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Background and purpose: Mortality rate from gastric cancer is growing in the world. Nowadays a very precise relationship exists between the development of cancer and changes in EGF receptor expression levels in many cancers. Probably, one of the best known of these changes is over expression of Her1 and 2 receptors in gastric cancer. This study investigated the expression rate of these two receptors in gastric locally advanced adenocarcinoma, and its correlation with survival of patients Materials and methods: The samples included 130 paraffin blocks obtained from patients with gastric cancer in Imam Khomeini Hospital, Sari 2004-2009. Four micron sections of tissue blocks were prepared and placed on slides. The slides were deparaffinized with xylene and then dehydrated using alcohol. The endogenous peroxidase activity was inhibited. Her2 Antibody was put on the slides and finally, they were stained with hematoxylin. Results: Her1 marker and Her 2 marker were found positive in 23 samples (17.6 %) and in 20 samples (15.4 %), respectively. The simultaneous concomitant of these two markers was also seen in nine patients (6.9 %). In assessing Her2 marker based on sex, from 91 males, only 11 cases (11.6 %) and from 39 females only 9 cases (23 %) were detected positive. Conclusion: By developing the stage of the disease expression level of Her1 marker increased. These findings reveal the diagnostic value of this marker in patients with gastric adenocarcinoma. Probably, the rate of HER1 and HER2 receptors expression is associated with invasion of the disease and survival of the patients. [ABSTRACT FROM AUTHOR]

Background: The Tabari cohort study (TCS), part of the Prospective Epidemiological Research Studies in IrAN (PERSIAN), is a large longitudinal prospective cohort designed to better understand the risk factors associated with major non-communicable diseases (NCDs) across two urban and mountainous regions in north of Iran. Methods: The enrollment phase of TCS started in June 2015 and ended in November 2017. During this phase, individuals aged 35--70 years from urban and mountainous regions of Sari township (Mazandaran province) were invited to the cohort center by health volunteers (urban regions) and Behvarz (mountainous areas) using census information. Data was collected based on the PERSIAN cohort study protocols. Hypertension was defind as systolic blood pressure ≥140 mm Hg or a diastolic blood pressure ≥90 mm Hg or history of diagnosis with hypertension or taking antihypertensive medications among participants free from cardiovascular diseases. Diabetes was defined as fasting blood sugar ≥126 mg/dL or a history of diagnosis or taking glucoselowering medications among all participants. Results: A total of 10,255 participants were enrolled in TCS, 59.5% of whom were female. Among the total population, 7,012 participants were urban residents (68.4%). The prevalence of daily smoking in the total population was 9.1%. Body mass index in 75.9% of participants was ≥25 kg/m². The prevalence of hypertension, diabetes, and thyroid disorders were 22.2%, 17.2%, and 10.5%, respectively. Conclusion: The Tabari cohort is different from other cohorts in terms of levels of risk factors associated with NCDs. This study has certain important strengths including its population-based design and large sample size that provides a valid platform for conducting future investigations and trials. A biobank that has been designed to store blood, nail, hair and urine samples for future research is another strength of this study. Researchers who are interested in using the information can refer to the following web page: http://persiancohort.com. [ABSTRACT FROM AUTHOR]