1. Aberrant expression of the microtubule-associated protein tau is an independent prognostic feature in prostate cancer
- Author
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Cornelia Schroeder, Jan Grell, Claudia Hube-Magg, Martina Kluth, Dagmar Lang, Ronald Simon, Doris Höflmayer, Sarah Minner, Eike Burandt, Till S. Clauditz, Franziska Büscheck, Frank Jacobsen, Hartwig Huland, Markus Graefen, Thorsten Schlomm, Guido Sauter, and Stefan Steurer
- Subjects
MAPT ,Tau ,ERG ,PTEN ,Deletion ,Prostate cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Microtubule-associated protein Tau (MAPT) overexpression has been linked to poor prognosis and decreased response to taxane-based therapies in several cancer types, but its relevance in prostate cancer is unknown. Methods In this study, MAPT expression was analyzed by immunohistochemistry on a tissue microarray containing 17,747 prostate cancers. Results MAPT was absent in normal prostate epithelial cells but detectable in 1004 (8.2%) of 12,313 interpretable cancers. Its expression was associated with advanced tumor stage, high Gleason grade, positive lymph nodes, and early biochemical recurrence (p
- Published
- 2019
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