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This article analyses a narrative pattern in Tacitus’ Agricola dealing with the crossing of natural boundaries. First it discusses imaginary geography and the connections between the bounds of nature and the psychology of Agricola and his soldiers. It then turns to a discus- sion of paradoxes inherent in how the bounds of nature are handled, and discusses several traditions on which Tacitus draws. In declama- tion the edges of the earth represent a mystery and a danger, while the philosophical topos of the flight of the mind, as exemplified by Lucretius’ praises of Epicurus, offers a positive scheme in which breaking the bounds of nature is a metaphor for major intellectual achievement. The implications of Agricola’s identity as a provincial Roman are discussed, along with the glimpses of an imaginary geog- raphy in which Rome is de-centred. Finally the article considers how Tacitus inverts a literary tradition of associating the periphery of the earth with death and the underworld.

Dieser Beitrag erläutert, wie die im Teilprojekt entstandenen Selbstlernangebote (Schreibberatung, Vortragscoaching, Sprachtutorien) über die Laufzeit des Teilprojekts (weiter-)entwickelt wurden und wie Studierende durch die Einführung von neuen, flexibleren Lernformaten (z. B. Einzelberatungen) unterstützt werden. Zudem wird aufgezeigt, wie sich wissenschaftlichen Hilfskräften die Möglichkeit bietet, sich als Schreibberater/ in, Vortragscoach oder Sprachtutor/in weiterzubilden. Somit wird an der Universität Potsdam nicht nur das Selbstlernen, sondern auch Peer Learning gefördert.

INTRODUCTION: Diabetes Mellitus (DM) is a chronic condition associated with abnormally high levels of sugar (glucose) in the blood. The management of diabetes mellitus (DM) largely depends on patients’ ability to self-care in their daily lives, and therefore, patient education is always considered an essential element of DM management. Patient counselling involves providing drug information, dietary and lifestyle modifications. Thus patient counselling plays a major role in increasing patient’s medication adherence and improving the patient’s quality of life. The current study is to study the effect of counselling on Knowledge, attitude and Practice among type 2 Diabetes mellitus. MATERIALS AND METHODS: A prospective observational study was carried out over a period of six months in General Medicine Department Of Muthoot Healthcare, Pvt. Ltd, Kozhencherry. The type 2 diabetic patients who were on oral hypoglycemic were enrolled in the study. A suitable data collection form was prepared and used to collect the required data. The demographic data, disease data and the utilization of various oral antidiabetic agents were analyzedand the knowledge of the patients was assessed by using a Knowledge,Attitude and Practice questionnaire. For this study 398 subjects were enrolled based on the inclusion and exclusion criteria. RESULTS: Among 398 subject, 89.5% shows elevated FBS before counselling and this is decreased to 53.5% after counseling, mean value of Pre-test (Before counselling) and Post-test(After counselling) was 35 and 16.4 respectively. In our study it was found that counseling was effective in maintaining glycemic control.

Analyses the doctoral research undertaken by scholars in MG University during the first twenty-five years of its existence (1983 to 2008). Finds that University has produced doctorates in highly relevant and emerging areas of science like biotechnology, genetic engineering, biodiversity studies and environmental conservation and that a few guides supervised research in very specific areas and the research by them as well as by their students form the highly cited Indian works worldwide like in Polymer. The rise and fall in the curve on number of scholars enrolling for research at a time is found related to the implementation of UGC Schemes and their periodical revisions. Research in science and arts subjects reveals slow and steady growth with very little fluctuation in scientific research, and steep fluctuations in arts and social science. Literary studies, Chemical Science, Polymer, Rubber and Cancer are found to be the strong areas of MGU research. The geographical region covered by the university is a major rubber-producing region in India and the works on rubber reveal that university has taken care of the research and development needs of the region. Opines that university has made remarkable contribution to knowledge during the last two and half decades.

Introduction/ Purpose of study Targeting M2 macrophages as an immunosuppressive cell population within the tumor-microenvironment has become an important effort within preclinical research to achieve and enhance anti-tumor efficacy. In contrast to reprogramming approaches, we focused on effective and specific depletion of M2 macrophages (Mphs) by a new antibody-drug-conjugate (ADC) comprising a CD206-binding antibody conjugated to a nicotinamide phosphoribosyl transferase (NAMPT) toxophore which was proved to be very potent in cell killing. Description of procedures Human (hu) and mouse (ms) cross-reactive CD206 antibodies were identified by phage display using recombinant hu/ms CD206-extracellular domains. Selected clones showing strong CD206 binding by ELISA were reformatted into huIgG1 format and cellular targeting confirmed by FACS binding and internalization using CD206-transfected HEK cells. Antibodies were conjugated to a NAMPT toxophore by Cys-conjugation using two different non-cleavable linkers. Murine peritoneal Mphs collected after thioglycolate stimulation were polarized to M1 (LPS + IFNγ) or M2 (IL4 + IL13 + PGE2) within 24h and characterized for cytokines and typical markers via FACS (CD206, CD163, CD80/MHCII) and qPCR (iNOS, TGFβ, ARG1). After 96h treatment with either CD206- or isotype-NAMPT-ADCs, viability of Mphs was determined. In vivo pharmacokinetics (PK) of unconjugated antibodies were analyzed in plasma of female BALB/c mice for up to 72h. Summary of data Of the resulting 57 hu/ms cross-reactive CD206-binding antibodies, TPP-17829 and TPP-17836 were identified with single-digit nanomolar binding affinity and strong internalization in CD206-transfected cells as a prerequisite for an ADC approach. Conjugation of the antibodies to NAMPT toxophores yielded drug-antibody-ratios of 4-7 as determined by SEC-UV without significant aggregation. These two CD206-NAMPT-ADCs successfully depleted polarized M2-Mphs characterized by high CD206 expression, whereas isotype-NAMPT-ADC controls had no effect. While the unconjugated NAMPT toxophore was potent in depleting primary low-proliferating M1/M2 Mphs, by comparison, the anti-proliferative toxophore KSP (kinesin-spindle-protein inhibitor) was completely ineffective. PK analysis of TPP-17829 and TPP-17836, however, revealed a rapid plasma clearance within the first hours, most likely target-mediated via the liver, rendering them unacceptable for in vivo efficacy testing as NAMPT-ADCs. Conclusions CD206-NAMPT-ADCs demonstrated proof of concept for specific depletion of M2-Mphs in vitro. However, specific in vivo depletion of M2 Mphs from tumors will be challenging with respect to fast plasma clearance observed for anti-CD206 antibodies. Citation Format: Sandra Berndt, Katharina Filarsky, Patrick Smith, Niels Boehnke, Markus Berger, Fionnuala McAleese Eser, Hans-Georg Lerchen, Phillip Ellinger, Mathias Gehrmann, Jim Wu, Dominic Hildebrand, Bertolt Kreft, Uwe Gritzan. Effective depletion of M2 macrophages by CD206-NAMPT-ADCs [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 677.

We present three-dimensional (3-D) models that describe the present-day thermal and rheological state of the lithosphere of the greater Kenya rift region aiming at a better understanding of the rift evolution, with a particular focus on plume-lithosphere interactions. The key methodology applied is the 3-D integration of diverse geological and geophysical observations using gravity modelling. Accordingly, the resulting lithospheric-scale 3-D density model is consistent with (i) reviewed descriptions of lithological variations in the sedimentary and volcanic cover, (ii) known trends in crust and mantle seismic velocities as revealed by seismic and seismological data and (iii) the observed gravity field. This data-based model is the first to image a 3-D density configuration of the crystalline crust for the entire region of Kenya and northern Tanzania. An upper and a basal crustal layer are differentiated, each composed of several domains of different average densities. We interpret these domains to trace back to the Precambrian terrane amalgamation associated with the East African Orogeny and to magmatic processes during Mesozoic and Cenozoic rifting phases. In combination with seismic velocities, the densities of these crustal domains indicate compositional differences. The derived lithological trends have been used to parameterise steady-state thermal and rheological models. These models indicate that crustal and mantle temperatures decrease from the Kenya rift in the west to eastern Kenya, while the integrated strength of the lithosphere increases. Thereby, the detailed strength configuration appears strongly controlled by the complex inherited crustal structure, which may have been decisive for the onset, localisation and propagation of rifting.

KNOWLEDGE AND ATTITUDES TOWARDS APHASIAIntroductionAphasia is a communication disorder thatu2019s caused by damage or injury to the brain, most commonly from a stroke. Aphasia affects a personu2019s ability to use language; understanding, speaking, reading and/or writing. The aim of the study was to establish whether participantsu2019 knowledge and attitudes (KAA) towards aphasia were different after watching an educational video describing the impact of aphasia on stroke survivors.MethodAn aphasia friendly KAA questionnaire was designed and disseminated amongst the public attending a Stroke Symposium (November 2018). A quantitative, descriptive design was chosen to objectively measure, describe and document KAA towards aphasia after watching the video. Fourteen questions pertaining to the KAA towards aphasia were generated in line with the constructs of the Capability, Opportunity and Motivation Behavioural (COM-B) model and Theoretical Domains Framework (TDF).ResultsData were collected, collated and entered into SPSS. A 90% (n=90) response rate was achieved. Participants included nine (10%) stroke survivors, 12 (13.3%) family member or carer of stroke survivors and 69 (76.6%) others, comprising academics, researchers, students and members of the public. A reliability analysis was conducted to determine the level of internal consistency for the attitude statements. All alpha coefficients were above 0.7 (alpha=0.933) indicating good internal consistency of the scale.ConclusionThe results highlight that this is a reliable questionnaire, with an aphasia friendly approach, which can be used in practice. The questionnaire will now be amended to create pre and post questionnaires to understand changes in peopleu2019s KAA towards aphasia in future stroke symposiums and educational workshops.