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Your search keyword '"Jamal M, Zekri"' showing total 2 results
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2 results on '"Jamal M, Zekri"'

1. Relative Hypocalcaemia and Muscle Cramps in Patients Receiving Imatinib for Gastrointestinal Stromal Tumour

Author

Jamal M. Zekri, Martin H. Robinson, and Penella J. Woll

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Purpose. Imatinib treatment causes muscle cramps in up to 40% of patients, but their pathogenesis is unknown. We present a case series illustrating an association between imatinib, relative hypocalcaemia, and the development of cramps. Patients. The index patient developed muscle spasms and cramps after receiving imatinib for gastrointestinal stromal tumour (GIST) for 5 months. The adjusted serum calcium had dropped to the lower limit of normal. The low serum calcium and muscle cramps improved on stopping imatinib and recurred on rechallenge. We reviewed the medical records of 16 further patients. Results. Two patients reported muscle cramps (12%). There was a rapid and sustained reduction in adjusted serum calcium in the first 6 months from 2.45 ± 0.11 mmol/L (mean ± SD) to 2.30 ± 0.08 mmol/L (p=0.025). Conclusion. Imatinib treatment of GIST is associated with reduction in serum calcium which may explain the development of neuromuscular symptoms. In patients receiving imatinib, serum electrolytes should be monitored and muscle cramps treated by correction of serum calcium, or an empirical trial of quinine sulphate.

Published
2006
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2. Prognostic value of lymph node ratio in poor prognosis node-positive breast cancer patients in Saudi Arabia

Author

Ezzeldin M, Ibrahim, Tawfik R, Elkhodary, Jamal M, Zekri, Yasir, Bahadur, Mohamed E, El-Sayed, Aboelkhair M, Al-Gahmi, Syed Azhar J, Rizvi, Ashraf H, Hassouna, Ehab E, Fawzy, and Said S, Awadalla

Subjects
Adult, Aged, 80 and over, Saudi Arabia, Breast Neoplasms, Middle Aged, Prognosis, Survival Analysis, Disease-Free Survival, Young Adult, Treatment Outcome, Humans, Lymph Node Excision, Female, Lymph Nodes, Aged, Retrospective Studies
Abstract

Women in Saudi Arabia develop breast cancer at a young age with high prevalence of poor prognostic features. Because of such features, it is necessary to examine prognostic factors in this population. One such factor is the prognostic role of lymph node ratio (LNR).We performed retrospective analyses of patients with invasive non-metastatic breast cancer who underwent axillary lymph node dissection and had one or more positive axillary lymph nodes.Two hundred and seventeen patients were considered eligible for the analysis. The median age was 46 years. At a median follow-up of 39.8 months, the median disease-free survival (DFS) was 67.3 months (95% CI, 50.4 to 84.3 months). Neither the classification of patients based on positive lymph node (pN) staging system, nor the absolute number of pN prognosticated DFS. Conversely, ageor= 35 years at diagnosis, grade 3 tumors and the intermediate (0.20 toor=0.65) and high (0.65) LNR categories were the only variables that were independently associated with adverse DFS. Using these variables in a prognostic model allowed the classification of patients into three distinctive risk strata. The overall survival (OS) in this series was 92.5 months (95% CI, 92.1-92.6). Only ER negative tumor adversely influenced OS.Analysis of survival outcome of mostly young patients with early breast cancer identified adverse prognostic variables affecting DFS. If the utility of the derived model including LNR is proven in a larger patient population, it may replace the use of absolute number of positive axillary lymph nodes.

Published
2010

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