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1. The Influence of Electron Beam Sterilization on In Vivo Degradation of β-TCP/PCL of Different Composite Ratios for Bone Tissue Engineering

Author

Jin-Ho Kang, Janelle Kaneda, Jae-Gon Jang, Kumaresan Sakthiabirami, Elaine Lui, Carolyn Kim, Aijun Wang, Sang-Won Park, and Yunzhi Peter Yang

Subjects
3d printing, β-tricalcium phosphate/polycaprolactone (β-tcp/pcl) composite, bone tissue engineering, electron beam sterilization, Mechanical engineering and machinery, TJ1-1570
Abstract

We evaluated the effect of electron beam (E-beam) sterilization (25 kGy, ISO 11137) on the degradation of β-tricalcium phosphate/polycaprolactone (β-TCP/PCL) composite filaments of various ratios (0:100, 20:80, 40:60, and 60:40 TCP:PCL by mass) in a rat subcutaneous model for 24 weeks. Volumes of the samples before implantation and after explantation were measured using micro-computed tomography (micro-CT). The filament volume changes before sacrifice were also measured using a live micro-CT. In our micro-CT analyses, there was no significant difference in volume change between the E-beam treated groups and non-E-beam treated groups of the same β-TCP to PCL ratios, except for the 0% β-TCP group. However, the average volume reduction differences between the E-beam and non-E-beam groups in the same-ratio samples were 0.76% (0% TCP), 3.30% (20% TCP), 4.65% (40% TCP), and 3.67% (60% TCP). The E-beam samples generally had more volume reduction in all experimental groups. Therefore, E-beam treatment may accelerate degradation. In our live micro-CT analyses, most volume reduction arose in the first four weeks after implantation and slowed between 4 and 20 weeks in all groups. E-beam groups showed greater volume reduction at every time point, which is consistent with the results by micro-CT analysis. Histology results suggest the biocompatibility of TCP/PCL composite filaments.

Published
2020
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2. The Influence of Electron Beam Sterilization on In Vivo Degradation of β-TCP/PCL of Different Composite Ratios for Bone Tissue Engineering

Author

Yunzhi Peter Yang, Jae Gon Jang, Kumaresan Sakthiabirami, Aijun Wang, Sang-Won Park, Elaine Lui, Janelle Kaneda, Carolyn Kim, and Jin-Ho Kang

Subjects
Biocompatibility, In vivo degradation, lcsh:Mechanical engineering and machinery, 0206 medical engineering, Composite number, PCL) composite, Bioengineering, 02 engineering and technology, Article, Bone tissue engineering, chemistry.chemical_compound, β-tricalcium phosphate/polycaprolactone (β-TCP/PCL) composite, Electron beam processing, Nanotechnology, electron beam sterilization, lcsh:TJ1-1570, Electrical and Electronic Engineering, bone tissue engineering, Chemistry, Mechanical Engineering, Histology, 3D printing, Sterilization (microbiology), 021001 nanoscience & nanotechnology, 020601 biomedical engineering, Control and Systems Engineering, Polycaprolactone, Biomedical Imaging, polycaprolactone (beta-TCP, 0210 nano-technology, beta-tricalcium phosphate, Biomedical engineering
Abstract

We evaluated the effect of electron beam (E-beam) sterilization (25 kGy, ISO 11137) on the degradation of &beta, tricalcium phosphate/polycaprolactone (&beta, TCP/PCL) composite filaments of various ratios (0:100, 20:80, 40:60, and 60:40 TCP:PCL by mass) in a rat subcutaneous model for 24 weeks. Volumes of the samples before implantation and after explantation were measured using micro-computed tomography (micro-CT). The filament volume changes before sacrifice were also measured using a live micro-CT. In our micro-CT analyses, there was no significant difference in volume change between the E-beam treated groups and non-E-beam treated groups of the same &beta, TCP to PCL ratios, except for the 0% &beta, TCP group. However, the average volume reduction differences between the E-beam and non-E-beam groups in the same-ratio samples were 0.76% (0% TCP), 3.30% (20% TCP), 4.65% (40% TCP), and 3.67% (60% TCP). The E-beam samples generally had more volume reduction in all experimental groups. Therefore, E-beam treatment may accelerate degradation. In our live micro-CT analyses, most volume reduction arose in the first four weeks after implantation and slowed between 4 and 20 weeks in all groups. E-beam groups showed greater volume reduction at every time point, which is consistent with the results by micro-CT analysis. Histology results suggest the biocompatibility of TCP/PCL composite filaments.

Published
2020
Full Text
View/download PDF

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