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Advances in space weather science and small satellite (SmallSat) technology have proceeded in parallel over the past two decades, but better communication and coordination is needed among the respective worldwide communities contributing to this rapid progress. We identify six areas where improved international coordination is especially desirable, including: (1) orbital debris mitigation; (2) spectrum management; (3) export control regulations; (4) access to timely and low-cost launch opportunities; (5) inclusive data policies; and (6) education. We argue the need for internationally coordinated policies and programs to promote the use of SmallSats for space weather research and forecasting while realizing maximum scientific and technical advances through the integration of these two increasingly important endeavors., Comment: Commentary submitted to Space Weather; accepted and in press

The 2017 Space Weather Enterprise Forum, held June 27, focused on the vital role of partnerships in order to establish an effective and successful national space weather program. Experts and users from the many government agencies, industry, academia, and policy makers gathered to discuss space weather impacts and mitigation strategies, the relevant services and supporting infrastructure, and the vital role cross-cutting partnerships must play for successful implementation of the National Space Weather Action Plan.

Dust grains in various astrophysical environments are generally charged electrostatically by photoelectric emissions with radiation from nearby sources, or by electron/ion collisions by sticking or secondary electron emissions (SEES). The high vacuum environment on the lunar surface leads to some unusual physical and dynamical phenomena involving dust grains with high adhesive characteristics, and levitation and transportation over long distances. Knowledge of the dust grain charges and equilibrium potentials is important for understanding a variety of physical and dynamical processes in the interstellar medium, and heliospheric, interplanetary/ planetary, and lunar environments. It has been well recognized that the charging properties of individual micron-/submicron-size dust grains are expected to be substantially different from the corresponding values for bulk materials. In this paper, we present experimental results on the charging of individual 0.2-13 m size dust grains selected from Apollo 11 and 17 dust samples, and spherical silica particles by exposing them to mono-energetic electron beams in the 10-200 eV energy range. The dust charging process by electron impact involving the SEES discussed is found to be a complex charging phenomenon with strong particle size dependence. The measurements indicate substantial differences between the polarity and magnitude of the dust charging rates of individual small-size dust grains, and the measurements and model properties of corresponding bulk materials. A more comprehensive plan of measurements of the charging properties of individual dust grains for developing a database for realistic models of dust charging in astrophysical and lunar environments is in progress.

The lunar surface is covered with a thick layer of sub-micron/micron size dust grains formed by meteoritic impact over billions of years. The fine dust grains are levitated and transported on the lunar surface, as indicated by the transient dust clouds observed over the lunar horizon during the Apollo 17 mission. Theoretical models suggest that the dust grains on the lunar surface are charged by the solar ultraviolet (UV) radiation as well as the solar wind. Even without any physical activity, the dust grains are levitated by electrostatic fields and transported away from the surface in the near vacuum environment of the Moon. The current dust charging and levitation models, however, do not fully explain the observed phenomena. Since the abundance of dust on the Moon's surface with its observed adhesive characteristics has the potential of severe impact on human habitat and operations and lifetime of a variety of equipment, it is necessary to investigate the charging properties and the lunar dust phenomena in order to develop appropriate mitigating strategies. Photoelectric emission induced by the solar UV radiation with photon energies higher than the work function (WF) of the grain materials is recognized to be the dominant process for charging of the lunar dust, and requires measurements of the photoelectric yields to determine the charging and equilibrium potentials of individual dust grains. In this paper, we present the first laboratory measurements of the photoelectric efficiencies and yields of individual sub-micron/micron size dust grains selected from sample returns of Apollo 17 and Luna-24 missions as well as similar size dust grains from the JSC-1 simulants. The measurements were made on a laboratory facility based on an electrodynamic balance that permits a variety of experiments to be conducted on individual sub-micron/micron size dust grains in simulated space environments. The photoelectric emission measurements indicate grain size dependence with the yield increasing by an order of magnitude for grains of sub-micron to several micron size radii, at which it reaches asymptotic values. The yield for large size grains is found to be more than an order of magnitude higher than the bulk measurements on lunar fines reported in the literature.

The overarching objective of the ILWS Geospace program is to facilitate system level science. This demands synoptic observations such as global auroral imaging. At present, there is no funded mission during ILWS that incorporates a global auroral imager. The imaging community needs to move now to address this important gap. While doing so, it is interesting to take stock of global auroral observations that have not been achieved, or that have been achieved only to a limited extent. These include simultaneous imaging across all relevant scales, spectral resolution of sufficient quality to allow for global maps of characteristic energy and energy flux of precipitating electrons, continuous global auroral imaging for time periods spanning long-duration geomagnetic events, systematic interhemispheric conjugate observations, auroral observations magnetically conjugate to in situ measurements, and automatic classification of auroral images. These observations can be achieved within the next decade. If they are, then they will facilitate exciting new science.

The photoelectric emission process is considered to be the dominant mechanism for charging of cosmic dust grains in many astrophysical environments. The grain charge and equilibrium potentials play an important role in the dynamical and physical processes that include heating of the neutral gas in the interstellar medium, coagulation processes in the dust clouds, and levitation and dynamical processes in the interplanetary medium and planetary surfaces and rings. An accurate evaluation of photoelectric emission processes requires knowledge of the photoelectric yields of individual dust grains of astrophysical composition as opposed to the values obtained from measurements on flat surfaces of bulk materials, as it is generally assumed on theoretical considerations that the yields for the small grains are much different from the bulk values. We present laboratory measurements of the photoelectric yields of individual dust grains of silica, olivine, and graphite of approx. 0.09-5 micrometer radii levitated in an electrodynamic balance and illuminated with ultraviolet radiation at 120-160 nm wavelengths. The measured yields are found to be substantially higher than the bulk values given in the literature and indicate a size dependence with larger particles having order-of-magnitude higher values than for submicron-size grains.

A Conference on Measurement Techniques for Solar and Space Physics was held April 20-24, 2015, in Boulder Colorado at the NCAR Center Green Campus. The present volume collects together the papers from this conference in the categories of Particles and Fields. This also includes neutral gas techniques as well as low energy ionospheric plasmas and their interactions with spacecrafts.

A Conference on Measurement Techniques for Solar and Space Physics was held on 20-24 April 2015 in Boulder, Colorado, at the National Center for Atmospheric Research Center Green Campus. The present volume collects together the conference papers for photons and ground-based categories. This gathering of over 200 scientists and instrumentalists was born out of the desire to collect in one place the latest experiment and instrument technologies required for advancement of scientific knowledge in the disciplines of solar and space physics. The two goals for this conference and the subsequent publication of its content are (a) to describe measurement techniques and technology development needed to advance high priority science in the fields of solar and space physics; and (b) to provide a survey or reference of techniques for in situ measurement and remote sensing of space plasmas. Towards this end, our goal has always been inspired by the two 1998 Geophysical Monographs (Nos. 102 and 103) entitled, "Measurement Techniques in Space Plasmas" (particles and fields) [Pfaff et al., 1998a, 1998b], which have served as a reference and resource for advanced students, engineers, and scientists who wish to learn the fundamentals of measurement techniques and technology in this field. Those monographs were the product of an American Geophysical Union Chapman Conference that took place in Santa Fe, NM, in 1995: "Measurement Techniques in Space Plasmas-What Works, What Doesn't." Two decades later, we believe that it is appropriate to revisit this subject, in light of recent advances in technology, research platforms, and analysis techniques. Moreover, we now include direct measurements of neutral gases in the upper atmosphere, optical imaging techniques, and remote observations in space and on the ground. Accordingly, the workshop was organized among four areas of measurement techniques: particles, fields, photons, and ground-based. This two-set volume is largely composed of the content of that workshop. Special attention is given to those techniques and technologies that demonstrate promise of significant advancement in measurements that will enable the highest priority science as described in the 2012 National Research Council Decadal Survey [Baker and Zurbuchen et al., 2013]. Additionally, a broad tutorial survey of the current technologies is provided to serve as reference material and as a basis from which advanced and innovative ideas can be discussed and pursued. Included are instrumentation and techniques to observe the solar environment from its interior to its outer atmosphere, the heliosphere out to the interstellar regions, in geospace, and other planetary magnetospheres and atmospheres. To make significant progress in priority science as expressed in the National Research Council solar and space physics decadal survey and recent NASA Heliophysics roadmaps, identification of enabling new measurement techniques and technologies to be developed is required. Also, it is valuable to the community and future scientists and engineers to have a complete survey of the techniques and technologies used by the practitioners of solar and space physics. As with the 1995 conference and subsequent 1998 publication, it is incumbent on the community to identify those measurements that are particularly challenging and still require new techniques to be identified and tested to enable the necessary accuracy and resolution of certain parameters to be achieved. The following is a partial list of the measurement technique categories that are featured in these special publications: Particles; Thermal plasma to MeV energetic particles, neutral gas properties including winds, density, temperature, and composition, and enhanced neutral atom imaging; Fields; DC electric and magnetic fields, plasma waves, and electron drift instruments from which the plasma velocity information provides a measure of the DC electric field; Photons; Instruments sensitive from the near-infrared to X-rays; Contributions of techniques and technology for optical design, optical components, sensors, material selection for cameras, telescopes, and spectrographs; Ground based; Remote sensing methods for solar and geospace activity and space weather. The focus includes solar observatories, all-sky cameras, lidars, and ionosphere thermosphere mesosphere observatory systems such as radars, ionosondes, GPS receivers, magnetometers, conjugate observations, and airborne campaigns. The present volume collects together the papers for photons and ground-based categories. The companion volume collects together the papers for particles and fields categories. It is recognized that there are measurement techniques that overlap among the four categories. For example, use of microchannel plate detectors is used in photon and particle measurement techniques or the observation of visible photons and magnetic fields in space and on the ground share common technologies. Therefore, the reader should consider the entire collection of papers as they seek to understand particular applications. We hope that these volumes will be as valuable as a reference for our community as the earlier 1998 volumes have been.

Direct imaging of the magnetosphere by instruments on the IMAGE spacecraft is supplemented by simultaneous observations of the global aurora in three far ultraviolet (FUV) wavelength bands. The purpose of the multi-wavelength imaging is to study the global auroral particle and energy input from the magnetosphere into the atmosphere. This paper describes the method for quantitative interpretation of FUV measurements. The Wide-Band Imaging Camera (WIC) provides broad band ultraviolet images of the aurora with maximum spatial resolution by imaging the nitrogen lines and bands between 140 and 180 nm wavelength. The Spectrographic Imager (SI), a dual wavelength monochromatic instrument, images both Doppler-shifted Lyman-α emissions produced by precipitating protons, in the SI-12 channel and OI 135.6 nm emissions in the SI-13 channel. From the SI-12 Doppler shifted Lyman-α images it is possible to obtain the precipitating proton flux provided assumptions are made regarding the mean energy of the protons. Knowledge of the proton (flux and energy) component allows the calculation of the contribution produced by protons in the WIC and SI-13 instruments. Comparison of the corrected WIC and SI-13 signals provides a measure of the electron mean energy, which can then be used to determine the electron energy flux. To accomplish this, reliable emission modeling and instrument calibrations are required. In-flight calibration using early-type stars was used to validate the pre-flight laboratory calibrations and determine long-term trends in sensitivity. In general, very reasonable agreement is found between in-situ measurements and remote quantitative determinations.

This is the first report of a substorm observed by the IMAGE FUV instruments permitting global observations of electron and proton produced auroras. On the 28th of June 2000 at 1956 UT in the pre-substorm phase at early evening local time the proton aurora was equatorward of the electron precipitation and near midnight they were collocated. There was bright electron and proton aurora in the post midday afternoon side. The sudden brightening of the aurora at substorm onset near midnight is seen in the electrons only although there are protons present at this location. During the expansive phase both the electrons and protons expand poleward. The electron aurora forms a bright surge at the poleward boundary while the protons just show diffuse spreading. The peak intensity of the protons did not change substantially during the entire event. The proton aurora is brighter on the dusk while the electron aurora on the dawn side. As the electron surge expands poleward it leaves the protons behind. The electrons form a discrete auroral feature near the aurora-polar cap boundary, which is devoid of substantial energetic (>1 keV) proton precipitation. The presence of precipitating protons at the point where the initial brightening is seen shows that substorms are initiated on closed field lines.

We are Studying the magnetic cloud event of January 6 - 11, 1997. Specifically, we have investigated the response of the magnetosphere to the shock wave in front of the magnetic cloud on January 10, 1997 using data from WIND, GEOTAIL and POLAR spacecraft as well as ground magnetometer data. The WIND spacecraft, which was located as about 104 Re upstream from the Earth (85.1, -55.2, -22.1) Re(sub GSM), observed the arrival of the shock wave front at 0050 UT. Geotail was located at the equatorial magnetopause (approx. 8.7 Re, 10.7 MLT, -7.46 MLAT), while POLAR was located in the northern dawn sector above the auroral zone at 8.4 Re, 6.1 MLT and 61.1 MLAT. A magnetic signature was nearly simultaneously observed at about 0104 UT at the POLAR and Geotail spacecraft. The Geotail spacecraft entered from the magnetosphere into the magnetosheath. Particle density increases were observed on WIND and Geotail, but not on POLAR. Two instruments on the Polar spacecraft (TIDE and TIMAS) actually observed a slight reduction in energy, density and temperature. The UV aurora shows a dawnside intensification. The shock wave did not cause an auroral substorm and therefore was not geoeffective.

Direct imaging of the magnetosphere by the IMAGE spacecraft will be supplemented by observation of the global aurora, the footprint of magnetospheric regions. To assure the simultaneity of these observations and the measurement of the magnetospheric background neutral gas density, the IMAGE satellite instrument complement includes three Far Ultraviolet (FUV) instruments. In the wavelength region 120-190 nm, a downward-viewing auroral imager is only minimally contaminated by sunlight, scattered from clouds and ground, and radiance of the aurora observed in a nadir viewing geometry can be observed in the presence of the high-latitude dayglow. The Wideband Imaging Camera (WIC) will provide broad band ultraviolet images of the aurora for maximum spatial and temporal resolution by imaging the LBH N2 bands of the aurora. The Spectrographic Imager (SI), a monochromatic imager, will image different types of aurora, filtered by wavelength. By measuring the Doppler-shifted Ly-α, the proton-induced component of the aurora will be imaged separately. Finally, the GEO instrument will observe the distribution of the geocoronal emission, which is a measure of the neutral background density source for charge exchange in the magnetosphere. The FUV instrument complement looks radially outward from the rotating IMAGE satellite and, therefore, it spends only a short time observing the aurora and the Earth during each spin. Detailed descriptions of the WIC, SI, GEO, and their individual performance validations are discussed in companion papers. This paper summarizes the system requirements and system design approach taken to satisfy the science requirements. One primary requirement is to maximize photon collection efficiency and use efficiently the short time available for exposures. The FUV auroral imagers WIC and SI both have wide fields of view and take data continuously as the auroral region proceeds through the field of view. To minimize data volume, multiple images are taken and electronically co-added by suitably shifting each image to compensate for the spacecraft rotation. In order to minimize resolution loss, the images have to be distortion-corrected in real time for both WIC and SI prior to co-adding. The distortion correction is accomplished using high speed look up tables that are pre-generated by least square fitting to polynomial functions by the on-orbit processor. The instruments were calibrated individually while on stationery platforms, mostly in vacuum chambers as described in the companion papers. Extensive ground-based testing was performed with visible and near UV simulators mounted on a rotating platform to estimate their on-orbit performance. The predicted instrument system performance is summarized and some of the preliminary data formats are shown.

Substorms are often observed to occur when the interplanetary magnetic field (IMF) turns northward at the end of intervals of southward IMF. Despite the significant correlation between northward turnings and substorms, a direct causal relationship between northward turnings and substorms has not been demonstrated. If such a causal relationship exists, then we should be able to predict that substorms will occur within a particular interval following the observation of a northward turning in the IMF. We have searched Wind IMF data and identified 16 strong northward turnings that following intervals of steady, southward IMF. To enhance the chances that the selected northward turnings impacted the magnetosphere, we required that each of them be also observed at either Geotail or IMP 8 while the separation of the second spacecraft from Wind was more that 10 RE in the y direction. Additionally, we required that either the second satellite was on the opposite side of the y = 0 plane from Wind or that one of the satellites was near y = 0. These two spacecraft observations also allowed us to more accurately predict the arrival times of the northward turnings at the Earth than we could by using data only from one spacecraft. Of the predicted substorms, 10 predictions were clearly successful to within ±8 min. Five predictions failed, but these failures reveal important new criteria that must be satisfied for a northward turning to cause a substorm. Three of the failures were caused by an increase in |ByGSM| that occurred simultaneously with the northward turning. This suggests that the triggering is associated with sharp reductions in the magnetospheric electric field, since increases in |ByGSM| negate the convection reduction associated with northward turnings. Two of the failures occurred for cases with the weakest southward IMF preceding the northward turning, which improves our criteria for the strength of the southward IMF that must precede a substorm. The final northward turning resulted in unusual auroral activity. These results establish the predictability of substorms following sharp northward turnings of the IMF and demonstrate that a direct causal relationship between northward turnings and substorm onset exists.

We present the analysis of a coordinated set of observations from the POLAR ultraviolet imager (UVI), ground magnetometers, incoherent scatter radar, solar wind monitors, and the DMSP satellite, focused on a traveling convection vortex (TCV) event on July 24, 1996. Starting at approximately 1036 UT, ground magnetometers in Greenland and eastern Canada observe pulsations consistent with the passing overhead of a series of TCV field-aligned current pairs. Azimuthal scans by the Sondrestrom incoherent scatter radar located near Kangerlussuaq (formerly Sondrestrom), Greenland, at this time show strong modulation in the strength and direction of ionospheric plasma flow. The magnetometer pulsations grow in magnitude over the next hour, peaking in intensity at 1137 UT. Images from the UVI instrument show a localized intensification of auroral emissions over central and western Greenland at 1139 UT. Subsequent images show the intensification grow in strength and propagate westward (tailward) until approximately 1158 UT, at which time the intensification fades, These observations are consistent with the westward passage of four pairs of TCVs over central Greenland. The intensification of auroral emissions at 1139 UT is associated with the leading vortex of the fourth TCV pair, thought to be the result of an upward field-aligned current. The modulated flow observed by the radar is the result of the strong electric fields associated with the field-aligned current systems responsible for the impulsive TCV as they pass through the field of view of the radar. Measurements taken in the solar wind by the Wind spacecraft suggest that a pressure change triggers the onset of TCV activity. A subsequent sudden change in the orientation of the interplanetary magnetic field produces a hot flow anomaly which forms at the bow shock. We believe that the interaction of the hot flow anomaly with the magnetopause intensified the fourth TCV pair and. produced the associated auroral brightening. DMSP particle data indicate that the TCVs occur on field lines which map to the boundary plasma sheet-low latitude boundary layer interface. The ground observations associated with the hot flow anomaly are the first of their kind and provide a mechanism to tie an interplanetary magnetic field orientation change into the existing theory that TCVs result from a deformation of the magnetopause.

The Geospace Dynamics Observatory (GDO) mission observes the near-Earth region in space called Geospace with unprecedented resolution, scale and sensitivity. At a distance of 60 Earth Radii (Re) in a near-polar circular orbit and a approx. 27-day period, GDO images the earth's full disk with (1) a three-channel far ultraviolet imager, (2) an extreme ultraviolet imager of the plasmasphere, and (3) a spectrometer in the near to far ultraviolet range that probes any portion of the disk and simultaneously observes the limb. The exceptional capabilities of the GDO mission include (1) unprecedented improvement in signal to noise for globalscale imaging of Earth's space environment that enable changes in the Earth's space environment to be resolved with orders of magnitude higher in temporal and spatial resolution compared to existing data and other approaches, and (2) unrivaled capability for resolving the temporal evolution, over many days, in local time or latitude with a continuous view of Earth's global-scale evolution while simultaneously capturing the changes at scales smaller than are possible with other methods. This combination of new capabilities is a proven path to major scientific advances and discoveries. The GDO mission (1) has the first full disk imagery of the density and composition variability that exist during disturbed "storm" periods and the circulation systems of the upper atmosphere, (2) is able to image the ionosphere on a global and long time scale basis, (3) is able to probe the mechanisms that control the evolution of planetary atmospheres, and (4) is able to test our understanding of how the Earth is connected to the Sun. This paper explores the optical and technical aspects of the GDO mission and the implementation strategy. Additionally, the case will be made that GDO addresses a significant portion of the priority mission science articulated in the recent Solar and Space Physics Decadal Survey.

The aurorae are the result of collisions with the atmosphere of energetic particles that have their origin in the solar wind, and reach the atmosphere after having undergone varying degrees of acceleration and redistribution within the Earth's magnetosphere. The global scale phenomenon represented by the aurorae therefore contains considerable information concerning the solar-terrestrial connection. For example, by correctly measuring specific auroral emissions, and with the aid of comprehensive models of the region, we can infer the total energy flux entering the atmosphere and the average energy of the particles causing these emissions. Furthermore, from these auroral emissions we can determine the ionospheric conductances that are part of the closing of the magnetospheric currents through the ionosphere, and from these we can in turn obtain the electric potentials and convective patterns that are an essential element to our understanding of the global magnetosphere-ionosphere-thermosphere-mesosphere. Simultaneously acquired images of the auroral oval and polar cap not only yield the temporal and spatial morphology from which we can infer activity indices, but in conjunction with simultaneous measurements made on spacecraft at other locations within the magnetosphere, allow us to map the various parts of the oval back to their source regions in the magnetosphere. This paper describes the Ultraviolet Imager for the Global Geospace Sciences portion of the International Solar-Terrestrial Physics program. The instrument operates in the far ultraviolet (FUV) and is capable of imaging the auroral oval regardless of whether it is sunlit or in darkness. The instrument has an 8° circular field of view and is located on a despun platform which permits simultaneous imaging of the entire oval for at least 9 hours of every 18 hour orbit. The three mirror, unobscured aperture, optical system (f/2.9) provides excellent imaging over this full field of view, yielding a per pixel angular resolution of 0.6 milliradians. Its FUV filters have been designed to allow accurate spectral separation of the features of interest, thus allowing quantitative interpretation of the images to provide the parameters mentioned above. The system has been designed to provide ten orders of magnitude blocking against longer wavelength (primarily visible) scattered sunlight, thus allowing the first imaging of key, spectrally resolved, FUV diagnostic features in the fully sunlit midday aurorae. The intensified-CCD detector has a nominal frame rate of 37 s, and the fast optical system has a noise equivalent signal within one frame of ∼ 10R. The instantaneous dynamic range is >1000 and can be positioned within an overall gain range of 104, allowing measurement of both the very weak polar cap emissions and the very bright aurora. The optical surfaces have been designed to be sufficiently smooth to permit this dynamic range to be utilized without the scattering of light from bright features into the weaker features. Finally, the data product can only be as good as the degree to which the instrument performance is characterized and calibrated. In the VUV, calibration of an an imager intended for quantitative studies is a task requiring some pioneering methods, but it is now possible to calibrate such an instrument over its focal plane to an accuracy of ±10%. In summary, very recent advances in optical, filter and detector technology have been exploited to produce an auroral imager to meet the ISTP objectives.

The response of two-phase droplets to intense radiant heating is studied to determine the incident power that is required for causing explosive boiling in the liquid phase. The droplets studied consist of strongly absorbing coal particles dispersed in a weakly absorbing water medium. Experiments are performed by confining droplets (radii of 37, 55, and 80 microns) electrodynamically and irradiating them from two sides with pulsed laser beams. Emphasis is placed on the transition region from accelerated droplet vaporization to droplet superheating and explosive boiling. The time scale observed for explosive boiling is more than 2 orders of magnitude longer than published values for pure liquids. The delayed response is the result of energy transfer limitations between the absorbing solid phase and the surrounding liquid.

The National Aeronautics and Space Administration (NASA) is launching a bold and ambitious new space initiative. A significant part of this new initiative includes exploration of new worlds, the development of more innovative technologies, and expansion our presence in the solar system. A common theme to this initiative is the exploration of space beyond Low Earth Orbit (LEO). As currently organized, NASA does not have an Agency-level office that provides coordination of space environment research and development. This has contributed to the formation of a gap between spaceflight environments knowledge and the application of this knowledge for multi-program use. This paper outlines a concept to establish a NASA-level Applied Spaceflight Environments (ASE) office that will provide coordination and funding for sustained multi-program support in three technical areas that have demonstrated these needs through customer requests. These technical areas are natural environments characterization and modeling, materials and systems analysis and test, and operational space environments modeling and prediction. This paper will establish the need for the ASE, discuss a concept for organizational structure and outline the scope in the three technical areas

Purpose Midline sternotomy remains the preferred technique for access in cardiac surgery. Application of steel wires has been the preferred method of closure. Because of associated complications, such as superficial and deep infections, as well as bony nonunion complications, an alternative technique is being proposed. The purpose of this study is to evaluate results of a new device for sternal closure. Description The Sternal Talon (KLS Martin Group, Jacksonville, FL), a lightweight titanium closure device is designed to encircle the sternum, thus yielding a stable closure by effectively distributing the strength of closure over the entire length of the sternotomy. After multiple strength tests demonstrated its superiority over wires, and cadaver tests confirmed its ease of placement, the Food and Drug Administration recently approved the device for its unrestricted use. Eight institutions were chosen to perform initial placements. Patient selection was limited to patients at high risk for sternotomy complications. Evaluation In 42 patients who underwent placement of the Sternal Talon (KLS Martin Group) after sternotomy, no wound infections or dehiscence, nonunions, or returns to the operating room were observed. Three postoperative deaths were reported, none of which were device related. The device is magnetic resonance imaging compatible and there are no reported problems with computed tomographic scatter or chest roentgenogram visualization. Conclusions These initial cases prove the safety and efficacy of the Sternal Talon device for sternum closure in high-risk patients and may be regarded as an alternative to conventional wire closure. Future prospective studies are warranted to prove the superiority of the device in terms of long-term stability and sternum union rates, as well as decreased infection rates specifically in the high-risk patient population undergoing sternotomy.

It is well known since the Apollo missions that the lunar surface is covered with a thick layer of micron size dust grains with unusually high adhesive characteristics. The dust grains observed to be levitated and transported on the lunar surface are believed to have a hazardous impact on the robotic and human missions to the Moon. The observed dust phenomena are attributed to the lunar dust being charged positively during the day by UV photoelectric emissions, and negatively during the night by the solar wind electrons. The current dust charging and the levitation models, however, do not fully explain the observed phenomena, with the uncertainty of dust charging processes and the equilibrium potentials of the individual dust grains. It is well recognized that the charging properties of individual dust grains are substantially different from those determined from measurements made on bulk materials that are currently available. An experimental facility has been developed in the Dusty Plasma Laboratory at MSFC for investigating the charging and optical properties of individual micron/sub-micron size positively or negatively charged dust grains by levitating them in an electrodynamic balance in simulated space environments. In this paper, we present the laboratory measurements on charging of Apollo 17 individual lunar dust grains by a low energy electron beam. The charging rates and the equilibrium potentials produced by direct electron impact and by secondary electron emission process are discussed.

Far ultraviolet (FUV) images of Earth from space have proven invaluable in revealing contextual phenomena associated with space weather in the high latitude auroral regions and, more recently with TIMED and IMAGE in the mid and equatorial regions. Images of this nature can be used to investigate compelling questions associated with the interaction of the ionosphere/mesosphere-magnetosphere-solar wind. Three such questions are: 1. What are the critical time and spatial scales that determine the coupling between the magnetosphere and ionosphere? 2. What are the sources and characteristics of ionospheric variability? 3. How does the configuration of the magnetosphere change as a function of internal boundary conditions established by the mesosphere/ionosphere and the external driving conditions of the solar wind? Observations that lead to quantitative analyses are required to significantly advance the state of knowledge with regard to the affects of space weather and the interaction between and within these regions of Geospace. Current available image data sets are sufficient for qualitative analysis and morphological investigations, and while quantitative analyses are possible, they are difficult and limited to few events at best. In order to qualitatively access the time, spatial, and causal phenomena on global scales, simultaneous images of various FUV emissions with a combination of better spatial, temporal and spectral resolution and sensitivity than currently available is required. We present an instrument concept that is being developed to improve the spatial, temporal and spectral resolution and sensitivity needed to perform the quantitative analysis that enable significant advancement in our understanding of the impact of space weather on Geospace. The approach is to use the self-filtering concept that combines the imaging and filtering functions and thus reduces the size of the 4-mirror off-axis optical system. The optical and filter design will de described and results of preliminary breadboard tests will be provided.

The processes and mechanisms involved in the rotation and alignment of interstellar dust grains have been of great interest in astrophysics ever since the surprising discovery of the polarization of starlight more than half a century ago. Numerous theories, detailed mathematical models and numerical studies of grain rotation and alignment with respect to the Galactic magnetic field have been presented in the literature. In particular, the subject of grain rotation and alignment by radiative torques has been shown to be of particular interest in recent years. However, despite many investigations, a satisfactory theoretical understanding of the processes involved in grain rotation and alignment has not been achieved. As there appears to be no experimental data available on this subject, we have carried out some unique experiments to illuminate the processes involved in rotation of dust grains in the interstellar medium. In this paper we present the results of some preliminary laboratory experiments on the rotation of individual micron/submicron size nonspherical dust grains levitated in an electrodynamic balance evacuated to pressures of approximately 10(exp -3) to 10(exp -5) torr. The particles are illuminated by laser light at 5320 Angstroms, and the grain rotation rates are obtained by analyzing the low frequency (approximately 0-100 kHz) signal of the scattered light detected by a photodiode detector. The rotation rates are compared with simple theoretical models to retrieve some basic rotational parameters. The results are examined in the light of the current theories of alignment.

[1] The timescales and phases of auroral substorm activity are quantified in this study using the hemispheric power computed from Polar Ultraviolet Imager (UVI) observations. With this approach we are able to determine substorm phase self consistently from the UVI optical measurements without needing any ancillary metrics for auroral activity. This technique also allows us to combine a quantitative measurement of substorm timescales with the qualitative description of auroral morphology during each event. We show how the characteristics of substorms vary with IMF BZ orientation and season for several hundred substorm events. Substorm intensity, as measured by the rate of energy deposition by electron precipitation, exhibits greater variation with IMF BZ orientation than with season. The timescale of substorm expansion shows comparable variation with both IMF BZ orientation and season. On the other hand, substorm recovery times vary more strongly with season than with IMF BZ direction. The recovery time for substorm activity is well ordered by whether or not the nightside auroral region is sunlit: substorms occurring in the winter and equinox periods have similar recovery timescales which are both roughly a factor of two longer than that for summer when the auroral oval is sunlit. However, IMF BZ orientation is shown to have a strong modulating effect on both substorm expansion and recovery timescales during the summer. The winter-summer asymmetries in the aurora described by previous studies are more completely explained by the seasonal variations of substorm recovery timescales characterized in this work. Our results support the hypothesis that the ionosphere plays an active role in governing the dynamics of the aurora.

An intense dayside proton aurora was observed by Imager for Magnetopause-to- Aurora Global Exploration Far Ultra-Violet imager (IMAGE FUV) for an extensive period of northward interplanetary magnetic field (IMF) on 17 and 18 September 2000. This aurora partially coincided with the auroral oval and intruded farther poleward into the polar cap, and it showed longitudinal motions in response to IMF By variation. Intense magnetosheath-like electron and ion precipitations have been simultaneously detected by Defense Meteorological Satellite Program (DMSP) above the poleward portion of the high-latitude dayside aurora. They resemble the typical plasmas observed in the low-altitude cusp. However, less intense electrons and more energetic ions were detected over the equatonvard part of the aurora. These plasmas are closer to the low-latitude boundary layer (LLBL) plasmas. Under strongly northward IMF, global ionospheric convection derived from Super Dual Auroral Radar Network (SuperDARN) radar measurements showed a four-cell pattern with sunward convection in the middle of the dayside polar cap and the dayside aurora corresponded to two different convection cells. This result further supports two source regions for the aurora. The cusp proton aurora is on open magnetic field lines convecting sunward whereas the LLBL proton aurora is on closed field lines convecting antisunward. These IMAGE, DMSP, and SuperDARN observations reveal the structure and dynamics of the aurora and provide strong evidence for magnetic merging occurring at the high-latitude magnetopause poleward from the cusp. This merging process was very likely quasi-stationary.

Measurements of electromagnetic radiation pressure have been made on individual silica (SiO2) particles levitated in an electrodynamic balance. These measurements were made by inserting single charged particles of known diameter in the 0.2 micron to 6.82 micron range and irradiating them from above with laser radiation focused to beam-widths of approx. 175-400 micron, at ambient pressures approx. 10(exp -3) to 10(exp -4) torr. The downward displacement of the particle due to the radiation force is balanced by the electrostatic force indicated by the compensating dc potential applied to the balance electrodes, providing a direct measure of the radiation force on the levitated particle. Theoretical calculations of the radiation pressure with a least-squares fit to the measured data yield the radiation pressure efficiencies of the particles, and comparisons with Mie scattering theory calculations provide the imaginary part of the refractive index of silica and the corresponding extinction and scattering efficiencies.

NASA has initiated the Living with a Star Program (LWS) to develop the scientific understanding to address the aspects of the Connected Sun-Earth system that affect life and society. A goal of the program is to bridge the gap between science, engineering, and user application communities. This will enable future science, operational, and commercial objectives in space and atmospheric environments by improving engineering approaches to the accommodation and/or mitigation of the effects of solar variability on technological systems. Three program elements are the Science Missions; a Theory, Modeling, and Data Analysis program; and a Space Environment Testbeds program. Because many of the effects of solar variability on humanity are observed in Geospace regions of space, the science research for all three elements of the LWS Program have significant components in Geospace regions.

The Far Ultraviolet Wideband Imaging Camera (WIC) complements the magnetospheric images taken by the IMAGE satellite instruments with simultaneous global maps of the terrestrial aurora. Thus, a primary requirement of WIC is to image the total intensity of the aurora in wavelength regions most representative of the auroral source and least contaminated by dayglow, have sufficient field of view to cover the entire polar region from spacecraft apogee and have resolution that is sufficient to resolve auroras on a scale of 1 to 2 latitude degrees. The instrument is sensitive in the spectral region from 140-190 nm. The WIC is mounted on the rotating IMAGE spacecraft viewing radially outward and has a field of view of 17° in the direction parallel to the spacecraft spin axis. Its field of view is 30° in the direction perpendicular to the spin axis, although only a 17° x 17° image of the Earth is recorded. The optics was an all-reflective, inverted Cassegrain Burch camera using concentric optics with a small convex primary and a large concave secondary mirror. The mirrors were coated by a special multi-layer coating, which has low reflectivity in the visible and near UV region. The detector consists of a MCP-intensified CCD. The MCP is curved to accommodate the focal surface of the concentric optics. The phosphor of the image intensifier is deposited on a concave fiberoptic window, which is then coupled to the CCD with a fiberoptic taper. The camera head operates in a fast frame transfer mode with the CCD being read approximately 30 full frames (512 x 256 pixel) per second with an exposure time of 0.033 s. The image motion due to the satellite spin is minimal during such a short exposure. Each image is electronically distortion corrected using the look up table scheme. An offset is added to each memory address that is proportional to the image shift due to satellite rotation, and the charge signal is digitally summed in memory. On orbit, approximately 300 frames will be added to produce one WIC image in memory. The advantage of the electronic motion compensation and distortion correction is that it is extremely flexible, permitting several kinds of corrections including motions parallel and perpendicular to the predicted axis of rotation. The instrument was calibrated by applying ultraviolet light through a vacuum monochromator and measuring the absolute responsivity of the instrument. To obtain the data for the distortion look up table, the camera was turned through various angles and the input angles corresponding to a pixel matrix were recorded. It was found that the spectral response peaked at 150 nm and fell off in either direction. The equivalent aperture of the camera, including mirror reflectivities and effective photocathode quantum efficiency, is about 0.04 cm2. Thus, a 100 Rayleigh aurora is expected to produce 23 equivalent counts per pixel per 10 s exposure at the peak of instrument response.

This special issue of the Journal of' Atmospheric and Solar-Terrestrial Physics is a compilation of 23 papers presented at The 2004 Huntsville Modeling Workshop: Challenges to Modeling thc San-Earth System held in Huntsville, AB on October 18-22, 2004. The title of the workshop appropriately captures the theme of what was presented and discussed by the 120 participants. Currently, end-to-end modeling of the Sun-Earth system is a major goal of the National Space Weather and NASA living with a star (LWS) programs. While profound advances have been made in modeling isolated regions of the Sun-Earth system, minimal progress has been achieved in modeling the end-to-end system. The transfer of mass, energy and momentum through the coupled Sun-Earth system spans a wide range of scales inn time and space. The uncertainty in the underlying physics responsible for coupling contiguous regions of the Sun-Earth system is recognized as a significant barrier to progress

A laboratory investigation has been developed to experimentally study the interaction of micron sized particles with plasmas and electromagnetic radiation. The intent is to investigate under what conditions particles of various compositions and sizes become charged, or discharged, while exposed to an electron beam. Primary emphasis in this report is on secondary emission of electrons. Preliminary results are presented.

The dominant charging processes in various astrophysical environments are considered to be by photoelectric emissions with radiation from nearby stars and secondary electron emissions (SEE) by impact of electrons in a medium with sufficiently high energies. The charging of bulk materials with planar surfaces by SEE with electron impact appears to be well understood with theoretical expressions as well as by experimental techniques. However, the charging of submicron/micron-size dust grains by SEE with sufficiently high-energy electrons is a complex process, and is a function of electron energies, the electron current, and the grain size, and the charge or the surface potential. Development of viable theoretical models and acquisition of experimental data for charging properties of micron-size dust grains are still in the early stages. This paper focuses on SEE charging properties of individual micron-size dust grains by low-energy electron impact, obtained from laboratory measurements on an experimental facility based on an electrodynamic balance. The measurements of SEE yields of positively charged dust grains indicate the yields increase with decreasing grain size and the equilibrium surface potentials showing generally linear size dependence. These experimental results are generally in agreement with several independent experimental and analytical model studies in the literature, with the exception of a recently published paper which is in fundamental conflict with our studies as well as with several other experimental and theoretical studies. The sources and causes of this conflict are critically examined and discussed in this paper.

During the week of October 4-9,2009, about 160 participants from 19 countries met at the Itamambuca resort area of Ubatuba, Sao Paulo, Brazil to discuss the "Influence of solar variability on geophysical and heliospheric phenomena" Conference, organized by the International Living With a Star (ILWS) Program of NASA and by the National Institute of Space Research (INPE) of Brazil. This special issue collects 38 papers from that Conference, with 3 papers dealing with solar topics, 12 with interplanetary and cosmic rays,12 with magnetospheric, 9 with the low-latitude ionosphere and 2 with solar terrestrial system and climate. Furthermore six of the review papers presented at that Conference are being published in a special issue of the SpaceScience Reviews journal. The combined ensemble of papers describes the complex series of phenomena that link the Sun to the Earth.

New advances in VUV thin film filter technology have been made using filter designs with multilayers of materials such as Al2O3, BaF2, CaF2, HfO2, LaF3, MgF2, and SiO2. Our immediate application for these filters will be in an imaging system to be flown on a satellite where a 2 X 9 R(sub E) orbit will expose the instrument to approximately 275 krads of radiation. In view of the fact that no previous studies have been made on potential radiation damage of these materials in the thin film format, we report on such an assessment here. Transmittances and reflectances of BaF2, CaF2, HfO2, LaF3, MgF2, and SiO2 thin films on MgF2 substrates, Al2O3 thin films on fused silica substrates, uncoated fused silica and MgF2, and four multilayer filters made from these materials were measured from 120 nm to 180 nm before and after irradiation by 250 krads from a Co-60 gamma radiation source. No radiation-induced losses in transmittance or reflectance occurred in this wavelength range. Additional postradiation measurements from 160 nm to 300 nm indicated a 3 - 5% radiation-induced absorption near 260 nm in some of the samples with MgF2 substrates. From these measurements it is concluded that far ultraviolet filters made from the materials tested should experience less that 5% change from exposure to up to 250 krads of high energy radiation in space applications.

The far ultraviolet (FUV) imager for the International Solar-Terrestrial Physics (ISTP) mission is designed to image four features of the aurora: O I lines at 130.4 nm and 135.6 nm and the N2 Lyman-Birge-Hopfield (LBH) bands between 140 nm-160 nm (LBH long) and 160 nm-180 nm (LBH long). We report the design and fabrication of narrow-band and broadband filters for the ISTP FUV imager. Narrow-band filters designed and fabricated for the O I lines have a bandwidth of less than 5 nm and a peak transmittance of 22.3 and 29.6 percent at 130.4 nm and 135.6 nm, respectively. Broadband filters designed and fabricated for LBH bands have the transmittance greater than 40 percent for LBH short and close to 60 percent for LBH long. Blocking of out-of-band wavelengths for all filters is better than 0.001 percent with the transmittance at 121.6 nm of less than 10 exp -6 percent.

The hypothesis that an infusion of recombinant tissue-type plasminogen activator (rt-PA) maintained for up to 24 hours could prevent reocclusion after early coronary patency had been established was evaluated in patients with acute myocardial infarction. The rt-PA studied was an investigational double chain rt-PA (Duteplase, Burroughs Wellcome Co.), administered according to body weight. Coronary patency was documented in 139 of 213 patients who had 90-minute angiograms recorded after an initial lytic dose of rt-PA. In these responders a further 90-minute infusion at one third the initial lytic dose was given before assignment to 1 of 4 maintenance dose rates (0.012, 0.024, 0.036, 0.048 MIU/kg/hour) which were continued for the subsequent 9 to 21 hours. The principal end point was the status of the infarct-related coronary artery 12 to 24 hours after the start of therapy, and before termination of rt-PA, in patients with initially patent vessels at 90 minutes. Of the 103 responders with repeat angiograms after a 9 to 21 hour maintenance infusion of rt-PA, a total of 17 (16.5%) patients reoccluded across all doses administered. There was no significant relationship between the maintenance dose rate and the incidence of reocclusion. However, there was strong association between total dose of rt-PA administered and the incidence (16%) of serious or life-threatening bleeding exclusive of surgery. Other factors associated with serious bleeding included low body weight, female gender, and total duration of rt-PA infusion. Reocclusion was independent of the 90-minute Thrombolysis in Myocardial Infarction trial perfusion grade and diameter of infarct vessel. Rethrombosis after establishment of early patency after rt-PA remains a significant problem that is unaffected by sustained rt-PA infusion in doses that can be tolerated.

For decades, the geospace science community has emphasized the importance of solar influences on magnetospheric and ionospheric plasma dynamics, and the consequences of those influences on Earth- and space-based technological systems. In 2000, NASA presented a compelling case for this new research to the United States Congress, which awarded NASAs Space Science Enterprise with a new initiative, Living HHMH with a Star (LWS), with a goal “to better study solar variability and understand its effects on humanity.” The primary goal of LWS is to develop the scientific understanding necessary to enable the U.S. to effectively address those aspects of the connected Sun-Earth system that directly affect life and society. The NASA personnel associated with the Sun-Earth connection theme of the Space Science Enterprise eagerly stepped up to this challenge and began an accelerated activity to define LWS. As part of its definition activities, NASA appointed a panel, the LWS Geospace Mission Definition Team (GMDT), chaired by space physicist Paul Kintner of Cornell University. The panel was composed of scientists from universities, industry and government laboratories, and representatives from both the research and space operations user communities. In a recently released report, it presented recommendations for the science goals and implementation approach for the Geospace Project of the LWS program, a crucial component of the National Space Weather Program.

Photoemission experiments with UV radiation have been performed to investigate the microphysics and charge characteristics of individual isolated dust grains of various compositions and sizes by using the electrodynamic balance facility at NASA Marshall Space Flight Center. Dust particles of 1 - 100 micrometer diameter are levitated in a vacuum chamber at pressures approx. 10(exp -5) torr and exposed to a collimated beam of UV radiation in the 120-300 nanometers spectral range from a deuterium lamp source with a MgF2 window. A monochromator is used to select the UV radiation wavelength with a spectral resolution of 8 nanometers. The electrodynamic facility permits measurements of the charge and diameters of particles of known composition, and monitoring of photoemission rates with the incident UV radiation. Experiments have been conducted on Al2O3 and silicate particles, and in particular on JSC-1 Mars regolith simulants, to determine the photoelectron yields and surface equilibrium potentials of dust particles when exposed to UV radiation in the 120-250 micrometers spectral range. A brief discussion of the experimental procedure, the results of photoemission experiments, and comparisons with theoretical models will be presented.

Global auroral images and plasma sheet ion distributions and magnetic field data are examined for two intervals when the Ultraviolet Imager (UVI) onboard the Polar spacecraft was imaging the entire northern auroral oval and, at the same time, the Wind spacecraft was passing through the near-Earth plasma sheet. On 26 July 1997, UVI recorded a series of brief, localized auroral brightenings known as pseudobreakups. On 27 March 1996, UVI observed several global expansions of auroral activity. Large variations in the magnetic field were observed by the Wind magnetometer, large velocity moments were derived from Wind ion measurements, and ions were accelerated to mega-electron-volt energies during both types of activity. The plasma sheet dynamics appear very similar during these two different types of auroral activities. Closer inspection of the ion distribution functions and energy spectra indicate that the plasma sheet dynamics need to be characterized kinetically.

Advances in vacuum ultraviolet thin-film filter technology have been made through the use of filter designs with multilayers of materials such as Al(2)O(3), BaF(2), CaF(2), HfO(2), LaF(3), MgF(2), and SiO(2). Our immediate application for these filters will be in an imaging system to be flown on a satellite where a 2 × 9 R(E) orbit will expose the instrument to approximately 250 krad of radiation. Because to our knowledge no previous studies have been made on the potential radiation damage of these materials in the thin-film format, we report on such an assessment here. Transmittances and reflectances of BaF(2), CaF(2), HfO(2), MgF(2), and SiO(2) thin films on MgF(2) substrates, Al(2)O(3) thin films on fused-silica substrates, uncoated fused silica and MgF(2), and four multilayer filters made from these materials were measured from 120 to 180 nm beforeand after irradiation by 250 krad from a (60)Co gamma radiation source. No radiation-induced losses in transmittance or reflectance occurred in this wavelength range. Additional postradiation measurements from 160 to 300 nm indicates 2-5% radiation-induced absorption near 260 nm in some of the samples with MgF(2) substrates. From these measurements we conclude that far-ultraviolet filters made from the materials tested should experience less than 5% change from exposure to up to 250 krad of high-energy radiation in space applications.

Imaging of the earth's auroral regions in the ultraviolet provides information on a global scale on the energy flux and characteristics of precipitating particles an on the composition of the atmosphere in which the energy is deposited. The authors report the design of an imager with 0.6-mrad angular resolution over an 8-deg field of view sampled with 39,500 pixels, yielding global auroral coherent imaging from above 6 R[sub E](Earth radii). High-performance filters provide spectrally pure measurements of four key far-UV (FUV) features, with 5 [times] 10[sup [minus]5] out-of-band rejection. Together with a solar blind intensified CCD detector, a net rejection of 10[sup [minus]9] of all out-of-band emissions is achieved. The optical design comprises a three-mirror f/3 system that yields a noise equivalent sensitivity of 10 rayleighs (R) for a 37-s frame rate. The intrascene and interscene dynamic ranges are 1,000 and 10[sup 5], respectively. The optical surface microroughness is less than 2 nm, providing exceptionally low light scattering characteristics, allowing simultaneous observations of very weak and bright emissions. The imager should provide about two orders of magnitude improvement in performance over previous designs.

The far ultraviolet (FUV) imager for the International Solar Terrestrial Physics (ISTP) mission is designed to image four features of the aurora: O I lines at 130.4 nm and 135.6 nm and the N2 Lyman-Birge-Hopfield (LBH) bands between 140 nm - 160 nm (LBH long) and 160 nm - 180 nm (LBH long). In this paper we report the design and fabrication of narrow-band and broadband filters for the ISTP FUV imager. Narrow-band filters designed and fabricated for the O I lines have a bandwidth of less than 5 nm and a peak transmittance of 23.9 percent and 38.3 percent at 130.4 nm and 135.6 nm, respectively. Broadband filters designed and fabricated for LBH bands have the transmittance close to 60 percent. Blocking of out-of-band wavelengths for all filters is better than 5x10(exp -3) percent with the transmittance at 121.6 nm of less than 10(exp -6) percent.

An iteration process matching calculated and measured reflectance and transmittance values in the 120-230 nm VUV region is presently used to ascertain the optical constants of bulk MgF2, as well as films of BaF2, CaF2, LaF3, MgF2, Al2O3, HfO2, and SiO2 deposited on MgF2 substrates. In the second part of this work, a design concept is demonstrated for two filters, employing rapidly changing extinction coefficients, centered at 135 nm for BaF2 and 141 nm for SiO2. These filters are shown to yield excellent narrowband spectral performance in combination with narrowband reflection filters.

We report the design and performance of narrowband transmission filters employing the rapidly changing extinction coefficient that is characteristic of BaF(2) and SiO(2) films within certain wavelength intervals in the vacuum ultraviolet. We demonstrate the design concept for two filters centered at 135 nm for BaF(2) and at 141 nm for SiO(2). It is found that these filters provide excellent narrowband spectral performance when combined with narrowband reflection filters. The filter centered at 135 nm has a peak transmittance of 24% and a bandwidth of 4 nm at full width at half-maximum for collimated incident light. The transmittance for lambda(0)/= 130 nm is0.1% and for 138/= lambda(0)/= 230 nm the average transmittance is3%. Another filter centered at 141 nm has a peak transmittance of 25% and a bandwidth of 3.5 nm.

Quinidine pharmacokinetics (half-life, volume of distribution, and clearance) as well as protein binding were evaluated following a single 200 mg. oral dose of quinidine sulfate in eight control patients, in eight patients with moderate to severe cirrhosis, and in seven patients receiving 40 to 400 mg./day of propranolol. Patients with cirrhosis had a significantly longer quinidine half-life (9 +/- 1 hr; p less than .01) when compared to control patients (6 +/- 0.5h). This was not related to a reduced quinidine clearance rate but rather to an increase in quinidine volume of distribution (4.1 +/- .4 L./Kg. in cirrhotic patients vs 2.6 +/- 1 L./Kg. in control patients; p less than .01). Abnormal quinidine binding (greater than 25 per cent unbound fraction) was noted in seven of the eight cirrhotic patients. In contrast, patients receiving propranolol had a normal quinidine half-life of 6 +/- 0.5 hr. However, these patients had a significantly reduced quinidine clearance (3.3 +/- .7 ml./min./Kg. vs. 5.3 +/- .5 ml./min./Kg. in controls; p less than .05) and higher peak concentrations (1.25 +/- .20 micrograms/ml. vs. .80 +/- .5 micrograms/ml. in controls; p less than .05). Therefore in patients receiving propranolol, quinidine levels may be higher than expected shortly after dosage, and therefore a potential for transient toxicity exists in these patients. Maintenance quinidine dosage may have to be reduced in patients with moderate to severe hepatic cirrhosis, but not in patients receiving propranolol. Total quinidine concentration measurement underestimate free quinidine concentrations in most cirrhotic patients.

To evaluate whether bepridil once a day provides effective antianginal therapy during extended use, a placebo-controlled withdrawal study was conducted in 33 patients with chronic stable angina. Each patient studied had previously had a favorable response to short-term administration of bepridil and had been taking the drug once daily for greater than or equal to 9 months of continuous use. Patients were then randomly assigned to receive either continued bepridil or a placebo substitution once daily during a 4-week, double-blind, parallel-group comparison. Dosage for the bepridil group was constantly maintained for each patient at a level observed to be clinically effective. The study consisted of a comparison of angina frequency and nitroglycerin tablet consumption obtained from patient diaries and results from maximal-graded multistage treadmill tests. Patients randomized to continue receiving bepridil remained stable in terms of angina frequency and exercise performance. Discontinuation of long-term bepridil significantly increased angina frequency and nitroglycerin tablet consumption and reduced exercise capacity. Four patients (24%), all receiving placebo treatment, had increases in angina frequency and had the study terminated. Bepridil was reinstituted in these patients with resolution of symptoms and no untoward effects. The results of this placebo-controlled, double-blind, randomized study confirm that bepridil continues to provide antianginal benefit during long-term administration.

A new method for determining absolute left ventricular (LV) volume from equilibrium gated blood pool images was validated in 36 patients by comparing gated blood pool (GBP) imaging with contrast ventriculography (CV) using both Simpson's rule (SR) and area-length (AL) calculations. The technique is geometry-independent and is the first to correct for tissue attenuation with use of an in vivo point source. An orally administered capsule containing 1 to 2 mCi of technetium-99m (Tc-99m) sulfur colloid is used for this purpose. Left ventricular volumes are determined by dividing attenuation and background-corrected count rates obtained from semiautomated LV regions of interest by the count rate per milliliter from a blood sample. The correlation between GBP and CV (SR) was 0.96 (CV [SR] = 0.99 GBP + 1.32 ml; standard error of the estimate [SEE] = 21.2 ml) for diastole and 0.97 (CV [SR] = 0.93 GBP - 0.03 ml; SEE = 11.9 ml) for systole. The correlation between GBP and CV (AL) was 0.92 (CV [AL] = 0.90 GBP + 16.72 ml; SEE = 27.8 ml) for diastole and 0.95 (CV [AL] = 0.87 GBP + 4.56 ml; SEE = 14.4 ml) for systole. The method is noninvasive and can be performed easily as part of routine gated blood pool imaging and analysis.

In summary, we have examined the response to arterial vasoconstriction in an in vitro coronary artery preparation. Without a preexisting stenosis, arterial vasoconstriction had minimal hemodynamic effects. Similarly, with a stenosis created by a circumferential snare, arterial vasoconstriction had minimal hemodynamic effects. In striking contrast, with a stenosis created by intraluminal obstruction, arterial vasoconstriction dramatically increased the hemodynamic severity of the stenosis. The use of an intraluminal obstruction provides a useful animal model for examining hemodynamics in coronary artery disease and has provided some insight into the effects of vasoconstriction on coronary artery hemodynamics. Obviously, this is an experimental study, and care must be taken in extrapolating these results to diseased human coronary arteries.

The effects of chronic pressure overload hypertrophy on myocardial blood flow and capillary density was measured in the feline left ventricle. Myocardial hypertrophy was produced by and 84% banding constriction of the ascending aorta 2.8 +/- 1.2 months before the experiments. In seven cats with aortic constriction, cardiac hypertrophy produced a 40% increase in left ventricular mass. Seven cats served as normals. Our findings show that, in chronic pressure overload hypertrophy, coronary blood flow at control (resting) levels is increased compared with normals. In both normal and hypertrophy cats endocardial/epicardial flow ratios were equal at the control level. In the hypertrophied hearts, coronary reserve, measured as the percentage increase in myocardial blood flow from control to near maximal flow during adenosine infusion, was reduced. In the hypertrophy group a shift in the transmural distribution of blood flow in the left ventricle was noticed, as indicated by a reduced endo/epi flow ratio, during adenosine infusion. A decreased capillary density in hypertrophy, most marked in endocardial tissue regions, was demonstrated by this study. These findings indicate that capillary growth does not parallel myofibre growth in the endocardium of pressure overload hypertrophied left ventricles. The resultant anatomical imbalance causes a compromise of flow reserve in the endocardium, making this region vulnerable to ischaemia.

Subendocardial, nontransmural, or non-Q-wave myocardial infarction (NQMI) carries a serious prognosis. Many previous studies of NQMI include only patients without new Q waves at the time of infarction. Since the site of transmural MI (by Q waves) has implications concerning extent of coronary disease (CAD) and left ventricular (LV) dysfunction, we wondered what the extent of CAD and LV dysfunction is among acute MI patients who have neither new nor old Q waves. Furthermore, we sought to determine whether ST-T wave patterns or resting LV ejection fraction (EF), alone or combined, could separate NQMI patients with significant CAD from those with normal or nearly normal coronaries. Therefore, we retrospectively examined angiographic and electrocardiographic data in 55 symptomatic patients with NQMI. ST-T wave patterns on admission were classified as either ischemic (transient ST elevation, persistent horizontal ST depression, or persistent deep T wave inversion) or nonspecific. Eleven patients (20%) had normal or nearly normal coronaries (N); ten patients (18%) had one, seven patients (13%) had two, and 19 patients (34%) had three vessel CAD; eight patients (15%) had left main (LM) disease. Six of the 11 N patients had ergonovine tests and all six were negative. Segmental LV wall motion abnormalities (WMA) were commonly observed; however, diffuse LVWMA were present only among patients with three vessel and LM disease. EF was below 0.50 in 48% of patients with three vessel or LM disease. Although ischemic ST-T wave patterns were more common (P < 0.05) among patients with significant CAD than among N patients, neither the ST-T wave pattern nor EF, alone or in combination, allowed confident separation of N patients from significant CAD patients. We conclude 1) A large proportion of NQMI patients have LM disease, three vessel disease, or normal or nearly normal coronaries. 2) Despite the absence of Q waves, LV dysfunction is common and the degree of LV impairment is worse among patients with more extensive CAD. 3) NQMI patients who may have normal or nearly normal coronaries cannot be reliably separated from NQMI patients with significant CAD on the basis of ST-T wave patterns or resting LVEF. 4) Coronary angiography appears warranted to assess the extent of CAD in symptomatic NQMI patients.