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3. Reduced-Intensity Compared to Nonmyeloablative Conditioning in Patients with Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Author

Nath, Karthik, Peterson, Kristen, Brown, Samantha, Devlin, Sean, Rodriguez, Natasia, Barker, Juliet, Giralt, Sergio, Gyurkocza, Boglarka, Jakubowski, Ann, Papadopoulos, Esperanza, Ponce, Doris, Scordo, Michael, Shah, Gunjan, Perales, Miguel-Angel, Sauter, Craig, Lin, Andrew, and Dahi, Parastoo B.

Published
2024
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4. Association between busulfan exposure and survival in patients undergoing a CD34+ selected stem cell transplantation

Author

Tamari, Roni, Scordo, Michael, Kunvarjee, Binni M., Proli, Anthony, Lin, Andrew, Flynn, Jessica, Cho, Christina, Devlin, Sean, Klein, Elizabeth, Boulad, Farid, Cancio, Maria I., Curran, Kevin J., Jakubowski, Ann A., Kernan, Nancy A., Kung, Andrew L., O’Reilly, Richard J., Papadopoulos, Esperanza B., Prockop, Susan, Scaradavou, Andromachi, Shaffer, Brian C., Shah, Gunjan, Spitzer, Barbara, Gyurkocza, Boglarka, Giralt, Sergio A., Perales, Miguel-Angel, and Boelens, Jaap Jan

Published
2023
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5. Analysis of disparities in time to allogeneic transplantation in adults with acute myelogenous leukemia

Author

Fingrut, Warren B., Gyurkocza, Boglarka, Flynn, Jessica, Davis, Eric, Devlin, Sean, Scaradavou, Andromachi, Chinapen, Stephanie, Quach, Sean, Cho, Christina, Giralt, Sergio A., Jakubowski, Ann A., Lin, Richard J., Papadopoulos, Esperanza B., Perales, Miguel-Angel, Ponce, Doris, Shaffer, Brian C., Tamari, Roni, Young, James W., Politikos, Ioannis, and Barker, Juliet N.

Published
2023
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7. Low-dose unfractionated heparin prophylaxis is a safe strategy for the prevention of hepatic sinusoidal obstruction syndrome after myeloablative adult allogenic stem cell transplant

Author

Sola, Maria, Bhatt, Valkal, Palazzo, Meighan, Cavalier, Kathleen E., Devlin, Sean M., Maloy, Molly, Barker, Juliet N., Castro-Malaspina, Hugo, Chung, David, Dahi, Parastoo B., Jakubowski, Ann A., Landau, Heather, Papadopoulos, Esperanza B., Perales, Miguel-Angel, Sauter, Craig, Tamari, Roni, Kernan, Nancy A., Giralt, Sergio, Young, James W., Goldberg, Jenna D., and Ponce, Doris M.

Published
2022
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8. Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors

Author

Pulsipher, Michael A, Logan, Brent R, Kiefer, Deidre M, Chitphakdithai, Pintip, Riches, Marcie L, Rizzo, J Douglas, Anderlini, Paolo, Leitman, O’Susan F, Kobusingye, Hati, Besser, RaeAnne M, Miller, John P, Drexler, Rebecca J, Abdel-Mageed, Aly, Ahmed, Ibrahim A, Akard, Luke P, Artz, Andrew S, Ball, Edward D, Bayer, Ruthee-Lu, Bigelow, Carolyn, Bolwell, Brian J, Broun, E Randolph, Delgado, David C, Duckworth, Katharine, Dvorak, Christopher C, Hahn, Theresa E, Haight, Ann E, Hari, Parameswaran N, Hayes-Lattin, Brandon M, Jacobsohn, David A, Jakubowski, Ann A, Kasow, Kimberly A, Lazarus, Hillard M, Liesveld, Jane L, Linenberger, Michael, Litzow, Mark R, Longo, Walter, Magalhaes-Silverman, Margarida, McCarty, John M, McGuirk, Joseph P, Mori, Shahram, Parameswaran, Vinod, Prasad, Vinod K, Rowley, Scott D, Rybka, Witold B, Sahdev, Indira, Schriber, Jeffrey R, Selby, George B, Shaughnessy, Paul J, Shenoy, Shalini, Spitzer, Thomas, Tse, William T, Uberti, Joseph P, Vusirikala, Madhuri, Waller, Edmund K, Weisdorf, Daniel J, Yanik, Gregory A, Navarro, Willis H, Horowitz, Mary M, Switzer, Galen E, Confer, Dennis L, and Shaw, Bronwen E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Transplantation, Patient Safety, Regenerative Medicine, Clinical Research, Neurosciences, Stem Cell Research - Nonembryonic - Human, Chronic Pain, Pain Research, Stem Cell Research, Adolescent, Adult, Female, Humans, Living Donors, Male, Middle Aged, Peripheral Blood Stem Cell Transplantation, Peripheral Blood Stem Cells, Prospective Studies, Quality of Life, Unrelated Donors, Young Adult, Cardiorespiratory Medicine and Haematology, Immunology, Cardiovascular medicine and haematology
Abstract

Unlike unrelated donor registries, transplant centers lack uniform approaches to related donor assessment and deferral. To test whether related donors are at increased risk for donation-related toxicities, we conducted a prospective observational trial of 11,942 related and unrelated donors aged 18-60 years. Bone marrow (BM) was collected at 37 transplant and 78 National Marrow Donor Program centers, and peripheral blood stem cells (PBSC) were collected at 42 transplant and 87 unrelated donor centers in North America. Possible presence of medical comorbidities was verified prior to donation, and standardized pain and toxicity measures were assessed pre-donation, peri-donation, and one year following. Multivariate analyses showed similar experiences for BM collection in related and unrelated donors; however, related stem cell donors had increased risk of moderate [odds ratios (ORs) 1.42; P

Published
2019

9. Effect of Aging and Predonation Comorbidities on the Related Peripheral Blood Stem Cell Donor Experience: Report from the Related Donor Safety Study.

Author

Pulsipher, Michael A, Logan, Brent R, Chitphakdithai, Pintip, Kiefer, Deidre M, Riches, Marcie L, Rizzo, J Douglas, Anderlini, Paolo, Leitman, Susan F, Varni, James W, Kobusingye, Hati, Besser, RaeAnne M, Miller, John P, Drexler, Rebecca J, Abdel-Mageed, Aly, Ahmed, Ibrahim A, Akard, Luke P, Artz, Andrew S, Ball, Edward D, Bayer, Ruthee-Lu, Bigelow, Carolyn, Bolwell, Brian J, Broun, E Randolph, Bunin, Nancy J, Delgado, David C, Duckworth, Katharine, Dvorak, Christopher C, Hahn, Theresa E, Haight, Ann E, Hari, Parameswaran N, Hayes-Lattin, Brandon M, Jacobsohn, David A, Jakubowski, Ann A, Kasow, Kimberly A, Lazarus, Hillard M, Liesveld, Jane L, Linenberger, Michael, Litzow, Mark R, Longo, Walter, Magalhaes-Silverman, Margarida, McCarty, John M, McGuirk, Joseph P, Mori, Shahram, Prasad, Vinod K, Rowley, Scott D, Rybka, Witold B, Sahdev, Indira, Schriber, Jeffrey R, Selby, George B, Shaughnessy, Paul J, Shenoy, Shalini, Spitzer, Thomas, Tse, William T, Uberti, Joseph P, Vusirikala, Madhuri, Waller, Edmund K, Weisdorf, Daniel J, Yanik, Gregory A, Navarro, Willis H, Horowitz, Mary M, Switzer, Galen E, Shaw, Bronwen E, and Confer, Dennis L

Subjects
Humans, Peripheral Blood Stem Cell Transplantation, Comorbidity, Adolescent, Adult, Aged, Middle Aged, Blood Donors, Female, Male, Young Adult, Peripheral Blood Stem Cells, BM collection toxicities, Donor safety, PBSC collection toxicities, Stem cell transplantation, Transplantation, Pain Research, Stem Cell Research - Nonembryonic - Human, Clinical Research, Chronic Pain, Stem Cell Research, Aging, Clinical Sciences, Immunology
Abstract

The development of reduced-intensity approaches for allogeneic hematopoietic cell transplantation has resulted in growing numbers of older related donors (RDs) of peripheral blood stem cells (PBSCs). The effects of age on donation efficacy, toxicity, and long-term recovery in RDs are poorly understood. To address this we analyzed hematologic variables, pain, donation-related symptoms, and recovery in 1211 PBSC RDs aged 18 to 79 enrolled in the Related Donor Safety Study. RDs aged > 60 had a lower median CD34+ level before apheresis compared with younger RDs (age > 60, 59 × 106/L; age 41 to 60, 81 × 106/L; age 18 to 40, 121 × 106/L; P < .001). This resulted in older donors undergoing more apheresis procedures (49% versus 30% ≥ 2 collections, P < .001) and higher collection volumes (52% versus 32% > 24 L, P < .001), leading to high percentages of donors aged > 60 with postcollection thrombocytopenia

Published
2019

11. The Simplified Comorbidity Index: a new tool for prediction of nonrelapse mortality in allo-HCT

Author

Shouval, Roni, Fein, Joshua A., Cho, Christina, Avecilla, Scott T., Ruiz, Josel, Tomas, Ana Alarcon, Sanchez-Escamilla, Miriam, Flores, Nerea Castillo, Yáñez, Lucrecia, Barker, Juliet N., Dahi, Parastoo, Giralt, Sergio A., Geyer, Alexander I., Gyurkocza, Boglarka, Jakubowski, Ann A., Lin, Richard J., O'Reilly, Richard J., Papadopoulos, Esperanza B., Politikos, Ioannis, Ponce, Doris M., Sauter, Craig S., Scordo, Michael, Shaffer, Brian, Shah, Gunjan L., Sullivan, James P., Tamari, Roni, van den Brink, Marcel R.M., Young, James W., Nagler, Arnon, Devlin, Sean, Shimoni, Avichai, and Perales, Miguel-Angel

Published
2022
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12. Antithymocyte globulin exposure in CD34+ T-cell–depleted allogeneic hematopoietic cell transplantation

Author

Lakkaraja, Madhavi, Scordo, Michael, Mauguen, Audrey, Cho, Christina, Devlin, Sean, Ruiz, Josel D., Klein, Elizabeth, Avecilla, Scott T., Boulad, Farid, Cancio, Maria I., Curran, Kevin J., Jakubowski, Ann A., Kernan, Nancy A., Kung, Andrew L., O'Reilly, Richard J., Papadopoulos, Esperanza B., Prockop, Susan, van Roessel, Ichelle, Scaradavou, Andromachi, Shaffer, Brian C., Shah, Gunjan, Spitzer, Barbara, Tamari, Roni, Giralt, Sergio A., Perales, Miguel-Angel, and Boelens, Jaap Jan

Published
2022
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13. Allogeneic Stem Cell Transplantation for Advanced Myelodysplastic Syndrome: Comparison of Outcomes between CD34+ Selected and Unmodified Hematopoietic Stem Cell Transplantation

Author

Tamari, Roni, Oran, Betul, Hilden, Patrick, Maloy, Molly, Kongtim, Piyanuch, Papadopoulos, Esperanza B, Rondon, Gabriela, Jakubowski, Ann A, Andersson, Borje S, Devlin, Sean M, Ahmed, Sairah, Popat, Uday R, Ponce, Doris, Chen, Julianne, Sauter, Craig, Young, James W, de Lima, Marcos, Perales, Miguel-Angel, O'Reilly, Richard J, Giralt, Sergio A, Champlin, Richard E, and Castro-Malaspina, Hugo

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Rare Diseases, Clinical Research, Transplantation, Stem Cell Research - Nonembryonic - Human, Orphan Drug, Stem Cell Research, Regenerative Medicine, Adult, Aged, Allografts, Antigens, CD34, Chromosome Aberrations, Female, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Lymphocyte Depletion, Male, Middle Aged, Myelodysplastic Syndromes, Recurrence, Risk Assessment, Survival Analysis, Transplantation, Homologous, Treatment Outcome, Myelodysplastic syndrome, Allogeneic transplantation, T cell depletion, Unmodified, Clinical Sciences, Immunology, Cardiovascular medicine and haematology
Abstract

In this study, we compared transplantation outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) in patients with advanced myelodysplastic syndrome (MDS) who received a CD34+ cell-selected and those who received an unmodified allograft. This analysis initially included 181 patients, 60 who received a CD34+ cell-selected transplant and 121 who received an unmodified transplant. Owing to significant differences in disease characteristics, the analysis was limited to patients with

Published
2018

16. Third-party cytomegalovirus-specific T cells improved survival in refractory cytomegalovirus viremia after hematopoietic transplant

Author

Prockop, Susan E., Hasan, Aisha, Doubrovina, Ekaterina, Dahi, Parastoo B., Rodriguez-Sanchez, Irene, Curry, Michael, Mauguen, Audrey, Papanicolaou, Genovefa A., Su, Yiqi, Yao, JinJuan, Arcila, Maria, Boulad, Farid, Castro- Malaspina, Hugo, Cho, Christina, Curran, Kevin J., Giralt, Sergio, Kernan, Nancy A., Koehne, Guenther, Jakubowski, Ann, Papadopoulos, Esperanza, Perales, Miguel-Angel, Politikos, Ioannis, Price, Keith, Selvakumar, Annamalai, Sauter, Craig S., Tamari, Roni, Vizconde, Teresa, Young, James W., and O'Reilly, Richard J.

Subjects
T cells -- Health aspects, Cellular therapy -- Testing, Viremia -- Care and treatment, Cytomegalovirus infections -- Care and treatment, Hematopoietic stem cells -- Transplantation, Health care industry
Abstract

BACKGROUND. Refractory CMV viremia and disease are associated with significant morbidity and mortality in recipients of hematopoietic stem cell transplant (HCT). METHODS. In phase I/II trials, we treated 67 subjects for CMV viremia or disease arising after HCT with adoptive transfer of banked, third-party, CMVpp65-sensitized T cells (CMVpp65-VSTs). All were evaluable for toxicity and 59 for response. Evaluable subjects had CMV disease or persisting viremia that had failed at least 2 weeks of induction therapy with a median of 3 antiviral drugs; 84.7% had more than 3 of 11 high-risk features. CMVpp65-VSTs were specific for 1 to 3 CMVpp65 epitopes, presented by a limited set of HLA class I or II alleles, and were selected based on high-resolution HLA matching at 2 of 10 HLA alleles and matching for subject and subject's HCT donor for 1 or more alleles through which the CMVpp65- VSTs were restricted. RESULTS. T cell infusions were well tolerated. Of 59 subjects evaluable for response, 38 (64%) achieved complete or durable partial responses. CONCLUSIONS. Recipients responding to CMVpp65VSTs experienced an improved overall survival. Of the risk factors evaluated, transplant type, recipient [CD4.sup.+] and [CD8.sup.+] T cell levels prior to adoptive therapy, and the HLA restriction of CMVpp65-VSTs infused each significantly affected responses. In addition, CMVpp65-specific T cells of HCT donor or recipient origin contributed to the durability of both complete and partial responses. TRIAL REGISTRATION. NCT00674648; NCT01646645; NCT02136797 (NIH). FUNDING. NIH (P01 CA23766, R21 CA162002 and P30 CA008748); Aubrey Fund; Claire Tow Foundation; Major Family Foundation; 'Rick' Eisemann Pediatric Research Fund; Banbury Foundation; Edith Robertson Foundation; Larry Smead Foundation., Introduction Cytomegalovirus (CMV) infections remain a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplants (HCTs) (1-5). Although prophylactic or preemptive treatment with ganciclovir and/or foscarnet and, [...]

Published
2023
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17. Reduced-intensity conditioning hematopoietic stem cell transplantation for chronic lymphocytic leukemia and Richter's transformation

Author

Lahoud, Oscar B., Devlin, Sean M., Maloy, Molly A., Roeker, Lindsey E., Dahi, Parastoo B., Ponce, Doris M., Gyurkocza, Boglarka, Koehne, Guenther, Young, James W., Castro-Malaspina, Hugo R., Barker, Juliet N., Papadopoulos, Esperanza B., Jakubowski, Ann A., Zelenetz, Andrew D., Mato, Anthony R., Giralt, Sergio A., Perales, Miguel A., and Sauter, Craig S.

Published
2021
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20. Development and validation of a disease risk stratification system for patients with haematological malignancies: a retrospective cohort study of the European Society for Blood and Marrow Transplantation registry

Author

Shouval, Roni, Fein, Joshua A, Labopin, Myriam, Cho, Christina, Bazarbachi, Ali, Baron, Frédéric, Bug, Gesine, Ciceri, Fabio, Corbacioglu, Selim, Galimard, Jacques-Emmanuel, Giebel, Sebastian, Gilleece, Maria H, Giralt, Sergio, Jakubowski, Ann, Montoto, Silvia, O'Reilly, Richard J, Papadopoulos, Esperanza B, Peric, Zinaida, Ruggeri, Annalisa, Sanz, Jaime, Sauter, Craig S, Savani, Bipin N, Schmid, Christoph, Spyridonidis, Alexandros, Tamari, Roni, Versluis, Jurjen, Yakoub-Agha, Ibrahim, Perales, Miguel Angel, Mohty, Mohamad, and Nagler, Arnon

Published
2021
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21. High progression-free survival after intermediate intensity double unit cord blood transplantation in adults

Author

Barker, Juliet N., Devlin, Sean M., Naputo, Kristine A., Skinner, Kelcey, Maloy, Molly A., Flynn, Lisa, Anagnostou, Theodora, Avecilla, Scott T., Scaradavou, Andromachi, Cho, Christina, Dahi, Parastoo B., Giralt, Sergio A., Gyurkocza, Boglarka, Hanash, Alan M., Hsu, Katharine, Jakubowski, Ann A., Papadopoulos, Esperanza B., Peled, Jonathan U., Perales, Miguel-Angel, Sauter, Craig S., Shah, Gunjan L., Shaffer, Brian C., Tamari, Roni, Young, James W., Roshal, Mikhail, O'Reilly, Richard J., Ponce, Doris M., and Politikos, Ioannis

Published
2020
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24. Ex Vivo T Cell-Depleted Hematopoietic Stem Cell Transplantation for Adult Patients with Acute Myelogenous Leukemia in First and Second Remission: Long-Term Disease-Free Survival with a Significantly Reduced Risk of Graft-versus-Host Disease

Author

Montoro, Juan, Ceberio, Izaskun, Hilden, Patrick, Maloy, Molly A., Barker, Juliet, Castro-Malaspina, Hugo, Dahi, Parastoo, Koehne, Guenther, Perales, Miguel-Angel, Ponce, Doris, Sauter, Craig, Shaffer, Brian, Tamari, Roni, Young, James W., Giralt, Sergio A., O'Reilly, Richard J., Jakubowski, Ann A., and Papadopoulos, Esperanza B.

Published
2020
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25. Letermovir for Prevention of Cytomegalovirus Reactivation in Haploidentical and Mismatched Adult Donor Allogeneic Hematopoietic Cell Transplantation with Post-Transplantation Cyclophosphamide for Graft-versus-Host Disease Prophylaxis

Author

Lin, Andrew, Flynn, Jessica, DeRespiris, Lauren, Figgins, Bradley, Griffin, Meagan, Lau, Carmen, Proli, Anthony, Devlin, Sean M., Cho, Christina, Tamari, Roni, Jakubowski, Ann A., Papadopoulos, Esperanza B., Giralt, Sergio A., Perales, Miguel-Angel, Seo, Susan K., and Shaffer, Brian

Published
2020
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26. High Progression-Free Survival with Low Relapse Rates after Double-Unit Cord Blood Transplantation in Patients with High-Risk AML

Author

Politikos, Ioannis, primary, Brown, Samantha, additional, Fingrut, Warren Benjamin, additional, Chinapen, Ms. Stephanie, additional, Quach, Sean, additional, Dahi, Parastoo B., additional, Gyurkocza, Boglarka, additional, Jakubowski, Ann A., additional, Papadopoulos, Esperanza B., additional, Perales, Miguel-Angel, additional, Ponce, Doris M., additional, Tamari, Roni, additional, Scaradavou, Andromachi, additional, and Barker, Juliet, additional

Published
2024
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27. Early CD4 and B Cell Immune Reconstitution As Predictors of Outcomes in T Cell Depleted Allogeneic Hematopoietic Cell Transplantation

Author

Lucas, Alexandre G. Troullioud, primary, Scordo, Michael, additional, Lakkaraja, Madhavi, additional, Cho, Christina, additional, Jakubowski, Ann A., additional, Papadopoulos, Esperanza B., additional, Tamari, Roni, additional, Curran, Kevin J., additional, O'Reilly, Richard J., additional, Scaradavou, Andromachi, additional, Gyurkocza, Boglarka, additional, Giralt, Sergio A., additional, Perales, Miguel-Angel, additional, and Boelens, Jaap Jan, additional

Published
2024
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28. Engraftment kinetics after transplantation of double unit cord blood grafts combined with haplo-identical CD34+ cells without antithymocyte globulin

Author

Politikos, Ioannis, Devlin, Sean M., Arcila, Maria E., Barone, Jonathan C., Maloy, Molly A., Naputo, Kristine A., Ruiz, Josel D., Mazis, Christopher M., Scaradavou, Andromachi, Avecilla, Scott T., Dahi, Parastoo B., Giralt, Sergio A., Hsu, Katherine C., Jakubowski, Ann A., Papadopoulos, Esperanza B., Perales, Miguel A., Sauter, Craig S., Tamari, Roni, Ponce, Doris M., O’Reilly, Richard J., and Barker, Juliet N.

Published
2021
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29. Geriatric syndromes in 2-year, progression-free survivors among older recipients of allogeneic hematopoietic cell transplantation

Author

Lin, Richard J., Baser, Raymond E., Elko, Theresa A., Korc-Grodzicki, Beatriz, Shahrokni, Armin, Maloy, Molly A., Young, James W., Tamari, Roni, Shah, Gunjan L., Shaffer, Brian C., Scordo, Michael, Sauter, Craig S., Ponce, Doris M., Politikos, Ioannis, Perales, Miguel-Angel, Papadopoulos, Esperanza B., Gyurkocza, Boglarka, Dahi, Parastoo B., Cho, Christina, Barker, Juliet N., Tomas, Ana Alarcón, Flores, Nerea Castillo, Sanchez-Escamilla, Míriam, Segundo, Lucrecia Yáñez San, Jakubowski, Ann A., and Giralt, Sergio A.

Published
2021
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30. Off-the-shelf EBV-specific T cell immunotherapy for rituximab-refractory EBV-associated lymphoma following transplantation

Author

Prockop, Susan, Doubrovina, Ekaterina, Suser, Stephanie, Heller, Glenn, Barker, Juliet, Dahi, Parastoo, Perales, Miguel A., Papadopoulos, Esperanza, Sauter, Craig, Castro-Malaspina, Hugo, Boulad, Farid, Curran, Kevin J., Giralt, Sergio, Gyurkocza, Boglarka, Hsu, Katharine C., Jakubowski, Ann, Hanash, Alan M., Kernan, Nancy A., Kobos, Rachel, Koehne, Guenther, Landau, Heather, Ponce, Doris, Spitzer, Barbara, Young, James W., Behr, Gerald, Dunphy, Mark, Haque, Sofia, Teruya-Feldstein, Julie, Arcila, Maria, Moung, Christine, Hsu, Susan, Hasan, Aisha, and O'Reilly, Richard J.

Subjects
T cells, Banks (Finance), Antineoplastic agents, Non-Hodgkin's lymphomas -- Development and progression, Immunotherapy, Drug approval, Antimitotic agents, Health care industry, Memorial Sloan-Kettering Cancer Center
Abstract

BACKGROUND. Adoptive transfer of donor-derived EBV-specific cytotoxic T-lymphocytes (EBV-CTLs) can eradicate EBV- associated lymphomas (EBV-PTLD) after transplantation of hematopoietic cell (HCT) or solid organ (SOT) but is unavailable for most patients. METHODS. We developed a third-party, allogeneic, off-the-shelf bank of 330 GMP-grade EBV-CTL lines from specifically consented healthy HCT donors. We treated 46 recipients of HCT (n = 33) or SOT (n = 13) with established EBV-PTLD, who had failed rituximab therapy, with third-party EBV-CTLs. Treatment cycles consisted of 3 weekly infusions of EBV-CTLs and 3 weeks of observation. RESULTS. EBV-CTLs did not induce significant toxicities. One patient developed grade I skin graft-versus-host disease. Complete remission (CR) or sustained partial remission (PR) was achieved in 68% of HCT recipients and 54% of SOT recipients. For patients who achieved CR/PR or stable disease after cycle 1, one year overall survival was 88.9% and 81.8%, respectively. In addition, 3 of 5 recipients with POD after a first cycle who received EBV-CTLs from a different donor achieved CR or durable PR (60%) and survived longer than 1 year. Maximal responses were achieved after a median of 2 cycles. CONCLUSION. Third-party EBV-CTLs of defined HLA restriction provide safe, immediately accessible treatment for EBV- PTLD. Secondary treatment with EBV-CTLs restricted by a different HLA allele (switch therapy) can also induce remissions if initial EBV-CTLs are ineffective. These results suggest a promising potential therapy for patients with rituximab-refractory EBV-associated lymphoma after transplantation. TRIAL REGISTRATION. Phase II protocols (NCT01498484 and NCT00002663) were approved by the Institutional Review Board at Memorial Sloan Kettering Cancer Center, the FDA, and the National Marrow Donor Program. FUNDING. This work was supported by NIH grants CA23766 and R21CA162002, the Aubrey Fund, the Claire Tow Foundation, the Major Family Foundation, the Max Cure Foundation, the Richard 'Rick' J. Eisemann Pediatric Research Fund, the Banbury Foundation, the Edith Robertson Foundation, and the Larry Smead Foundation. Atara Biotherapeutics licensed the bank of third-party EBV-CTLs from Memorial Sloan Kettering Cancer Center in June 2015., Introduction EBV-induced lymphomas are a significant cause of morbidity and mortality for recipients of allogeneic hematopoietic cell transplants (HCTs) and solid organ transplants (SOTs) (1-5). While decreasing immunosuppression can induce [...]

Published
2020
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32. Impact of geriatric vulnerabilities on allogeneic hematopoietic cell transplantation outcomes in older patients with hematologic malignancies

Author

Lin, Richard J., Elko, Theresa A., Devlin, Sean M., Shahrokni, Armin, Jakubowski, Ann A., Dahi, Parastoo B., Perales, Miguel-Angel, Tamari, Roni, Shaffer, Brian C., Sauter, Craig S., Papadopoulos, Esperanza B., Gyurkocza, Boglarka, Korc-Grodzicki, Beatriz, Barker, Juliet N., Maloy, Molly A., and Giralt, Sergio A.

Published
2020
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34. Standard Antithymocyte Globulin Dosing Results in Poorer Outcomes in Overexposed Patients after Ex Vivo CD34+ Selected Allogeneic Hematopoietic Cell Transplantation

Author

Scordo, Michael, Bhatt, Valkal, Hilden, Patrick, Smith, Melody, Thoren, Katie, Cho, Christina, Shah, Gunjan L., Maloy, Molly A., Papadopoulos, Esperanza B., Jakubowski, Ann A., Avecilla, Scott T., O'Reilly, Richard J., Castro-Malaspina, Hugo, Tamari, Roni, Shaffer, Brian C., Boelens, Jaap J., Perales, Miguel-Angel, and Giralt, Sergio A.

Published
2019
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36. Non-Graft-versus-Host Disease Ocular Complications after Hematopoietic Cell Transplantation: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation

Author

Inamoto, Yoshihiro, Petriček, Igor, Burns, Linda, Chhabra, Saurabh, DeFilipp, Zachariah, Hematti, Peiman, Rovó, Alicia, Schears, Raquel, Shah, Ami, Agrawal, Vaibhav, Ahmed, Aisha, Ahmed, Ibrahim, Ali, Asim, Aljurf, Mahmoud, Alkhateeb, Hassan, Beitinjaneh, Amer, Bhatt, Neel, Buchbinder, Dave, Byrne, Michael, Callander, Natalie, Fahnehjelm, Kristina, Farhadfar, Nosha, Gale, Robert Peter, Ganguly, Siddhartha, Hashmi, Shahrukh, Hildebrandt, Gerhard C., Horn, Erich, Jakubowski, Ann, Kamble, Rammurti T., Law, Jason, Lee, Catherine, Nathan, Sunita, Penack, Olaf, Pingali, Ravi, Prasad, Pinki, Pulanic, Drazen, Rotz, Seth, Shreenivas, Aditya, Steinberg, Amir, Tabbara, Khalid, Tichelli, André, Wirk, Baldeep, Yared, Jean, Basak, Grzegorz W., Battiwalla, Minoo, Duarte, Rafael, Savani, Bipin N., Flowers, Mary E.D., Shaw, Bronwen E., and Valdés-Sanz, Nuria

Published
2019
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39. Burden and impact of multifactorial geriatric syndromes in allogeneic hematopoietic cell transplantation for older adults

Author

Lin, Richard J., Hilden, Patrick D., Elko, Theresa A., Dahi, Parastoo B., Shahrokni, Armin, Jakubowski, Ann A., Perales, Miguel-Angel, Sauter, Craig S., Castro-Malaspina, Hugo R., Barker, Juliet N., Shaffer, Brian C., Tamari, Roni, Papadopoulos, Esperanza B., Maloy, Molly A., Korc-Grodzicki, Beatriz, and Giralt, Sergio A.

Published
2019
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40. Reduced-Intensity Compared to Nonmyeloablative Conditioning in Patients with Non-Hodgkin Lymphoma Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Author

Nath, Karthik, primary, Peterson, Kristen, additional, Brown, Samantha, additional, Devlin, Sean, additional, Rodriguez, Natasia, additional, Barker, Juliet, additional, Giralt, Sergio, additional, Gyurkocza, Boglarka, additional, Jakubowski, Ann, additional, Papadopoulos, Esperanza, additional, Ponce, Doris, additional, Scordo, Michael, additional, Shah, Gunjan, additional, Perales, Miguel-Angel, additional, Sauter, Craig, additional, Lin, Andrew, additional, and Dahi, Parastoo B., additional

Published
2023
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41. Early Fluid Overload Is Associated with an Increased Risk of Nonrelapse Mortality after Ex Vivo CD34-Selected Allogeneic Hematopoietic Cell Transplantation

Author

Rondon-Clavo, Carlos, Scordo, Michael, Hilden, Patrick, Shah, Gunjan L., Cho, Christina, Maloy, Molly A., Papadopoulos, Esperanza B., Jakubowski, Ann A., O'Reilly, Richard J., Gyurkocza, Boglarka, Castro-Malaspina, Hugo, Tamari, Roni, Shaffer, Brian C., Perales, Miguel-Angel, Jaimes, Edgar A., and Giralt, Sergio A.

Published
2018
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42. CD34+ Cell Selection versus Reduced-Intensity Conditioning and Unmodified Grafts for Allogeneic Hematopoietic Cell Transplantation in Patients Age >50 Years with Acute Myelogenous Leukemia and Myelodysplastic Syndrome

Author

Barba, Pere, Martino, Rodrigo, Zhou, Qin, Cho, Christina, Castro-Malaspina, Hugo, Devlin, Sean, Esquirol, Albert, Giralt, Sergio, Jakubowski, Ann A., Caballero, Dolores, Maloy, Molly, Papadopoulos, Esperanza B., Piñana, José Luís, Fox, María Laura, Márquez-Malaver, Francisco J., Valcárcel, David, Solano, Carlos, López-Corral, Lucía, Sierra, Jorge, and Perales, Miguel-Angel

Published
2018
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43. Intravenous Busulfan Compared with Total Body Irradiation Pretransplant Conditioning for Adults with Acute Lymphoblastic Leukemia

Author

Hogan, William, Battiwalla, Minoo, Copelan, Edward, Hildebrandt, Gerhard, Ganguly, Sid, Majhail, Navneet, Woolfrey, Ann, Nivison-Smith, Ian, Hertzberg, Mark, Diaz, Miguel Angel, Jakubowski, Ann, Ustun, Celalettin, Yong, Agnes, Freytes, Cesar, DeFilipp, Zachariah, Inamoto, Yoshi, Cahn, Jean-Yves, Savani, Bipin, Yared, Jean, Bajel, Ashish, Bacher, Ulrike, Uy, Geoffrey, Rizzieri, David, Wieduwilt, Matthew, Schultz, Kirk, Grunwald, Michael, Kamble, Rammurti, Qayed, Muna, Brammer, Jonathan, Ballen, Karen, Khera, Nandita, Schouten, Harry, Bierings, Marc, Kanakry, Christopher, Wood, William Allen, Saad, Ayman, Savoie, Lynn, Hamilton, Betty Ky, Aljurf, Mahmoud, Vij, Ravi, Pawarode, Attaphol, Olsson, Richard, Wirk, B. Mona, Beitinjaneh, Amer, Seo, Sachiko, Cerny, Jan, Akpek, Gorgun, Norkin, Maxim, Nishihori, Taiga, Lazaryan, Aleksandr, Sabloff, Mitchell, Kebriaei, Partow, Anasetti, Claudio, Zhang, Mei-Jie, Wang, Hai-Lin, Aldoss, Ibrahim, de Lima, Marcos, Khoury, H. Jean, Sandmaier, Brenda M., Horowitz, Mary M., Artz, Andrew, Bejanyan, Nelli, Ciurea, Stefan, Lazarus, Hillard M., Gale, Robert Peter, Litzow, Mark, Bredeson, Christopher, Seftel, Matthew D., Pulsipher, Michael A., Boelens, Jaap-Jan, Alvarnas, Joseph, Champlin, Richard, Forman, Stephen, Pullarkat, Vinod, Weisdorf, Daniel, and Marks, David I.

Published
2018
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44. Effects of Late Toxicities on Outcomes in Long-Term Survivors of Ex-Vivo CD34+-Selected Allogeneic Hematopoietic Cell Transplantation

Author

Scordo, Michael, Shah, Gunjan L., Kosuri, Satyajit, Herrera, Diego Adrianzen, Cho, Christina, Devlin, Sean M., Maloy, Molly A., Nieves, Jimmy, Borrill, Taylor, Avecilla, Scott T., Meagher, Richard C., Carlow, Dean C., O'Reilly, Richard J., Papadopoulos, Esperanza B., Jakubowski, Ann A., Koehne, Guenther, Gyurkocza, Boglarka, Castro-Malaspina, Hugo, Tamari, Roni, Perales, Miguel-Angel, Giralt, Sergio A., and Shaffer, Brian C.

Published
2018
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45. Impact of Toxicity on Survival for Older Adult Patients after CD34+ Selected Allogeneic Hematopoietic Stem Cell Transplantation

Author

Shah, Gunjan L., Scordo, Michael, Kosuri, Satyajit, Herrera, Diego Adrianzen, Cho, Christina, Devlin, Sean M., Borrill, Taylor, Carlow, Dean C., Avecilla, Scott T., Meagher, Richard C., O'Reilly, Richard J., Jakubowski, Ann A., Papadopoulos, Esperanza B., Koehne, Guenther, Gyurkocza, Boglarka, Castro-Malaspina, Hugo, Shaffer, Brian C., Perales, Miguel-Angel, Giralt, Sergio A., and Tamari, Roni

Published
2018
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46. Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT

Author

Inamoto, Yoshihiro, Petriček, Igor, Burns, Linda, Chhabra, Saurabh, DeFilipp, Zack, Hematti, Peiman, Rovó, Alicia, Schears, Raquel, Shah, Ami, Agrawal, Vaibhav, Al-Khinji, Aisha, Ahmed, Ibrahim, Ali, Asim, Aljurf, Mahmoud, Alkhateeb, Hassan, Beitinjaneh, Amer, Bhatt, Neel, Buchbinder, Dave, Byrne, Michael, Callander, Natalie, Fahnehjelm, Kristina, Farhadfar, Nosha, Gale, Robert Peter, Ganguly, Siddhartha, Hildebrandt, Gerhard C., Horn, Erich, Jakubowski, Ann, Kamble, Rammurti T., Law, Jason, Lee, Catherine, Nathan, Sunita, Penack, Olaf, Pingali, Ravi, Prasad, Pinki, Pulanic, Drazen, Rotz, Seth, Shreenivas, Aditya, Steinberg, Amir, Tabbara, Khalid, Tichelli, André, Wirk, Baldeep, Yared, Jean, Basak, Grzegorz W., Battiwalla, Minoo, Duarte, Rafael, Savani, Bipin N., Flowers, Mary E. D., Shaw, Bronwen E., and Valdés-Sanz, Nuria

Published
2019
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47. Immune Dysfunction from Radiation Exposure

Author

Hollingsworth, Brynn A., primary, Aldrich, Jennifer T., additional, Case, Cullen M., additional, DiCarlo, Andrea L., additional, Hoffman, Corey M., additional, Jakubowski, Ann A., additional, Liu, Qian, additional, Loelius, Shannon G., additional, PrabhuDas, Mercy, additional, Winters, Thomas A., additional, and Cassatt, David R., additional

Published
2023
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48. Prospective analysis to determine barriers to allogeneic hematopoietic cell transplantation in patients with acute leukemia

Author

Nath, Karthik, primary, Lee, Jasme, additional, Elko, Theresa A., additional, Levy, Lauren, additional, Preston, Elaina, additional, Devlin, Sean M., additional, Ponce, Doris M., additional, Lin, Richard J., additional, Shaffer, Brian C., additional, Cho, Christina, additional, Politikos, Ioannis, additional, Jakubowski, Ann A., additional, Park, Jae H., additional, Rampal, Raajit, additional, Perales, Miguel‐Angel, additional, Tallman, Martin S., additional, Barker, Juliet N., additional, Berman, Ellin, additional, Tamari, Roni, additional, Stein, Eytan, additional, Giralt, Sergio A., additional, and Gyurkocza, Boglarka, additional

Published
2023
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49. The Simplified Comorbidity Index predicts non‐relapse mortality in reduced‐intensity conditioning allogeneic haematopoietic cell transplantation

Author

Elias, Shlomo, primary, Brown, Samantha, additional, Devlin, Sean M., additional, Barker, Juliet N., additional, Cho, Christina, additional, Chung, David J., additional, Dahi, Parastoo B., additional, Giralt, Sergio, additional, Gyurkocza, Boglarka, additional, Jakubowski, Ann A., additional, Lahoud, Oscar B., additional, Landau, Heather, additional, Lin, Richard J., additional, Papadopoulos, Esperanza B., additional, Politikos, Ioannis, additional, Ponce, Doris M., additional, Scordo, Michael, additional, Shaffer, Brian C., additional, Shah, Gunjan L., additional, Tamari, Roni, additional, Young, James W., additional, Perales, Miguel‐Angel, additional, and Shouval, Roni, additional

Published
2023
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50. A Chemotherapy-Only Regimen of Busulfan, Melphalan, and Fludarabine, and Rabbit Antithymocyte Globulin Followed by Allogeneic T-Cell Depleted Hematopoietic Stem Cell Transplantations for the Treatment of Myeloid Malignancies

Author

Spitzer, Barbara, Jakubowski, Ann A., Papadopoulos, Esperanza B., Fuller, Kirsten, Hilden, Patrick D., Young, James W., Barker, Juliet N., Koehne, Guenther, Perales, Miguel-Angel, Hsu, Katharine C., van den Brink, Marcel R., Kernan, Nancy A., Prockop, Susan E., Scaradavou, Andromachi, Castro-Malaspina, Hugo, O'Reilly, Richard J., and Boulad, Farid

Published
2017
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