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3. Synthesis of Vorinostat and cholesterol conjugate to enhance the cancer cell uptake selectivity

Author

Bin Su, Chunfang Gan, Jane Peterson, Paul Orefice, and Nethrie D. Idippily

Subjects
0301 basic medicine, Cell Survival, Clinical Biochemistry, Pharmaceutical Science, Hydroxamic Acids, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Tandem Mass Spectrometry, Cell Line, Tumor, Drug Discovery, medicine, Humans, Molecular Biology, Vorinostat, Chromatography, High Pressure Liquid, Cell Proliferation, Chemistry, Cholesterol, Organic Chemistry, Cancer, medicine.disease, Histone Deacetylase Inhibitors, 030104 developmental biology, Receptors, LDL, Apoptosis, 030220 oncology & carcinogenesis, Cancer cell, LDL receptor, Cancer research, Molecular Medicine, lipids (amino acids, peptides, and proteins), Histone deacetylase, Conjugate, medicine.drug
Abstract

Histone deacetylase (HDAC) inhibitors modulate various cellular functions including proliferation, differentiation, and apoptosis. Vorinostat (SuberAniloHydroxamic Acid, SAHA) is the first HDAC inhibitor approved by FDA for cancer treatment. However, SAHA distributes in cancer tissue and normal tissue in similar levels. It will be ideal to selectively deliver SAHA into cancer cells. Rapidly growing cancer cells have a great need of cholesterol. Low-density lipoprotein (LDL) is the major cholesterol carrier in plasma and its uptake is mediated by LDL-receptor (LDL-R), a glycoprotein overexpressed on the surface of cancer cells. Herein, we designed and synthesized a SAHA cholesterol conjugate, and further formed the conjugate containing particles with LDL as the carrier. The diameters of the particles were determined. The inhibitory activity of the particles carrying the conjugate was determined with cancer cell proliferation assay, and the hydrolysis of the conjugate by the enzymes in cancer cells was confirmed with LC-MS/MS.

Published
2017
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4. Determinants of Contraceptive Method Choice in Peninsular Malaysia, 1961–75

Author

Ramli Othman, Tan Boon Ann, Julie DaVanzo, and Jane Peterson

Subjects
business.industry, Female sterilization, Social change, Developing country, Gender studies, Family life, law.invention, Contraceptive use, Condom, Family planning, law, Pill, parasitic diseases, Medicine, business, Demography
Abstract

This Note documents the trend over the period 1961-75 in the mix of contraceptive methods used in Peninsular Malaysia by women aged 35 [and] younger and examines the influences on their choice of method over this period. Data are from the 1976-1977 Malaysian Family Life Survey. The authors note that contraceptive use increased significantly over this period. "The greatest increase occurred for the pill. By the mid-1970s oral contraceptives accounted for over one-half of the total time Malaysian women were protected by some form of contraception. Female sterilization and condom use also increased over this period." Factors affecting the choice of method are assessed. (EXCERPT)

Published
2019
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5. Woman's Share in Neolithic Society: A View from the Southern Levant

Author

Jane Peterson

Subjects
010506 paleontology, Archeology, History, 060102 archaeology, Southern Levant, business.industry, 06 humanities and the arts, Ancient history, 01 natural sciences, Geography, Agriculture, Period (geology), 0601 history and archaeology, business, 0105 earth and related environmental sciences
Abstract

Early farming groups set into motion substantial, even revolutionary, socioeconomic changes during the Pre-Pottery Neolithic period (ca. 10,500–6,000 cal. B.C.E.) in the southern Levant of Southwes...

Published
2016
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6. Multiple approaches to the treatment of violent couples

Author

Jennings, Jane Peterson and Jennings, Jerry L.

Subjects
Conjugal violence -- Care and treatment, Marital psychotherapy -- Methods, Family and marriage, Psychology and mental health
Abstract

The first step in treating violent couples is to determine which of the three basic approaches is most suitable for the client: unilateral (noninteractive treatment of the individual); bilateral (noninteractive treatment of each partner separately); and dyadic (mutual and interactive conjoint treatment). Accurate assessment using defined criteria is absolutely crucial in order to ascertain whether the couple can or cannot be treated together safely. A broad array of established clinical techniques (specific to aggressive couples) can be utilized within each of the three designated modalities. Both assessment criteria and specific clinical techniques are described.

Published
1991

14. The International HapMap Project

Author

Jessica Watkin, Stacey Gabriel, Norio Niikawa, Michael Boehnke, Lincoln Stein, Karen Kennedy, Mark Leppert, Renzong Qiu, John Stewart, Peter E. Chen, Panos Deloukas, Wei Huang, Deborah A. Nickerson, Fuli Yu, Sarah E. Hunt, Ming Xiao, Francis S. Collins, Fiona Cunningham, Stephen F. Schaffner, Yoshimitsu Fukushima, Jonathan Marchini, Troy Duster, Jane Peterson, Koki Sorimachi, Michael Feolo, Bruce S. Weir, Paul L'Archevêque, Raymond D. Miller, Hongguang Wang, Toyin Aniagwu, Mildred K. Cho, Darryl Macer, Qingrun Zhang, Paul K.H. Tam, Ardavan Kanani, Guy Bellemare, Thomas D. Willis, Mark Shillito, Martin Leboeuf, Lynn F. Zacharia, Pilar N. Ossorio, Charmaine D.M. Royal, Paul Hardenbol, Yusuke Nakamura, Maria Jasperse, Pui-Yan Kwok, Mark S. Guyer, Bin Liu, Leonid Kruglyak, Huanming Yang, Aravinda Chakravarti, John W. Belmont, Ellen Wright Clayton, Jane Rogers, Arnold Oliphant, Jack Spiegel, Houcan Zhang, Stephen T. Sherry, Vincent Ferretti, Julio Licinio, Toshihiro Tanaka, Richard R. Hudson, Mary M.Y. Waye, Lon R. Cardon, Elke Jordan, Gonçalo R. Abecasis, Kazuto Kato, Vivian Ota Wang, Gilean McVean, Lawrence M. Sung, Don Powell, Patricia A. Marshall, Patricia Spallone, Lan Yang Ch'Ang, Alastair Kent, James C. Mullikin, Eric S. Lander, Lucinda Fulton, Michael S. Phillips, Jeffrey Tze Fei Wong, David Valle, Fanny Chagnon, Semyon Kruglyak, Tatsuhiko Tsunoda, Hua Han, John P. Rice, David J. Cutler, Mark J. Daly, Peter Donnelly, Yan Shen, Jean E. McEwen, Andrew P. Morris, Richard Seabrook, Luana Galver, Thomas J. Hudson, Chibuzor Nkwodimmah, Clement Adebamowo, Lisa D. Brooks, Arthur L. Holden, Robert L. Nussbaum, David R. Bentley, Jeffrey C. Long, Nancy L. Saccone, Michael Dunn, Charles N. Rotimi, Sarah S. Murray, Richard A. Gibbs, Simon Myers, George M. Weinstock, Bartha Maria Knoppers, Takashi Fujita, Julie A. Douglas, Georgia M. Dunston, Richard K. Wilson, Sharon F. Terry, Kazuo Todani, Akihiro Sekine, Barbara Skene, Martin Godbout, David Altshuler, Bruce W. Birren, Lynn B. Jorde, Mark S. Chee, Olayemi Matthew, Erica Sodergren, Lap-Chee Tsui, Changqing Zeng, John C. Wallenburg, Missy Dixon, Gudmundur A. Thorisson, Ichiro Matsuda, Andrei Verner, Carl S. Kashuk, Eiji Yoshino, Patricia Taillon-Miller, Morris W. Foster, Satoshi Tanaka, Alexandre Montpetit, Yoichi Tanaka, Denise L. Lind, Eric H. Lai, Eiko Suda, and Shenghui Duan

Subjects
Multidisciplinary, Public Sector, Base Sequence, Genome, Human, International Cooperation, Racial Groups, Genetic Variation, Genomics, Single-nucleotide polymorphism, Computational biology, DNA, Biology, Genome, Polymorphism, Single Nucleotide, Gene Frequency, Haplotypes, Humans, Human genome, Copy-number variation, International HapMap Project, Haplotype estimation, Imputation (genetics)
Abstract

The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these patterns across the genome by determining the genotypes of one million or more sequence variants, their frequencies and the degree of association between them, in DNA samples from populations with ancestry from parts of Africa, Asia and Europe. The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance our ability to choose targets for therapeutic intervention. © 2003 Nature Publishing Group.

Published
2016

15. A framework for human microbiome research

Author

Rosamond Rhodes, Asif T. Chinwalla, Tessa Madden, Ashlee M. Earl, Maria C. Rivera, Candace N. Farmer, Jonathan M. Goldberg, Karthik Kota, Victor Felix, Nicholas B. King, Shibu Yooseph, Erica Sodergren, Monika Bihan, Martin J. Blaser, Dirk Gevers, Dan Knights, Pamela Sankar, Anup Mahurkar, Heather Huot Creasy, Veena Bhonagiri, Thomas M. Schmidt, Curtis Huttenhower, Mina Rho, Todd J. Treangen, Thomas J. Sharpton, I. Min A. Chen, Bo Liu, Sarah K. Highlander, Catherine C. Davis, Susan M. Huse, Richard A. Gibbs, Noam J. Davidovics, Patricio S. La Rosa, Carsten Russ, Wesley C. Warren, Richard K. Wilson, Patrick Minx, Jean E. McEwen, Alyxandria M. Schubert, Scott Anderson, Bonnie P. Youmans, Jamison McCorrison, Kathie A. Mihindukulasuriya, Vandita Joshi, Peter J. Mannon, Brandi L. Cantarel, Joseph F. Petrosino, Jack D. Sobel, Chandri Yandava, Sharvari Gujja, Janet K. Jansson, David J. Dooling, Daniel McDonald, Rob Knight, Granger G. Sutton, Gary C. Armitage, Larry J. Forney, Robert S. Fulton, Yuan Qing Wu, Jonathan Crabtree, Susan Kinder-Haake, Lu Wang, Liang Ye, Victor M. Markowitz, Narmada Shenoy, Elizabeth A. Lobos, Ruth M. Farrell, Tatiana A. Vishnivetskaya, Patrick S. G. Chain, Jacques Ravel, Katherine H. Huang, Sergey Koren, Yan Ding, Christina Giblin, Jason R. Miller, Michelle G. Giglio, Gina A. Simone, Chad Nusbaum, Lynn M. Schriml, Matthew C. Ross, Daniel D. Sommer, Sandra L. Lee, Theresa A. Hepburn, Michael Holder, Shaila Chhibba, Patrick D. Schloss, Omry Koren, Lan Zhang, Catrina Fronick, Richard R. Sharp, Diana Tabbaa, Yuzhen Ye, Dennis C. Friedrich, Christie Kovar, Owen White, A. Scott Durkin, Michael Feldgarden, Gary L. Andersen, Makedonka Mitreva, Todd Wylie, Nihar U. Sheth, Sheila Fisher, John Martin, Jose C. Clemente, Xiang Qin, James Versalovic, Dana A. Busam, Bruce W. Birren, Jeremy Zucker, Yu-Hui Rogers, Shannon Dugan, Kristine M. Wylie, Katherine P. Lemon, Floyd E. Dewhirst, Nicola Segata, Konstantinos Liolios, Anthony A. Fodor, Elizabeth L. Appelbaum, Ramana Madupu, W. Michael Dunne, Katherine S. Pollard, Leslie Foster, Olukemi O. Abolude, Yue Liu, Nikos C. Kyrpides, Christopher Wellington, Yanjiao Zhou, Lita M. Proctor, Tsegahiwot Belachew, Mircea Podar, Julia A. Segre, Holli A. Hamilton, Aye Wollam, Paul Spicer, Lei Chen, Sarah Young, Beltran Rodriguez-Mueller, Todd Z. DeSantis, Sean M. Sykes, Toby Bloom, Kelvin Li, Shane Canon, Catherine Jordan, Manolito Torralba, Brandi Herter, R. Dwayne Lunsford, Krishna Palaniappan, Jeroen Raes, Hongyu Gao, Barbara A. Methé, Kjersti Aagaard, Amy L. McGuire, Jonathan Friedman, Matthew D. Pearson, Jason Walker, Mary A. Cutting, Jonathan H. Badger, Diane E. Hoffmann, Tulin Ayvaz, Michael Fitzgerald, Brian J. Haas, Ravi Sanka, Doyle V. Ward, Kris A. Wetterstrand, Mark A. Watson, Christopher Smillie, Lucinda Fulton, Zhengyuan Wang, Lisa Begg, James R. White, Konstantinos Mavrommatis, Lucia Alvarado, Pamela McInnes, Emily L. Harris, Harindra Arachchi, Craig Pohl, Catherine A. Lozupone, Ruth E. Ley, Clinton Howarth, Yiming Zhu, Huaiyang Jiang, Gregory A. Buck, Carl C. Baker, Kimberley D. Delehaunty, Cristyn Kells, Katarzyna Wilczek-Boney, Kim C. Worley, Cesar Arze, J. Fah Sathirapongsasuti, Carolyn Deal, Sandra W. Clifton, Ken Chu, Rachel L. Erlich, Elaine R. Mardis, Cecil M. Lewis, Niall Lennon, Margaret Priest, Scott T. Kelley, Kymberlie Hallsworth-Pepin, Jane Peterson, Allison D. Griggs, Michelle O'Laughlin, Heidi H. Kong, Joshua Orvis, Maria Y. Giovanni, Sahar Abubucker, Dawn Ciulla, Sean Conlan, Chien Chi Lo, Antonio Gonzalez, Georgia Giannoukos, Jennifer R. Wortman, Paul Brooks, Jacques Izard, Chad Tomlinson, Donna M. Muzny, Shital M. Patel, Eric J. Alm, George M. Weinstock, Irene Newsham, Jeffrey G. Reid, Karoline Faust, Qiandong Zeng, Elena Deych, Nathalia Garcia, Mathangi Thiagarajan, James A. Katancik, Vivien Bonazzi, Robert C. Edgar, Christian J. Buhay, Indresh Singh, Johannes B. Goll, Ioanna Pagani, Vincent Magrini, Wendy A. Keitel, Emma Allen-Vercoe, Teena Mehta, Jeffery A. Schloss, William D. Shannon, Mihai Pop, Matthew B. Scholz, Valentina Di Francesco, Rebecca Truty, Karen E. Nelson, Kevin Riehle, Lora Lewis, Joseph L. Campbell, Laurie Zoloth, Massachusetts Institute of Technology. Computational and Systems Biology Program, Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Civil and Environmental Engineering, Friedman, Jonathan, Smillie, Chris Scott, and Alm, Eric J.

Subjects
Adult, Male, Adolescent, Statistics as Topic, Population, Computational biology, Biology, Genome, Article, Young Adult, 03 medical and health sciences, Human health, 0302 clinical medicine, RNA, Ribosomal, 16S, Humans, Microbiome, education, 030304 developmental biology, Genetics, 0303 health sciences, education.field_of_study, Multidisciplinary, Bacteria, Human microbiome, Reference Standards, Metagenomics, 030220 oncology & carcinogenesis, Earth Microbiome Project, Metagenome, Female, Human Microbiome Project
Abstract

A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project Consortium has established a population-scale framework to develop metagenomic protocols, resulting in a broad range of quality-controlled resources and data including standardized methods for creating, processing and interpreting distinct types of high-throughput metagenomic data available to the scientific community. Here we present resources from a population of 242 healthy adults sampled at 15 or 18 body sites up to three times, which have generated 5,177 microbial taxonomic profiles from 16S ribosomal RNA genes and over 3.5 terabases of metagenomic sequence so far. In parallel, approximately 800 reference strains isolated from the human body have been sequenced. Collectively, these data represent the largest resource describing the abundance and variety of the human microbiome, while providing a framework for current and future studies.

Published
2012

16. Domesticating gender: Neolithic patterns from the southern Levant

Author

Jane Peterson

Subjects
Archeology, History, Middle East, Osteology, Southern Levant, Anthropology, media_common.quotation_subject, Human Factors and Ergonomics, Literal and figurative language, Ideology, Architecture, Social organization, Domestication, media_common
Abstract

This paper examines the extant evidence regarding gender reconstructions and relations for the Neolithic of the southern Levant of southwest Asia. Data from human skeletal remains, mortuary contexts, architecture, and figurative art provide the empirical bases for a broad assessment of gender in the realms of productive labor, social organization, and ideology. Overall, little evidence is found to support that Neolithic societies in this region were organized hierarchically in terms of gender.

Published
2010
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17. The NIH Human Microbiome Project

Author

Valentina Di Francesco, Jean E. McEwen, Carl C. Baker, Jeffery A. Schloss, Samir Zakhari, Susan Garges, Bracie Watson, Tsegahiwot Belachew, Kris A. Wetterstrand, Matthew E. Portnoy, Michael H. Sayre, A. Roger Little, Beena Akolkar, Carolyn Deal, Lindsey Grandison, Jane Peterson, Michael Wright, Lisa Begg, Jag H. Khalsa, Pamela Starke-Reed, Rachelle Salomon, Jennifer S. Read, Hannah Peavy, Robert W. Karp, T. Kevin Howcroft, Christina Giblin, Chris Mullins, Cindy D. Davis, Pamela McInnes, Christopher Wellington, Lu Wang, R. Dwayne Lunsford, Melody Mills, Hagit David, Maria Y. Giovanni, Carol H. Pontzer, Vivien Bonazzi, Michael C. Humble, and Mark S. Guyer

Subjects
Resource, Knowledge management, National Health Programs, Biology, Bioinformatics, Human health, Resource (project management), RNA, Ribosomal, 16S, Genetics, Humans, Microbiome, Genetics (clinical), Skin, Mouth, Bacteria, NIH Roadmap, business.industry, Human microbiome, Sequence Analysis, DNA, United States, Gastrointestinal Tract, National Institutes of Health (U.S.), Metagenomics, Earth Microbiome Project, Vagina, Metagenome, Female, business, Human Microbiome Project
Abstract

The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource. The goals of the HMP are: (1) to take advantage of new, high-throughput technologies to characterize the human microbiome more fully by studying samples from multiple body sites from each of at least 250 “normal” volunteers; (2) to determine whether there are associations between changes in the microbiome and health/disease by studying several different medical conditions; and (3) to provide both a standardized data resource and new technological approaches to enable such studies to be undertaken broadly in the scientific community. The ethical, legal, and social implications of such research are being systematically studied as well. The ultimate objective of the HMP is to demonstrate that there are opportunities to improve human health through monitoring or manipulation of the human microbiome. The history and implementation of this new program are described here.

Published
2009
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18. Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Author

Sandy Aronson, Leslie Cope, Michael L. Bittner, Daniel C. Koboldt, Alex E. Lash, W. K. Alfred Yung, Margaret Morgan, Devin Absher, Carl F. Schaefer, Roger E. McLendon, Michael D. Prados, Josh Gould, Ju Han, Stacey Gabriel, Scott R. VandenBerg, Ilana Perna, Troy Shelton, Junyuan Wu, Sacha Scott, Steve Scherer, Michael J. T. O’Kelly, Li Ding, Erin Hickey, Elizabeth J. Thomson, Bahram Parvin, Kim D. Delehaunty, Gi Choi Yoon, Mark D. Robinson, Oliver Bogler, Darrell D. Bigner, Michael R. Reich, Jianhua Zhang, Robert S. Fulton, Allan H. Friedman, Tammi L. Vickery, Amita Aggarwal, Subhashree Madhavan, Liuda Ziaugra, Yuan Qi, Vandita Joshi, Eric Van Name, Jane Wilkinson, W. Ruprecht Wiedemeyer, Xiaoqi Shi, Richard A. Gibbs, Lynda Chin, Jessica Chen, Stefano Monti, Erwin G. Van Meir, John Ngai, Amy Hawkins, Elizabeth Lenkiewicz, Brad Ozenberger, Shannon Dorton, Georgia Ren, John N. Weinstein, Gena M. Mastrogianakis, Asif T. Chinwalla, Scott L. Carter, Nicholas D. Socci, Rachel Abbott, Gavin Sherlock, Lucinda Fulton, Hyun Soo Kim, Fei Pan, Magali Cavatore, Gabriele Alexe, Francis S. Collins, Narayanan Sathiamoorthy, Lakshmi Jakkula, Brian H. Dunford-Shore, Jireh Santibanez, Tom Mikkelsen, Huy V. Nguyen, Levi A. Garraway, Christopher A. Miller, Jinghui Zhang, Ken Chen, Timothy Fennell, Robert Sfeir, James A. Robinson, Alexey Stukalov, Richard K. Wilson, Matthew Meyerson, Daniel J. Weisenberger, Mi Yi Joo, Yevgeniy Antipin, Anna Lapuk, Gerald V. Fontenay, Nicolas Stransky, Adam B. Olshen, Elizabeth Purdom, Josh Korn, Huyen Dinh, Sai Balu, Victoria Wang, James G. Herman, Christie Kovar, Kristian Cibulskis, Tisha Chung, Agnes Viale, Paul T. Spellman, Supriya Gupta, Melissa Parkin, Peter J. Park, Maddy Wiechert, John W. Wallis, Peter W. Laird, Nikolaus Schultz, James D. Brooks, David Nassau, Jun Li, John R. Osborne, Anna D. Barker, Peter Fielding, Boris Reva, Karen Vranizan, D. Neil Hayes, Aleksandar Milosavljevic, Lawrence A. Donehower, Won Kong Sek, Daniela S. Gerhard, Otis Hall, Rameen Beroukhim, Audrey Southwick, George M. Weinstock, Chris Markovic, Roel G.W. Verhaak, David Van Den Berg, Joe W. Gray, Yanru Ren, Ethan Cerami, Yiming Zhu, Amrita Ray, Yonghong Xiao, Kristin G. Ardlie, William L. Gerald, Michael S. Lawrence, Gerald R. Fowler, Mark S. Guyer, Isaac S. Kohane, Kornel E. Schuebel, Mitchel S. Berger, Jeffrey J. Olson, Gary W. Swift, Lora Lewis, Sheri Sanders, Norman L. Lehman, Eric S. Lander, Robert Penny, Liliana Villafania, John G. Conboy, Ari B. Kahn, Henry Marr, Heidi S. Feiler, Lynn Nazareth, David J. Dooling, Katherine A. Hoadley, Alicia Hawes, Marc Ladanyi, Aniko Sabo, Wendy Winckler, Vivian Peng, Barbara A. Weir, Daniel J. Brat, Scott Morris, Carolyn C. Compton, Todd R. Golub, Scott Abbott, Michael D. McLellan, Jiqiang Yao, Shalini N. Jhangiani, Michael D. Topal, Michael C. Wendl, Gad Getz, Jun Yao, Derek Y. Chiang, Larry Feng, Steffen Durinck, David A. Wheeler, Yuzhu Tang, Benjamin Gross, Barry S. Taylor, Kenneth Aldape, Craig Pohl, Rick Meyer, Peter J. Good, Ling Lin, Elaine R. Mardis, Robert C. Onofrio, Jane Peterson, Stephen B. Baylin, Li-Xuan Qin, Andrew Cree, Cameron Brennan, Charles M. Perou, William Courtney, Omar Alvi, Donna M. Muzny, Joseph G. Vockley, Jill P. Mesirov, Yan Shi, Alexei Protopopov, Jim Vaught, Craig H. Mermel, Scott Mahan, Laetitia Borsu, Heather Schmidt, Jennifer Baldwin, Tracie L. Miner, Toby Bloom, David E. Larson, Leander Van Neste, Nicholas J. Wang, Kenneth H. Buetow, Raju Kucherlapati, Anthony San Lucas, Martin L. Ferguson, Terence P. Speed, Venkatraman E. Seshan, Debbie Beasley, Carrie Sougnez, Carrie A. Haipek, Richard M. Myers, Chris Sander, Qing Wang Wei, Jon G. Seidman, Rob Nicol, Manuel L. Gonzalez-Garay, Shin Leong, Shannon T. Brady, and University of Groningen

Subjects
Male, Models, Molecular, DNA Repair, Gene Dosage, NEUROFIBROMATOSIS TYPE-1, MISMATCH REPAIR, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Genes, Tumor Suppressor, DNA Modification Methylases, Proneural Glioblastoma, Aged, 80 and over, Genetics, 0303 health sciences, Neurofibromin 1, Multidisciplinary, Brain Neoplasms, NF1 GENE, Genomics, Middle Aged, TUMORS, ALKYLATING-AGENTS, 3. Good health, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, DNA methylation, Female, DNA mismatch repair, Functional genomics, Signal Transduction, Adult, Adolescent, CELL-LINES, Oncogenomics, Biology, Article, 03 medical and health sciences, PIK3CA GENE, Humans, Epigenetics, Gene, Aged, Retrospective Studies, 030304 developmental biology, HIGH-FREQUENCY, Genome, Human, Tumor Suppressor Proteins, SOMATIC MUTATIONS, Genes, erbB-1, DNA Methylation, Protein Structure, Tertiary, MALIGNANT GLIOMAS, DNA Repair Enzymes, Mutation, Glioblastoma
Abstract

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas ( TCGA) pilot project aims to assess the value of large- scale multi- dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community. Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas - the most common type of primary adult brain cancer - and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 and TP53, uncovers frequent mutations of the phosphatidylinositol- 3- OH kinase regulatory subunit gene PIK3R1, and provides a network view of the pathways altered in the development of glioblastoma. Furthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications. Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.

Published
2008
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19. Agriculture, beginnings of

Author

Jane Peterson

Subjects
Sexual identity, Grave goods, business.industry, Reproduction (economics), media_common.quotation_subject, Gender studies, Environmental ethics, Fertility, Geography, Agriculture, Ideology, Architecture, business, media_common
Abstract

The transition from hunting and gathering to farming represented a fundamental transition in the human career. No doubt this transformation had profound impacts on how sexual identity, labor, status, and ideology were defined. Human representations, osteological material, grave goods, and architecture have been examined to shed light on these impacts. Keywords: fertility; figurines; reproduction

Published
2015
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20. Relations between Incidence of Specific Diseases and Body Build of Young Women

Author

Jane Peterson, Säde Koskel, and Helje Kaarma

Subjects
Gerontology, business.industry, Dermatological diseases, Incidence (epidemiology), Concordance, Urological Diseases, Disease, Anthropometry, Health promotion, Arts and Humanities (miscellaneous), Anthropology, Medicine, Otorhinolaryngologic Diseases, business
Abstract

The paper studies the relations between the body build of women between the ages of 17 and 23 (university entrants, first-and second-year students, n = 724) and the diseases affecting them. The subjects' weight, height and 40 anthropometric variables were measured, from which seven indices of body composition were calculated. Individual anthropometric characteristics were systematized into a SD classification of five classes - small, medium, large, pycnomorphous and leptomorphous. The subjects were interviewed about eight main groups of disease to find the specific diseases they had suffered from and the total number of cases (n = 1270). Incidence of diseases was assessed in the body build classes into which the subjects had been classified according to their anthropometric data. We found that pycnomorphous and leptomorphous young women were affected by cardiovascular, urological, surgical and otorhinolaryngologic diseases statistically significantly more often. When checking the number of subjects who had been affected by one to four or more diseases, the same tendency appeared: in the classes of pycnomorphs and leptomorphs incidence of diseases was significantly higher than in other classes. Such results hint at a constitutional peculiarity and that suggest that height and weight and concordance or disconcordance between them may have an essential influence on young women's health. Key Words: young women, anthropometry, body build, height-weight classes, incidence of Cardiovascular diseases, Pulmonological diseases, Gatrointestinal diseases, Urological diseases, Surgical diseases, Dermatological diseases, Opthalmological diseases, and Otorhinolaryngological diseases. Introduction Specialist literature in Estonia is paying increasing attention to relations between anthropometric peculiarities and health (Kaarma and Raud 1977; Kaarma et al. 1998, 1999, 2001; Kask 1998; Maiste 1999; Peterson and Koskel 2000). For broader application of such studies in health promotion and medicine, a classification is needed which would facilitate simultaneous systematization of a great number of anthropometric and health variables. The Centre for Physical Anthropology at the University of Tartu has been engaged in studies of body anthropometric structure for a long time (Kaarma 1981, 1995; Kaarma et al. 1997). The samples studied include schoolgirls aged 7-18 (Maiste et al. 1999; Veldre et al. 2002; Kasmel et al. 2004), young women (Kaarma et al. 1996, 2000), schoolboys aged 17-18 and conscripts (Lintsi et al. 2002; Lintsi and Kaarma 2003). Our research has confirmed that in all the age groups studied, the anthropometric structure of body build consists of a number of mutually statistically significantly related measurements where the leading variables are height and weight. By classifying the anthropometric variables of different samples into a 5 SD classification, we have managed to systematize all length, breadth and depth measurements, circumferences, indices and body composition characteristics. The aim of the present paper is to study how this classification could be applied to young women aged 17-23 years (university entrants as well as first- and second-year students) and to find whether the classification could be used for assessment of incidence of diseases from which they have suffered. This is the first time we present a paper on the relation between body build and incidence of diseases in an international publication. Material and Methods Subjects The sample under study consisted of 724 young women aged 17-23 years. They were entrants to the University of Tartu and its first- or second-year students. Measurement Procedures: 1. Anthropometric Research All the subjects were measured by Martin's classical method (Martin 1928) by the first author of the paper, Jana Peterson, at the Health Centre of the University of Tartu. Weight and 48 other anthropometric measurements were taken: 8 length measurements, 10 breadth and depth measurements, 18 circumferences and 10 skinfolds. …

Published
2006
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21. A haplotype map of the human genome

Author

Mark Leppert, Aravinda Chakravarti, Charmaine D.M. Royal, Sarah S. Murray, Renzong Qiu, Panos Deloukas, Renwu Wang, David A. Hinds, Barbara E. Stranger, Xiaoli Tang, Huanming Yang, John W. Belmont, Nigel P. Carter, Huy Nguyen, William Mak, Kazuto Kato, Shiran Pasternak, Chaohua Li, Jeffrey C. Barrett, Lon R. Cardon, Vincent Ferretti, Atsushi Nagashima, Peter E. Chen, Stephen F. Schaffner, Hongbo Fu, Zhu Chen, Siqi Liu, John Burton, Paul Hardenbol, Gudmundur A. Thorisson, Yusuke Nakamura, Mark Griffiths, Imtiaz Yakub, Eiko Suda, Gonçalo R. Abecasis, Carl S. Kashuk, Qingrun Zhang, Yoshimitsu Fukushima, Karen Kennedy, Sarah E. Hunt, Yi Wang, Norio Niikawa, Ichiro Matsuda, Lynn F. Zacharia, Lalitha Krishnan, Zhen Wang, Stéphanie Roumy, C M Clee, David J. Cutler, Albert V. Smith, Lincoln Stein, Simon Myers, Jane Peterson, Jun Zhou, Yozo Ohnishi, Weihua Guan, Matthew Stephens, Xiaoyan Xiong, Julian Maller, Houcan Zhang, Pui-Yan Kwok, Mark S. Guyer, Liuda Ziaugra, Jonathan Witonsky, Matthew C. Jones, Stacey Gabriel, You-Qiang Song, Daochang An, Haifeng Wang, Gilean McVean, Lawrence M. Sung, Zhijian Yao, Yan Shen, Yangfan Liu, George M. Weinstock, Ludmila Pawlikowska, Erica Sodergren, Mark T. Ross, Andrew Boudreau, Toshihiro Tanaka, Thomas D. Willis, Weitao Hu, Kelly A. Frazer, Li Jin, Robert W. Plumb, Paul I.W. de Bakker, Hongbin Zhao, Wei Lin, Sarah Sims, Richard A. Gibbs, Maura Faggart, Michael Feolo, Dennis G. Ballinger, Xun Chu, Lucinda Fulton, Marcos Delgado, Ellen Winchester, Wei Huang, Fuli Yu, Christianne R. Bird, Shaun Purcell, Jessica Roy, Dongmei Cai, Launa M. Galver, Bartha Maria Knoppers, Emmanouil T. Dermitzakis, Gao Yang, Takashi Morizono, Rachel Barry, Kirsten McLay, Daryl J. Thomas, Steve McCarroll, Jonathan Marchini, Daniel J. Richter, Andy Peiffer, Patricia Taillon-Miller, Richard K. Wilson, Stephen Kwok-Wing Tsui, Jian-Bing Fan, Lisa D. Brooks, Laura L. Stuve, Paul L'Archevêque, David M. Evans, Clémentine Sallée, Peter Donnelly, Hong Xue, Hui Zhao, Charles N. Rotimi, Jean E. McEwen, J. Tze Fei Wong, Hao Pan, Alastair Kent, Brendan Blumenstiel, Qing Li, Weiwei Sun, L. Kang, Colin Freeman, John Stewart, Chibuzor Nkwodimmah, Morris W. Foster, Don Powell, Leonardo Bottolo, Raymond D. Miller, Stephen T. Sherry, Francis S. Collins, Donna M. Muzny, Jun Yu, Ike Ajayi, Hua Han, Pardis C. Sabeti, Hongguang Wang, Takahisa Kawaguchi, Tatsuhiko Tsunoda, Guy Bellemare, Zhaohui S. Qin, H. B. Hu, Jane Rogers, Thomas J. Hudson, Mark J. Daly, Andrew P. Morris, Supriya Gupta, Ming Xiao, Patrick Varilly, Nick Patterson, Akihiro Sekine, Chris C. A. Spencer, Jonathan Morrison, Missy Dixon, Paul K.H. Tam, Jian Wang, Matthew Defelice, Susana Eyheramendy, Michael Shi, Yungang He, Ellen Wright Clayton, Richa Saxena, Heather M. Munro, Arthur L. Holden, Yayun Shen, Christine P. Bird, Bruce W. Birren, Itsik Pe'er, David R. Bentley, Lynne V. Nazareth, Pamela Whittaker, Pak C. Sham, Amy L. Camargo, David A. Wheeler, Koji Saeki, Martin Godbout, David Altshuler, Liang Xu, Ying Wang, David Willey, Alexandre Montpetit, Shin Lin, Michael S. Phillips, Changqing Zeng, Clement Adebamowo, John C. Wallenburg, Mark S. Chee, Ben Fry, Erich Stahl, Melissa Parkin, Rhian Gwilliam, Andrei Verner, Patrick J. Nailer, Lap-Chee Tsui, Bo Zhang, Fanny Chagnon, David R. Cox, Jack Spiegel, Jamie Moore, Vivian Ota Wang, Patricia A. Marshall, Takuya Kitamoto, Bruce S. Weir, Darryl Macer, Geraldine M. Clarke, Robert C. Onofrio, Mary M.Y. Waye, Wei Wang, Suzanne M. Leal, James C. Mullikin, Toyin Aniagwu, Daniel C. Koboldt, Mary Goyette, Martin Leboeuf, Isaac F. Adewole, Ruth Jamieson, Arnold Oliphant, Jessica Watkin, and Jean François Olivier

Subjects
Linkage disequilibrium, Biology, DNA, Mitochondrial, Polymorphism, Single Nucleotide, Article, Linkage Disequilibrium, Structural variation, Gene Frequency, Humans, Selection, Genetic, International HapMap Project, Genetic association, Haplotypes - genetics, Recombination, Genetic, Genetics, Chromosomes, Human, Y, Multidisciplinary, Genome, Human, DNA, Mitochondrial - genetics, Haplotype, Tag SNP, Polymorphism, Single Nucleotide - genetics, Haplotypes, Human genome, Haplotype estimation, Chromosomes, Human, Y - genetics
Abstract

Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbours. We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution. © 2005 Nature Publishing Group., link_to_OA_fulltext

Published
2005
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22. Khirbet Hammam (WHS 149): A Late Pre-Pottery Neolithic B Settlement in the Wadi el-Hasa, Jordan

Author

Jane Peterson

Subjects
Cultural Studies, Archeology, History, geography, geography.geographical_feature_category, Southern Levant, business.industry, Excavation, Ancient history, Archaeology, law.invention, Pre-Pottery Neolithic, Agriculture, law, Radiocarbon dating, Settlement (litigation), business, Wadi
Abstract

Our knowledge of the archaeological landscape from the Late Pre-Pottery Neolithic B (LPPNB) of the southern Levant has expanded considerably as a result of survey and excavation projects carried out over the last two decades. As a result, cultural reconstructions of these early agricultural societies have become more complex and multifaceted. The social and economic solutions forged by farmers within the Levantine Corridor included some widely shared practices while, at the same time, reflected considerable regional variation. Here the results from the first excavations at Khirbet Hammam in the Wadi el-Hasa, dating to at least 8,300 radiocarbon years b.p., are reported. The site contains impressive standing architecture, well-preserved faunal remains, and diverse lithic assemblages. These materials are helping to paint an accurate picture of life in the upland agricultural villages.

Published
2004
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23. Enabling the genomic revolution in Africa

Author

Anh Quynh Nguyen, Daniel T. Lackland, Gustave Simo, Oumar Samassekou, Lukman Owolabi, Faisal M. Fadlelmola, Matthias Kretzler, Victoria Adabayeri, Jeffrey B. Kopp, Mary T Mayige, Mark S. Guyer, Charlotte Osafo, Nigel J. Crowther, Winston Hide, Eyitayo Fakunle, Guillaume Paré, Issa Sidibe, Bamidele O. Tayo, Manmak Mamven, Stephen Tollman, Christian T. Happi, Anne Fischer, James A. G. Whitworth, Andrew Tareila, Moses Joloba, Kristian G. Andersen, Odile Ouwe Missi Oukem-Boyer, Paul L. Kimmel, Thuli Mthiyane, Anita Ghansah, Sylvester Leonard Lyantagaye, T O Olanrewaju, John Enyaru, Kwamena W. Sagoe, Maia Lesosky, Neil A. Hanchard, Rita T. Lawlor, Ellis Owusu-Dabo, Eileen Obe, Shiksha Reddy, Margaret B. Penno., Rembert Pieper, Maria Y. Giovanni, Louise Wideroff, Yasmina Jaufeerally-Fakim, Marape Marape, Stacy Carrington-Lawrence, Oyekanmi Nash, Dwomoa Adu, Rebekah S. Rasooly, Rajkumar Ramesar, Mukthar Kader, Carolyn Jenkins, Simani Gaseitsiwe, Michèle Ramsay, Betty Nsangi, Olukemi K. Amodu, Mark P. Nicol, Adeodata Kekitiinwa, Thomas Lehner, Nzovu Ulenga, Saidi Kapiga, Victor Jongeneel, Gebregziabher Mulugeta, Nathan L. Yozwiak, Gabriel Anabwani, Solomon F. Ofori-Acquah, Misaki Wayengera, Rasheed Bakare, Marianne Alberts, Jantina de Vries, Robert F. Garry, Marsha Treadwell, Robert Kleta, Eugene Sobngwi, Ezra Susser, Mo Nagdee, Carmen Swanepoel, Osman Sankoh, Masego Tsimako-Johnstone, Godfred Tangwa, Zané Lombard, Darren P. Martin, Donald S. Grant, Bernard Keavney, Mahamadou Traoré, Ahmed El Sayed, Seth O. McLigeyo, Charles Mondo, Dan J. Stein, Özlem Tastan Bishop, Jane Peterson, Ute Jentsch, Moffat Nyirenda, Charles N. Rotimi, Shane A. Norris, Chengetai R. Mahomva., Gobena Ameni, Sheryl A. McCurdy, M Boehnke, Sally N Akarolo-Anthony, Oumou Sow Bah, Muntaser E. Ibrahim, Ishmael Kasvosve, Dean Everett, Kathleen Kahn, S.W.O. Ogendo, Abraham Oduro, Cheryl A. Winkler, Robin Mason, Orlando Alonso Betancourt, Hugh-G. Patterton, Heather J. Zar, John Oli, Audrey Duncanson, Daouda Ndiaye, Alan Christoffels, Adebowale Adeyemo, Kenneth H. Fischbeck, Manjinder S. Sandhu, Kwaku Ohene-Frempong, Samuel Ajayi, Chester W. Brown, Godfred Agongo, Tunde Salako, Ablo Prudence Wachinou, Gasnat Shaboodien, Pardis C. Sabeti, Jean Claude Mbanya, Peter Donkor, Dieuodonne Mumba, Heather J. Cordell, Sarah Winnicki, Reginald Obiakor, Fourie Joubert, Samar K. Kassim, Mark I. McCarthy, Scott Hazelhurst, Pontiano Kaleebu, Richard S. Cooper, Jennifer L. Troyer, Hermann Sorgho, Oyedunni Arulogun, Ravnit Grewal, Bongani M. Mayosi, Jacob Plange-Rhule, Christiane Hertz-Fowler, Alia Benkahla, Okechukwu S Ogah, Akin Abayomi, Mayowa O. Owolabi, Mark E Engel, Rufus Akinyemi, Ezekiel Adebiyi, Alash'le Abimiku, John Chisi, Patricia A. Marshall, Bruce Ovbiagele, Catherine Kyobutungi, Ambroise Wonkam, Vincent Tukei, David T. Burke, Fred Stephen Sarfo, Andrew Owen, Julie Makani, Leslie Derr, Mary Claire King, Nicki Tiffin, Vincent Boima, Barrington G. Burnett, Martin Simuunza, Christine Beiswanger, Nicola Mulder, Ekaete Tobin, Katherine Littler, Frank C. Brosius, Rulan S. Parekh, Halidou Tinto, Talishiea Croxton, Onikepe A. Folarin, Seydou Doumbia, Parham Goesbeck, Salina P. Waddy, Andrew Brooks, Marva Moxey-Mims, Guida Landouré, Marie Sarr, Martin R. Pollak, Akinlolu O. Ojo, Danny Asogun, Beverley van Rooyen, Clement Adebamowo, Jeanne F. Loring, Naomi S. Levitt, Jonathan K. Kayondo, Nadia Carstens, John V. Moran, F. Xavier Gómez-Olivé, John Musuku, Enock Matovu, Ifeoma Ulasi, Alisha N. Wade, Regina James, Ebony B. Madden, Liam Smeeth, Friedhelm Hilderbrandt, James Brandful, Chisomo L. Msefula, Christopher Hugo-Hamman, Annette MacLeod, Lara Bethke, Judit Kumuthini, Julia Puzak, Mengistu Tadase Yewondwossen, Sudha Srinivasan, Sheik Humarr Khan, Daniel K. Masiga, Mathurin Koffi, Oathokwa Nkomazana, Sununguko Wata Mpoloka, Fatiu A Arogundade, Dissou Affolabi, Ahmed M. Alzohairy, Ayesha A. Motala, Pan Pan Jiang, Adebowale D. Ademola, Ana Olga Mocumbi, Samuel Kyobe, Graeme Mardon, Albert Akpalu, Karen A. Lacourciere, Himla Soodyall, Branwen J. Hennig, Bruno Bucheton, Naby Balde, Michael Mate-Kole, Alexander K. Nyarko, Helen McIlleron, Mary Lynn Baniecki, Ivy Ekem, Corrine Merle, Rasheed Gbadegesin, Junaid Gamieldien, Makerere University [Kampala, Ouganda] (MAK), Institut de Recherche pour le Développement (IRD), University of Malawi, University of Liverpool, Université Jean Lorougnon Guédé (UJloG ), University of Glasgow, Institut National de Recherche Biomédicale [Kinshasa] (INRB), Centre international de recherche-développement sur l'élevage en zone sub-humide (CIRDES), Université de Dschang, University of Zambia [Lusaka] (UNZA), University of Cape Town, University of Nairobi (UoN), Instituto Nacional de Saude [Maputo, Mozambique] (INS), Windhoek Central Hospital [Namibie], University College Hospital [Ibadan, Nigeria], Alzaiem Alazhari University [Soudan] (AAU-Sudan), Mulago Hospital [Kampala, Ouganda], Newcastle University [Newcastle], McMaster University [Hamilton, Ontario], University of Manchester [Manchester], Nelson R Mandela School of Medicine [Durban, South Africa] (NRMSM), University of KwaZulu-Natal (UKZN), University of Yaoundé [Cameroun], Medical Research Council Unit The Gambia (MRC), Hôpital Donka, Ministère de la Santé [Conakry, Guinea], Malawi Liverpool Wellcome Trust Clinical Research Programme (MLW), Liverpool School of Tropical Medicine (LSTM)-University of Liverpool-Wellcome Trust-University of Malawi, University of Nigeria, Institute of Human Virology [Nigeria] (IHVN), National Institute for Medical Research [Tanzania] (NIMR), MRC/UVRI & LSHTM Uganda Research Unit, Medical Research Council-London School of Hygiene and Tropical Medicine (LSHTM)-Medical Research Council Unit The Gambia (MRC)-Uganda Virus Research Institute (UVRI), The Wellcome Trust Sanger Institute [Cambridge], London School of Hygiene and Tropical Medicine (LSHTM), Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford [Oxford], The Wellcome Trust Centre for Human Genetics [Oxford], National Human Genome Research Institute (NHGRI), Institut Pasteur de Tunis, and Réseau International des Instituts Pasteur (RIIP)

Subjects
MESH: Health, [SDV]Life Sciences [q-bio], MEDLINE, Genomics, Genome-wide association study, Computational biology, Biology, MESH: Africa, 03 medical and health sciences, 0302 clinical medicine, MESH: England, Research capacity, MESH: Disease/genetics, MESH: United States, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, Multidisciplinary, MESH: Humans, business.industry, MESH: Genomics/trends, Biotechnology, MESH: Genome-Wide Association Study/trends, MESH: Genetics, Medical/trends, business, MESH: National Institutes of Health (U.S.)
Abstract

H3Africa is developing capacity for health-related genomics research in Africa

Published
2014
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24. Research capacity. Enabling the genomic revolution in Africa

Author

Charles, Rotimi, Akin, Abayomi, Alash'le, Abimiku, Victoria May, Adabayeri, Clement, Adebamowo, Ezekiel, Adebiyi, Adebowale D, Ademola, Adebowale, Adeyemo, Dwomoa, Adu, Dissou, Affolabi, Godfred, Agongo, Samuel, Ajayi, Sally, Akarolo-Anthony, Rufus, Akinyemi, Albert, Akpalu, Marianne, Alberts, Orlando, Alonso Betancourt, Ahmed Mansour, Alzohairy, Gobena, Ameni, Olukemi, Amodu, Gabriel, Anabwani, Kristian, Andersen, Fatiu, Arogundade, Oyedunni, Arulogun, Danny, Asogun, Rasheed, Bakare, Naby, Balde, Mary Lynn, Baniecki, Christine, Beiswanger, Alia, Benkahla, Lara, Bethke, Micheal, Boehnke, Vincent, Boima, James, Brandful, Andrew I, Brooks, Frank C, Brosius, Chester, Brown, Bruno, Bucheton, David T, Burke, Barrington G, Burnett, Stacy, Carrington-Lawrence, Nadia, Carstens, John, Chisi, Alan, Christoffels, Richard, Cooper, Heather, Cordell, Nigel, Crowther, Talishiea, Croxton, Jantina, de Vries, Leslie, Derr, Peter, Donkor, Seydou, Doumbia, Audrey, Duncanson, Ivy, Ekem, Ahmed, El Sayed, Mark E, Engel, John C K, Enyaru, Dean, Everett, Faisal M, Fadlelmola, Eyitayo, Fakunle, Kenneth H, Fischbeck, Anne, Fischer, Onikepe, Folarin, Junaid, Gamieldien, Robert F, Garry, Simani, Gaseitsiwe, Rasheed, Gbadegesin, Anita, Ghansah, Maria, Giovanni, Parham, Goesbeck, F Xavier, Gomez-Olive, Donald S, Grant, Ravnit, Grewal, Mark, Guyer, Neil A, Hanchard, Christian T, Happi, Scott, Hazelhurst, Branwen J, Hennig, Christiane, Hertz, Fowler, Winston, Hide, Friedhelm, Hilderbrandt, Christopher, Hugo-Hamman, Muntaser E, Ibrahim, Regina, James, Yasmina, Jaufeerally-Fakim, Carolyn, Jenkins, Ute, Jentsch, Pan-Pan, Jiang, Moses, Joloba, Victor, Jongeneel, Fourie, Joubert, Mukthar, Kader, Kathleen, Kahn, Pontiano, Kaleebu, Saidi H, Kapiga, Samar Kamal, Kassim, Ishmael, Kasvosve, Jonathan, Kayondo, Bernard, Keavney, Adeodata, Kekitiinwa, Sheik Humarr, Khan, Paul, Kimmel, Mary-Claire, King, Robert, Kleta, Mathurin, Koffi, Jeffrey, Kopp, Matthias, Kretzler, Judit, Kumuthini, Samuel, Kyobe, Catherine, Kyobutungi, Daniel T, Lackland, Karen A, Lacourciere, Guida, Landouré, Rita, Lawlor, Thomas, Lehner, Maia, Lesosky, Naomi, Levitt, Katherine, Littler, Zane, Lombard, Jeanne F, Loring, Sylvester, Lyantagaye, Annette, Macleod, Ebony B, Madden, Chengetai R, Mahomva, Julie, Makani, Manmak, Mamven, Marape, Marape, Graeme, Mardon, Patricia, Marshall, Darren P, Martin, Daniel, Masiga, Robin, Mason, Michael, Mate-Kole, Enock, Matovu, Mary, Mayige, Bongani M, Mayosi, Jean Claude, Mbanya, Sheryl A, McCurdy, Mark I, McCarthy, Helen, McIlleron, S O, Mc'Ligeyo, Corrine, Merle, Ana Olga, Mocumbi, Charles, Mondo, John V, Moran, Ayesha, Motala, Marva, Moxey-Mims, Wata Sununguko, Mpoloka, Chisomo L, Msefula, Thuli, Mthiyane, Nicola, Mulder, Gebregziab her, Mulugeta, Dieuodonne, Mumba, John, Musuku, Mo, Nagdee, Oyekanmi, Nash, Daouda, Ndiaye, Anh Quynh, Nguyen, Mark, Nicol, Oathokwa, Nkomazana, Shane, Norris, Betty, Nsangi, Alexander, Nyarko, Moffat, Nyirenda, Eileen, Obe, Reginald, Obiakor, Abraham, Oduro, Solomon F, Ofori-Acquah, Okechukwu, Ogah, Stephen, Ogendo, Kwaku, Ohene-Frempong, Akinlolu, Ojo, Timothy, Olanrewaju, John, Oli, Charlotte, Osafo, Odile, Ouwe Missi Oukem-Boyer, Bruce, Ovbiagele, Andrew, Owen, Mayowa Ojo, Owolabi, Lukman, Owolabi, Ellis, Owusu-Dabo, Guillaume, Pare, Rulan, Parekh, Hugh G, Patterton, Margaret B, Penno, Jane, Peterson, Rembert, Pieper, Jacob, Plange-Rhule, Martin, Pollak, Julia, Puzak, Rajkumar S, Ramesar, Michele, Ramsay, Rebekah, Rasooly, Shiksha, Reddy, Pardis C, Sabeti, Kwamena, Sagoe, Tunde, Salako, Oumar, Samassékou, Manjinder S, Sandhu, Osman, Sankoh, Fred Stephen, Sarfo, Marie, Sarr, Gasnat, Shaboodien, Issa, Sidibe, Gustave, Simo, Martin, Simuunza, Liam, Smeeth, Eugene, Sobngwi, Himla, Soodyall, Hermann, Sorgho, Oumou, Sow Bah, Sudha, Srinivasan, Dan J, Stein, Ezra S, Susser, Carmen, Swanepoel, Godfred, Tangwa, Andrew, Tareila, Ozlem, Tastan Bishop, Bamidele, Tayo, Nicki, Tiffin, Halidou, Tinto, Ekaete, Tobin, Stephen Meir, Tollman, Mahamadou, Traoré, Marsha J, Treadwell, Jennifer, Troyer, Masego, Tsimako-Johnstone, Vincent, Tukei, Ifeoma, Ulasi, Nzovu, Ulenga, Beverley, van Rooyen, Ablo Prudence, Wachinou, Salina P, Waddy, Alisha, Wade, Misaki, Wayengera, James, Whitworth, Louise, Wideroff, Cheryl A, Winkler, Sarah, Winnicki, Ambroise, Wonkam, Mengistu, Yewondwos, Tadase, sen, Nathan, Yozwiak, and Heather, Zar

Subjects
Genetics, Medical, Genomics, Article, United States, England, National Institutes of Health (U.S.), Health, Medical, Africa, Genetics, Humans, Disease, Genome-Wide Association Study
Published
2014

25. Assessing the Quality of the DNA Sequence from The Human Genome Project

Author

Adam Felsenfeld, Jane Peterson, Jeffery A. Schloss, and Mark S. Guyer

Subjects
Genetics, Whole genome sequencing, Contig, Human genome, Genome project, Computational biology, Biology, ENCODE, Genome, Genetics (clinical), DNA sequencing, Sequence (medicine)
Abstract

It is sometimes hard to remember that the first DNA sequence of the entire genome of a free-living organism, Hemophilus influenzae, was reported 17 other prokaryotes (http://linkage.rockefeller. edu/wli/seq/), a unicellular eukaryote, Saccharomyces cerevisiae (Nature 1996), and a multicellular organism, Caenorhabditis elegans (The C. elegans Sequencing Consortium 1998), have been completely sequenced. Progress toward determination of the human DNA sequence has also become more rapid; at the time of this writing, the public databases contain 227.2 Mb of nonredundant, finished sequence available in contigs of >30 kb (and another 152.7 Mb of unfinished sequence) (http:// www.ncbi.nlm.nih.gov/genome/seq/ weekly_report.html). In comparison, there was 84.4 Mb of finished data (http://www.ebi.ac.uk/∼sterk/genomeMOT/) in February 1998. It is increasingly likely that the human sequence will be complete by 2003, and a working draft will be in hand even sooner (Collins et al. 1998; Venter et al. 1998). One consequence of our increased sequencing capacity is that within the next couple of years, we expect the rate of deposition of sequence data to increase from the current ∼3 Mb per week, to an average of well over 10 Mb per week worldwide. Very few scientific fields can measure progress as easily as can be done for large-scale genomic sequencing, quantifiable as it is into base pairs per unit time. However, mere numbers can be deceptive—the essential ‘‘production’’ nature of large-scale genomic sequencing leaves it susceptible to errors in ways other scientific endeavors are not. Because of the rapid accumulation of human genomic sequence data, there is little opportunity for, or even possibility of, direct peer review of data prior to publication. The major venue for primary publication of genomic data is not the peer-reviewed literature at all, but public databases. This is appropriate: Current peer-reviewed biological journals could not handle this much primary data, nor would they want to, nor would the community be likely to entrust this resource only to the printed medium. But more critically, the community has made the important decision that these data must be accessible very rapidly. For publicly funded laboratories throughout the world, genome sequence data are supposed to be released into a public database within 24 hr of being generated (Collins et al. 1998), a standard that is, as far as we are aware, unmatched by any other scientific discipline. This rapid release is in many ways at odds with what is normally understood to be peer review. Finally, the bulk of the work will probably not be directly replicated, especially for the human sequence and that of other large genomes. There is little doubt, however, that the data will be heavily relied on. For all of these reasons, it is important that the Human Genome Project (HGP) devise a way of measuring and reporting the quality of sequence data deposited in the public databases.

Published
1999
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26. The Natufian hunting conundrum: spears, atlatls, or bows? musculoskeletal and armature evidence

Author

Jane Peterson

Subjects
Prehistory, Archeology, Southern Levant, Anthropology, Palestine, Ligament attachment, Biology, Bow and arrow, Archaeology, Hunter-gatherer, Throwing, Demography
Abstract

Research efforts to identify, measure, and interpret musculoskeletal stress markers (MSM) provide data which have utility as independent tests of archaeological hypotheses. The purpose of this paper is to examine MSM from the upper appendicular skeletal elements of prehistoric hunter gatherer groups in the southern Levant of southwest Asia to investigate what forms of weapon technology were being used. Examination of 72 Natufian (12 500–10 000 B.P.) individuals from sites in Jordan and Palestine comprise the skeletal data set. Observations and ordinal measures of the grade and type of MSM reflect higher functional demands and pronounced right side asymmetry among Natufian males. Among the 22 muscle and ligament attachment sites examined, males scored consistently higher, significantly so, with respect to a suite of synergistic muscles that are associated with overhand throwing motions. While this evidence does not preclude the use of bow and arrow technology during the Natufian, it does suggest that hand- and atlatl-delivered projectiles may have continued to play an important role in hunting activities. © 1998 John Wiley & Sons, Ltd.

Published
1998
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27. African-American families with chronically Ill children: Oversights and insights

Author

DeLois P. Weekes, Jane Peterson, and Yvonne M. Sterling

Subjects
African american, medicine.medical_specialty, business.industry, Anemia, Sickle Cell, Pediatrics, United States, Black or African American, Chronic Disease, Humans, Medicine, Family, Health Services Research, Child, business, Psychiatry, Nursing Assessment
Abstract

From a critical review of the literature concerning African-American families' management and care of children having chronic illness, we concluded that information on culture-related experiences in such families remains seriously deficient. To present an accurate picture of African-American life as these families manage a child with a chronic illness, more comprehensive and detailed descriptions of family caregiving styles and other experiences are needed.

Published
1997
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28. The Social and Economic Contexts of Lithic Procurement: Obsidian from Classic-Period Hohokam Sites

Author

Jane Peterson, Douglas R. Mitchell, Shackley, and M. Steven

Subjects
010506 paleontology, Archeology, History, 060102 archaeology, business.industry, media_common.quotation_subject, Museology, Distribution (economics), 06 humanities and the arts, 01 natural sciences, Archaeology, Variety (cybernetics), Procurement, Arts and Humanities (miscellaneous), Elite, 0601 history and archaeology, Economic organization, Economic geography, Sociology, business, Period (music), 0105 earth and related environmental sciences, Diversity (politics), media_common
Abstract

The social and economic organization of obsidian procurement has been a topic of particular interest in southwestern archaeology as a result of recent work identifying and characterizing a number of sources throughout Arizona, New Mexico, and northern Mexico. Recent studies have attempted to explain temporal and spatial variability of obsidian distribution in the larger contexts of regional exchange networks, socially bounded territories, and elite redistributive efforts. This study reviews the current state of research as reflected in three models. Patterns in obsidian source diversity and reduction stage data are assessed relative to model expectations and an analysis of obsidian acquisition and distribution. The likelihood of elite members of an increasingly formalized socioeconomic system playing a role in these processes should be considered, while at the same time noting that kin-based raw material procurement and ritual item mobilization may explain many of the obsidian patterns. The emerging perspective suggests that obsidian moved in a variety of spheres, concurrently serving a number of social and economic purposes. This study highlights the importance of modeling individual, nonlocal commodities before attempting to generate monolithic exchange models.

Published
1997
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29. Comprehensive genomic characterization of squamous cell lung cancers

Author

Charles J. Vaske, Ying Du, Theodore C. Goldstein, Ping Yang, Yufeng Liu, Bryan Hernandez, Daniel R. Zerbino, Kenneth H. Buetow, Khurram Z. Khan, Semin Lee, Martin Peifer, Kristin G. Ardlie, James G. Herman, Sanja Dacic, Ashley Hill, Christopher Szeto, Jianjiong Gao, Singer Ma, Peng Chieh Chen, Carl F. Schaefer, David G. Beer, Kerstin David, Brent W. Zanke, Karen Mungall, Beverly Lee, Daniel DiCara, Kristen Rogers, Rui Jing, Christina Liquori, Carrie Sougnez, Ron Bose, Brian O'Connor, Piotr A. Mieczkowski, Scott L. Carter, Andy Chu, Peter W. Laird, David J. Kwiatkowski, R. Craig Cason, Marie Christine Aubry, Rileen Sinha, Dennis T. Maglinte, Chad J. Creighton, Howard H. Sussman, Jill M. Siegfried, Laura A.L. Dillon, Agnes Viale, Marco A. Marra, Stephen E. Schumacher, Dennis A. Wigle, Yongjun Zhao, Robert C. Onofrio, Heidi J. Sofia, Ranabir Guin, Lori Boice, Ling Li, Mark Backus, Pei Lin, Prachi Kothiyal, Jan F. Prins, Lauren Averett Byers, Haiyan I. Li, An He, Ka Ming Nip, Chang-Jiun Wu, Peter Dolina, James A. Robinson, Saianand Balu, Collisson E, Jinze Liu, Nicholas D. Socci, Erin Pleasance, Joan Pontius, Christina Yau, Eric E. Snyder, Shaowu Meng, Mei Huang, Aaron McKenna, Corbin D. Jones, Carl Morrison, Malcolm V. Brock, Chris Wakefield, Jared R. Slobodan, Ethan Cerami, Angela Tam, Jane Peterson, Michael D. Topal, Jacob M. Kaufman, Elena Helman, Richard T. Cheney, Dominik Stoll, Cristiane M. Ida, Dante Trusty, Peter S. Hammerman, Yevgeniy Antipin, D. Neil Hayes, Anders Jacobsen, Anna K. Unruh, Noreen Dhalla, Candace Shelton, Peter Waltman, Chris Sander, Zhining Wang, Derek Y. Chiang, Elizabeth J. Thomson, Vonn Walter, JoEllen Weaver, Elena Nemirovich-Danchenko, Jacqueline E. Schein, Bradley M. Broom, Sandra C. Tomaszek, Peter A. Kigonya, Tod D. Casasent, Ari B. Kahn, Joanne Yi, Kyle Ellrott, John M. S. Bartlett, Payal Sipahimalani, William D. Travis, Douglas Voet, Sean P. Barletta, Elizabeth Chun, J. Todd Auman, Ludmila Danilova, Katherine A. Hoadley, Marcin Imielinski, Ramaswamy Govindan, David P. Carbone, Leigh B. Thorne, David A. Wheeler, Carrie Hirst, Barbara Tabak, Sugy Kodeeswaran, Ijeoma A. Azodo, James Stephen Marron, Michael S. Noble, Jianjua John Zhang, Paul K. Paik, Deepak Srinivasan, Boris Reva, B. Arman Aksoy, Kristian Cibulskis, Douglas B. Flieder, Fei Pan, Daniel J. Weisenberger, Ronglai Shen, Jinhua Zhang, Nils Weinhold, Harman Sekhon, David Van Den Berg, Mark S. Guyer, Robert Penny, Hartmut Juhl, Marc Danie Nazaire, Yiqun Zhang, Eric A. Collisson, Robin J.N. Coope, Tom Bodenheimer, Richard Thorp, Junyuan Wu, Matthew Meyerson, Nguyen Phi Hung, Jerome Myers, Artem Sokolov, Yidi J. Turman, Thomas Muley, Stephen B. Baylin, Anisha Gulabani, A. Gordon Robertson, Lynda Chin, Eric Chuah, Richard Varhol, Margi Sheth, Janae V. Simons, Nils Gehlenborg, Tanja Davidsen, Psalm Haseley, Miruna Balasundaram, Olga Potapova, Spring Yingchun Liu, W. Kimryn Rathmell, Bizhan Bandarchi-Chamkhaleh, Wendy Winckler, David Mallery, Nicholas J. Petrelli, Nicole Todaro, Alex E. Lash, James Shin, Travis Brown, Igor Jurisica, Benjamin Gross, Hailei Zhang, Nikolaus Schultz, Kenna R. Mills Shaw, Nam Pho, William Pao, Darlene Lee, Zhen Fan, Troy Shelton, Yan Shi, Shelley Alonso, Carmelo Gaudioso, Peter B. Illei, Stuart R. Jefferys, Maureen F. Zakowski, Marian Rutledge, Bruce E. Johnson, Andrew J. Mungall, Eric S. Lander, Matthew G. Soloway, Michael Mayo, Christopher G. Maher, John V. Heymach, Lihua Zou, Dominique L. Berton, Nina Thiessen, Gary K. Scott, Anna L. Chu, Richard A. Hajek, Ming-Sound Tsao, Liming Yang, Qianxing Mo, Nguyen Van Bang, Martin Hirst, John Eckman, Erin Curley, Rajiv Dhir, Gad Getz, Stanley Girshik, Xuan Van Le, Jeff Boyd, Roman K. Thomas, Konstantin V. Fedosenko, Juok Cho, Alexei Protopopov, Nguyen Viet Tien, Lixing Yang, Laetitia Borsu, Steven J.M. Jones, Matthew D. Wilkerson, Mark Sherman, Andrew Crenshaw, Doug Voet, Elizabeth Buda, Jennifer Brown, Yaron S.N. Butterfield, Rehan Akbani, Todd Pihl, Ruibin Xi, Nianxiang Zhang, Jessica Walton, Ricardo Ramirez, Lisle E. Mose, Leslie Cope, Greg Eley, Mark A. Jensen, John N. Weinstein, Li Ding, Li-Wei Chang, Matthew C. Nicholls, Peter J. Park, Bui Duc Phu, Christopher R. Cabanski, Bernard Kohl, Julien Baboud, Joseph Paulauskis, David Pot, Gordon Robertson, Jingchun Zhu, John A. Demchok, Eunjung Lee, Giovanni Ciriello, Mary Iacocca, Gordon Saksena, Jesse Walsh, Yupu Liang, William K. Funkhouser, Rashmi N. Sanbhadti, Sam Ng, Venkatraman E. Seshan, Valerie W. Rusch, Robert A. Holt, Robert Sfeir, Jung E. Hye-Chun, Kai Wang, Helga Thorvaldsdottir, Huy V. Nguyen, Christopher Wilks, Brian Craft, Donghui Tan, David Haussler, Charles M. Perou, Timothy J. Triche, Christopher C. Benz, Scot Waring, Peggy Yena, Richard A. Moore, Darshan Singh, Andrew D. Cherniack, Rameen Beroukhim, Michael S. Lawrence, Xiaojia Ren, Stacey Gabriel, Martha Hatfield, Christine Czerwinski, Alan P. Hoyle, Marc Ladanyi, Joshua M. Stuart, Andrey Sivachenko, Jacqueline D. Palchik, Thomas Zeng, Inanc Birol, Rohini Raman, Ijeoma Azodo, Jianhua Zhang, Adam B. Olshen, Bradley A. Ozenberger, Angela Hadjipanayis, Sachet A. Shukla, Barry S. Taylor, John M. Greene, Jill P. Mesirov, Petar Stojanov, Raju Kucherlapati, Richard Corbett, Farhad Kosari, Martin L. Ferguson, Natasha Rekhtman, Keith A. Baggerly, Scott Morris, Brenda Rabeno, Massachusetts Institute of Technology. Department of Biology, Lander, Eric S., and Park, Peter J.

Subjects
Lung Neoplasms, Squamous Differentiation, DNA Mutational Analysis, Adenocarcinoma of Lung, Biology, Adenocarcinoma, Article, Phosphatidylinositol 3-Kinases, Gefitinib, Mutation Rate, CDKN2A, Carcinoma, medicine, Humans, Molecular Targeted Therapy, Lung cancer, Multidisciplinary, Genome, Human, Gene Expression Profiling, Genes, p16, Genomics, medicine.disease, Genes, p53, Gene expression profiling, Gene Expression Regulation, Neoplastic, Mutation, Cancer research, Carcinoma, Squamous Cell, Gene Deletion, medicine.drug, Necitumumab, Signal Transduction
Abstract

Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no molecularly targeted agents have been specifically developed for its treatment. As part of The Cancer Genome Atlas, here we profile 178 lung squamous cell carcinomas to provide a comprehensive landscape of genomic and epigenomic alterations. We show that the tumour type is characterized by complex genomic alterations, with a mean of 360 exonic mutations, 165 genomic rearrangements, and 323 segments of copy number alteration per tumour. We find statistically recurrent mutations in 11 genes, including mutation of TP53 in nearly all specimens. Previously unreported loss-of-function mutations are seen in the HLA-A class I major histocompatibility gene. Significantly altered pathways included NFE2L2 and KEAP1 in 34%, squamous differentiation genes in 44%, phosphatidylinositol-3-OH kinase pathway genes in 47%, and CDKN2A and RB1 in 72% of tumours. We identified a potential therapeutic target in most tumours, offering new avenues of investigation for the treatment of squamous cell lung cancers., National Institutes of Health (U.S.) (Grant U24 CA126561), National Institutes of Health (U.S.) (Grant U24 CA126551), National Institutes of Health (U.S.) (Grant U24 CA126554), National Institutes of Health (U.S.) (Grant U24 CA126543), National Institutes of Health (U.S.) (Grant U24 CA126546), National Institutes of Health (U.S.) (Grant U24 CA126563), National Institutes of Health (U.S.) (Grant U24 CA126544), National Institutes of Health (U.S.) (Grant U24 CA143845), National Institutes of Health (U.S.) (Grant U24 CA143858), National Institutes of Health (U.S.) (Grant U24 CA144025), National Institutes of Health (U.S.) (Grant U24 CA143882), National Institutes of Health (U.S.) (Grant U24 CA143866), National Institutes of Health (U.S.) (Grant U24 CA143867), National Institutes of Health (U.S.) (Grant U24 CA143848), National Institutes of Health (U.S.) (Grant U24 CA143840), National Institutes of Health (U.S.) (Grant U24 CA143835), National Institutes of Health (U.S.) (Grant U24 CA143799), National Institutes of Health (U.S.) (Grant U24 CA143883), National Institutes of Health (U.S.) (Grant U24 CA143843), National Institutes of Health (U.S.) (Grant U54 HG003067), National Institutes of Health (U.S.) (Grant U54 HG003079), National Institutes of Health (U.S.) (Grant U54 HG003273)

Published
2012

31. Structure, function and diversity of the healthy human microbiome

Author

Catherine A. Lozupone, Paul Spicer, Margaret Priest, Todd J. Treangen, Niall J. Lennon, Thomas M. Schmidt, Sandra W. Clifton, Ken Chu, Vandita Joshi, Catherine C. Davis, Omry Koren, Yuanqing Wu, Christie Kovar, Jonathan Friedman, Matthew D. Pearson, Scott T. Kelley, Brandi L. Cantarel, Patrick S. G. Chain, Chad Nusbaum, Jonathan Crabtree, Lu Wang, Bonnie P. Youmans, James A. Katancik, George M. Weinstock, Granger G. Sutton, Lisa Begg, Candace N. Farmer, Victor Felix, Barbara A. Methé, Elena Deych, Martin J. Blaser, Amy L. McGuire, Pamela McInnes, Xiang Qin, James Versalovic, James R. White, Yan Ding, Christian J. Buhay, Jason R. Miller, Susan M. Huse, Wm. Michael Dunne, Vivien Bonazzi, Jeremy Zucker, Ioanna Pagani, Robert C. Edgar, Dana A. Busam, Gina A. Simone, Michael Feldgarden, Vincent Magrini, Richard A. Gibbs, Noam J. Davidovics, Indresh Singh, Lucinda Fulton, Lucia Alvarado, Rob Knight, Emma Allen-Vercoe, Teena Mehta, Patricio S. La Rosa, Carsten Russ, Joshua Orvis, Sahar Abubucker, Jacques Ravel, Richard R. Sharp, Dirk Gevers, Wesley C. Warren, Pamela Sankar, Chad Tomlinson, Donna M. Muzny, Jean E. McEwen, Nihar U. Sheth, Sheila Fisher, Katherine H. Huang, Dennis C. Friedrich, Gary C. Armitage, John Martin, Richard K. Wilson, Katarzyna Wilczek-Boney, Catrina Fronick, Patrick Minx, Rebecca Truty, William D. Shannon, Matthew B. Scholz, Kris A. Wetterstrand, Maria Y. Giovanni, Katherine P. Lemon, Floyd E. Dewhirst, Shaila Chhibba, Anthony A. Fodor, Lan Zhang, Patrick D. Schloss, Lynn M. Schriml, Doyle V. Ward, Diana Tabbaa, Jose C. Clemente, Larry J. Forney, Kimberley D. Delehaunty, Cesar Arze, Sharvari Gujja, Lita M. Proctor, Christopher Smillie, Elizabeth L. Appelbaum, Konstantinos Liolios, Chandri Yandava, David J. Dooling, Emily L. Harris, Katherine S. Pollard, Clinton Howarth, Tatiana A. Vishnivetskaya, Sarah Young, Huaiyang Jiang, Karoline Faust, Janet K. Jansson, Kymberlie Hallsworth-Pepin, Owen White, Thomas J. Sharpton, Yiming Zhu, Yanjiao Zhou, Julia A. Segre, Jason Walker, Heidi H. Kong, Toby Bloom, Mathangi Thiagarajan, Tulin Ayvaz, I. Min A. Chen, Bo Liu, Kim C. Worley, Jennifer R. Wortman, Susan Kinder Haake, Manolito Torralba, Makedonka Mitreva, Kjersti Aagaard, J. Fah Sathirapongsasuti, Carolyn Deal, Jeroen Raes, Olukemi O. Abolude, Yue Liu, Rachel L. Erlich, Gary L. Andersen, Nicola Segata, Christopher Wellington, Todd Wylie, Kristine M. Wylie, Tsegahiwot Belachew, Jonathan H. Badger, Mark A. Watson, Aye Wollam, Zhengyuan Wang, Michelle G. Giglio, Kelvin Li, Diane E. Hoffmann, Cristyn Kells, Daniel D. Sommer, Victor M. Markowitz, Chien Chi Lo, Karen E. Nelson, Brian J. Haas, Ruth M. Farrell, Craig Pohl, Harindra Arachchi, Nicholas B. King, Gregory A. Buck, Konstantinos Mavromatis, Qiandong Zeng, Krishna Palaniappan, Kathie A. Mihindukulasuriya, Dan Knights, Anup Mahurkar, Nathalia Garcia, Mary A. Cutting, Theresa A. Hepburn, Mina Rho, Catherine Jordan, Christina Giblin, Dawn Ciulla, Shital M. Patel, Eric J. Alm, Kevin Riehle, Irene Newsham, Sarah K. Highlander, Jamison McCorrison, Nikos C. Kyrpides, Mircea Podar, Beltran Rodriguez-Mueller, Lora Lewis, Robert S. Fulton, Yuzhen Ye, Joseph L. Campbell, Laurie Zoloth, R. Dwayne Lunsford, Ramana Madupu, A. Scott Durkin, Maria C. Rivera, Sergey Koren, Shibu Yooseph, Ruth E. Ley, Erica Sodergren, Cecil M. Lewis, Heather Huot Creasy, Joseph F. Petrosino, Jacques Izard, Jack D. Sobel, J. Paul Brooks, Jeffrey G. Reid, Antonio Gonzalez, Narmada Shenoy, Elizabeth A. Lobos, Georgia Giannoukos, Matthew C. Ross, Allison D. Griggs, Yu-Hui Rogers, Leslie Foster, Wendy A. Keitel, Lei Chen, Alyxandria M. Schubert, Scott Anderson, Peter J. Mannon, Shane Canon, Hongyu Gao, Mihai Pop, Holli A. Hamilton, Tessa Madden, Michelle Oglaughlin, Karthik Kota, Monika Bihan, Veena Bhonagiri, Michael Holder, Daniel McDonald, Liang Ye, Sandra L. Lee, Rosamond Rhodes, Asif T. Chinwalla, Ashlee M. Earl, Shannon Dugan, Sean Conlan, Johannes B. Goll, Jonathan M. Goldberg, Valentina Di Francesco, Curtis Huttenhower, Brandi Herter, Todd Z. DeSantis, Sean M. Sykes, Michael Fitzgerald, Elaine R. Mardis, Jane Peterson, Bruce W. Birren, Ravi Sanka, Carl C. Baker, Jeffery A. Schloss, Massachusetts Institute of Technology. Computational and Systems Biology Program, Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Civil and Environmental Engineering, Alm, Eric J., Friedman, Jonathan, and Smillie, Christopher S.

Subjects
Adult, Male, Adolescent, Ecology (disciplines), Biology, Bioinformatics, 03 medical and health sciences, Young Adult, RNA, Ribosomal, 16S, Humans, Microbiome, Ecosystem, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Bacteria, 030306 microbiology, Gastrointestinal Microbiome, Human microbiome, Biodiversity, Phenotype, Evolutionary biology, Health, Earth Microbiome Project, Metagenome, Enterotype, Female, Oral Microbiome, Metagenomics, Metabolic Networks and Pathways, Human Microbiome Project
Abstract

Author Manuscript date: 2013 February 05., Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this diversity remains unexplained, although diet, environment, host genetics and early microbial exposure have all been implicated. Accordingly, to characterize the ecology of human-associated microbial communities, the Human Microbiome Project has analysed the largest cohort and set of distinct, clinically relevant body habitats so far. We found the diversity and abundance of each habitat’s signature microbes to vary widely even among healthy subjects, with strong niche specialization both within and among individuals. The project encountered an estimated 81–99% of the genera, enzyme families and community configurations occupied by the healthy Western microbiome. Metagenomic carriage of metabolic pathways was stable among individuals despite variation in community structure, and ethnic/racial background proved to be one of the strongest associations of both pathways and microbes with clinical metadata. These results thus delineate the range of structural and functional configurations normal in the microbial communities of a healthy population, enabling future characterization of the epidemiology, ecology and translational applications of the human microbiome.

Published
2012

32. Comprehensive molecular characterization of human colon and rectal cancer

Author

Donghui Tan, Nils Gehlenborg, Robert S. Fulton, Pat Swanson, Pei Lin, Chang-Jiun Wu, Piotr A. Mieczkowski, David Haussler, Marco A. Marra, Stephen E. Schumacher, Bernard Kohl, Jingchun Zhu, Lucinda Fulton, Charles M. Perou, Timothy J. Triche, Madhumati Gundapuneni, Mark Backus, Eve Shinbrot, Yonghong Xiao, Xuan Van Le, Liming Yang, Gad Getz, Stanley Girshik, Jessica Walton, Barbara Tabak, Greg Eley, Brian O'Connor, Larissa K. Temple, Saianand Balu, Eric A. Collisson, Tanja Davidsen, Elizabeth Buda, Janae V. Simons, Anisha Gulabani, Joseph Willis, Tod D. Casasent, Scott Morris, Doug Voat, Jireh Santibanez, Jennifer Drummond, Li Ding, Nicholas J. Petrelli, Andrew J. Mungall, Michael Mayo, Aaron D. Black, Gerald C. Chu, Elizabeth N. Medina, Huy V. Nguyen, Aaron E. Cozen, Yongjun Zhao, Hui Shen, Christopher Szeto, Brenda Rabeno, Martin Hirst, Bogumil Kaczkowski, Lisle E. Mose, Lora Lewis, Brian Craft, Joseph Paulauskis, Ari B. Kahn, Andy Chu, Peter W. Laird, Benjamin Gross, Matthew D. Wilkerson, Raju Kucherlapati, Matthew C. Nicholls, David Van Den Berg, Vesteinn Thorsson, Richard W. Park, Ethan Cerami, David A. Wheeler, Laura A.L. Dillon, Angela Tam, Julien Baboud, Kim D. Delehaunty, Katherine A. Hoadley, Ranabir Guin, Donna M. Muzny, Gordon Saksena, Shaowu Meng, Richard Kreisberg, Kenneth H. Buetow, Rajiv Dhir, Inanc Birol, Timo Erkkilä, Martin L. Ferguson, Robert A. Holt, Elaine R. Mardis, Aaron McKenna, Rohini Raman, Robert Sfeir, Mark Sherman, Andrew Crenshaw, J. Zachary Sanborn, Spring Yingchun Liu, Yuan Qing Wu, Jane Peterson, Eric E. Snyder, Lisa Iype, John N. Weinstein, Helga Thorvaldsdottir, Adam J. Bass, Dominik Stoll, Brady Bernard, Steven J.M. Jones, Peter Dolina, Julie M. Gastier-Foster, Jared R. Slobodan, Mark A. Jensen, Jacqueline E. Schein, Christie Kovar, Anders Jacobsen, Stephen C. Benz, J. Todd Auman, Juinhua Zhang, Peter Fielding, Paul T. Spellman, Jacqueline D. Palchik, Jay Bowen, Thomas Zeng, Douglas Voet, Arnulf Dörner, Joshua M. Stuart, Ryan Demeter, Theodore C. Goldstein, Keith A. Baggerly, Jorma J. de Ronde, Deepak Srinivasan, Boris Reva, Robert E. Pyatt, Andrew Kaufman, Timothy A. Chan, Alexei Protopopov, William G. Richards, Daniel R. Zerbino, Brenda Ayala, Martin R. Weiser, Psalm Haseley, Margaret Morgan, Mary Iacocca, Thomas Robinson, Chad J. Creighton, Dominique L. Berton, Da Yang, Peng Chieh Chen, Carl F. Schaefer, Peter White, Fred Denstman, Giovanni Ciriello, Matthew N. Bainbridge, Heidi J. Sofia, Irene Newsham, Jill P. Mesirov, Ling Li, Benjamin P. Berman, Daniel J. Weisenberger, Garrett M. Nash, Jason Walker, Nina Thiessen, Narayanan Sathiamoorthy, James A. Robinson, Petar Stojanov, Todd Wylie, Derek Y. Chiang, Kristin G. Ardlie, Jianjiong Gao, Lisa Wise, Bradley A. Ozenberger, Jeffrey G. Reid, Angela Hadjipanayis, Sachet A. Shukla, Barry S. Taylor, John M. Greene, Eric Chuah, Richard Varhol, Lisa R. Trevino, Charles J. Vaske, Ying Du, Arthur P. Goldberg, Rui Jing, Jon Whitmore, Joan Pontius, Yevgeniy Antipin, Kyle Ellrott, Nilsa C. Ramirez, Tom Bodenheimer, Junyuan Wu, Lynda Chin, Scott L. Carter, Hailei Zhang, Ryan Bressler, Adam Norberg, Stacey Gabriel, Martha Hatfield, Jonathan G. Seidman, Corbin D. Jones, Huyen Dinh, D. Neil Hayes, Christine Czerwinski, Gerald R. Fowler, Mark S. Guyer, Robert Penny, Alan P. Hoyle, Hartmut Juhl, Catrina Fronick, Margi Sheth, Christopher C. Benz, Scot Waring, Peggy Yena, Richard A. Moore, Darshan Singh, Toshinori Hinoue, Yaron S.N. Butterfield, Andrew D. Cherniack, Maria C. Mariano, Rameen Beroukhim, Michael S. Lawrence, Xiaojia Ren, Marc Ladanyi, Anna K. Unruh, Noreen Dhalla, Candace Shelton, Gary Witkin, Andrey Sivachenko, David Pot, Michael J. Zinner, Richard Thorp, Jan F. Prins, Eunjung Lee, A. Gordon Robertson, Wendy Winckler, Efsevia Vakiani, Chris Wakefield, Alex H. Ramos, Semin Lee, Zhining Wang, Sam Ng, Lihua Zhou, Christina Liquori, Rileen Sinha, Dennis T. Maglinte, Michael S. Noble, Haiyan I. Li, B. Arman Aksoy, Preethi H. Gunaratne, Michael Meyers, Daniel C. Koboldt, Lawrence A. Donehower, Darlene Lee, Jake Lin, Gary K. Scott, Hye Jung E. Chun, Sheila Reynolds, Anna L. Chu, Rehan Akbani, Todd Pihl, Ruibin Xi, Charles S. Fuchs, Nianxiang Zhang, Stanley R. Hamilton, Bradley M. Broom, Wei Zhang, Chris Sander, Marc Danie Nazaire, Carrie Hirst, Stephen B. Baylin, Joel E. Tepper, Kyle Chang, Miruna Balasundaram, Jen Brown, Yan Shi, Matthew G. Soloway, Richard A. Gibbs, Richard K. Wilson, Peter J. Park, Zhaoshi Zeng, John A. Demchok, Jesse Walsh, Rashmi N. Sanbhadti, Troy Shelton, Lixing Yang, Prachi Kothiyal, Monica M. Bertagnolli, Sean P. Barletta, Kristian Cibulskis, Yidi J. Turman, Nikolaus Schultz, Min Wang, Shelley Alonso, Carsten Zornig, P. Paty, Elizabeth J. Thomson, Peter A. Kigonya, Fei Pan, Yuexin Liu, Matthew Meyerson, Kenna R. Mills Shaw, Nam Pho, Stuart R. Jefferys, Daniel DiCara, Robert C. Onofrio, Erin Pleasance, Eric S. Lander, David J. Dooling, Christina Yau, Michael D. Topal, David B. Solit, Christopher Wilks, Ilya Shmulevich, Robin J.N. Coope, Ronglai Shen, Jose G. Guillem, R. Craig Cason, Massachusetts Institute of Technology. Department of Biology, and Lander, Eric S.

Subjects
DNA Copy Number Variations, Colorectal cancer, Biology, medicine.disease_cause, MLH1, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Mutation Rate, microRNA, medicine, Humans, Exome, 030304 developmental biology, 0303 health sciences, Multidisciplinary, POLD1, Rectal Neoplasms, Gene Expression Profiling, Microsatellite instability, Sequence Analysis, DNA, DNA Methylation, medicine.disease, 3. Good health, 030220 oncology & carcinogenesis, DNA methylation, Colonic Neoplasms, Mutation, Cancer research, KRAS
Abstract

To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples, analysing exome sequence, DNA copy number, promoter methylation and messenger RNA and microRNA expression. A subset of these samples (97) underwent low-depth-of-coverage whole-genome sequencing. In total, 16% of colorectal carcinomas were found to be hypermutated: three-quarters of these had the expected high microsatellite instability, usually with hypermethylation and MLH1 silencing, and one-quarter had somatic mismatch-repair gene and polymerase ε (POLE) mutations. Excluding the hypermutated cancers, colon and rectum cancers were found to have considerably similar patterns of genomic alteration. Twenty-four genes were significantly mutated, and in addition to the expected APC, TP53, SMAD4, PIK3CA and KRAS mutations, we found frequent mutations in ARID1A, SOX9 and FAM123B. Recurrent copy-number alterations include potentially drug-targetable amplifications of ERBB2 and newly discovered amplification of IGF2. Recurrent chromosomal translocations include the fusion of NAV2 and WNT pathway member TCF7L1. Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression., National Institutes of Health (U.S.) (Grant U24CA143799), National Institutes of Health (U.S.) (Grant U24CA143835), National Institutes of Health (U.S.) (Grant U24CA143840), National Institutes of Health (U.S.) (Grant U24CA143843), National Institutes of Health (U.S.) (Grant U24CA143845), National Institutes of Health (U.S.) (Grant U24CA143848), National Institutes of Health (U.S.) (Grant U24CA143858), National Institutes of Health (U.S.) (Grant U24CA143866), National Institutes of Health (U.S.) (Grant U24CA143867), National Institutes of Health (U.S.) (Grant U24CA143882), National Institutes of Health (U.S.) (Grant U24CA143883), National Institutes of Health (U.S.) (Grant U24CA144025), National Institutes of Health (U.S.) (Grant U54HG003067), National Institutes of Health (U.S.) (Grant U54HG003079), National Institutes of Health (U.S.) (Grant U54HG003273)

Published
2011

33. Decreasing pressure ulcers across a healthcare system: moving beneath the tip of the iceberg

Author

Jane Peterson, Mary Zink, and Sue Sendelbach

Subjects
Program evaluation, Family education, Leadership and Management, Minnesota, Point-of-Care Systems, Psychological intervention, Nursing Staff, Hospital, Professional Staff Committees, Translational Research, Biomedical, Education, Nursing, Continuing, Cost of Illness, Patient Education as Topic, Cost Savings, Cost of illness, Medicine, Interprofessional teamwork, Electronic Health Records, Humans, Pressure Ulcer, Multi-Institutional Systems, business.industry, General Medicine, medicine.disease, Skin Care, Cost savings, Nursing Administration Research, Nursing Evaluation Research, Practice Guidelines as Topic, Pressure Ulcer Prevention, Medical emergency, business, Algorithms, Healthcare system, Program Evaluation
Abstract

The authors describe a pressure ulcer prevention program implemented across a large healthcare system in Minnesota. An interprofessional team of representatives from 10 hospitals developed a bundle of interventions directed at measurement standardization, provider education, patient/family education and point-of-care resources for providers, timely nutritional assessment, and a novel Skin Day event intended to increase awareness. The number of pressure ulcers reported to the State of Minnesota decreased 33% after implementation of the program with a potential cost savings of up to $430,000.

Published
2011

34. The 'Minimum Information about an ENvironmental Sequence' (MIENS) specification

Author

Pelin Yilmaz, Renzo Kottmann, Dawn Field, Rob Knight, James R. Cole, Linda Amaral-Zettler, Jack A. Gilbert, Ilene Karsch-Mizrachi, Anjanette Johnston, Guy Cochrane, Robert Vaughan, Christopher Hunter, Joonhong Park, Norman Morrison, Phillipe Rocca-Serra, Peter Sterk, Mani Arumugam, Laura Baumgartner, Bruce W. Birren, Martin J. Blaser, Vivien Bonazzi, Peer Bork, Pier Luigi Buttigieg, Patrick Chain, Elizabeth K. Costello, Heather Huot-Creasy, Peter Dawyndt, Todd DeSantis, Noah Fierer, Jed Fuhrman, Rachel E. Gallery, Richard A. Gibbs, Michelle Gwinn Giglio, Inigo San Gil, Elizabeth M. Glass, Antonio Gonzalez, Jeffrey I. Gordon, Robert Guralnick, Wolfgang Hankeln, Sarah Highlander, Philip Hugenholtz, Janet Jansson, Jerry Kennedy, Dan Knights, Omry Koren, Justin Kuczynski, Nikos Kyrpides, Robert Larsen, Christian L. Lauber, Teresa Legg, Ruth E. Ley, Catherine A. Lozupone, Wolfgang Ludwig, Donna Lyons, Eamonn Maguire, Barbara A. Methé, Folker Meyer, Sara Nakielny, Karen E. Nelson, Diana Nemergut, Josh D. Neufeld, Norman R. Pace, Giriprakash Palanisamy, Jörg Peplies, Jane Peterson, Joseph Petrosino, Lita Proctor, Jeroen Raes, Sujeevan Ratnasingham, Jacques Ravel, David A. Relman, Susanna Assunta-Sansone, Lynn Schriml, Erica Sodergren, Aymé Spor, Jesse Stombaugh, James M. Tiedje, Doyle V. Ward, George M. Weinstock, Doug Wendel, Owen White, Andreas Wilke, Jennifer Wortmann, and Frank Oliver Glöckner

Subjects
Ecology, Bioinformatics, Earth & Environment, Data Standards, Genetics & Genomics, Microbiology, Biotechnology
Abstract

We present the Genomic Standards Consortium’s (GSC) “Minimum Information about an ENvironmental Sequence” (MIENS) standard for describing marker genes. Adoption of MIENS will enhance our ability to analyze natural genetic diversity across the Tree of Life as it is currently being documented by massive DNA sequencing efforts from myriad ecosystems in our ever-changing biosphere.

Published
2010
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35. The 'Minimum Information about an ENvironmental Sequence' (MIENS) specification

Author

Frank Oliver Glöckner, Pelin Yilmaz, Renzo Kottmann, Dawn Field, Rob Knight, James Cole, Linda Amaral-Zettler, Jack Gilbert, Ilene Karsch-Mizrachi, Anjanette Johnston, Guy Cochrane, Robert Vaughan, Christopher Hunter, Joonhong Park, Norman Morrison, Phillipe Rocca-Serra, Peter Sterk, Mani Arumugam, Laura Baumgartner, Bruce Birren, Martin Blaser, Vivien Bonazzi, Peer Bork, Pier Luigi Buttigieg, Patrick Chain, Elizabeth Costello, Heather Huot-Creasy, Peter Dawyndt, Todd DeSantis, Noah Fierer, Jed Fuhrman, Rachel Gallery, Richard Gibbs, Michelle Gwinn Giglio, Inigo San Gil, Elizabeth Glass, Antonio Gonzalez, Jeffrey Gordon, Robert Guralnick, Wolfgang Hankeln, Sarah Highlander, Philip Hugenholtz, Janet Jansson, Jerry Kennedy, Dan Knights, Omry Koren, Justin Kuczynski, Nikos Kyrpides, Robert Larsen, Christian Lauber, Teresa Legg, Ruth Ley, Catherine Lozupone, Wolfgang Ludwig, Donna Lyons, Eamonn Maguire, Barbara Methé, Folker Meyer, Sara Nakielny, Karen Nelson, Diana Nemergut, Josh Neufeld, Norman Pace, Giriprakash Palanisamy, Jörg Peplies, Jane Peterson, Joseph Petrosino, Lita Proctor, Jeroen Raes, Sujeevan Ratnasingham, Jacques Ravel, David Relman, Susanna Assunta-Sansone, Lynn Schriml, Erica Sodergren, Aymé Spor, Jesse Stombaugh, James Tiedje, Doyle Ward, George Weinstock, Doug Wendel, Owen White, Andreas Wilke, and Jennifer Wortmann

Subjects
General Materials Science
Published
2010
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36. Multiple approaches to the treatment of violent couples

Author

Jane Peterson Jennings and Jerry L. Jennings

Subjects
Clinical Psychology, Modalities, Psychotherapist, Social Psychology, Order (business), Psychology
Abstract

The first step in treating violent couples is to determine which of the three basic approaches is most suitable for the client: unilateral (noninteractive treatment of the individual); bilateral (noninteractive treatment of each partner separately); and dyadic (mutual and interactive conjoint treatment). Accurate assessment using defined criteria is absolutely crucial in order to ascertain whether the couple can or cannot be treated together safely. A broad array of established clinical techniques (specific to aggressive couples) can be utilized within each of the three designated modalities. Both assessment criteria and specific clinical techniques are described.

Published
1991
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37. Insights into social insects from the genome of the honeybee Apis mellifera

Author

George M. Weinstock, Andrew K. Jones, Katherine A Aronstein, Irene Gattermeier, Kiyoshi Kimura, Susan E. Fahrbach, Laura I. Decanini, Christina M. Grozinger, Evgeny M. Zdobnov, Susan J. Brown, Jonathan V. Sweedler, Kazutoyo Osoegawa, Christian A. Ross, Joseph J. Gillespie, Ngoc Nguyen, Geert Baggerman, Frank Hauser, Dan Graur, Michelle M. Elekonich, Alison R. Mercer, Amanda F. Svatek, Jean Marie Cornuet, Cornelis J. P. Grimmelikhuijzen, Aleksandar Milosavljevic, Anand Venkatraman, Andrew J. Schroeder, Huaiyang Jiang, Michael R. Kanost, Justin T. Reese, Margaret Morgan, Tomoko Fujiyuki, Kim C. Worley, Susanta K. Behura, Jun Kawai, Robert Kucharski, Gildardo Aquino-Perez, Miguel Corona, Diana E. Wheeler, Kathryn S. Campbell, William M. Gelbart, Amy L. Toth, Yanping Chen, Mira Cohen, Noam Kaplan, Michihira Tagami, Miguel A. Peinado, Peter K. Dearden, Glenford Savery, Liliane Schoofs, Takeo Kubo, Giuseppe Cazzamali, Sylvain Forêt, Thomas C. Newman, Ross Overbeek, Piero Carninci, Ryszard Maleszka, Barbara J. Ruef, Michal Linial, Alexandre S. Cristino, Mary A. Schuler, Huyen Dinh, J. Troy Littleton, Manoj P. Samanta, Waraporn Tongprasit, L. Sian Grametes, Eran Elhaik, Jean-Luc Imler, Zhen Zou, Rodrigo A. Velarde, Tanja Gempe, Dorothea Eisenhardt, Juan Manuel Anzola, Graham J. Thompson, Aaron J. Mackey, René Feyereisen, Mrcia M.G. Bitondi, Lora Lewis, Guy Bloch, Richard A. Gibbs, Jane Peterson, Jay D. Evans, Robert E. Page, Amanda B. Hummon, Viktor Stolc, Donna M. Muzny, Yair Shemesh, Francis M. F. Nunes, Dawn Lopez, Judith H. Willis, Martin Hasselmann, Mark S. Guyer, John G. Oakeshott, Pinglei Zhou, Eriko Kage, Dominique Vautrin, Kevin J. Hackett, Sandra L. Lee, Clay Davis, Christine Emore, Gene E. Robinson, Alexandre Souvorov, T.A. Richmond, Rachel Thorn, Jurgen Huybrechts, Elad B. Rubin, Craig Mizzen, Deborah R. Smith, Walter S. Sheppard, Takekazu Kunieda, Adam Felsenfeld, Bingshan Li, Jeffrey G. Reid, La Ronda Jackson, Jamie J. Cannone, Robin R. Gutell, Jireh Santibanez, Megan J. Wilson, David B. Sattelle, Azusa Kamikouchi, George Miner, Hideaki Takeuchi, Geoffrey Okwuonu, Jennifer Hume, Jonathan Miller, Kazuaki Ohashi, Angela Jovilet, Yoshihide Hayashizaki, Joseph Chacko, Paul Kitts, Erica Sodergren, Charles Hetru, Andrew V. Suarez, Brian P. Lazzaro, Susan E. St. Pierre, Evy Vierstraete, Haobo Jiang, Sandra Hines, Teresa D. Shippy, Greg J. Hunt, Peter Kosarev, Dan Hultmark, Stefan Albert, Susan M. Russo, Chung Li Shu, Michel Solignac, H. Michael G. Lattorff, Xu Ling, Grard Leboulle, Miklós Csürös, Neil D. Tsutsui, Lynne V. Nazareth, Ying Wang, Florence Mougel, Beverly B. Matthews, Kevin L. Childs, Rita A. Wright, Hugh M. Robertson, Lan Zhang, Peter Verleyen, Daniel B. Weaver, Christie Kovar, Chikatoshi Kai, Charles W. Whitfield, Madeline A. Crosby, Natalia V. Milshina, Reed M. Johnson, Michael A. Ewing, Peter L. Jones, Sandra L. Rodriguez-Zas, Michael B. Eisen, Klaus Hartfelder, Karl H.J. Gordon, W. Augustine Dunn, Ling Ling Pu, M. Monnerot, Stephen Richards, Richa Agarwala, Judith Hernandez, Pieter J. de Jong, Michael Williamson, Marcé D. Lorenzen, Zilá Luz Paulino Simões, Mark D. Drapeau, Donna Villasana, Katarína Bíliková, J. Spencer Johnston, David I. Schlipalius, Xuehong Wei, Laurent Duret, Venky N. Iyer, Andrew G. Clark, Christine G. Elsik, Hilary Ranson, Kyle T. Beggs, Mireia Jordà, Shiro Fukuda, Seth A. Ament, Vivek Iyer, Jozef Šimúth, Stewart H. Berlocher, May R. Berenbaum, Robin F. A. Moritz, Tatsuhiko Kadowaki, Charles Claudianos, Gro V. Amdam, Yue Liu, Naoko Sakazume, Morten Schioett, Paul Havlak, Anita M. Collins, Dirk C. de Graaf, Derek Collinge, Ivica Letunic, Carlos H. Lobo, Mizue Morioka, Martin Beye, Rachel Gill, C. Michael Dickens, Daisuke Sasaki, Victor V. Solovyev, Peer Bork, Sunita Biswas, David A. Wheeler, Heidi Paul, Bioinformatique, phylogénie et génomique évolutive (BPGE), Département PEGASE [LBBE] (PEGASE), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Evolution, Génomes et Spéciation (LEGS), Centre National de la Recherche Scientifique (CNRS), and Physical and genetic mapping

Subjects
Male, 0106 biological sciences, Transposable element, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Proteome, Genome, Insect, Molecular Sequence Data, Genes, Insect, Genomics, Biology, 010603 evolutionary biology, 01 natural sciences, Genome, Article, Evolution, Molecular, 03 medical and health sciences, Molecular evolution, Phylogenetics, Animals, Gene, Phylogeny, abeille domestique, 030304 developmental biology, Whole genome sequencing, Genetics, Base Composition, 0303 health sciences, [SDV.GEN]Life Sciences [q-bio]/Genetics, Multidisciplinary, Behavior, Animal, Reproduction, SOCIAL BEHAVIOR, [SDV.BA]Life Sciences [q-bio]/Animal biology, Immunity, APIS MELLIFERA, food and beverages, Bees, Telomere, Physical Chromosome Mapping, INSECTE, Gene Expression Regulation, DNA methylation, DNA Transposable Elements, Female, GENETIQUE DES POPULATIONS, Signal Transduction
Abstract

Ce travail résulte de la collaboration de très nombreux chercheurs. Seuls les auteurs de la rubrique Physical and Genetic Mapping sont cités explicitement.; Here we report the genome sequence of the honeybee Apis mellifera, a key model for social behaviour and essential to global ecology through pollination. Compared with other sequenced insect genomes, the A. mellifera genome has high A1T and CpG contents, lacks major transposon families, evolves more slowly, and is more similar to vertebrates for circadian rhythm, RNA interference and DNA methylation genes, among others. Furthermore, A.mellifera has fewer genes for innate immunity, detoxification enzymes, cuticle-forming proteins and gustatory receptors, more genes for odorant receptors, and novel genes for nectar and pollen utilization, consistent with its ecology and social organization. Compared to Drosophila, genes in early developmental pathways differ in Apis, whereas similarities exist for functions that differ markedly, such as sex determination, brain function and behaviour. Population genetics suggests a novel African origin for the species A.mellifera and insights into whether Africanized bees spread throughout the New World via hybridization or displacement

Published
2006
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38. Genome sequence of the Brown Norway rat yields insights into mammalian evolution

Author

Rui Chen, George M. Weinstock, Cynthia Pfannkoch, Chris P. Ponting, Mark S. Guyer, Manuel L. Gonzalez-Garay, James Taylor, Yixin Chen, Eric D. Green, Simon Cawley, Jo Gullings-Handley, Granger G. Sutton, Jose M. Duarte, Stephen M. J. Searle, Laura Elnitski, Aleksandar Milosavljevic, Alicia Hawes, Stephen C. Mockrin, Oliver Delgado, Shannon Dugan-Rocha, Christine Deramo, Dean Pasko, Marina Alexandersson, Eitan E. Winter, Robert W. Blakesley, Donna Karolchik, Huajun Wang, David Shteynberg, Diane M. Dunn, Carlos López-Otín, Abel Ureta-Vidal, Jia Qian Wu, A. Glodek, Shan Yang, Natasja Wye, Sue Daniels, Keita Geer, Arian F.A. Smit, Jozef Lazar, Pallavi Eswara, Carl Fosler, Douglas Smith, Martin Krzywinski, Uma Mudunuri, George Miner, Herbert Schulz, Angie S. Hinrichs, Manimozhiyan Arumugam, Josep F. Abril, Ursula Vitt, Andrei Volkov, Peter J. Tonellato, Von Bing Yap, Bingshan Li, Jyoti Shetty, Ian Bosdet, Evgeny M. Zdobnov, San Diego Glenn Tesler, Chris Fjell, Yi Zhang, Francis S. Collins, Serafim Batzoglou, Robert Baertsch, Laura Clarke, David Neil Cooper, Carrie Mathewson, Diana L. Kolbe, Kate R. Rosenbloom, Valerie Curwen, Bret A. Payseur, Gerard G. Bouffard, Michael R. Brent, Barbara J. Trask, Scott A. Beatson, Sourav Chatterji, Francisco Camara, Detlev Ganten, Andrew R. Jackson, Claire M. Fraser, Klaus Lindpaintner, Yue Liu, Mark Raymond Adams, Robert A. Holt, Erik Gustafson, Hiram Clawson, Michael L. Metzker, John Douglas Mcpherson, Gregory M. Cooper, Martin S. Taylor, Scott Schwartz, Hui Huang, Darryl Gietzen, Patrick Cahill, Geoffrey Okwuonu, Sandra Hines, J. Craig Venter, Jan Monti, David Steffen, Marco A. Marra, Arnold Kana, Richard D. Emes, Asim Sarosh Siddiqui, Erica Sodergren, Mario Caccamo, Jim Wingrove, Richard R. Copley, Leo Goodstadt, Francesca Chiaromonte, Davinder Virk, Kirt Martin, Colin N. Dewey, Xiang Qin, T. Dan Andrews, K. James Durbin, Michael P. McLeod, Susan Bromberg, Pavel A. Pevzner, Petra Brandt, Austin J. Cooney, Don Jennings, Baoli Zhu, Lynn Doucette-Stamm, Heather Trumbower, Eray Tüzün, Kristian Stevens, Norbert Hubner, Young-Ae Lee, Zhiping Gu, Harold Riethman, Xose S. Puente, Cynthia Sitter, Michael Brudno, Gerald Nyakatura, Oliver Hummel, Caleb Webber, Olivier Couronne, Kim Fechtel, W. J. Kent, Zhengdong D. Zhang, Xing Zhi Song, Matt Weirauch, Ewan Birney, Richard A. Gibbs, William C. Nierman, Anne E. Kwitek, Alexander Poliakov, Mary Barnstead, Jeanette Schmidt, Yanru Ren, Howard J. Jacob, Kateryna D. Makova, Edward M. Rubin, Susan Old, Trixie Nguyen, Arend Sidow, Nicolas Bray, Hong Mei Lee, Lisa M. D'Souza, Heinz Himmelbauer, Cara Woodwark, Peter G. Amanatides, Paul Havlak, Janet M. Young, Eduardo Eyras, Thomas Kreitler, Heming Xing, Sofiya Shatsman, Kushal Chakrabarti, Stephen Rice, Cheryl A. Evans, Kim C. Worley, Peter D. Stenson, Rachel Gill, Pieter J. de Jong, Jacqueline E. Schein, Lior Pachter, Steve Ferriera, Santa Cruz David Haussler, Ross C. Hardison, Holly Baden-Tillson, Margaret Adetobi, Krishna M. Roskin, Guillaume Bourque, Eric A. Stone, Emmanuel Mongin, Michele Clamp, Margaret Morgan, Richard Durbin, Cathy Riemer, Anton Nekrutenko, Mikita Suyama, Soo H. Chin, Kenneth J. Kalafus, Anat Caspi, Donna M. Muzny, Inna Dubchak, Shaying Zhao, Sofyia Abramzon, Michael I. Jensen-Seaman, Steven E. Scherer, Lora Lewis, M. Mar Albà, Terrence S. Furey, Peer Bork, Trevor Woodage, David A. Wheeler, Hans Lehrach, Graham R. Scott, Bin Ma, Paula E. Burch, Robert B. Weiss, Kazutoyo Osoegawa, Evan E. Eichler, Amy Egan, Webb Miller, Cheryl L. Kraft, Steven J.M. Jones, Jeffrey A. Bailey, Roderic Guigó, David Torrents, Heike Zimdahl, Adam Felsenfeld, Jane Peterson, Simon N. Twigger, Claudia Goesele, Keith Weinstock, Minmei Hou, and Zdobnov, Evgeny

Subjects
Male, Models, Molecular, Mammalian Genetics, RNA, Untranslated, Retroelements, Sequence analysis, Gene prediction, Centromere, Genomics, Biology, Regulatory Sequences, Nucleic Acid, Genome, DNA, Mitochondrial, Polymorphism, Single Nucleotide, Rat Genome Database, Evolution, Molecular, Mice, Gene Duplication, Rats, Inbred BN, Animals, Humans, ddc:576.5, Gene, Whole genome sequencing, Genetics, Base Composition, Multidisciplinary, Sequence Analysis, DNA, Telomere, Chromosomes, Mammalian, Introns, Rats, Evolutionary biology, Mutagenesis, DNA Transposable Elements, CpG Islands, RNA Splice Sites
Abstract

The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.

Published
2003

40. Initial sequencing and comparative analysis of the mouse genome

Author

Laura Elnitski, David B. Jaffe, Jia Li, Marina Alexandersson, Michael J. Morgan, Shiaw Pyng Yang, Robert Baertsch, Claire M. Wade, John Tromp, Michael C. Zody, Terrence S. Furey, Emma Overton-Larty, Stephen D. Brown, Scott Schwartz, Diane M. Dunn, J. P. Leger, Kris A. Wetterstrand, David Torrents, Ratna Shownkeen, Brian Schultz, Kim C. Worley, Richard D. Emes, John Mayer, Tom Landers, Beverley Meredith, Carol Scott, R. J. Weber, Sean R. Eddy, David Kulp, Jun Kawai, J Bailey, Fan Hsu, Diana L. Kolbe, Kirsten McLay, Marc Botcherby, Richard Mott, Tracie L. Miner, Jill P. Mesirov, Cristyn Kells, Michael A. Quail, Melanie M. Wall, Alistair G. Rust, Josep F. Abril, Ian F Korf, Peter An, Roderic Guigó, Abel Ureta-Vidal, Evan Mauceli, L. Steven Johnson, Arian F.A. Smit, Arkadiusz Kasprzyk, Michael C. Wendl, Deanna M. Church, Francis S. Collins, Wayne N. Frankel, Pallavi Eswara, Bin Ma, Robert H. Waterston, Stylianos E. Antonarakis, Edward M. Rubin, John Douglas Mcpherson, Andrew Sheridan, Megan McCarthy, Ming Li, Colin N. Dewey, Justin Deri, Rosie Levine, Matthew Jones, Sheila Dodge, Richard R. Copley, Leo Goodstadt, Shan Yang, Donna Maglott, Jamey Wierzbowski, Nick Goldman, Evgeny M. Zdobnov, Simon G. Gregory, C M Clee, Steven Leonard, Elaine R. Mardis, Simon C. Potter, Sarah Sims, Richard A. Gibbs, Mark S. Guyer, Francesca Chiaromonte, Susan Lucas, Mark Diekhans, Steve Searle, Rachel Ainscough, Jane Peterson, Emmanouil T. Dermitzakis, Robert Nicol, Lucy Matthews, Guy Slater, Adam Felsenfeld, Karen Foley, Lucinda Fulton, Tim Hubbard, Richard K. Wilson, Deana W. LaHillier, W. Richard McCombie, Johanna Thompson, Robert David, John Attwood, Anthony P. West, Jane Rogers, Evan Keibler, Lisa Cook, Raju Kucherlapati, Steven Seaman, William E. Nash, Ian J. Jackson, Jonathan Singer, Axin Hua, Tina Graves, Ted Sharpe, Dudley Wyman, Bruce W. Birren, Stuart McLaren, David Willey, A Joy, Douglas Smith, Alexandre Reymond, Paul Flicek, Simon Cawley, Richa Agarwala, Diane Gage, Evanne Trevaskis, Ginger A. Fewell, Michael R. Brent, Tracy C. Ponce, W. James Kent, Timothy Holzer, Eduardo Eyras, Michael J. O’Connor, Webb Miller, Donna M. Muzny, Andrew von Niederhausern, Inna Dubchak, Eitan E. Winter, Catherine Ucla, Arne Stabenau, Michael N. Nhan, Piero Carninci, Michele Clamp, Pavel A. Pevzner, James Meldrim, Tim Cutts, R. D. Campbell, Joy Davies, Wratko Hlavina, Elinor K. Karlsson, David Haussler, John Burton, Peer Bork, Nicole Stange-Thomann, Mikita Suyama, Mark J. Daly, Ewan Birney, Edward J. Kulbokas, Craig Pohl, James C. Mullikin, Chad Nusbaum, Genís Parra, Jade P. Vinson, Yoshihide Hayashizaki, Sante Gnerre, Eric Berry, Daniel G. Brown, Asif T. Chinwalla, Emmanuel Mongin, Robert B. Weiss, Raymond Wheeler, Andrew Kirby, Yasushi Okazaki, Lior Pachter, Ross C. Hardison, Brian Spencer, Carol J. Bult, Joanne O. Nelson, Pankaj K. Agarwal, Darren Grafham, Gustavo Glusman, Thomas A. Jones, Glenn Tesler, Simon Whelan, James Cuff, Robert S. Fulton, K F Barlow, Jörg Schultz, Matthias S. Schwartz, Alex Poliakov, Jonathan Butler, Bruce A. Roe, Angela S. Hinrichs, Alan Coulson, Kate Montgomery, Eric D. Green, Stephan Beck, Val Curwen, Krishna M. Roskin, Robert W. Plumb, Chris P. Ponting, Ralph Santos, Victor Sapojnikov, Nicolas Bray, Kymberlie H. Pepin, Charles W. Sugnet, Olivier Couronne, Ivica Letunic, Sophie Williams, Kimberly D. Delehaunty, Kerstin Lindblad-Toh, Zemin Ning, Karen Oliver, Toby Bloom, Michael Kamal, Nicholas J. Dickens, Eric S. Lander, Christine Lloyd, Donna Karolchik, Adrienne Hunt, Antonarakis, Stylianos, Couronne, Olivier, Dermitzakis, Emmanouil, and Zdobnov, Evgeny

Subjects
RNA, Untranslated, Proteome, Untranslated/genetics, Genome, Transgenic, Repetitive Sequences, Mice, Models, Neoplasms, Conserved Sequence, ddc:616, Genetics, Mice, Knockout, Base Composition, Multidisciplinary, Sex Chromosomes, Pseudogenes/genetics, Genomics, Multigene Family/genetics, Physical Chromosome Mapping, Neoplasms/genetics, CpG Islands/genetics, Proteome/genetics, Genetic Variation/genetics, Multigene Family, Mice/classification/ genetics, Models, Animal, Conserved Sequence/genetics, Sequence Analysis, Pseudogenes, Human, Genome evolution, Evolution, Sequence analysis, Knockout, Quantitative Trait Loci, Mice, Transgenic, Sex Chromosomes/genetics, Computational biology, Biology, Synteny, Chromosomes, Evolution, Molecular, Nucleic Acid/genetics, Genetic, Species Specificity, Mammalian/ genetics, Animals, Humans, Genes/genetics, Selection, Genetic, Selection, Repetitive Sequences, Nucleic Acid, Comparative genomics, Animal, Genome, Human, Molecular, Genetic Variation, DNA, Sequence Analysis, DNA, Chromosomes, Mammalian, Gene Expression Regulation, Genes, Mutagenesis, RNA, Human genome, CpG Islands, Quantitative Trait Loci/genetics, Reference genome
Abstract

The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.

Published
2002

42. Correction: Initial sequencing and analysis of the human genome

Author

Paul Predki, John Sulston, William Morris, Sarah Wenning, Jun Gu, Danielle Thierry-Mieg, Roger A. Schultz, Michael J. Morgan, Michael Doyle, Joseph Szustakowki, Lorenzo Cerutti, A. Coulson, Alex Bateman, Patrick Wincker, Michael C. Zody, Mark T. Ross, Paul G. Richardson, Keri Devon, Yasushi Totoki, Karsten Hokamp, George M. Weinstock, John Howland, Arek Kaspryzk, James G. R. Gilbert, Cher Miranda, Aristides Patrinos, William Saurin, A. Pia Abola, Kazuhiko Kawasaki, John Bouck, Marvin Frazier, Wonhee Jang, Jan Fang Cheng, Stephanie L. Chissoe, Matthew C. Jones, Glen A. Evans, Huanming Yang, Daniel G. Brown, Richard Durbin, Jennifer Baldwin, Tracie L. Miner, Asif T. Chinwalla, Arian F.A. Smit, C M Clee, Elaine R. Mardis, Henning Hermjakob, Nicole Stange-Thomann, Maynard V. Olson, Jian Wang, Cyrus L. Harmon, Shiaw Pyng Yang, André Rosenthal, Catherine Robert, Masahira Hattori, Jane Peterson, Ratna Shownkeen, Maria Athanasiou, Christopher B. Burge, Erica Sodergren, Carrie Sougnez, Lynn Doucette-Stamm, Hidemi Watanabe, Ronald W. Davis, Tarjei S. Mikkelsen, Mark Rosetti, Christopher J. Elkin, Todd M. Lowe, LaDeana W. Hillier, Jane Grimwood, Kazutoyo Osoegawa, Richard R. Copley, Simon Kasif, Joseph J. Catanese, Keith Weinstock, Lee Rowen, Roel Funke, Paul Kitts, Lukas Wagner, Guy Slater, Anne S. Olsen, Edward Uberbacher, Lucinda Fulton, Andrew Dunham, Andrew Heaford, David Kulp, Elbert Branscomb, William Fitzhugh, Eugene V. Koonin, Leroy Hood, Anup Madan, Jean Thierry-Mieg, Richard Reinhardt, Kim C. Worley, Richard M. Myers, Dudley Wyman, Jean Weissenbach, David R. Bentley, Panos Deloukas, Philippe Brottier, H. Blöcker, Stephan Beck, Marc Rubenfield, Terrence S. Furey, Ken Dewar, Michael L. Metzker, Rajinder Kaul, Guyang Huang, Hsiu Chuan Chen, Ewan Birney, Warren Gish, John Douglas Mcpherson, Asao Fujiyama, Aoife McLysaght, Shinsei Minoshima, Sandra W. Clifton, Lisa Kann, R Ainscough, K. Hornischer, Simon G. Gregory, Lauren Linton, Kim D. Delehaunty, James C. Mullikin, Neilay Dedhia, Matthias Platzer, Gerald Nyakatura, John V. Moran, Andrew J. Mungall, Chiharu Kawagoe, François Artiguenave, Deanna M. Church, Elia Stupka, Jun Yu, Peer Bork, Evan E. Eichler, L. Aravind, James H. Gorrell, Bruce A. Roe, Raymond Wheeler, Norman A. Doggett, Douglas R. Smith, Yu Juin Chen, David Haussler, Todd D. Taylor, Stefan Taudien, Susan Lucas, Rebecca Deadman, Hans Lehrach, Hiroaki Shizuya, Doron Lancet, Greg Schuler, Nigel P. Carter, John Burton, Huaqin Pan, Eric S. Lander, Andreas Rump, Nikola Stojanovic, Victor J. Pollara, Alan Williams, Melissa De La Bastide, W. James Kent, Mark S. Guyer, Nicola Mulder, Sarah Milne, Bruce W. Birren, John W. Wallis, Joann Dubois, Tom Slezak, Lisa Cook, Raju Kucherlapati, Andrew Delehaunty, Lucy Matthews, Ian Dunham, L. Steven Johnson, Robert H. Waterston, Andrew Sheridan, Jörg Schultz, Nancy A. Federspiel, Jason B. Kramer, Tim Hubbard, Ru Fang Yeh, Steven E. Scherer, Francis S. Collins, David L. Nelson, Sean Humphray, Tobias Doerks, Chad Nusbaum, Darren Grafham, Mei Lee Hong, Michael Proctor, Christopher K. Raymond, Diane Gage, Kris A. Wetterstrand, Feng Chen, Simon Mercer, Thomas A. Jones, Trevor Hawkins, Aravind Subramanian, Jeffrey A. Bailey, Amanda McMurray, Serafim Batzoglou, Jeremy Schmutz, Jill P. Mesirov, Shizen Qin, Rosie Levine, Adam Felsenfeld, Thomas Brüls, Kevin McKernan, Michele E. Clamp, Christine Lloyd, Susan L. Naylor, Gabriele Nordsiek, Jessica A. Lehoczky, Adrienne Hunt, Marco A. Marra, David R. Cox, Mark Dickson, Michael C. Wendl, Yuri I. Wolf, Jane Rogers, Ian F Korf, Eric Pelletier, Takehiko Itoh, Juliane Ramser, Robert S. Fulton, Sarah Sims, Richard A. Gibbs, Lisa French, Katrina Harris, Richa Agarwala, Christina Raymond, James Meldrim, Sangdun Choi, Richard K. Wilson, Patrick Minx, Douglas L. Johnson, Yoshiyuki Sakaki, Scot Kennedy, Pieter J. de Jong, Yoshihide Hayashizaki, W. Richard McCombie, Sean R. Eddy, Donna M. Muzny, Jerome Naylor, Paul A. McEwan, Atsushi Toyoda, Tetsushi Yada, Nobuyoshi Shimizu, Robert W. Plumb, Catherine M. Rives, Chris P. Ponting, Ralph Santos, Kenneth H. Wolfe, Kymberlie H. Pepin, Roland Heilig, and James E. Galagan

Subjects
Multidisciplinary, Correction, Human genome, Computational biology, Biology
Published
2001
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49. Environmental Education Television Episodes

Author

G. A. Seielstad and Jane Peterson

Subjects
Economic growth, Environmental education, Environmental protection, business.industry, Political science, Public broadcasting, General Earth and Planetary Sciences, business, Global environmental analysis
Abstract

“Our Changing Planet” is a series of 90-second television episodes whose purpose is to enhance public understanding of the global environment and the changes it is undergoing. The hope is that with this deeper understanding, people will appreciate the need to modify behaviors that produce negative environmental effects. The episodes are produced by the Upper Midwest Aerospace Consortium at the University of North Dakota, Grand Forks, with partial funding from NASA. To date, 40 episodes have been created and distributed to 46 public television stations across the United States by the National Educational Telecommunications Association.

Published
2008
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50. Preface

Author

Jane Peterson and Diane E. Hawkey

Subjects
Archeology, Anthropology
Published
1998
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