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2. Orbital Decompression for Graves' Disease: Exposure Through a Modified Blepharoplasty Incision

Author

Nancy A. Tucker, François Codère, and James H. Antoszyk

Subjects
medicine.medical_specialty, Blepharoplasty, genetic structures, business.operation, Hypesthesia, business.industry, Decompression, medicine.medical_treatment, medicine.disease, eye diseases, Surgery, Optic neuropathy, medicine.anatomical_structure, medicine, sense organs, Eyelid, business, Strabismus, Transorbital, Surgical incision
Abstract

A "transorbital" three-wall decompression through a modified blepharoplasty incision was used to treat 19 orbits for either cosmetic disfigurement or optic neuropathy. In the 14 orbits with disfigurement, surgical retroplacement averaged 5.2 mm; vision improved to 20/40 or better in four of five eyes with optic neuropathy. Complications attributed to the surgery included: acquired strabismus (two transient, one permanent) and infraorbital hypesthesia (one transient, one permanent). This technique's advantages are: 1) a single incision with wide exposure, 2) a low incidence of permanent strabismus, 3} a lateral orbital rim and canthal tendon preservation, and 4) a large reduction in proptosis.

Published
1992
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3. CONTRIBUTORS

Author

Richard L. Abbott, Natalie A. Afshari, Jaya Agrawal, Shishir Agrawal, Trilok P. Agrawal, Levent Akduman, Esen K. Akpek, Amal Al-Sayyed, Thomas A. Albini, Deborah M. Alcorn, Amar Alwitry, Anouk Amzel, Nicole J. Anderson, Ejaz A. Ansari, Andrew Antoszyk, James H. Antoszyk, James V. Aquavella, Sumaira A. Arain, J. Fernando Arévalo, Guruswami Arunagiri, Carlos W. Arzabe, La-ongsri Atchaneeyasakul, Huban Atilla, Ümit Aykan, Brandon D. Ayres, Juan J. Barbón, Kristi Bailey, Frank G. Baloh, Irina S. Barequet, André Barkhuizen, Michael A. Bearn, Rubens Belfort, A. Robert Bellows, Audina M. Berrocal, Marijke Wefers Bettink-Remeijer, Anuja Bhandari, M. Tariq Bhatti, Mark S. Blumenkranz, Kostas G. Boboridis, James P. Bolling, Vivien Boniuk, Paul Jorge Botelho, Paul W. Brazis, Fion D. Bremner, Edward G. Buckley, John D. Bullock, David Matthew Bushley, Jorge Alberto F. Caldeira, Anne Carricajo, Gian Maria Cavallini, Matilda Frances Chan, Damon B. Chandler, H. Channa, Devron H. Char, Steve Charles, Teresa C. Chen, Steven S.T. Ching, Christophe Chiquet, Phillip Hyunchul, Timothy Y. Chou, Stephen P. Christiansen, Kelly D. Chung, George A. Cioffi, Michael P. Clarke, David K. Coats, Elisabeth J. Cohen, R. Max Conway, Catherine Creuzot-Garcher, Emmett T. Cunningham, Theodore H. Curtis, Roger A. Dailey, Richard M. Davis, Romain De Cock, Jan-Tjeerd H.N. de Faber, Daniel de la Mano, Nick W.H.M. Dekkers, Monte Anthony Del Monte, David A. Della Rocca, Robert C. Della Rocca, Deepinder K. Dhaliwal, Diana V. Do, Peter J. Dolman, Sean P. Donahue, Eric D. Donnenfeld, Graham Duguid, Jay S. Duker, James P. Dunn, Steven P. Dunn, Hon-Vu Q. Duong, Robert A. Egan, Michael D. Eichler, Mays El-Dairi, Forrest J. Ellis, Geoffrey Emerson, M. Vaughn Emerson, Laura B. Enyedi, Teodoro Evans, Julie Falardeau, Bishara M. Faris, Marianne E. Feitl, Warren L. Felton, Stephen S. Feman, Timothy J ffytche, Christina J. Flaxel, Rod Foroozan, Allen Foster, Frederick T. Fraunfelder, Frederick W. Fraunfelder, H. Mackenzie Freeman, Mitchell H. Friedlaender, Larry P. Frohman, Wayne E. Fung, Philippe Gain, Jaime R. Gaitan, Stephen Gancher, Tim Gard, Devin M. Gattey, Peter L. Gehlbach, Mehdi Ghajarnia, Vinícius Coral Ghanem, Amit Kumar Ghosh, Chandak Ghosh, Matthew Giegengack, Geoffrey Gladstone, Daniel H. Gold, Richard L. Golub, Dan S. Gombos, George M. Gombos, William V. Good, Shawn Goodman, John D. Gottsch, Srinivas Goverdhan, Baird S. Grimson, Adolfo Güemes, Roberto Guerra, Julia A. Haller, Kristin M. Hammersmith, Irvin L. Handelman, Roderick N. Hargrove, Michael S. Harney, Richard A. Harper, Sarah R. Hatt, Barbara S. Hawkins, Sohan S. Hayreh, Arnd Heiligenhaus, Carsten Heinz, Leon W. Herndon, Simon J. Hickman, Koji Hirano, Edward J. Holland, Gary N. Holland, Eric R. Holz, Sachiko Hommura, Jeffrey D. Horn, Richard B. Hornick, H. Dunbar Hoskins, James W. Hung, Brian A. Hunter, Krista A. Hunter, Alex P. Hunyor, Brian Hurwitz, Thomas S. Hwang, Robert A. Hyndiuk, Ozge Ilhan-Sarac, Edsel Ing, Masanori Ino-ue, Carlos M. Isada, Saylin Iturriaga, Joseph D. Iuorno, Andrew G. Iwach, Mohan N. Iyer, Natalio J. Izquierdo, Lee M. Jampol, Suzanne Johnston, Sibel Kadayifçilar, Ian H. Kaden, Dieudonne Kaimbo Wa Kaimbo, Rashmis Kapur, Peter R. Kastl, Garyfallia Katsavounidou, Ayat Kazerouni, Michael Kazim, Sanjay R. Kedhar, Ronald V. Keech, Robert C. Kersten, Marshall P. Keys, Sangeeta Khanna, Peng Tee Khaw, James L. Kinyoun, Caitriona Kirwan, Tero Kivelä, Michael L. Klein, Stephen A. Klotz, John Ko, Regis P. Kowalski, Jay H. Krachmer, Theodore Krupin, Ferenc Kuhn, Abhaya Vivek Kulkarni, Robert C. Kwun, Peter R. Laibson, Rohit R. Lakhanpal, Byron L. Lam, Laurent Lamer, David P. Lawlor, Andrew W. Lawton, Alan B. Leahey, Russell LeBoyer, Andrew G. Lee, Wen-Hsiang Lee, William Barry Lee, Sharon S. Lehman, Howard M. Leibowitz, James Leong, Alex V. Levin, Leonard A. Levin, Mark R. Levine, Norman S. Levy, Thomas J. Liesegang, Lyndell L. Lim, Linda H. Lin, Richard D. Lisman, David Litoff, James C. Liu, Evan Loft, Ronald R. Lubritz, David C.W. Mabey, Ian A. Mackie, Srilakshmi Maguluri, M. Maliki, Nick Mamalis, Mark J. Mannis, Steven L. Mansberger, Ahmad M. Mansour, Alexandre S. Marcon, Italo M. Marcon, Peter B. Marsh, Rookaya Mather, William D. Mathers, K. Matti Saari, Louise A. Mawn, Penny J. McAllum, Rex M. McCallum, Peter McCluskey, Gregory J. McCormick, Steven A. McCormick, James P. McCulley, John G. McHenry, Alan A. McNab, Jared J. Mee, Douglas L. Meier, David M. Meisler, Saul C. Merin, Dale R. Meyer, Roger F. Meyer, Kevin S. Michels, Tatyana Milman, Roni Mintz, Chantal F Morel, William R. Morris, Mark L. Moster, John Mourani, Cristina Muccioli, Raghu C. Mudumbai, Fernando H. Murillo-Lopez, Shoib Myint, Parveen K Nagra, A Naoumi, John Nassif, Michelle T. Nee, Marcelo V. Netto, John D. Ng, Hau T. Nguyen, Quan Dong Nguyen, Denis M. O'Day, A. Justin O'Day, Henry S. O'Halloran, Michael O'Keefe, Fumiki Okamoto, Richard J. Olson, James C. Orcutt, Sema Oruc Dundar, Aaron Osbourne, Maristela Amaral Palazzi, Earl A. Palmer, Maria Papadopoulos, Jeffrey R. Parnell, Cameron F. Parsa, Sanjay V. Patel, Emily Patterson, Scott D. Pendergast, Henry D. Perry, Keith Roberson Peters, Stephanie M. Po, Russell Pokroy, Allen Michael Putterman, Rubén Queiro, Nastaran Rafiei, Bahram Rahmani, Christopher J Rapuano, Karim Rasheed, S.R. Rathinam, Lawrence A. Raymond, Russell W. Read, August Lafayette, Franco M. Recchia, James J. Reidy, Adam C. Reynolds, Larry F. Rich, Robert Ritch, Richard M. Robb, Pierre-Yves Robert, Joseph E. Robertson, Shiyoung Roh, Jean-Paul Romanet, Jack Rootman, Barbara L. Roque, Manolette R. Roque, Arthur L. Rosenbaum, James Todd Rosenbaum, F. Hampton Roy, Paul A. Rundle, Alfredo A. Sadun, Norman A. Saffra, Sarwat Salim, John R. Samples, Alvina Pauline D Santiago, David A. Saperstein, Richard A. Saunders, James A. Savage, Tina A. Scheufele, Vivian Schiedler, Thomas K. Schlesinger, Abraham Schlossman, Lee K. Schwartz, Ingrid U. Scott, Jennifer Scruggs, Ernesto I. Segal, Ismail A. Shalaby, Aziz Sheikh, John D. Sheppard, Mark D. Sherman, Carol L. Shields, Jerry A. Shields, Amarpreet Singh, Christopher N. Singh, Eric L. Singman, Donna Siracuse-Lee, Aaron D. Smalley, Patricia W. Smith, Anthony W. Solomon, Hassane Souhail, Daniel H. Spitzberg, Thomas C. Spoor, Robert L. Stamper, Walter J. Stark, Eric A. Steele, Thomas L. Steinemann, Ann U. Stout, J. Timothy Stout, R. Doyle Stulting, Alan Sugar, Joel Sugar, Donny W. Suh, Eric B. Suhler, John H. Sullivan, John Everett Sutphin, Kenneth C. Swan, Khalid F. Tabbara, Mandeep S. Tamber, Angelo P. Tanna, Sinan Tatlipinar, Ramin Tayani, Klaus D. Teichmann, Mark A. Terry, Clement Chee Yung Tham, A. Therzaz, Gilles Thuret, Christopher Graham Tinley, Andrea C. Tongue, Rodrigo J. Torres, Robert N. Tower, Elias I Traboulsi, Rupan Trikha, Brenda J. Tripathi, Ramesh C. Tripathi, Ilknur Tugal-Tutkun, Irene Tung, Judith A. M. Van Evendingen, Jean D. Vaudaux, Niteen S Wairagkar, Joseph D. Walrath, Rory McConn Walsh, David S. Walton, Ronald E. Warwar, Peter G. Watson, John J. Weiter, Richard G. Weleber, Fleming D. Wertz, Igor Westra, David T. Wheeler, Charles P. Wilkinson, David J. Wilson, M. Edward Wilson, Matthew W. Wilson, Steven E Wilson, John L. Wobig, Terry D. Wood, Lihteh Wu, Ozgur Yalcinbayir, Howard Shann-Cherng Ying, Peter N. Youssef, and Gerald W. Zaidman

Published
2008
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5. Interlocking Crawford Triangles in Frontalis Suspension

Author

Nancy A. Tucker, François Codère, Carl Ling, and James H. Antoszyk

Subjects
Adult, Male, Adolescent, Muscles, Eyelids, Frontalis suspension, Geometry, Anatomy, Middle Aged, Models, Biological, body regions, Ophthalmology, Child, Preschool, Retrospective analysis, Blepharoptosis, Humans, Female, Surgery, Plastic, Child, Interlocking, Aged, Mathematics
Abstract

• In Crawford's pattern of frontalis suspension, two bands are passed, one nasally and the other temporally, forming two base-down triangles with their apexes attached at the brow incisions. Over time, opposing vector forces in the center of the eyelid can cause "cheese-wiring" of the bands with resultant shortening of the inferior bases of both triangles and loosening of the suspensory loops. We modified the standard pattern by interlocking the bands centrally in the lid. A mathematical model was developed that demonstrates neutralization of these opposing forces, resulting in a symmetrical and flexible redistribution of the lifting forces. In support of this mathematical model, a retrospective analysis of 42 consecutive cases using this technique revealed good aesthetic results in terms of lid height, contour, and symmetry, with no important complications from this modification.

Published
1993
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6. Traumatic Hyphema in Children

Author

James H. Antoszyk, Robert D. Wagman, Stephen P. Kraft, John S. Crawford, and Murray D. Christianson

Subjects
Chemotherapy, medicine.medical_specialty, business.industry, medicine.medical_treatment, medicine.disease, Placebo, Traumatic hyphema, Surgery, Ophthalmology, Epsilon-Aminocaproic Acid, Oral administration, Anesthesia, Antifibrinolytic agent, medicine, business, Hyphema
Abstract

Forty-nine patients, ages 3 to 18 years, who sustained nonpenetrating unilateral trauma with hyphemas were assigned randomly to receive either 100 mg/kg of epsilon-aminocaproic acid (EACA), an antifibrinolytic agent, orally every 4 hours for 5 days (maximum 30 g/day) or a placebo. No patients ingested acetylsalicylic acid (ASA)-containing compounds before or during admission. Two patients of 24 treated with EACA and 1 of 25 given placebo had rebleeds. The hyphemas in the EACA-treated group took significantly longer to clear (mean, 5.3 versus 2.6 days; P

Published
1987
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7. Variable expressivity of autosomal dominant anterior segment mesenchymal dysgenesis in six generations

Author

James H. Antoszyk, Robert E. Ferrell, Frank L. Kretzer, Helen M. Hittner, and Robert E. Mehta

Subjects
Proband, Adult, Male, Visual acuity, genetic structures, Adolescent, Biology, Cataract, Congenital Abnormalities, Cornea, Corneal Transplantation, Cataracts, medicine, Humans, Anterior segment mesenchymal dysgenesis, Eye Abnormalities, Child, Descemet Membrane, Genes, Dominant, Infant, Optic Nerve, Anatomy, Middle Aged, medicine.disease, eye diseases, Pedigree, Ophthalmology, Microscopy, Electron, Child, Preschool, Optic cup (embryology), Optic nerve, Female, sense organs, medicine.symptom
Abstract

Of 58 members in a six-generation family with anterior segment mesenchymal dysgenesis with variable expressivity, 21 of 35 members (60%) at risk were affected. Of the 15 living affected family members, nine (60%) had visual acuities of 6/12 (20/40) or better in at least one eye, five (33%) had visual acuities between 6/15 and 6/60 (20/50 and 20/200) in at least one eye, and one (7%) had a visual acuity of less than counting fingers at one foot in both eyes. All nine affected patients who underwent slit-lamp examinations had corneal abnormalities with and without synechiae. All 15 affected patients also had cataracts, and three of the 15 (20%) had optic nerve abnormalities. In a corneal button from the severely affected proband, Descemet's layer and endothelial cells were absent even in the periphery. Other corneal and lenticular changes were secondary to the primary endothelial defect. Anterior segment mesenchymal dysgenesis in this family appeared to be caused by an aberration of the first wave of mesenchyme from the rim of the optic cup.

Published
1982

8. 726 AUTOSOMAL DOMINANT ANTERIOR SEGMENT DYSGENESIS WITH VARIABLE EXPRESSIVITY: PROBABLE LINKAGE TO MNS BLOOD GROUP ON CHROMOSOME 4

Author

Frank L Kretzer, James H Antoszyk, Arnold J Rudolph, Helen M. Hittner, and Robert E. Ferrell

Subjects
Genetics, medicine.medical_specialty, Visual acuity, genetic structures, Corneal Transplant, Biology, eye diseases, Epithelium, Basal (phylogenetics), Dysgenesis, Chromosome 4, medicine.anatomical_structure, Cornea, Lens (anatomy), Ophthalmology, Pediatrics, Perinatology and Child Health, medicine, sense organs, medicine.symptom
Abstract

An autosomal dominant anterior segment dysgenesis (ADASD) with variable expressivity affecting members of at least eight generations was identified. One branch of the family involving five generations with 21 of 35 (60%) members affected was studied. This included sixteen affected (9 males and 7 females) who were still living. Clinical findings ranged from anterior Schwalbe's line with mild cataract to severe corneal opacification with moderate cataract while visual acuity varied from 20/20 to hand motion only. The propositus had a corneal transplant and cataract extraction on one eye at age 6 weeks. Light and electron microscopic analyses demonstrated that the cornea had the following abnormalities: basal epithelial cell protrusions into a thickened Bowman's layer (22-60μ), activated keratocytes throughout the entire stroma, no Descemet's layer or endothelial cells, an aggregation of keratocytes posteriorly. The lens showed focal aggregations of vesicles in cortical fibers with extensive epithelial atrophy. Maximum likelihood analysis between ADASD and 14 biochemical and serological markers showed probable linkage between ADASD and the MNS blood group on the long arm of chromosome 4 (Z = 3.48).

Published
1981
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