Kyung Seok, Seo, Da-Young, Kim, Hyunjin, Lee, Eun-Jae, Lim, Young-Min, Ju, Hyunjin, Chung, Yeon Hak, Min, Ju-Hong, Nam, Tai-Seung, Kim, Sooyoung, Sohn, Eunhee, Shin, Kyong Jin, Seok, Jin Myoung, Kim, Sunyoung, Bae, Jong Seok, Lee, Sukyoon, Oh, Seong-il, Jung, Yu Jin, Park, Jinseok, Kim, Seung Hyun, Kim, Ki Hoon, Kim, Ho Jin, Jung, Jae Ho, Kim, Seong-Joon, Kim, Seung Woo, Jang, Myoung-jin, Sung, Jung-Joon, Waters, Patrick, Shin, Ha Young, and Kim, Sung-Min

Abstract

IMPORTANCE: A proportion of people with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) have a relapsing disease course and persistent anti–myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) seropositivity. Few studies have investigated whether treatment of the first MOGAD attack is associated with the long-term disease course and/or MOG-IgG seronegative conversion. OBJECTIVE: To investigate the association of time to treat the first acute MOGAD attack with relapse risk and MOG-IgG serostatus. DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective, nationwide, multicenter cohort study involving 14 secondary or tertiary hospitals in South Korea between November 2009 and August 2023. People with adult-onset MOGAD, who either had a relapse or were followed up for more than 12 months after disease onset and had a detailed medical record of their first attack, were included. Individuals were excluded for adolescent-onset MOGAD or short disease duration. EXPOSURES: Patients were categorized based on the time to treat the first acute MOGAD attack: early (&lt;5 days), intermediate (5-14 days), and late (not treated within 14 days). MAIN OUTCOMES AND MEASURES: A multivariable analysis for clinical and treatment factors associated with relapsing disease course and/or MOG-IgG seronegative conversion. Further subgroup analyses were conducted among those without long-term nonsteroidal immunosuppressant (NSIS) maintenance treatment. RESULTS: Among the 315 individuals screened, 75 were excluded. A total of 240 patients (median [IQR] age at onset, 40.4 [28.8-56.1] years; 125 female [52.1%]) with median (IQR) disease duration of 3.07 (1.95-6.15) years were included. A total of 110 of 240 patients (45.8%) relapsed after a median (IQR) of 0.45 (0.18-1.68) years, and 29 of 116 patients (25.0%) experienced a conversion to seronegative MOG-IgG. Both the time to treatment of the first MOGAD attack (late vs early: adjusted hazard ratio [aHR], 2.64; 95% CI, 1.43-4.84; P = .002; intermediate vs early: aHR, 2.02; 95% CI, 1.10-3.74; P = .02) and NSIS maintenance treatment (aHR, 0.24; 95% CI, 0.14-0.42; P &lt; .001) were independently associated with the risk of relapse. In a subgroup without NSIS maintenance, the time to treat of the first MOGAD attack was still associated with higher risk of relapse (late vs early: aHR, 3.51; 95% CI, 1.64-7.50; P = .001; intermediate vs early: aHR, 2.68; 95% CI, 1.23-5.85; P = .01). Lastly, the time to treat of the first MOGAD attack was also associated with MOG-IgG seronegative conversion (early vs late: adjusted odds ratio, 7.04; 95% CI, 1.58-31.41; P = .01), whereas NSIS maintenance treatment was not. CONCLUSIONS AND RELEVANCE: Results of this cohort study suggest that early treatment of the first acute MOGAD attack was associated with a reduction in the proportion of relapsing disease course and an increase in the likelihood of MOG-IgG seronegative conversion. These data suggest that timing of acute phase treatment for the first MOGAD attack can be associated with the long-term prognosis and autoimmune status of patients.

Published
2024
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24. Prognostic factors of first-onset optic neuritis based on diagnostic criteria and antibody status: a multicentre analysis of 427 eyes

Author

Min, Young Gi, primary, Moon, Yeji, additional, Kwon, Young Nam, additional, Lee, Byung Joo, additional, Park, Kyung-Ah, additional, Han, Jae Yong, additional, Han, Jinu, additional, Lee, Haeng-Jin, additional, Baek, Seol-Hee, additional, Kim, Byung-Jo, additional, Kim, Jun-Soon, additional, Park, Kyung Seok, additional, Kim, Nam-Hee, additional, Kim, Martha, additional, Nam, Tai-Seung, additional, Oh, Seong-Il, additional, Jung, Jae Ho, additional, Sung, Jung-Joon, additional, Jang, Myoung-Jin, additional, Kim, Seong-Joon, additional, and Kim, Sung-Min, additional

Published
2024
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35. Personalized Antiviral Drug Selection in Patients With Chronic Hepatitis B Using a Machine Learning Model: A Multinational Study

Author

Hur, Moon Haeng, primary, Park, Min Kyung, additional, Yip, Terry Cheuk-Fung, additional, Chen, Chien-Hung, additional, Lee, Hyung-Chul, additional, Choi, Won-Mook, additional, Kim, Seung Up, additional, Lim, Young-Suk, additional, Park, Soo Young, additional, Wong, Grace Lai-Hung, additional, Sinn, Dong Hyun, additional, Jin, Young-Joo, additional, Kim, Sung Eun, additional, Peng, Cheng-Yuan, additional, Shin, Hyun Phil, additional, Chen, Chi-Yi, additional, Kim, Hwi Young, additional, Lee, Han Ah, additional, Seo, Yeon Seok, additional, Jun, Dae Won, additional, Yoon, Eileen L., additional, Sohn, Joo Hyun, additional, Ahn, Sang Bong, additional, Shim, Jae-Jun, additional, Jeong, Soung Won, additional, Cho, Yong Kyun, additional, Kim, Hyoung Su, additional, Jang, Myoung-jin, additional, Kim, Yoon Jun, additional, Yoon, Jung-Hwan, additional, and Lee, Jeong-Hoon, additional

Published
2023
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