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1. Overcoming challenges in the economic evaluation of interventions to optimise antibiotic use

Author: Laurence S. J. Roope, Liz Morrell, James Buchanan, Alice Ledda, Amanda I. Adler, Mark Jit, A. Sarah Walker, Koen B. Pouwels, Julie V. Robotham, Sarah Wordsworth, and on behalf of the STEPUP team
Subjects: Medicine
Abstract: Abstract Bacteria are becoming increasingly resistant to antibiotics, reducing our ability to treat infections and threatening to undermine modern health care. Optimising antibiotic use is a key element in tackling the problem. Traditional economic evaluation methods do not capture many of the benefits from improved antibiotic use and the potential impact on resistance. Not capturing these benefits is a major obstacle to optimising antibiotic use, as it fails to incentivise the development and use of interventions to optimise the use of antibiotics and preserve their effectiveness (stewardship interventions). Estimates of the benefits of improving antibiotic use involve considerable uncertainty as they depend on the evolution of resistance and associated health outcomes and costs. Here we discuss how economic evaluation methods might be adapted, in the face of such uncertainties. We propose a threshold-based approach that estimates the minimum resistance-related costs that would need to be averted by an intervention to make it cost-effective. If it is probable that without the intervention costs will exceed the threshold then the intervention should be deemed cost-effective.
Published: 2024
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2. QALYs and rare diseases: exploring the responsiveness of SF-6D, EQ-5D-5L and AQoL-8D following genomic testing for childhood and adult-onset rare genetic conditions in Australia

Author: Tianxin Pan, You Wu, James Buchanan, and Ilias Goranitis
Subjects: Personal utility, Patient-reported outcome measures, Genomic sequencing, Rare disease, Responsiveness, Computer applications to medicine. Medical informatics, R858-859.7
Abstract: Abstract Background Genomic testing transforms the diagnosis and management of rare conditions. However, uncertainty exists on how to best measure genomic outcomes for informing healthcare priorities. Using the HTA-preferred method should be the starting point to improve the evidence-base. This study explores the responsiveness of SF-6D, EQ-5D-5L and AQoL-8D following genomic testing across childhood and adult-onset genetic conditions. Method Self-reported patient-reported outcomes (PRO) were obtained from: primary caregivers of children with suspected neurodevelopmental disorders (NDs) or genetic kidney diseases (GKDs) (carers’ own PRO), adults with suspected GKDs using SF-12v2; adults with suspected complex neurological disorders (CNDs) using EQ-5D-5L; and adults with dilated cardiomyopathy (DCM) using AQol-8D. Responsiveness was assessed using the standardised response mean effect-size based on diagnostic (having a confirmed genomic diagnosis), personal (usefulness of genomic information to individuals or families), and clinical (clinical usefulness of genomic information) utility anchors. Results In total, 254 people completed PRO measures before genomic testing and after receiving results. For diagnostic utility, a nearly moderate positive effect size was identified by the AQoL-8D in adult DCM patients. Declines in physical health domains masked any improvements in mental or psychosocial domains in parents of children affected by NDs and adult CNDs and DCM patients with confirmed diagnosis. However, the magnitude of the changes was small and we did not find statistically significant evidence of these changes. No other responsiveness evidence related to diagnostic, clinical, and personal utility of genomic testing was identified. Conclusion Generic PRO measures may lack responsiveness to the diagnostic, clinical and personal outcomes of genomics, but further research is needed to establish their measurement properties and relevant evaluative space in the context of rare conditions. Expected declines in the physical health of people experiencing rare conditions may further challenge the conventional application of quality of life assessments.
Published: 2023
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3. Retrospective file review shows limited genetic services fail most patients – an argument for the implementation of exome sequencing as a first-tier test in resource-constrained settings

Author: Emma K. Wiener, James Buchanan, Amanda Krause, Zané Lombard, and for the DDD-Africa Study, as members of the H3Africa Consortium
Subjects: Low- and middle-income countries, Genetic services, Exome sequencing, Developmental disorders, Diagnostic guidelines, Medicine
Abstract: Abstract Background Exome sequencing is recommended as a first-line investigation for patients with a developmental delay or intellectual disability. This approach has not been implemented in most resource-constraint settings, including Africa, due to the high cost of implementation. Instead, patients have limited access to services and testing options. Here, we evaluate the effectiveness of a limited genetic testing strategy and contrast the findings to a conceivable outcome if exome sequencing were available instead. Results A retrospective audit of 934 patient files presenting to a medical genetics clinic in South Africa showed that 83% of patients presented with developmental delay as a clinical feature. Patients could be divided into three groups, representing distinct diagnostic pathways. Patient Group A (18%; mean test cost $131) were confirmed with aneuploidies, following a simple, inexpensive test. Patient Group B (25%; mean test cost $140) presented with clinically recognizable conditions but only 39% received a genetic diagnostic confirmation due to limited testing options. Patient Group C – the largest group (57%; mean test cost $337) – presented with heterogenous conditions and DD, and 92% remained undiagnosed after limited available testing was performed. Conclusions Patients with DD are the largest group of patients seen in medical genetics clinics in South Africa. When clinical features are not distinct, limited testing options drastically restricts diagnostic yield. A cost- and time analysis shows most patients would benefit from first-line exome sequencing, reducing their individual diagnostic odysseys.
Published: 2023
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4. Mixed-methods evaluation of the NHS Genomic Medicine Service for paediatric rare diseases: study protocol [version 2; peer review: 3 approved, 1 approved with reservations]

Author: Saskia C. Sanderson, Lauren Roberts, Cecilia Vindrola-Padros, Sarah L. Wynn, Monica Lakhanpaul, Celine Lewis, Angus Clarke, James Buchanan, Bettina Friedrich, Emma Clement, Melissa Hill, Jillian Hastings-Ward, Anneke M. Lucassen, Ruth Horn, Alexandra Pickard, and Chris Patch
Subjects: genomics, genomic medicine service, rare disease, paediatric, protocol, mixed methods, eng, Medicine
Abstract: Background: A new nationally commissioned NHS England Genomic Medicine Service (GMS) was recently established to deliver genomic testing with equity of access for patients affected by rare diseases and cancer. The overarching aim of this research is to evaluate the implementation of the GMS during its early years, identify barriers and enablers to successful implementation, and provide recommendations for practice. The focus will be on the use of genomic testing for paediatric rare diseases. Methods: This will be a four-year mixed-methods research programme using clinic observations, interviews and surveys. Study 1 consists of qualitative interviews with designers/implementers of the GMS in Year 1 of the research programme, along with documentary analysis to understand the intended outcomes for the Service. These will be revisited in Year 4 to compare intended outcomes with what happened in practice, and to identify barriers and facilitators that were encountered along the way. Study 2 consists of clinic observations (pre-test counselling and results disclosure) to examine the interaction between health professionals and parents, along with follow-up interviews with both after each observation. Study 3 consists of a longitudinal survey with parents at two timepoints (time of testing and 12 months post-results) along with follow-up interviews, to examine parent-reported experiences and outcomes. Study 4 consists of qualitative interviews and a cross-sectional survey with medical specialists to identify preparedness, facilitators and challenges to mainstreaming genomic testing. The use of theory-based and pre-specified constructs will help generalise the findings and enable integration across the various sub-studies. Dissemination: We will disseminate our results to policymakers as findings emerge, so any suggested changes to service provision can be considered in a timely manner. A workshop with key stakeholders will be held in Year 4 to develop and agree a set of recommendations for practice.
Published: 2022
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5. Why do hospital prescribers continue antibiotics when it is safe to stop? Results of a choice experiment survey

Author: Laurence S. J. Roope, James Buchanan, Liz Morrell, Koen B. Pouwels, Katy Sivyer, Fiona Mowbray, Lucy Abel, Elizabeth L. A. Cross, Lucy Yardley, Tim Peto, A. Sarah Walker, Martin J. Llewelyn, and Sarah Wordsworth
Subjects: Antibiotic prescribing, Antibiotic stewardship, Hospitals, Medicine
Abstract: Abstract Background Deciding whether to discontinue antibiotics at early review is a cornerstone of hospital antimicrobial stewardship practice worldwide. In England, this approach is described in government guidance (‘Start Smart then Focus’). However,
Published: 2020
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6. Assessing women's preferences towards tests that may reveal uncertain results from prenatal genomic testing: Development of attributes for a discrete choice experiment, using a mixed-methods design.

Author: Jennifer Hammond, Jasmijn E Klapwijk, Sam Riedijk, Stina Lou, Kelly E Ormond, Ida Vogel, Lisa Hui, Emma-Jane Sziepe, James Buchanan, Charlotta Ingvoldstad-Malmgren, Maria Johansson Soller, Eleanor Harding, Melissa Hill, and Celine Lewis
Subjects: Medicine, Science
Abstract: Prenatal DNA tests, such as chromosomal microarray analysis or exome sequencing, increase the likelihood of receiving a diagnosis when fetal structural anomalies are identified. However, some parents will receive uncertain results such as variants of uncertain significance and secondary findings. We aimed to develop a set of attributes and associated levels for a discrete-choice experiment (DCE) that will examine parents' preferences for tests that may reveal uncertain test results. A two phase mixed-methods approach was used to develop attributes for the DCE. In Phase 1, a "long list" of candidate attributes were identified via two approaches: 1) a systematic review of the literature around parental experiences of uncertainty following prenatal testing; 2) 16 semi-structured interviews with parents who had experienced uncertainty during pregnancy and 25 health professionals who return uncertain prenatal results. In Phase 2, a quantitative scoring exercise with parents prioritised the candidate attributes. Clinically appropriate levels for each attribute were then developed. A final set of five attributes and levels were identified: likelihood of getting a result, reporting of variants of uncertain significance, reporting of secondary findings, time taken to receive results, and who tells you about your result. These attributes will be used in an international DCE study to investigate preferences and differences across countries. This research will inform best practice for professionals supporting parents to manage uncertainty in the prenatal setting.
Published: 2022
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7. Mixed-methods evaluation of the NHS Genomic Medicine Service for paediatric rare diseases: study protocol [version 1; peer review: 2 approved, 2 approved with reservations]

Author: Saskia C. Sanderson, Lauren Roberts, Cecilia Vindrola-Padros, Sarah L. Wynn, Monica Lakhanpaul, Celine Lewis, Angus Clarke, James Buchanan, Bettina Friedrich, Emma Clement, Melissa Hill, Jillian Hastings-Ward, Anneke M. Lucassen, Ruth Horn, Alexandra Pickard, and Chris Patch
Subjects: genomics, genomic medicine service, rare disease, paediatric, protocol, mixed methods, eng, Medicine
Abstract: Background: A new nationally commissioned NHS England Genomic Medicine Service (GMS) was recently established to deliver genomic testing with equity of access for patients affected by rare diseases and cancer. The overarching aim of this research is to evaluate the implementation of the GMS during its early years, identify barriers and enablers to successful implementation, and provide recommendations for practice. The focus will be on the use of genomic testing for paediatric rare diseases. Methods: This will be a four-year mixed-methods research programme using clinic observations, interviews and surveys. Study 1 consists of qualitative interviews with designers/implementers of the GMS in Year 1 of the research programme, along with documentary analysis to understand the intended outcomes for the Service. These will be revisited in Year 4 to compare intended outcomes with what happened in practice, and to identify barriers and facilitators that were encountered along the way. Study 2 consists of clinic observations (pre-test counselling and results disclosure) to examine the interaction between health professionals and parents, along with follow-up interviews with both after each observation. Study 3 consists of a longitudinal survey with parents at two timepoints (time of testing and 12 months post-results) along with follow-up interviews, to examine parent-reported experiences and outcomes. Study 4 consists of qualitative interviews and a cross-sectional survey with medical specialists to identify preparedness, facilitators and challenges to mainstreaming genomic testing. The use of theory-based and pre-specified constructs will help generalise the findings and enable integration across the various sub-studies. Dissemination: We will disseminate our results to policymakers as findings emerge, so any suggested changes to service provision can be considered in a timely manner. A workshop with key stakeholders will be held in Year 4 to develop and agree a set of recommendations for practice.
Published: 2021
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8. Public preferences for delayed or immediate antibiotic prescriptions in UK primary care: A choice experiment.

Author: Liz Morrell, James Buchanan, Laurence S J Roope, Koen B Pouwels, Christopher C Butler, Benedict Hayhoe, Sarah Tonkin-Crine, Monsey McLeod, Julie V Robotham, Alison Holmes, A Sarah Walker, Sarah Wordsworth, and STEPUP team
Subjects: Medicine
Abstract: BackgroundDelayed (or "backup") antibiotic prescription, where the patient is given a prescription but advised to delay initiating antibiotics, has been shown to be effective in reducing antibiotic use in primary care. However, this strategy is not widely used in the United Kingdom. This study aimed to identify factors influencing preferences among the UK public for delayed prescription, and understand their relative importance, to help increase appropriate use of this prescribing option.Methods and findingsWe conducted an online choice experiment in 2 UK general population samples: adults and parents of children under 18 years. Respondents were presented with 12 scenarios in which they, or their child, might need antibiotics for a respiratory tract infection (RTI) and asked to choose either an immediate or a delayed prescription. Scenarios were described by 7 attributes. Data were collected between November 2018 and February 2019. Respondent preferences were modelled using mixed-effects logistic regression. The survey was completed by 802 adults and 801 parents (75% of those who opened the survey). The samples reflected the UK population in age, sex, ethnicity, and country of residence. The most important determinant of respondent choice was symptom severity, especially for cough-related symptoms. In the adult sample, the probability of choosing delayed prescription was 0.53 (95% confidence interval (CI) 0.50 to 0.56, p < 0.001) for a chesty cough and runny nose compared to 0.30 (0.28 to 0.33, p < 0.001) for a chesty cough with fever, 0.47 (0.44 to 0.50, p < 0.001) for sore throat with swollen glands, and 0.37 (0.34 to 0.39, p < 0.001) for sore throat, swollen glands, and fever. Respondents were less likely to choose delayed prescription with increasing duration of illness (odds ratio (OR) 0.94 (0.92 to 0.96, p < 0.001)). Probabilities of choosing delayed prescription were similar for parents considering treatment for a child (44% of choices versus 42% for adults, p = 0.04). However, parents differed from the adult sample in showing a more marked reduction in choice of the delayed prescription with increasing duration of illness (OR 0.83 (0.80 to 0.87) versus 0.94 (0.92 to 0.96) for adults, p for heterogeneity p < 0.001) and a smaller effect of disruption of usual activities (OR 0.96 (0.95 to 0.97) versus 0.93 (0.92 to 0.94) for adults, p for heterogeneity p < 0.001). Females were more likely to choose a delayed prescription than males for minor symptoms, particularly minor cough (probability 0.62 (0.58 to 0.66, p < 0.001) for females and 0.45 (0.41 to 0.48, p < 0.001) for males). Older people, those with a good understanding of antibiotics, and those who had not used antibiotics recently showed similar patterns of preferences. Study limitations include its hypothetical nature, which may not reflect real-life behaviour; the absence of a "no prescription" option; and the possibility that study respondents may not represent the views of population groups who are typically underrepresented in online surveys.ConclusionsThis study found that delayed prescription appears to be an acceptable approach to reducing antibiotic consumption. Certain groups appear to be more amenable to delayed prescription, suggesting particular opportunities for increased use of this strategy. Prescribing choices for sore throat may need additional explanation to ensure patient acceptance, and parents in particular may benefit from reassurance about the usual duration of these illnesses.
Published: 2021
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9. Availability and funding of clinical genomic sequencing globally

Author: Sarah Wordsworth, Kathryn A Phillips, Michael P Douglas, and James Buchanan
Subjects: Medicine (General), R5-920, Infectious and parasitic diseases, RC109-216
Abstract: The emergence of next-generation genomic sequencing (NGS) tests for use in clinical care has generated widespread interest around the globe, but little is known about the availability and funding of these tests worldwide. We examined NGS availability across world regions and countries, with a particular focus on availability of three key NGS tests—Whole-Exome Sequencing or Whole-Genome Sequencing for diagnosis of suspected genetic diseases such as intellectual disability disorders or rare diseases, non-invasive prenatal testing for common genetic abnormalities in fetuses and tumor sequencing for therapy selection and monitoring of cancer treatment. We found that these NGS tests are available or becoming available in every major region of the world. This includes both high-income countries with robust genomic programmes such as the USA and the UK, and growing availability in countries with upper-middle-income economies. We used exploratory case studies across three diverse health care systems (publicly funded/national (UK), publicly funded/provincial (Canada) and mixed private/public system (USA)) to illustrate the funding challenges and approaches used to address those challenges that might be adopted by other countries. We conclude by assessing what type of data and initiatives will be needed to better track and understand the use of NGS around the world as such testing continues to expand.
Published: 2021
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10. Rettegés a szabadságtól

Author: James Buchanan and VITA GOLODJUK
Subjects: Economic theory. Demography, HB1-3840, Economic history and conditions, HC10-1085
Abstract: James Buchanan, a Nobel-díjas amerikai közgazdász gondolatai a piacgazdaság etikus alapjairól, Németország problémáiról és a vallási fanatizmus veszélyeiről.
Published: 2020

11. Erratum to: Methods for evaluating medical tests and biomarkers

Author: Gowri Gopalakrishna, Miranda Langendam, Rob Scholten, Patrick Bossuyt, Mariska Leeflang, Anna Noel-Storr, James Thomas, Iain Marshall, Byron Wallace, Penny Whiting, Clare Davenport, Gowri GopalaKrishna, Isabel de Salis, Sue Mallett, Robert Wolff, Richard Riley, Marie Westwood, Jos Kleinen, Gary Collins, Hans Reitsma, Karel Moons, Antonia Zapf, Annika Hoyer, Katharina Kramer, Oliver Kuss, J. Ensor, J. J. Deeks, E. C. Martin, R. D. Riley, Gerta Rücker, Susanne Steinhauser, Martin Schumacher, Joie Ensor, Kym Snell, Brian Willis, Thomas Debray, Jon Deeks, Lavinia Ferrante di Ruffano, Sian Taylor-Phillips, Chris Hyde, Stuart A. Taylor, Gauraang Batnagar, STREAMLINE COLON Investigators, STREAMLINE LUNG Investigators, METRIC Investigators, Lavinia Ferrante Di Ruffano, Farah Seedat, Aileen Clarke, Sarah Byron, Frances Nixon, Rebecca Albrow, Thomas Walker, Carla Deakin, Zhivko Zhelev, Harriet Hunt, Yaling Yang, Lucy Abel, James Buchanan, Thomas Fanshawe, Bethany Shinkins, Laure Wynants, Jan Verbakel, Sabine Van Huffel, Dirk Timmerman, Ben Van Calster, Aeliko Zwinderman, Jason Oke, Jack O’Sullivan, Rafael Perera, Brian Nicholson, Hannah L. Bromley, Tracy E. Roberts, Adele Francis, Denniis Petrie, G. Bruce Mann, Kinga Malottki, Holly Smith, Lucinda Billingham, Alice Sitch, Oke Gerke, Mie Holm-Vilstrup, Eivind Antonsen Segtnan, Ulrich Halekoh, Poul Flemming Høilund-Carlsen, Bernard G. Francq, Jac Dinnes, Julie Parkes, Walter Gregory, Jenny Hewison, Doug Altman, William Rosenberg, Peter Selby, Julien Asselineau, Paul Perez, Aïssatou Paye, Emilie Bessede, Cécile Proust-Lima, Christiana Naaktgeboren, Joris de Groot, Anne Rutjes, Johannes Reitsma, Emmanuel Ogundimu, Jonathan Cook, Yannick Le Manach, Yvonne Vergouwe, Romin Pajouheshnia, Rolf Groenwold, Karen Moons, Linda Peelen, Daan Nieboer, Bavo De Cock, Micael J. Pencina, Ewout W. Steyerberg, Jennifer Cooper, Nick Parsons, Chris Stinton, Steve Smith, Andy Dickens, Rachel Jordan, Alexandra Enocson, David Fitzmaurice, Peymane Adab, Charles Boachie, Gaj Vidmar, Karoline Freeman, Martin Connock, Rachel Court, Carl Moons, Jessica Harris, Andrew Mumford, Zoe Plummer, Kurtis Lee, Barnaby Reeves, Chris Rogers, Veerle Verheyden, Gianni D. Angelini, Gavin J. Murphy, Jeremy Huddy, Melody Ni, Katherine Good, Graham Cooke, George Hanna, Jie Ma, K. G. M. (Carl) Moons, Joris A. H. de Groot, Doug G. Altman, Johannes B. Reitsma, Gary S. Collins, Karel G. M. Moons, Douglas G. Altman, Adina Najwa Kamarudin, Ruwanthi Kolamunnage-Dona, Trevor Cox, Simone Borsci, Teresa Pérez, M.Carmen Pardo, Angel Candela-Toha, Alfonso Muriel, Javier Zamora, Sabina Sanghera, Syed Mohiuddin, Richard Martin, Jenny Donovan, Joanna Coast, Mikyung Kelly Seo, John Cairns, Elizabeth Mitchell, Alison Smith, Judy Wright, Peter Hall, Michael Messenger, Nicola Calder, Nyantara Wickramasekera, Karen Vinall-Collier, Andrew Lewington, Johanna Damen, David Cairns, Michelle Hutchinson, Cathie Sturgeon, Liz Mitchel, Rebecca Kift, Sofia Christakoudi, Manohursingh Rungall, Paula Mobillo, Rosa Montero, Tjir-Li Tsui, Sui Phin Kon, Beatriz Tucker, Steven Sacks, Chris Farmer, Terry Strom, Paramit Chowdhury, Irene Rebollo-Mesa, Maria Hernandez-Fuentes, Johanna A. A. G. Damen, Thomas P. A. Debray, Pauline Heus, Lotty Hooft, Rob J. P. M. Scholten, Ewoud Schuit, Ioanna Tzoulaki, Camille M. Lassale, George C. M. Siontis, Virginia Chiocchia, Corran Roberts, Michael Maia Schlüssel, Stephen Gerry, James A. Black, Yvonne T. van der Schouw, Linda M. Peelen, Graeme Spence, David McCartney, Ann van den Bruel, Daniel Lasserson, Gail Hayward, Werner Vach, Antoinette de Jong, Coreline Burggraaff, Otto Hoekstra, Josée Zijlstra, Henrica de Vet, Sara Graziadio, Joy Allen, Louise Johnston, Rachel O’Leary, Michael Power, Louise Johnson, Ray Waters, John Simpson, Thomas R. Fanshawe, Peter Phillips, Andrew Plumb, Emma Helbren, Steve Halligan, Alastair Gale, Peggy Sekula, Willi Sauerbrei, Julia R. Forman, Susan J. Dutton, Yemisi Takwoingi, Elizabeth M. Hensor, Thomas E. Nichols, Emmanuelle Kempf, Raphael Porcher, Jennifer de Beyer, Douglas Altman, Sally Hopewell, John Dennis, Beverley Shields, Angus Jones, William Henley, Ewan Pearson, Andrew Hattersley, on behalf of the MASTERMIND consortium, Fueloep Scheibler, Anne Rummer, Sibylle Sturtz, Robert Großelfinger, Katie Banister, Craig Ramsay, Augusto Azuara-Blanco, Jennifer Burr, Manjula Kumarasamy, Rupert Bourne, Ijeoma Uchegbu, Jennifer Murphy, Alex Carter, Jen Murphy, Joachim Marti, Julie Eatock, Julie Robotham, Maria Dudareva, Mark Gilchrist, Alison Holmes, Phillip Monaghan, Sarah Lord, Andrew StJohn, Sverre Sandberg, Christa Cobbaert, Lieselotte Lennartz, Wilma Verhagen-Kamerbeek, Christoph Ebert, Andrea Horvath, for the Test Evaluation Working Group of the European Federation of Clinical Chemistry and Laboratory Medicine, Kevin Jenniskens, Jaime Peters, Bogdan Grigore, Obi Ukoumunne, Brooke Levis, Andrea Benedetti, Alexander W. Levis, John P. A. Ioannidis, Ian Shrier, Pim Cuijpers, Simon Gilbody, Lorie A. Kloda, Dean McMillan, Scott B Patten, Russell J. Steele, Roy C Ziegelstein, Charles H. Bombardier, Flavia de Lima Osório, Jesse R. Fann, Dwenda Gjerdingen, Femke Lamers, Manote Lotrakul, Sonia R Loureiro, Bernd Löwe, Juwita Shaaban, Lesley Stafford, Henk C. P. M. van Weert, Mary A. Whooley, Linda S. Williams, Karin A. Wittkampf, Albert S. Yeung, Brett D. Thombs, Chris Cooper, Tom Nieto, Claire Smith, Olga Tucker, Janine Dretzke, Andrew Beggs, Nirmala Rai, Sue Bayliss, Simon Stevens, Sue Mallet, Sudha Sundar, Emma Hall, Nuria Porta, David Lorente Estelles, Johann de Bono, and on behalf of the CTC-STOP protocol development group
Subjects: Medicine (General), R5-920
Published: 2017
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12. Awareness of Appropriate Antibiotic Use in Primary Care for Influenza-Like Illness: Evidence of Improvement from UK Population-Based Surveys

Author: Koen B. Pouwels, Laurence S. J. Roope, James Buchanan, Liz Morrell, Sarah Tonkin-Crine, Michele Peters, Leah F. Jones, Enrique Castro-Sánchez, Derrick W. Crook, Tim Peto, Christopher C. Butler, Julie V. Robotham, A. Sarah Walker, and Sarah Wordsworth
Subjects: antibiotics, antimicrobial resistance, survey, Therapeutics. Pharmacology, RM1-950
Abstract: Influenza-like illnesses (ILI) account for a significant portion of inappropriate antibiotic use. Patient expectations for antibiotics for ILI are likely to play a substantial role in ‘unnecessary’ antibiotic consumption. This study aimed to investigate trends in awareness of appropriate antibiotic use and antimicrobial resistance (AMR). Three sequential online surveys of independent representative samples of adults in the United Kingdom investigated expectations for, and consumption of, antibiotics for ILI (May/June 2015 (n = 2064); Oct/Nov 2016 (n = 4000); Mar 2017 (n = 4000)). Respondents were asked whether they thought antibiotics were effective for ILI and about their antibiotic use. Proportions and 95% confidence intervals (CI) were calculated for each question and interactions with respondent characteristics were tested using logistic regression. Over the three surveys, the proportion of respondents who believed antibiotics would “definitely/probably” help an ILI fell from 37% (95% CI 35–39%) to 28% (95% CI 26–29%). Those who would “definitely/probably” visit a doctor in this situation fell from 48% (95% CI 46–50%) to 36% (95% CI 34–37%), while those who would request antibiotics during a consultation fell from 39% (95% CI 37–41%) to 30% (95% CI 29–32%). The percentage of respondents who found the information we provided about AMR “new/surprising” fell from 34% (95% CI 32–36%) to 28% (95% CI 26–31%). Awareness improved more among black, Asian and minority ethnic (BAME) than white people, with little other evidence of differences in improvements between subgroups. Whilst a degree of selection bias is unavoidable in online survey samples, the results suggest that awareness of AMR and appropriate antibiotic use has recently significantly improved in the United Kingdom, according to a wide range of indicators.
Published: 2020
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13. Delayed Antibiotic Prescription by General Practitioners in the UK: A Stated-Choice Study

Author: Liz Morrell, James Buchanan, Laurence S. J. Roope, Koen B. Pouwels, Christopher C. Butler, Benedict Hayhoe, Michael V. Moore, Sarah Tonkin-Crine, Monsey McLeod, Julie V. Robotham, A. Sarah Walker, Sarah Wordsworth, and on behalf of the STEPUP team
Subjects: antibiotic resistance, choice experiment, primary care, general practice, delayed prescription, respiratory tract infection, Therapeutics. Pharmacology, RM1-950
Abstract: Delayed antibiotic prescription in primary care has been shown to reduce antibiotic consumption, without increasing risk of complications, yet is not widely used in the UK. We sought to quantify the relative importance of factors affecting the decision to give a delayed prescription, using a stated-choice survey among UK general practitioners. Respondents were asked whether they would provide a delayed or immediate prescription in fifteen hypothetical consultations, described by eight attributes. They were also asked if they would prefer not to prescribe antibiotics. The most important determinants of choice between immediate and delayed prescription were symptoms, duration of illness, and the presence of multiple comorbidities. Respondents were more likely to choose a delayed prescription if the patient preferred not to have antibiotics, but consultation length had little effect. When given the option, respondents chose not to prescribe antibiotics in 51% of cases, with delayed prescription chosen in 21%. Clinical features remained important. Patient preference did not affect the decision to give no antibiotics. We suggest that broader dissemination of the clinical evidence supporting use of delayed prescription for specific presentations may help increase appropriate use. Establishing patient preferences regarding antibiotics may help to overcome concerns about patient acceptance. Increasing consultation length appears unlikely to affect the use of delayed prescription.
Published: 2020
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14. Translating Thailand's Protests: An Analysis of Red Shirt Rhetoric

Author: James Buchanan
Subjects: Protest, Red Shirts, Social Movement, Thailand, Thai Political Crisis, Political science, Social Sciences
Published: 2013
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15. Can rapid integrated polymerase chain reaction-based diagnostics for gastrointestinal pathogens improve routine hospital infection control practice? A diagnostic study

Author: Louise Pankhurst, Louissa Macfarlane-Smith, James Buchanan, Luke Anson, Kerrie Davies, Lily O’Connor, Helen Ashwin, Graham Pike, Kate E Dingle, Timothy EA Peto, Sarah Wordsworth, A Sarah Walker, Mark H Wilcox, and Derrick W Crook
Subjects: diagnostic study, infection control, infectious diarrhoea, masscode, luminex, enterobacteriaceae, Medical technology, R855-855.5
Abstract: Background: Every year approximately 5000–9000 patients are admitted to a hospital with diarrhoea, which in up to 90% of cases has a non-infectious cause. As a result, single rooms are ‘blocked’ by patients with non-infectious diarrhoea, while patients with infectious diarrhoea are still in open bays because of a lack of free side rooms. A rapid test for differentiating infectious from non-infectious diarrhoea could be very beneficial for patients. Objective: To evaluate MassCode multiplex polymerase chain reaction (PCR) for the simultaneous diagnosis of multiple enteropathogens directly from stool, in terms of sensitivity/specificity to detect four common important enteropathogens: Clostridium difficile, Campylobacter spp., Salmonella spp. and norovirus. Design: A retrospective study of fixed numbers of samples positive for C. difficile (n = 200), Campylobacter spp. (n = 200), Salmonella spp. (n = 100) and norovirus (n = 200) plus samples negative for all these pathogens (n = 300). Samples were sourced from NHS microbiology laboratories in Oxford and Leeds where initial diagnostic testing was performed according to Public Health England methodology. Researchers carrying out MassCode assays were blind to this information. A questionnaire survey, examining current practice for infection control teams and microbiology laboratories managing infectious diarrhoea, was also carried out. Setting: MassCode assays were carried out at Oxford University Hospitals NHS Trust. Further multiplex assays, carried out using Luminex, were run on the same set of samples at Leeds Teaching Hospitals NHS Trust. The questionnaire was completed by various NHS trusts. Main outcome measures: Sensitivity and specificity to detect C. difficile, Campylobacter spp., Salmonella spp., and norovirus. Results: Nucleic acids were extracted from 948 clinical samples using an optimised protocol (200 Campylobacter spp., 199 C. difficile, 60 S. enterica, 199 norovirus and 295 negative samples; some samples contained more than one pathogen). Using the MassCode assay, sensitivities for each organism compared with standard microbiological testing ranged from 43% to 94% and specificities from 95% to 98%, with particularly poor performance for S. enterica. Relatively large numbers of unexpected positives not confirmed with quantitative PCR were also observed, particularly for S. enterica, Giardia lamblia and Cryptosporidium spp. As the results indicated that S. enterica detection might provide generic challenges to other multiplex assays for gastrointestinal pathogens, the Luminex xTag® gastrointestinal assay was also run blinded on the same extracts (937/948 remaining) and on re-extracted samples (839/948 with sufficient material). For Campylobacter spp., C. difficile and norovirus, high sensitivities (> 92%) and specificities (> 96%) were observed. For S. enterica, on the original MassCode/Oxford extracts, Luminex sensitivity compared with standard microbiological testing was 84% [95% confidence interval (CI) 73% to 93%], but this dropped to 46% on a fresh extract, very similar to MassCode, with a corresponding increase in specificity from 92% to 99%. Overall agreement on the per-sample diagnosis compared with combined microbiology plus PCR for the main four/all pathogens was 85.6%/64.7%, 87.0%/82.9% and 89.8%/86.8% for the MassCode assay, Luminex assay/MassCode extract and Luminex assay/fresh extract, respectively. Luminex assay results from fresh extracts implied that 5% of samples did not represent infectious diarrhoea, even though enteropathogens were genuinely present. Managing infectious diarrhoea was a significant burden for infection control teams (taking 21% of their time) and better diagnostics were identified as having major potential benefits for patients. Conclusions: Overall, the Luminex xTag gastrointestinal panel showed similar or superior sensitivity and specificity to the MassCode assay. However, on fresh extracts, this test had low sensitivity to detect a key enteric pathogen, S. enterica; making it an unrealistic option for most microbiology laboratories. Extraction efficiency appears to be a major obstacle for nucleic acid-based tests for this organism, and possibly the whole Enterobacteriaceae family. To improve workflows in service microbiology laboratories, to reduce workload for infection control practitioners, and to improve outcomes for NHS patients, further research on deoxyribonucleic acid-based multiplex gastrointestinal diagnostics is urgently needed. Funding: The Health Technology Assessment programme of the National Institute for Health Research.
Published: 2014
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16. Cost-effectiveness of pre-referral antimalarial, antibacterial, and combined rectal formulations for severe febrile illness.

Author: James Buchanan, Borislava Mihaylova, Alastair Gray, and Nicholas White
Subjects: Medicine, Science
Abstract: Malaria and bacterial infections account for most infectious disease deaths in developing countries. Prompt treatment saves lives, but rapid deterioration often prevents the use of oral therapies; delays in reaching health facilities providing parenteral interventions are common. Rapidly and reliably absorbed antimalarial/antibacterial rectal formulations used in the community could prevent deaths and disabilities. Rectal antimalarial treatments are currently available; rectal antibacterial treatments are yet to be developed. Assessment of the likely cost-effectiveness of these interventions will inform research priorities and implementation.The burden of malaria and bacterial infections worldwide and in Sub-Saharan and Southern Africa (SSA) and South and South-East Asia (SEA) was summarised using published data. The additional healthcare costs (US$) per death and per Disability Adjusted Life Year (DALY) avoided following pre-referral treatment of severe febrile illness with rectal antimalarials, antibacterials or combined antimalarial/antibacterials in populations at malaria risk in SSA/SEA were assessed. 46 million severe malaria and bacterial infections and 5 million deaths occur worldwide each year, mostly in SSA/SEA. At annual delivery costs of $0.02/capita and 100% coverage, rectal antimalarials ($2 per dose) would avert 240,000 deaths in SSA and 7,000 deaths in SEA at $5 and $177 per DALY avoided, respectively; rectal antibacterials ($2 per dose) would avert 130,000 deaths in SSA and 27,000 deaths in SEA at $19 and $97 per DALY avoided, respectively. Combined rectal formulations ($2.50 per dose) would avert 370,000 deaths in SSA and 33,000 deaths in SEA at $8 and $79 per DALY avoided, respectively, and are a cost-effective alternative to rectal antimalarials or antibacterials alone.Antimalarial, antibacterial and combined rectal formulations are likely to be cost-effective interventions for severe febrile illness in the community. Attention should focus on developing effective rectal antibacterials and ensuring that these lifesaving treatments are used in a cost-effective manner.
Published: 2010
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17. Modern Orthodox Biblical Interpretation

Author: Wallace, James Buchanan, primary
Published: 2022
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18. GParareal: A time-parallel ODE solver using Gaussian process emulation.

Author: Kamran Pentland, Massimiliano Tamborrino, Timothy John Sullivan, James Buchanan, and Lynton C. Appel
Published: 2022

19. GParareal: a time-parallel ODE solver using Gaussian process emulation.

Author: Kamran Pentland, Massimiliano Tamborrino, Timothy John Sullivan, James Buchanan, and Lynton C. Appel
Published: 2023
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20. The knowledge economy: Key to sustainable development?

Author: Rezny, Lukas, White, James Buchanan, and Maresova, Petra
Published: 2019
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21. Performance of the BGSDC integrator for computing fast ion trajectories in nuclear fusion reactors.

Author: Krasymyr Tretiak, James Buchanan, Rob J. Akers, and Daniel Ruprecht
Published: 2020

22. Classification and management of USDI Bureau of Land Management's riparian and wetland sites in eastern and southern Idaho

Author: Hansen, Paul L., Hall, James Buchanan, Rice, Karen, United States. Bureau of Land Management. Upper Snake River District, United States. Bureau of Land Management. Idaho State Office, Bitterroot Restoration, Inc, Bureau of Land Management (archive.org), Hansen, Paul L., Hall, James Buchanan, Rice, Karen, United States. Bureau of Land Management. Upper Snake River District, United States. Bureau of Land Management. Idaho State Office, and Bitterroot Restoration, Inc
Subjects: Bureau of Land Management, Classification, Idaho, Management, Riparian areas, Riparian ecology, United States, Upper Snake River District, Wetland ecology, Wetland management, Wetlands
Published: 2002

23. Assessing adverse events in clinical trials during the era of the COVID-19 pandemic

Author: James Buchanan, Mengchun Li, Barbara Hendrickson, Parul Bhargava, and Satrajit Roychoudhury
Subjects: Pharmacology, Statistics and Probability, Pharmacology (medical)
Published: 2023

24. Colony size effect on neural differentiation of embryonic stem cells microprinted on stromal cells.

Author: Ramila Joshi, James Buchanan, and Hossein Tavana
Published: 2016
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25. Management of Slipped Gastric Bands via Creation of a De Novo Tunnel and Band Replacement: a Single-Centre Experience

Author: Patel, Roshani Vijaykumar, Woodburn, Patrick, Skipworth, James R. A., and Smellie, William James Buchanan
Published: 2018
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26. Performance of the BGSDC integrator for computing fast ion trajectories in nuclear fusion reactors.

Author: Krasymyr Tretiak, James Buchanan, Rob J. Akers, and Daniel Ruprecht
Published: 2021
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27. Important Considerations for Signal Detection and Evaluation

Author: James Buchanan and Mengchun Li
Subjects: Public Health, Environmental and Occupational Health, Pharmacology (medical), Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract: Safety clinicians have a wealth of resources describing how to perform signal detection. Nevertheless, there are some nuances concerning approaches taken by regulatory authorities and statistical considerations that should be appreciated. New approaches, such as the FDA Medical Queries, illustrate the value of considering medical concepts over individual adverse events. One area which would benefit from further clarity is how safety signals may be evaluated for evidence of a causal relationship to the drug of interest. Just as such safety signals can take many forms, the types of tools and methods required to interrogate these signals are equally as diverse. An understanding of the complexity of this process can aid the safety reviewer in successfully characterizing the emerging safety profile of a drug during the pre-marketing phase of development.
Published: 2023

28. Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models

Author: Weiqi Liao, Carol A C Coupland, Judith Burchardt, David R Baldwin, Fergus V Gleeson, Julia Hippisley-Cox, Fergus Gleeson, David Baldwin, George Batchkala, James Buchanan, Rohan Chakraborty, Ravi Chana, Yan Chen, Carol Coupland, Charles Crichton, Jim Davies, Anand Devaraj, Mengran Fan, Rositsa Koleva-Kolarova, Richard Lee, Arjun Nair, Lyndsey Pickup, Anne Powell, Jens Rittscher, Amied Shadmaan, Kandavel Shanmugam, Elizabeth Stokes, Clare Verrill, Johnathan Watkins, and Sarah Wordsworth
Subjects: Pulmonary and Respiratory Medicine
Published: 2023

29. The Rustle of Paul: Autobiographical Narratives in Romans, Corinthians, and Philippians. By <scp>Scott Elliott</scp>

Author: James Buchanan Wallace
Subjects: Religious studies
Published: 2022

30. Eliciting risk preferences that predict risky health behavior: A comparison of two approaches

Author: Murong Yang, Laurence S. J. Roope, James Buchanan, Arthur E. Attema, Philip M. Clarke, A. Sarah Walker, Sarah Wordsworth, and Health Economics (HE)
Subjects: Adult, Health Risk Behaviors, SDG 3 - Good Health and Well-being, Health Policy, Health Behavior, Humans
Abstract: Information on attitudes to risk could increase understanding of and explain risky health behaviors. We investigate two approaches to eliciting risk preferences in the health domain, a novel “indirect” lottery elicitation approach with health states as outcomes and a “direct” approach where respondents are asked directly about their willingness to take risks. We compare the ability of the two approaches to predict health-related risky behaviors in a general adult population. We also investigate a potential framing effect in the indirect lottery elicitation approach. We find that risk preferences elicited using the direct approach can better predict health-related risky behavior than those elicited using the indirect approach. Moreover, a seemingly innocuous change to the framing of the lottery question results in significantly different risk preference estimates, and conflicting conclusions about the ability of the indicators to predict risky health behaviors.
Published: 2022

31. HALO: A full-orbit model of nonlinear interaction of fast particles with eigenmodes.

Author: M. Fitzgerald, James Buchanan, Rob J. Akers, Boris N. Breizman, and S. E. Sharapov
Published: 2020
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32. Immersive Virtual Reality for the Cognitive Rehabilitation of Stroke Survivors

Author: Sara Hughes, Kausik Chatterjee, Alastair James Buchanan, Katy Cottrell, Nigel John, and Thomas Day
Subjects: Stroke, Cognition, Virtual Reality Exposure Therapy, General Neuroscience, Activities of Daily Living, Rehabilitation, Stroke Rehabilitation, Virtual Reality, Biomedical Engineering, Internal Medicine, Humans, Survivors
Abstract: We present the results of a double-blind phase 2b randomized control trial that used a custom built virtual reality environment for the cognitive rehabilitation of stroke survivors. A stroke causes damage to the brain and problem solving, memory and task sequencing are commonly affected. The brain can recover to some extent, however, and stroke patients have to relearn how to carry out activities of daily living. We have created an application called VIRTUE to enable such activities to be practiced using immersive virtual reality. Gamification techniques enhance the motivation of patients such as by making the level of difficulty of a task increase over time. The design and implementation of VIRTUE is described together with the results of the trial conducted within the Stroke Unit of a large hospital. We report on the safety and acceptability of VIRTUE. We have also observed particular benefits of VR treatment for stroke survivors that experienced more severe cognitive impairment, and an encouraging reduction in time spent in the hospital for all patients that received the VR treatment.
Published: 2022

33. Contributors

Author: James Buchanan, Usa Chaikledkaew, Ian Cromwell, Brett Doble, Morgan Ehman, Patrick Fahr, Vasileios Fragoulakis, Jiraphun Jittikoon, Maria Koromina, Margarita-Ioanna Koufaki, Paula K. Lorgelly, Surakameth Mahasirimongkol, Deborah Marshall, Christopher McCabe, Christina Mitropoulou, George P. Patrinos, Katherine Payne, Kathryn Philips, Samantha Pollard, Kinasih Prayuni, Dean A. Regier, Saowalak Turongkaravee, Athanassios Vozikis, Sukanya Wattanapokayakit, Deirdre Weymann, Sarah Wordsworth, Rika Yuliwulandari, and Hilyatuz Zahroh
Published: 2023

34. Introduction to economic evaluation in health sciences

Author: Christina Mitropoulou, Vasileios Fragoulakis, James Buchanan, Sarah Wordsworth, and George P. Patrinos
Published: 2023

35. Preface

Author: Christina Mitropoulou, Sarah Wordsworth, James Buchanan, and George P. Patrinos
Published: 2023

36. Using 'big data' for economic evaluations in genomics

Author: Sarah Wordsworth, Brett Doble, Katherine Payne, James Buchanan, Deborah Marshall, Christopher McCabe, Kathryn Philips, Patrick Fahr, and Dean A. Regier
Published: 2023

37. 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report

Author: Gill Wilson, Anna de Burca, Marta Bleda, Lucy R. Wedderburn, Matthew Welland, Kathleen Stirrups, Valentina Cipriani, Kerrie Woods, Vijeya Ganesan, Susan Hill, Rosaline Quinlivan, Georgia Chan, Mehul T. Dattani, Robert McFarland, Graeme C.M. Black, Rutendo Mapeta, Augusto Rendon, Francesco Muntoni, James O.J. Davies, Mina Ryten, Rebecca E. Foulger, Arianna Tucci, Dina Halai, Tom Fowler, Noemi B.A. Roy, Sarah Leigh, Dragana Josifova, Philip Twiss, Ana L.T. Tavares, Zerin Hyder, Detlef Bockenhauer, Patrick Yu-Wai-Man, Lara Abulhoul, Nikolas Pontikos, Anthony T. Moore, Huw R. Morris, Patrick F. Chinnery, Nicholas W. Wood, Ellen A. Thomas, Shehla Mohammed, Sofia Douzgou, Tanya Lam, Kate Gibson, Robert Sarkany, Teofila Bueser, Wei Wei, Siddharth Banka, Alexander Broomfield, Hiva Fassihi, Nils Koelling, Carolyn Campbell, James Buchanan, Melita Irving, Sandrine Compeyrot-Lacassagne, Karola Rehmström, Austen Worth, Nikhil Thapar, Andrew R. Webster, Paul Brennan, Rita Horvath, Gavin Arno, Richard H Scott, Sam Malka, Andrew O.M. Wilkie, Sofie Ashford, Maria Bitner-Glindzicz, Jana Vandrovcova, William G. Newman, Caroline F. Wright, Andrew M. Schaefer, Roger F.L. James, Robert W. Taylor, Melanie Babcock, Arjune Sen, Emma Baple, Ellen M. McDonagh, Stephanie Grunewald, Loukas Moutsianas, Melissa A. Haendel, Olivera Spasic-Boskovic, Eleanor G. Seaby, Anna Need, Clarissa Pilkington, Sarah Wordsworth, Shamima Rahman, Christine Patch, Colin Wallis, Kristina Ibanez, Bishoy Habib, Eik Haraldsdottir, Huw B. Thomas, Razvan Sultana, Andrea H. Németh, Agata Wolejko, Claire Palles, Phil Beales, Adam C. Shaw, Letizia Vestito, Emily Li, Sarah Rose, Sarah Hunter, Angela Matchan, Genevieve Say, Dalia Kasperaviciute, Henry Houlden, Raymond T. O’Keefe, R. Andres Floto, Jill Clayton-Smith, John B. Taylor, Hywel J. Williams, Volker Straub, Val Davison, Helen Savage, John Chisholm, Eleanor Dewhurst, Charles Crichton, Andrea Haworth, Clare Turnbull, Carolyn Tregidgo, Carme Camps, Christopher Penkett, Emer O’Connor, Georgina Hall, Lyn S. Chitty, Sally Halsall, Andrew D. Mumford, Annette G. Wagner, Eleanor Williams, Mark Bale, Julius O. Jacobsen, Willem H. Ouwehand, Charu Deshpande, Gavin Burns, Smita Y. Patel, James Polke, Thiloka Ratnaike, Gavin Fuller, John Burn, Kenneth E. S. Poole, Emma Footitt, John R. Bradley, Suzanne Wood, Russell J. Grocock, Jenny C. Taylor, Louise Izatt, Kikkeri N. Naresh, Katherine R. Smith, Nigel Burrows, Katrina Newland, Peter N. Robinson, Sarju G. Mehta, Michael A. Simpson, Michael R. Barnes, Pilar Cacheiro, Olivia Niblock, Tracy Lester, Dimitris Polychronopoulos, Helen Brittain, John A. Sayer, Antonio Martin, Eshika Haque, Sean Humphray, Douglass M. Turnbull, Damian Smedley, Andrew Devereau, Stefan Gräf, Sian Ellard, Ivone U.S. Leong, Martin G. Reese, Matthias Wielscher, Louise C. Daugherty, Perry M. Elliott, F. Lucy Raymond, Cecilia Compton, David Bentley, Catherine Snow, James Welch, Frances Flinter, Dom McMullan, Mark J. Caulfield, Paul Aurora, Mark Gurnell, Mary Kasanicki, I. Karen Temple, Michel Michaelides, Deborah Ruddy, Leema Robert, Janice Yip, Grainne S. Gorman, Andrew C. Browning, Richard Quinton, Maureen Cleary, Jamie M. Ellingford, Angela Douglas, Christopher Boustred, and Investigators, The 100,000 Genomes Project Pilot
Subjects: Adult, Male, Proband, medicine.medical_specialty, Adolescent, Pilot Projects, Genomics, Polymerase Chain Reaction, Genome, State Medicine, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Health care, Human Phenotype Ontology, Humans, Medicine, Child, Exome sequencing, 030304 developmental biology, Family Characteristics, 0303 health sciences, Whole Genome Sequencing, Genome, Human, business.industry, Genetic Variation, Rare Diseases/diagnosis, General Medicine, Middle Aged, United Kingdom, 3. Good health, Child, Preschool, Family medicine, Medical genetics, Female, business, Bristol, 030217 neurology & neurosurgery, Rare disease
Abstract: BACKGROUND: The U.K. 100,000 Genomes Project is in the process of investigating the role of genome sequencing in patients with undiagnosed rare diseases after usual care and the alignment of this research with health care implementation in the U.K. National Health Service. Other parts of this project focus on patients with cancer and infection.METHODS: We conducted a pilot study involving 4660 participants from 2183 families, among whom 161 disorders covering a broad spectrum of rare diseases were present. We collected data on clinical features with the use of Human Phenotype Ontology terms, undertook genome sequencing, applied automated variant prioritization on the basis of applied virtual gene panels and phenotypes, and identified novel pathogenic variants through research analysis.RESULTS: Diagnostic yields varied among family structures and were highest in family trios (both parents and a proband) and families with larger pedigrees. Diagnostic yields were much higher for disorders likely to have a monogenic cause (35%) than for disorders likely to have a complex cause (11%). Diagnostic yields for intellectual disability, hearing disorders, and vision disorders ranged from 40 to 55%. We made genetic diagnoses in 25% of the probands. A total of 14% of the diagnoses were made by means of the combination of research and automated approaches, which was critical for cases in which we found etiologic noncoding, structural, and mitochondrial genome variants and coding variants poorly covered by exome sequencing. Cohortwide burden testing across 57,000 genomes enabled the discovery of three new disease genes and 19 new associations. Of the genetic diagnoses that we made, 25% had immediate ramifications for clinical decision making for the patients or their relatives.CONCLUSIONS: Our pilot study of genome sequencing in a national health care system showed an increase in diagnostic yield across a range of rare diseases. (Funded by the National Institute for Health Research and others.).
Published: 2021

38. Histological findings of tracheal samples from COVID‐19 positive critically ill mechanically ventilated patients

Author: Patrick Alexander, Ward, Jonathan Marc, Collier, Justin, Weir, Michael, Osborn, Brian, Hanley, William James Buchanan, Smellie, and Andrew, Williams
Subjects: Male, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, Pneumonia, Viral, Autopsy, histology, Tracheostomy, Tracheitis, COVID‐19, London, Humans, Medicine, Stage (cooking), Retrospective Studies, Mechanical ventilation, SARS-CoV-2, business.industry, mechanically ventilated, COVID-19, Histology, Original Articles, Middle Aged, medicine.disease, Respiration, Artificial, ulceration, Trachea, Intensive Care Units, Cross-Sectional Studies, Otorhinolaryngology, inflammation, Anesthesia, Mild Chronic Inflammation, tracheal, Female, Original Article, business, Cohort study
Abstract: Objectives This study examines the histological findings of tracheal tissue samples obtained from COVID‐19 positive mechanically ventilated patients, to assess the degree of tracheal inflammation/ulceration present. Design and participants Retrospective single‐centre observational cohort study. All patients admitted to Adult Intensive Care Unit (AICU) with COVID‐19 infection, requiring mechanical ventilation and surgical tracheostomy between 1 April and 1 May 2020, were included (Group 1). Tracheal windows excised at tracheostomy underwent histological analysis. Comparison was made with: tracheal windows from COVID‐19 positive AICU ventilated patients admitted between 1 January and 1 March 2021 (Group 2); tracheal windows from COVID‐19 negative AICU ventilated patients (Group 3); and, tracheal autopsy samples from COVID‐19 positive patients that died without undergoing prolonged mechanical ventilation (Group 4). Results G roup 1 demonstrated mild/moderate inflammation (tracheitis) in nearly all samples (15/16, 93.8%), with infrequent micro‐ulceration (2/16, 12.5%). G roup 2 demonstrated similar mild/moderate inflammation in all samples (17/17, 100%), with no ulceration. Histological findings of Groups 1 and 2 COVID‐19 positive patients were similar to Group 3 COVID‐19 negative patients, which demonstrated mild/moderate inflammation (5/5, 100%), with uncommon superficial erosion (1/5, 20%). Group 4 demonstrated mild chronic inflammation or no significant inflammation, with uncommon micro‐ulceration (1/4, 25%). Conclusions Severe tracheal inflammation was not demonstrated in mechanically ventilated COVID‐19 positive patients at the level of the second/third tracheal rings, at the stage of disease patients underwent tracheostomy. Histological findings were similar between mechanically ventilated COVID‐19 positive and negative patients. Tracheal ulceration may be a feature of early or severe COVID‐19 disease.
Published: 2021

39. Benefactor and Paradigm

Author: Wallace, James Buchanan, primary
Published: 2016
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40. Genetic services in a resource-constrained African setting – diagnostic odysseys, limited testing strategies and the need for exome sequencing

Author: Emma Wiener, James Buchanan, Zane Lombard, and Amanda Krause
Abstract: Background: Exome sequencing is recommended as a first-line investigation for the diagnosis of developmental disorders (DD). It is uncertain if this recommendation can be translated to a low-resource setting, due to a dearth of research into current diagnostic practices in such settings.Results: A file audit performed on 934 patients presenting to a medical genetics clinic in South Africa showed that 83% of patients presented with DD. Patients could be divided into three groups, representing distinct diagnostic pathways. Patient Group A (18%; mean test cost $131) had genetically confirmed aneuploidies. Patient Group B (25%; mean test cost $140) presented with clinically recognizable conditions however only 39% received a genetic diagnostic confirmation. Patient Group C – the largest group (57%; mean test cost $337) – presented with rare, less recognizable conditions and 92% remained undiagnosed after available testing was performed.Conclusions: Patients with DD are the largest group of patients seen in medical genetics clinics in South Africa. Diagnostic testing approaches are limited, so where clinical features are not distinct, the diagnostic yield is low. A significant proportion of these patients would benefit from first-line exome sequencing, from a time, diagnosis and cost perspective, reducing their individual diagnostic odysseys.
Published: 2022

41. Search for Resonances Decaying to Three W Bosons in Proton-Proton Collisions at s=13 TeV

Author: Viacheslav Bunichev, Mikko Voutilainen, Stefaan Tavernier, Jordan Nash, Francisco Garcia, Raghunath Pradhan, Gabriella Pugliese, Alberto Escalante del Valle, Praveen Chandra Tiwari, Mate Csanad, Kadir Saygin, Kenneth Bloom, Pietro Govoni, Maximilian Pérez Prada, Arie Bodek, Riccardo Salvatico, Mikhail Dubinin, Andrea Cardini, Chang-Seong Moon, Ted Kolberg, Guenakh Mitselmakher, Kun Shi, Caglar Zorbilmez, Lorenzo Viliani, Ankush Reddy Kanuganti, Wesley Smith, Mikael Myllymäki, Hesham El Faham, Walaa Elmetenawee, Erhan Gülmez, Giovanni Abbiendi, Fabrizio Palla, Valentina Sola, Matthias Schröder, Cristina Riccardi, Sami Lehti, Abanti Ranadhir Sahasransu, Joseph Reichert, Jussi Viinikainen, Badder Marzocchi, Luke Kreczko, Hugues Lattaud, FLAVIA CETORELLI, Georgios Konstantinos Krintiras, Samet Lezki, Stefano Belforte, Maria Savina, Reza Goldouzian, Márton Bartók, Daniele Fasanella, Erika Garutti, Shalini Thakur, Louis Moureaux, Nadia Pastrone, Danyer Pérez Adán, Muhammad Ahmad, Konstantin Androsov, Toni Sculac, Arun Kumar, Andreas Pfeiffer, Jorge Berenguer Antequera, Giuseppe Della Ricca, Eduard De La Cruz Burelo, Joern Schwandt, Christopher Tully, Luigi Calligaris, Wael HAJ AHMAD (Vael HAJAHMAD), Jennifer Ott, Francisco Javier Cuevas Maestro, Steffen Albrecht, Pablo Matorras-Cuevas, Prabhat Ranjan Pujahari, Alessandra Cappati, Alexander Belyaev, Florian Bury, James Buchanan, Roman Kogler, Andrea Giammanco, Marco Toliman Lucchini, Guenther Dissertori, Francesca Cavallari, José María Hernández Calama, Antonello Pellecchia, Efe Yazgan, Nils Faltermann, Yuri Gershtein, Sinan Sagir, Tomas Lindén, Halil Saka, Luca Cadamuro, Florencia Canelli, Simone Pigazzini, Armando Bermudez Martinez, Dmitri Konstantinov, Ksenia Shchelina, Cesar Augusto Bernardes, Bingran Wang, Qiang Li, Nicolò Trevisani, Tapio Lampén, Md Naimuddin, Barry Blumenfeld, Leonid Levchuk, Claudio Grandi, Giovanni Petrucciani, Dayong Wang, Marco Zanetti, Cristina Botta, Danilo Meuser, Martti Raidal, John Conway, Jaime Leon Holgado, Paolo Giacomelli, Jay R. Dittmann, Yalcin Guler, Agni Bethani, Marcin Konecki, Franco Ligabue, Alexander Grohsjean, Lourdes Urda, Mahmoud Moussa Abdelkhalek Gadallah, Silvano Tosi, Martina Malberti, Merve Ince Lezki, Jochen Schieck, Leonardo Cristella, Ernesto Migliore, Pritam Kalbhor, Silvia Goy Lopez, Ashish Sharma, Tommaso Diotalevi, Nikolaos Manthos, Lisa Benato, Suman Chatterjee, Émilien Chapon, JUAN ALCARAZ MAESTRE, Antonio Vilela Pereira, Álvaro Navarro-Tobar, Thong Q. Nguyen, Zhenbin Wu, Maria Clemencia Mora Herrera, Zhengyun You, Agostino De Iorio, Ilaria Vai, Gilvan Alves, Sandeep Bhowmik, Cristina Fernández Bedoya, Nabin Poudyal, Markus Seidel, Andre Sznajder, Ali Eren Simsek, Tamer Elkafrawy, Pedro Galli Mercadante, Kenyi Hurtado Anampa, Luca Giommi, Efe Yigitbasi, Andrea Massironi, Andrey Starodumov, Jose Ruiz, Mario Pelliccioni, Caroline Collard, Alexei Safonov, WILLIAM FORD, Junghwan Goh, Spandan Mondal, Jingyan Li, German Ruben Martinez, Walter Snoeys, Evgueni Tcherniaev, Matteo Presilla, Stephen Mrenna, Jeremy Andrea, Panja Luukka, Saranya Samik Ghosh, Rogelio Reyes-Almanza, Joachim Mnich, Sandor Lokos, Darin Acosta, Karl Ehatäht, Aurelijus Rinkevicius, Frank Geurts, Isabel Josa Mutuberria, Junquan Tao, Paul Kyberd, Ece ASILAR, David D'Enterria, Sergey Polikarpov, Daniel Savoiu, Adish Vartak, Francesco Fienga, Jay Lawhorn, Arabella Martelli, Robert Cousins, Santeri Laurila, Jorma Tuominiemi, Andrey Popov, Jehad Mousa, Martin Grunewald, Paolo Spagnolo, Nicholas Wardle, Redwan Habibullah, Robert Klanner, Frank Golf, Isidro González Caballero, Crisostomo Sciacca, Oscar Gonzalez Lopez, Tahys Janssen, Jeremi Niedziela, Robert Bainbridge, Elizabeth Starling, Andrea Rizzi, Javier Alberto Murillo Quijada, Klaus Rabbertz, Luigi (Gigi) Rolandi, Federica Legger, Andrew Ivanov, ANKITA MEHTA, Ioannis Papadopoulos, Greg Landsberg, Malte Backhaus, Aliakbar Ebrahimi, INSEOK YOON, Sara Fiorendi, ANDREA PICCINELLI, Dmitry Kirpichnikov, Jennifer Ngadiuba, Tamas Almos Vami, Ivan Heredia de la Cruz, Maciej Malawski, Vuko Brigljević, Thomas McCauley, Vittorio Raoul Tavolaro, Pablo Martinez Ruiz del Arbol, Davide Fiorina, Kaur Sandeep, Reddy Pratap Gandrajula, Luca Malgeri, Leszek Grzanka, Peter Elmer, Lea Caminada, Kenneth Osterberg, Emil Sørensen Bols, Leandar Litov, Lata Panwar, Zhicai Zhang, Anton Stepennov, Arnd Meyer, Tatyana Dimova, Christophe Ochando, Alberto Ruiz Jimeno, J B Singh, Johannes Lange, Peter Wittich, Maria Cruz Fouz Iglesias, Korbinian Schweiger, Gaetano Marco Dallavalle, Pietro Faccioli, Rafael Eduardo Sosa Ricardo, Avi Yagil, Muhammad Gul, Jaana Heikkilä, Arne Christoph Reimers, Michele Arneodo, José Flix Molina, Javier Fernandez Menendez, Alexander Tapper, Valeria D'Amante, Sandra S. Padula, George Alverson, Lev Dudko, Juan Pablo Fernández Ramos, Karl Ecklund, Martin Delcourt, Salvatore Costa, Yacine Haddad, Paolo Meridiani, Ignacio Redondo, Marco Monteno, Gautier Hamel de Monchenault, Salvatore Rappoccio, Gerrit Van Onsem, Bora Akgun, Thomas Reis, Anna Colaleo, Marco CUFFIANI, Torben Lange, Lutz Feld, Varun Sharma, Gabriella Pásztor, Nicolas Stylianou, Sung-Won Lee, Joel Goldstein, Daniel Diaz, Paolo Azzurri, Oleg Filatov, Welathantri Dharmaratna, Benedikt Vormwald, Davide Zuolo, Ram Krishna Sharma, Ian Watson, Javier Mauricio Duarte, Vilius Cepaitis, Andreas Hinzmann, Nikkie Deelen, Matthias Kasemann, Manfred Paulini, Paolo Dini, Andre Frankenthal, Kevin Lannon, Mithat Kaya, Myriam Schönenberger, Florian Beaudette, Barbara Alvarez Gonzalez, Nuno Leonardo, Maxim Titov, Laurent Forthomme, Jose Enrique Palencia Cortezon, Rainer Wallny, Pietro Vischia, Schoefbeck Robert, Thea Aarrestad, Pieter David, Liuyao Zhang, Tae Jeong Kim, Marco Pieri, Sunil Manohar Dogra, Shabnam Jabeen, Guido Emilio Tonelli, Mar Capeans, Davide Di Croce, Ugur Kiminsu, J.F. Benitez, Luiz Mundim, Jason Lee, Jorgen D'Hondt, Maria Cepeda, Pallabi Das, Ksenia De Leo, Deborah Pinna, Morgan Lethuillier, Soureek Mitra, Bruno Lenzi, Sergio Novaes, Antonio Delgado Peris, Amina Zghiche, Pieter Everaerts, Gurpreet Singh Chahal, Hannu Siikonen, Mohammed Attia Mahmoud, André David Tinoco Mendes, Olga Evdokimov, Pierluigi Bortignon, Shubhanshu Chauhan, Simone Gennai, Freya Blekman, Furkan Dolek, Federica Maria Simone, Raffaele Gerosa, Benjamin Krikler, Geoffrey Hall, Eija Tuominen, Marko Dragicevic, Antonio Perez-Calero Yzquierdo, Nadezda Chernyavskaya, Mykhailo Dalchenko, Joona Juhani Havukainen, Biagio Rossi, Ibrahim Soner Zorbakir, Sandra Consuegra Rodriguez, Roberto Covarelli, Chiara Amendola, Christophorus Grab, Mojtaba Mohammadi Najafabadi, Henning Flaecher, Dilson De Jesus Damiao, Arthur Moraes, Lucas Taylor, Graham Wilson, Rui Xiao, Minsuk Kim, Alberto Sanchez-Hernandez, Tobias Robert Jakob Kramer, Marino Missiroli, Jan-Frederik Schulte, Fotios Ptochos, Shudhashil Bharthuar, Justin Williams, Helen Heath, Wolfgang Waltenberger, Henning Kirschenmann, Hannes Jung, Emrah Tiras, Camilo Carrillo Montoya, Alberto Zucchetta, Ralf Ulrich, Calandri Alessandro, Tahereh Sadat Niknejad, Guillelmo Gomez-Ceballos, Felipe Araujo, Kadri Ozdemir, Patrizia Azzi, Muhammad Alibordi, Vladimir Gavrilov, Johannes Haller, Kati Lassila-Perini, Abhijith Gandrakota, Konstantinos Theofilatos, Gouranga Kole, Eliza Melo da Costa, Andrea Davide Benaglia, Sebastian Wuchterl, Jesus Puerta Pelayo, Laura Martikainen, Ram Krishna Dewanjee, Christophe Delaere, Simon Regnard, Aaron Dominguez, Emanuele Usai, Matthew Herndon, Kenichi Hatakeyama, LUCA GUZZI, Alberto Belloni, Harrison Bertrand Prosper, Federico Siviero, Mariana Shopova, Mauro Donega, Abideh Jafari, Antonio Cassese, Federico De Guio, UTTIYA SARKAR, Aashaq Shah, Oliver Gutsche, Claudio Caputo, Mauro Emanuele Dinardo, Elisabetta Manca, Amedeo Staiano, Soumya Mukherjee, Thiago Rafael Fernandez Perez Tomei, Sudhir Malik, Clemens Lange, and Bożena Boimska
Subjects: General Physics and Astronomy
Published: 2022

42. Modern Orthodox Biblical Interpretation

Author: James Buchanan Wallace
Abstract: This chapter explores the reception of academic study of Scripture in the modern eastern Orthodox Church, focusing especially on the New Testament. After a historical overview of the reception of historical-critical interpretation, the chapter assesses several major attempts to formulate Orthodox hermeneutics in light of the neopatristic synthesis proposed by Florovsky, before turning to reactions against this trend. Critical study of Scripture, liberated from undue constraints of tradition, stands to make numerous contributions to Orthodox thought and practice, allowing us, for example, to hear the distinctive witness of each biblical text and combat anti-Semitism. Those interpreters who draw judiciously on Orthodox traditions in their biblical scholarship can contribute to academic interpretation by alerting readers to themes and/or perspectives that modern scholars often overlook. Orthodox biblical scholarship must remain a dialogue with scholars of various confessions and experts from related fields.
Published: 2022

43. Angular analysis of the decay B+ → K∗(892)+ μ + μ − in proton-proton collisions at s $$ \sqrt{\mathrm{s}} $$ = 8 TeV

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Van Onsem, Seth Cooper, Luigi Guiducci, Riccardo Paramatti, Andrea Giammanco, Priyanka Kumari, Martti Raidal, Gregory R Snow, Igor Volobouev, Hirak Bandyopadhyay, Marguerite Tonjes, David Mark Raymond, E. O. Olaiya, Christophe Delaere, Özlem Özçelik, Carlos Willmott, R. Del Burgo, Jorge Fraga, Daniel Savoiu, J. Kaspar, Victor Kim, S. May, Semra Turkcapar, Linda Finco, Y-J Lee, Alexander Spiridonov, Marko Dragicevic, Burin Asavapibhop, Xunwu Zuo, I. A. Melzer-Pellmann, Willem Verbeke, Armando Lanaro, Francesca Nessi-Tedaldi, C. Adloff, Yongho Jeong, Karl Gill, Bora Akgun, Awder Mohammed Ahmed, Mingshui Chen, W. A. T. Wan Abdullah, Jamal Rorie, George Karathanasis, Jason Gilmore, Daniel Bloch, Mohamed Rashad Darwish, James Bueghly, Matthew Nguyen, V. Rodríguez Bouza, E. Gurpinar Guler, Pedro G Mercadante, Hans-Christian Kaestli, Ankush Reddy Kanuganti, Marco Paganoni, Don Lincoln, Giuseppe Benedetto Cerati, Y. Choi, Brandon Allen, James D. 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Meyer, Ugo Gasparini, Veikko Karimäki, Tiziano Rovelli, Sharad Malik, Byeonghak Ko, Sara Fiorendi, Vasken Hagopian, Carlos Florez, G. M. Dallavalle, Bhargav Madhusudan Joshi, Georgios Krintiras, Matteo Presilla, Zeynep Demiragli, Marina Kolosova, Yalcin Guler, Roger Wolf, Lev Dudko, Jeremy Andrea, Tanmay Sarkar, Matthew Joyce, Alberto Ruiz-Jimeno, D. A. Perez Navarro, Ilaria Vai, Nicolas Postiau, Siqi Yuan, Marco Musich, Redwan Habibullah, Hong Ni, Hannes Sakulin, Tilman Rohe, Sara Nabili, Anastasia Karavdina, W. T. Ford, P. J. Fernández Manteca, Luca Guzzi, M. Bluj, Pierluigi Zotto, Robert Bainbridge, T. W. Wang, J. Ripoll Sau, Bożena Boimska, Kerem Cankocak, Andrew Levin, Anton Stepennov, Andrew Loeliger, Andrey Gribushin, Gobinda Majumder, H. Rejeb Sfar, Harrison Prosper, V. Smirnov, Jane Nachtman, Mario Deile, Stephen Robert Wagner, Sergio F Novaes, Samet Lezki, Morgan Lethuillier, Yasar Onel, Filippo Errico, Jean-Louis Faure, Brian Francis, Tamas Ferenc Csorgo, Paolo Checchia, Didar Dobur, Himal Acharya, S. Goy Lopez, Kadir Ocalan, P. Priyanka, David Walter, Amedeo Staiano, Alberto Messineo, John Almond, Austin Ball, S. M. Spanier, Vladimir Blinov, Nathaniel Odell, Ignacio Redondo, J. Berenguer Antequera, Yurii Maravin, Vladimir Gavrilov, Baokai Wang, Z. A. Liu, Jennifer Chu, Viktor Khristenko, M. Lu, Gaël Perrin, Umesh Joshi, H. Sert, Hongbo Liao, Aleko Khukhunaishvili, Daniele Ruini, Stefano Marcellini, Sonaina Undleeb, Michail Bachtis, Alexandra Tews, Bennett Marsh, Sa. Jain, Spandan Mondal, Luc Pape, William Arthur Nash, Vassili Kachanov, Jared Sturdy, Doris Eckstein, Achim Geiser, Batoul Diab, Moritz Guthoff, Marc Weber, Reham Aly, Javier Cuevas, L. Urda Gómez, Fatma Boran, Lara Zygala, Ioannis Papakrivopoulos, Laurent Thomas, Raffaella Tramontano, A. C. Le Bihan, Marcello Abbrescia, Metin Yalvac, Stephan Lammel, Daniel Noonan, D. Valsecchi, Sanjay Kumar, Danila Tlisov, Sourav Chatterjee, M. Alhusseini, R. M. Brown, John Alison, Aliakbar Ebrahimi, Leonardo Cristella, Hannes Jung, Markus Spanring, Mark Saunders, N. De Filippis, Victor Murzin, Q. Li, Arash Jofrehei, Samuel Nathan Webb, Katja Klein, Giovanni Mocellin, Ashish Sharma, A. M. Rossi, Evgueni Vlasov, Qianying Guo, A.-M. Lyon, Kurtis F Johnson, Greg P Heath, Th. Müller, R. Granier de Cassagnac, Alexey Kalinin, Maxime Gouzevitch, Alexander Zhokin, Andrea Beschi, Paul Sheldon, Yuichi Kubota, Andreas Albert, Martijn Mulders, Alexander Dierlamm, A. Rose, S. Kaur, Marius Metzler, A. Bragagnolo, Song-Ming Wang, Kamal Lamichhane, Mary Hadley, Martino Margoni, Daniel Guerrero, Roberto Mulargia, Dylan Gilbert, Michal Szleper, Chia-Ming Kuo, P. Major, Nadia Pastrone, Candan Dozen, Michael Wayne Arenton, J. Duarte, Marek Niedziela, Christoph Schäfer, Alexander Grohsjean, Siddhesh Sawant, S. Meola, Natale Demaria, Xuyang Gao, Shalini Thakur, Navid Rad, N. Turini, Susan Gascon, Gabriel Ramirez-Sanchez, James John Brooke, Cédric Prieels, F. Fiori, Gunther Roland, K. El Morabit, Zheng Wang, Ji Hwan Bhyun, Jeffrey Krupa, Illia Khvastunov, Lev Uvarov, Rajdeep Mohan Chatterjee, Martina Ressegotti, Oleksii Turkot, Michele Selvaggi, O. Behnke, Gulsen Onengut, Viktor Matveev, Lea Caminada, Rong-Shyang Lu, H. Lee, Carlo Civinini, Clemens Lange, K. Sandeep, Santiago Folgueras, George Alverson, Roman Kogler, Satoshi Hasegawa, A. Bodek, Oleksii Toldaiev, Andrew Wildridge, Mark Pesaresi, Claudia Ciocca, S. Shmatov, Kaitlin Salyer, F. Torres Da Silva De Araujo, Markus Seidel, Vineet Kumar, Simon Regnard, Jiajing Mao, Leonid Levchuk, Luca Scodellaro, Christos Roskas, Maria Cepeda, Jorgen D'Hondt, Daniela Schäfer, Tim Ziemons, T. Mitchell, Matthias Komm, Nadeesha Wickramage, Q. Ingram, L. Valencia Palomo, Salvatore Buontempo, Paul Avery, Lisa Benato, L. I. Estevez Banos, Quentin Python, Randy Ruchti, Joe Incandela, Luca Cadamuro, Colin Jessop, Cecilia Elena Gerber, Belforte, S., Candelise, V., Casarsa, M., Cossutti, F., DA ROLD, A., DELLA RICCA, G., Vazzoler, F., and ET AL (the CMS, Collaboration)
Subjects: Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Library science, QC770-798, 01 natural sciences, B physics, Hadron-Hadron scattering (experiments), Nuclear and particle physics. Atomic energy. Radioactivity, 0103 physical sciences, media_common.cataloged_instance, ddc:530, European union, 010306 general physics, Montenegro, China, Nuclear Experiment, media_common, Physics, 010308 nuclear & particles physics, PARTICLE PHYSICS, LARGE HADRON COLLIDER, CMS, Industrial research, Chinese academy of sciences, language.human_language, Physics and Astronomy, language, Physics::Accelerator Physics, Science policy, High Energy Physics::Experiment, Sri lanka, Portuguese
Abstract: BMBWF (Austria); FWF (Austria)Austrian Science Fund (FWF); FNRS (Belgium)Fonds de la Recherche Scientifique - FNRS; FWO (Belgium)FWO; CNPq (Brazil)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ); CAPES (Brazil)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES); FAPERJ (Brazil)Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ); FAPERGS (Brazil)Fundacao de Amparo a Ciencia e Tecnologia do Estado do Rio Grande do Sul (FAPERGS); FAPESP (Brazil)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); MES (Bulgaria); CERN; CAS (China)Chinese Academy of Sciences; MoST (China)Ministry of Science and Technology, China; NSFC (China)National Natural Science Foundation of China (NSFC); COLCIENCIAS (Colombia)Departamento Administrativo de Ciencia, Tecnologia e Innovacion Colciencias; MSES (Croatia); CSF (Croatia); RIF (Cyprus); SENESCYT (Ecuador); MoER (Estonia); ERC PUT (Estonia); ERDF (Estonia); Academy of Finland (Finland)Academy of Finland; MEC (Finland); HIP (Finland); CEA (France)French Atomic Energy Commission; CNRS/IN2P3 (France)Centre National de la Recherche Scientifique (CNRS); BMBF (Germany)Federal Ministry of Education & Research (BMBF); DFG (Germany)German Research Foundation (DFG); HGF (Germany); GSRT (Greece)Greek Ministry of Development-GSRT; NKFIA (Hungary); DAE (India)Department of Atomic Energy (DAE); DST (India)Department of Science & Technology (India); IPM (Iran); SFI (Ireland)Science Foundation Ireland; INFN (Italy)Istituto Nazionale di Fisica Nucleare (INFN); MSIP (Republic of Korea); NRF (Republic of Korea); MES (Latvia); LAS (Lithuania); MOE (Malaysia); UM (Malaysia); BUAP (Mexico); CINVESTAV (Mexico); CONACYT (Mexico)Consejo Nacional de Ciencia y Tecnologia (CONACyT); LNS (Mexico); SEP (Mexico); UASLP-FAI (Mexico); MOS (Montenegro); MBIE (New Zealand); PAEC (Pakistan); MSHE (Poland); NSC (Poland); FCT (Portugal)Portuguese Foundation for Science and TechnologyEuropean Commission; JINR (Dubna); MON (Russia); RosAtom (Russia); RAS (Russia)Russian Academy of Sciences; RFBR (Russia)Russian Foundation for Basic Research (RFBR); NRC KI (Russia); MESTD (Serbia); SEIDI (Spain); CPAN (Spain); PCTI (Spain); FEDER (Spain)European Commission; MOSTR (Sri Lanka); Swiss Funding Agencies (Switzerland); MST (Taipei); ThEPCenter (Thailand); IPST (Thailand); STAR (Thailand); NSTDA (Thailand); TUBITAK (Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); TAEK (Turkey)Ministry of Energy & Natural Resources - Turkey; NASU (Ukraine); STFC (U.K.)UK Research & Innovation (UKRI)Science & Technology Facilities Council (STFC); DOE (U.S.A.)United States Department of Energy (DOE); NSF (U.S.A.)National Science Foundation (NSF); Marie-Curie program (European Union); European Research Council (European Union)European Research Council (ERC)European Commission [675440, 724704, 752730, 765710]; Horizon 2020 Grant (European Union) [675440, 724704, 752730, 765710]; Leventis Foundation; A.P. Sloan FoundationAlfred P. Sloan Foundation; Alexander von Humboldt FoundationAlexander von Humboldt Foundation; Belgian Federal Science Policy OfficeBelgian Federal Science Policy OfficeEuropean Commission; Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium)Fonds de la Recherche Scientifique - FNRS; Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium)Institute for the Promotion of Innovation by Science and Technology in Flanders (IWT); F.R.S.-FNRS (Belgium) under the Excellence of Science -EOS -be.h projectFonds de la Recherche Scientifique - FNRS [30820817]; FWO (Belgium) under the Excellence of Science -EOS -be.h projectFWO [30820817]; Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [Z191100007219010]; Ministry of Education, Youth and Sports (MEYS) of the Czech RepublicMinistry of Education, Youth & Sports - Czech Republic; Deutsche Forschungsgemeinschaft (DFG) under Germany's Excellence StrategyGerman Research Foundation (DFG) [EXC 2121, 390833306]; Lendulet (Momentum) Program of the Hungarian Academy of Sciences (Hungary); Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (Hungary); New National Excellence Program UNKP (Hungary); NKFIA research grants (Hungary) [123842, 123959, 124845, 124850, 125105, 128713, 128786, 129058]; Council of Science and Industrial Research, IndiaCouncil of Scientific & Industrial Research (CSIR) - India; HOMING PLUS program of the Foundation for Polish Science (Poland); European Union, Regional Development Fund (Poland); Mobility Plus program of the Ministry of Science and Higher Education (Poland); National Science Center (Poland)National Science Centre, Poland [Harmonia 2014/14/M/ST2/00428, Opus 2014/13/B/ST2/02543, 2014/15/B/ST2/03998, 2015/19/B/ST2/02861, Sonata-bis 2012/07/E/ST2/01406]; National Priorities Research Program by Qatar National Research Fund; Ministry of Science and Higher Education (Russia) [02.a03.21.0005]; Tomsk Polytechnic University Competitiveness Enhancement Program; Programa Estatal de Fomento de la Investigacion Cientifica y Tecnica de Excelencia Maria de Maeztu [MDM-2015-0509]; Programa Severo Ochoa del Principado de Asturias; Thalis program - EU-ESF; Aristeia program - EU-ESF; Greek NSRFGreek Ministry of Development-GSRT; Rachadapisek Sompot Fund for Postdoctoral Fellowship (Thailand); Chulalongkorn University (Thailand)Chulalongkorn University; Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); Kavli Foundation; Nvidia Corporation; SuperMicro Corporation; Welch FoundationThe Welch Foundation [C-1845]; Weston Havens Foundation (U.S.A.)
Published: 2021

44. Precision measurement of the W boson decay branching fractions in proton-proton collisions at s=13 TeV

Author: Mikko Voutilainen, Stefaan Tavernier, Jordan Nash, Francisco Garcia, Raghunath Pradhan, Gabriella Pugliese, Alberto Escalante del Valle, Praveen Chandra Tiwari, Mate Csanad, Kadir Saygin, Kenneth Bloom, Pietro Govoni, Maximilian Pérez Prada, Arie Bodek, Riccardo Salvatico, Mikhail Dubinin, Andrea Cardini, Chang-Seong Moon, Ted Kolberg, Guenakh Mitselmakher, Kun Shi, Caglar Zorbilmez, Lorenzo Viliani, Ankush Reddy Kanuganti, Wesley Smith, Mikael Myllymäki, Hesham El Faham, Walaa Elmetenawee, Erhan Gülmez, Giovanni Abbiendi, Fabrizio Palla, Valentina Sola, Matthias Schröder, Cristina Riccardi, Sami Lehti, Abanti Ranadhir Sahasransu, Joseph Reichert, Jussi Viinikainen, Badder Marzocchi, Luke Kreczko, Hugues Lattaud, FLAVIA CETORELLI, Georgios Konstantinos Krintiras, Samet Lezki, Stefano Belforte, Maria Savina, Reza Goldouzian, Márton Bartók, Daniele Fasanella, Erika Garutti, Louis Moureaux, Nadia Pastrone, Danyer Pérez Adán, Muhammad Ahmad, Konstantin Androsov, Toni Sculac, Arun Kumar, Andreas Pfeiffer, Jorge Berenguer Antequera, Giuseppe Della Ricca, Eduard De La Cruz Burelo, Joern Schwandt, Christopher Tully, Luigi Calligaris, Wael HAJ AHMAD (Vael HAJAHMAD), Jennifer Ott, Francisco Javier Cuevas Maestro, Steffen Albrecht, Pablo Matorras-Cuevas, Prabhat Ranjan Pujahari, Alessandra Cappati, Alexander Belyaev, Florian Bury, James Buchanan, Roman Kogler, Andrea Giammanco, Marco Toliman Lucchini, Guenther Dissertori, Francesca Cavallari, José María Hernández Calama, Antonello Pellecchia, Efe Yazgan, Nils Faltermann, Yuri Gershtein, Sinan Sagir, Tomas Lindén, Halil Saka, Luca Cadamuro, Florencia Canelli, Simone Pigazzini, Armando Bermudez Martinez, Dmitri Konstantinov, Ksenia Shchelina, Cesar Augusto Bernardes, Bingran Wang, Qiang Li, Nicolò Trevisani, Tapio Lampén, Md Naimuddin, Barry Blumenfeld, Leonid Levchuk, Claudio Grandi, Giovanni Petrucciani, Dayong Wang, Marco Zanetti, Cristina Botta, Danilo Meuser, Martti Raidal, John Conway, Jaime Leon Holgado, Paolo Giacomelli, Jay R. Dittmann, Yalcin Guler, Agni Bethani, Marcin Konecki, Franco Ligabue, Alexander Grohsjean, Lourdes Urda, Mahmoud Moussa Abdelkhalek Gadallah, Silvano Tosi, Martina Malberti, Merve Ince Lezki, Jochen Schieck, Leonardo Cristella, Ernesto Migliore, Pritam Kalbhor, Silvia Goy Lopez, Ashish Sharma, Tommaso Diotalevi, Nikolaos Manthos, Lisa Benato, Suman Chatterjee, Émilien Chapon, Stéphane PERRIES, JUAN ALCARAZ MAESTRE, Antonio Vilela Pereira, Álvaro Navarro-Tobar, Thong Q. Nguyen, Zhenbin Wu, Maria Clemencia Mora Herrera, Zhengyun You, Agostino De Iorio, Ilaria Vai, Gilvan Alves, Sandeep Bhowmik, Cristina Fernández Bedoya, Nabin Poudyal, Markus Seidel, Andre Sznajder, Ali Eren Simsek, Tamer Elkafrawy, Pedro Galli Mercadante, Kenyi Hurtado Anampa, Luca Giommi, Efe Yigitbasi, Andrea Massironi, Andrey Starodumov, Jose Ruiz, Mario Pelliccioni, Caroline Collard, Alexei Safonov, WILLIAM FORD, Junghwan Goh, Spandan Mondal, Jingyan Li, German Ruben Martinez, Walter Snoeys, Evgueni Tcherniaev, Matteo Presilla, Stephen Mrenna, Jeremy Andrea, Panja Luukka, Saranya Samik Ghosh, Rogelio Reyes-Almanza, Joachim Mnich, Sandor Lokos, Darin Acosta, Karl Ehatäht, Aurelijus Rinkevicius, Frank Geurts, Isabel Josa Mutuberria, Junquan Tao, Paul Kyberd, Ece ASILAR, David D'Enterria, Daniel Savoiu, Adish Vartak, Francesco Fienga, Jay Lawhorn, Arabella Martelli, Robert Cousins, Santeri Laurila, Jorma Tuominiemi, Andrey Popov, Jehad Mousa, Martin Grunewald, Tirso Alejandro Gomez Espinosa, Paolo Spagnolo, Nicholas Wardle, Redwan Habibullah, Robert Klanner, Frank Golf, Isidro González Caballero, Crisostomo Sciacca, Oscar Gonzalez Lopez, Tahys Janssen, Jeremi Niedziela, Robert Bainbridge, Elizabeth Starling, Andrea Rizzi, Javier Alberto Murillo Quijada, Klaus Rabbertz, Luigi (Gigi) Rolandi, Federica Legger, Andrew Ivanov, ANKITA MEHTA, Ioannis Papadopoulos, Greg Landsberg, Malte Backhaus, Aliakbar Ebrahimi, INSEOK YOON, Sara Fiorendi, ANDREA PICCINELLI, Dmitry Kirpichnikov, Jennifer Ngadiuba, Tamas Almos Vami, Ivan Heredia de la Cruz, Maciej Malawski, Vuko Brigljević, Thomas McCauley, Vittorio Raoul Tavolaro, Pablo Martinez Ruiz del Arbol, Davide Fiorina, Kaur Sandeep, Reddy Pratap Gandrajula, Luca Malgeri, Leszek Grzanka, Peter Elmer, Lea Caminada, Kenneth Osterberg, Emil Sørensen Bols, Leandar Litov, Lata Panwar, Zhicai Zhang, Anton Stepennov, Arnd Meyer, Tatyana Dimova, Christophe Ochando, Gabriel Ramirez Sanchez, Alberto Ruiz Jimeno, J B Singh, Johannes Lange, Peter Wittich, Maria Cruz Fouz Iglesias, Korbinian Schweiger, Gaetano Marco Dallavalle, Pietro Faccioli, Rafael Eduardo Sosa Ricardo, Avi Yagil, Muhammad Gul, Jaana Heikkilä, Arne Christoph Reimers, Michele Arneodo, José Flix Molina, Javier Fernandez Menendez, Alexander Tapper, Valeria D'Amante, Sandra S. Padula, George Alverson, Lev Dudko, Juan Pablo Fernández Ramos, Karl Ecklund, Martin Delcourt, Salvatore Costa, Yacine Haddad, Paolo Meridiani, Ignacio Redondo, Marco Monteno, Gautier Hamel de Monchenault, Salvatore Rappoccio, Gerrit Van Onsem, Bora Akgun, Thomas Reis, Anna Colaleo, Marco CUFFIANI, Torben Lange, Lutz Feld, Varun Sharma, Gabriella Pásztor, Nicolas Stylianou, Sung-Won Lee, Joel Goldstein, Daniel Diaz, Paolo Azzurri, Oleg Filatov, Welathantri Dharmaratna, Benedikt Vormwald, Davide Zuolo, Ram Krishna Sharma, Ian Watson, Javier Mauricio Duarte, Vilius Cepaitis, Andreas Hinzmann, Nikkie Deelen, Matthias Kasemann, Manfred Paulini, Paolo Dini, Andre Frankenthal, Kevin Lannon, Mithat Kaya, Myriam Schönenberger, Florian Beaudette, Barbara Alvarez Gonzalez, Nuno Leonardo, Maxim Titov, Laurent Forthomme, Jose Enrique Palencia Cortezon, Rainer Wallny, Pietro Vischia, Schoefbeck Robert, Thea Aarrestad, Pieter David, Liuyao Zhang, Tae Jeong Kim, Marco Pieri, Sunil Manohar Dogra, Shabnam Jabeen, Guido Emilio Tonelli, Mar Capeans, Davide Di Croce, Ugur Kiminsu, J.F. Benitez, Luiz Mundim, Jason Lee, Jorgen D'Hondt, Maria Cepeda, Pallabi Das, Ksenia De Leo, Deborah Pinna, Morgan Lethuillier, Soureek Mitra, Bruno Lenzi, Sergio Novaes, Antonio Delgado Peris, Amina Zghiche, Pieter Everaerts, Gurpreet Singh Chahal, Hannu Siikonen, Mohammed Attia Mahmoud, André David Tinoco Mendes, Olga Evdokimov, Pierluigi Bortignon, Shubhanshu Chauhan, Simone Gennai, Ahmad Lotfy Abdelfattah Ahmad, Freya Blekman, Furkan Dolek, Federica Maria Simone, Raffaele Gerosa, Benjamin Krikler, Geoffrey Hall, Eija Tuominen, Marko Dragicevic, Antonio Perez-Calero Yzquierdo, Nadezda Chernyavskaya, Viola Sordini, Mykhailo Dalchenko, Joona Juhani Havukainen, Biagio Rossi, Ibrahim Soner Zorbakir, Pavel Parygin, Sandra Consuegra Rodriguez, Roberto Covarelli, Chiara Amendola, Christophorus Grab, Mojtaba Mohammadi Najafabadi, Henning Flaecher, Dilson De Jesus Damiao, Arthur Moraes, Lucas Taylor, Graham Wilson, Rui Xiao, Minsuk Kim, Francisco Matorras, Alberto Sanchez-Hernandez, Tobias Robert Jakob Kramer, Marino Missiroli, Jan-Frederik Schulte, Fotios Ptochos, Shudhashil Bharthuar, Justin Williams, Helen Heath, Wolfgang Waltenberger, Henning Kirschenmann, Hannes Jung, Emrah Tiras, Camilo Carrillo Montoya, Alberto Zucchetta, Ralf Ulrich, Calandri Alessandro, Tahereh Sadat Niknejad, Guillelmo Gomez-Ceballos, Felipe Araujo, Kadri Ozdemir, Patrizia Azzi, Muhammad Alibordi, Vladimir Gavrilov, Johannes Haller, Kati Lassila-Perini, Abhijith Gandrakota, Konstantinos Theofilatos, Gouranga Kole, Eliza Melo da Costa, Andrea Davide Benaglia, Sebastian Wuchterl, Jesus Puerta Pelayo, Laura Martikainen, Ram Krishna Dewanjee, Christophe Delaere, Simon Regnard, Aaron Dominguez, Emanuele Usai, Matthew Herndon, Kenichi Hatakeyama, LUCA GUZZI, Alberto Belloni, Harrison Bertrand Prosper, Federico Siviero, Mariana Shopova, Mauro Donega, Abideh Jafari, Antonio Cassese, Federico De Guio, UTTIYA SARKAR, Aashaq Shah, Oliver Gutsche, Claudio Caputo, Mauro Emanuele Dinardo, Elisabetta Manca, Amedeo Staiano, Soumya Mukherjee, Thiago Rafael Fernandez Perez Tomei, Sudhir Malik, Clemens Lange, and Bożena Boimska
Published: 2022

45. Greek and Byzantine Philosophical Exegesis

Author: Athanasios Despotis and James Buchanan Wallace
Subjects: Literature, business.industry, Philosophy, Exegesis, business, Byzantine architecture
Published: 2022

46. Introduction: The Early Christian Philosophy as a Way of Life and an Art of Exegesis

Author: Athanasios Despotis and James Buchanan Wallace
Published: 2022

47. Preliminary Material

Author: Athanasios Despotis and James Buchanan Wallace
Published: 2022

48. Search for new neutral Higgs bosons through the H → ZA → ℓ + ℓ − b b ¯ $$ \mathrm{H}\to \mathrm{ZA}\to {\ell}^{+}{\ell}^{-}\mathrm{b}\overline{\mathrm{b}} $$ process in pp collisions at s $$ \sqrt{s} $$ = 13 TeV

Author: S. Tkaczyk, David Stuart, Alice Mignerey, A. Benecke, Andreas Hinzmann, N. Zaganidis, Cecilia Elena Gerber, D. Domínguez Damiani, Minseok Oh, P. Das, Diego Beghin, Gregor Kasieczka, Y. Chao, Lesya Shchutska, Andrea Massironi, Raffaella Radogna, Thong Nguyen, I. Babounikau, A. Ranieri, Livia Soffi, R. B. Garg, Markéta Jansová, Francesco Navarria, Sotiroulla Konstantinou, David Overton, Sang Il Pak, Christopher Seez, Christopher George Tully, Rostyslav Shevchenko, Patrick Asenov, M. Weber, Alexander Belyaev, Claudio Campagnari, Teppo Mäenpää, Aruna Nayak, J. H. Yoo, Gervasio Gomez, Stephanie Brandt, A. Delgado Peris, Daniel Salerno, R. Mankel, Wolfgang Lohmann, Rohan Bhandari, Vinay Hegde, David Zou, Finn Feindt, Andrey Korytov, P. Chang, Eduardo De Moraes Gregores, Ashfaq Ahmad, Vladimir Korenkov, Ashim Roy, Th. Müller, Andre Frankenthal, Jan Krolikowski, Luiz Mundim, Duccio Abbaneo, Guido Tonelli, Cristina Biino, Gabriele Benelli, Patrizia Barria, Filip Moortgat, Konstantinos Kousouris, Arne Reimers, Joshua Bendavid, Nicanor Colino, Jian Sun, Alibordi Muhammad, Evgenii Tarkovskii, Stefanos Leontsinis, Marcin Konecki, Artur Lobanov, Nathaniel Pastika, Ada Solano, Artur Kalinowski, Chayanit Asawatangtrakuldee, Kyle Tos, Ioannis Evangelou, Geonhee Oh, C. K. Mackay, Lisa Borgonovi, L. V. Kardapoltsev, Amitabh Lath, Simon Kudella, Angela Mehta, A. Kasem, C. Martinez Rivero, Giorgio Apollinari, Andrés G Delannoy, Christopher Hill, Ulf Behrens, M. A. Shah, Zeljko Antunovic, Christoph Paus, Charles Mueller, Benjamin Mesic, F. Pandolfi, Teruki Kamon, James Buchanan, Maxim Pieters, A. Di Francesco, Ulrich Heintz, M. Kovac, Bjorn Burkle, B. De La Cruz, Jose F Benitez, Samuel Higginbotham, N. Vanegas Arbelaez, David Petyt, Erhan Gülmez, Kaori Maeshima, Martin Erdmann, Andrew Wisecarver, Tobias Pook, Patricia McBride, Krzysztof Doroba, Dylan Rankin, Andrew Brinkerhoff, Thomas Ferguson, Jose Flix, Didier Contardo, Vladimir Epshteyn, Sung Keun Park, Jay Hauser, A. Vilela Pereira, Dong Ho Moon, Tejinder Virdee, Salvatore Costa, Marco Alexander Harrendorf, Myriam Schönenberger, Fabrice Couderc, Atanu Modak, Marco Cipriani, Peter Elmer, Stephan Albert Wiederkehr, F. M. Stober, AllisonReinsvold Hall, Marcella Diemoz, M. Flechl, Mikhail Dubinin, G. Cucciati, J. Puerta Pelayo, Indara Suarez, Gregor Mittag, Fábio Lúcio Alves, Efe Yazgan, Frank Hartmann, Luciano Orsini, Nicolò Tosi, Camilla Galloni, Seth Conrad Zenz, Manfred Paulini, Jessica Prisciandaro, Fatma Boran, Ajeeta Khatiwada, Maciej Górski, Andrea Malara, A. A. Bin Anuar, Thorben Quast, Damir Lelas, Dajeong Jeon, Giacomo Sguazzoni, Javier Duarte, Adam Elwood, Angelo Giacomo Zecchinelli, Sami Lehti, Adish Vartak, David Bertsche, Valentina Mariani, Markus Stoye, Thomas Bergauer, Michael Planer, Christophe Royon, Elizabeth Sexton-Kennedy, Bobae Kim, Matthias Wolf, Wei Li, Zaixing Mao, Elena Voevodina, Ioannis Papakrivopoulos, Mikhail Danilov, Suat Ozkorucuklu, Wei Xie, Rainer Wallny, V. Drugakov, M. A. Bhat, C. S. Moon, Brian L Winer, Piero Giorgio Verdini, Vincenzo Daponte, M. Vidal Marono, Julia Thom, Finn Rebassoo, Carlos Willmott, R. Del Burgo, F. Mohamad Idris, C. Wissing, A. Castaneda Hernandez, E. Ayala, Wajid Ali Khan, Vladimir Mossolov, Andrew Parker, J. M. Vizan Garcia, Bugra Bilin, Kati Lassila-Perini, Piergiulio Lenzi, A. G. Stahl Leiton, Petra Merkel, Andrej Saibel, De Hua Zhu, Salvatore My, T. A. Gómez Espinosa, Daniele Bonacorsi, Nicholas Haubrich, James Dolen, Jean-Baptiste Sauvan, Gigi Rolandi, Malte Backhaus, Nicholas Wardle, Tao Huang, Paolo Ronchese, Laurent Thomas, Mark Derdzinski, Ivan Shvetsov, Igor Golutvin, Mircho Rodozov, Freya Blekman, Jennifer Ngadiuba, Volker Blobel, Ivan Amos Cali, A. Carvalho Antunes De Oliveira, L. Viliani, Pieter David, Mehmet Özgür Sahin, Donato Creanza, Badder Marzocchi, Olga Evdokimov, Junghwan Goh, Livio Fanò, O. Gonzalez Lopez, Sanjay Kumar Swain, Marc Dobson, Marc M Baarmand, Luca Pacher, Claire Shepherd-Themistocleous, Michael Wassmer, Antonis Agapitos, Thi Hien Doan, Daniel Denegri, Magda Diamantopoulou, Heiner Tholen, Hartmut Stadie, Daniele Trocino, Norbert Neumeister, Joshua Hardenbrook, Jennifer Chu, J. H. 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Sunar Cerci, Oliver Gutsche, Joachim Baechler, Maria Florencia Canelli, Fabrizio Ferro, Thomas Ferbel, Alexander Lanev, Stepan Obraztsov, Kamal Lamichhane, Mary Hadley, Claudio Grandi, Sébastien Gadrat, Martino Margoni, J. W. Gary, Sergey Troshin, Mayda Velasco, M. Melo De Almeida, T. Kress, Susan Dittmer, Kalyanmoy Chatterjee, Georgios Daskalakis, Pavel Bunin, Mario Deile, Stephen Robert Wagner, Sergei Gninenko, J. C. Freeman, Petr Mandrik, M. Shi, David D'Enterria, G. Bagliesi, Andreas Pfeiffer, Alessandra Cappati, Kreso Kadija, Chad Freer, Mykola Savitskyi, Stefan Piperov, Claudia Pistone, John Strologas, J. Fernandez Menendez, Senka Duric, Benjamin Tannenwald, Guler Karapinar, Hyunyong Kim, S. Petrushanko, C. Madrid, Helio Nogima, Kirill Skovpen, Young Ho Shin, P. Priyanka, W. H. Smith, Elif Asli Yetkin, Alberto Orso Maria Iorio, Felice Pantaleo, Chanwook Hwang, Mário Costa, Samuel May, Niladribihari Sahoo, Apichart Hortiangtham, Dezso Horvath, Giuseppe Latino, Emanuela Barberis, Christina Reissel, Ryan Mueller, W. A. T. Wan Abdullah, Jamal Rorie, Torben Dreyer, Valeria Botta, Alessia Tricomi, Nikolay Tyurin, M. De Palma, V. Monaco, Jason Gilmore, Marco Paganoni, Don Lincoln, Roumyana Hadjiiska, Igor Smirnov, Charles Maguire, J. R. González Fernández, Alexander Dierlamm, Matthew Kilpatrick, Alessandro Giassi, Vytautas Dudenas, Kerstin Hoepfner, Guo-Ming Chen, Vladimir Popov, Michael Dittmar, Menglei Sun, Arabella Martelli, Muhammad Ahmad, Michal Szleper, Roberto Chierici, Chia-Ming Kuo, Anshul Kapoor, Joona Havukainen, Süleyman Durgut, John Paul Chou, P. Major, Li Yuan, W. De Boer, Jory Sonneveld, Hafeez R Hoorani, Rishabh Uniyal, Alessandro Cardini, Nadia Pastrone, Daniel John Karmgard, Manfred Jeitler, Wolfgang Adam, Aleksandar Aleksandrov, Candan Dozen, Natalia Emriskova, Clemens Wöhrmann, Brian Paul Padley, Justin Williams, Jacopo Pazzini, C. Diez Pardos, Michael Wayne Arenton, Peter Robmann, Shalini Thakur, Tiziano Camporesi, James John Brooke, Cédric Prieels, Martina Ressegotti, P. Schütze, Brent Stone, Zhaozhong Shi, Nairit Sur, Oleksii Turkot, Michele Selvaggi, Owen Baron, Vivekanand Jha, Steve Schnetzer, Saranya Ghosh, Klaas Padeken, Louise Skinnari, Vito Palladino, Nural Akchurin, Hannu Siikonen, Suman Bala Beri, Helena Bialkowska, O. Behnke, Gulsen Onengut, Viktor Matveev, Yeonju Go, A. Vagnerini, Christophe Ochando, Gregory Iles, Nur Zulaiha Jomhari, Jacob Linacre, Yongbin Feng, Bernard Ille, H. Lee, C. F. González Hernández, Carlo Civinini, Clemens Lange, Ali Mohammadi, Dinko Ferencek, Frank Jensen, Marco Bozzo, Martina Malberti, Jay Dittmann, Renato Campanini, Francesco Santanastasio, Pawan Kumar Netrakanti, Evgueni Tcherniaev, K. A. Ulmer, Vitalii Okhotnikov, Petar Adzic, K. Sandeep, Santiago Folgueras, George Alverson, X. Y. Gao, Roman Kogler, Stoyan Stoynev, A. Sanchez-Hernandez, Tongguang Cheng, Satoshi Hasegawa, Benjamin Kreis, Maria Margherita Obertino, Alajos Makovec, A. Bodek, Oleksii Toldaiev, Rosamaria Venditti, W. J. Metzger, Engin Eren, P. Van Mulders, Michele Gallinaro, Mark Pesaresi, Claudia Ciocca, P. H. Butler, Tommaso Isidori, S. Shmatov, F. Torres Da Silva De Araujo, Giorgia Miniello, Vivian O'Dell, Peter Wittich, Valentin Sulimov, Francesco Fabozzi, Michal Olszewski, Giovanni Franzoni, Evrim Ersin Kangal, Ashok Kumar, Stefaan Tavernier, Markus Seidel, Diego Ciangottini, Vineet Kumar, Sergo Jindariani, J. Schwandt, M. Ruspa, Carlos Lourenco, Alexander Nehrkorn, Miroslav Bonchev, Ernesto Migliore, Najaf Amin, A. Braghieri, Caleb Smith, Florian Michael Pitters, G. Zevi Della Porta, Hans-Jürgen Simonis, Rachael Bucci, Pushpalatha C Bhat, Todd Adams, Andrew Wightman, Wit Busza, John Hakala, Stephanie Kwan, Alexander Bylinkin, Luca Perrozzi, Manfred Krammer, Kevin Sung, Andrey Popov, Vyacheslav Valuev, D. Kim, Daniel Teyssier, Sertac Ozturk, Konstanty Sumorok, Victor Perelygin, Manisha Lohan, Marc Dünser, Ren-Yuan Zhu, Pascal Vanlaer, Richard Breedon, I. Kashunin, Ravindra Kumar Verma, Alessandra Fanfani, E. Belchior Batista Das Chagas, J. Duarte Campderros, Frixos A Triantis, Andrew Askew, R. L. Lander, Nicholas Menendez, D. Pérez Adán, L. J. Gutay, M. Olmedo Negrete, Miao Hu, L. S. Durkin, Souvik Das, Gianni Masetti, Márton Bartók, Anne Dabrowski, Bryan Caraway, T. Y. Ling, Natalia Lychkovskaya, Federico Ambrogi, T.J. Williams, Marcos Cerrada, David Curry, V. Andreev, Grace Cummings, Francesco Fienga, Timo Peltola, Michael Schmitt, Carlo Rovelli, Silvio Donato, P. Rebello Teles, Amandeep Kaur Kalsi, Leonard Spiegel, Harry Cheung, Andrew Johnson, Peter Schleper, Zhen Hu, W. Haj Ahmad, Zoltan Laszlo Trocsanyi, J. Conway, D. Del Re, Vincent Lemaitre, Francesco Romeo, Robert Klanner, Paolo Giacomelli, Andrea Benaglia, K. Wichmann, P. Kyberd, Davide Fiorina, Paul Baillon, Artur Apresyan, Marc Besancon, Dinyar Rabady, Roy Montalvo, Wolfram Dietrich Zeuner, Saša Ceci, Darin Acosta, Kristian Allan Hahn, Malgorzata Kazana, R. Sharma, Rishika Bhardwaj, Simon Christoph Schuler, János Karancsi, S. Fonseca De Souza, Andrei Gritsan, Ali Celik, Simone Pigazzini, S. Slabospitskii, James Keaveney, Constantin Heidegger, Christopher Mcginn, K. Hurtado Anampa, Jian Wang, Daniel Robert Marlow, Natasa Raicevic, Gianni Zumerle, Anne A. Campbell, Sunil Bansal, Nicholas Smith, Thea Klaeboe Aarrestad, Haiyan Wang, S. Baur, Yves Sirois, Virgil E Barnes, Andrzej Novak, Graham Wilson, Jean-Charles Fontaine, Anton Dimitrov, Luciano Di Fiore, Werner Lustermann, Andromachi Tsirou, Mehmet Oglakci, Li Li, Alessio Ghezzi, P. Goldenzweig, Abideh Jafari, James Strait, Johannes Haller, Sarah Freed, Alicia Calderon, Christian Schomakers, Vadim Oreshkin, Francesca Cavallari, Seyed Mohsen Etesami, Sandra Oliveros, Alfredo Gurrola, Ufuk Guney Tok, Christopher Brew, M. J. Kim, Paolo Dini, S. Bheesette, Gintautas Tamulaitis, Lothar At Bauerdick, Leonardo Giannini, Weinan Si, Robert M Harris, Fabio Ravera, Maren Tabea Meinhard, Rogelio Reyes-Almanza, G. Correia Silva, Elliot Hughes, Gurpreet Singh Chahal, Andrew Buccilli, Charles C. Richardson, James Bowen, Arun Kumar, Daniele Spiga, J. Alexander, G. M. Bilei, Nikola Godinovic, Hualin Mei, Altan Cakir, Paolo Meridiani, Aron Soha, Simon Kurz, A. Bat, David Jonathan Hofman, Elizabeth Starling, Nan Lu, René Caspart, Elisabetta Manca, Shubham Pandey, Wei Shi, O. Rieger, Thomas Klijnsma, Christoph Grab, Henning Kirschenmann, Mikhail Gavrilenko, W. S. Hou, Nadezda Chernyavskaya, Juska Pekkanen, M. Franco Sevilla, B. Álvarez González, J. D. Ruiz Alvarez, Giacomo Bruno, Ian Mcalister, Damir Devetak, Michele Bianco, Antoine Lesauvage, W. E. Johns, Mariana Shopova, Eric Christian Chabert, Sean Flowers, Sandeep Bhowmik, Fengwangdong Zhang, A. Scribano, Yi-ting Duh, Boris Grynyov, Shengquan Tuo, Abhigyan Dasgupta, Zviad Tsamalaidze, Marguerite Tonjes, David Mark Raymond, Olivier Bondu, E. O. Olaiya, Christophe Delaere, J. Kaspar, Alex Kamenev, Victor Kim, Willem Verbeke, Armando Lanaro, Daniel Bloch, Mohamed Rashad Darwish, Vivek Sharma, Giuseppe Benedetto Cerati, Stavros Mallios, James D. Olsen, N. V. Krasnikov, Aobo Zhang, M. G. Albrow, J. S. Lange, Mario Maggi, J. D. Lewis, Benjamin Charles Radburn-Smith, Kevin Nash, Gourab Saha, Valentina Dutta, Vukasin Milosevic, Nikkie Deelen, Radia Redjimi, E. M. Da Costa, Prakash Thapa, A. Rinkevicius, Giovanni Abbiendi, Olmo Cerri, Olivier Davignon, Dmitri Konstantinov, Francisco Yumiceva, Ritva Kinnunen, Petar Maksimovic, Patrick Janot, Jan Tomsa, Thorsten Chwalek, Geng-Yuan Jeng, Irene Bachiller, Radek Zlebcik, Ivan Mikulec, Francesco Micheli, Gul Gokbulut, Debabrata Bhowmik, Adrian Perieanu, Savvas Kyriacou, Denis Rathjens, Alexandre Zabi, A. Meyer, Russell Richard Betts, Conor Henderson, A. Hervé, Prasenjit Mal, S. M. A. Ghiasi Shirazi, Marino Missiroli, C. Barth, Andrius Juodagalvis, Andrea Gozzelino, Kerstin Borras, Christina Snyder, Giacomo Fedi, Dong-Chul Son, Konstantin Matchev, J. J. Hollar, Jean-Marie Brom, Xavier Coubez, Liliana Teodorescu, P. Busson, Aaron Bundock, Katerina Lipka, Martin Kirakosyan, Georgios Bakas, F. Vazquez Valencia, Clément Leloup, Alexander Nikitenko, Jasvinder A. Singh, M. Rahmani, Egidio Longo, Francesca Ricci-Tam, Dipanwita Dutta, Meena Meena, Alexei Safonov, Ivan Marchesini, Janos Erö, Julia Velkovska, Sudha Ahuja, Halil Saka, Pietro Govoni, Mohsan Waseem Ather, Anna Stakia, Sébastien Wertz, Salvatore Rappoccio, L. Kreczko, Loukas Gouskos, L. M. Huertas Guativa, Maksim Azarkin, J. Alcaraz Maestre, Basil Schneider, Xavier Janssen, Nicolo Cartiglia, Shane Breeze, Iban Jose Cabrillo, Metin Yalvac, Stephan Lammel, Hugo Delannoy, Daniel Noonan, M. H.L.S. Wang, Sourav Chatterjee, M. Alhusseini, Aliakbar Ebrahimi, Markus Spanring, N. De Filippis, Evgueni Vlasov, Kurtis F Johnson, Greg P Heath, R. Granier de Cassagnac, Maxime Gouzevitch, Andrea Beschi, Marek Niedziela, Christoph Schäfer, Alexander Grohsjean, Dimitrios Tsitsonis, Lev Uvarov, Rajdeep Mohan Chatterjee, Junquan Tao, O. Kukral, Abhisek Datta, O. Hlushchenko, Tiziano Rovelli, Alberto Ruiz-Jimeno, Giuliana Galati, Didar Dobur, Himal Acharya, S. Goy Lopez, Austin Ball, S. M. Spanier, James S. Wright, Vladimir Blinov, Nathaniel Odell, Baokai Wang, Sa. Jain, Luc Pape, William Arthur Nash, Vassili Kachanov, Moritz Guthoff, Reham Aly, C. Scharf, Paolo Gunnellini, Juliet Ritchie Patterson, Joao Varela, Leander Litov, Jean-Pierre Merlo, Julie Malcles, Kithsiri Malagalage, Joanne Cole, A. K. Virdi, Eija Tuominen, Patrick Connor, Giovanna Selvaggi, Daniel Abercrombie, Gabor Istvan Veres, Hassan Abdalla, Daniel Pitzl, Sarah Catherine Eno, Jan-Frederik Schulte, Vladislav Borchsh, Joaquin Emilo Siado, Maksat Haytmyradov, Paolo Montagna, EmineGurpinar Guler, Hugues Brun, Pieter Everaerts, Titas Roy, Alexx Perloff, Roman Ryutin, Thomas Berger, J. Madhusudanan Sreekala, Othmane Bouhali, Federica Primavera, Roberto Carlin, Pierre Depasse, Vyacheslav Klyukhin, M. Van De Klundert, Victor Golovtcov, Luisa Benussi, Milan Stojanovic, Carlos Erice, H. Zhang, David Mason, Richard B. Lipton, Kurt Jung, Kristian Harder, Luigi Moroni, Luca Lista, D. Cutts, W. Snoeys, Michael Benjamin Andrews, Simone Paoletti, Abhijith Gandrakota, L. R. Sulak, M. A. Segura Delgado, Samandeep Sharma, Suchandra Dutta, J. A. Murillo Quijada, Giulio Mandorli, Anne-Marie Magnan, Wagner Carvalho, He He, Terhi Jarvinen, Greg Landsberg, Cécile Caillol, Manjit Kaur, David Krofcheck, J. P. Fernández Ramos, Anna Colaleo, S. Gianì, Andrew Evans, Roberto Leonardi, Alexander Barnyakov, Francesco Fiori, Yildiray Komurcu, J. L. Dulemba, Markus Merschmeyer, Eduardo Coelho, Ozlem Kaya, Sevil Salur, Y. Wang, Shuang-Nan Zhang, M. Fernandez, S. Somalwar, Jim Hanlon, D. Soldi, S. Sánchez Navas, Jose Chinellato, Richard Cavanaugh, Pedrame Bargassa, Bekhzod S Yuldashev, Nikolay Voytishin, K. H. M. Kwok, Kira Burt, Ivan Pozdnyakov, Ruchi Chudasama, Marco Rovere, Zehui Zhang, Eleni Erodotou, Marco Toliman Lucchini, Mauricio Thiel, Ilya Gorbunov, A. Baden, M. Barrio Luna, Peter Timothy Cox, Torben Lange, P. Martinez Ruiz del Arbol, Dan Quach, Michael Mulhearn, Ilya Kravchenko, Jeroen Hegeman, Rylan Conway, J. F. de Trocóniz, Maria Teresa Grippo, Anatoli Zarubin, Matthias Ulrich Mozer, O. Zenaiev, A. Morelos Pineda, James Wetzel, S. Seif El Nasr-storey, Johannes Brandstetter, Evan Ranken, B. McMaster, Fan Xia, Dietrich Liko, S. B. Oh, Alexander Malakhov, Mykhailo Dalchenko, Günter Flügge, Danyyl Brzhechko, M. Naimuddin, Tyler Ruggles, Jingyu Luo, Prafulla Kumar Behera, Robert Clare, Riccardo Andrea Manzoni, Christian Veelken, Yu. Andreev, Markus Klute, Lucas Torterotot, Patrizia Azzi, Joel Goldstein, Luciano Ristori, Milena Misheva, Luigi Calligaris, Kevin Pedro, Silvano Tosi, Ryan Heller, Maxime Guilbaud, Daniel Treille, Kelvin Mei, S. R. Dugad, D. De Jesus Damiao, Tamas Novak, Thomas Hebbeker, Paul Lecoq, A. M. Vargas Hernandez, German Martinez, A. De Roeck, A. David, Ksenia Shchelina, Albert M. Sirunyan, T. Susa, Cristina Botta, Viesturs Veckalns, K. Vellidis, E. Di Marco, Gaël Touquet, Jeremi Niedziela, Dario Bisello, Pascal Paganini, R. Walsh, Chiara Amendola, A. Di Florio, Jonas Rembser, A. De Wit, Frans Meijers, Stephen Trembath-Reichert, Hessamoddin Kaveh, Edward Scott, William Tabb, Cameron Bravo, and C. Neu
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Large Hadron Collider, Muon, 010308 nuclear & particles physics, Branching fraction, High Energy Physics::Phenomenology, Higgs physics, Electron, Computer Science::Digital Libraries, 01 natural sciences, Bottom quark, Hadron-Hadron scattering (experiments), 0103 physical sciences, Beyond Standard Model, Higgs boson, lcsh:QC770-798, ddc:530, High Energy Physics::Experiment, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, 010306 general physics, Boson, Research data
Abstract: This paper reports on a search for an extension to the scalar sector of the standard model, where a new CP-even (odd) boson decays to a Z boson and a lighter CP-odd (even) boson, and the latter further decays to a b quark pair. The Z boson is reconstructed via its decays to electron or muon pairs. The analysed data were recorded in proton-proton collisions at a center-of-mass energy $$ \sqrt{s} $$ s = 13 TeV, collected by the CMS experiment at the LHC during 2016, corresponding to an integrated luminosity of 35.9 fb−1. Data and predictions from the standard model are in agreement within the uncertainties. Upper limits at 95% confidence level are set on the production cross section times branching fraction, with masses of the new bosons up to 1000 GeV. The results are interpreted in the context of the two-Higgs-doublet model.
Published: 2020

49. Factor's that impact on women's decision-making around prenatal genomic tests: An international discrete choice survey

Author: James Buchanan, Melissa Hill, Caroline M. Vass, Jennifer Hammond, Sam Riedijk, Jasmijn E. Klapwijk, Eleanor Harding, Stina Lou, Ida Vogel, Lisa Hui, Charlotta Ingvoldstad‐Malmgren, Maria Johansson Soller, Kelly E. Ormond, Mahesh Choolani, Qian Zheng, Lyn S. Chitty, Celine Lewis, Clinical Genetics, and Human genetics
Subjects: Pregnancy, Prenatal Diagnosis, Surveys and Questionnaires, Obstetrics, Gynecology and Reproductive Medicine, Humans, Obstetrics and Gynecology, Female, Patient Preference, Reproduktionsmedicin och gynekologi, Genetic Testing, Genomics, Choice Behavior, Genetics (clinical)
Abstract: Objective We conducted a survey-based discrete-choice experiment (DCE) to understand the test features that drive women's preferences for prenatal genomic testing, and explore variation across countries. Methods Five test attributes were identified as being important for decision-making through a literature review, qualitative interviews and quantitative scoring exercise. Twelve scenarios were constructed in which respondents choose between two invasive tests or no test. Women from eight countries who delivered a baby in the previous 24 months completed a DCE presenting these scenarios. Choices were modeled using conditional logit regression analysis. Results Surveys from 1239 women (Australia: n = 178; China: n = 179; Denmark: n = 88; Netherlands: n = 177; Singapore: n = 90; Sweden: n = 178; UK: n = 174; USA: n = 175) were analyzed. The key attribute affecting preferences was a test with the highest diagnostic yield (p < 0.01). Women preferred tests with short turnaround times (p < 0.01), and tests reporting variants of uncertain significance (VUS; p < 0.01) and secondary findings (SFs; p < 0.01). Several country-specific differences were identified, including time to get a result, who explains the result, and the return of VUS and SFs. Conclusion Most women want maximum information from prenatal genomic tests, but our findings highlight country-based differences. Global consensus on how to return uncertain results is not necessarily realistic or desirable., Prenatal Diagnosis, 42 (7), ISSN:0197-3851, ISSN:1097-0223
Published: 2022
Full Text: View/download PDF

50. The knowledge economy: Key to sustainable development?

Author: Lukas Rezny, Petra Maresova, and James Buchanan White
Subjects: Sustainable development, Economics and Econometrics, Index (economics), Natural resource economics, Knowledge economy, 05 social sciences, 0211 other engineering and technologies, Resource efficiency, 02 engineering and technology, Resource depletion, Natural resource, 0502 economics and business, Sustainability, Economics, 021108 energy, 050207 economics, Environmental degradation
Abstract: A perfect storm of resource depletion and environmental degradation looms as the world’s biggest economies are plagued by low or even negative growth rates. The knowledge economy is often presented as a way of a radical societal transformation to achieve both higher and sustainable economic growth, and as a way out of the predicament of increasing resource scarcity and climate disruption. This paper explores the relationship between the knowledge economy index and consecutive economic growth rates along with various indicators of resource consumption to determine the relative success of this supposedly unique mode of economic development. Our findings show the failure of advanced knowledge economies to grow in the post-2008 period. We have not found any evidence of higher resource efficiency of advanced knowledge economies when their resource consumption is assessed using the material footprint. Through comparison of coal and oil consumption with changes in knowledge economy rankings from 1995 to 2012, we found no regular pattern of diminishing reliance on these increasingly scarce and expensive natural resources by successfully developing knowledge economies.
Published: 2019

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