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357 results on '"Jana, Nihar"'

2. Influence of active, nano, and functionalized zinc oxide particles on the mechanical, cytotoxicity, and thermal stability of carbon black filled SBR/NR blends

Author

Sreethu, T.K., Jana, Sudipta, Jana, Nihar Ranjan, and Naskar, Kinsuk

Subjects
Zinc oxide -- Properties, Nanoparticles -- Properties, Engineering and manufacturing industries, Science and technology
Abstract

This study examines the viability of functionalized, nano, and active zinc oxide (ZnO) as an alternative activator in styrene butadiene rubber-natural rubber (SBR-NR) blends filled with carbon black. Concerns about the environmental impact and toxicity of Zn leaching into aquatic organisms necessitate reducing the amount of ZnO in rubber compounding. The mechanical properties, crosslink density, and thermal and morphological qualities of the SBR/NR blends made with these ZnO (F2BB, N2BB, and A2BB) were studied and compared to conventional ZnO loaded blend (C5BB). Thermal stability was evaluated using thermogravimetric analysis and temperature scanning stress relaxation. A2BB showed the highest thermal stability, while F2BB exhibited a 35% increase in tensile strength and a 28% increase in elongation at break due to polysulfide linkages. N2BB and A2BB increased tensile strength by 28 and 16% compared to C5BB. Cytotoxicity of various ZnO concentrations on HT-22 hippocampal cells was investigated, and active and nano ZnO were found to be less toxic. Using active and nano ZnO can improve the mechanical and thermal properties of the blend while reducing environmental toxicity, allowing for a 60% reduction in ZnO concentration in rubber compounds and resulting in cost savings and a sustainable alternative to conventional ZnO. KEYWORDS activation energy, activator, blends, temperature scanning stress relaxation, ZnO, 1 | INTRODUCTION The most used general-purpose rubbers are styrene butadiene rubber (SBR) and natural rubber (NR), and its blend combination used in various rubber industry applications due to its [...]

Published
2023
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39. Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

Author

Tanaka, Motomasa, Machida, Yoko, Niu, Sanyong, Ikeda, Tetsurou, Jana, Nihar R, Doi, Hiroshi, Kurosawa, Masaru, Nekooki, Munenori, and Nukina, Nobuyuki

Abstract

Inhibition of polyglutamine-induced protein aggregation could provide treatment options for polyglutamine diseases such as Huntington disease. Here we showed through in vitro screening studies that various disaccharides can inhibit polyglutamine-mediated protein aggregation. We also found that various disaccharides reduced polyglutamine aggregates and increased survival in a cellular model of Huntington disease. Oral administration of trehalose, the most effective of these disaccharides, decreased polyglutamine aggregates in cerebrum and liver, improved motor dysfunction and extended lifespan in a transgenic mouse model of Huntington disease. We suggest that these beneficial effects are the result of trehalose binding to expanded polyglutamines and stabilizing the partially unfolded polyglutamine-containing protein. Lack of toxicity and high solubility, coupled with efficacy upon oral administration, make trehalose promising as a therapeutic drug or lead compound for the treatment of polyglutamine diseases. The saccharide-polyglutamine interaction identified here thus provides a new therapeutic strategy for polyglutamine diseases., Author(s): Motomasa Tanaka [1]; Yoko Machida [1]; Sanyong Niu [1]; Tetsurou Ikeda [1]; Nihar R Jana [1]; Hiroshi Doi [1]; Masaru Kurosawa [1]; Munenori Nekooki [1]; Nobuyuki Nukina (corresponding author) [...]

Published
2004
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