1. Characterization of the anterior segment in Trisomy 21-associated cataract using ultrasound biomicroscopy
- Author
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Dhruv M. Shah, Esther M. Xu, Radhika S. Gholap, Zahur F. Sallman, Taylor Kolosky, Moran R. Levin, Sudhir Vashist, and Janet L. Alexander
- Subjects
Cataracts ,Trisomy 21 ,Ultrasound ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Backgroundobjectives: To compare the structural anatomy of the anterior segment in pediatric Trisomy 21 (T21) subjects with and without cataracts to age-matched controls. Design: Prospective case-control study. Participants: 40 subjects (57 eyes) age 0–25 years old (9.1 ± 10.6 years). Methods: This prospective case-control study evaluated anterior segment measurements from ultrasound biomicroscopy (UBM) imaging on 342 images. Results: Among persons with T21 cataract, the iris was significantly thinner than T21 individuals without cataract (0.28 vs 0.32 mm, p = 0.0181). T21/cataract subjects also had significantly thinner lenses than subjects without cataract, regardless of whether they have T21 or are controls (3.1 mm vs 3.5 mm, p = 0.0074).Thinner lens (
- Published
- 2024
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