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4. Whole-genome bisulfite sequencing identifies stage- and subtype-specific DNA methylation signatures in pancreatic cancer

Author

Wang, Sarah S, Hall, Madison L, Lee, EunJung, Kim, Soon-Chan, Ramesh, Neha, Lee, Sang Hyub, Jang, Jin-Young, Bold, Richard J, Ku, Ja-Lok, and Hwang, Chang-Il

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Genetics, Cancer, Human Genome, Rare Diseases, Pancreatic Cancer, Digestive Diseases, 4.1 Discovery and preclinical testing of markers and technologies, 2.1 Biological and endogenous factors, Aetiology, Detection, screening and diagnosis, Epigenetics, cancer, cancer systems biology, genomics
Abstract

In pancreatic ductal adenocarcinoma (PDAC), no recurrent metastasis-specific mutation has been found, suggesting that epigenetic mechanisms, such as DNA methylation, are the major contributors of late-stage disease progression. Here, we performed the first whole-genome bisulfite sequencing (WGBS) on mouse and human PDAC organoid models to identify stage-specific and molecular subtype-specific DNA methylation signatures. With this approach, we identified thousands of differentially methylated regions (DMRs) that can distinguish between the stages and molecular subtypes of PDAC. Stage-specific DMRs are associated with genes related to nervous system development and cell-cell adhesions, and are enriched in promoters and bivalent enhancers. Subtype-specific DMRs showed hypermethylation of GATA6 foregut endoderm transcriptional networks in the squamous subtype and hypermethylation of EMT transcriptional networks in the progenitor subtype. These results indicate that aberrant DNA methylation contributes to both PDAC progression and subtype differentiation, resulting in significant and reoccurring DNA methylation patterns with diagnostic and prognostic potential.

Published
2024

5. The Value of Textbook Outcome in Benchmarking Pancreatoduodenectomy for Nonfunctioning Pancreatic Neuroendocrine Tumors

Author

Partelli, Stefano, Fermi, Francesca, Fusai, Giuseppe K., Tamburrino, Domenico, Lykoudis, Panagis, Beghdadi, Nassiba, Dokmak, Safi, Wiese, Dominik, Landoni, Luca, Reich, Federico, Busch, O. R. C., Napoli, Niccolò, Jang, Jin-Young, Kwon, Wooil, Armstrong, Thomas, Allen, Peter J., He, Jin, Javed, Ammar, Sauvanet, Alain, Bartsch, Detlef K., Salvia, Roberto, van Dijkum, E. J. M. Nieveen, Besselink, Mark G., Boggi, Ugo, Kim, Sun-Whe, Wolfgang, Christofer L., and Falconi, Massimo

Published
2024
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8. Adenomyomas of the Gallbladder: An Analysis of Frequency, Clinicopathologic Associations, and Relationship to Carcinoma of a Malformative Lesion

Author

Dursun, Nevra, Memis, Bahar, Pehlivanoglu, Burcin, Taskin, Orhun Cig, Okcu, Oguzhan, Akkas, Gizem, Bagci, Pelin, Balci, Serdar, Saka, Burcu, Araya, Juan Carlos, Bellolio, Enrique, Roa, Juan Carlos, Jang, Kee-Taek, Losada, Hector, Maithel, Shishir K., Sarmiento, Juan, Reid, Michelle D., Jang, Jin- Young, Cheng, Jeanette D., Basturk, Olca, Koshiol, Jill, and Adsay, N. Volkan

Subjects
Carcinoma -- Analysis, Cancer -- Analysis, Health
Abstract

* Context.--The nature and associations of gallbladder (GB) 'adenomyoma' (AM) remain controversial. Some studies have attributed up to 26% of GB carcinoma to AMs. Objective.--To examine the true frequency, clinicopathologic characteristics, and neoplastic changes in GB AM. Design.--Cholecystectomy cohorts analyzed were 1953 consecutive cases, prospectively with specific attention to AM; 2347 consecutive archival cases; 203 totally embedded GBs; 207 GBs with carcinoma; and archival search of institutions for all cases diagnosed as AM. Results.--Frequency of AM was 9.3% (19 of 203) in totally submitted cases but 3.3% (77 of 2347) in routinely sampled archival tissue. A total of 283 AMs were identified, with a female to male ratio = 1.9 (177:94) and mean size = 1.3 cm (range, 0.3-5.9). Most (96%, 203 of 210) were fundic, with formed nodular trabeculated submucosal thickening, and were difficult to appreciate from the mucosal surface. Four of 257 were multifocal (1.6%), and 3 of 257 (1.2%) were extensive ('adenomyomatosis'). Dilated glands (up to 14 mm), often radially converging to a point in the mucosa, were typical. Muscle was often minimal, confined to the upper segment. Nine of 225 (4%) revealed features of a duplication. No specific associations with inflammation, cholesterolosis, intestinal metaplasia, or thickening of the uninvolved GB wall were identified. Neoplastic change arising in AM was seen in 9.9% (28 of 283). Sixteen of 283 (5.6%) had mural intracholecystic neoplasm; 7 of 283 (2.5%) had flat-type high-grade dysplasia/carcinoma in situ. Thirteen of 283 cases had both AM and invasive carcinoma (4.6%), but in only 5 of 283 (1.8%), carcinoma arose from AM (invasion was confined to AM, and dysplasia was predominantly in AM). Conclusions.--AMs have all the features of a malformative developmental lesion, and may not show a significant muscle component (ie, the name 'adeno-myoma' is partly a misnomer). While most are innocuous, some pathologies may arise in AMs, including intracholecystic neoplasms, flat-type high-grade dysplasia or carcinoma in situ, and invasive carcinoma (1.8%, 5 of 283). It is recommended that gross examination of GBs include serial slicing of the fundus for AM detection and total submission if one is found. (Arch Pathol Lab Med. 2024;148:206-214; doi: 10.5858/arpa.2022-0379-OA), Adenomyoma (AM), also called 'adenomyomatous hyperplasia' or ' adenomyomatous nodule,' has been noted as an often asymptomatic incidental lesion in cholecystectomies. (1,2) It is described as a collection of glands [...]

Published
2024
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10. ASO Visual Abstract: The Value of Textbook Outcome in Benchmarking Pancreatoduodenectomy for Nonfunctioning Pancreatic Neuroendocrine Tumors

Author

Partelli, Stefano, Fermi, Francesca, Fusai, Giuseppe K., Tamburrino, Domenico, Lykoudis, Panagis, Beghdadi, Nassiba, Dokmak, Safi, Wiese, Dominik, Landoni, Luca, Reich, Federico, Busch, O. R. C., Napoli, Niccolò, Jang, Jin-Young, Kwon, Wooil, Armstrong, Thomas, Allen, Peter J., He, Jin, Javed, Ammar, Sauvanet, Alain, Bartsch, Detlef K., Salvia, Roberto, van Dijkum, E. J. M. Nieveen, Besselink, M. G., Boggi, Ugo, Kim, Sun-Whe, Wolfgang, Christofer L., and Falconi, Massimo

Published
2024
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13. ‘IHPBA-APHPBA clinical practice guidelines’: international Delphi consensus recommendations for gallbladder cancer

Author

Palepu, Jagannath, Endo, Itaru, Chaudhari, Vikram Anil, Murthy, G.V.S., Chaudhuri, Sirshendu, Adam, Rene, Smith, Martin, de Reuver, Philip R., Lendoire, Javier, Shrikhande, Shailesh V., De Aretxabala, Xabier, Sirohi, Bhawna, Kokudo, Norihiro, Kwon, Wooil, Pal, Sujoy, Bouzid, Chafik, Dixon, Elijah, Shah, Sudeep Rohit, Maroni, Rodrigo, Nervi, Bruno, Mengoa, Claudio, Patil, Shekhar, Ebata, Tomoki, Maithel, Shishir K., Lang, Hauke, Primrose, John, Hirano, Satoshi, Guevara, Oscar A., Ohtsuka, Masayuki, Valle, Juan W., Sharma, Atul, Nagarajan, Ganesh, Núñez Ju, Juan Jose, Arroyo, Gerardo Francisco, Torrez, Sergio Lopez, Erdmann, Joris Ivo, Butte, Jean M., Furuse, Junji, Lee, Seung Eun, Gomes, António Pedro, Park, Sang-Jae, Jang, Jin-Young, Oddi, Ricardo, Barreto, Savio George, Kijima, Hiroshi, Ciacio, Oriana, Gowda, Nagesh S., and Jarnagin, William

Published
2024
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18. Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma

Author

Koh, Youngil, Kim, Hyemin, Joo, So Young, Song, Seulki, Choi, Young Hoon, Kim, Hyung Rae, Moon, Byul, Byun, Jamin, Hong, Junshik, Shin, Dong-Yeop, Park, Solip, Lee, Kwang Hyuck, Lee, Kyu Taek, Lee, Jong Kyun, Park, Daechan, Lee, Se-Hoon, Jang, Jin-Young, Lee, Hyunsook, Kim, Jung-Ae, Yoon, Sung-Soo, and Park, Joo Kyung

Published
2023
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19. The clinical implication of minimally invasive versus open pancreatoduodenectomy for non-pancreatic periampullary cancer: a systematic review and individual patient data meta-analysis

Author

Uijterwijk, Bas A., Kasai, Meidai, Lemmers, Daniel H. L., Chinnusamy, Palanivelu, van Hilst, Jony, Ielpo, Benedetto, Wei, Kongyuan, Song, Ki Byung, Kim, Song C., Klompmaker, Sjors, Jang, Jin-Young, Herremans, Kelly M., Bencini, Lapo, Coratti, Andrea, Mazzola, Michele, Menon, Krishna V., Goh, Brian K. P., Qin, Renyi, Besselink, Marc G., and Abu Hilal, Mohammed

Published
2023
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26. Impact of patient age on outcome of minimally invasive versus open pancreatoduodenectomy: a propensity score matched study

Author

Emmen, Anouk M.L.H., Jones, Leia R., Wei, Kongyuan, Busch, Olivier, Shen, Baiyong, Fusai, Giuseppe K., Shyr, Yi-Ming, Khatkov, Igor, White, Steve, Boggi, Ugo, Kerem, Mustafa, Molenaar, I.Q., Koerkamp, Bas G., Saint-Marc, Olivier, Dokmak, Safi, van Dieren, Susan, Rozzini, Renzo, Festen, Sebastiaan, Liu, Rong, Jang, Jin-Young, Besselink, Marc G., and Hilal, Mohammed A.

Published
2024
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27. International survey on opinions and use of robot-assisted and laparoscopic minimally invasive pancreatic surgery: 5-year follow up

Author

van Ramshorst, Tess M.E., van Hilst, Jony, Bannone, Elisa, Pulvirenti, Alessandra, Asbun, Horacio J., Boggi, Ugo, Busch, Olivier R., Dokmak, Safi, Edwin, Bjørn, Hogg, Melissa, Jang, Jin-Young, Keck, Tobias, Khatkov, Igor, Kohan, Gustavo, Kokudo, Norihiro, Kooby, David A., Nakamura, Masafumi, Primrose, John N., Siriwardena, Ajith K., Toso, Christian, Vollmer, Charles M., Zeh, Herbert J., Besselink, Marc G., and Abu Hilal, Mohammad

Published
2024
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29. Robot-Assisted Versus Laparoscopic Distal Pancreatectomy in Patients with Resectable Pancreatic Cancer: An International, Retrospective, Cohort Study

Author

Chen, Jeffrey W., van Ramshorst, Tess M. E., Lof, Sanne, Al-Sarireh, Bilal, Bjornsson, Bergthor, Boggi, Ugo, Burdio, Fernando, Butturini, Giovanni, Casadei, Riccardo, Coratti, Andrea, D’Hondt, Mathieu, Dokmak, Safi, Edwin, Bjørn, Esposito, Alessandro, Fabre, Jean M., Ferrari, Giovanni, Ftériche, Fadhel S., Fusai, Giuseppe K., Groot Koerkamp, Bas, Hackert, Thilo, Jah, Asif, Jang, Jin-Young, Kauffmann, Emanuele F., Keck, Tobias, Manzoni, Alberto, Marino, Marco V., Molenaar, Quintus, Pando, Elizabeth, Pessaux, Patrick, Pietrabissa, Andrea, Soonawalla, Zahir, Sutcliffe, Robert P., Timmermann, Lea, White, Steven, Yip, Vincent S., Zerbi, Alessandro, Abu Hilal, Mohammad, and Besselink, Marc G.

Published
2023
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30. FOLFIRINOX or Gemcitabine-based Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Cancer: A Multi-institutional, Patient-Level, Meta-analysis and Systematic Review

Author

Eshmuminov, Dilmurodjon, Aminjonov, Botirjon, Palm, Russell F., Malleo, Giuseppe, Schmocker, Ryan K., Abdallah, Raëf, Yoo, Changhoon, Shaib, Walid L., Schneider, Marcel André, Rangelova, Elena, Choi, Yoo Jin, Kim, Hongbeom, Rose, J. Bart, Patel, Sameer, Wilson, Gregory C., Maloney, Sarah, Timmermann, Lea, Sahora, Klaus, Rössler, Fabian, Lopez-Lopez, Víctor, Boyer, Emanuel, Maggino, Laura, Malinka, Thomas, Park, Jeong Youp, Katz, Matthew H. G., Prakash, Laura, Ahmad, Syed A., Helton, Scott, Jang, Jin-Young, Hoffe, Sarah E., Salvia, Roberto, Taieb, Julien, He, Jin, Clavien, Pierre-Alain, Held, Ulrike, and Lehmann, Kuno

Published
2023
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32. The Brescia Internationally Validated European Guidelines on Minimally Invasive Pancreatic Surgery (EGUMIPS)

Author

Abu Hilal, Mohammad, van Ramshorst, Tess M.E., Boggi, Ugo, Dokmak, Safi, Edwin, Bjørn, Keck, Tobias, Khatkov, Igor, Ahmad, Jawad, Al Saati, Hani, Alseidi, Adnan, Azagra, Juan S., Björnsson, Bergthor, Can, Fatih M., D’Hondt, Mathieu, Efanov, Mikhail, Espin Alvarez, Francisco, Esposito, Alessandro, Ferrari, Giovanni, Groot Koerkamp, Bas, Gumbs, Andrew A., Hogg, Melissa E., Huscher, Cristiano G.S., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin-Young, Liu, Rong, Luyer, Misha D.P., Menon, Krishna, Nakamura, Masafumi, Piardi, Tullio, Saint-Marc, Olivier, White, Steve, Yoon, Yoo-Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C.P., Cook, Andrew, Dervenis, Christos, Falconi, Massimo, Ferrari, Clarissa, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Badran, Ali, Baychorov, Magomet, Bannone, Elisa, van Bodegraven, Eduard A., Emmen, Anouk M.L.H., Giani, Alessandro, de Graaf, Nine, van Hilst, Jony, Jones, Leia R., Levi Sandri, Giovanni B., Pulvirenti, Alessandra, Ramera, Marco, Rashidian, Niki, Sahakyan, Mushegh A., Uijterwijk, Bas A., Zampedri, Pietro, Zwart, Maurice J.W., Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Di Benedetto, Fabrizio, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Portolani, Nazario, Ruzzenente, Andrea, Salvia, Roberto, Siriwardena, Ajith K., Besselink, Marc G., Asbun, Horacio J., Over, Paul, Saleh, Omar, and Rivizzigno, Piero

Published
2024
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33. Surveillance for Presumed BD-IPMN of the Pancreas: Stability, Size, and Age Identify Targets for Discontinuation

Author

Marchegiani, Giovanni, Pollini, Tommaso, Burelli, Anna, Han, Youngmin, Jung, Hye-Sol, Kwon, Wooil, Rocha Castellanos, Dario Missael, Crippa, Stefano, Belfiori, Giulio, Arcidiacono, Paolo Giorgio, Capurso, Gabriele, Apadula, Laura, Zaccari, Piera, Noia, José Lariño, Gorris, Myrte, Busch, Olivier, Ponweera, Arachchige, Mann, Kulbir, Demir, Ihsan Ekin, Phillip, Veit, Ahmad, Nuzhat, Hackert, Thilo, Heckler, Max, Lennon, Anne Marie, Afghani, Elham, Vallicella, Davide, Dall’Olio, Tommaso, Nepi, Angelica, Vollmer, Charles M., Friess, Helmut, Ghaneh, Paula, Besselink, Marc, Falconi, Massimo, Bassi, Claudio, Goh, Brian Kim-Poh, Jang, Jin-Young, Fernández-Del Castillo, Carlos, and Salvia, Roberto

Published
2023
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36. Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population reveals tumor cell-enriched and immune-rich subtypes

Author

Hyeon, Do Young, Nam, Dowoon, Han, Youngmin, Kim, Duk Ki, Kim, Gibeom, Kim, Daeun, Bae, Jingi, Back, Seunghoon, Mun, Dong-Gi, Madar, Inamul Hasan, Lee, Hangyeore, Kim, Su-Jin, Kim, Hokeun, Hyun, Sangyeop, Kim, Chang Rok, Choi, Seon Ah, Kim, Yong Ryoul, Jeong, Juhee, Jeon, Suwan, Choo, Yeon Woong, Lee, Kyung Bun, Kwon, Wooil, Choi, Seunghyuk, Goo, Taewan, Park, Taesung, Suh, Young-Ah, Kim, Hongbeom, Ku, Ja-Lok, Kim, Min-Sik, Paek, Eunok, Park, Daechan, Jung, Keehoon, Baek, Sung Hee, Jang, Jin-Young, Hwang, Daehee, and Lee, Sang-Won

Published
2023
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37. ASO Visual Abstract: Robot-Assisted Versus Laparoscopic Distal Pancreatectomy in Patients with Resectable Pancreatic Cancer—An International Retrospective Cohort Study

Author

Chen, Jeffrey W., van Ramshorst, Tess M. E., Lof, Sanne, Al-Sarireh, Bilal, Bjornsson, Bergthor, Boggi, Ugo, Burdio, Fernando, Butturini, Giovanni, Casadei, Riccardo, Coratti, Andrea, D’Hondt, Mathieu, Dokmak, Safi, Edwin, Bjørn, Esposito, Alessandro, Fabre, Jean M., Ferrari, Giovanni, Ftériche, Fadhel S., Fusai, Giuseppe K., Koerkamp, Bas Groot, Hackert, Thilo, Jah, Asif, Jang, Jin-Young, Kauffmann, Emanuele F., Keck, Tobias, Manzoni, Alberto, Marino, Marco V., Molenaar, Quintus, Rau, Elizabeth Pando, Pessaux, Patrick, Pietrabissa, Andrea, Soonawalla, Zahir, Sutcliffe, Robert P., Timmermann, Lea, White, Steven, Yip, Vincent S., Zerbi, Alessandro, Hilal, Mohammad Abu, and Besselink, Marc G.

Published
2023
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38. The PD-ROBOSCORE: A difficulty score for robotic pancreatoduodenectomy

Author

Napoli, Niccolò, Cacace, Concetta, Kauffmann, Emanuele F., Jones, Leia, Ginesini, Michael, Gianfaldoni, Cesare, Salamone, Alice, Asta, Fabio, Ripolli, Allegra, Di Dato, Armando, Busch, Olivier R., Cappelle, Marie L., Chao, Ying Jui, de Wilde, Roeland F., Hackert, Thilo, Jang, Jin-Young, Koerkamp, Bas Groot, Kwon, Wooil, Lips, Daan, Luyer, Misha D.P., Nickel, Felix, Saint-Marc, Olivier, Shan, Yan-Shen, Shen, Baiyong, Vistoli, Fabio, Besselink, Marc G., Hilal, Mohammad Abu, and Boggi, Ugo

Published
2023
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41. Is surgical resection justified for pancreatic ductal adenocarcinoma with distant abdominal organ metastasis? A position paper by experts in pancreatic surgery at the Joint Meeting of the International Association of Pancreatology (IAP) & the Japan Pancreas Society (JPS) 2022 in Kyoto

Author

Hashimoto, Daisuke, Satoi, Sohei, Fujii, Tsutomu, Sho, Masayuki, He, Jin, Hackert, Thilo, Del Chiaro, Marco, Jang, Jin-Young, Gulla, Aiste, Yoon, Yoo-Seok, Shan, Yan-Shen, Lou, Wenhui, Valente, Roberto, Furuse, Junji, Oba, Atsushi, Nagai, Minako, Terai, Taichi, Tanaka, Haruyoshi, Sakai, Ayano, Yamamoto, Tomohisa, Yamaki, So, Matsumoto, Ippei, Murakami, Yoshiaki, Takaori, Kyoichi, and Takeyama, Yoshifumi

Published
2023
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42. “Conversion surgery” for locally advanced pancreatic cancer: A position paper by the study group at the joint meeting of the International Association of Pancreatology (IAP) & Japan Pancreas Society (JPS) 2022

Author

Oba, Atsushi, Del Chiaro, Marco, Fujii, Tsutomu, Okano, Keiichi, Stoop, Thomas F., Wu, Y.H. Andrew, Maekawa, Aya, Yoshida, Yuta, Hashimoto, Daisuke, Sugawara, Toshitaka, Inoue, Yosuke, Tanabe, Minoru, Sho, Masayuki, Sasaki, Takashi, Takahashi, Yu, Matsumoto, Ippei, Sasahira, Naoki, Nagakawa, Yuichi, Satoi, Sohei, Schulick, Richard D., Yoon, Yoo-Seok, He, Jin, Jang, Jin-Young, Wolfgang, Christopher L., Hackert, Thilo, Besselink, Marc G., Takaori, Kyoichi, and Takeyama, Yoshifumi

Published
2023
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47. ASO Visual Abstract: FOLFIRINOX or Gemcitabine Based Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Cancer: A Multi-Institutional, Patient-Level Meta-Analysis and Systematic Review

Author

Eshmuminov, Dilmurodjon, Aminjonov, Botirjon, Palm, Russell F., Malleo, Giuseppe, Schmocker, Ryan K., Abdallah, Raëf, Yoo, Changhoon, Shaib, Walid L., Schneider, Marcel André, Rangelova, Elena, Choi, Yoo Jin, Kim, Hongbeom, Rose, J. Bart, Patel, Sameer, Wilson, Gregory C., Maloney, Sarah, Timmermann, Lea, Sahora, Klaus, Rössler, Fabian, Lopez-Lopez, Víctor, Boyer, Emanuel, Maggino, Laura, Malinka, Thomas, Park, Jeong Youp, Katz, Matthew H. G., Prakash, Laura, Ahmad, Syed A., Helton, Scott, Jang, Jin-Young, Hoffe, Sarah E., Salvia, Roberto, Taieb, Julien, He, Jin, Clavien, Pierre-Alain, Held, Ulrike, and Lehmann, Kuno

Published
2023
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48. Comparison of oncologic outcomes between open and laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma using data from the KOTUS-BP national database: overcoming selection bias and the necessity of definite indications

Author

Kim, Hongbeom, Heo, Jin Seok, Kang, Chang Moo, Hwang, Ho Kyoung, Han, Ho-Seong, Yoon, Yoo-Seok, Park, Joon Seong, Han, Sung-Sik, Kim, Yong Hoon, Lee, Hyeon Kook, Yu, Young-Dong, Choi, In Seok, Yang, Jae Do, Roh, Younghoon, Kim, Seong-Ryong, Chung, Junchul, Song, Sang Hwa, Kim, Song Cheol, and Jang, Jin-Young

Published
2022
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49. Management Algorithms for Pancreatic Cystic Neoplasms: The Surgeon's Perspective

Author

Kim, Hyeong Seok and Jang, Jin-Young

Subjects
Pancreatic tumors -- Care and treatment -- Diagnosis, Practice guidelines (Medicine), Cysts -- Care and treatment -- Diagnosis, Algorithms -- Usage, Algorithm, Health
Abstract

Context.--The detection of pancreatic cystic neoplasms (PCNs) has increased owing to the advancement and widespread use of imaging modalities, resulting in differences between past and current management methods for PCNs, including intraductal papillary mucinous neoplasms (IPMNs). Therefore, clinicians should accurately diagnose and determine appropriate treatment strategies. However, previously published treatment guidelines for IPMNs present different indications for treatment. Objective.--To review the current status of PCNs, including epidemiologic change, malignancy risk, and factors for treatment, and to provide the optimal management algorithms for PCNs, including IPMNs, from the clinician's point of view. Data Sources.--Literature review of published studies and the authors' own work. Conclusions.--The treatment of PCNs relies on the type of cyst that is present or suspected. Serous cystic neoplasms are usually benign, and observation is sufficient. However, surgical treatment is required for mucinous cystic neoplasms, and malignancy risk differs according to lesion size. Solid pseudopapillary neoplasms also require surgery. The detection of small IPMNs has been increasing, and most branch duct-type IPMNs are dormant. However, cysts 3 cm or larger or growing branch duct-type IPMNs must be carefully monitored because of the increasing risk of malignancy. Therefore, surveillance strategies should be different according to the size of the lesions. A tailored approach is needed for selecting surgery or surveillance, considering the malignancy potential of the lesion and patient-associated factors such as operative risks and life expectancy. Nomograms are valuable tools for selecting treatment methods as a customized approach for IPMNs. (Arch Pathol Lab Med. 2022;146:322-329; doi: 10.5858/arpa.2020-0395-RA), The incidence of pancreatic cystic neoplasms (PCNs) has been increasing owing to the advancements in imaging technologies and the widespread use of cross-sectional imaging such as computed tomography and magnetic [...]

Published
2022
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