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7,089 results on '"James, John"'

3. State Space Modelling for detecting and characterising Gravitational Waves afterglows

Author

d'Antonio, Daniele, Bell, Martin Ellis, Brown, James John, and Grazian, Clara

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We propose the usage of an innovative method for selecting transients and variables. These sources are detected at different wavelengths across the electromagnetic spectrum spanning from radio waves to gamma-rays. We focus on radio signals and use State Space Models, which are also referred to as Dynamic Linear Models. State Space Models (and more generally parametric autoregressive models) have been the mainstay of economic modelling for some years, but rarely they have been used in Astrophysics. The statistics currently used to identify radio variables and transients are not sophisticated enough to distinguish different types of variability. These methods simply report the overall modulation and significance of the variability, and the ordering of the data in time is insignificant. State Space Models are much more advanced and can encode not only the amount and significance of the variability but also properties, such as slope, rise or decline for a given time t. In this work, we evaluate the effectiveness of State Space Models for transient and variable detection including classification in time-series astronomy. We also propose a method for detecting a transient source hosted in a variable active galaxy, whereby the time-series of a static host galaxy and the dynamic nature of the transient in the galaxy are intertwined. Furthermore, we examine the hypothetical scenario where the target transient we want to detect is the gravitational wave source GW170817 (or similar).

Published
2024
Full Text
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4. Evaluating Collaborative Autonomy in Opposed Environments using Maritime Capture-the-Flag Competitions

Author

Beason, Jordan, Novitzky, Michael, Kliem, John, Errico, Tyler, Serlin, Zachary, Becker, Kevin, Paine, Tyler, Benjamin, Michael, Dasgupta, Prithviraj, Crowley, Peter, O'Donnell, Charles, and James, John

Subjects
Computer Science - Robotics
Abstract

The objective of this work is to evaluate multi-agent artificial intelligence methods when deployed on teams of unmanned surface vehicles (USV) in an adversarial environment. Autonomous agents were evaluated in real-world scenarios using the Aquaticus test-bed, which is a Capture-the-Flag (CTF) style competition involving teams of USV systems. Cooperative teaming algorithms of various foundations in behavior-based optimization and deep reinforcement learning (RL) were deployed on these USV systems in two versus two teams and tested against each other during a competition period in the fall of 2023. Deep reinforcement learning applied to USV agents was achieved via the Pyquaticus test bed, a lightweight gymnasium environment that allows simulated CTF training in a low-level environment. The results of the experiment demonstrate that rule-based cooperation for behavior-based agents outperformed those trained in Deep-reinforcement learning paradigms as implemented in these competitions. Further integration of the Pyquaticus gymnasium environment for RL with MOOS-IvP in terms of configuration and control schema will allow for more competitive CTF games in future studies. As the development of experimental deep RL methods continues, the authors expect that the competitive gap between behavior-based autonomy and deep RL will be reduced. As such, this report outlines the overall competition, methods, and results with an emphasis on future works such as reward shaping and sim-to-real methodologies and extending rule-based cooperation among agents to react to safety and security events in accordance with human experts intent/rules for executing safety and security processes., Comment: Accepted to the IEEE ICRA Workshop on Field Robotics 2024

Published
2024

8. The James Webb Space Telescope Mission

Author

Gardner, Jonathan P., Mather, John C., Abbott, Randy, Abell, James S., Abernathy, Mark, Abney, Faith E., Abraham, John G., Abraham, Roberto, Abul-Huda, Yasin M., Acton, Scott, Adams, Cynthia K., Adams, Evan, Adler, David S., Adriaensen, Maarten, Aguilar, Jonathan Albert, Ahmed, Mansoor, Ahmed, Nasif S., Ahmed, Tanjira, Albat, Rüdeger, Albert, Loïc, Alberts, Stacey, Aldridge, David, Allen, Mary Marsha, Allen, Shaune S., Altenburg, Martin, Altunc, Serhat, Alvarez, Jose Lorenzo, Álvarez-Márquez, Javier, de Oliveira, Catarina Alves, Ambrose, Leslie L., Anandakrishnan, Satya M., Andersen, Gregory C., Anderson, Harry James, Anderson, Jay, Anderson, Kristen, Anderson, Sara M., Aprea, Julio, Archer, Benita J., Arenberg, Jonathan W., Argyriou, Ioannis, Arribas, Santiago, Artigau, Étienne, Arvai, Amanda Rose, Atcheson, Paul, Atkinson, Charles B., Averbukh, Jesse, Aymergen, Cagatay, Bacinski, John J., Baggett, Wayne E., Bagnasco, Giorgio, Baker, Lynn L., Balzano, Vicki Ann, Banks, Kimberly A., Baran, David A., Barker, Elizabeth A., Barrett, Larry K., Barringer, Bruce O., Barto, Allison, Bast, William, Baudoz, Pierre, Baum, Stefi, Beatty, Thomas G., Beaulieu, Mathilde, Bechtold, Kathryn, Beck, Tracy, Beddard, Megan M., Beichman, Charles, Bellagama, Larry, Bely, Pierre, Berger, Timothy W., Bergeron, Louis E., Darveau-Bernier, Antoine, Bertch, Maria D., Beskow, Charlotte, Betz, Laura E., Biagetti, Carl P., Birkmann, Stephan, Bjorklund, Kurt F., Blackwood, James D., Blazek, Ronald Paul, Blossfeld, Stephen, Bluth, Marcel, Boccaletti, Anthony, Boegner Jr., Martin E., Bohlin, Ralph C., Boia, John Joseph, Böker, Torsten, Bonaventura, N., Bond, Nicholas A., Bosley, Kari Ann, Boucarut, Rene A., Bouchet, Patrice, Bouwman, Jeroen, Bower, Gary, Bowers, Ariel S., Bowers, Charles W., Boyce, Leslye A., Boyer, Christine T., Boyer, Martha L., Boyer, Michael, Boyer, Robert, Bradley, Larry D., Brady, Gregory R., Brandl, Bernhard R., Brannen, Judith L., Breda, David, Bremmer, Harold G., Brennan, David, Bresnahan, Pamela A., Bright, Stacey N., Broiles, Brian J., Bromenschenkel, Asa, Brooks, Brian H., Brooks, Keira J., Brown, Bob, Brown, Bruce, Brown, Thomas M., Bruce, Barry W., Bryson, Jonathan G., Bujanda, Edwin D., Bullock, Blake M., Bunker, A. J., Bureo, Rafael, Burt, Irving J., Bush, James Aaron, Bushouse, Howard A., Bussman, Marie C., Cabaud, Olivier, Cale, Steven, Calhoon, Charles D., Calvani, Humberto, Canipe, Alicia M., Caputo, Francis M., Cara, Mihai, Carey, Larkin, Case, Michael Eli, Cesari, Thaddeus, Cetorelli, Lee D., Chance, Don R., Chandler, Lynn, Chaney, Dave, Chapman, George N., Charlot, S., Chayer, Pierre, Cheezum, Jeffrey I., Chen, Bin, Chen, Christine H., Cherinka, Brian, Chichester, Sarah C., Chilton, Zachary S., Chittiraibalan, Dharini, Clampin, Mark, Clark, Charles R., Clark, Kerry W., Clark, Stephanie M., Claybrooks, Edward E., Cleveland, Keith A., Cohen, Andrew L., Cohen, Lester M., Colón, Knicole D., Coleman, Benee L., Colina, Luis, Comber, Brian J., Comeau, Thomas M., Comer, Thomas, Reis, Alain Conde, Connolly, Dennis C., Conroy, Kyle E., Contos, Adam R., Contreras, James, Cook, Neil J., Cooper, James L., Cooper, Rachel Aviva, Correia, Michael F., Correnti, Matteo, Cossou, Christophe, Costanza, Brian F., Coulais, Alain, Cox, Colin R., Coyle, Ray T., Cracraft, Misty M., Noriega-Crespo, Alberto, Crew, Keith A., Curtis, Gary J., Cusveller, Bianca, Maciel, Cleyciane Da Costa, Dailey, Christopher T., Daugeron, Frédéric, Davidson, Greg S., Davies, James E., Davis, Katherine Anne, Davis, Michael S., Day, Ratna, de Chambure, Daniel, de Jong, Pauline, De Marchi, Guido, Dean, Bruce H., Decker, John E., Delisa, Amy S., Dell, Lawrence C., Dellagatta, Gail, Dembinska, Franciszka, Demosthenes, Sandor, Dencheva, Nadezhda M., Deneu, Philippe, DePriest, William W., Deschenes, Jeremy, Dethienne, Nathalie, Detre, Örs Hunor, Diaz, Rosa Izela, Dicken, Daniel, DiFelice, Audrey S., Dillman, Matthew, Disharoon, Maureen O., van Dishoeck, Ewine F., Dixon, William V., Doggett, Jesse B., Dominguez, Keisha L., Donaldson, Thomas S., Doria-Warner, Cristina M., Santos, Tony Dos, Doty, Heather, Douglas Jr., Robert E., Doyon, René, Dressler, Alan, Driggers, Jennifer, Driggers, Phillip A., Dunn, Jamie L., DuPrie, Kimberly C., Dupuis, Jean, Durning, John, Dutta, Sanghamitra B., Earl, Nicholas M., Eccleston, Paul, Ecobichon, Pascal, Egami, Eiichi, Ehrenwinkler, Ralf, Eisenhamer, Jonathan D., Eisenhower, Michael, Eisenstein, Daniel J., Hamel, Zaky El, Elie, Michelle L., Elliott, James, Elliott, Kyle Wesley, Engesser, Michael, Espinoza, Néstor, Etienne, Odessa, Etxaluze, Mireya, Evans, Leah, Fabreguettes, Luce, Falcolini, Massimo, Falini, Patrick R., Fatig, Curtis, Feeney, Matthew, Feinberg, Lee D., Fels, Raymond, Ferdous, Nazma, Ferguson, Henry C., Ferrarese, Laura, Ferreira, Marie-Héléne, Ferruit, Pierre, Ferry, Malcolm, Filippazzo, Joseph Charles, Firre, Daniel, Fix, Mees, Flagey, Nicolas, Flanagan, Kathryn A., Fleming, Scott W., Florian, Michael, Flynn, James R., Foiadelli, Luca, Fontaine, Mark R., Fontanella, Erin Marie, Forshay, Peter Randolph, Fortner, Elizabeth A., Fox, Ori D., Framarini, Alexandro P., Francisco, John I., Franck, Randy, Franx, Marijn, Franz, David E., Friedman, Scott D., Friend, Katheryn E., Frost, James R., Fu, Henry, Fullerton, Alexander W., Gaillard, Lionel, Galkin, Sergey, Gallagher, Ben, Galyer, Anthony D., Marín, Macarena García, Gardner, Lisa E., Garland, Dennis, Garrett, Bruce Albert, Gasman, Danny, Gáspár, András, Gastaud, René, Gaudreau, Daniel, Gauthier, Peter Timothy, Geers, Vincent, Geithner, Paul H., Gennaro, Mario, Gerber, John, Gereau, John C., Giampaoli, Robert, Giardino, Giovanna, Gibbons, Paul C., Gilbert, Karolina, Gilman, Larry, Girard, Julien H., Giuliano, Mark E., Gkountis, Konstantinos, Glasse, Alistair, Glassmire, Kirk Zachary, Glauser, Adrian Michael, Glazer, Stuart D., Goldberg, Joshua, Golimowski, David A., Gonzaga, Shireen P., Gordon, Karl D., Gordon, Shawn J., Goudfrooij, Paul, Gough, Michael J., Graham, Adrian J., Grau, Christopher M., Green, Joel David, Greene, Gretchen R., Greene, Thomas P., Greenfield, Perry E., Greenhouse, Matthew A., Greve, Thomas R., Greville, Edgar M., Grimaldi, Stefano, Groe, Frank E., Groebner, Andrew, Grumm, David M., Grundy, Timothy, Güdel, Manuel, Guillard, Pierre, Guldalian, John, Gunn, Christopher A., Gurule, Anthony, Gutman, Irvin Meyer, Guy, Paul D., Guyot, Benjamin, Hack, Warren J., Haderlein, Peter, Hagan, James B., Hagedorn, Andria, Hainline, Kevin, Haley, Craig, Hami, Maryam, Hamilton, Forrest Clifford, Hammann, Jeffrey, Hammel, Heidi B., Hanley, Christopher J., Hansen, Carl August, Hardy, Bruce, Harnisch, Bernd, Harr, Michael Hunter, Harris, Pamela, Hart, Jessica Ann, Hartig, George F., Hasan, Hashima, Hashim, Kathleen Marie, Hashimoto, Ryan, Haskins, Sujee J., Hawkins, Robert Edward, Hayden, Brian, Hayden, William L., Healy, Mike, Hecht, Karen, Heeg, Vince J., Hejal, Reem, Helm, Kristopher A., Hengemihle, Nicholas J., Henning, Thomas, Henry, Alaina, Henry, Ronald L., Henshaw, Katherine, Hernandez, Scarlin, Herrington, Donald C., Heske, Astrid, Hesman, Brigette Emily, Hickey, David L., Hilbert, Bryan N., Hines, Dean C., Hinz, Michael R., Hirsch, Michael, Hitcho, Robert S., Hodapp, Klaus, Hodge, Philip E., Hoffman, Melissa, Holfeltz, Sherie T., Holler, Bryan Jason, Hoppa, Jennifer Rose, Horner, Scott, Howard, Joseph M., Howard, Richard J., Huber, Jean M., Hunkeler, Joseph S., Hunter, Alexander, Hunter, David Gavin, Hurd, Spencer W., Hurst, Brendan J., Hutchings, John B., Hylan, Jason E., Ignat, Luminita Ilinca, Illingworth, Garth, Irish, Sandra M., Isaacs III, John C., Jackson Jr., Wallace C., Jaffe, Daniel T., Jahic, Jasmin, Jahromi, Amir, Jakobsen, Peter, James, Bryan, James, John C., James, LeAndrea Rae, Jamieson, William Brian, Jandra, Raymond D., Jayawardhana, Ray, Jedrzejewski, Robert, Jeffers, Basil S., Jensen, Peter, Joanne, Egges, Johns, Alan T., Johnson, Carl A., Johnson, Eric L., Johnson, Patricia, Johnson, Phillip Stephen, Johnson, Thomas K., Johnson, Timothy W., Johnstone, Doug, Jollet, Delphine, Jones, Danny P., Jones, Gregory S., Jones, Olivia C., Jones, Ronald A., Jones, Vicki, Jordan, Ian J., Jordan, Margaret E., Jue, Reginald, Jurkowski, Mark H., Justis, Grant, Justtanont, Kay, Kaleida, Catherine C., Kalirai, Jason S., Kalmanson, Phillip Cabrales, Kaltenegger, Lisa, Kammerer, Jens, Kan, Samuel K., Kanarek, Graham Childs, Kao, Shaw-Hong, Karakla, Diane M., Karl, Hermann, Kassin, Susan A., Kauffman, David D., Kavanagh, Patrick, Kelley, Leigh L., Kelly, Douglas M., Kendrew, Sarah, Kennedy, Herbert V., Kenny, Deborah A., Keski-Kuha, Ritva A., Keyes, Charles D., Khan, Ali, Kidwell, Richard C., Kimble, Randy A., King, James S., King, Richard C., Kinzel, Wayne M., Kirk, Jeffrey R., Kirkpatrick, Marc E., Klaassen, Pamela, Klingemann, Lana, Klintworth, Paul U., Knapp, Bryan Adam, Knight, Scott, Knollenberg, Perry J., Knutsen, Daniel Mark, Koehler, Robert, Koekemoer, Anton M., Kofler, Earl T., Kontson, Vicki L., Kovacs, Aiden Rose, Kozhurina-Platais, Vera, Krause, Oliver, Kriss, Gerard A., Krist, John, Kristoffersen, Monica R., Krogel, Claudia, Krueger, Anthony P., Kulp, Bernard A., Kumari, Nimisha, Kwan, Sandy W., Kyprianou, Mark, Labador, Aurora Gadiano, Labiano, Álvaro, Lafrenière, David, Lagage, Pierre-Olivier, Laidler, Victoria G., Laine, Benoit, Laird, Simon, Lajoie, Charles-Philippe, Lallo, Matthew D., Lam, May Yen, LaMassa, Stephanie Marie, Lambros, Scott D., Lampenfield, Richard Joseph, Lander, Matthew Ed, Langston, James Hutton, Larson, Kirsten, Larson, Melora, LaVerghetta, Robert Joseph, Law, David R., Lawrence, Jon F., Lee, David W., Lee, Janice, Lee, Yat-Ning Paul, Leisenring, Jarron, Leveille, Michael Dunlap, Levenson, Nancy A., Levi, Joshua S., Levine, Marie B., Lewis, Dan, Lewis, Jake, Lewis, Nikole, Libralato, Mattia, Lidon, Norbert, Liebrecht, Paula Louisa, Lightsey, Paul, Lilly, Simon, Lim, Frederick C., Lim, Pey Lian, Ling, Sai-Kwong, Link, Lisa J., Link, Miranda Nicole, Lipinski, Jamie L., Liu, XiaoLi, Lo, Amy S., Lobmeyer, Lynette, Logue, Ryan M., Long, Chris A., Long, Douglas R., Long, Ilana D., Long, Knox S., López-Caniego, Marcos, Lotz, Jennifer M., Love-Pruitt, Jennifer M., Lubskiy, Michael, Luers, Edward B., Luetgens, Robert A., Luevano, Annetta J., Lui, Sarah Marie G. Flores, Lund III, James M., Lundquist, Ray A., Lunine, Jonathan, Lützgendorf, Nora, Lynch, Richard J., MacDonald, Alex J., MacDonald, Kenneth, Macias, Matthew J., Macklis, Keith I., Maghami, Peiman, Maharaja, Rishabh Y., Maiolino, Roberto, Makrygiannis, Konstantinos G., Malla, Sunita Giri, Malumuth, Eliot M., Manjavacas, Elena, Marini, Andrea, Marrione, Amanda, Marston, Anthony, Martel, André R, Martin, Didier, Martin, Peter G., Martinez, Kristin L., Maschmann, Marc, Masci, Gregory L., Masetti, Margaret E., Maszkiewicz, Michael, Matthews, Gary, Matuskey, Jacob E., McBrayer, Glen A., McCarthy, Donald W., McCaughrean, Mark J., McClare, Leslie A., McClare, Michael D., McCloskey, John C., McClurg, Taylore D., McCoy, Martin, McElwain, Michael W., McGregor, Roy D., McGuffey, Douglas B., McKay, Andrew G., McKenzie, William K., McLean, Brian, McMaster, Matthew, McNeil, Warren, De Meester, Wim, Mehalick, Kimberly L., Meixner, Margaret, Meléndez, Marcio, Menzel, Michael P., Menzel, Michael T., Merz, Matthew, Mesterharm, David D., Meyer, Michael R., Meyett, Michele L., Meza, Luis E., Midwinter, Calvin, Milam, Stefanie N., Miller, Jay Todd, Miller, William C., Miskey, Cherie L., Misselt, Karl, Mitchell, Eileen P., Mohan, Martin, Montoya, Emily E., Moran, Michael J., Morishita, Takahiro, Moro-Martín, Amaya, Morrison, Debra L., Morrison, Jane, Morse, Ernie C., Moschos, Michael, Moseley, S. H., Mosier, Gary E., Mosner, Peter, Mountain, Matt, Muckenthaler, Jason S., Mueller, Donald G., Mueller, Migo, Muhiem, Daniella, Mühlmann, Prisca, Mullally, Susan Elizabeth, Mullen, Stephanie M., Munger, Alan J, Murphy, Jess, Murray, Katherine T., Muzerolle, James C., Mycroft, Matthew, Myers, Andrew, Myers, Carey R., Myers, Fred Richard R., Myers, Richard, Myrick, Kaila, Nagle IV, Adrian F., Nayak, Omnarayani, Naylor, Bret, Neff, Susan G., Nelan, Edmund P., Nella, John, Nguyen, Duy Tuong, Nguyen, Michael N., Nickson, Bryony, Nidhiry, John Joseph, Niedner, Malcolm B., Nieto-Santisteban, Maria, Nikolov, Nikolay K., Nishisaka, Mary Ann, Nota, Antonella, O'Mara, Robyn C., Oboryshko, Michael, O'Brien, Marcus B., Ochs, William R., Offenberg, Joel D., Ogle, Patrick Michael, Ohl, Raymond G., Olmsted, Joseph Hamden, Osborne, Shannon Barbara, O'Shaughnessy, Brian Patrick, Östlin, Göran, O'Sullivan, Brian, Otor, O. Justin, Ottens, Richard, Ouellette, Nathalie N. -Q., Outlaw, Daria J., Owens, Beverly A., Pacifici, Camilla, Page, James Christophe, Paranilam, James G., Park, Sang, Parrish, Keith A., Paschal, Laura, Patapis, Polychronis, Patel, Jignasha, Patrick, Keith, Pattishall Jr., Robert A., Paul, Douglas William, Paul, Shirley J., Pauly, Tyler Andrew, Pavlovsky, Cheryl M., Peña-Guerrero, Maria, Pedder, Andrew H., Peek, Matthew Weldon, Pelham, Patricia A., Penanen, Konstantin, Perriello, Beth A., Perrin, Marshall D., Perrine, Richard F., Perrygo, Chuck, Peslier, Muriel, Petach, Michael, Peterson, Karla A., Pfarr, Tom, Pierson, James M., Pietraszkiewicz, Martin, Pilchen, Guy, Pipher, Judy L., Pirzkal, Norbert, Pitman, Joseph T., Player, Danielle M., Plesha, Rachel, Plitzke, Anja, Pohner, John A., Poletis, Karyn Konstantin, Pollizzi, Joseph A., Polster, Ethan, Pontius, James T., Pontoppidan, Klaus, Porges, Susana C., Potter, Gregg D., Prescott, Stephen, Proffitt, Charles R., Pueyo, Laurent, Neira, Irma Aracely Quispe, Radich, Armando, Rager, Reiko T., Rameau, Julien, Ramey, Deborah D., Alarcon, Rafael Ramos, Rampini, Riccardo, Rapp, Robert, Rashford, Robert A., Rauscher, Bernard J., Ravindranath, Swara, Rawle, Timothy, Rawlings, Tynika N., Ray, Tom, Regan, Michael W., Rehm, Brian, Rehm, Kenneth D., Reid, Neill, Reis, Carl A., Renk, Florian, Reoch, Tom B., Ressler, Michael, Rest, Armin W., Reynolds, Paul J., Richon, Joel G., Richon, Karen V., Ridgaway, Michael, Riedel, Adric Richard, Rieke, George H., Rieke, Marcia, Rifelli, Richard E., Rigby, Jane R., Riggs, Catherine S., Ringel, Nancy J., Ritchie, Christine E., Rix, Hans-Walter, Robberto, Massimo, Robinson, Michael S., Robinson, Orion, Rock, Frank W., Rodriguez, David R., del Pino, Bruno Rodríguez, Roellig, Thomas, Rohrbach, Scott O., Roman, Anthony J., Romelfanger, Frederick J., Romo Jr., Felipe P., Rosales, Jose J., Rose, Perry, Roteliuk, Anthony F., Roth, Marc N., Rothwell, Braden Quinn, Rouzaud, Sylvain, Rowe, Jason, Rowlands, Neil, Roy, Arpita, Royer, Pierre, Rui, Chunlei, Rumler, Peter, Rumpl, William, Russ, Melissa L., Ryan, Michael B., Ryan, Richard M., Saad, Karl, Sabata, Modhumita, Sabatino, Rick, Sabbi, Elena, Sabelhaus, Phillip A., Sabia, Stephen, Sahu, Kailash C., Saif, Babak N., Salvignol, Jean-Christophe, Samara-Ratna, Piyal, Samuelson, Bridget S., Sanders, Felicia A., Sappington, Bradley, Sargent, B. A., Sauer, Arne, Savadkin, Bruce J., Sawicki, Marcin, Schappell, Tina M., Scheffer, Caroline, Scheithauer, Silvia, Scherer, Ron, Schiff, Conrad, Schlawin, Everett, Schmeitzky, Olivier, Schmitz, Tyler S., Schmude, Donald J., Schneider, Analyn, Schreiber, Jürgen, Schroeven-Deceuninck, Hilde, Schultz, John J., Schwab, Ryan, Schwartz, Curtis H., Scoccimarro, Dario, Scott, John F., Scott, Michelle B., Seaton, Bonita L., Seely, Bruce S., Seery, Bernard, Seidleck, Mark, Sembach, Kenneth, Shanahan, Clare Elizabeth, Shaughnessy, Bryan, Shaw, Richard A., Shay, Christopher Michael, Sheehan, Even, Sheth, Kartik, Shih, Hsin-Yi, Shivaei, Irene, Siegel, Noah, Sienkiewicz, Matthew G., Simmons, Debra D., Simon, Bernard P., Sirianni, Marco, Sivaramakrishnan, Anand, Slade, Jeffrey E., Sloan, G. C., Slocum, Christine E., Slowinski, Steven E., Smith, Corbett T., Smith, Eric P., Smith, Erin C., Smith, Koby, Smith, Robert, Smith, Stephanie J., Smolik, John L., Soderblom, David R., Sohn, Sangmo Tony, Sokol, Jeff, Sonneborn, George, Sontag, Christopher D., Sooy, Peter R., Soummer, Remi, Southwood, Dana M., Spain, Kay, Sparmo, Joseph, Speer, David T., Spencer, Richard, Sprofera, Joseph D., Stallcup, Scott S., Stanley, Marcia K., Stansberry, John A., Stark, Christopher C., Starr, Carl W., Stassi, Diane Y., Steck, Jane A., Steeley, Christine D., Stephens, Matthew A., Stephenson, Ralph J., Stewart, Alphonso C., Stiavelli, Massimo, Stockman Jr., Hervey, Strada, Paolo, Straughn, Amber N., Streetman, Scott, Strickland, David Kendal, Strobele, Jingping F., Stuhlinger, Martin, Stys, Jeffrey Edward, Such, Miguel, Sukhatme, Kalyani, Sullivan, Joseph F., Sullivan, Pamela C., Sumner, Sandra M., Sun, Fengwu, Sunnquist, Benjamin Dale, Swade, Daryl Allen, Swam, Michael S., Swenton, Diane F., Swoish, Robby A., Litten, Oi In Tam, Tamas, Laszlo, Tao, Andrew, Taylor, David K., Taylor, Joanna M., Plate, Maurice te, Van Tea, Mason, Teague, Kelly K., Telfer, Randal C., Temim, Tea, Texter, Scott C., Thatte, Deepashri G., Thompson, Christopher Lee, Thompson, Linda M., Thomson, Shaun R., Thronson, Harley, Tierney, C. M., Tikkanen, Tuomo, Tinnin, Lee, Tippet, William Thomas, Todd, Connor William, Tran, Hien D., Trauger, John, Trejo, Edwin Gregorio, Truong, Justin Hoang Vinh, Tsukamoto, Christine L., Tufail, Yasir, Tumlinson, Jason, Tustain, Samuel, Tyra, Harrison, Ubeda, Leonardo, Underwood, Kelli, Uzzo, Michael A., Vaclavik, Steven, Valenduc, Frida, Valenti, Jeff A., Van Campen, Julie, van de Wetering, Inge, Van Der Marel, Roeland P., van Haarlem, Remy, Vandenbussche, Bart, Vanterpool, Dona D., Vernoy, Michael R., Costas, Maria Begoña Vila, Volk, Kevin, Voorzaat, Piet, Voyton, Mark F., Vydra, Ekaterina, Waddy, Darryl J., Waelkens, Christoffel, Wahlgren, Glenn Michael, Walker Jr., Frederick E., Wander, Michel, Warfield, Christine K., Warner, Gerald, Wasiak, Francis C., Wasiak, Matthew F., Wehner, James, Weiler, Kevin R., Weilert, Mark, Weiss, Stanley B., Wells, Martyn, Welty, Alan D., Wheate, Lauren, Wheeler, Thomas P., White, Christy L., Whitehouse, Paul, Whiteleather, Jennifer Margaret, Whitman, William Russell, Williams, Christina C., Willmer, Christopher N. A., Willott, Chris J., Willoughby, Scott P., Wilson, Andrew, Wilson, Debra, Wilson, Donna V., Windhorst, Rogier, Wislowski, Emily Christine, Wolfe, David J., Wolfe, Michael A., Wolff, Schuyler, Wondel, Amancio, Woo, Cindy, Woods, Robert T., Worden, Elaine, Workman, William, Wright, Gillian S., Wu, Carl, Wu, Chi-Rai, Wun, Dakin D., Wymer, Kristen B., Yadetie, Thomas, Yan, Isabelle C., Yang, Keith C., Yates, Kayla L., Yeager, Christopher R., Yerger, Ethan John, Young, Erick T., Young, Gary, Yu, Gene, Yu, Susan, Zak, Dean S., Zeidler, Peter, Zepp, Robert, Zhou, Julia, Zincke, Christian A., Zonak, Stephanie, and Zondag, Elisabeth

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit., Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figures

Published
2023
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12. Determinants of teenage pregnancy in Malawi: a community-based case-control study

Author

James John Kalulu, Jeremot Masoambeta, and William Stones

Subjects
Teenage pregnancy, Adolescent pregnancy, Malawi., Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Teenage pregnancies are a global concern. Malawi is one of the countries with the highest teenage pregnancy rates despite government efforts to reverse the situation and yet studies on determinants of teenage pregnancy are rare with some factors remaining unexplored. Therefore, this study aimed to identify factors associated with teenage pregnancies in Malawi. Methods This was a community-based case-control study that used secondary data from the 2015-16 Malawi Demographic and Health Survey from all 28 districts of Malawi. The study population comprised women aged 20–24 who participated in the survey. The study ran from September 2021 to October 2022 and used a sample size of 3,435 participants who were all women aged 20–24 in the dataset who met the inclusion criteria. Data were analysed using Stata 16 software. Logistic regression analyses were used to determine factors. Variables with a P value of

Published
2024
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18. Recent Progress and Next Steps for the MATHUSLA LLP Detector

Author

Alpigiani, Cristiano, Arteaga-Velázquez, Juan Carlos, Ball, Austin, Barak, Liron, Barron, Jared, Batell, Brian, Beacham, James, Benhammo, Yan, Brau, Benjamin, Caballero-Mora, Karen Salomé, Camarri, Paolo, Cardarelli, Roberto, Chou, John Paul, Cui, Wentao, Curtin, David, Diamond, Miriam, Dienes, Keith R., Dougherty, Liam Andrew, Dougherty, William, Drewes, Marco, Erramilli, Sameer, Essig, Rouven, Etzion, Erez, Evans, Jared, Téllez, Arturo Fernández, Finlayson, Grace, Fischer, Oliver, Freeman, Jim, Gall, Jonathan, Garabaglu, Ali, Garcia-Bellido, Aran, Giagu, Stefano, Gomber, Bhawna, Greenberg, Stephen Elliott, Guida, Roberto, Haas, Andy, Hassan, Bahgat, Heng, Yuekun, Hsu, Shih-Chieh, Humphrey, Keegan, Iaselli, Giuseppe, Johns, Ken, Kvam, Audrey, Lazic, Dragoslav, Li, Liang, Liao, Jiahao, Liberti, Barbara, Liu, Zhen, Lubatti, Henry, Luo, Lillian, Marsella, Giovanni, Hernández, Mario Iván Martínez, McCullough, Matthew, McKeen, David, Meade, Patrick, Mizrachi, Gilad, Morales-Olivares, O. G., Morrissey, David, Morvai, Ljiljana, Moshe, Meny Raviv, Panagiotou, Michalis, Proffitt, Mason, Ramirez, Dennis Cazar, Reece, Matthew, Robertson, Steven H., Rodríguez-Cahuantzi, Mario, de Roeck, Albert, Roepe, Amber, Ruckman, Larry, Russell, James John, Russell, Heather, Saka, Halil, Santonico, Rinaldo, Schioppa, Marco, Di Sciascio, Giuseppe, Shelton, Jessie, Shuve, Brian, Silver, Yiftah, Di Stante, Luigi, Stolarski, Daniel, Strauss, Mike, Strom, David, Stupak, John, Vasquez, Martin A. Subieta, Swain, Sanjay Kumar, Tan, Chin Lung, Muñoz, Guillermo Tejeda, Thayil, Steffie Ann, Thomas, Brooks, Torro, Emma, Tsai, Yuhsin, Watts, Gordon, Xu, Zijun, Young, Charles, Zolkin, Igor, and Zurita, Jose

Subjects
High Energy Physics - Experiment
Abstract

We report on recent progress and next steps in the design of the proposed MATHUSLA Long Lived Particle (LLP) detector for the HL-LHC as part of the Snowmass 2021 process. Our understanding of backgrounds has greatly improved, aided by detailed simulation studies, and significant R&D has been performed on designing the scintillator detectors and understanding their performance. The collaboration is on track to complete a Technical Design Report, and there are many opportunities for interested new members to contribute towards the goal of designing and constructing MATHUSLA in time for HL-LHC collisions, which would increase the sensitivity to a large variety of highly motivated LLP signals by orders of magnitude., Comment: Contribution to Snowmass 2021 (EF09, EF10, IF6, IF9), 18 pages, 12 figures. v2: included additional endorsers. v3: updated affiliations. v4: added missing contributors as authors

Published
2022

22. CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells

Author

Marcinek, Anetta, Brauchle, Bettina, Rohrbacher, Lisa, Hänel, Gerulf, Philipp, Nora, Märkl, Florian, Strzalkowski, Thaddäus, Lacher, Sonja M., Udiljak, Dragica, Spiekermann, Karsten, Theurich, Sebastian, Kobold, Sebastian, Kischel, Roman, James, John R., Bücklein, Veit L., and Subklewe, Marion

Published
2023
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23. Catholic School Educators as Adaptive Leaders: A Structure for Prophetic Action in Response to COVID-19

Author

James, John T.

Abstract

This article shares the perspectives of Catholic educational practitioners in the United States as they responded to the challenges of COVID-19. The article then turns to the challenges for practitioners ahead and suggests a prophetic response utilizing the adaptive leadership framework. It outlines some of the issues and questions that must be addressed for the Fall semester. It concludes with references to scripture, Pope Francis, and others regarding a prophetic response to COVID-19 as a tempestuous sea.

Published
2020

24. Reconstructing the queen's household, 1485-1547 : a study in royal service

Author

Taffe, James John

Abstract

This thesis examines the queen's household in England and the careers of its servants from 1485 to 1547. Reconstructing the offices they held in the queen's Chamber and Privy Chamber, and their relationships with the queen, their mistress, the king, their sovereign, and the wider court and kingdom, it reassesses and redefines our understanding of the nature of royal service. This thesis builds upon the wider historiography on queenship, politics and women in this period. It demonstrates that the study of monarchy must constitute the sovereign and their consort, and reiterates the importance of studying servants, and women, reinstating them as central to the reigns of Henry VII and Henry VIII. In order to conceptualise fully the political, religious, and cultural significance of the court, not strictly the king's servants, but the queen's servants too, must be studied. Six women served as queens consort during Henry VIII's reign, and their households were situated at the centre of their rise and fall. This thesis investigates the impact of Henry VIII's marital instability, which saw the queen's household discharged, its servants disbanded, and many of their careers cut short on no less than five occasions between 1527 and 1547. Requiring new and extensive archival research to reconstruct the households of Henry VIII's queens, this thesis constructs a database of servants for prosopographical study, and integrates them into the master narrative of court studies. Rethinking and reflecting upon royal service more broadly as a career, this thesis provides a framework through which to interpret the evidence of service more sensitively, and accurately. It recommends ongoing and in-depth research into their individual careers, with a more nuanced understanding of the nature of royal service, and of the Tudor court from 1485 to 1603.

Published
2022

26. Analysis of complex flows in safety valves using CFD

Author

Doyle, Christopher James John and Dempster, William

Abstract

The aim of this thesis was to utilise Computational Fluid Dynamics (CFD) tools available to industry - primarily ANSYS FLUENT and ANSYS Workbench - to develop a modelling methodology which could allow CFD to be relied upon and be used as an analysis/design tool within the Pressure Relief Valve (PRV) industry. This work will also investigate the capability and resilience of modern day CFD solvers to accurately capture the array of complex flow dynamics which exist during the operation of various types of PRV's. Furthermore, to achieve confidence in the capability of the CFD models developed; it was required for experimental validation work to be performed. Initially a 3D single phase (air only) steady state CFD model was developed for a right-angled type 3511E PRV manufactured by Broady Flow Control and validated against experimental results generated at an industrial testing facility. In addition, by developing upon previous 2D CFD work at the University of Strathclyde for a smaller through flow type PRV geometry; the lessons learned from the Broady PRV research allowed a 3D CFD model to be developed for a 5231BX through flow type PRV manufactured by Henry Group Industries. Experimental validation for the 5231BX PRV was performed at a testing facility developed within the flow laboratory at Strathclyde. For both cases, good correlation for air mass flow rate and disc/piston aerodynamic force with experimental results was achieved. Furthermore, from the validation analysis performed for the Henry PRV it was highlighted that a significant improvement in CFD modelling accuracy could be achieved by adopting a 3D CFD model when compared with 2D. This was due to a significant variation in complex flow features found at the piston surface and presence of symmetry breaking flow phenomena. Due to the success of the 3D steady state CFD models to accurately capture flow features for both the Broady and Henry PRV's, a transient single phase CFD model was developed to enable the use of a dynamic moving mesh to capture each PRV's operational characteristics. The experimental facilities developed for both PRV's allowed a validation of the CFD model's prediction for overpressure, blowdown and overall dynamic characteristics (disc lift vs time). For both cases it was found that overpressure and blowdown could be predicted closely as well as a general consensus being achieved for lift vs time behaviour. Therefore, it was concluded that for both types of PRV geometry, a moving mesh was capable to accurately capture the dynamic PRV response. For the Henry case however there was vibration in the CFD results which was attributed due to numerical errors induced by the RANS CFD numerical model. Following the dynamic mesh analysis for the Henry PRV; a study of the validity of the commonly used quasi steady design approach to PRV's was examined by comparing results from steady state to dynamic operating conditions. The conclusion from this study highlighted a potentially significant issue with current typical PRV design practices as different magnitudes of disc force could be attributed with disc velocity when compared with steady state results. This would therefore cause a difference in expected performance from quasi steady based simple dynamic models often used in initial valve design. In addition, two-phase (air-water) 3D CFD analysis was performed for the Henry 5231BX PRV to extend previous 2D CFD research at Strathclyde. Both steady state and transient experimental testing was performed for a range of water injection rates; however only two phase steady state CFD validation was undertaken due to computational restrictions. The two-phase steady state validation results highlighted that a 3D CFD model, which utilised the homogenous mixture model, was capable of achieving a reasonably accurate correlation to experimental data across the full lift range when subjected to a water injection rate of 0.96 L/min and 2.1 L/min. Degradation in accuracy could be found for two-phase CFD modelling when compared to single phase modelling; however correlation was generally within acceptable limits. Furthermore, from two phase transient experimental testing; it was possible to establish a direct trend of water injection rate/water mass fraction to the dynamic characteristics of the Henry PRV as well as blowdown pressure. The effect of two phase operation on dynamic stability was also established.

Published
2022
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29. The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions

Author

Georas, Steve N, Wright, Rosalind J, Ivanova, Anastasia, Israel, Elliot, LaVange, Lisa M, Akuthota, Praveen, Carr, Tara F, Denlinger, Loren C, Fajt, Merritt L, Kumar, Rajesh, O’Neal, Wanda K, Phipatanakul, Wanda, Szefler, Stanley J, Aronica, Mark A, Bacharier, Leonard B, Burbank, Allison J, Castro, Mario, Alexander, Laura Crotty, Bamdad, Julie, Cardet, Juan Carlos, Comhair, Suzy AA, Covar, Ronina A, DiMango, Emily A, Erwin, Kim, Erzurum, Serpil C, Fahy, John V, Gaffin, Jonathan M, Gaston, Benjamin, Gerald, Lynn B, Hoffman, Eric A, Holguin, Fernando, Jackson, Daniel J, James, John, Jarjour, Nizar N, Kenyon, Nicholas J, Khatri, Sumita, Kirwan, John P, Kraft, Monica, Krishnan, Jerry A, Liu, Andrew H, Liu, Mark C, Marquis, M Alison, Martinez, Fernando, Mey, Jacob, Moore, Wendy C, Moy, James N, Ortega, Victor E, Peden, David B, Pennington, Emily, Peters, Michael C, Ross, Kristie, Sanchez, Maria, Smith, Lewis J, Sorkness, Ronald L, Wechsler, Michael E, Wenzel, Sally E, White, Steven R, Zein, Joe, Zeki, Amir A, Noel, Patricia, Billheimer, Dean, Bleecker, Eugene R, Branch, Emily, Conway, Michelle, Daines, Cori, Deaton, Isaac, Evans, Alexandria, Field, Paige, Francisco, Dave, Hastie, Annette T, Hmieleski, Bob, Krings, Jeffrey O, Liu, Yanqin, Merchen, Janell L, Meyers, Deborah A, Narendran, Nirushan, Peters, Stephen P, Pippins, Anna, Rank, Matthew A, Schunk, Ronald, Skeps, Raymond, Wright, Benjamin, Banzon, Tina M, Bartnikas, Lisa M, Baxi, Sachin N, Betapudi, Vishwanath, Brick, Isabelle, Brockway, Conor, Casale, Thomas B, Castillo-Ruano, Kathleen, Cinelli, Maria Angeles, Crestani, Elena, Cunningham, Amparito, Day-Lewis, Megan, Diaz-Cabrera, Natalie, DiMango, Angela, Esty, Brittany, Fandozzi, Eva, Fernandez, Jesse, and Fitzpatrick, Elizabeth

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Lung, Precision Medicine, Asthma, Clinical Trials and Supportive Activities, Respiratory, Good Health and Well Being, Advisory Committees, Biomarkers, Clinical Protocols, Clinical Trials, Phase II as Topic, Humans, Research Design, Severity of Illness Index, Tomography, X-Ray Computed, Severe asthma, precision medicine, adaptive clinical trial design, asthma exacerbation, type 2 asthma, non-type 2 asthma, patient advisory committee, biomarker, PrecISE Study Team, non–type 2 asthma, Immunology, Allergy
Abstract

Asthma is a heterogeneous disease, with multiple underlying inflammatory pathways and structural airway abnormalities that impact disease persistence and severity. Recent progress has been made in developing targeted asthma therapeutics, especially for subjects with eosinophilic asthma. However, there is an unmet need for new approaches to treat patients with severe and exacerbation-prone asthma, who contribute disproportionately to disease burden. Extensive deep phenotyping has revealed the heterogeneous nature of severe asthma and identified distinct disease subtypes. A current challenge in the field is to translate new and emerging knowledge about different pathobiologic mechanisms in asthma into patient-specific therapies, with the ultimate goal of modifying the natural history of disease. Here, we describe the Precision Interventions for Severe and/or Exacerbation-Prone Asthma (PrecISE) Network, a groundbreaking collaborative effort of asthma researchers and biostatisticians from around the United States. The PrecISE Network was designed to conduct phase II/proof-of-concept clinical trials of precision interventions in the population with severe asthma, and is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health. Using an innovative adaptive platform trial design, the PrecISE Network will evaluate up to 6 interventions simultaneously in biomarker-defined subgroups of subjects. We review the development and organizational structure of the PrecISE Network, and choice of interventions being studied. We hope that the PrecISE Network will enhance our understanding of asthma subtypes and accelerate the development of therapeutics for severe asthma.

Published
2022

30. Trends in Extension in Australia

Author

van Bommel, Séverine, Coutts, Jeff, James, John, Nettle, Ruth, Brinkmann, Robert, Series Editor, Baldwin, Claudia, editor, and van Bommel, Séverine, editor

Published
2023
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32. An Update to the Letter of Intent for MATHUSLA: Search for Long-Lived Particles at the HL-LHC

Author

Alpigiani, Cristiano, Arteaga-Velázquez, Juan Carlos, Ball, Austin, Barak, Liron, Barron, Jared, Batell, Brian, Beacham, James, Benhammo, Yan, Caballero-Mora, Karen Salomé, Camarri, Paolo, Cardarelli, Roberto, Chou, John Paul, Cui, Wentao, Curtin, David, Diamond, Miriam, Dienes, Keith R., Dougherty, Liam Andrew, Di Sciascio, Giuseppe, Drewes, Marco, Etzion, Erez, Essig, Rouven, Evans, Jared, Téllez, Arturo Fernández, Fischer, Oliver, Freeman, Jim, Gall, Jonathan, Garabaglu, Ali, Giagu, Stefano, Greenberg, Stephen Elliott, Gomber, Bhawna, Guida, Roberto, Haas, Andy, Heng, Yuekun, Hsu, Shih-Chieh, Iaselli, Giuseppe, Johns, Ken, Kvam, Audrey, Lazic, Dragoslav, Li, Liang, Liberti, Barbara, Liu, Zhen, Lubatti, Henry, Luo, Lillian, Marsella, Giovanni, Hernández, Mario Iván Martínez, McCullough, Matthew, McKeen, David, Meade, Patrick, Mizrachi, Gilad, Morales-Olivares, O. G., Morrissey, David, Moshe, Meny Raviv, Policicchio, Antonio, Proffitt, Mason, Ramirez, Dennis Cazar, Reece, Matthew, Robertson, Steven H., Rodríguez-Cahuantzi, Mario, de Roeck, Albert, Roepe, Amber, Rothberg, Joe, Russell, James John, Russell, Heather, Santonico, Rinaldo, Schioppa, Marco, Shelton, Jessie, Shuve, Brian, Silver, Yiftah, Di Stante, Luigi, Stolarski, Daniel, Strauss, Mike, Strom, David, Stupak, John, Vasquez, Martin A. Subieta, Swain, Sanjay Kumar, Muñoz, Guillermo Tejeda, Thayil, Steffie Ann, Thomas, Brooks, Tsai, Yuhsin, Torro, Emma, Watts, Gordon, Young, Charles, and Zurita, Jose

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We report on recent progress in the design of the proposed MATHUSLA Long Lived Particle (LLP) detector for the HL-LHC, updating the information in the original Letter of Intent (LoI), see CDS:LHCC-I-031, arXiv:1811.00927. A suitable site has been identified at LHC Point 5 that is closer to the CMS Interaction Point (IP) than assumed in the LoI. The decay volume has been increased from 20 m to 25 m in height. Engineering studies have been made in order to locate much of the decay volume below ground, bringing the detector even closer to the IP. With these changes, a 100 m x 100 m detector has the same physics reach for large c$\tau$ as the 200 m x 200 m detector described in the LoI and other studies. The performance for small c$\tau$ is improved because of the proximity to the IP. Detector technology has also evolved while retaining the strip-like sensor geometry in Resistive Plate Chambers (RPC) described in the LoI. The present design uses extruded scintillator bars read out using wavelength shifting fibers and silicon photomultipliers (SiPM). Operations will be simpler and more robust with much lower operating voltages and without the use of greenhouse gases. Manufacturing is straightforward and should result in cost savings. Understanding of backgrounds has also significantly advanced, thanks to new simulation studies and measurements taken at the MATHUSLA test stand operating above ATLAS in 2018. We discuss next steps for the MATHUSLA collaboration, and identify areas where new members can make particularly important contributions., Comment: 22 pages + references, 12 Figures

Published
2020

33. NIMBUS study protocol: a single-centre feasibility study of non-invasive monitoring with bowel ultrasound in paediatric inflammatory bowel disease

Author

R Mark Beattie, James John Ashton, Alison Evans, Amar Wahid, Martin Oliver Edwards, Zachary Green, and Ella Mayberry

Subjects
Medicine
Abstract

Introduction Incidence of inflammatory bowel disease (IBD) is increasing in childhood and treatment increasingly targets mucosal healing. Monitoring bowel inflammation requires endoscopy or MRI enterography which are invasive, expensive and have long waiting lists.We aim to examine the feasibility of a non-invasive monitoring tool—bowel ultrasound (BUS)—in children with IBD and explore correlations with inflammatory markers and disease activity measures. Some BUS criteria have been found to correlate with these markers; however, this has not been validated in children.We aim to examine the feasibility of BUS for monitoring inflammation in this population; highlighting useful parameters for this purpose. We aim to inform a larger scale randomised controlled trial using BUS.Methods and analysis This prospective observational feasibility study will be carried out over 24 months at the Noah’s Ark Children’s Hospital for Wales, Cardiff; with the endpoint recruitment of 50 participants. Children aged 2–18 years with a modified Porto criteria diagnosis of IBD will be included.Patients without IBD or who have previously undergone IBD-related surgery will be excluded; as will families unable to give informed consent.Ultrasound scan images and reports will be collected, as well as laboratory results and clinical outcomes.The primary aim will assess the feasibility of targeted BUS for disease monitoring; including recruitment statistics. The secondary aims will involve data collection and correlation analysis for targeted ultrasound parameters, biomarkers, disease activity scores and prediction of changes in treatment. The statistical methods will include: feasibility metrics, descriptive statistics, cross-tabulation and χ2 analysis, correlation analysis, regression analysis.Ethics and dissemination Ethical approval is granted by NHS Research Ethics Committee. The sponsor is Cardiff and Vale University Health Board. We will publish the results in a peer-reviewed medical journal.Trial registration number NCT05673278.

Published
2023
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35. An Historical Review of the Professional and Distinctive Formation for Catholic School Educators in the United States

Author

James, John T.

Abstract

This article examines the historical context of the growth and development of Catholic education in the United States, and the commitment of Catholic colleges and universities -- viewed primarily through the lens of Jesuit Colleges and Universities -- to the professional formation of educators for service in Catholic schools. It is a story of the careful navigation by strangers in a strange land to create an unparalleled system of educational institutions, securing academic recognition through accreditation, and providing service to the K-12 Catholic educational system through the delivery of distinctive professional formation programmes for Catholic school educators. These historical challenges continue to the present day and represent a particular mission-driven service of Catholic higher education to the Catholic Church.

Published
2022
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36. Student Engagement, Experience, & Support among Pre-Pharmacy Students

Author

James John Stack

Abstract

This study was guided by Astin's Student Involvement theory which explored student's needs in a demanding program amongst 12 pre-pharmacy students at the University of the Pacific. This qualitative study looked to uncover the engagement, experiences, and support of pre-pharmacy students in order to learn what students want from their learning experiences; to aid in student success and retention. Qualitative interviews provided detailed stories to their pre-pharmacy experiences. Through a thorough analysis of the data seven themes emerged: (a) peer support (b) time management (c) exam structure (d) increased faculty support (e) housing placement (f) coping with stress (g) core classes. Students who were interviewed often-mentioned that their peers, who once were in situations similar to those that they found themselves in, helped them stay in the program. Many of the students had mentioned the importance of time management in a pre-pharmacy course. The students also mentioned that they had exams back-to-back, and it was a challenge for many of them to be prepared for all of them. The faculty has been associated with student success, and their being available for the students is important in fostering better outcomes for students. Learning how students are impacted by their housing experiences is important to understand because it connects to their classroom behaviors. Coping with stress was mentioned through many themes, and the ability of the students to deal with that stress was important to their success. It was important to understand what the students find useful from their non-science courses to learn what they desire from their learning experiences. The results from this study provide improvements to the students experiences and needs. The recommendations include the University of the Pacific adjusting the current curriculum when they are developing their exam schedules. Adding a course that aids in support for students focusing on time management, and as well preparation for students to encourage their school and social life balance. Having faculty available after class Q&A and providing online or in-person office hour sessions will aid in the student's success. This will allow flexibility for interactions between faculty and students. Housing facilities should have more late-night study areas, like in the Chan Hall Apartments that the PharmD students currently have. There should also be housing placements that are specifically designated for STEM students. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]

Published
2022

40. Evaluation and application of methodology for omic imputation into genome-wide association studies of complex human traits to infer potential causal mechanisms

Author

Fryett, James John

Abstract

To date, genome-wide association studies (GWAS) have been successful at identifying associations between common genetic variants and complex traits. However, little is known about the mechanisms by which trait-associated variants identified through GWAS affect the traits. One method developed to address this problem is the transcriptome-wide association study (TWAS), in which known relationships between genotypes and gene expression are leveraged to impute gene expression levels into GWAS samples. These imputed gene expression levels are then tested for association with traits to identify potentially causal trait-associated genes. Here, I investigated a number of ways of improving TWAS to enable the detection of more trait-associated genes, before extending the TWAS approach to investigate other omics measurements. First, to identify the best software for conducting TWAS, a range of packages were compared through application to data from the Geuvadis and Wellcome Trust Case Control Consortium projects. Overall, the investigated packages predicted gene expression with similar accuracy and detected similar expression-trait associations, although some tested a broader set of genes, so were preferable. Following this, the accuracy with which gene expression could be predicted from genotype data was investigated by comparing different statistical modelling approaches using data from the Geuvadis project. Overall, the expression of most genes could not be predicted accurately using any approach, but the best estimates were achieved when using approaches that assumed sparsity. Furthermore, prediction accuracy was improved by increasing sample size and by carefully matching training and testing data in terms of ancestry and tissue. Finally, the TWAS approach was extended to investigate the prediction of other omics measurements from genotype data. By generating prediction models for these omics measurements and applying these models to publicly available GWAS data, many associations between omics measurements and complex traits were detected, improving understanding of the mechanisms underlying GWAS risk loci.

Published
2020

41. Thermoplastic resin transfer moulding of tough recyclable composites for high volume manufacturing

Author

Murray, James John, O Brádaigh, Conchúr, and McCarthy, Edward

Subjects
thermoplastic, composite, TP-RTM, APA-6, nylon, resin, transfer, moulding, reactive, injection, T-RTM
Abstract

The aim of this project was to develop tough thermoplastic composite materials and moulding processes aimed at high rate production applications. The use of anionically polymerised polyamide 6 (APA-6) as a matrix in continuous fibre reinforced composites, manufactured using thermoplastic resin transfer moulding (TP-RTM) was investigated. The requirements for high speed manufacturing of composite parts and the importance of the polymer matrix choice in terms of temperature and pressure were outlined. In order to manufacture laminates, a TP-RTM setup had to be designed and built. The system designed consisted of a mixing/injection unit with a set of tanks and pumps heated above the melt temperature of the raw materials. During infusion of a composite part, the materials would be melted in the tanks, pumped through a mixing head for homogenising and delivered to the mould which contained a textile. Together, the system is capable of producing 340 mm x 390 mm panels with varying thicknesses, depending on that desired. Decisions for the choice of raw materials, their mixing ratios and processing temperatures were outlined. These decisions were based on literature and experiments carried out in order to produce a tough matrix material suitable for its purpose. 4 mm thick polymer plates were manufactured using the TP-RTM system and were characterised in terms of their chemical, thermo-morphological and mechanical properties. The distribution of thickness and density across plates was studied to better understand the effects of the mould geometry, molten flow and heat transfer on the degree of shrinkage in the material. It was found from this work that the APA-6 had a melt temperature of ~219 °C, glass transition temperature of ~70-85 °C and degree of crystallinity of ~42%. The tensile strength and modulus of the APA-6 were found to be ~83 MPa and 2.8 GPa respectively. Following analysis and testing of pure APA-6, unidirectional composite laminates were manufactured using the TP-RTM system. A non-crimp stitched glass fabric was used such that fibre volume fractions of approximately 51-52% would be achieved. As for the pure polymer, the distribution of thickness and density was determined across laminates. Likewise, the thermo-morphological properties were determined and compared with those of the pure polymer to determine the role of the fibres and the degree to which they effect the matrix properties. Finally, extensive mechanical testing was carried out to determine the transverse and longitudinal properties of the composite. In order to observe the effects of flow during manufacture on the final internal geometry of the composite, X-ray CT and micro section studies were carried out. The studies confirmed the presence of asmall percentage of voids in the materials as a result of the stitching and determined the degree to which this effected the properties. The mechanical properties of the composite compared extremely well with similar products which are commercially available. The strength and modulus of the composite were ~1109 MPa and ~41 GPa in tension respectively and ~691 MPa and ~42 GPa in compression respectively. The effects of different fibre sizings on fibre-matrix interface was investigated. Two different sizing types were looked at, one of which consisted of a reactive coating which would theoretically result in greater bonding. Firstly, scanning electron microscopy and atomic force microscopy of the fibres was carried out to observe distribution of the sizings on fibres at the microscale and nanoscale respectively. Thermogravimetric analysis was carried out to determine the temperature at which oxidation occurred in each sizing. Pyrolysis was carried out on larger quantities of fibres to determine the amount of sizing by mass on each fibre type. Unidirectional composite laminates using both fibre types were manufactured and tested to determine the effects on transverse, interlaminar shear and fracture toughness properties. The results indicated that the composite with the reactive sizing performed around 16% better in terms of strength on average but showed little difference in modulus. Results from testing indicated that it might also perform better in terms of Mode I fracture toughness; however, high scatter in results meant that this was inconclusive. Finally, quasi-isotropic laminates were manufactured using both of the aforementioned fibre sizing types and the effects of out-of-plane impact were investigated. Tests were firstly carried out on the pure APA-6 material and were compared to those for a standard epoxy in terms of energy absorption and force induced due to impact. The epoxy only absorbed around 44% the amount of energy before fracture compared to the APA-6. Laminates made using both fibre types were compared by testing at different energy levels and carrying out post-impact mechanical tests. The fibre type wasn't shown to significantly influence the energy absorbed by the materials before break; although, differences in the nature of failure were observed. Carbon fibre laminates made from both APA-6 and epoxy matrices were manufactured and tested to measure energy absorption and force induced in each. The epoxy composite absorbed around 84% the amount of energy before fracture compared to the APA-6 composite. Overall, it is shown that thermoplastic composites with excellent strength, toughness and impact performance were manufactured using a production process with potential for high production rates. Unidirectional laminates were produced using injection pressures of around 10% of those required to achieve the same fibre volume fraction and degree of wet-out using a typical thermoset RTM resin, negating the need for expensive equipment.

Published
2020
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42. Integration of genomic variation, ileal transcriptomics and longitudinal clinical data in paediatric inflammatory bowel disease

Author

Ashton, James John, Ennis, Sarah, Beattie, R. Mark, Cleary, David, and Polak, Marta

Abstract

Inflammatory bowel disease (IBD) is a chronic relapsing and remitting condition characterised by intestinal inflammation. IBD is considered a complex condition, arising from interaction between host genetic susceptibility, immune dysregulation and environmental stimuli in the form of intestinal bacteria. Paediatric onset disease is heterogenous and patients often follow an unpredictable severe course requiring immunosuppression, biological therapy or surgery. Utilising multi‐omic and clinical data to predict disease course and complicated phenotypes, such as stricturing and fistulating disease, has the potential to provide a route to personalised therapy and improved patient outcomes. This thesis describes the integration of genomic, targeted terminal ileal transcriptomics and longitudinal clinical data in paediatric patients with IBD. These chapters utilise a cohort of 96 individuals with intestinal biopsies including treatment naïve patients, established disease patients and control recruited during this PhD, alongside data derived from 501 patients with whole exome sequencing. This thesis identifies novel groupings of patients determined by blood results at diagnosis. We identify a precise molecular diagnosis in 8% of patients through interrogation of variation in monogenic IBD genes, and directly link monogenic NOD2‐disease to a stricturing phenotype. Utilising the whole gene deleteriousness score, GenePy, we provide evidence for a digenic risk of development of fistulating disease in small subset of patients with high burden of variation in NCF4 and NOD2, or in the NOX4 NAPDH complex. Through targeted autoimmune transcriptomic analysis of terminal ileal biopsies we identify an upregulation of IL17 and NOD‐signalling genes in treatment naïve Crohn's disease patients. Through single cell sequencing of two individuals we determine a small population of specialised ileal epithelial cells driving the IL17‐signalling signature. Finally, through integration of exome and transcriptomic data we identify variation across the NOD‐signalling pathway, including in NOD2, ATG16L1 and the TAK1‐TAB complex that directly impacts on ileal transcription, leading to an overall hypoinflammatory response. It is increasingly clear that IBD pathogenesis is private to an individual, or a cluster of individuals. Whilst activated inflammatory pathways demonstrate commonality, the underlying cause of disease may relate to deleterious variation in many genes across implicated pathways. This genetic variation leads to an inability to clear bacteria, resulting in chronic activated inflammation through alternative immune pathways. Genetic stratification also provides the ability to predict phenotypes. The next step is translating these findings into clinical practice.

Published
2020

44. Correction to: CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells

Author

Marcinek, Anetta, Brauchle, Bettina, Rohrbacher, Lisa, Hänel, Gerulf, Philipp, Nora, Märkl, Florian, Strzalkowski, Thaddäus, Lacher, Sonja M., Udiljak, Dragica, Spiekermann, Karsten, Theurich, Sebastian, Kobold, Sebastian, Kischel, Roman, James, John R., Bücklein, Veit L., and Subklewe, Marion

Published
2023
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45. Switching to second line MS disease-modifying therapies is associated with decreased relapse rate

Author

James John Marriott, Okechukwu Ekuma, Randall Fransoo, and Ruth Ann Marrie

Subjects
multiple sclerosis, disease-modifying therapy, treatment efficacy, MS relapse, MS epidemiology, Neurology. Diseases of the nervous system, RC346-429
Abstract

Background and objectivesWhile randomized, controlled trials (RCTs) are the gold standard for determining treatment efficacy, they do not capture the effectiveness of treatment during real-world use. We aimed to evaluate the association between demographics and multiple sclerosis (MS) disease-modifying therapy (DMT) exposure, including treatment adherence and switches between different DMTs, on the risk of subsequent MS relapse.MethodsAll persons with relapsing-onset MS (pwRMS) living in Manitoba between 1999 and 2014 were identified from provincial healthcare databases using a validated case definition. Use of DMTs was abstracted from the provincial drug database covering all residents of Manitoba, including use of any DMT, stopping/starting any DMT, switches between different DMTs and adherence as defined by cumulative medication possession ratios (CUMMPRs) of 50, 70, 80 and 90%. Time to first-treated relapse was used as the outcome of interest in logistic regression and Cox-proportional hazards regression models adjusting for demographic covariates including age and year of diagnosis, sex, socioeconomic status and number of medical comorbidities.Results1780 pwRMS were identified, including 1,510 who were on DMT at some point in the study period. While total DMT exposure was not associated with the time to subsequent treated relapse, individuals who switched between more than 2 DMTs had higher post-switch rates of relapse. Switching to second-line DMTs was associated with a longer time to treated relapse in comparison to those who remained on a first-line DMT (HR 0.44; 95%CI: 0.32–0.62, p

Published
2023
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46. Immune cell ratio and coagulation markers in assessing prognosis of asthma: a cross-sectional study from Saudi Arabia

Author

Fahad M. Aldakheel, Zamil A. Alruwaili, Shatha A. Alduraywish, Amal F. Alshammary, Ayesha Mateen, Rabbani Syed, and James John

Subjects
asthma, coagulation, d-dimer, immune cell ratio, Saudi Arabia, Immunologic diseases. Allergy, RC581-607
Abstract

Asthma affects a significant number of individuals in Saudi Arabia, with increasing prevalence worldwide, leading to a considerable impact on their quality of life and frequent hospitalizations. In this study, we aimed to explore the relationship between the immune cell ratio and coagulation markers, specifically to identify the occurrence of coagulation abnormalities associated with asthma. To achieve this, we assessed asthma history and severity using a questionnaire while analyzing coagulation biomarkers through venous blood samples. The biomarkers examined included d-dimer, prothrombin time (PT), partial thromboplastin time (PTT), and the international normalized ratio (INR). In addition, we evaluated various hematological parameters such as blood cell counts and hemoglobin (HGB) levels. Our findings revealed compelling evidence, showing significantly elevated levels of d-dimer and the eosinophil-to-neutrophil (ENR) ratio in asthma cases compared to the controls. Moreover, we observed a positive correlation between d-dimer levels and the ENR, with each unit increase in d-dimer associated with a 0.0006 increase in the ENR among asthma cases. These results highlight the potential of assessing ENR and d-dimer levels as predictive indicators for disease prognosis and the development of coagulation abnormalities in individuals with asthma. By shedding light on the relationship between immune cell ratios and coagulation markers in the context of asthma, our study contributes to a better understanding of disease progression and the associated complications. These insights can potentially lead to improved management strategies and better outcomes for asthma patients.

Published
2023
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49. A randomized phase II trial of atezolizumab with or without tiragolumab before and after definitive chemoradiation for unresectable stage III non-small cell lung cancer (NSCLC; AFT-57).

Author

Ross, Helen J., primary, Kozono, David E., additional, Mix, Michael D, additional, Urbanic, James John, additional, Williams, Terence Marques, additional, O'Donnell, Taylor, additional, Bara, Ilze, additional, Schulze, Katja, additional, Wang, Xiaofei F., additional, Nelson, Garth D., additional, and Stinchcombe, Tom, additional

Published
2024
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