36 results on '"Jalali, Amirhossein"'
Search Results
2. Short-term outcomes following total correction of tetralogy of fallot in adult patients
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Khajali, Zahra, Mohammadi, Nasibeh, Toloueitabar, Yaser, Maleki, Majid, Saedi, Sedigheh, Norouzi, Zeinab, Mazloum-Zadeh, Saeedeh, Chenaghlou, Maryam, Jalali, Amirhossein, Tatari, Hassan, and Aliramezany, Maryam
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- 2023
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3. Optimal Management of Asymptomatic Carotid Artery Stenosis: A Systematic Review and Network Meta-Analysis
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Gasior, Sara A., O’Donnell, John P.M., Davey, Matthew, Clarke, James, Jalali, Amirhossein, Ryan, Éanna, Aherne, Thomas M., and Walsh, Stewart R.
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- 2023
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4. Uncommon manifestation of Ebstein anomaly: A case report of apical displacement involving all tricuspid valve leaflets
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Jalali, Amirhossein, primary, Khajali, Zahra, additional, Parsaee, Mozhgan, additional, Behrooj, Soudabe, additional, Salehi, Pegah, additional, Akbarian, Mahsa, additional, Shemshadi, Sara, additional, and Hooshyar, Dariush, additional
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- 2024
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5. AB071. SOH24AB_184. Evaluating preoperative neutrophil-lymphocyte ratio as a predictive biomarker in primary breast cancer
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Jaffer, Alisha, primary, Cullinane, Carolyn, additional, Davey, Matthew, additional, Isik, Burce, additional, Jalali, Amirhossein, additional, Buckley, Juliette, additional, Baban, Chwanrow, additional, Merrigan, Bridget Anne, additional, and Tormey, Shona, additional
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- 2024
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6. NRXN1α+/- is associated with increased excitability in ASD iPSC-derived neurons
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Avazzadeh, Sahar, Quinlan, Leo R., Reilly, Jamie, McDonagh, Katya, Jalali, Amirhossein, Wang, Yanqin, McInerney, Veronica, Krawczyk, Janusz, Ding, Yicheng, Fitzgerald, Jacqueline, O’Sullivan, Matthew, Forman, Eva B., Lynch, Sally A., Ennis, Sean, Feerick, Niamh, Reilly, Richard, Li, Weidong, Shen, Xu, Yang, Guangming, Lu, Yin, Peeters, Hilde, Dockery, Peter, O’Brien, Timothy, Shen, Sanbing, and Gallagher, Louise
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- 2021
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7. Integrating inflammatory serum biomarkers into a risk calculator for prostate cancer detection
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Jalali, Amirhossein, Kitching, Michael, Martin, Kenneth, Richardson, Ciaran, Murphy, Thomas Brendan, FitzGerald, Stephen Peter, Watson, Ronald William, and Perry, Antoinette Sabrina
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- 2021
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8. Midterm prognosis following total correction of tetralogy of fallot in adult patients
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Khajali, Zahra, primary, Mohammadi, Nasibeh, additional, Toloueitabar, Yaser, additional, Maleki, Majid, additional, Saedi, Sedigheh, additional, nourouzi, Zeinab, additional, Mazloum-Zadeh, Saeideh, additional, Chenaghloo, Maryam, additional, Jalali, Amirhossein, additional, Tatari, Hassan, additional, and Aliramezany, Maryam, additional
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- 2023
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9. Designing infographics in health research with patients and the public: A scoping review protocol
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Beecher, Blaze, primary, O’Doherty, Alan, additional, Goulao, Beatriz, additional, Jalali, Amirhossein, additional, Salsberg, Jon, additional, Dore, Liz, additional, and Hannigan, Ailish, additional
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- 2023
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10. P53 loss of heterozygosity (LOH) in formalin-fixed paraffin-embedded leiomyosarcoma (LMS): a novel report
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McMahon, John N., primary, Gaffney, Eoin F., additional, Aliaga-Kelly, William J., additional, Stephens, John F., additional, Jalali, Amirhossein, additional, and Curran, Bernadette, additional
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- 2023
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11. A risk calculator to inform the need for a prostate biopsy: a rapid access clinic cohort
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Jalali, Amirhossein, Foley, Robert W., Maweni, Robert M., Murphy, Keefe, Lundon, Dara J., Lynch, Thomas, Power, Richard, O’Brien, Frank, O’Malley, Kieran J., Galvin, David J., Durkan, Garrett C., Murphy, T. Brendan, and Watson, R. William
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- 2020
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12. Exploring neutrophil-lymphocyte ratio as a predictor of postoperative breast cancer recurrence
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Jaffer, Alisha, primary, Cullinane, Carolyn, additional, Jalali, Amirhossein, additional, Feeney, Gerard, additional, and Tormey, Shona, additional
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- 2023
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13. AB014. SOH23ABS_149. Exploring neutrophil-lymphocyte ratio as a predictor of postoperative breast cancer recurrence
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Jaffer, Alisha, primary, Cullinane, Carolyn, additional, Jalali, Amirhossein, additional, Feeney, Gerard, additional, and Tormey, Shona, additional
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- 2023
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14. Increased Ca2+ signaling in NRXN1α+/− neurons derived from ASD induced pluripotent stem cells
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Avazzadeh, Sahar, McDonagh, Katya, Reilly, Jamie, Wang, Yanqin, Boomkamp, Stephanie D., McInerney, Veronica, Krawczyk, Janusz, Fitzgerald, Jacqueline, Feerick, Niamh, O’Sullivan, Matthew, Jalali, Amirhossein, Forman, Eva B., Lynch, Sally A., Ennis, Sean, Cosemans, Nele, Peeters, Hilde, Dockery, Peter, O’Brien, Timothy, Quinlan, Leo R., Gallagher, Louise, and Shen, Sanbing
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- 2019
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15. A Novel Surrogate Nomogram Capable of Predicting OncotypeDX Recurrence Score©
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Davey, Matthew G., Jalali, Amirhossein, J.Ryan, Éanna, P.McLaughlin, Ray, Sweeney, Karl J, K. Barry, Michael, Malone, Carmel M., Lowery, Aoife J., Miller, Nicola, and Kerin, Michael J.
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42 Health sciences ,breast cancer ,genomics ,Health sciences ,personalized medicine ,FOS: Health sciences - Abstract
Background: OncotypeDX Recurrence Score© (RS) is a commercially available 21-gene expression assay which estimates prognosis and guides chemoendocrine prescription in early-stage estrogen-receptor positive, human epidermal growth factor receptor-2-negative (ER+/HER2−) breast cancer. Limitations of RS testing include the cost and turnaround time of several weeks. Aim: Our aim is to develop a user-friendly surrogate nomogram capable of predicting RS. Methods: Multivariable linear regression analyses were performed to determine predictors of RS and RS > 25. Receiver operating characteristic analysis produced an area under the curve (AUC) for each model, with training and test sets were composed of 70.3% (n = 315) and 29.7% (n = 133). A dynamic, user-friendly nomogram was built to predict RS using R (version 4.0.3). Results: 448 consecutive patients who underwent RS testing were included (median age: 58 years). Using multivariable regression analyses, postmenopausal status (β-Coefficient: 0.25, 95% confidence intervals (CIs): 0.03–0.48, p = 0.028), grade 3 disease (β-Coefficient: 0.28, 95% CIs: 0.03–0.52, p = 0.026), and estrogen receptor (ER) score (β-Coefficient: −0.14, 95% CIs: −0.22–−0.06, p = 0.001) all independently predicted RS, with AUC of 0.719. Using multivariable regression analyses, grade 3 disease (odds ratio (OR): 5.67, 95% CIs: 1.32–40.00, p = 0.037), decreased ER score (OR: 1.33, 95% CIs: 1.02–1.66, p = 0.050) and decreased progesterone receptor score (OR: 1.16, 95% CIs: 1.06–1.25, p = 0.002) all independently predicted RS > 25, with AUC of 0.740 for the static and dynamic online nomogram model. Conclusions: This study designed and validated an online user-friendly nomogram from routinely available clinicopathological parameters capable of predicting outcomes of the 21-gene RS expression assay
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- 2023
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16. Peripheral Blood Cell Ratios as Prognostic Indicators in a Neoadjuvant Chemotherapy-Treated Breast Cancer Cohort
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Jalali, Amirhossein, primary, Miresse, David, additional, Fahey, Matthew R., additional, Ni Mhaonaigh, Niamh, additional, McGuire, Andrew, additional, Bourke, Emer, additional, Kerin, Michael J., additional, and Brown, James A. L., additional
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- 2022
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17. Pulsatile versus non-pulsatile perfusion in coronary artery bypass operation: The comparison of laboratory and clinical outcomes.
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Shahandashti, Farshad Jalili, Asadian, Sanaz, Habibi, Neda, Gorjipour, Farhad, Jalali, Amirhossein, and Toloueitabar, Yaser
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INTENSIVE care units ,LIVER function tests ,BIOMARKERS ,LENGTH of stay in hospitals ,EVALUATION of medical care ,STATISTICS ,CORONARY artery bypass ,KIDNEY function tests ,ANALYSIS of variance ,BLOOD urea nitrogen ,SURGERY ,PATIENTS ,QUANTITATIVE research ,RANDOMIZED controlled trials ,COMPARATIVE studies ,QUALITATIVE research ,T-test (Statistics) ,HEART rate monitoring ,DESCRIPTIVE statistics ,LACTATES ,CHI-squared test ,REPEATED measures design ,LACTATE dehydrogenase ,BLOOD circulation ,CARDIOPULMONARY bypass ,STATISTICAL sampling ,URINALYSIS ,DATA analysis ,PERFUSION ,PULSE (Heart beat) ,CREATININE - Abstract
Introduction: The superiority of pulsatile or non-pulsatile perfusion in cardiopulmonary bypass (CPB) regarding morbidity and mortality is still debated. Therefore, we aimed to investigate the effect of different pulse rates in pulsatile perfusion in patients undergoing coronary artery bypass graft (CABG) and compared it with non-pulsatile perfusion. Materials and Methods: In this randomized clinical trial, 90 patients who were all candidates for CABG under CPB were enrolled. Patients in groups A and B received pulsatile perfusion with 30 and 70 pulses per minute, and group C received non-pulsatile perfusion. The biochemical and clinical parameters in the ICU were evaluated in the study groups. Results: There was no statistically significant difference between patients' clinical outcomes and kidney and liver function markers (all Ps> 0.05). Mean serum lactate level increased but did not show a statistically significant difference between the study groups (p = 0.8). The mean urine volume at 12 and 24 h after surgery was higher in group A, but there was no statistically significant difference between the three groups during the study period (p = 0.3). No significant difference was found in the length of the ICU stay between the study groups (p = 0.2). Conclusion: Our studied parameters demonstrated no significant difference between pulsatile and non-pulsatile and between 30 and 70 pulse rate pulsatile perfusion methods. Our findings support that pulsatile perfusion with different pulse rates has no advantages over non-pulsatile perfusion in selected CABG cases. [ABSTRACT FROM AUTHOR]
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- 2023
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18. The CHARMS pilot study: a multi-method assessment of the feasibility of a sexual counselling implementation intervention in cardiac rehabilitation in Ireland
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Murphy, Patrick J., Noone, Chris, D’Eath, Maureen, Casey, Dympna, Doherty, Sally, Jaarsma, Tiny, Murphy, Andrew W., O’Donnell, Martin, Fallon, Noeleen, Gillespie, Paddy, Jalali, Amirhossein, Sharry, Jenny Mc, Newell, John, Toomey, Elaine, Steinke, Elaine E., and Byrne, Molly
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- 2018
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19. Establishing electroporation thresholds for targeted cell specific cardiac ablation in a 2D culture model
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Avazzadeh, Sahar, primary, Dehkordi, Mahshid H., additional, Owens, Peter, additional, Jalali, Amirhossein, additional, O'Brien, Barry, additional, Coffey, Ken, additional, O'Halloran, Martin, additional, Fernhead, Howard O., additional, Keane, David, additional, and Quinlan, Leo. R, additional
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- 2022
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20. Outcomes of Saphenous Vein Intervention in the Management of Superficial Venous Incompetence: A Systematic Review and Network Meta-Analysis
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Gasior, Sara Anne, primary, O’Donnell, John P., additional, Aherne, Tom, additional, Jalali, Amirhossein, additional, Tang, Tjun, additional, Ryan, Manna, additional, and Walsh, Stewart R., additional
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- 2022
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21. A Novel Surrogate Nomogram Capable of Predicting OncotypeDX Recurrence Score©
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Davey, Matthew G., primary, Jalali, Amirhossein, additional, Ryan, Éanna J., additional, McLaughlin, Ray P., additional, Sweeney, Karl J., additional, Barry, Michael K., additional, Malone, Carmel M., additional, Keane, Maccon M., additional, Lowery, Aoife J., additional, Miller, Nicola, additional, and Kerin, Michael J., additional
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- 2022
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22. The Use of MRI Based Risk Calculators in Prostate Cancer Diagnosis: A Systematic Review
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Courtney O’Toole, Ciarán, Boakye, Nancy Fosua, Hannigan, Ailish, and Jalali, Amirhossein
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- 2024
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23. Pulsatile versus non-pulsatile perfusion in coronary artery bypass operation: The comparison of laboratory and clinical outcomes
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Shahandashti, Farshad Jalili, primary, Asadian, Sanaz, additional, Habibi, Neda, additional, Gorjipour, Farhad, additional, Jalali, Amirhossein, additional, and Toloueitabar, Yaser, additional
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- 2022
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24. Integrating Serum Biomarkers into Prediction Models for Biochemical Recurrence Following Radical Prostatectomy
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Moghaddam, Shirin, primary, Jalali, Amirhossein, additional, O’Neill, Amanda, additional, Murphy, Lisa, additional, Gorman, Laura, additional, Reilly, Anne-Marie, additional, Heffernan, Áine, additional, Lynch, Thomas, additional, Power, Richard, additional, O’Malley, Kieran J., additional, Taskèn, Kristin A., additional, Berge, Viktor, additional, Solhaug, Vivi-Ann, additional, Klocker, Helmut, additional, Murphy, T. Brendan, additional, and Watson, R. William, additional
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- 2021
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25. Nomogram to Predict the Overall Survival of Colorectal Cancer Patients: A Multicenter National Study
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Borumandnia, Nasrin, primary, Doosti, Hassan, additional, Jalali, Amirhossein, additional, Khodakarim, Soheila, additional, Charati, Jamshid Yazdani, additional, Pourhoseingholi, Mohamad Amin, additional, Talebi, Atefeh, additional, and Agah, Shahram, additional
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- 2021
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26. Additional file 1 of NRXN1α+/- is associated with increased excitability in ASD iPSC-derived neurons
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Avazzadeh, Sahar, Quinlan, Leo R., Reilly, Jamie, McDonagh, Katya, Jalali, Amirhossein, Wang, Yanqin, McInerney, Veronica, Krawczyk, Janusz, Ding, Yicheng, Fitzgerald, Jacqueline, O’Sullivan, Matthew, Forman, Eva B., Lynch, Sally A., Ennis, Sean, Feerick, Niamh, Reilly, Richard, Li, Weidong, Shen, Xu, Yang, Guangming, Lu, Yin, Peeters, Hilde, Dockery, Peter, O’Brien, Timothy, Shen, Sanbing, and Gallagher, Louise
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Data_FILES - Abstract
Additional file 1. Additional figures and tables.
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- 2021
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27. Outcomes of Saphenous Vein Intervention in the Management of Superficial Venous Incompetence
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Gasior, Sara A., primary, O’Donnell, John P. M., additional, Aherne, Thomas M., additional, Jalali, Amirhossein, additional, Tang, Tjun, additional, Ryan, Éanna J., additional, and Walsh, Stewart R., additional
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- 2021
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28. AB043. SOH21AS188. Outcomes of saphenous vein intervention in the management of superficial venous incompetence: a systematic review and network meta-analysis
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Gasior, Sara Anne, primary, O’Donnell, John Phineas, additional, Aherne, Tom, additional, Jalali, Amirhossein, additional, Ryan, Éanna, additional, and Walsh, Stewart, additional
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- 2021
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29. Outcomes of Saphenous Vein Intervention in the Management of Superficial Venous Incompetence: A Systematic Review and Network Meta-analysis.
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Gasior, Sara A., O'Donnell, John P. M., Aherne, Thomas M., Jalali, Amirhossein, Tang, Tjun, Ryan, Éanna J., and Walsh, Stewart R.
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Supplemental Digital Content is available in the text Objective: To determine the most effective modality of intervention to treat saphenous vein insufficiency. Summary of Background Data: Endovenous therapies have instigated a paradigm shift in the management of superficial venous incompetence. When compared with open surgery, endovenous interventions (foam sclerotherapy, radiofrequency ablation, endovenous laser ablation (EVLA), mechanochemical ablation, and CAE closure) potentially offer reduced morbidity with similar procedural efficacy. Methods: A systematic review and series of network meta-analyses of randomized controlled trials were performed assessing risks of procedural failure (within 6-weeks) and recurrence (6-weeks to 5-years), defined by ultrasound, between the different modalities of intervention for superficial venous incompetence. Treatment comparisons addressing risks of common adverse events, venous clinical severity score, and pain were also performed. Results: A systematic search identified 51 articles, describing 36 randomized controlled trials, incorporating 7576 limbs. Outcome data on 10 modalities of intervention were analyzed up to 5-year follow-up. CAE resulted in the lowest risk of procedural failure within 6-weeks. Foam sclerotherapy had the highest risk of recurrence while high ligation with stripping (HLS) and Conservatrice Hemodynamique de l'Insuffisance Veineuse en Ambulatoire were ranked best to reduce long-term recurrence. No intervention increased risks of venous thromboembolism and there was minimal difference in morbidity between treatments. All interventions improved venous clinical severity score (range −1.02 to −4.95), however, radiofrequency ablation demonstrated the greatest improvement, followed by EVLA and HLS between 2 to 5-years. EVLA was associated with the highest risk of pain, while mechanochemical ablation offered the least. Conclusions: Although CAE offered the lowest risk of initial procedural failure, HLS resulted in lower rates of long-term recurrence without considerably increasing morbidity when compared with other endovenous options. [ABSTRACT FROM AUTHOR]
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- 2022
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30. NRXN1α+/- is associated with increased excitability in ASD iPSC-derived neurons.
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Avazzadeh, Sahar, Quinlan, Leo R., Reilly, Jamie, McDonagh, Katya, Jalali, Amirhossein, Wang, Yanqin, McInerney, Veronica, Krawczyk, Janusz, Ding, Yicheng, Fitzgerald, Jacqueline, O'Sullivan, Matthew, Forman, Eva B., Lynch, Sally A., Ennis, Sean, Feerick, Niamh, Reilly, Richard, Li, Weidong, Shen, Xu, Yang, Guangming, and Lu, Yin
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INDUCED pluripotent stem cells ,AUTISM spectrum disorders ,NEURONS ,ACTION potentials ,POTASSIUM channels - Abstract
Background: NRXN1 deletions are identified as one of major rare risk factors for autism spectrum disorder (ASD) and other neurodevelopmental disorders. ASD has 30% co-morbidity with epilepsy, and the latter is associated with excessive neuronal firing. NRXN1 encodes hundreds of presynaptic neuro-adhesion proteins categorized as NRXN1α/β/γ. Previous studies on cultured cells show that the short NRXN1β primarily exerts excitation effect, whereas the long NRXN1α which is more commonly deleted in patients involves in both excitation and inhibition. However, patient-derived models are essential for understanding functional consequences of NRXN1α deletions in human neurons. We recently derived induced pluripotent stem cells (iPSCs) from five controls and three ASD patients carrying NRXN1α+/- and showed increased calcium transients in patient neurons.Methods: In this study we investigated the electrophysiological properties of iPSC-derived cortical neurons in control and ASD patients carrying NRXN1α+/- using patch clamping. Whole genome RNA sequencing was carried out to further understand the potential underlying molecular mechanism.Results: NRXN1α+/- cortical neurons were shown to display larger sodium currents, higher AP amplitude and accelerated depolarization time. RNASeq analyses revealed transcriptomic changes with significant upregulation glutamatergic synapse and ion channels/transporter activity including voltage-gated potassium channels (GRIN1, GRIN3B, SLC17A6, CACNG3, CACNA1A, SHANK1), which are likely to couple with the increased excitability in NRXN1α+/- cortical neurons.Conclusions: Together with recent evidence of increased calcium transients, our results showed that human NRXN1α+/- isoform deletions altered neuronal excitability and non-synaptic function, and NRXN1α+/- patient iPSCs may be used as an ASD model for therapeutic development with calcium transients and excitability as readouts. [ABSTRACT FROM AUTHOR]- Published
- 2021
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31. Translational statistics and dynamic nomograms
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Jalali, Amirhossein, Newell, John, Alvarez-Iglesias, Alberto, HRB Clinical Research Facility, Galway, and Health Research Board
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Visualisation ,Translational statistics ,R Shiny ,Dynamic nomograms ,Mean residual life function ,Mathematics, Statistics and Applied Mathematics - Abstract
Translational Medicine, within biomedical and public health research domains, is defined as the convergence of basic and clinical research with the aim to transfer knowledge on the benefits and risks of therapies. The concept of Translational Statistics is proposed to facilitate the integration of biostatistics within clinical research to enhance communication of statistical research findings in an accurate and accessible manner to diverse audiences (e.g. policy makers, patients and the media). The use of appropriate visualisation is central to all areas of statistical research. Providing meaningful graphical representations of data is necessary to identify features about the population from which the data were sampled and may throw up an unsuspected view of the data such as a pattern or unusual observations. Informative graphical representations of statistical models play an important translational role. Static nomograms have been used to visualise statistical models. In this study, we propose the use of dynamic nomograms as a visualisation and translational tool to further aid the communication of the results of a statistical analysis to a non-statistical audience. A visualisation tool for time-to-event data is presented which contains a collection of useful graphical summaries, in particular, the Mean Residual Life function. It includes the classical survival summaries as well as the dynamic prediction for survival function and the mean residual life function as the two attractive alternatives. In theory, most regression-type models presented in the literature could have an accompanying web address to direct the reader to the corresponding dynamic nomogram allowing them to 'interact' with the model to gain insight into the effect of each explanatory variable on the primary response. 2020-03-20
- Published
- 2018
32. Visualising statistical models using dynamic nomograms
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Jalali, Amirhossein, primary, Alvarez-Iglesias, Alberto, additional, Roshan, Davood, additional, and Newell, John, additional
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- 2019
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33. Mid-term outcomes of surgical repair for anomalous origin of the left coronary artery from the pulmonary artery: In infants, children and adults
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Al-Dairy, Alwaleed, primary, Dehaki, MaziarGholampour, additional, Rezaei, Yousef, additional, Ghavidel, AlirezaAlizadeh, additional, Omrani, Gholamreza, additional, Givtaj, Nader, additional, Afjehi, RezaSadat, additional, Tatari, Hassan, additional, Jalali, AmirHossein, additional, and Mahdavi, Mohammad, additional
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- 2017
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34. An Exploratory Study of Capacity Assessment in Medical Practice in Ireland.
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Spain, Eimear, Davidson, Hope, O’Donnell, Patrick, Jalali, Amirhossein, McKittrick, Seoidin, and Leo, Roisin
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PHYSICIANS , *PATIENT autonomy , *CAPACITY (Law) , *GENERAL practitioners , *COMMON law - Abstract
The current legal test for capacity under the common law is a functional test. It determines whether a person can make a particular decision at a particular time; it focuses on retained abilities rather than on presumed deficits – in order to promote patient autonomy in decision-making. International evidence suggests however that the test is not well understood and consequently not being correctly applied in practice by a range of medical professionals. Donnelly has argued that gaining a better understanding of how capacity assessments are actually employed is essential to improving the quality of assessments. To date, there is little data on how doctors in particular make their assessments in practice. Using a socio-legal methodology, this quantitative study aims to assess understanding of capacity among a group of general practitioners/family medicine doctors in Ireland, and to determine how they assess capacity in clinical practice. Our study found that notwithstanding a lack of confidence in their ability to assess decision-making capacity, that respondents in fact demonstrated a high level of understanding and of ability to correctly apply the functional test in practice. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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35. A Comparison Of Emergence Agitation Between Succinylcholine And Rocuronium.
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Amniati, Saied, Malekpour, Sepideh, Khatibi, Ali, Kiaei, Mehrdad Mesbah, Jalali, Amirhossein, and Jafarian, Ali Akbar
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ROCURONIUM bromide , *SUCCINYLCHOLINE , *PSYCHOLOGICAL distress , *TRACHEA intubation , *ODDS ratio - Abstract
Introduction: Agitation immediately after EA operation is one of the common problems during recovery, especially in children. In general, agitation is defined as a set of physical symptoms or emotional distress that includes the following symptoms alone or together: crying, restlessness, clutching, demonstrations, verbal kicking, and purposeful or purposeless behaviors that may have a logical connection. Method: In this study, 60 patients in the age range of 20 to 50 years who were in ASA I and II categories were subjected to tracheal intubation in two groups by rapid sequence induction method. The first group received 3 μg/kg of fentanyl and 0.5 mg/kg of lidocaine for premedication and were given induction with 1 mg/kg of succinylcholine and 5 mg/kg of nesdonal. The second group received 3 μg/kg of fentanyl and 0.5 mg/kg of lidocaine for premedication and were given induction with 0.6 mg/kg of rocuronium and 5 mg/kg of nesdonal. After surgery, the incidence, intensity and duration of agitation when the patient woke up in both groups was recorded by a physician based on Riker's criteria. Also, the occurrence of myalgia and its persistence from one to 24 hours after the operation were assessed. Results: According to the results of this clinical trial, succinylcholine and rocuronium were not significantly different from each other in terms of the occurrence of agitation, its intensity and duration, but based on the results of the odds ratio, the probability that in patients who took rocuronium they found that agitation is 0.6 times less than the patients who received succinylcholine. Logistic analysis of the data also showed that in patients who received succinylcholine, the probability of agitation being more severe is 2.47 times higher than in patients who received rocuronium. The duration of agitation in patients receiving succinylcholine was also higher than in patients receiving rocuronium. In terms of the incidence and severity of myalgia, there was no significant difference in the people who received rocuronium or succinylcholine, however, a total of 50% of the patients showed agitation symptoms, showed myalgia, of which 16.6% were related to the people who received rocuronium and 33.3% were related to patients who received succinylcholine. The results of the myalgia odds ratio also showed that the probability of myalgia symptoms being observed in patients who received rocuronium is 0.5 times lower than in patients who received succinylcholine. Conclusion: In aggregate, the results of this trial showed that rocuronium can be a suitable alternative to succinylcholine in applications outside the operating room. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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36. 2023 Canadian Surgery Forum: Sept. 20-23, 2023.
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Brière R, Émond M, Benhamed A, Blanchard PG, Drolet S, Habashi R, Golbon B, Shellenberger J, Pasternak J, Merchant S, Shellenberger J, La J, Sawhney M, Brogly S, Cadili L, Horkoff M, Ainslie S, Demetrick J, Chai B, Wiseman K, Hwang H, Alhumoud Z, Salem A, Lau R, Aw K, Nessim C, Gawad N, Alibhai K, Towaij C, Doan D, Raîche I, Valji R, Turner S, Balmes PN, Hwang H, Hameed SM, Tan JGK, Wijesuriya R, Tan JGK, Hew NLC, Wijesuriya R, Lund M, Hawel J, Gregor J, Leslie K, Lenet T, McIsaac D, Hallet J, Jerath A, Lalu M, Nicholls S, Presseau J, Tinmouth A, Verret M, Wherrett C, Fergusson D, Martel G, Sharma S, McKechnie T, Talwar G, Patel J, Heimann L, Doumouras A, Hong D, Eskicioglu C, Wang C, Guo M, Huang L, Sun S, Davis N, Wang J, Skulsky S, Sikora L, Raîche I, Son HJ, Gee D, Gomez D, Jung J, Selvam R, Seguin N, Zhang L, Lacaille-Ranger A, Sikora L, McIsaac D, Moloo H, Follett A, Holly, Organ M, Pace D, Balvardi S, Kaneva P, Semsar-Kazerooni K, Mueller C, Vassiliou M, Al Mahroos M, Fiore JF 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