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1. Demographics of sources of HIV-1 transmission in Zambia: a molecular epidemiology analysis in the HPTN 071 PopART study

Author

Agyei, Yaw, Beyers, Nulda, Bock, Peter, Bond, Virginia, Bwalya, Justin, Cori, Anne, Deventer, Anneen, Dunbar, Rory, El-Sadr, Wafaa, Emel, Lynda, Floyd, Sian, Griffith, Sam, Hargreaves, James, Hauck, Katharina, Headen, Tanette, Hoddinott, Graeme, James, Anelet, Jennings, Karen, Kanema, Sarah, Kosloff, Barry, Kruger, James, Kumar, Ramya, Macleod, David, Makola, Nozizwe, Mandla, Nomtha, Miller, Eric, Moore, Ayana, Mwenge, Lawrence, Noble, Heather, Phiri, Mwelwa, Pickles, Michael, Sabapathy, Kalpana, Sakala, Ephraim, Sauter, Rafael, Shanaube, Kwame, Silumesi, Andrew, Sista, Nirupama, Skalland, Tim, Smith, Peter, Thomas, Ranjeeta, Vermund, Sten, White, Rhonda, Wilson, Ethan, Yang, Blia, Yuhas, Krista, Bowden, Rory, Calvez, Vincent, Essex, Max, Grabowski, Kate, Gupta, Ravindra, Herbeck, Joshua, Kagaayi, Joseph, Kaleebu, Pontiano, Lingappa, Jairam, Moyo, Sikhulile, Novitsky, Vladimir, Ndung’u, Thumbi, Pillay, Deenan, Quinn, Thomas, Rambaut, Andrew, Seeley, Janet, Ssemwanga, Deogratius, Tanser, Frank, Wawer, Maria, Hall, Matthew, Golubchik, Tanya, Bonsall, David, Abeler-Dörner, Lucie, Limbada, Mohammed, Schaap, Ab, de Cesare, Mariateresa, MacIntyre-Cockett, George, Otecko, Newton, Probert, William, Ratmann, Oliver, Bulas Cruz, Ana, Piwowar-Manning, Estelle, Burns, David N, Cohen, Myron S, Donnell, Deborah J, Eshleman, Susan H, Simwinga, Musonda, Fidler, Sarah, Hayes, Richard, Ayles, Helen, and Fraser, Christophe

Published
2024
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2. Projected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study

Author

Hayes, Richard, Fidler, Sarah, Beyers, Nulda, Ayles, Helen, Bock, Peter, El-Sadr, Wafaa, Cohen, Myron, Eshleman, Susan, Agyei, Yaw, Piwowar-Manning, Estelle, Bond, Virginia, Hoddinott, Graeme, Donnell, Deborah, Floyd, Sian, Wilson, Ethan, Emel, Lynda, Noble, Heather, Macleod, David, Burns, David, Fraser, Christophe, Cori, Anne, Sista, Nirupama, Griffith, Sam, Moore, Ayana, Headen, Tanette, White, Rhonda, Miller, Eric, Hargreaves, James, Hauck, Katharina, Thomas, Ranjeeta, Limbada, Mohammed, Bwalya, Justin, Pickles, Michael, Sabapathy, Kalpana, Schaap, Ab, Dunbar, Rory, Shanaube, Kwame, Yang, Blia, Simwinga, Musonda, Smith, Peter, Vermund, Sten, Mandla, Nomtha, Makola, Nozizwe, van Deventer, Anneen, James, Anelet, Jennings, Karen, Kruger, James, Phiri, Mwelwa, Kosloff, Barry, Mwenge, Lawrence, Kanema, Sarah, Sauter, Rafael, Probert, William, Kumar, Ramya, Sakala, Ephraim, Silumesi, Andrew, Skalland, Tim, Yuhas, Krista, Probert, William J M, Bell-Mandla, Nomtha F, Abeler-Dörner, Lucie, Donnell, Deborah J, Skalland, Timothy, and Hayes, Richard J

Published
2022
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3. Validation of population-level HIV-1 incidence estimation by cross-sectional incidence assays in the HPTN 071 (PopART) trial

Author

Klock, Ethan, Wilson, Ethan, Fernandez, Reinaldo E., Piwowar-Manning, Estelle, Moore, Ayana, Kosloff, Barry, Bwalya, Justin, Bell-Mandla, Nomtha, James, Anelet, Ayles, Helen, Bock, Peter, Donnell, Deborah, Fidler, Sarah, Hayes, Richard, Eshleman, Susan H., and Laeyendecker, Oliver

Subjects
Statistics, Drug therapy, Usage, Risk factors, Algorithm, Clinical trials -- Statistics, Algorithms -- Usage, HIV infections -- Statistics -- Risk factors -- Drug therapy, Biochemical assays -- Usage, HIV infection -- Statistics -- Risk factors -- Drug therapy
Abstract

1 | INTRODUCTION HIV incidence is the rate of new HIV infections in a population and the primary measure in evaluating the state of the epidemic and the effectiveness of [...], Introduction: Cross-sectional incidence testing is used to estimate population-level HIV incidence and measure the impact of prevention interventions. There are limited data evaluating the accuracy of estimates in settings where antiretroviral therapy coverage and levels of viral suppression are high. Understanding cross-sectional incidence estimates in these settings is important as viral suppression can lead to false recent test results. We compared the accuracy of multi-assay algorithms (MAA) for incidence estimation to that observed in the community-randomized HPTN 071 (PopART) trial, where the majority of participants with HIV infection were virally suppressed. Methods: HIV incidence was assessed during the second year of the study, and included only individuals who were tested for HIV at visits 1 and 2 years after the start of the study (2016-2017). Incidence estimates from three MAAs were compared to the observed incidence between years 1 and 2 (MAA-C: LAg-Avidity 400 copies/ml; LAg+VL MAA: LAg-Avidity 1000 copies/ml; Rapid+VL MAA: Asante recent rapid result + VL >1000 copies/ml). The mean duration of recent infection (MDRI) used for the three MAAs was 248, 130 and 180 days, respectively. Results and discussion: The study consisted of: 15,845 HIV-negative individuals; 4406 HIV positive at both visits; and 221 who seroconverted between visits. Viral load (VL) data were available for all HIV-positive participants at the 2-year visit. Sixty four (29%) of the seroconverters and 3227 (72%) prevelant positive participants were virally supressed ( Conclusions: MAA-C and the LAg+VL MAA provided accurate point estimates of incidence in this cohort with high levels of viral suppression. The Rapid+VL significantly underestimated incidence, suggesting that the MDRI recommended by the manufacturer is too long or the assay is not accurately detecting enough recent infections. Keywords: validation study; cross-sectional incidence estimation; sub-Saharan Africa; HPTN; PopART; multi-assay algorithm

Published
2021
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4. Demographics of sources of HIV-1 transmission in Zambia: a molecular epidemiology analysis in the HPTN 071 PopART study

Author

Hall, Matthew, primary, Golubchik, Tanya, additional, Bonsall, David, additional, Abeler-Dörner, Lucie, additional, Limbada, Mohammed, additional, Kosloff, Barry, additional, Schaap, Ab, additional, de Cesare, Mariateresa, additional, MacIntyre-Cockett, George, additional, Otecko, Newton, additional, Probert, William, additional, Ratmann, Oliver, additional, Bulas Cruz, Ana, additional, Piwowar-Manning, Estelle, additional, Burns, David N, additional, Cohen, Myron S, additional, Donnell, Deborah J, additional, Eshleman, Susan H, additional, Simwinga, Musonda, additional, Fidler, Sarah, additional, Hayes, Richard, additional, Ayles, Helen, additional, Fraser, Christophe, additional, Agyei, Yaw, additional, Beyers, Nulda, additional, Bock, Peter, additional, Bond, Virginia, additional, Bwalya, Justin, additional, Cori, Anne, additional, Deventer, Anneen, additional, Dunbar, Rory, additional, El-Sadr, Wafaa, additional, Emel, Lynda, additional, Floyd, Sian, additional, Griffith, Sam, additional, Hargreaves, James, additional, Hauck, Katharina, additional, Headen, Tanette, additional, Hoddinott, Graeme, additional, James, Anelet, additional, Jennings, Karen, additional, Kanema, Sarah, additional, Kruger, James, additional, Kumar, Ramya, additional, Macleod, David, additional, Makola, Nozizwe, additional, Mandla, Nomtha, additional, Miller, Eric, additional, Moore, Ayana, additional, Mwenge, Lawrence, additional, Noble, Heather, additional, Phiri, Mwelwa, additional, Pickles, Michael, additional, Sabapathy, Kalpana, additional, Sakala, Ephraim, additional, Sauter, Rafael, additional, Shanaube, Kwame, additional, Silumesi, Andrew, additional, Sista, Nirupama, additional, Skalland, Tim, additional, Smith, Peter, additional, Thomas, Ranjeeta, additional, Vermund, Sten, additional, White, Rhonda, additional, Wilson, Ethan, additional, Yang, Blia, additional, Yuhas, Krista, additional, Bowden, Rory, additional, Calvez, Vincent, additional, Essex, Max, additional, Grabowski, Kate, additional, Gupta, Ravindra, additional, Herbeck, Joshua, additional, Kagaayi, Joseph, additional, Kaleebu, Pontiano, additional, Lingappa, Jairam, additional, Moyo, Sikhulile, additional, Novitsky, Vladimir, additional, Ndung’u, Thumbi, additional, Pillay, Deenan, additional, Quinn, Thomas, additional, Rambaut, Andrew, additional, Seeley, Janet, additional, Ssemwanga, Deogratius, additional, Tanser, Frank, additional, and Wawer, Maria, additional

Published
2023
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5. Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial

Author

Hargreaves, James, Watson-Jones, Deborah, Godfrey-Faussett, Peter, Cori, Anne, Pickles, Mike, Mandla, Nomtha, Yang, Blia, James, Anelet, Vermaak, Redwaan, Makola, Nozizwe, Hoddinott, Graeme, Naidoo, Vikesh, Bond, Virginia, Simwinga, Musonda, Mwinga, Alwyn, Kosloff, Barry, Limbada, Mohammed, Bwalya, Justin, Ngulube, Chepela, Fraser, Christophe, Eshleman, Susan, Agyei, Yaw, Cummings, Vanessa, Catalano, Denni, Emel, Lynda, Bunts, Lisa, Noble, Heather, Burns, David, Kouda, Alain, Sista, Niru, Moore, Ayana, White, Rhonda, Headen, Tanette, Miller, Eric, Hinson, Kathy, Vermund, Sten, Barnes, Mark, Horn, Lyn, Mwango, Albert, Baldwin, Megan, Wolf, Shauna, Hughes, Erin, Thomas, Ranjeeta, Burger, Ronelle, Harper, Abigail, Kanema, Sarah, Mwenge, Lawrence, Vanqa, Nosivuyile, Bell-Mandla, Nomtha, Smith, Peter C, Floyd, Sian, Bock, Peter, Ayles, Helen, Beyers, Nulda, Donnell, Deborah, Fidler, Sarah, Hayes, Richard, and Hauck, Katharina

Published
2017
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6. Understanding low sensitivity of community-based HIV rapid testing: experiences from the HPTN 071 (PopART) trial in Zambia and South Africa

Author

Bock, Peter, Phiri, Comfort, Manning, Estelle Piwowar, Kosloff, Barry, Mandla, Nomtha, Young, Alicia, James, Anelet, Schaap, A.B., Scheepers, Michelle, Donnell, Deborah, Griffith, Sam, Sadr, Wafaa El, Shanaube, Kwame, Beyers, Nulda, Hayes, Richard, Fidler, Sarah, and Ayles, Helen

Subjects
Diagnosis, Care and treatment, Analysis, Usage, Research, Dosage and administration, Health aspects, Quality control, Quality control -- Analysis, HIV tests -- Usage -- Health aspects, HIV -- Research -- Diagnosis -- Care and treatment, Antiretroviral agents -- Research -- Dosage and administration
Abstract

Introduction: Population-wide HIV testing services (HTS) must be delivered in order to achieve universal antiretroviral treatment (ART) coverage. To accurately deliver HTS at such scale, non-facility-based HIV point-of-care testing (HIV-POCT) [...]

Published
2017
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7. Projected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study

Author

Probert, William J M, primary, Sauter, Rafael, additional, Pickles, Michael, additional, Cori, Anne, additional, Bell-Mandla, Nomtha F, additional, Bwalya, Justin, additional, Abeler-Dörner, Lucie, additional, Bock, Peter, additional, Donnell, Deborah J, additional, Floyd, Sian, additional, Macleod, David, additional, Piwowar-Manning, Estelle, additional, Skalland, Timothy, additional, Shanaube, Kwame, additional, Wilson, Ethan, additional, Yang, Blia, additional, Ayles, Helen, additional, Fidler, Sarah, additional, Hayes, Richard J, additional, Fraser, Christophe, additional, Hayes, Richard, additional, Beyers, Nulda, additional, El-Sadr, Wafaa, additional, Cohen, Myron, additional, Eshleman, Susan, additional, Agyei, Yaw, additional, Bond, Virginia, additional, Hoddinott, Graeme, additional, Donnell, Deborah, additional, Emel, Lynda, additional, Noble, Heather, additional, Burns, David, additional, Sista, Nirupama, additional, Griffith, Sam, additional, Moore, Ayana, additional, Headen, Tanette, additional, White, Rhonda, additional, Miller, Eric, additional, Hargreaves, James, additional, Hauck, Katharina, additional, Thomas, Ranjeeta, additional, Limbada, Mohammed, additional, Sabapathy, Kalpana, additional, Schaap, Ab, additional, Dunbar, Rory, additional, Simwinga, Musonda, additional, Smith, Peter, additional, Vermund, Sten, additional, Mandla, Nomtha, additional, Makola, Nozizwe, additional, van Deventer, Anneen, additional, James, Anelet, additional, Jennings, Karen, additional, Kruger, James, additional, Phiri, Mwelwa, additional, Kosloff, Barry, additional, Mwenge, Lawrence, additional, Kanema, Sarah, additional, Probert, William, additional, Kumar, Ramya, additional, Sakala, Ephraim, additional, Silumesi, Andrew, additional, Skalland, Tim, additional, and Yuhas, Krista, additional

Published
2022
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8. Effect of household and community interventions on the burden of tuberculosis in southern Africa: the ZAMSTAR community-randomised trial

Author

Ayles, Helen, Muyoyeta, Monde, Du Toit, Elizabeth, Schaap, Ab, Floyd, Sian, Simwinga, Musonda, Shanaube, Kwame, Chishinga, Nathaniel, Bond, Virginia, Dunbar, Rory, De Haas, Petra, James, Anelet, van Pittius, Nico C Gey, Claassens, Mareli, Fielding, Katherine, Fenty, Justin, Sismanidis, Charalampos, Hayes, Richard J, Beyers, Nulda, and Godfrey-Faussett, Peter

Published
2013
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9. Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART)

Author

Hayes, Richard J., primary, Donnell, Deborah, additional, Floyd, Sian, additional, Mandla, Nomtha, additional, Bwalya, Justin, additional, Sabapathy, Kalpana, additional, Yang, Blia, additional, Phiri, Mwelwa, additional, Schaap, Ab, additional, Eshleman, Susan H., additional, Piwowar-Manning, Estelle, additional, Kosloff, Barry, additional, James, Anelet, additional, Skalland, Timothy, additional, Wilson, Ethan, additional, Emel, Lynda, additional, Macleod, David, additional, Dunbar, Rory, additional, Simwinga, Musonda, additional, Makola, Nozizwe, additional, Bond, Virginia, additional, Hoddinott, Graeme, additional, Moore, Ayana, additional, Griffith, Sam, additional, Deshmane Sista, Nirupama, additional, Vermund, Sten H., additional, El-Sadr, Wafaa, additional, Burns, David N., additional, Hargreaves, James R., additional, Hauck, Katharina, additional, Fraser, Christophe, additional, Shanaube, Kwame, additional, Bock, Peter, additional, Beyers, Nulda, additional, Ayles, Helen, additional, and Fidler, Sarah, additional

Published
2019
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11. Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial

Author

Thomas, Ranjeeta, primary, Burger, Ronelle, additional, Harper, Abigail, additional, Kanema, Sarah, additional, Mwenge, Lawrence, additional, Vanqa, Nosivuyile, additional, Bell-Mandla, Nomtha, additional, Smith, Peter C, additional, Floyd, Sian, additional, Bock, Peter, additional, Ayles, Helen, additional, Beyers, Nulda, additional, Donnell, Deborah, additional, Fidler, Sarah, additional, Hayes, Richard, additional, Hauck, Katharina, additional, Hargreaves, James, additional, Watson-Jones, Deborah, additional, Godfrey-Faussett, Peter, additional, Cori, Anne, additional, Pickles, Mike, additional, Mandla, Nomtha, additional, Yang, Blia, additional, James, Anelet, additional, Vermaak, Redwaan, additional, Makola, Nozizwe, additional, Hoddinott, Graeme, additional, Naidoo, Vikesh, additional, Bond, Virginia, additional, Simwinga, Musonda, additional, Mwinga, Alwyn, additional, Kosloff, Barry, additional, Limbada, Mohammed, additional, Bwalya, Justin, additional, Ngulube, Chepela, additional, Fraser, Christophe, additional, Eshleman, Susan, additional, Agyei, Yaw, additional, Cummings, Vanessa, additional, Catalano, Denni, additional, Emel, Lynda, additional, Bunts, Lisa, additional, Noble, Heather, additional, Burns, David, additional, Kouda, Alain, additional, Sista, Niru, additional, Moore, Ayana, additional, White, Rhonda, additional, Headen, Tanette, additional, Miller, Eric, additional, Hinson, Kathy, additional, Vermund, Sten, additional, Barnes, Mark, additional, Horn, Lyn, additional, Mwango, Albert, additional, Baldwin, Megan, additional, Wolf, Shauna, additional, and Hughes, Erin, additional

Published
2017
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12. Erratum to: Precision of the Kalon Herpes Simplex Virus Type 2 IgG ELISA: an international inter-laboratory assessment

Author

Patel, Eshan U., primary, Manucci, Jordyn, additional, Kahle, Erin M., additional, Lingappa, Jairam R., additional, Morrow, Rhoda Ashley, additional, Piwowar-Manning, Estelle, additional, James, Anelet, additional, Maluzi, Kwitaka F., additional, Cheeba, Maina M., additional, Gray, Glenda, additional, Kosloff, Barry, additional, Delany-Moretlwe, Sinead, additional, Inambao, Mubiana, additional, Vwalika, Bellington, additional, Quinn, Thomas C., additional, and Laeyendecker, Oliver, additional

Published
2017
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14. Precision of the Kalon Herpes Simplex Virus Type 2 IgG ELISA: an international inter-laboratory assessment

Author

Patel, Eshan U., primary, Manucci, Jordyn, additional, Kahle, Erin M., additional, Lingappa, Jairam R., additional, Morrow, Rhoda Ashley, additional, Piwowar-Manning, Estelle, additional, James, Anelet, additional, Maluzi, Kwitaka F., additional, Cheeba, Maina M., additional, Gray, Glenda, additional, Delany-Moretlwe, Sinead, additional, Inambao, Mubiana, additional, Vwalika, Bellington, additional, Quinn, Thomas C., additional, and Laeyendecker, Oliver, additional

Published
2015
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