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Your search keyword '"Jalaludeen, Abdulkadhar Mohamed"' showing total 7 results
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7 results on '"Jalaludeen, Abdulkadhar Mohamed"'

4. In-vivo and In-vitro Antioxidant Activity of Troxerutin on Nickel Induced Toxicity in Experimental Rats

Author

Elangovan, Perumal, Jalaludeen, Abdulkadhar Mohamed, Ramakrishnan, Ramalingam, Amutha, Kasinathan, and Pari, Leelavinothan

Subjects
Troxerutin, Nickel, Free radical, Original Article, Reducing power, Antioxidants, Hydroxyl radical
Abstract

The aim of the present study was to evaluate the effect of troxerutin (TXN) on Nickel (Ni) toxicity by using rats and in-vitro model. Ni toxicity induced in male albino wistar rats (20 mg/kg body weight (b.w) was administered orally for 20 days). TXN was administered orally (100 mg/kg (b.w) for 20 days with administration of Ni. The toxic effect of Ni and the action of TXN was measure by determining the lipid peroxidation markers and antioxidant levels in plasma and various in-vitro antioxidant systems. TXN exhibited a significant (p < 0.05) antioxidant activity in Ni induced toxicity by reversing the changes observed in TBARS, HP, Vitamin C, E and GSH. The free radical scavenging properties of TXN at different concentrations (10-50ug/mL) were investigated with various in-vitro methods such as 2, 2’-diphenyl-1- picrylhydrazyl radical (DPPH), 2, 2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS•+), hydroxyl radical, superoxide anion scavenging activity and reducing power. Among the different concentrations, 50 μg/mL of TXN was more effective compared to other concentrations in all in-vitro assays. The above study conclude that TXN possesses potent in-vivo and in-vitro antioxidant activity with effective free radical scavenger for potential therapeutic value

Published
2020

7. Biochanin A Ameliorates Arsenic-Induced Hepato- and Hematotoxicity in Rats.

Author

Jalaludeen, Abdulkadhar Mohamed, Woo Tae Ha, Ran Lee, Jin Hoi Kim, Jeong Tae Do, Chankyu Park, Young Tae Heo, Won Young Lee, and Hyuk Song

Subjects
*BIOCHANIN A, *GENISTEIN, *HEPATOTOXICOLOGY, *ARSENIC poisoning, *SEPSIS
Abstract

Biochanin A (BCA) is a natural organic compound of the phytoestrogenic isoflavone class that has antioxidant and metal chelator properties in the presence of transition metal ions, however, its efficacy in animal models is still obscure. Therefore, the objective of this study was to investigate the protective effects of BCA against arsenic-induced hepatic injury and hematotoxicity in rats. The results suggest that arsenic intoxicated rats showed significantly higher levels of plasma hepatic markers than normal control rats. Furthermore, an increase in lipid peroxidation with depletion of reduced glutathione (GSH) and activities of superoxide dismutase (SOD) and catalase (CAT) occurred in the livers of rats exposed to arsenic. Administration of BCA (20 mg/kg⋅bw/day) and selenium (3 mg/kg⋅bw/day) resulted in a significant reversal of hepatic and oxidative stress markers in arsenic-intoxicated rats. A low dose of BCA (10 mg/kg⋅bw/day) did not show any preventive effect, while a high dose of BCA (40 mg/kg⋅bw/day) partially prevented all hepatotoxicity events. These biochemical perturbations were supported by histopathological observations of the liver. Our results suggest that administration of BCA (20 mg/kg⋅bw/day) attenuated the arsenic hepatotoxicity, a property that could contribute to the therapeutic approaches for chronic liver diseases. [ABSTRACT FROM AUTHOR]

Published
2016
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