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Introduction: To design and validate a scale of perception of teleworking in Peruvian primary schoolteachers., Method: This was a cross-sectional study of 400 primary schoolteachers (61.5% women) between 21 and 61 years of age, from six cities in Peru. Eight items were proposed, corresponding to indicators of training, safety, and flexibility of schedules, derived from the scientific literature. The scale was validated by seven experts who evaluated the relevance, representativeness and clarity of the items. Subsequently, we applied exploratory f (EFA) and confirmatory factor analysis (CFA), using the FACTOR Analysis program and SPSS AMOS version 21., Results: The Aiken V indicators were statistically significant for the eight items. Before running the AFE, we calculated the KMO coefficient (0.93) and Bartlett's test (1832.9; gl = 28; p = 0.00). A single factor explained 62.27% of the total variance of the scale and its factor loadings ranged from 0.65 to 0.84. The CFA corroborated the internal structure of the scale (?2 = 58.24, df = 20, p < 0.01; RMR = 0.03; TLI = 0.97; CFI = 0.97; and RMSEA = 0.06) and the reliability was acceptable (? = 0.93; 95% CI = 0.89 - 0.92)., Conclusions: The scale demonstrates evidence of content-based validity, internal structure and reliability.

Ibuprofen micronization with dry coating is investigated to examine its influence on passivation/stabilization of high-surface-energy sites and reduced cohesion. A fluid energy mill was used to micronize ibuprofen particles down to 5-28 μm with or without simultaneous nanosilica coating. Powder flow property and dispersibility were characterized using FT4 powder tester and Rodos/Helos laser diffraction particle sizer. Surface energy was characterized using a next generation inverse gas chromatography instrument. Uncoated micronized ibuprofen showed an increased Lifshitz-van der Waals (LW) dispersion component of surface energy with increasing milling intensity. In contrast, dry-coated milled powders showed a significant reduction in the LW component, whereas physical mixture of uncoated micronized ibuprofen and silica exhibited no reduction in surface energy, indicating that dry coating is necessary for the passivation of high-energy sites of ibuprofen created during micronization. Surface energy of pure micronized ibuprofen was highly heterogeneous, whereas dry-coated ibuprofen had greatly reduced heterogeneity. Micronization with dry coating also improved flowability and bulk density as compared with pure active pharmaceutical ingredient micronization without coating, or just blending with silica. Overall, dry coating leads to decreased cohesion and improved flowability because of reduced LW dispersive component of surface energy and creating nanoscale surface roughness., (Copyright © 2013 Wiley Periodicals, Inc.)