65 results on '"James Au"'
Search Results
2. Object Segmentation and Tracking Using Video Locales.
- Author
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James Au, Ze-Nian Li, and Mark S. Drew
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- 2002
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3. Classification of summarized videos using hidden markov models on compressed chromaticity signatures.
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Cheng Lu 0009, Mark S. Drew, and James Au
- Published
- 2001
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4. Application of EXPLAN theory to spontaneous speech control.
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Peter Howell and James Au-Yeung
- Published
- 2001
5. A nociceptor-specific RNAi screen in Drosophila larvae identifies RNA-binding proteins that regulate thermal nociception
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Amber Dyson, Gita Gajjar, Katherine C. Hoffman, Dakota Lewis, Sara Palega, Erik Rangel Silva, James Auwn, and Andrew Bellemer
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Drosophila ,Nociception ,RNA-binding Proteins ,Gene Expression ,Neurobiology ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Nociception is the process by which sensory neurons detect and encode potentially harmful environmental stimuli to generate behavioral responses. Nociceptor neurons exhibit plasticity in which their sensitivity to noxious stimuli and subsequent ability to drive behavior may be altered by environmental conditions, injury, infection, and inflammation. In some cases, nociceptor sensitization requires regulated changes in gene expression, and recent studies have indicated roles for post-transcriptional mechanisms in regulating these changes as an aspect of nociceptor plasticity. The larvae of Drosophila melanogaster have been developed as a powerful model for studying mechanisms of nociception, nociceptor plasticity, and nociceptor development. Diverse RNA-binding proteins regulate the development and morphology of larval nociceptors, implying important roles for post-transcriptional regulation of gene expression in these neurons, but the importance of these mechanisms for nociceptive behavior has not been investigated systematically. In this study, we conducted a nociceptor-specific RNAi screen of 112 candidate RNA-binding protein genes to identify those that are required for normal sensitivity to noxious thermal stimuli. The screen and subsequent validation experiments identified nine candidate genes (eIF2α, eIF4A, eIF4AIII, eIF4G2, mbl, SC35, snf, Larp4B and CG10445) that produce defects in nociceptive response latency when knocked down in larval nociceptors. Some of the genes identified have well-understood roles in the regulation of translation initiation and regulation of nociceptor sensitization in vertebrate and invertebrate animal models, suggesting an evolutionarily conserved role for these mechanisms in regulating nociceptor sensitivity. Other screen isolates have previously described roles in regulating nociceptor morphology and mRNA processing, but less clear roles in regulating nociceptor function. Further studies will be necessary to identify the mechanisms by which the identified RNA-binding proteins regulate sensory neuron function and the identities of the mRNAs that they target.
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- 2025
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6. Clustering of compressed illumination-invariant chromaticity signatures for efficient video summarization.
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Mark S. Drew and James Au
- Published
- 2003
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7. Video keyframe production by efficient clustering of compressed chromaticity signatures (poster session).
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Mark S. Drew and James Au
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- 2000
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8. The Making of Second Life
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Wagner James Au
- Published
- 2009
9. Taking New World Notes: An embedded journalist's rough guide to reporting from inside the Internet's next evolution.
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Wagner James Au
- Published
- 2005
10. Kantian Cosmopolitan Ideal in Disciplining the World Literature: Cosmopolitanism in Hong Kong Poetry in the Early 1990s
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James Au Kin-pong
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Literature ,World literature ,Ideal (set theory) ,Poetry ,Aesthetics ,business.industry ,Philosophy ,Cosmopolitanism ,business - Published
- 2017
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11. A method for evaluating antiscalant retardation of crystal nucleation and growth on RO membranes
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Eric Lyster, Myung-Man Kim, James Au, and Yoram Cohen
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Supersaturation ,Gypsum ,Chemistry ,Nucleation ,Mineralogy ,Filtration and Separation ,Crystal growth ,engineering.material ,Biochemistry ,Desalination ,Membrane ,Chemical engineering ,engineering ,General Materials Science ,Physical and Theoretical Chemistry ,Reverse osmosis ,Scaling - Abstract
An experimental method was developed for quantifying mineral scale nucleation and growth on RO membranes enabling comparison of the effectiveness of antiscalants in retarding mineral scale formation. Mineral scale growth and inhibition was evaluated, for calcium sulfate dihydrate (gypsum) as a model scalant, from direct visual observations of crystal growth on the membrane surface in a plate-and-frame RO cell. Comparison of membrane scaling with and without the use of antiscalants was carried out based on RO scaling tests conducted under identical operating conditions with respect to the initial flux and crossflow velocity, at identical initial concentration fields within the RO membrane channel and at the membrane surface. The range of gypsum saturation index (SIg) at the membrane surface was 1.3–2.3 enabling determination of gypsum scaling for the above SIg range from a single RO scaling test, given direct observation of crystal nucleation and growth on the membrane surface. The present work demonstrates that it is possible to distinguish antiscalants modes of scale inhibition and corresponding scale suppression effectiveness, over a reasonable range of solution supersaturation. The current approach introduces antiscalant crystal nucleation and growth retardation factors that can aid in the development, selection and dose optimization of antiscalants for use in RO desalination.
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- 2010
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12. Coupled 3-D hydrodynamics and mass transfer analysis of mineral scaling-induced flux decline in a laboratory plate-and-frame reverse osmosis membrane module
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James Au, Eric Lyster, Francesc Giralt, Yoram Cohen, and Robert Rallo
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Supersaturation ,Gypsum ,Chemistry ,Flux ,Thermodynamics ,Mineralogy ,Filtration and Separation ,engineering.material ,Biochemistry ,Physics::Geophysics ,Membrane ,Mass transfer ,engineering ,General Materials Science ,Physical and Theoretical Chemistry ,Reverse osmosis ,Scaling ,Concentration polarization - Abstract
A 3-D (3-dimensional) numerical modeling approach to analyze the coupling of mineral scale, concentration polarization and permeate flux was developed and demonstrated for a gypsum membrane scaling test in a plate-and-frame RO membrane module geometry. The impact of concentration polarization on mineral gypsum scaling, and in turn the impact of mineral scale on the concentration polarization field, were explored via 3-D finite-element numerical solutions of the coupled fluid hydrodynamics and solute mass transfer equations, along with detailed experimental data on the extent and location of mineral scale. Numerical simulations of the concentration field for a scale-free membrane revealed that the regions of highest supersaturation with respect to calcium sulfate corresponded to regions of highest gypsum scale density, as observed through real-time imaging of the membrane surface in the gypsum scaling test. 3-D simulations of the concentration field in the presence of mineral scale revealed that the concentration polarization modulus and permeate flux were largely unaffected in contiguous scale-free regions of the membrane. However, near and just downstream of individual crystal formations, the local concentration polarization modulus decreased (by ∼5%) and the permeate flux increased (by ∼2%) relative to the same positions in the absence of scale. The model-calculated and experimental permeate flux decline agreed closely with an average absolute error of 1.8%. The present study suggests that flux decline due to mineral scaling can be reasonably described by the surface blockage mechanism.
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- 2009
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13. Impact of Conventional Water Treatment Coagulants on Mineral Scaling in RO Desalting of Brackish Water
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Fredrick W. Gerringer, Julius Glater, Anditya Rahardianto, James Au, Myung-Man Kim, Christopher J. Gabelich, and Yoram Cohen
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Potential impact ,Mineral ,Brackish water ,General Chemical Engineering ,chemistry.chemical_element ,General Chemistry ,Calcium ,Pulp and paper industry ,Desalination ,Industrial and Manufacturing Engineering ,Barium sulfate ,chemistry.chemical_compound ,chemistry ,parasitic diseases ,Water treatment ,Reverse osmosis - Abstract
The potential impact of coagulants on mineral scaling in reverse osmosis (RO) feed treatment of brackish water was assessed experimentally, with respect to calcium sulfate and barium sulfate scalin...
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- 2009
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14. Counterfactual and alternative histories as design practice
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James Auger and Julian Hanna
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Design pedagogy ,speculative design ,critical design ,counterfactual history ,alternative history ,Drawing. Design. Illustration ,NC1-1940 ,Engineering design ,TA174 - Abstract
The version of design that was shaped and perfected during the 20th Century played a huge role in the making of the modern (global northern) world. Whilst design’s potential as a contributor to the making of worlds is clear, its methods, metrics and purposes have led to a world that is increasingly revealed as fragile, broken and unsustainable. In other words, design today is complicit in the breaking of the world – this essay describes a practice-based design research approach to the making of other worlds. Borrowing from the literary approaches of counterfactual and alternative histories and imaginative fiction, it aims to facilitate the development of new approaches to design, informed through alternative ideologies, methods and motivations. The counterfactual approach allows us to imagine other ways to be, in this case through the application of alternative value systems, a non-additive approach to technology and a removal of the constraints imposed by history. The approach can be summed up as follows: • Definition of the theme followed by a broad mapping of its related systems. • The creation of a counterfactual timeline based on a different outcome of one or more of the events identified on the real timeline. • The design of things along the new timeline: hypothetical products, advertising campaigns, images, texts – evidence of the new value system in action. The most vital use of counterfactuals in design is to allow different voices to emerge that were silenced by the dominant, hegemonic or “standard” narrative(s). As we argue in this essay, illustrated with examples from past and current student projects, alternative histories can open up valuable future paths and create space for rich new imaginaries to flourish.
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- 2023
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15. Phonetic complexity and stuttering in Spanish
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Peter Howell and James Au-Yeung
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Adult ,Male ,Linguistics and Language ,medicine.medical_specialty ,Stuttering ,Adolescent ,Audiology ,Affect (psychology) ,Article ,Language and Linguistics ,Speech and Hearing ,Age groups ,Phonetics ,medicine ,Humans ,Statistical analysis ,Child ,Aged ,Age differences ,Middle Aged ,Linguistics ,Spain ,Female ,Speech disorder ,medicine.symptom ,Psychology ,Word (group theory) - Abstract
The current study investigated whether phonetic complexity affected stuttering rate for Spanish speakers. The speakers were assigned to three age groups (6-11, 12-17 and 18 years plus) that were similar to those used in an earlier study on English. The analysis was performed using Jakielski's (1998) Index of Phonetic Complexity (IPC) scheme in which each word is given an IPC score based on the number of complex attributes it includes for each of eight factors. Stuttering on function words for Spanish did not correlate with IPC score for any age group. This mirrors the finding for English that stuttering on these words is not affected by phonetic complexity. The IPC scores of content words correlated positively with stuttering rate for 6-11 year old and adult speakers. Comparison was made between the languages to establish whether or not experience with the factors determines the problem they pose for speakers (revealed by differences in stuttering rate). Evidence was obtained that four factors found to be important determinants of stuttering on content words in English for speakers aged 12 and above, also affected Spanish speakers. This occurred despite large differences in frequency of usage of these factors. It is concluded that phonetic factors affect stuttering rate irrespective of a speaker's experience with that factor.
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- 2007
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16. Phonetic difficulty and stuttering in English
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James Au-Yeung, Peter Howell, Scott J. Yaruss, and Kevin A. Eldridge
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Male ,Consonant ,Linguistics and Language ,Stuttering ,Adolescent ,Severity of Illness Index ,Article ,Language and Linguistics ,Speech and Hearing ,Fluency ,Phonetics ,Similarity (psychology) ,medicine ,Humans ,Articulation Disorders ,Early childhood ,Child ,United States ,Linguistics ,Female ,Speech disorder ,medicine.symptom ,Psychology ,Consonant cluster ,Cognitive psychology - Abstract
Previous work has shown that phonetic difficulty affects older, but not younger, speakers who stutter and that older speakers experience more difficulty on content words than function words. The relationship between stuttering rate and a recently-developed index of phonetic complexity (IPC, Jakielski, 1998) was examined in this study separately for function and content words for speakers in 6-11, 11 plus-18 and 18 plus age groups. The hypothesis that stuttering rate on the content words of older speakers, but not younger speakers, would be related to the IPC score was supported. It is argued that the similarity between results using the IPC scores with a previous analysis that looked at late emerging consonants, consonant strings and multiple syllables (also conducted on function and content words separately), validates the former instrument. In further analyses, the factors that are most likely to lead to stuttering in English and their order of importance were established. The order found was consonant by manner, consonant by place, word length and contiguous consonant clusters. As the effects of phonetic difficulty are evident in teenage and adulthood, at least some of the factors may have an acquired influence on stuttering (rather than an innate universal basis, as the theory behind Jakielski's work suggests). This may be established in future work by doing cross-linguistic comparisons to see which factors operate universally. Disfluency on function words in early childhood appears to be responsive to factors other than phonetic complexity.
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- 2006
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17. Syntactic development in ‘ uent children, children who stutter, and children who have English as an additional language
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Stephen Davis, James Au-Yeung, and Peter Howell
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Linguistics and Language ,Turkish ,First language ,Article ,Language and Linguistics ,Education ,Developmental psychology ,030507 speech-language pathology & audiology ,03 medical and health sciences ,Speech and Hearing ,Subject (grammar) ,Developmental and Educational Psychology ,0501 psychology and cognitive sciences ,Control (linguistics) ,05 social sciences ,Syntax ,language.human_language ,Linguistics ,Test (assessment) ,Clinical Psychology ,language ,Grammaticality ,0305 other medical science ,Psychology ,Mean length of utterance ,050104 developmental & child psychology - Abstract
Children aged between two and 10 years were assessed on a new reception of syntax test (ROST). Validations of the test are reported for monolingual ‘ uent control children under five (by examining the relationship with mean length of utterance and the Oxford Communication Development Inventory) and for over fives (relationship with a new judgement of grammaticality test using syntactic categories common to the two tests). Performance of these children was compared with performance of children who stutter and children with English as an additional language. In this study, the test was divided into under-five and over-five forms. Any young child progressing to the over-five syntactic categories, or any older child doing the under-five syntactic categories was dropped from the analysis. ROST scores prepared according to this scheme led to no differences between the control and either of the subject groups tested. However, compared to controls, the children with English as an additional language (but not children who stutter) had a significantly higher proportion of children above five who did the under-five categories (and were, therefore, excluded from the analyses). The higher proportion of children who did the under-five syntactic categories in the English as an additional language group indicates that group scores would have been lower if their syntax results had been included in the analysis. Further analyses provided some evidence that two groups with English as an additional language (Turkish and Cantonese speakers) did not perform any better on selected syntactic categories in their native language compared with their performance in English.
- Published
- 2003
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18. An Automatic Video Classification System Based on a Combination of HMM and Video Summarization
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Mark S. Drew, Cheng Lu, and James Au
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Video post-processing ,Computer science ,business.industry ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Pattern recognition ,computer.file_format ,Smacker video ,Automatic summarization ,Video compression picture types ,Uncompressed video ,Video tracking ,Computer vision ,Artificial intelligence ,Multiview Video Coding ,business ,computer ,Software ,Block-matching algorithm - Abstract
As digital libraries and video databases grow, we need methods to assist us in the synthesis and analysis of digital video. Since the information in video databases can be measured in thousands of gigabytes of uncompressed data, tools for efficient summarizing and indexing of video sequences are indispensable. In this paper, we present a method for effective classification of different types of videos that makes use of a video summarization that is in the form of a storyboard of keyframes. To produce the summarization, we first generate a universal basis on which to project a video frame that effectively reduces any video to the same lighting conditions. Each frame is represented by a compressed chromaticity signature. We then set out a multi-stage hierarchical clustering method to efficiently summarize a video. Finally we classify TV videos using a trained Hidden Markov Model that utilizes the compressed chromaticity signatures as well as temporal features of videos derived from their keyframe summaries.
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- 2003
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19. Non-word reading, lexical retrieval and stuttering: Comments on Packman, Onslow, Coombes and Goodwin (2001)
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James Au-Yeung and Peter Howell
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Linguistics and Language ,Stuttering ,media_common.quotation_subject ,Lexicalization ,Dyslexia ,Phonology ,Lexical definition ,medicine.disease ,Vocabulary ,Article ,Language and Linguistics ,Linguistics ,Speech and Hearing ,Reading ,Phonetics ,Covert ,Reading (process) ,medicine ,Humans ,Speech disorder ,medicine.symptom ,Psychology ,media_common - Abstract
A recent study by Packman, Onslow, Coombes and Goodwin (2001) employed a non-word-reading paradigm to test the contribution of the lexical retrieval process to stuttering. They consider that, with this material, the lexical retrieval process could not contribute to stuttering and that either anxiety and/or the motor demand of reading are the governing factors. This paper will discuss possible processes underlying non-word reading and it argues that the conclusion arrived at by Packman et al. does not stand up to close scrutiny. In their introduction, the authors acknowledge that the lexicalization process involves retrieval and encoding of words. In a non-word-reading task, the word retrieval component is eliminated. The possibility that the encoding component of the lexicalization process leads to stuttering is, however, completely ignored by the authors when they attribute stuttering to motor demands. As theories put forward by Postma and Kolk (the Covert Repair Hypothesis, 1993) and Howell and Au-Yeung (the EXPLAN theory, 2002) argue heavily for the role of the phonological encoding processes in stuttering, Packman et al.'s work does not evaluate such theories. Theoretical issues aside, Packman et al.'s arguments about reading rate and stuttering rate based on reading time is also questionable.
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- 2002
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20. Clinical evolution: Moving forward by looking back
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James Au-Yeung and Frances M. Cook
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Male ,Linguistics and Language ,Stuttering therapy ,Speech-Language Pathology ,Psychotherapist ,Cognitive Behavioral Therapy ,business.industry ,Cognitive Neuroscience ,MEDLINE ,Experimental and Cognitive Psychology ,Professional-Patient Relations ,Stuttering ,Speech Therapy ,LPN and LVN ,Anxiety Disorders ,Language and Linguistics ,Speech and Hearing ,Patient satisfaction ,Text mining ,Patient Satisfaction ,Humans ,Female ,Psychology ,business - Published
- 2011
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21. Lexicalization and Stuttering
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Peter Howell and James Au-Yeung
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Linguistics and Language ,Vocabulary ,Stuttering ,Lexicalization ,media_common.quotation_subject ,Verb ,medicine.disease ,Article ,Language and Linguistics ,Linguistics ,Speech and Hearing ,Action (philosophy) ,Noun ,medicine ,Language disorder ,medicine.symptom ,Psychology ,Utterance ,media_common - Abstract
Prins, Main, and Wampler (1997) examined whether people who stutter have slower lexical access time than people who do not stutter. Their study was based on the two-stage model of lexical access proposed by Kempen and Huijbers (1983). According to Kempen and Huijbers' model, lexicalization time (Lex) is divided into two separate non-overlapping stages: L1, lexicalization for retrieving semantic and syntactic information and L2, lexicalization for accessing the word form (articulatory plan). A picture-naming experiment was used to test the validity of their model. Kempen and Huijbers showed that the speech-onset time in naming an actor (a noun) was shorter than that in naming an action (a verb). This is shown in sections (a) and (b) of Figure 1 by the length of the lines along the time axis (the abscissa). The time to speech onset when naming both the actor and the action (noun plus verb), shown in Figure 1(c), was longer than that for naming just the actor. This showed that lexical access for the verb commenced before speech onset of the noun plus verb (N+V) utterance. The speech-onset time in naming both the actor and the action was, however, found to be approximately equal to that for naming just the action. Kempen and Huijbers argued that the L1 lexicalization time for both the noun and the verb overlapped, and the speech-onset time was dominated by the longer of the two, the L1 lexicalization time for the verb. This is shown in the L1-labelled sections on the left of Figure 1(c). When naming both the actor and the action, L2 lexicalization of the noun needs to be completed before speech onset. L2 lexicalization of the verb is assumed to occur in sequence after the L2 lexicalization of the noun, in parallel with the motor execution of the noun.
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- 1999
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22. Game Design Secrets
- Author
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Wagner James Au and Wagner James Au
- Subjects
- Video games--Design, Video games--Programming
- Abstract
Design great Facebook, iOS, and Web games and learn from the experts what makes a game a hit! This invaluable resource shows how to put into action the proven design and marketing techniques from the industry's best game designers, who all started on a small scale. The book walks novice and experienced game designers through the step-by-step process of conceptualizing, designing, launching, and managing a winning game on platforms including Facebook, iOS, and the Web. The book is filled with examples that highlight key design features, explain how to market your game, and illustrate how to turn your design into a money-making venture. Provides an overview of the most popular game platforms and shows how to design games for each Contains the basic principles of game design that will help promote growth and potential to generate revenue Includes interviews with top independent game developers who reveal their success secrets Offers an analysis of future trends that can open (or close) opportunities for game designers Game Design Secrets provides aspiring game designers a process for planning, designing, marketing, and ultimately making money from new games.
- Published
- 2012
23. Utterance rate and linguistic properties as determinants of lexical dysfluencies in children who stutter
- Author
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Lesley Pilgrim, James Au-Yeung, and Peter Howell
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Male ,Auditory feedback ,Vocabulary ,Stuttering ,Acoustics and Ultrasonics ,media_common.quotation_subject ,Linguistics ,Tone (literature) ,Article ,nervous system diseases ,Variation (linguistics) ,Arts and Humanities (miscellaneous) ,Duration (music) ,medicine ,Humans ,Female ,medicine.symptom ,Child ,Mean length of utterance ,Psychology ,Utterance ,media_common - Abstract
Two important determinants of variation in stuttering frequency are utterance rate and the linguistic properties of the words being spoken. Little is known how these determinants interrelate. It is hypothesized that those linguistic factors that lead to change in word duration, alter utterance rate locally within an utterance that then gives rise to an increase in stuttering frequency. According to the hypothesis, utterance rate variation should occur locally within the linguistic segments in an utterance that is known to increase the likelihood of stuttering. The hypothesis is tested using length of tone unit as the linguistic factor. Three predictions are confirmed: Utterance rate varies locally within the tone units and this local variation affects stuttering frequency; stuttering frequency is positively related to the length of tone units; variations in utterance rate are correlated with tone unit length. Alternative theoretical formulations of these findings are considered.
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- 1999
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24. Phonological Words and Stuttering on Function Words
- Author
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James Au-Yeung, Peter Howell, and Lesley Pilgrim
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Male ,Linguistics and Language ,medicine.medical_specialty ,Vocabulary ,Stuttering ,media_common.quotation_subject ,Audiology ,Article ,Language and Linguistics ,Speech and Hearing ,Speech Production Measurement ,Phonetics ,Communication disorder ,medicine ,Humans ,Language disorder ,Child ,media_common ,Phonology ,medicine.disease ,Linguistics ,El Niño ,Child, Preschool ,Female ,medicine.symptom ,Psychology ,Word (group theory) - Abstract
Stuttering on function words was examined in 51 people who stutter. The people who stutter were subdivided into young (2 to 6 years), middle (6 to 9 years), and older (9 to 12 years) child groups; teenagers (13 to 18 years); and adults (20 to 40 years). As reported by previous researchers, children up to about age 9 stuttered more on function words (pronouns, articles, prepositions, conjunctions, auxiliary verbs), whereas older people tended to stutter more on content words (nouns, main verbs, adverbs, adjectives). Function words in early positions in utterances, again as reported elsewhere, were more likely to be stuttered than function words at later positions in an utterance. This was most apparent for the younger groups of speakers. For the remaining analyses, utterances were segmented into phonological words on the basis of Selkirk’s work (1984). Stuttering rate was higher when function words occurred in early phonological word positions than other phonological word positions whether the phonological word appeared in initial position in an utterance or not. Stuttering rate was highly dependent on whether the function word occurred before or after the single content word allowed in Selkirk’s (1984) phonological words. This applied, once again, whether the phonological word was utterance-initial or not. It is argued that stuttering of function words before their content word in phonological words in young speakers is used as a delaying tactic when the forthcoming content word is not prepared for articulation.
- Published
- 1998
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25. Lexical and syntactic context and stuttering
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James Au-Yeung and Peter Howell
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Linguistics and Language ,Speech production ,Stuttering ,media_common.quotation_subject ,Context (language use) ,Language and Linguistics ,Linguistics ,Lexical item ,Psycholinguistics ,Speech and Hearing ,Fluency ,medicine ,Conversation ,medicine.symptom ,Psychology ,media_common - Abstract
Research on stuttering has concentrated on explaining dysfluencies by factors that are inherent to words, such as their semantic content or phonological characteristics. This has allowed speech to be analysed irrespective of the context in which it occurs. Research on fluent speakers has shown that conversational context affects whether speech is produced fluently or not. These studies have shown that the lexical items and syntactic structures (that other speakers engaged in conversation use) influence the fluency of speakers. In addition, fluent speech is disrupted when planning for forthcoming words and syntactic structures is taking place. In this article it is argued that such word-external factors could potentially also be triggers which lead to words being stuttered.
- Published
- 1998
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26. Detection of supralexical dysfluencies in a text read by children who stutter
- Author
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Kazan Glenn, James Au-Yeung, Peter Howell, Lena Rustin, and Stevie Sackin
- Subjects
Linguistics and Language ,Parsing ,Phrase ,Stuttering ,Cognitive Neuroscience ,Experimental and Cognitive Psychology ,LPN and LVN ,computer.software_genre ,medicine.disease ,Language and Linguistics ,Lexical item ,Linguistics ,Speech and Hearing ,Categorization ,Communication disorder ,medicine ,Language disorder ,medicine.symptom ,Psychology ,computer ,Word (group theory) - Abstract
When asked to read a text, people who stutter produce dysfluencies that can be divided into two types. These are (a) those dysfluencies that mainly influence production of individual lexical items and (b) those involving, either alone or in combination, omitting words, inserting incorrect words and repeating phrases. In case (a), the speech breakdowns are termed lexical dysfluencies (LD). LD include word and part-word repetitions, prolongations, and broken words. The dysfluencies in (b) are termed supralexical (SD). This class comprises interjections, revisions, incomplete phrases, and phrase repetitions. If SD and LD are not distinguished, then the way certain dysfluent words should be categorized is inherently ambiguous. For instance, there is no a priori way of deciding how to categorize an LD that occurs within a group of words comprising an SD. The proposed solution to this problem involves locating and processing SD before LD. Doing this allows any LD that occurs within a group of words that can also be designated as an SD to be assessed and removed from further consideration prior to location of isolated LD (the LD that occur within an SD are, then, subordinate to the SD). A computer-based parser that locates SD in transcriptions of read text is described. Its performance is compared with that of human judges.
- Published
- 1997
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27. Hepatic and splenic scintigraphy in idiopathic systemic amyloidosis
- Author
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Rao, Bhaskara K., Padmalatha, C., Buchon, James Au, and Lieberman, Lionel M.
- Published
- 1981
- Full Text
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28. Syntactic determinants of stuttering in the spontaneous speech of normally fluent and stuttering children
- Author
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Peter Howell and James Au-Yeung
- Subjects
Linguistics and Language ,medicine.medical_specialty ,Stuttering ,Phrase ,Cognitive Neuroscience ,Experimental and Cognitive Psychology ,Audiology ,LPN and LVN ,medicine.disease ,Syntax ,Language and Linguistics ,Developmental psychology ,Speech and Hearing ,Age groups ,Communication disorder ,medicine ,Language disorder ,medicine.symptom ,Psychology ,Sentence ,Spontaneous speech - Abstract
Conflicting findings have been reported concerning whether fluent children use more complex syntactic structures than stutterers and whether or not stutterers experience specific difficulty with complex syntactic structures. On critical examination, the first of these apparent discrepancies appears to be due to (a) differences in the methods employed for syntactic analysis in different studies, and (b) misleading impressions gained by looking at speakers within a single age range. Data were reanalyzed where one method of analysis had shown that fluent speakers and stutterers did not differ with regard to syntactic structures used but where they did show a propensity for stuttering to occur on complex syntactic structures. These data cover a range of age groups. When the second method of syntactic analysis was applied, a difference was found between fluent speakers and stutterers, with the stutterers initially using more simple structures and fewer complex ones. This difference decreased over age groups. However, a difference still remained with respect to which syntactic structures stutterers experience difficulty. An additional analysis, not formerly conducted on these data, showed that, as reported elsewhere, there was a higher probability of stuttering on clause-initial and. It was also shown that this tendency decreased with age group of the stutterers.
- Published
- 1995
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29. The association between stuttering, Brown's factors, and phonological categories in child stutterers ranging in age between 2 and 12 years
- Author
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Peter Howell and James Au-Yeung
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Linguistics and Language ,Stuttering ,Phrase ,Cognitive Neuroscience ,Experimental and Cognitive Psychology ,Phonology ,LPN and LVN ,medicine.disease ,Syntax ,Language and Linguistics ,Developmental psychology ,Speech and Hearing ,Communication disorder ,medicine ,Language disorder ,medicine.symptom ,Association (psychology) ,Psychology ,Sentence - Abstract
Though the phonological difficulty of a word might reasonably be supposed to influence whether a word is stuttered, it has recently been reported that the incidence of stuttering does not depend on this factor in child stutterers. This conclusion is reexamined in the current report. Data are employed that were obtained from groups of child stutterers (and their controls) who vary in age and severity of their disorder. First, it is shown that the measure of phonological difficulty reveals differences in phonological ability for children of different ages (stutterers and fluent controls). The properties of words with regard to whether they are function words or content words, their position in the sentence, their length, and the phoneme that they start with vary between phonological categories (referred to as “Brown's factors”). Since these factors could influence whether words are stuttered in their own right, they may led to apparent differences in stuttering between words in different phonological categories that are spurious. Alternatively, these factors may disguise influences that phonological categories have on stuttering. It is shown in the next analysis that the words in the various phonological categories differ with regard to Brown's factors. In the final analysis, the proportion of words stuttered for words in each phonological category are analyzed so that any influence Brown's factors might have are removed by treating the factors as covariates. No dependence of stuttering on phonological category is observed for age group, stutterer's severity, or word types (stuttered word or word following the stuttered word). Thus, phonological difficulty as measured here and elsewhere does not appear to be a major factor governing the incidence of stuttering in children.
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- 1995
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30. Abstracts
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W. A. C. Mutch, I. W. C. White, N. Donen, I. R. Thomson, M. Rosenbloom, M. Cheang, M. West, Greg Bryson, Christina Mundi, Jean-Yves Dupuis, Michael Bourke, Paul McDonagh, Michael Curran, John Kitts, J. Earl Wynands, Alison S. Carr, Elizabeth J. Hartley, Helen M. Holtby, Peter Cox, Bruce A. Macpherson, James E. Baker, Andrew J. Baker, C. David Mazer, C. Peniston, T. David, D. C. H. Cheng, J. Karski, B. Asokumar, J. Carroll, H. Nierenberg, S. Roger, A. N. Sandier, J. Tong, C. M. Feindel, J. F. Boylan, S. J. Teasdale, J. Boylan, P. Harley, Jennifer E. Froelich, David P. Archer, Alastair Ewen, Naaznin Samanani, Sheldon H. Roth, Richard I. Hall, Michael Neumeister, Gwen Dawe, Cathy Cody, Randy O’Brien, Jan Shields-Thomson, Kenneth M. LeDez, Catherine Penney, Walter Snedden, John Tucker, Nicolas Fauvel, Mladen Glavinovic, François Donati, S. B. Backman, R. D. Stein, C. Polosa, C. Abdallah, S. Gal, A. John Clark, George A. Doig, Tunde Gondocz, E. A. Peter, A. Lopez, A. Mathieu, Pierre Couture, Daniel Boudreault, Marc Derouin, Martin Allard, Gilbert Blaise, Dominique Girard, Richard L. Knill, Teresa Novick, Margaret K. Vandervoort, Frances Chung, Shantha Paramanathar, Smita Parikh, Charles Cruise, Christina Michaloliakou, Brenda Dusek, D. K. Rose, M. M. Cohen, D. DeBoer, George Shorten, Earnest Cutz, Jerrold Lerman, Myrna Dolovich, Edward T. Crosby, Robert Cirone, Dennis Reid, Joanne Lind, Melanie Armstrong, Wanda Doyle, S. Halpern, P. Glanc, T. Myhr, M -L. Ryan, K. Fong, K. Amankwah, A. Ohlsson, R. Preston, Andor Petras, Michael J. Jacka, Brian Milne, Kanji Nakatsu, S. Pancham, Graeme Smith, Kush N. Duggal, M. Joanne Douglas, Pamela M. Merrick, Philip Blew, Donald Miller, Raymond Martineau, Kathryn Hull, C. M. Baron, S. Kowalskl, R. Greengrass, T. Horan, H. Unruh, C. L. Baron, Patricia M. Cruchley, K. Nakajima, Y. Sugiura, Y. Goto, K. Takakura, J. Harada, Robert M. K. W. Lee, Angelica M. Fargas-Babjak, Jin Ni, Eva S. Werstiuk, Joseph Woo, David H. Morison, Michael D. McHugh, Hanna M. Pappius, Hironori Ishihara, Yuki Shimodate, Hiroaki Koh, Akitomo Matsuki, John W. R. Mclntyre, Pierre Bergeron, Lulz G. R. DeLima, Jean-Yves Dupuls, James Enns, J. M. Murkin, F. N. McKenzie, S. White, N. A. Shannon, Wojciech B. Dobkowski, Judy L. Kutt, Bernard J. Mezon, David R. Grant, William J. Wall, Dennis D. Doblar, Yong C. Lim, Luc Frenette, Jaime R. Ronderos, Steve Poplawski, Dinesh Ranjan, L. Dubé, L. Van Obbergh, M. Francoeur, C. Blouin, R. Carrier, D. Doblar, J. Ronderos, D. Singer, J. Cox, B. Gosdin, M. Boatwright, Charles E. Smith, Aleksandr Rovner, Carlos Botero, Curt Holbrook, Nileshkumar Patel, Alfred Pinchak, Alfred C. Pinchak, Yin James Kao, Andrew Thio, Steven J. Barker, Patrick Sullivan, Matthew Posner, C. William Cole, Patty Lindsay, Paul B. Langevin, Paul A. Gulig, N. Gravenstein, David T. Wong, Manuel Gomez, Glenn P. McGuire, Robert J. Byrick, Shared K. Sharma, Frederick J. Carmicheal, Walter J. Montanera, Sharad Sharma, D. A. Yee, Basem I. Naser, G. L. Bryson, J. B. Kitts, D. R. Miller, R. J. Martineau, M. J. Curran, P. R. Bragg, Jacek M. Karski, Davy Cheng, Kevin Bailey, S. Levytam, R. Arellano, J. Katz, J. Doyle, Mitchel B. Sosis, William Blazek, G. Plourde, A. Malik, Tammy Peddle, James Au, Jeffrey Sloan, Mark Cleland, Donald E. Hancock, Nilesh Patel, Frank Costello, Louise Patterson, Masao Yamashita, Tsukasa Kondo, M. R. Graham, D. Thiessen, David F. Vener, Thomas Long, S. Marion, D. J. Steward, Berton Braverman, Mark Levine, Steve Yentis, Catherine R. Bachman, Murray Kopelow, Ann McNeill, R. Graham, Norbert Froese, Leena Patel, Heinz Reimer, Jo Swartz, Suzanne Ullyot, Harley Wong, Maria A. Markakis, Nancy Siklch, Blair D. Goranson, Scott A. Lang, Martin J. Stockwell, Bibiana Cujec, Raymond W. Yip, Lucy C. Southeriand, Tanya Duke B. Vet, Jeisane M. Gollagher, Lesley-Ann Crone, James G. Ferguson, Demetrius Litwin, Maria Bertlik, Beverley A. Orser, Lu-Wang Yang, John F. MacDonald, Gary F. Morris, Wendy L. Gore-Hickman, J. E. Zamora, O. P. Rosaeg, M. P. Lindsay, M. L. Crossan, Carol Pattee, Michael Adams, John P. Koller, Guy J. Lavoie, Wynn M. Rigal, Dylan A. Taylor, Michael G. Grace, Barry A. Flnegan, Christopher Hawkes, Harry Hopkins, Michael Tierney, David R. Drover, Gordon Whatley, J. W. Donald Knox, Jarmila Rausa, Hossam El-Beheiry, Ronald Seegobin, Georgia C. Hirst, William N. Dust, J. David Cassidy, D. Boisvert, H. Braden, M. L. Halperin, S. Cheema-Dhadli, D. J. McKnight, W. Singer, Thomas Elwood, Shirley Huchcroft, Charles MacAdams, R. Peter Farran, Gerald Goresky, Phillip LaLande, Gilles Lacroix, Martin Lessard, Claude Trépanier, Janet M. van Vlymen, Joel L. Parlow, Chikwendu Ibebunjo, Arnold H. Morscher, Gregory J. Gordon, H. P. Grocott, Susan E. Belo, Georgios Koutsoukos, Susan Belo, David Smith, Sarah Henderson, Adriene Gelb, G. Kantor, N. H. Badner, W. E. Komar, R. Bhandari, D. Cuillerier, W. Dobkowski, M. H. Smith, A. N. Vannelli, Sean Wharton, Mike Tierney, E. Redmond, E. Reddy, A. Gray, J. Flynn, R. B. Bourne, C. H. Rorabeck, S. J. MacDonald, J. A. Doyle, Peter T. Newton, Carol A. Moote, R. Joiner, M. F. X. Glynn, Vytas Zulys, M. Hennessy, T. Winton, W. Demajo, William P. S. McKay, Peter H. Gregson, Benjamin W. S. McKay, Julio Militzer, Eric Hollebone, Raymond Yee, George Klein, R. L. Garnett, J. Conway, F. E. Ralley, G. R. Robbins, James E. Brown, J. V. Frei, Edward Podufal, Norman J. Snow, Altagracia M. Chavez, Richard P. Kramer, D. Mickle, William A. Tweed, Bisharad M. Shrestha, Narendra B. Basnyat, Bhawan D. Lekhak, Susan D. O’Leary, J. K. Maryniak, John H. Tucker, Cameron B. Guest, J. Brendan Mullen, J. Colin Kay, Dan F. Wigglesworth, Mashallah Goodarzi, Nicte Ha Shier, John A. Ogden, O. R. Hung, S. Pytka, M. F. Murphy, B. Martin, and R. D. Stewart
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Anesthesiology and Pain Medicine ,General Medicine - Published
- 1994
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31. Stuttering on function and content words across age groups of German speakers who stutter
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Dieter Rommel, James Au-Yeung, Peter Howell, and Katharina Dworzynski
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Stuttering ,Phonological word ,Content word ,Linguistics ,language.human_language ,Article ,German ,Noun ,Function word ,language ,medicine ,medicine.symptom ,Psychology ,Content (Freudian dream analysis) ,Word (group theory) - Abstract
Recent research into stuttering in English has shown that function word disfluency decreases with age whereas content words disfluency increases. Also function words that precede a content word are significantly more likely to be stuttered than those that follow content words (Au-Yeung, Howell and Pilgrim, 1998; Howell, Au-Yeung and Sackin, 1999). These studies have used the concept of the phonological word as a means of investigating these phenomena. Phonological words help to determine the position of function words relative to content words and to establish the origin of the patterns of disfluency with respect to these two word classes. The current investigation analysed German speech for similar patterns. German contains many long compound nouns; on this basis, German content words are more complex than English ones. Thus, the patterns of disfluency within phonological words may differ between German and English. Results indicated three main findings. Function words that occupy an early position in a PW have higher rates of disfluency than those that occur later in a PW, this being most apparent for the youngest speakers. Second, function words that precede the content word in a PW have higher rates of disfluency than those that follow the content word. Third, young speakers exhibit high rates of disfluency on function words, but this drops off with age and, correspondingly, disfluency rate on content words increases. The patterns within phonological words may be general to German and English and can be accounted for by the EXPLAN model, assuming lexical class operates equivalently across these languages or that lexical categories contain some common characteristic that is associated with fluency across the languages.
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- 2008
32. INTERNAL STRUCTURE OF CONTENT WORDS LEADING TO LIFESPAN DIFFERENCES IN PHONOLOGICAL DIFFICULTY IN STUTTERING
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Stevie Sackin, Peter Howell, and James Au-Yeung
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Consonant ,Linguistics and Language ,Stuttering ,Cognitive Neuroscience ,Experimental and Cognitive Psychology ,Phonology ,LPN and LVN ,medicine.disease ,Part of speech ,Language and Linguistics ,Developmental psychology ,Speech and Hearing ,Language development ,Communication disorder ,medicine ,Language disorder ,medicine.symptom ,Psychology ,Word (group theory) - Abstract
This study investigated whether frequency of stuttering was affected by factors that specify the phonological difficulty of a sound and whether and how any influences vary across age groups. Analyses were performed separately on content words and function words. The phonological factors examined were: a) Whether the word contained a late emerging consonant (LEC); and b) Whether the word contained a consonant string (CS). Analyses showed that these factors occurred at different rates across the age groups used (children under 12, teenagers between 12 and 18, and adults). A more detailed breakdown was also reported of frequency of usage of LEC and CS over age groups depending on whether and where these factors occurred in the content words; all nine combinations of no LEC, word-initial LEC, non-initial LEC with no CS, word-initial CS, and non-initial CS were examined. Usage of certain of these nine categories varied over age groups. Friedman statistic on the ratio of stuttering (proportion of stuttered words in a particular word class divided by the proportion of words in that particular word class) showed that the frequency of stuttering remained high for adult speakers when CS and LEC both occurred in a word and when they appeared in word-initial position. These findings support a recently proposed theory that accounts for life-span changes in stuttering.
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- 2008
33. Exchange of disfluency with age from function words to content words in spanish speakers who stutter
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Isabel Vallejo Gomez, James Au-Yeung, and Peter Howell
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Adult ,Male ,Linguistics and Language ,Vocabulary ,Stuttering ,Adolescent ,media_common.quotation_subject ,Developmental change ,Language and Linguistics ,Article ,Developmental psychology ,Speech and Hearing ,Speech Production Measurement ,Communication disorder ,Phonetics ,medicine ,Humans ,Language disorder ,Content (Freudian dream analysis) ,Child ,media_common ,Aged ,Language ,Age Factors ,Middle Aged ,medicine.disease ,Linguistics ,Spain ,Child, Preschool ,Female ,medicine.symptom ,Psychology ,Word (group theory) - Abstract
The main purpose of the present study was to examine whether the developmental change in loci of disfluency from mainly function words to mainly content words, observed for English speakers who stutter (P. Howell, J. Au-Yeung, & S. Sackin, 1999), also occurs for comparable Spanish speakers who stutter. The participants were divided into 5 age groups. There were 7 participants in Group 1, from 3 to 5 years old; 11 in Group 2, from 6 to 9 years old; 10 in Group 3, from 10 to 11 years old; 9 in Group 4, from 12 to 16 years old; and 9 in Group 5, from 20 to 68 years old. Across all groups, 36 of the 46 participants were male. The study method involved segmenting speech into phonological words (PWs) that consist of an obligatory content word with optional function words that precede and follow it. The initial function words in the PWs were examined to establish whether they have a higher disfluency rate than the final ones (J. Au-Yeung, P. Howell, & L. Pilgrim, 1998). Disfluency on function words in a PW was higher when the word occurred before a content word rather than after a content word for all age groups. Disfluencies on function and content words were then examined to determine whether they change over age groups in the same way as for English speakers who stutter (Howell et al., 1999). The rate of disfluency on function words was higher than that on content words, particularly in the youngest speakers. Function word disfluency rate dropped off and content word disfluency rate increased across age groups. These patterns are similar to those reported for English. Possible explanations for these similarities across the two languages are discussed.
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- 2003
34. Toward automatic extraction of video objects
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Ze-Nian Li and James Au
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Motion compensation ,Computer science ,business.industry ,Locale (computer hardware) ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Quarter-pixel motion ,Match moving ,Feature (computer vision) ,Motion estimation ,Video tracking ,Computer Science::Multimedia ,Computer vision ,Artificial intelligence ,business ,Block-matching algorithm - Abstract
A new technique based on feature localization is developed for segmenting and tracking objects in videos. A video locale is a sequence of image feature locales that share similar features (color, texture, shape, and motion) in the spatio-temporal domain of videos. To exploit the temporal redundancy in digital videos, two algorithms (intra-frame and inter-frame) are used to grow locales efficiently. Multiple motion tracking is achieved by tracking and performing tile-based dominant motion estimation for each locale separately. Hence, the difficulty of multiple non-dominating motions is avoided. Tests on natural videos have shown very good results.
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- 2002
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35. The EXPLAN theory of fluency control applied to the diagnosis of stuttering
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Peter Howell and James Au-Yeung
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- 2002
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36. Exchange of Stuttering From Function Words to Content Words With Age
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James Au-Yeung, Stevie Sackin, and Peter Howell
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Male ,Linguistics and Language ,Vocabulary ,Stuttering ,Adolescent ,media_common.quotation_subject ,Language and Linguistics ,Article ,Speech and Hearing ,Communication disorder ,Phonetics ,medicine ,Humans ,Language disorder ,Content (Freudian dream analysis) ,Child ,media_common ,Age Factors ,Phonology ,medicine.disease ,Linguistics ,Child, Preschool ,Female ,medicine.symptom ,Psychology ,Word (group theory) ,Cognitive psychology - Abstract
Dysfluencies on function words in the speech of people who stutter mainly occur when function words precede, rather than follow, content words (Au-Yeung, Howell, & Pilgrim, 1998). It is hypothesized that such function word dysfluencies occur when the plan for the subsequent content word is not ready for execution. Repetition and hesitation on the function words buys time to complete the plan for the content word. Stuttering arises when speakers abandon the use of this delaying strategy and carry on, attempting production of the subsequent, partly prepared content word. To test these hypotheses, the relationship between dysfluency on function and content words was investigated in the spontaneous speech of 51 people who stutter and 68 people who do not stutter. These participants were subdivided into the following age groups: 2–6-year-olds, 7–9-year-olds, 10–12-year-olds, teenagers (13–18 years), and adults (20–40 years). Very few dysfluencies occurred for either fluency group on function words that occupied a position after a content word. For both fluency groups, dysfluency within each phonological word occurred predominantly on either the function word preceding the content word or on the content word itself, but not both. Fluent speakers had a higher percentage of dysfluency on initial function words than content words. Whether dysfluency occurred on initial function words or content words changed over age groups for speakers who stutter. For the 2–6-year-old speakers that stutter, there was a higher percentage of dysfluencies on initial function words than content words. In subsequent age groups, dysfluency decreased on function words and increased on content words. These data are interpreted as suggesting that fluent speakers use repetition of function words to delay production of the subsequent content words, whereas people who stutter carry on and attempt a content word on the basis of an incomplete plan.
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- 1999
37. T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study
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Adrienn Angyal, PhD, Stephanie Longet, PhD, Shona C Moore, PhD, Rebecca P Payne, DPhil, Adam Harding, MSc, Tom Tipton, PhD, Patpong Rongkard, MSc, Mohammad Ali, MD, Luisa M Hering, MSc, Naomi Meardon, MBChB, James Austin, PhD, Rebecca Brown, PhD, Donal Skelly, PhD, Natalie Gillson, BSc, Sue L Dobson, MSc, Andrew Cross, PhD, Gurjinder Sandhar, MSc, Jonathan A Kilby, MSc, Jessica K Tyerman, BSc, Alexander R Nicols, MSc, Jarmila S Spegarova, PhD, Hema Mehta, DPhil, Hailey Hornsby, MSc, Rachel Whitham, MSc, Christopher P Conlon, ProfPhD, Katie Jeffery, PhD, Philip Goulder, ProfDPhil, John Frater, ProfPhD, Christina Dold, PhD, Matthew Pace, PhD, Ane Ogbe, PhD, Helen Brown, BSc, M Azim Ansari, DPhil, Emily Adland, PhD, Anthony Brown, BSc, Meera Chand, FRCPath, Adrian Shields, PhD, Philippa C Matthews, PhD, Susan Hopkins, PhD, Victoria Hall, PhD, William James, ProfDPhil, Sarah L Rowland-Jones, ProfDM, Paul Klenerman, ProfPhD, Susanna Dunachie, ProfPhD, Alex Richter, ProfPhD, Christopher J A Duncan, DPhil, Eleanor Barnes, ProfPhD, Miles Carroll, ProfPhD, Lance Turtle, PhD, Thushan I de Silva, PhD, Adam Harding, Adam Watson, Adrian Shields, Adrienn Angyal, Ahmed Alhussni, Alex Richter, Alexander Nicols, Alexandra Deeks, Alice Webb-Bridges, Andrew Cross, Ane Ogbe, Anni Jämsén, Anthony Brown, Anu Chawla, Christina Dold, Christopher Duncan, Christopher Conlon, Donal Skelly, Denise O'Donnell, Eleanor Barnes, Emily Adland, Esme Weeks, Gurjinder Sandhar, Hailey Hornsby, Helen Brown, Hema Mehta, Hibatullah Abuelgasim, Huiyuan Xiao, James Austin, Jarmila Spegarova, Jennifer Holmes, Jenny Haworth, Jessica Tyerman, John Frater, Jonathan Kilby, Joseph Cutteridge, Katie Jeffery, Katy Lillie, Lance Turtle, Leigh Romaniuk, Lucy Denly, Luisa Hering, M. Azim Ansari, Matthew Pace, Meera Chand, Miles Carroll, Mohammad Ali, Mwila Kasanyinga, Naomi Meardon, Natalie Gillson, Patpong Rongkard, Paul Klenerman, Philip Goulder, Philippa Matthews, Rachel Whitham, Rebecca Brown, Rebecca Payne, Robert Wilson, Sarah Rowland-Jones, Sarah Thomas, Shona Moore, Siobhan Gardiner, Stephanie Longet, Stephanie Tucker, Sue Dobson, Susan Hopkins, Susanna Dunachie, Syed Adlou, Thushan de Silva, Tom Tipton, Victoria Hall, William James, Allan Lawrie, Nikki Smith, Helena Turton, Amira Zawia, Martin Bayley, Alex Fairman, Kate Harrington, Rosemary Kirk, Louise Marsh, Lisa Watson, Steven Wood, Benjamin Diffey, Chris Jones, Lauren Lett, Gareth Platt, Krishanthi Subramaniam, Daniel Wootton, Brendan Payne, Sophie Hambleton, Sinead Kelly, Judith Marston, Sonia Poolan, Dianne Turner, Muzlifah Haniffa, Emily Stephenson, Sandra Adele, Hossain Delowar Akhter, Senthil Chinnakannan, Catherine de Lara, Timothy Donnison, Carl-Philipp Hackstein, Lian Lee, Nicholas Lim, Tom Malone, Eloise Phillips, Narayan Ramamurthy, Nichola Robinson, Oliver Sampson, David Eyre, Beatrice Simmons, Lizzie Stafford, Alexander Mentzer, Ali Amini, Carolina Arancibia-Cárcamo, Nicholas Provine, Simon Travis, Stavros Dimitriadis, Sile Johnson, Sarah Foulkes, Jameel Khawam, Edgar Wellington, Javier Gilbert-Jaramillo, Michael Knight, Maeva Dupont, Emily Horner, James Thaventhiran, and Jeremy Chalk
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Medicine (General) ,R5-920 ,Microbiology ,QR1-502 - Abstract
Summary: Background: Previous infection with SARS-CoV-2 affects the immune response to the first dose of the SARS-CoV-2 vaccine. We aimed to compare SARS-CoV-2-specific T-cell and antibody responses in health-care workers with and without previous SARS-CoV-2 infection following a single dose of the BNT162b2 (tozinameran; Pfizer–BioNTech) mRNA vaccine. Methods: We sampled health-care workers enrolled in the PITCH study across four hospital sites in the UK (Oxford, Liverpool, Newcastle, and Sheffield). All health-care workers aged 18 years or older consenting to participate in this prospective cohort study were included, with no exclusion criteria applied. Blood samples were collected where possible before vaccination and 28 (±7) days following one or two doses (given 3–4 weeks apart) of the BNT162b2 vaccine. Previous infection was determined by a documented SARS-CoV-2-positive RT-PCR result or the presence of positive anti-SARS-CoV-2 nucleocapsid antibodies. We measured spike-specific IgG antibodies and quantified T-cell responses by interferon-γ enzyme-linked immunospot assay in all participants where samples were available at the time of analysis, comparing SARS-CoV-2-naive individuals to those with previous infection. Findings: Between Dec 9, 2020, and Feb 9, 2021, 119 SARS-CoV-2-naive and 145 previously infected health-care workers received one dose, and 25 SARS-CoV-2-naive health-care workers received two doses, of the BNT162b2 vaccine. In previously infected health-care workers, the median time from previous infection to vaccination was 268 days (IQR 232–285). At 28 days (IQR 27–33) after a single dose, the spike-specific T-cell response measured in fresh peripheral blood mononuclear cells (PBMCs) was higher in previously infected (n=76) than in infection-naive (n=45) health-care workers (median 284 [IQR 150–461] vs 55 [IQR 24–132] spot-forming units [SFUs] per 106 PBMCs; p
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- 2022
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38. Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation
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James Auta, Andrea Locci, Alessandro Guidotti, John M. Davis, and Hongxin Dong
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GABA ,Diazepam ,Alzheimer's ,Epigenetics ,Behavior ,Hippocampus ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Conflicting evidence suggest that perturbations of GABAergic neurotransmission play crucial roles in disrupting cortical neuronal network oscillations, memory, and cognitive deficits in Alzheimer's disease (AD). However, the role and impact of sex differences on GABAergic transmission in AD are not well understood. Using an APP knock-in mouse model of AD, APPNLGF mice, we studied the effects of acute diazepam administration on memory and anxiety-like behavior to unveil sex-dependent dysregulation of GABAergic neurotransmission. We also examined sex differences in GABAA receptor subunit mRNA and protein expression and the role of epigenetic regulation in hippocampus of APPNLGF mice. We found that diazepam elicited dose-dependent suppression of locomotion in wildtype and APPNLGF mice. However, a low dose, which had no significant effect in both male and female wildtype as well as female APPNLGF mice, significantly suppressed locomotion in male APPNLGF mice. Furthermore, this low dose of diazepam was more efficacious at eliciting anxiolytic-like effects in male than female APPNLGF mice. The same low dose of diazepam disrupted recognition memory exclusively in male APPNLGF mice. Biochemical analyses revealed that hippocampal α1 and α5 GABAA receptor subunits mRNA and protein expression were significantly higher in male than female APPNLGF mice and were regulated by histone H3 tri-methylation (H3K4me3) but not histone H3 acetylation. The higher sensitivity of APPNLGF males to diazepam-induced behavioral effects may potentially be due to epigenetic-dependent upregulation of hippocampal α1 and α5 GABAA receptor subunits expression compared to female APPNLGF mice. These findings suggest that dysregulation of GABAergic neurotransmission plays a significant role in memory and affective behavior, particularly in male APPNLGF mice.
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- 2022
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39. Gene expression of methylation cycle and related genes in lymphocytes and brain of patients with schizophrenia and non-psychotic controls
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Henry Sershen, Alessandro Guidotti, James Auta, Jenny Drnevich, Dennis R. Grayson, Marin Veldic, Jordan Meyers, Mary Youseff, Adrian Zhubi, Keturah Faurot, Renrong Wu, Jingping Zhao, Hua Jin, Abel Lajtha, John M. Davis, and Robert C. Smith
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Schizophrenia ,mRNA biomarkers ,Lymphocyte vs brain ,Epigenetics ,DNMTs ,GABAergic ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Some of the biochemical abnormalities underlying schizophrenia, involve differences in methylation and methylating enzymes, as well as other related target genes. We present results of a study of differences in mRNA expression in peripheral blood lymphocytes (PBLs) and post-mortem brains of chronic schizophrenics (CSZ) and non-psychotic controls (NPC), emphasizing the differential effects of sex and antipsychotic drug treatment on mRNA findings. We studied mRNA expression in lymphocytes of 61 CSZ and 49 NPC subjects using qPCR assays with TaqMan probes to assess levels of DNMT, TET, GABAergic, NR3C1, BDNF mRNAs, and several additional targets identified in a recent RNA sequence analysis. In parallel we studied DNMT1 and GAD67 in samples of brain tissues from 19 CSZ, 26 NPC. In PBLs DNMT1 and DNMT3A mRNA levels were significantly higher in male CSZ vs NPC No significant differences were detected in females. The GAD1, NR3C1 and CNTNAP2 mRNA levels were significantly higher in CSZ than NPC. In CSZ patients treated with clozapine, GAD-1 related, CNTNAP2, and IMPA2 mRNAs were significantly higher than in CSZ subjects not treated with clozapine. Differences between CSZ vs NPC in these mRNAs was primarily attributable to the clozapine treatment. In the brain samples, DNMT1 was significantly higher and GAD67 was significantly lower in CSZ than in NPC, but there were no significant sex differences in diagnostic effects. These findings highlight the importance of considering sex and drug treatment effects in assessing the substantive significance of differences in mRNAs between CSZ and NPC.
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- 2021
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40. Knowledge and attitudes of future physicians in the Cordillera region of the Philippines towards climate change: A pre-pandemic cross-sectional study
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John Anthony A. Domantay, Carl Froilan D. Leochico, Philline Aurea Grace S. Salvador, Verna Moila Ciriaco, Patrick Raymond Abad, Von Eagan Capistrano, Gino Miguel Cruz, Louie Christopher Darang, Dennis Myles Del Rosario, James Austin Gadgad, Jason Pagalanan, Adrian Palaylay, Froi Jovanni Perez, and Christian Philip Torres
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Climate change ,Sustainability ,Medical students ,Survey ,Social responsiveness ,Public aspects of medicine ,RA1-1270 ,Meteorology. Climatology ,QC851-999 - Abstract
Background: It remains unknown what students from medical schools in the Philippines, such as the School of Medicine at Saint Louis University in the Cordilleras, know and feel about climate change, an important issue in this ecological region of the country. Objective: To determine the knowledge and attitudes of future physicians towards climate change. Methods: Pre-pandemic, we conducted a paper survey among first and second year medical students, adapting questionnaires from previous studies: (1) Americans’ Knowledge of Climate Change by the Yale Project on Climate Change Communication; and (2) Attitudes about Global Warming based on the 4th Assessment Report of the United Nations Intergovernmental Panel on Climate Change. A pretest was done to ensure respondents’ understanding of the questions. Sample size was computed at 176, and random sampling was done. Results: We obtained a 100% response rate. The respondents were mostly females, 0.05). Conclusion: The respondents generally showed favorable attitudes towards climate change, although their knowledge on the topic could still be improved. Our study may serve as a basis for developing strategies towards a socially responsive medical education within the Philippines.
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- 2021
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41. ORTHOPEDIC ASSESSMENT OF THE HIPS IN NEWBORNS AFTER INITIAL PEDIATRIC SURVEY
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Felipe Chioro Gonzalez, Felipe Fontes, Guilherme de Albuquerque Souza Maia, James Augusto Soares Ferro, David Leite Fortes, and Daniel Mendes Leal
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Hip Dislocation Congenital ,Hip Dislocation ,Infant newborns ,Medicine ,Orthopedic surgery ,RD701-811 - Abstract
ABSTRACT Objective: To analyze and follow-up patients previously selected by pediatricians at the time of birth who presented altered initial physical examination results to identify the pathological changes in their hips. Methods: A prospective cohort study was conducted involving 34 newborns (68 hips) out of a total of 1273 live births; these infants were assessed within the first days of life as altered findings were noted in the initial examination by the pediatrician. The results of clinical and ultrasonographic examination performed using the GRAF method and of specific treatments were analyzed. Results: Of the 68 hips in 34 patients, 2 hips in 2 patients required intervention using the Pavlik harness for 8 weeks; a satisfactory treatment outcome was obtained in both cases. Conclusions: Despite the low orthopedic workload in medical courses, it was possible to identify data consistent with the literature, both in the presentation of clinical findings and in those that required treatment, indicating that an initial evaluation of all newborns is mandatory, especially those with risk factors. Level of evidence IV, case series.
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- 2019
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42. Circulating histones play a central role in COVID-19-associated coagulopathy and mortality
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Rebecca J. Shaw, Simon T. Abrams, James Austin, Joseph M. Taylor, Steven Lane, Tina Dutt, Colin Downey, Min Du, Lance Turtle, J. Kenneth Baillie, Peter J.M. Openshaw, Guozheng Wang, Malcolm G. Semple, and Cheng-Hock Toh
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2021
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43. Modeling Investment Trends: A Logarithmic-Modified Markov Chain Approach
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Imoh Udo Moffat, James Augustine Ukpabio, and Emmanuel Alphonsus Akpan
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Convergence ,Heteroscdasticity ,Logarithmic transformation ,Markov chain ,Stochastic process ,Transition matrix ,Probabilities. Mathematical statistics ,QA273-280 - Abstract
The study aimed at stabilizing the changing variance using the logarithmic transformation to achieve a significant proportion of stability and a faster rate of convergence of the steady state transition probability in Markov chains. The traditional Markov chain and logarithmic-modified Markov chain were considered. On exploring the yearly data on the stock prices from 2015 to 2018 as obtained from the Nigerian Stock Exchange, it was found that the steady state of logarithmic-modified Markov chain converged faster than the tradition Markov chain with efficiency in tracking the correct cycles where the stock movements are trending irrespective of which cycle it starts at time zero with differences in probability values by 1.1%, 0.7%, −0.41% and −1.37% for accumulation, markup, distribution and mark-down cycles, respectively. Thus, it could be deduced that the logarithmic modification enhances the ability of the Markov chain to tract the variation of the steady state probabilities faster than the traditional counterpart.
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- 2020
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44. Speech behavior of improved and not improved children before treatment
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Stephen Davis, James Au-Yeung, N. Charles, Peter Howell, and Stevie Sackin
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Speech and Hearing ,Linguistics and Language ,medicine.medical_specialty ,Cognitive Neuroscience ,medicine ,Experimental and Cognitive Psychology ,Audiology ,LPN and LVN ,Psychology ,Language and Linguistics - Published
- 2000
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45. Automatic recognition of stuttering
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James Au-Yeung, Stevie Sackin, Kazan Glenn, and Peter Howell
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Speech and Hearing ,Linguistics and Language ,Stuttering ,Cognitive Neuroscience ,medicine ,Experimental and Cognitive Psychology ,medicine.symptom ,LPN and LVN ,Psychology ,Language and Linguistics ,Cognitive psychology - Published
- 1997
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46. Impact of Conventional Water Treatment Coagulants on Mineral Scaling in RO Desalting of Brackish Water.
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Myung-man Kim, James Au, Anditya Rahardianto, Julius Glater, Yoram Cohen, Fredrick W. Gerringer, and Christopher J. Gabelich
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- 2009
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47. The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development
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Zhenxing Cheng, Simon T. Abrams, James Austin, Julien Toh, Susan Siyu Wang, Zhi Wang, Qian Yu, Weiping Yu, Cheng Hock Toh, and Guozheng Wang
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Pathology ,RB1-214 - Abstract
The pathological roles of bacterial DNA have been documented many decades ago. Bacterial DNAs are different from mammalian DNAs; the latter are heavily methylated. Mammalian cells have sensors such as TLR-9 to sense the DNAs with nonmethylated CpGs and distinguish them from host DNAs with methylated CpGs. Further investigation has identified many other types of DNA sensors distributed in a variety of cellular compartments. These sensors not only sense foreign DNAs, including bacterial and viral DNAs, but also sense damaged DNAs from the host cells. The major downstream signalling pathways includeTLR-9-MyD88-IKKa-IRF-7/NF-κB pathways to increase IFN/proinflammatory cytokine production, STING-TBK1-IRF3 pathway to increase IFN-beta, and AIM2-ASC-caspas-1 pathway to release IL-1beta. The major outcome is to activate host immune response by inducing cytokine production. In this review, we focus on the roles and potential mechanisms of DNA sensors and downstream pathways in sepsis. Although bacterial DNAs play important roles in sepsis development, bacterial DNAs alone are unable to cause severe disease nor lead to death. Priming animals with bacterial DNAs facilitate other pathological factors, such as LPS and other virulent factors, to induce severe disease and lethality. We also discuss compartmental distribution of DNA sensors and pathological significance as well as the transport of extracellular DNAs into cells. Understanding the roles of DNA sensors and signal pathways will pave the way for novel therapeutic strategies in many diseases, particularly in sepsis.
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- 2020
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48. Governança em cenários de escassez hídrica
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Fábio Albergaria de Queiroz and James Augusto Pires Tiburcio
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hydrological interdependence ,hydropolitical complexes ,Jordan River Basin ,Southern Africa ,water scarcity ,Political science (General) ,JA1-92 - Abstract
Water is an increasingly scarce resource. One of the most noteworthy discursive features of the last decades has been a growing awareness of water-related issues as a critically important component for regional stability. This situation helps to explain why, in many cases, water management involves political, economic, social, environmental and even military issues. But, in what intensity? This article analyzes the cases of Southern Africa and the Jordan River Basin due to their prevailing condition of water scarcity. In order to verify the role developed by the mechanisms of governance in accommodating the interests of the riparian states, the Hydropolitical Complexes Theory was applied. Inferences demonstrated a trend towards cooperation in Southern Africa that is due to the successful institutionalization of management mechanisms capable of minimizing potential for conflicts. On the other hand, in the Jordan Basin, the struggle to control water resources has been a significant factor in sustaining tension among riparian countries.
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- 2019
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49. O Programa Fome Zero sob Foco
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James Augusto Pires Tiburcio
- Subjects
Environmental sciences ,GE1-350 - Abstract
Aaron Ansell. Zero Hunger: Political Culture and Antipoverty Policy in Northeast Brazil. Chapel Hill, The University of North Carolina Press, 2014. 239 p. Anexos, referências bibliográficas, índice remissivo, ilustrações. ISBN 978-1-46961397-0 .
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- 2015
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50. Storehouse and sanctuary: the role of Brazil in world food security
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James Augusto Pires Tiburcio and Marcel Bursztyn
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Environmental sciences ,GE1-350 ,Science - Abstract
Natural endowments such as land availability, abundant water, fertile soils, and favorable climate combined with decreasing population growth place Brazil as the leading force in world food production. Brazil is also the guardian of the most diverse eco-systems in the planet and is continuously wrestling between the expansion of the agricultural land area and the preservation of the most diverse fauna and flora, embodied in the Amazon forest. Addressing the international political economy of trade and food security from a Brazilian perspective, this paper argues that the main obstacles facing Brazil in food security are not domestic, but international. International political issues are at the core of the most relevant hurdles and understanding the reciprocal relationship between world food security and the emerging economies position especially that of Brazil in food production and trade is crucial. I argue that comprehending the elements that constrain the present and future role of Brazil in fulfilling its potential as food supplier in an ecologically and economically sustainable path, as well as its new found role as agricultural cooperation partner in the promotion of a food safe world is paramount if the world is to feed 7 billion mouths.
- Published
- 2013
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