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1,064 results on '"Jana, Manisha"'

37. Successful multimodality management of extrarenal extracranial malignant rhabdoid tumour of the left sciatic nerve mimicking a neurofibroma.

Author

Biswas, Ahitagni, Ramdulari, Anjali V., Thakur, Alok, Kumar, Amandeep, G. S., Anju, Jana, Manisha, and Suri, Vaishali

Subjects
NERVE grafting, SCIATIC nerve, CONTRAST-enhanced magnetic resonance imaging, PERIPHERAL nerve tumors, NEUROFIBROMA
Abstract

Extrarenal extracranial malignant rhabdoid tumour (MRT) is a rare and highly aggressive tumour representing <1% of paediatric soft tissue malignancies. Only a few cases of MRT of the thigh arising from the sciatic nerve have been reported in medical literature to date. A 5-year-old girl presented with progressively increasing painless lump in the posterior aspect of the left thigh. A contrast-enhanced magnetic resonance imaging (MRI) of the left thigh showed a 4.7 × 5 × 10.5 cm well-marginated, lobulated, homogeneously enhancing lesion in the posterior compartment of the left thigh along the course of the sciatic nerve. She underwent en bloc excision of the left sciatic nerve tumour and end-to-end anastomosis of the left sciatic nerve with a right sural nerve graft. Histopathological and immunohistochemical examination of the surgical specimen revealed a malignant rhabdoid tumour. INI-1 immunoexpression was lost in the tumour cells. The metastatic workup was essentially normal. Subsequently, she received post-operative radiotherapy to the tumour bed (50.4 Gray in 28 fractions over 5.5 weeks) followed by six cycles of multiagent chemotherapy with ICE (Ifosfamide, Carboplatin, and Etoposide) regimen. On the last follow-up visit, 20 months after surgery, she was in complete clinical and radiological response. Aggressive multimodality management comprising radical resection of tumour, post-operative radiotherapy to the tumour bed, and multiagent chemotherapy with ICE regimen can lead to favourable outcomes in patients with this rare tumour. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Bone in the Brain: Unusual Cause of Intracranial Ossification

Author

Chandola, Stuti and Jana, Manisha

Subjects
Health
Abstract

Byline: Stuti. Chandola, Manisha. Jana A 12-year-old girl with thalassemia major planned for bone marrow transplantation presented with complaints of headache for 1 month and underwent evaluation with a non-contrast [...]

Published
2023

43. Spaghetti in a Hand: Unusual Nerve Pathology in a Child

Author

Jain, Rupali and Jana, Manisha

Subjects
Nervous system tumors -- Case studies -- Diagnosis, Tumors in children -- Case studies -- Diagnosis, Hamartoma -- Case studies -- Diagnosis, Pediatric research, Health
Abstract

Byline: Rupali. Jain, Manisha. Jana A six-year-old boy presented with gradually increasing painless swelling over the left wrist and forearm. Ultrasound revealed fusiform enlargement of the left median nerve, with [...]

Published
2023

50. Pediatric Behçet's disease masquerading as pulmonary malignancy.

Author

Chandola, Stuti, Chopra, Karan, Chawla, Rohan, Azad, Shorya Vardhan, Jana, Manisha, and Bagri, Narendra Kumar

Subjects
BEHCET'S disease, MUCOCUTANEOUS lymph node syndrome, JUVENILE diseases, NOSOLOGY, LUNG diseases, TAKAYASU arteritis, CARDIOVASCULAR system
Abstract

This article discusses a case of pediatric Behçet's disease in an 11-year-old boy who initially presented with symptoms that mimicked pulmonary malignancy. The boy had a paravertebral mass, along with pyrexia of unknown origin, weight loss, myalgias, and orogenital ulcers. Further examination and imaging revealed thrombophlebitis, anemia, leukocytosis, and raised inflammatory markers. After ruling out other conditions, the boy was diagnosed with Behçet's disease based on the pediatric Behçet's criteria. Treatment with medication resulted in improvement, and the boy is currently doing well. The article also provides information on the pulmonary manifestations of Behçet's disease. [Extracted from the article]

Published
2024
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