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1. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing

Author

Quinn, TA, Granite, S, Allessie, MA, Antzelevitch, C, Bollensdorff, C, Bub, G, Burton, RAB, Cerbai, E, Chen, PS, Delmar, M, DiFrancesco, D, Earm, YE, Efimov, IR, Egger, M, Entcheva, E, Fink, M, Fischmeister, R, Franz, MR, Garny, A, Giles, WR, Hannes, T, Harding, SE, Hunter, PJ, Iribe, G, Jalife, J, Johnson, CR, Kass, RS, Kodama, I, Koren, G, Lord, P, Markhasin, VS, Matsuoka, S, McCulloch, AD, Mirams, GR, Morley, GE, Nattel, S, Noble, D, Olesen, SP, Panfilov, AV, Trayanova, NA, Ravens, U, Richard, S, Rosenbaum, DS, Rudy, Y, Sachs, F, Sachse, FB, Saint, DA, Schotten, U, Solovyova, O, Taggart, P, Tung, L, Varró, A, Volders, PG, Wang, K, Weiss, JN, Wettwer, E, White, E, Wilders, R, Winslow, RL, and Kohl, P

Subjects
Heart Disease, Cardiovascular, Animals, Electrophysiological Phenomena, Heart, Humans, Information Dissemination, Models, Biological, Reference Standards, Reproducibility of Results, Research Design, Minimum Information Standard, Cardiac electrophysiology, Data sharing, Reproducibility, Integration, Computational modelling, Biochemistry and Cell Biology, Biophysics
Abstract

Cardiac experimental electrophysiology is in need of a well-defined Minimum Information Standard for recording, annotating, and reporting experimental data. As a step towards establishing this, we present a draft standard, called Minimum Information about a Cardiac Electrophysiology Experiment (MICEE). The ultimate goal is to develop a useful tool for cardiac electrophysiologists which facilitates and improves dissemination of the minimum information necessary for reproduction of cardiac electrophysiology research, allowing for easier comparison and utilisation of findings by others. It is hoped that this will enhance the integration of individual results into experimental, computational, and conceptual models. In its present form, this draft is intended for assessment and development by the research community. We invite the reader to join this effort, and, if deemed productive, implement the Minimum Information about a Cardiac Electrophysiology Experiment standard in their own work.

Published
2011

3. Atrial-specific reduction of Kir2.1 channel pore diameter in addition to loss of inward-going rectification underlies inducible atrial fibrillation in a mouse model of short QT syndrome type 3

Author

Moreno-Manuel, A, primary, Macias, A, additional, Cruz, F M, additional, Gutierrez, L, additional, Martinez Carrascoso, I, additional, Bermudez-Jimenez, F J, additional, Vera-Pedrosa, M L, additional, Sanchez-Perez, P, additional, Bernal, J, additional, and Jalife, J, additional

Published
2022
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10. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, Yamane, T, and Document Reviewers

Published
2018

13. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

Author

Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina K.), Cosedis Nielsen, J. (Jens), Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), D'Avila, A. (Andr'E), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), MacLe, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R.), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), Yamane, T. (Teiichi), Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina K.), Cosedis Nielsen, J. (Jens), Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), D'Avila, A. (Andr'E), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), MacLe, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R.), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), and Yamane, T. (Teiichi)

Published
2018
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14. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

Author

Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina K.), Cosedis Nielsen, J. (Jens), Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), D'Avila, A. (Andr'E), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), MacLe, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R.), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), Yamane, T. (Teiichi), Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina K.), Cosedis Nielsen, J. (Jens), Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), D'Avila, A. (Andr'E), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), MacLe, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R.), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), and Yamane, T. (Teiichi)

Published
2018
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15. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, Yamane, T, Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, and Yamane, T

Published
2018

16. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

Author

Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina), Nielsen, J.C., Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), d'Avila, A. (André), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), Macle, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), Yamane, T. (Teiichi), Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina), Nielsen, J.C., Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), d'Avila, A. (André), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), Macle, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), and Yamane, T. (Teiichi)

Published
2017
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17. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

Author

Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina), Nielsen, J.C., Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), d'Avila, A. (André), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), Macle, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), Yamane, T. (Teiichi), Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina), Nielsen, J.C., Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), d'Avila, A. (André), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), Macle, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), and Yamane, T. (Teiichi)

Published
2017
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18. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, W, Day, JD, d'Avila, A, De Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, Yamane, T, Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, W, Day, JD, d'Avila, A, De Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, and Yamane, T

Published
2017

19. 2017HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, Yamane, T, Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, and Yamane, T

Published
2017

20. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, Yamane, T, Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, and Yamane, T

Published
2017

22. P5836A mutation in the gene encoding the tbx5 transcription factor is associated with the Brugada Syndrome

Author

Caballero, R., primary, Alfayate, S., additional, Utrilla, R.G., additional, Nieto-Marin, P., additional, Tinaquero, D., additional, Perez-Hernandez, M., additional, Matamoros, M., additional, Herron, T.J., additional, Campbell, K., additional, Lopez-Sendon, J.L., additional, Peinado, R., additional, Jalife, J., additional, Tamargo, J., additional, and Delpon, E., additional

Published
2017
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23. EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication

Author

Goette, A, Kalman, JM, Aguinaga, L, Akar, J, Angel Cabrera, J, Chen, SA, Chugh, SS, Corradi, D, D'Avila, A, Dobrev, D, Fenelon, G, Gonzalez, M, Hatem, SN, Helm, R, Hindricks, G, Ho, SY, Hoit, B, Jalife, J, Kim, Y-H, Lip, GYH, Ma, C-S, Marcus, GM, Murray, K, Nogami, A, Sanders, P, Uribe, W, Van Wagoner, DR, Nattel, S, Goette, A, Kalman, JM, Aguinaga, L, Akar, J, Angel Cabrera, J, Chen, SA, Chugh, SS, Corradi, D, D'Avila, A, Dobrev, D, Fenelon, G, Gonzalez, M, Hatem, SN, Helm, R, Hindricks, G, Ho, SY, Hoit, B, Jalife, J, Kim, Y-H, Lip, GYH, Ma, C-S, Marcus, GM, Murray, K, Nogami, A, Sanders, P, Uribe, W, Van Wagoner, DR, and Nattel, S

Published
2016

24. A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene

Author

Priori, S, Pandit, S, Rivolta, I, Berenfeld, O, Ronchetti, E, Dhamoon, A, Napolitano, C, Anumonwo, J, di Barletta, M, Gudapakkam, S, Bosi, G, Stramba Badiale, M, Jalife, J, Priori, SG, Pandit, SV, di Barletta, MR, Jalife, J., RIVOLTA, ILARIA, Priori, S, Pandit, S, Rivolta, I, Berenfeld, O, Ronchetti, E, Dhamoon, A, Napolitano, C, Anumonwo, J, di Barletta, M, Gudapakkam, S, Bosi, G, Stramba Badiale, M, Jalife, J, Priori, SG, Pandit, SV, di Barletta, MR, Jalife, J., and RIVOLTA, ILARIA

Abstract

Short QT syndrome (SQTS) leads to an abbreviated QTc interval and predisposes patients to life-threatening arrhythmias. To date, two forms of the disease have been identified: SQT1, caused by a gain of function substitution in the HERG (I(Kr)) channel, and SQT2, caused by a gain of function substitution in the KvLQT1 (I(Ks)) channel. Here we identify a new variant, "SQT3", which has a unique ECG phenotype characterized by asymmetrical T waves, and a defect in the gene coding for the inwardly rectifying Kir2.1 (I(K1)) channel. The affected members of a single family had a G514A substitution in the KCNJ2 gene that resulted in a change from aspartic acid to asparagine at position 172 (D172N). Whole-cell patch-clamp studies of the heterologously expressed human D172N channel demonstrated a larger outward I(K1) than the wild-type (P<0.05) at potentials between -75 mV and -45 mV, with the peak current being shifted in the former with respect to the latter (WT, -75 mV; D172N, -65 mV). Coexpression of WT and mutant channels to mimic the heterozygous condition of the proband yielded an outward current that was intermediate between WT and D172N. In computer simulations using a human ventricular myocyte model the increased outward I(K1) greatly accelerated the final phase of repolarization, and shortened the action potential duration. Hence, unlike the known mutations in the two other SQTS forms (N588K in HERG and V307L in KvLQT1), simulations using the D172N and WT/D172N mutations fully accounted for the ECG phenotype of tall and asymmetrically shaped T waves. Although we were unable to test for inducibility of arrhythmia susceptibility due to lack of patients' consent, our computer simulations predict a steeper steady-state restitution curve for the D172N and WT/D172N mutation, compared with WT or to HERG or KvLQT1 mutations, which may predispose SQT3 patients to a greater risk of reentrant arrhythmias.

Published
2005

25. Kass RS 23 , Kodama I 24 , Koren G 25 , Lord P 26 , Markhasin VS 27 , Matsuoka S 28 , McCulloch AD 29 , Mirams GR 2 , Morley GE 30

Author

Quinn, T.A., Granite, S., Allessie, M.A., Antzelevitch, C., Bollensdorff, C., Bub, G., Burton, R.A.B., Cerbai, E., Chen, P.S., Delmar, M., DiFrancesco, D., Earm, Y.E., Efimov, I.R., EGGER, M., Entcheva, E., Fink, M., Fischmeister, R., Franz, M.R., Garny, A., Giles, W.R., Hannes, T., Harding, S.E., Hunter, P.J., Iribe, G., Jalife, J., Johnson, C.R., Kass, R.S., Kodama, I., Koren, G., Lord, P., Markhasin, V.S., Matsuoka, S., McCulloch, A.D., Mirams, G.R., Morley, G.E., Nattel, S., Noble, D., Olesen, S.P., Panfilov, A.V., Trayanova, N.A., Ravens, U., Richard, S., Rosenbaum, D.S., Rudy, Y., Sachs, F., Sachse, F.B., Saint, D.A., Schotten, U., Solovyova, O., Taggart, P., Tung, L., Varró, A., Volders, P.G., Wang, K., Weiss, J.N., Wettwer, E., White, E., Wilders, R., Winslow, R.L., Kohl, P., Signalisation et physiopathologie cardiovasculaire (UMRS1180), and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

29. Atrioventricular conduction in mammalian species: Hemodynamic and electrical scaling

Author

Meijler, F.L., Billette, J., Jalife, J., Kik, M.J.L., Reiber, J.H.C., Stokhof, A.A., Westenberg, J.J.M., Wassenaar, C., and Strackee, J.

Subjects
Geneeskunde, atrioventricular conduction, ventricular filling, atrial contraction, evolution, scaling
Abstract

OBJECTIVES The purpose of this study was to investigate scaling of the duration of late diastolic left ventricular (LV) filling in relation to AV conduction time (delay) (PR interval on the ECG) in mammals. BACKGROUND From mouse to whale, AV delay increases 10-fold, whereas body mass increases one million-fold. The apparent "mismatch" results from scaling of AV delay versus body and heart mass. METHODS We measured (1) mitral orifice diameter in 138 postmortem hearts of 48 mammalian species weighing between 17 g and 250 kg and (2) transmitral diastolic flow using magnetic resonance imaging (MRI) recordings of 10 healthy human individuals. (3) We visually inspected early and late diastolic LV filling. (4) We developed two physical models to explain scaling of late diastolic LV filling time. RESULTS (1) Diameter of the mitral orifice proportionally relates to heart length (third root of heart mass). (2) Atrial contraction starts at a fixed instant (± 80%) of the (normalized) cardiac cycle and contributes 31% ± 5% to LV filling. (3) MRI shows that during diastole, the left atrium (LA) and LV form a single space. (4) The physical models relate the duration of late diastolic LV filling directly to heart length, the third root of heart mass. CONCLUSIONS (1) Late diastolic (LV) filling time scales with heart length (third root of heart mass). (2) No "mismateh" exists between AV delay and heart size. (3) Knowledge of the actual starting time of atrial contraction may contribute to better treatment of patients with heart failure. (4) The findings suggest that in evolution of mammalian species, hemodynamics commands electrical behavior of the heart.

Published
2005

32. What is the organization of waves in ventricular fibrillation?

Author

Omer Berenfeld, Pertsov, A. M., and Jalife, J.

Subjects
Periodicity, Heart Conduction System, Research Design, Guinea Pigs, Ventricular Fibrillation, Action Potentials, Animals, Reproducibility of Results, Signal Processing, Computer-Assisted, In Vitro Techniques, Electrophysiologic Techniques, Cardiac
Published
2001

33. AV Node Function during Atrial Fibrillation

Author

Meijler, F.L. and Jalife, J.

Subjects
Geneeskunde, atrial fibrillation, AV node function
Abstract

The A V node is a small cluster of cells, hardly visible in small rodents, and reaching the size of a chestnut in whales. In adult humans, it has the size and shape of an orange pit. Few, if any, structures of such small size in the mammalian body have such vital functions as does the A V node. Our understanding of the functions of the human A V conduction system in general, and of the A V node in particular, depends to a large extent on clinical empiricism and extrapolation of animal data. In thls chapter we will, in the footsteps of Purkinje, attempt to analyze mechanisms of AV node transmission in atrial fibrillation (AF) using empirically obtained clinical data and basic electrophysiologic prindples.

Published
2000

34. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing

Author

Quinn, T. A., Granite, S., Allessie, M. A., Antzelevitch, C., Bollensdorff, C., Bub, G., Burton, R. A. B., Cerbai, E., Chen, P. S., Delmar, M., DiFrancesco, D., Earm, Y. E., Efimov, I. R., Egger, M., Entcheva, E., Fink, M., Fischmeister, R., Franz, M. R., Garny, A., Giles, W. R., Hannes, T., Harding, S. E., Hunter, P. J., Iribe, G., Jalife, J., Johnson, C. R., Kass, R. S., Kodama, I., Koren, G., Lord, P., Markhasin, V. S., Matsuoka, S., McCulloch, A. D., Mirams, G. R., Morley, G. E., Nattel, S., Noble, D., Olesen, S. P., Panfilov, A. V., Trayanova, N. A., Ravens, U., Richard, S., Rosenbaum, D. S., Rudy, Y., Sachs, F., Sachse, F. B., Saint, D. A., Schotten, U., Solovyova, O., Taggart, P., Tung, L., Varro, A., Volders, P. G., Wang, K., Weiss, J. N., Wettwer, E., White, E., Wilders, R., Winslow, R. L., Kohl, P., Quinn, T. A., Granite, S., Allessie, M. A., Antzelevitch, C., Bollensdorff, C., Bub, G., Burton, R. A. B., Cerbai, E., Chen, P. S., Delmar, M., DiFrancesco, D., Earm, Y. E., Efimov, I. R., Egger, M., Entcheva, E., Fink, M., Fischmeister, R., Franz, M. R., Garny, A., Giles, W. R., Hannes, T., Harding, S. E., Hunter, P. J., Iribe, G., Jalife, J., Johnson, C. R., Kass, R. S., Kodama, I., Koren, G., Lord, P., Markhasin, V. S., Matsuoka, S., McCulloch, A. D., Mirams, G. R., Morley, G. E., Nattel, S., Noble, D., Olesen, S. P., Panfilov, A. V., Trayanova, N. A., Ravens, U., Richard, S., Rosenbaum, D. S., Rudy, Y., Sachs, F., Sachse, F. B., Saint, D. A., Schotten, U., Solovyova, O., Taggart, P., Tung, L., Varro, A., Volders, P. G., Wang, K., Weiss, J. N., Wettwer, E., White, E., Wilders, R., Winslow, R. L., and Kohl, P.

Published
2011

35. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE):standardised reporting for model reproducibility, interoperability, and data sharing

Author

Quinn, T A, Granite, S, Allessie, M A, Antzelevitch, C, Bollensdorff, C, Bub, G, Burton, R A B, Cerbai, E, Chen, P S, Delmar, M, Difrancesco, D, Earm, Y E, Efimov, I R, Egger, M, Entcheva, E, Fink, M, Fischmeister, R, Franz, M R, Garny, A, Giles, W R, Hannes, T, Harding, S E, Hunter, P J, Iribe, G, Jalife, J, Johnson, C R, Kass, R S, Kodama, I, Koren, G, Lord, P, Markhasin, V S, Matsuoka, S, McCulloch, A D, Mirams, G R, Morley, G E, Nattel, S, Noble, D, Olesen, Søren-Peter, Panfilov, A V, Trayanova, N A, Ravens, U, Richard, S, Rosenbaum, D S, Rudy, Y, Sachs, F, Sachse, F B, Saint, D A, Schotten, U, Solovyova, O, Taggart, P, Tung, L, Varró, A, Volders, P G, Wang, K, Weiss, J N, Wettwer, E, White, E, Wilders, R, Winslow, R L, Kohl, P, Quinn, T A, Granite, S, Allessie, M A, Antzelevitch, C, Bollensdorff, C, Bub, G, Burton, R A B, Cerbai, E, Chen, P S, Delmar, M, Difrancesco, D, Earm, Y E, Efimov, I R, Egger, M, Entcheva, E, Fink, M, Fischmeister, R, Franz, M R, Garny, A, Giles, W R, Hannes, T, Harding, S E, Hunter, P J, Iribe, G, Jalife, J, Johnson, C R, Kass, R S, Kodama, I, Koren, G, Lord, P, Markhasin, V S, Matsuoka, S, McCulloch, A D, Mirams, G R, Morley, G E, Nattel, S, Noble, D, Olesen, Søren-Peter, Panfilov, A V, Trayanova, N A, Ravens, U, Richard, S, Rosenbaum, D S, Rudy, Y, Sachs, F, Sachse, F B, Saint, D A, Schotten, U, Solovyova, O, Taggart, P, Tung, L, Varró, A, Volders, P G, Wang, K, Weiss, J N, Wettwer, E, White, E, Wilders, R, Winslow, R L, and Kohl, P

Abstract

Cardiac experimental electrophysiology is in need of a well-defined Minimum Information Standard for recording, annotating, and reporting experimental data. As a step towards establishing this, we present a draft standard, called Minimum Information about a Cardiac Electrophysiology Experiment (MICEE). The ultimate goal is to develop a useful tool for cardiac electrophysiologists which facilitates and improves dissemination of the minimum information necessary for reproduction of cardiac electrophysiology research, allowing for easier comparison and utilisation of findings by others. It is hoped that this will enhance the integration of individual results into experimental, computational, and conceptual models. In its present form, this draft is intended for assessment and development by the research community. We invite the reader to join this effort, and, if deemed productive, implement the Minimum Information about a Cardiac Electrophysiology Experiment standard in their own work.

Published
2011

36. Elektrofysiologie van de atrioventriculaire knoop tijdens atriumfibrilleren. I. Het kamerritme

Author

Meijler, F.L. and Jalife, J.

Subjects
Geneeskunde, electrophysiology of the AV node, atrial fibrillation
Abstract

– Atriumfibrilleren (AF) komt voor bij 0,9% van de bevolking, bij 6% van personen ouder dan 65 jaar en bij 10% van personen ouder dan 80 jaar. Het is een belangrijke onafhankelijke risicofactor voor trombo-embolie, in het bijzonder herseninfarcten. – De functies van de atrioventriculaire (AV-)knoop zijn: (a) een juiste afstemming van het tijdsverloop tussen de contracties van atria en ventrikels; (b) bescherming van de ventrikels tegen te hoge frequentie tijdens atriale tachycardie; (c) een pacemakerfunctie bij afwezige prikkels vanuit de atria (atriumstilstand). – AF is irregulaire, wanordelijke elektrische activiteit van de atria. Op het ECG ontbreken P-toppen en de basislijn vertoont golfjes die voortdurend veranderen van vorm, duur, amplitude en richting. – Het ontstaan en het voortbestaan van AF hangen samen met een voldoende groot aantal myocardcellen en een voldoende mate van onderling verschil tussen elekrische eigenschappen van de myocardcellen. – In afwezigheid van een AV-geleidingsblok is het kamerritme, dat er het gevolg van is, volledig irregulair (random). De irregulariteit van het kamerritme is constant en onafhankelijk van de kamerfrequentie en van de cardiale en andere eigenschappen van de patiënt. – Bij elektrische prikkeling van de rechter hartkamer ontstaat er een totaal AV-blok.

Published
1999

37. Elektrofysiologie van de atrioventriculaire knoop tijdens atriumfibrilleren. II. Beïnvloeding door atriumimpulsen

Author

Meijler, F.L. and Jalife, J.

Subjects
Geneeskunde, electrophysiology of the AV node, atrial fibrillation, concealed conduction
Abstract

– Een atriale impuls die niet zichtbaar wordt voortgeleid naar de ventrikel kan de geleiding van de volgende atriale impuls naar de ventrikels vertragen. Ook een ventriculaire extrasystole kan geleiding door de AV-knoop beïnvloeden. Dit verschijnsel wordt ‘concealed conduction’ genoemd. – Voor concealed conduction zijn tenminste 3 verklaringen mogelijk, maar verzwakking van de impuls naarmate de geleiding vordert, noch elektrotonische modulatie van de pacemakerfunctie van de AV-knoop is in overeenstemming met de waargenomen constante onregelmatigheid van het kamerritme tijdens atriumfibrilleren. – Het meest waarschijnlijke mechanisme dat het kamerritme tijdens atriumfibrilleren kan verklaren, is de elektrotonische verandering (inhibitie) door atriumimpulsen van de geleidingseigenschappen van de AV-knoop.

Published
1999

44. AV nodal function during atrial fibrillation: the role of electrotonic modulation of propagation

Author

Meijler, F.L., Jalife, J., Beaumont, J., and Vaidya, D.

Subjects
Geneeskunde, irregular ventricular rhythm, concealed conduction, electrotonic modulation of AV conduction, atrial fibrilation
Abstract

The irregular ventricular rhythm that accompanies atrial fibrillation (AF) has been explained in terms of concealed conduction within the AV node (AVN). However, the cellular basis of concealed conduction in AF remains poorly understood. Our hypothesis is that electrotonic modulation of AVN propagation by atrial impulses blocked repetitively within the AVN is responsible for changes in function that lead to irregular ventricular rhythms in patients with AF. We have tested this idea using two different simplified computer ionic models of the AVN. The first ("black-box") model consisted of three cells: one representing the atrium, another one representing the AVN, and a third one representing the ventricle. The black-box model was used to establish the rules of behavior and predictions to be tested in a second, more elaborate model of the AVN. The latter ('nine-cell' model) incorporated a linear array of nine cells separated into three different regions. The first region of two cells represented the atrium; the second region of five cells represented the AV node; and the third region of two cells represented the ventricle. Cells were connected by appropriate coupling resistances. During regular atrial pacing, both models reproduced very closely the frequency dependence of AV conduction and refractoriness seen in patients and experimental animals. In addition, atrial impulses blocked within the AV node led to electrotonic inhibition or facilitation of propagation of immediately succeeding impulses. During simulated AF, using the nine-cell model, random variations in the atrial (A-A) interval yielded variations in the ventricular (V-V) interval but there was no scaling, i.e., the V-V intervals were not multiples of the A-A intervals. As such, the model simulated the statistical behavior of the ventricles in patients with AF, including: (1) the ventricular rhythm was random; and (2) the coefficient of variation (standard deviation/mean) of the ventricular rhythm was relatively constant at any given mean V-V interval. Analysis of cell responses revealed that repetitive atrial input at random A-A intervals resulted in complex patterns of concealment within the AVN cells. Consequently, the effects of electrotonic modulation were also random, which resuIted in a smearing of the AV conduction curve over A-A intervals that were larger than those predicted for 1:1 AV conduction. Hence, during AF, electrotonic modulation acts in concert with the frequency dependence of AVN conduction to result in complex patterns of ventricular activation. Finally, similarly to what was shown in patients, VVI pacing of the ventricle in the nine-cell model at the appropriate frequency led to blockade of nearly all anterograde (i.e., A-V) impulses. The essential feature here was that the retrograde impulse invading the AVN cells was followed by refractoriness with slow recovery of excitability, setting the stage for electrotonic inhibition of anterograde impulses. Overall, the results provide insight into the cellular mechanisms underlying AVN function and irregular ventricular response during AF.

Published
1996

47. High-rate pacing-induced atrial fibrillation effectively reveals properties of spontaneously occurring paroxysmal atrial fibrillation in humans

Author

Calvo, D., primary, Atienza, F., additional, Jalife, J., additional, Martinez-Alzamora, N., additional, Bravo, L., additional, Almendral, J., additional, Gonzalez-Torrecilla, E., additional, Arenal, A., additional, Bermejo, J., additional, Fernandez-Aviles, F., additional, and Berenfeld, O., additional

Published
2012
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50. Fibrillation Induced by High-Rate Pacing From Either the Pulmonary Veins, the Right Atrium or the Coronary Sinus Reveals Properties of Spontaneously Occurring Paroxysmal Atrial Fibrillation in Humans

Author

Atienza, F., primary, Calvo, D., additional, Jalife, J., additional, Bravo, L., additional, Almendral, J., additional, Gonzalez-Torrecilla, E., additional, Arenal, A., additional, Bermejo, J., additional, Fernandez-Aviles, F., additional, and Berenfeld, O., additional

Published
2011
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