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14 results on '"Janefeldt, Annika"'

2. Supplementary Data from Preclinical Comparison of the Blood–brain barrier Permeability of Osimertinib with Other EGFR TKIs

Author

Colclough, Nicola, primary, Chen, Kan, primary, Johnström, Peter, primary, Strittmatter, Nicole, primary, Yan, Yumei, primary, Wrigley, Gail L., primary, Schou, Magnus, primary, Goodwin, Richard, primary, Varnäs, Katarina, primary, Adua, Sally J., primary, Zhao, Minghui, primary, Nguyen, Don X., primary, Maglennon, Gareth, primary, Barton, Peter, primary, Atkinson, James, primary, Zhang, Lin, primary, Janefeldt, Annika, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Takano, Akihiro, primary, Arakawa, Ryosuke, primary, Kondrashov, Mikhail, primary, Malmquist, Jonas, primary, Revunov, Evgeny, primary, Vazquez-Romero, Ana, primary, Moein, Mohammad Mahdi, primary, Windhorst, Albert D., primary, Karp, Natasha A., primary, Finlay, M. Raymond V., primary, Ward, Richard A., primary, Yates, James W.T., primary, Smith, Paul D., primary, Farde, Lars, primary, Cheng, Zack, primary, and Cross, Darren A.E., primary

Published
2023
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3. Figure S1 from Preclinical Comparison of the Blood–brain barrier Permeability of Osimertinib with Other EGFR TKIs

Author

Colclough, Nicola, primary, Chen, Kan, primary, Johnström, Peter, primary, Strittmatter, Nicole, primary, Yan, Yumei, primary, Wrigley, Gail L., primary, Schou, Magnus, primary, Goodwin, Richard, primary, Varnäs, Katarina, primary, Adua, Sally J., primary, Zhao, Minghui, primary, Nguyen, Don X., primary, Maglennon, Gareth, primary, Barton, Peter, primary, Atkinson, James, primary, Zhang, Lin, primary, Janefeldt, Annika, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Takano, Akihiro, primary, Arakawa, Ryosuke, primary, Kondrashov, Mikhail, primary, Malmquist, Jonas, primary, Revunov, Evgeny, primary, Vazquez-Romero, Ana, primary, Moein, Mohammad Mahdi, primary, Windhorst, Albert D., primary, Karp, Natasha A., primary, Finlay, M. Raymond V., primary, Ward, Richard A., primary, Yates, James W.T., primary, Smith, Paul D., primary, Farde, Lars, primary, Cheng, Zack, primary, and Cross, Darren A.E., primary

Published
2023
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4. The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

Author

Prill, Sebastian, Caddeo, Andrea, Baselli, Guido, Jamialahmadi, Oveis, Dongiovanni, Paola, Rametta, Raffaela, Kanebratt, Kajsa P., Pujia, Arturo, Pingitore, Piero, Mancina, Rosellina Margherita, Lindén, Daniel, Whatling, Carl, Janefeldt, Annika, Kozyra, Mikael, Ingelman-Sundberg, Magnus, Valenti, Luca, Andersson, Tommy B., and Romeo, Stefano

Published
2019
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6. Preclinical Comparison of the Blood–brain barrier Permeability of Osimertinib with Other EGFR TKIs

Author

Colclough, Nicola, primary, Chen, Kan, additional, Johnström, Peter, additional, Strittmatter, Nicole, additional, Yan, Yumei, additional, Wrigley, Gail L., additional, Schou, Magnus, additional, Goodwin, Richard, additional, Varnäs, Katarina, additional, Adua, Sally J., additional, Zhao, Minghui, additional, Nguyen, Don X., additional, Maglennon, Gareth, additional, Barton, Peter, additional, Atkinson, James, additional, Zhang, Lin, additional, Janefeldt, Annika, additional, Wilson, Joanne, additional, Smith, Aaron, additional, Takano, Akihiro, additional, Arakawa, Ryosuke, additional, Kondrashov, Mikhail, additional, Malmquist, Jonas, additional, Revunov, Evgeny, additional, Vazquez-Romero, Ana, additional, Moein, Mohammad Mahdi, additional, Windhorst, Albert D., additional, Karp, Natasha A., additional, Finlay, M. Raymond V., additional, Ward, Richard A., additional, Yates, James W.T., additional, Smith, Paul D., additional, Farde, Lars, additional, Cheng, Zack, additional, and Cross, Darren A.E., additional

Published
2021
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8. The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

Author

Durant, Stephen T., primary, Zheng, Li, additional, Wang, Yingchun, additional, Chen, Kan, additional, Zhang, Lingli, additional, Zhang, Tianwei, additional, Yang, Zhenfan, additional, Riches, Lucy, additional, Trinidad, Antonio G., additional, Fok, Jacqueline H. L., additional, Hunt, Tom, additional, Pike, Kurt G., additional, Wilson, Joanne, additional, Smith, Aaron, additional, Colclough, Nicola, additional, Reddy, Venkatesh Pilla, additional, Sykes, Andrew, additional, Janefeldt, Annika, additional, Johnström, Peter, additional, Varnäs, Katarina, additional, Takano, Akihiro, additional, Ling, Stephanie, additional, Orme, Jonathan, additional, Stott, Jonathan, additional, Roberts, Caroline, additional, Barrett, Ian, additional, Jones, Gemma, additional, Roudier, Martine, additional, Pierce, Andrew, additional, Allen, Jasmine, additional, Kahn, Jenna, additional, Sule, Amrita, additional, Karlin, Jeremy, additional, Cronin, Anna, additional, Chapman, Melissa, additional, Valerie, Kristoffer, additional, Illingworth, Ruth, additional, and Pass, Martin, additional

Published
2018
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10. A SPECIFIC ANTIDOTE FOR TICAGRELOR

Author

Nylander, Sven, primary, Pehrsson, Susanne, additional, Inghardt, Tord, additional, Antonsson, Thomas, additional, Svensson, Peder, additional, Sjögren, Tove, additional, Öster, Linda, additional, Janefeldt, Annika, additional, Sandinge, Ann-Sofie, additional, Newton, Phil, additional, Keyes, Feenagh, additional, Austin, Mark, additional, and Buchanan, Andrew, additional

Published
2015
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13. Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG

Author

Bonn, Britta, Svanberg, Petter, Janefeldt, Annika, Hultman, Ia, and Grime, Ken

Abstract

A key requirement in drug discovery is to accurately define intrinsic clearance (CLint) values of less than 1 µl/min/106hepatocytes, which requires assays that allow for longer incubation time as a complement to suspended hepatocytes. This study assessed the effectiveness of plated HepaRG cells, plated primary human hepatocytes (PHHs), and the HµREL human hepatocyte/stromal cell co-cultures for determination of low CLintvalues. The investigation demonstrated that the systems were capable of providing statistically significant CLintestimations down to 0.2 µl/min/106cells. The HµREL assay provided a higher level of reproducibility, with repeat significant CLintvalues being defined in a minimum of triplicate consecutive assays for six of seven of the low CLintcompounds compared with four of seven for PHHs and two of seven for HepaRG. The assays were also compared with a suspension assay using drugs with higher CLintvalues and diverse enzymology. The CLintvalues from the PHH and HµREL assays were similar to those defined by a hepatocyte suspension assay, indicating that they can be used interchangeably alongside a standard assay. Finally, data from these two assays could also predict in vivo hepatic metabolic CLintto within 3-fold for greater than 70% of the compounds tested, with average fold errors (AFE) of 1.6 and 2.3, respectively, whereas the HepaRG data were predictive to within 3-fold for only 50% of compounds (AFE 2.9). In summary, all systems have utility for low CLintdetermination, but the HµREL co-culture appears slightly superior regarding overall assay performance.

Published
2016
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14. HepaRG Cells as Human-Relevant In Vitro Model to Study the Effects of Inflammatory Stimuli on Cytochrome P450 Isoenzymes

Author

Rubin, Katarina, Janefeldt, Annika, Andersson, Linda, Berke, Zsofia, Grime, Ken, and Andersson, Tommy B.

Abstract

The suppression of hepatic cytochrome P450 (P450) expression during inflammatory and infectious diseases and the relief of this suppression by successful disease treatment have been previously demonstrated to impact drug disposition. To address this clinically relevant phenomenon preclinically, the effect of proinflammatory cytokines on P450 isoenzymes in human hepatocytes has been examined by several researchers. In the present study we used the human hepatoma cell line (HepaRG) and cryopreserved primary human hepatocytes to investigate the effects of various inflammatory stimuli on P450 levels with the aim of further characterizing HepaRG cells as a useful surrogate for primary hepatocytes. In this study, HepaRG cells were exposed to bacterial lipopolysaccharide (LPS), interleukin-6 (IL-6), and interleukin-18 (IL-18) for 48 or 72 hours. The effects on CYP1A2, CYP2B6, and CYP3A4 mRNA and catalytic activity (phenacetin-O-deethylase, bupropion-hydroxylase, and midazolam-1′-hydroxylase) were measured. Cryopreserved pooled plateable hepatocytes were also exposed to IL-6 or IL-18 for 48 hours, and the effects on CYP1A2, CYP2B6, and CYP3A4 mRNA levels were measured. The exposure of HepaRG cells to IL-6 and LPS resulted in suppression of CYP1A2, CYP2B6, and CYP3A4 mRNA levels as well as their catalytic activities. However, no suppression of P450 activities or mRNA levels was observed after exposure to IL-18. Similar results on CYP1A2, CYP2B6, and CYP3A4 mRNA levels were observed with primary hepatocytes. The present study indicates that different proinflammatory mediators influence the expression of P450 differentially and that HepaRG cells may be used as an alternative to human hepatocytes for studies on cytokine-mediated suppression of drug-metabolizing enzymes.

Published
2015
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