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Introduction: An increase in appetite and lack of enough movement accelerates the process of contracting chronic diseases, including diabetes, so the present study was conducted with aim to investigate the effect of 12 weeks of Pilates exercises on ghrelin serum levels and appetite in women with type 2 diabetes.Methods: This experimental study was conducted on women with type 2 diabetes (from the Najafabad Diabetes Association) with an age range of 35 to 55 years in Najafabad city. People were randomly divided into experimental and control groups. The first group performed Pilates exercises for 12 weeks incrementally, 3 sessions a week and each session lasted 50 minutes, and for the control group who continued the routine life program, before and after the implementation of the exercise protocol, blood was taken and ghrelin was measured by Eliza method. Data was analyzed by SPSS software (version 22) and Mann-Whitney test. P