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With the ripening of 3D printing technology and the discovery of a variety of printable materials, 3D-printed vascular stents provide new treatment options for patients with angiocardiopathy. Bioresorbable stent not only combines the advantages of metallic stent and drug-coated balloon, but also avoids the disadvantages of them. 3D printing is also an economical and efficient way to produce stents and makes it possible to construct complex structures. In this study, stents made from poly(l-lactic acid) (PLLA), poly(ε-caprolactone) (PCL) and poly(l-lactide-co-caprolactone) (PLCL) were manufactured by 3D printing and evaluated for radial strength, crystallinity and molecular weight. PLCL copolymerized by different proportions of lactic acid and caprolactone showed different mechanical and degradation properties. This demonstrated the potential of 3D printing as a low-cost and high throughput method for stent manufacturing. The PLLA and PLCL 95/5 stents had similar mechanical properties, whereas PLCL 85/15 and PCL stents both had relatively low radial strength. In general, PLCL 95/5 had a faster degradation rate than PLLA. These two materials were made into peripheral vascular bioresorbable scaffolds (BRS) and further studied by additional bench testing. PLCL 95/5 peripheral BRS had superior mechanical properties in terms of flexural/bending fatigue and compression resistance.

Stress urinary incontinence (SUI) impacts ~1/3 of women over age 50. Negative publicity around PP meshes used in pelvic prolapse repair drives the need for identifying alternative biomaterials for SUI repair. Our study evaluated in vivo response to collagen sling implanted in an ovine model. Electrocompacted collagen threads were filament wound as slings and crosslinked in genipin. Collagen slings were implanted suburethrally mimicking the transvaginal tape technique. Main study groups were: Collagen sling (n = 3, 6 months) and PP sling (n = 3, 6 months). Collagen sling was also tested at 3-weeks (n = 1) to observe early-stage tissue response and 1-year (n = 2) to assess biomaterial longevity in a preliminary capacity. Collagen slings healed to a fibrous ligament texture at 6 months and maintained such texture to 1 year. Histological scoring indicated biocompatible responses to collagen slings with no adverse events. All study groups exhibited complete tissue ingrowth and interstitial de novo collagen deposition at all time points. Collagen threads induced orderly de novo collagen deposition that was aligned along long axes of threads. Tissue infiltrated collagen slings that were explanted at 6 and 12 months presented similar structural strength with native tissues such as vagina and fascia, and PP (Lynx) slings (p .05). With the limitation of low number of animals per time point in hindsight, this preliminary study justifies evaluation of collagen slings in a larger sample size of animals, particularly to assess persistence of ligamentous tissue response over longer durations than 1-year.

A female scalloped hammerhead shark (Sphyrna lewini) conducted a species record deep dive to 1240 m in coastal-pelagic waters off Hawaii Island. This extends the deepest known depth range of the species by over 200 m (650 ft) and highlights the question of the extent to which deep-diving activity is mediated by physiological constraints, such as temperature and oxygen availability.

Anti–SARS-CoV-2 antibodies have been used in health care and clinical settings to prevent and treat COVID-19. The National Institutes of Health convened a virtual summit on 15 June 2021 to summarize existing knowledge and to identify key unanswered scientific questions to catalyze future development of these antibodies., As the fourth wave of the SARS-CoV-2 pandemic encircles the globe, there remains an urgent challenge to identify safe and effective treatment and prevention strategies that can be implemented in a range of health care and clinical settings. Substantial advances have been made in the use of anti–SARS-CoV-2 antibodies to mitigate the morbidity and mortality associated with COVID-19. On 15 June 2021, the National Institutes of Health, in collaboration with the U.S. Food and Drug Administration, convened a virtual summit to summarize existing knowledge on anti–SARS-CoV-2 antibodies and to identify key unanswered scientific questions to further catalyze the clinical development and implementation of antibodies.

Previous investigations have demonstrated that up to 7% of the distal femoral physis can be violated using a rigid, retrograde nail without growth inhibition or arrest. The purpose of this investigation was to evaluate the behavior of the distal femoral physis after retrograde femoral nail removal in a sheep model, with and without placement of an interpositional fat graft.Retrograde femoral nails were placed in 8 skeletally immature sheep. Implants were removed at 8 weeks, with the residual defects left open (n=4) or filled with autologous fat graft (n=4). Differences in femoral length between surgical versus contralateral control femurs were measured after an additional 3 (n=4) or 5 months (n=4) before sacrifice, and the physis was evaluated histologically.When compared with control limbs, femoral length was significantly shorter in limbs sacrificed at 3 months (mean: 3.9±1.3 mm; range: 2.7 to 5.7 mm) compared with limbs at 5 months (mean: 1.0±0.4 mm; range: 0.4 to 1.2 mm) ( P =0.005). No significant difference in mean shortening was appreciated in limbs without (2.4±1.6 mm) versus with fat grafting (2.5±2.3 mm) ( P =0.94). Histologic analysis revealed no osteoid formation across the physis in sheep sacrificed at 3 months, whereas there was evidence of early osteoid formation across the physis in sheep at 5 months. All specimens demonstrated evidence of an active physes.Femurs undergoing retrograde implant placement were significantly shorter when compared with control limbs in sheep sacrificed at 3 months, whereas differences were nominal in sheep sacrificed at 5 months after retrograde implant removal, suggesting growth inhibition with nail removal improved with time. Fat grafting across the distal femoral physis did not result in a significant difference in femoral lengths. Histologic evidence at 5 months revealed early development of a bone bridge, emphasizing the importance of follow-up to skeletal maturity in patients treated with retrograde nailing across an open physis.Level IV.

The VLBI Global Observing System, which is the next generation of geodetic VLBI and is called VGOS, observes simultaneously at four frequency bands in the range 3.0--10.7 GHz (expected to be extended to 14 GHz). Because source structure changes with frequency, we aim to study the source position estimates from the observations of this new VLBI system. Based on an ideal point source model, simulations are made to determine the relation between the source positions as determined by VGOS observations and the locations of the radio emission at the four bands. We obtained the source positions as determined by VGOS observations as a function of the source positions at the four frequency bands for both group and phase delays. The results reveal that if the location of the radio emission at one band is offset with respect to that at the other bands, the position estimate can be shifted to the opposite direction and even by more than three times that offset. The VGOS source positions will be very variable with time and very imprecise in the sense of relating to the locations of the radio emission at the four bands, if the effects of source structure are not modeled. The image alignment over frequency is essential in order to model the effects of source structure in VGOS observations, which is the only way to mitigate these strong frequency-dependent impacts on VGOS source positions., Comment: 10 pages, 4 figures, submitted to A&A

Background: Successful management of massive rotator cuff (RC) tendon tears represents a treatment challenge because of the limited intrinsic healing capacity of native tendons and the risk of repair failure. Biologic augmentation of massive RC tears utilizing scaffolds—capable of regenerating bulk tendon tissue to achieve a mechanically functional repair—represents an area of increasing clinical interest. Purpose: To investigate the histological and biomechanical outcomes after the use of a novel biologic scaffold fabricated from woven electrochemically aligned collagen (ELAC) threads as a suture-holding, fully load-bearing, defect-bridging scaffold with or without mesenchymal stem cells (MSCs) compared with direct repair in the treatment of critically sized RC defects using a rabbit model. Study Design: Controlled laboratory study. Methods: A total of 34 New Zealand White rabbits underwent iatrogenic creation of a critically sized defect (6 mm) in the infraspinatus tendon of 1 shoulder, with the contralateral shoulder utilized as an intact control. Specimens were divided into 4 groups: (1) gap—negative control without repair; (2) direct repair of the infraspinatus tendon—operative control; (3) tendon repair using ELAC; and (4) tendon repair using ELAC + MSCs. Repair outcomes were assessed at 6 months using micro–computed tomography, biomechanical testing, histology, and immunohistochemistry. Results: Specimens treated with ELAC demonstrated significantly less tendon retraction when compared with the direct repair group specimens ( P = .014). ELAC + MSCs possessed comparable biomechanical strength (178 ± 50 N) to intact control shoulders (199 ± 35 N) ( P = .554). Histological analyses demonstrated abundant, well-aligned de novo collagen around ELAC threads in both the ELAC and the ELAC + MSC shoulders, with ELAC + MSC specimens demonstrating increased ELAC resorption (7% vs 37%, respectively; P = .002). The presence of extracellular matrix components, collagen type I, and tenomodulin, indicating tendon-like tissue formation, was appreciated in both the ELAC and the ELAC + MSC groups. Conclusion: The application of MSCs to ELAC scaffolds improved biomechanical and histological outcomes when compared with direct repair for the treatment of critically sized defects of the RC in a rabbit model. Clinical Relevance: This study demonstrates the feasibility of repairing segmental tendon defects with a load-bearing, collagen biotextile in an animal model, showing the potential applicability of RC repair supplementation using allogeneic stem cells.

Sung Wan Kim's initial efforts as an independent investigator were focused on improving the understanding of the early events in blood/material interactions with the goal to develop blood compatible materials for application in medical devices and prostheses. These initial efforts were centered around blood protein adsorption on biomaterials and related mechanisms of thrombus formation (thrombosis). Ultimately, Sung Wan's efforts were expanded to studies of the non-thrombogenic nature of heparinized biomaterials, prostaglandin biomaterials, and block copolymer systems. These studies were supported by two NIH grants for 22 and 19 years, respectively, and a NIH Career Development Award. Moreover, these studies resulted in over 140 peer-reviewed publications and training of many students and postdoctoral scientists. The intent of this paper is to identify key concepts, papers, and contributions by Sung Wan and his colleagues that fall within the four aforementioned research categories. In this context, many of Sung Wan's early efforts contributed directly to Utah's biomaterials efforts and the Total Artificial Heart program at the time, while providing the foundation for the productive international Triangle Collaboration as well as his following work in polymer-controlled drug releasing systems.

Photothermal therapy (PTT) is one of the most promising techniques for cancer tumor ablation. Nanoparticles are increasingly being investigated for use with PTT and can serve as theranostic agents. Based on the ability of near-infrared nano-photo-absorbers to generate heat under laser irradiation, PTT could prove advantageous in certain situations over more classical cancer therapies. To analyze the efficacy of nanoparticle-based PTT, preclinical in vitro studies typically use 2D cultures, but this method cannot completely mimic the complex tumor organization, bioactivity, and physiology that all control the complex penetration depth, biodistribution, and tissue diffusion parameters of nanomaterials in vivo. To fill this knowledge gap, 3D culture systems have been explored for PTT analysis. These models provide more realistic microenvironments that allow spatiotemporal oxygen gradients and cancer cell adaptations to be considered. This review highlights the work that has been done to advance 3D models for cancer microenvironment modeling, specifically in the context of advanced, functionalized nanoparticle-directed PTT.

White sharks (Carcharodon carcharias) are the largest shark species to display regional endothermy. This capability likely facilitates exploitation of resources beyond thermal tolerance thresholds of potential sympatric competitors as well as sustained elevated swim speeds, but results in increased metabolic costs of adults, which has been documented in different studies. Little, however, is known of the metabolic requirements in free-swimming juveniles of the species, due to their large size at birth and challenges in measuring their oxygen consumption rates in captivity. We used trilateration of positional data from high resolution acoustic-telemetry to derive swim speeds from speed-over-ground calculations for eighteen free-swimming individual juvenile white sharks, and subsequently estimate associated mass-specific oxygen consumption rates as a proxy for field routine metabolic rates. Resulting estimates of mass-specific field routine metabolic rates (368 mg O2 kg−1 h−1 ± 27 mg O2 kg−1 h−1 [mean ± S.D.]) are markedly lower than those reported in sub-adult and adult white sharks by previous studies. We argue that median cruising speeds while aggregating at nearshore nursery habitats (0.6 m s-1 [mean ± S.E = 0.59 ± 0.001], 0.3 TL s-1) are likely a feature of behavioral strategies designed to optimize bioenergetic efficiency, by modulating activity rates in response to environmental temperature profiles to buffer heat loss and maintain homeostasis. Such behavioral strategies more closely resemble those exhibited in ectotherm sharks, than mature conspecifics.

Description, Large-scale validation is extremely challenging as validation remains “in the eye of the beholder.”, Large-scale generation of protein capture reagents remains a technical challenge, but their generation is just the beginning. Validation is a critical, iterative process that yields different results for different uses. Independent, community-based validation offers the possibility of transparent data sharing, with use case–specific results made broadly available. This type of resource, which can grow as new validation data are obtained for an expanding group of reagents, provides a community resource that should accompany future reagent-generating efforts. To address a pressing need for antibodies or other reagents that recognize human proteins, the National Institutes of Health Common Fund launched the Protein Capture Reagents Program in 2010 as a pilot to target human transcription factors. Here, we describe lessons learned from this program concerning generation and validation of research reagents, which we believe are generally applicable for future research endeavors working in a similar space.

We report the results of position ties for short baselines at eight geodetic sites based on phase delays that are extracted from global geodetic very-long-baseline interferometry (VLBI) observation...

Very Long Baseline Interferometry (VLBI) serves as one of the common geodetic methods to define the global reference frames and monitor Earth's orientation variations. The technical upgrade of the VLBI method known as the VLBI Global Observing System (VGOS) includes a critical re-design of the observed frequencies from the dual band mode (S and X band, i.e. 2 GHz and 8 GHz) to observations in a broadband (2 – 14 GHz). Since 2019 the first VGOS experiments are available for the geodetic analysis in free access at the International VLBI service for Geodesy and Astrometry (IVS). Also regional-only subnetworks such as European VLBI stations have succeeded already in VGOS mode. Based on these brand-new observations we review the current geodetic data analysis workflow to build a bridge between geodetic observed delays derived from different bands.

M2 macrophages are associated with deposition of interstitial collagen and other extracellular matrix proteins during the course wound healing and also inflammatory response to biomaterials. Developing advanced biomaterials to promote the M2 subtype may be an effective way to improve tissue reinforcement surgery outcomes. In this study, the effect of genipin, a naturally derived crosslinking agent, on M0 → M2-polarization was investigated. Genipin was introduced either indirectly by seeding cells on aligned collagen biotextiles that are crosslinked by the agent or in soluble form by direct addition to the culture medium. Cellular elongation effects on macrophage polarization induced by the collagen biotextile were also investigated as a potential inducer of macrophage polarization. M0 and M2 macrophages demonstrated significant elongation on the surface of aligned collagen threads, while cells of the M1 subtype-maintained a round phenotype. M0 → M2 polarization, as reflected by arginase and Ym-1 production, was observed on collagen threads only when the threads were crosslinked by genipin, implicating genipin as a more potent inducer of the regenerative phenotype compared to cytoskeletal elongation. The addition of genipin to the culture medium directly also drove the emergence of pro-regenerative phenotype as measured by the markers (arginase and Ym-1) and through the activation of the pSTAT6-PPAR-gamma pathway. This study indicates that genipin-crosslinked collagen biotextiles can be used as a delivery platform to promote regenerative response after biomaterial implantation. Statement of significance The immune response is one of the key determinants of tissue repair and regeneration rate, and outcome. The M2 macrophage subtype is known to resolve the inflammatory response and support tissue repair by producing pro-regenerative factors. Therefore, a biomaterial that promotes M2 sub-type can be a viable strategy to enhance tissue regeneration. In this study, we investigated genipin-crosslinked electrochemically aligned collagen biotextiles for their capacity to induce pro-regenerative polarization of M0 macrophages. The results demonstrated that genipin, rather than matrix-induced cellular elongation, was responsible for M0 → M2 polarization in the absence of other bioinductive factors and maintaining the M2 polarized status of macrophages. Furthermore, we identified that genipin polarizes the M2 macrophage phenotype via activation of the pSTAT6-PPAR-gamma pathway.

Faraday rotation of polarized emission from pulsars measured at radio frequencies provides a powerful tool to investigate the interstellar and interplanetary magnetic fields. However, besides being sensitive to the astrophysical media, pulsar observations in radio are affected by the highly time-variable ionosphere. In this article, the amount of ionospheric Faraday rotation has been computed by assuming a thin layer model. For this aim, ionospheric maps of the free electron density (based on Global Positioning System data) and semi-empirical geomagnetic models are needed. Through the data of five highly polarized pulsars observed with the individual German LOw-Frequency ARray stations, we investigate the performances of the ionospheric modelling. In addition, we estimate the parameters of the systematics and the correlated noise generated by the residual unmodelled ionospheric effects, and show the comparison of the different free-electron density maps. For the best ionospheric maps, we have found that the rotation measure corrections on one-year timescales after subtraction of diurnal periodicity are accurate to $\sim$ 0.06--0.07 rad m$^{-2}$., 18 pages, 13 figures, 4 tables

Despite advancements in surgical techniques and materials for rotator cuff repair procedures, primary repair failures remain common. This study examines the use of electrochemically aligned collagen (ELAC) threads woven into biotextile scaffolds as grafts to repair critical infraspinatus tendon defects in New Zealand White rabbits. Three surgical treatment groups were evaluated: rabbits undergoing direct repair as operative controls, rabbits receiving ELAC scaffolds alone, and rabbits treated with mesenchymal stem cell (MSC)-seeded ELAC scaffolds. In each animal, the intact, contralateral infraspinatus served as an internal positive control. Tendon-bone constructs were harvested after 3 months in vivo and outcome measures included biomechanical testing, histological staining, and immunohistochemical staining. Biomechanical testing revealed that maximum load-bearing capacity was comparable between all groups, while MSC-seeded scaffold repairs exhibited increased stiffness relative to non-seeded scaffold repairs. Histological staining revealed robust collagen deposition around ELAC fibers and increased cellularity within the continuum of woven scaffolds as compared to native tendon. Immunohistochemical staining revealed presence of collagens I and III in all groups, but procollagen I and the tendon-specific marker tenomodulin were only observed in seeded and non-seeded ELAC scaffold repairs. Findings of this pilot study warrant continued investigation of ELAC biotextile scaffolds for repair of critically-sized rotator cuff tendon defects. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1864-1876, 2019.

Several studies have suggested that women in science are less productive than men, and that this gap contributes to their under-representation in the ranks of senior researchers. However, few studies have examined the role of mentoring, and in particular mentor gender, on the productivity of female scientists early in their careers. Such efforts are limited by the difficulties of unambiguously linking mentees to their mentors and measuring the research productivity resulting from those relationships. Here we use our novel author disambiguation solution to investigate the role of self-identified gender in mentorship of 12,932 trainees who either successfully or unsuccessfully applied to the National Institutes of Health for research fellowships between fiscal years 2011 and 2017, applying a multi-dimensional framework to assess productivity. We found that, after normalizing for the funding level of mentors, the productivity of female and male mentees is indistinguishable; it is also independent of the gender of the mentor, other than in measures of clinical impact, where women mentored by women outperform other mentee-mentor dyads.

We report the relationship between the $Gaia$--VLBI position differences and the magnitudes of source structure effects in VLBI observations. Because the $Gaia$--VLBI position differences are statistically significant for a considerable number of common sources, we attempt to discuss and explain these position differences based on VLBI observations and available source images at cm-wavelengths. Based on the derived closure amplitude root-mean-square (CARMS), which quantifies the magnitudes of source structure effects in the VLBI observations used for building the third realization of the International Celestial Reference Frame, the arc lengths and normalized arc lengths of the position differences are examined in detail. The radio jet directions and the directions of the $Gaia$--VLBI position differences are investigated for a small sample of sources. Both the arc lengths and normalized arc lengths of the $Gaia$ and VLBI positions are found to increase with the CARMS values. The majority of the sources with statistically significant position differences are associated with the sources having extended structure. Radio source structure is the one of the major factors of these position differences, and it can be the dominate factor for a number of sources. The vectors of the $Gaia$ and VLBI position differences are parallel to the radio-jet directions, which is confirmed with stronger evidence., Comment: 13 pages, 7 figures, and 5 tables. Accepted to be published in Astronomy & Astrophysics

The new data release of the Gaia satellite operated by the European Space Agency recently published its 3rd data release (Early Data Release 3, EDR3). The dataset contains astrometric data of about 1.8 billion objects detected at optical frequencies and therefore it outperforms any catalog of astrometric information up to date. The reference frame defined by Gaia EDR3 is aligned to the International Celestial Reference System by referring to counterparts in its realization, the third International Celestial Reference Frame (ICRF3), which is calculated from very long baseline interferometry (VLBI) observations of extragalactic objects at radio frequencies. The Gaia dataset is known to be magnitude-dependent in terms of astrometric calibration. As the objects in ICRF3, although bright at radio frequencies, are mostly faint at optical frequencies, the optically bright Gaia frame has to be linked to ICRF3 by additional counterparts besides objects in ICRF3. The non-rotation of the optically bright Gaia frame is especially important as optically bright objects can, besides astrophysical studies, be used for navigation in space, where other geodetic systems like global navigation satellite systems are out of reach. Suitable additional counterparts are radio stars which are observed by VLBI relative to extragalactic objects in ICRF3. We discuss the orientation and spin differences between the optically bright Gaia EDR3 and VLBI data of radio stars and their impact on the Gaia data usage.

The Potsdam Open Source Radio Interferometry Tool (PORT) is the very long baseline interferometry (VLBI) analysis software developed and maintained at the GFZ German Research Centre for Geosciences. Chiefly, PORT is tasked with the timely processing of VLBI sessions and post-processing activities supporting the generation of celestial and terrestrial reference frames. In addition, it serves as a framework for research and development within the GFZ's VLBI working group and is part of the tool set employed in educating young researchers. Starting out from VLBI group delays, PORT estimates station and radio sources positions, as well as Earth orientation parameters, tropospheric parameters, and station clock offsets and drifts. The estimation procedures take into account all the necessary data analysis models that were agreed on for contributing to the ITRF2020 processing activities. The PORT code base is implemented in the MATLAB (R) and Python programming languages. It is licensed under the terms of the GNU General Public License and available for download at GFZ's Git server ., Publications of the Astronomical Society of the Pacific, 133 (1028)

The next-generation, broadband geodetic very long baseline interferometry system, named VGOS, is developing its global network, and VGOS networks with a small size of 3--7 stations have already made broadband observations from 2017 to 2019. We made quality assessments for two kinds of observables in the 21 VGOS sessions currently available: group delay and differential total electron content ($\delta$TEC). Our study reveals that the random measurement noise of VGOS group delays is at the level of less than 2 ps (1 ps = 10$^{-12}$ s), while the contributions from systematic error sources, mainly source structure related, are at the level of 20 ps. Due to the significant improvement in measurement noise, source structure effects with relatively small magnitudes that are not overwhelming in the S/X VLBI system, for instance 10 ps, are clearly visible in VGOS observations. Another critical error source in VGOS observations is discrete delay jumps, for instance, a systematic offset of about 310 ps or integer multiples of that. The predominant causative factor is found to be related to source structure. The measurement noise level of $\delta$TEC observables is about 0.07 TECU, but the systematic effects are five times larger than that. A strong correlation between group delay and $\delta$TEC observables is discovered with a trend of 40 ps/TECU for observations with large structure effects; there is a second trend in the range 60 ps/TECU to 70 ps/TECU when the measurement noise is dominant., Comment: 25 pages, 11 figures, and accepted for publication in Journal of Geodesy

The NIH Virtual SARS-CoV-2 Antiviral Summit, held on 6 November 2020, was organized to provide an overview on the status and challenges in developing antiviral therapeutics for coronavirus disease 2019 (COVID-19), including combinations of antivirals. Scientific experts from the public and private sectors convened virtually during a live videocast to discuss severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets for drug discovery as well as the preclinical tools needed to develop and evaluate effective small-molecule antivirals. The goals of the Summit were to review the current state of the science, identify unmet research needs, share insights and lessons learned from treating other infectious diseases, identify opportunities for public-private partnerships, and assist the research community in designing and developing antiviral therapeutics. This report includes an overview of therapeutic approaches, individual panel summaries, and a summary of the discussions and perspectives on the challenges ahead for antiviral development.

High-precision pulsar timing requires accurate corrections for dispersive delays of radio waves, parametrized by the dispersion measure (DM), particularly if these delays are variable in time. In a previous paper we studied the Solar-wind (SW) models used in pulsar timing to mitigate the excess of DM annually induced by the SW, and found these to be insufficient for high-precision pulsar timing. Here we analyze additional pulsar datasets to further investigate which aspects of the SW models currently used in pulsar timing can be readily improved, and at what levels of timing precision SW mitigation is possible. Our goals are to verify: a) whether the data are better described by a spherical model of the SW with a time-variable amplitude rather than a time-invariant one as suggested in literature, b) whether a temporal trend of such a model's amplitudes can be detected. We use the pulsar-timing technique on low-frequency pulsar observations to estimate the DM and quantify how this value changes as the Earth moves around the Sun. Specifically, we monitor the DM in weekly to monthly observations of 14 pulsars taken with LOFAR across time spans of up to 6 years. We develop an informed algorithm to separate the interstellar variations in DM from those caused by the SW and demonstrate the functionality of this algorithm with extensive simulations. Assuming a spherically symmetric model for the SW density, we derive the amplitude of this model for each year of observations. We show that a spherical model with time-variable amplitude models the observations better than a spherical model with constant amplitude, but that both approaches leave significant SW induced delays uncorrected in a number of pulsars in the sample. The amplitude of the spherical model is found to be variable in time, as opposed to what has been previously suggested., 14 pages, 9 figures. Accepted for publication in Astronomy and Astrophysics

We present Space-VLBI RadioAstron observations at 1.6 GHz and 4.8 GHz of the flat spectrum radio quasar 3C 273, with detections on baselines up to 4.5 and 3.3 Earth Diameters, respectively. Achieving the best angular resolution at 1.6 GHz to date, we have imaged limb-brightening in the jet, not previously detected in this source. In contrast, at 4.8 GHz, we detected emission from a central stream of plasma, with a spatial distribution complementary to the limb-brightened emission, indicating an origin in the spine of the jet. While a stratification across the jet width in the flow density, internal energy, magnetic field, or bulk flow velocity are usually invoked to explain the limb-brightening, the different jet structure detected at the two frequencies probably requires a stratification in the emitting electron energy distribution. Future dedicated numerical simulations will allow the determination of which combination of physical parameters are needed to reproduce the spine-sheath structure observed by Space-VLBI with RadioAstron in 3C 273. © ESO 2021., JLG and AF acknowledge financial support from the Spanish Ministerio de Economia y Competitividad (grants AYA2016-80889-P, PID2019-108995GB-C21), the Consejeria de Economia, Conocimiento, Empresas y Universidad of the Junta de Andalucia (grant P18-FR-1769), the Consejo Superior de Investigaciones Cientificas (grant 2019AEP112), and the State Agency for Research of the Spanish MCIU through the Center of Excellence Severo Ochoa award for the Instituto de Astrofisica de Andalucia (SEV-2017-0709). APL, YYK, and ABP were supported by the Russian Science Foundation (project 20-62-46021). TS was partly supported by the Academy of Finland projects 274477 and 315721. MP acknowledges the support by the Spanish Ministerio de Ciencia e Innovacion (MICINN) under grant PID2019-105510GB-C31. MP and JMM acknowledge financial support from the Spanish Ministry of Science through Grants PID2019-107427GB-C33 and AYA2016-77237-C3-3-P, and from the Generalitat Valenciana through grant PROMETEU/2019/071. JMA was supported by the German Research Foundation grant HE5937/2-2. LIG acknowledges support by the CSIRO Distinguished Visitor Programme. The RadioAstron project is led by the Astro Space Center of the Lebedev Physical Institute of the Russian Academy of Sciences and the Lavochkin Scientific and Production Association under a contract with the Roscosmos State Corporation, in collaboration with partner organizations in Russia and other countries. This publication has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 730562 [RadioNet].

This report describes a study of pardon petition evaluations that were performed by the Office of the Pardon Attorney (OPA), a unit in the U.S. Department of Justice that processes thousands of requests for executive clemency each year. A statistical examination was conducted on how OPA screens incoming petitions for technical compliance, investigates the facts underlying each petitioner’s request for clemency, and applies substantive standards for evaluating the merits of such petitions when crafting recommendations to the U.S. President to grant or deny relief. Data were analyzed for any patterns in OPA decisions that indicated statistically significant evidence of racial or ethnic bias.