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31 results on '"Jakovski, Zlatko"'

1. Advancing Patient Safety: The Future of Artificial Intelligence in Mitigating Healthcare-Associated Infections: A Systematic Review.

Author

Radaelli, Davide, Di Maria, Stefano, Jakovski, Zlatko, Alempijevic, Djordje, Al-Habash, Ibrahim, Concato, Monica, Bolcato, Matteo, and D'Errico, Stefano

Subjects
PNEUMONIA prevention, NOSOCOMIAL infection prevention, CROSS infection prevention, URINARY tract infection prevention, PUBLIC health surveillance, COST control, PATIENT safety, CROSS infection, PERSONAL protective equipment, ARTIFICIAL intelligence, NATURAL language processing, SYSTEMATIC reviews, MEDLINE, QUALITY assurance, ONLINE information services, SURGICAL site infections, MACHINE learning, ALGORITHMS, EMPLOYEES' workload, SENSITIVITY & specificity (Statistics)
Abstract

Background: Healthcare-associated infections are infections that patients acquire during hospitalization or while receiving healthcare in other facilities. They represent the most frequent negative outcome in healthcare, can be entirely prevented, and pose a burden in terms of financial and human costs. With the development of new AI and ML algorithms, hospitals could develop new and automated surveillance and prevention models for HAIs, leading to improved patient safety. The aim of this review is to systematically retrieve, collect, and summarize all available information on the application and impact of AI in HAI surveillance and/or prevention. Methods: We conducted a systematic review of the literature using PubMed and Scopus to find articles related to the implementation of artificial intelligence in the surveillance and/or prevention of HAIs. Results: We identified a total of 218 articles, of which only 35 were included in the review. Most studies were conducted in the US (n = 10, 28.6%) and China (n = 5; 14.3%) and were published between 2021 and 2023 (26 articles, 74.3%) with an increasing trend over time. Most focused on the development of ML algorithms for the identification/prevention of surgical site infections (n = 18; 51%), followed by HAIs in general (n = 9; 26%), hospital-acquired urinary tract infections (n = 5; 9%), and healthcare-associated pneumonia (n = 3; 9%). Only one study focused on the proper use of personal protective equipment (PPE) and included healthcare workers as the study population. Overall, the trend indicates that several AI/ML models can effectively assist clinicians in everyday decisions, by identifying HAIs early or preventing them through personalized risk factors with good performance. However, only a few studies have reported an actual implementation of these models, which proved highly successful. In one case, manual workload was reduced by nearly 85%, while another study observed a decrease in the local hospital's HAI incidence from 1.31% to 0.58%. Conclusions: AI has significant potential to improve the prevention, diagnosis, and management of healthcare-associated infections, offering benefits such as increased accuracy, reduced workloads, and cost savings. Although some AI applications have already been tested and validated, adoption in healthcare is hindered by barriers such as high implementation costs, technological limitations, and resistance from healthcare workers. Overcoming these challenges could allow AI to be more widely and cost-effectively integrated, ultimately improving patient care and infection management. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Comparative Toxicological Analyses of Traditional Matrices and Blow Fly Larvae in Four Cases of Highly Decomposed Human Cadavers.

Author

Peruch, Michela, Buffon, Maria, Jakovski, Zlatko, Spiliopoulou, Chara, Addobbati, Riccardo, Franzin, Martina, Magni, Paola A., and D'Errico, Stefano

Subjects
FORENSIC sciences, DRUG metabolism, CRIME scenes, CAUSES of death, INSECT collection & preservation
Abstract

Simple Summary: Determining the time and cause of death in forensic investigations is challenging when remains are highly decomposed, making traditional toxicological samples unreliable. Entomotoxicology, a controversial and underinvestigated field in forensic science, uses insect specimens from cadavers as alternative toxicological samples. Research has shown that insects feeding on decomposing tissues can serve as substrate for toxicological analyses, which can detect drugs, toxins, and elements even at low concentrations. Nevertheless, the correlation of drug concentrations between insects and conventional matrices is controversial due to unknown factors affecting drug metabolism. This paper examines four real cases where human cadavers were in advanced decomposition, and toxicological analyses were performed on both insect samples and available matrices. The findings provide insights into the correlation between larvae and human specimen results, adding to the limited literature on entomotoxicology in real cases. Additionally, this paper offers guidelines for collecting and preserving entomological evidence at crime scenes and during autopsies for use in entomotoxicological analyses. This advancement shows promise in enhancing forensic investigations, particularly in cases where traditional methods are inapplicable or require additional validation. In forensic investigation, determining the time and cause of death becomes challenging, especially in cases where the remains are found in advanced decomposition, rendering traditional toxicological samples unavailable or unreliable. Entomotoxicology, an emerging methodology within forensic science, leverages insect specimens collected from cadavers as alternative toxicological samples. Several laboratory and field research studies have highlighted the efficacy in detecting various drugs, toxins, and elements absorbed by insects feeding on cadaveric tissues, even at low concentrations. However, correlation studies between drug concentrations in conventional matrices and insects remain controversial due to unknown factors influencing drug metabolism and larval feeding activity. This paper presents four real cases in which human cadavers were discovered in advanced stages of decomposition, and toxicological analyses were performed on both insect samples and available matrices. The results presented complement the scant literature currently available on the application of entomotoxicology in real cases, providing insights into the correlation between larvae and human specimen results. Furthermore, guidelines to collect and preserve entomological evidence at the crime scene and during the autopsy for use in entomotoxicological analyses are provided. This advancement holds promise in aiding forensic investigations, particularly in cases where traditional methods cannot be applied or require supporting data for further validation. [ABSTRACT FROM AUTHOR]

Published
2024
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10. A global analysis of Y-chromosomal haplotype diversity for 23 STR loci

Author

Purps, Josephine, Siegert, Sabine, Willuweit, Sascha, Nagy, Marion, Alves, Cíntia, Salazar, Renato, Angustia, Sheila M.T., Santos, Lorna H., Anslinger, Katja, Bayer, Birgit, Ayub, Qasim, Wei, Wei, Xue, Yali, Tyler-Smith, Chris, Bafalluy, Miriam Baeta, Martínez-Jarreta, Begoña, Egyed, Balazs, Balitzki, Beate, Tschumi, Sibylle, Ballard, David, Court, Denise Syndercombe, Barrantes, Xinia, Bäßler, Gerhard, Wiest, Tina, Berger, Burkhard, Niederstätter, Harald, Parson, Walther, Davis, Carey, Budowle, Bruce, Burri, Helen, Borer, Urs, Koller, Christoph, Carvalho, Elizeu F., Domingues, Patricia M., Chamoun, Wafaa Takash, Coble, Michael D., Hill, Carolyn R., Corach, Daniel, Caputo, Mariela, D’Amato, Maria E., Davison, Sean, Decorte, Ronny, Larmuseau, Maarten H.D., Ottoni, Claudio, Rickards, Olga, Lu, Di, Jiang, Chengtao, Dobosz, Tadeusz, Jonkisz, Anna, Frank, William E., Furac, Ivana, Gehrig, Christian, Castella, Vincent, Grskovic, Branka, Haas, Cordula, Wobst, Jana, Hadzic, Gavrilo, Drobnic, Katja, Honda, Katsuya, Hou, Yiping, Zhou, Di, Li, Yan, Hu, Shengping, Chen, Shenglan, Immel, Uta-Dorothee, Lessig, Rüdiger, Jakovski, Zlatko, Ilievska, Tanja, Klann, Anja E., García, Cristina Cano, de Knijff, Peter, Kraaijenbrink, Thirsa, Kondili, Aikaterini, Miniati, Penelope, Vouropoulou, Maria, Kovacevic, Lejla, Marjanovic, Damir, Lindner, Iris, Mansour, Issam, Al-Azem, Mouayyad, Andari, Ansar El, Marino, Miguel, Furfuro, Sandra, Locarno, Laura, Martín, Pablo, Luque, Gracia M., Alonso, Antonio, Miranda, Luís Souto, Moreira, Helena, Mizuno, Natsuko, Iwashima, Yasuki, Neto, Rodrigo S. Moura, Nogueira, Tatiana L.S., Silva, Rosane, Nastainczyk-Wulf, Marina, Edelmann, Jeanett, Kohl, Michael, Nie, Shengjie, Wang, Xianping, Cheng, Baowen, Núñez, Carolina, Pancorbo, Marian Martínez de, Olofsson, Jill K., Morling, Niels, Onofri, Valerio, Tagliabracci, Adriano, Pamjav, Horolma, Volgyi, Antonia, Barany, Gusztav, Pawlowski, Ryszard, Maciejewska, Agnieszka, Pelotti, Susi, Pepinski, Witold, Abreu-Glowacka, Monica, Phillips, Christopher, Cárdenas, Jorge, Rey-Gonzalez, Danel, Salas, Antonio, Brisighelli, Francesca, Capelli, Cristian, Toscanini, Ulises, Piccinini, Andrea, Piglionica, Marilidia, Baldassarra, Stefania L., Ploski, Rafal, Konarzewska, Magdalena, Jastrzebska, Emila, Robino, Carlo, Sajantila, Antti, Palo, Jukka U., Guevara, Evelyn, Salvador, Jazelyn, Ungria, Maria Corazon De, Rodriguez, Jae Joseph Russell, Schmidt, Ulrike, Schlauderer, Nicola, Saukko, Pekka, Schneider, Peter M., Sirker, Miriam, Shin, Kyoung-Jin, Oh, Yu Na, Skitsa, Iulia, Ampati, Alexandra, Smith, Tobi-Gail, Calvit, Lina Solis de, Stenzl, Vlastimil, Capal, Thomas, Tillmar, Andreas, Nilsson, Helena, Turrina, Stefania, De Leo, Domenico, Verzeletti, Andrea, Cortellini, Venusia, Wetton, Jon H., Gwynne, Gareth M., Jobling, Mark A., Whittle, Martin R., Sumita, Denilce R., Wolańska-Nowak, Paulina, Yong, Rita Y.Y., Krawczak, Michael, Nothnagel, Michael, and Roewer, Lutz

Published
2014
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17. A comprehensive mutation study in wide deep-rooted R1 b Serbian pedigree: mutation rates and male relative differentiation capacity of 36 Y-STR markers

Author

Čokić, Vladan, Čokić, Vladan, Kecmanović, Miljana, Zgonjanin-Bosić, Dragana, Jakovski, Zlatko, Veljković, Aleksandar, Katić, Srđan, Keckarevic-Marković, Milica, Keckarević, Dusan, Čokić, Vladan, Čokić, Vladan, Kecmanović, Miljana, Zgonjanin-Bosić, Dragana, Jakovski, Zlatko, Veljković, Aleksandar, Katić, Srđan, Keckarevic-Marković, Milica, and Keckarević, Dusan

Abstract

Haplotyping of Y-chromosomal short tandem repeats (Y-STRs) reflects the paternal lineage, although, the father-son pair profiles may differ due to the germline mutations. In order to discriminate between closely related males in criminal cases, as well as for the correct application of Y-STRs in the paternity/kinship analysis and determination of the most recent common ancestor in the familial searching or genealogy research, the assessment of mutation rates of routinely used Y-STRs is of a great importance. We genotyped 120 males belonging to one wide deep-rooted pedigree separated by 1-20 meiosis. The haplotypes of analyzed males distributed over 12 different families (according to their surnames), with 113 originating from one ancestor, and the remaining 7 from the second, closely related to the previous one, belong to the Rlb haplogroup. The analysis was performed using Powerplex (R) Y23 kit, Yfiler (TM) plus kit and 13 rapidly mutating (RM13) Y-STRs. In 20,855 allele transmissions, 175 mutations (61% repeat losses and 39% gains) and one gene conversion event were found at 25 out of 36 markers. The medians of locus-specific mutation rates estimated using the Bayesian approach ranged from 1.42 x 10 (-3) (95% credible interval (CI): 0.05 x 10(-3)- 7.56 x 10(-3)) for loci with no observed mutations to 130.91 x 10(-3) (95% CI: 102.91 x 10(-3) - 162.78 x 10(-3)) for DYF399S1, with a median rate across all 36 markers of 10.06 x 10(-3) (95% CI: 8.65 x 10(-3)- 11.61 x 10(-3)). In 6349 male relative pairs, the 36 Y-STR set distinguished 98.4% relative pairs by at least one mutation, compared to 95.9%, 65.5% and 57.4% for RM13, Yfiler (TM) plus, and Powerplex (R) Y23 set, respectively. The extra-pair paternity rate was estimated at 11.9 x 10(-3) (95% CI: 4.4 x 10(-3)- 25.8 x 10(-3)) fitting within the range reported for some European populations. A significant positive correlation was observed between fathers' ages at the time of the Y chromosome transmission and mutabili

Published
2019

18. Population Analysis of the ESS Loci and SE33 Locus in a Republica of Serbia

Author

Jakovski, Zlatko, Keckarević, Dušan, Dogan, Serkan, Jankova Ajanovska, Renata, Keckarović- Marković, R, and Marjanović, Damir

Subjects
Serbia, population data, European standard set (ESS), ESI 17, comparative statistics
Abstract

In previous population studies of Serbian human population, 15 STR loci included in the Identifiler were used. For further development of this dataset, we analyzed the new ESS loci and the SE33 locus. We tested 197 unrelated healthy individuals born in Serbia. Qiagen MicroTM Tissue Kit was used for DNA extraction from whole blood, Quantifiler assay for quantification and PowerPlex ESI 17 System for amplification and detection. Electrophoresis of the amplification products was preformed on an ABI PRISM 310. Numerical allele designations of the profiles were obtained by processing with Gene Mapper1 IDv 3.2 Software. Arlequin software, version 3.5.1.2, was used to calculate allele frequencies, observed heterozygosity (Ho), expected heterozygosity (He) and Pvalues of the Hardy-Weinberg equilibrium (HWE). Also, the same software was used for the exact population differentiation tests using allele frequencies. Matching probability (MP), power of discrimination (PD), polymorphism information content (PIC), probability of exclusion (PE) and typical paternity index (TPI) were determined by Powerstats, version 1.2. No statistically significant deviation (p < 0.05) from HWE was found, except for the D2S441 locus (0.0306), which was rejected after Bonferroni correction. Also, we have compared Serbian data with the data obtained from geographically closer (neighboring) European populations. Nei’s genetic distances among 10 European populations including this study were computed and a NJphylogenetic tree of 5 ESS STR loci for compared populations was built. It could be seen that, even using only 6 STR loci, “neighboring clustering” of the data could be recognized.

Published
2015

21. Mitochondrial DNA control region analysis of three ethnic groups in the Republic of Macedonia

Author

Jankova-Ajanovska, Renata, Zimmermann, Bettina, Huber, Gabriela, Röck, Alexander W., Bodner, Martin, Jakovski, Zlatko, Janeska, Biljana, Duma, Aleksej, and Parson, Walther

Subjects
Albanians, mtDNA, Short Communication, Romanies, DNA, Mitochondrial, Polymerase Chain Reaction, Republic of North Macedonia, Pathology and Forensic Medicine, Genetics, Population, Haplotypes, Turks, Genetics, Ethnicity, Haplogroups, Humans, EMPOP
Abstract

A total of 444 individuals representing three ethnic groups (Albanians, Turks and Romanies) in the Republic of Macedonia were sequenced in the mitochondrial control region. The mtDNA haplogroup composition differed between the three groups. Our results showed relatively high frequencies of haplogroup H12 in Albanians (8.8%) and less in Turks (3.3%), while haplogroups M5a1 and H7a1a were dominant in Romanies (13.7% and 10.3%, respectively) but rare in the former two. This highlights the importance of regional sampling for forensic mtDNA databasing purposes. These population data will be available on EMPOP under accession numbers EMP00644 (Albanians), EMP00645 (Romanies) and EMP00646 (Turks).

Published
2014

22. Standing at the Gateway to Europe - The Genetic Structure of Western Balkan Populations Based on Autosomal and Haploid Markers

Author

Kovacevic, Lejla, Tambets, Kristiina, Ilumaee, Anne-Mai, Kushniarevich, Alena, Yunusbayev, Bayazit, Solnik, Anu, Bego, Tamer, Primorac, Dragan, Skaro, Vedrana, Leskovac, Andreja, Jakovski, Zlatko, Drobnic, Katja, Tolk, Helle-Viivi, Kovacevic, Sandra, Rudan, Pavao, Metspalu, Ene, Marjanović, Damir, Kovacevic, Lejla, Tambets, Kristiina, Ilumaee, Anne-Mai, Kushniarevich, Alena, Yunusbayev, Bayazit, Solnik, Anu, Bego, Tamer, Primorac, Dragan, Skaro, Vedrana, Leskovac, Andreja, Jakovski, Zlatko, Drobnic, Katja, Tolk, Helle-Viivi, Kovacevic, Sandra, Rudan, Pavao, Metspalu, Ene, and Marjanović, Damir

Abstract

Contemporary inhabitants of the Balkan Peninsula belong to several ethnic groups of diverse cultural background. In this study, three ethnic groups from Bosnia and Herzegovina - Bosniacs, Bosnian Croats and Bosnian Serbs - as well as the populations of Serbians, Croatians, Macedonians from the former Yugoslav Republic of Macedonia, Montenegrins and Kosovars have been characterized for the genetic variation of 660 000 genome-wide autosomal single nucleotide polymorphisms and for haploid markers. New autosomal data of the 70 individuals together with previously published data of 20 individuals from the populations of the Western Balkan region in a context of 695 samples of global range have been analysed. Comparison of the variation data of autosomal and haploid lineages of the studied Western Balkan populations reveals a concordance of the data in both sets and the genetic uniformity of the studied populations, especially of Western South-Slavic speakers. The genetic variation of Western Balkan populations reveals the continuity between the Middle East and Europe via the Balkan region and supports the scenario that one of the major routes of ancient gene flows and admixture went through the Balkan Peninsula.

Published
2014

25. ALLELE FREQUENCIES OF 17 STR Y CHROMOSOME LOCI IN THE POPULATION OF REBUBLIC OF MACEDONIA

Author

Jakovski, Zlatko, Nikolova, K, Jankova, R, Janeska, B, Marjanović Damir, and Aleksej D

Subjects
Y chromosome STR, Macedonian Population, Frequencies, Statistic, Comaparative
Abstract

Allele frequencies of 17 STR loci (DYS19, DYS189I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385I/II, DYS438, DYS439, DYS437, DYS448, DYS456, DYS458, DYS635 and Y GATA H4) were determined in a sample of 100 unrelated individuals from the Republic of Macedonia. AmpFISTRYFiler Kit (Applied Biosystems) was used for PCR amplification. Allele frequencies of these loci have been compared with data obtained from geographically close European populations (Serbia, Kosovo, Bulgaria, Bosnia and Herzegovina and coastal part of Croatia). The significance level after Bonferroni’ s correction was considered as p

Published
2007

26. Standing at the Gateway to Europe - The Genetic Structure of Western Balkan Populations Based on Autosomal and Haploid Markers

Author

Kovacevic, Lejla, primary, Tambets, Kristiina, additional, Ilumäe, Anne-Mai, additional, Kushniarevich, Alena, additional, Yunusbayev, Bayazit, additional, Solnik, Anu, additional, Bego, Tamer, additional, Primorac, Dragan, additional, Skaro, Vedrana, additional, Leskovac, Andreja, additional, Jakovski, Zlatko, additional, Drobnic, Katja, additional, Tolk, Helle-Viivi, additional, Kovacevic, Sandra, additional, Rudan, Pavao, additional, Metspalu, Ene, additional, and Marjanovic, Damir, additional

Published
2014
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27. Reliable and durable Golgi staining of brain tissue from human autopsies and experimental animals

Author

Rosoklija, Gorazd B., primary, Petrushevski, Vladimir M., additional, Stankov, Aleksandar, additional, Dika, Ani, additional, Jakovski, Zlatko, additional, Pavlovski, Goran, additional, Davcheva, Natasha, additional, Lipkin, Richard, additional, Schnieder, Tatiana, additional, Scobie, Kimberley, additional, Duma, Aleksej, additional, and Dwork, Andrew J., additional

Published
2014
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28. Identification of human remains from the plane crash

Author

Kubat, Milovan, Furač, Ivana, Masić, Marijana, Jakovski, Zlatko, Nikolova, Ksenija, Karija, Monika, Vlahović, Slavica, Marketin Raguž, Ivona, Duma, Aleksej, and Skavić, Josip

Subjects
identification, human remains
Published
2003

29. Forensic DNA databases in Western Balkan region: retrospectives, perspectives, and initiatives

Author

Marjanović, Damir, primary, Konjhodžić, Rijad, additional, Butorac, Sara Sanela, additional, Drobnič, Katja, additional, Merkaš, Siniša, additional, Lauc, Gordan, additional, Primorac, Damir, additional, Anđelinović, Šimun, additional, Milosavljević, Mladen, additional, Karan, Željko, additional, Vidović, Stojko, additional, Stojković, Oliver, additional, Panić, Bojana, additional, Vučetić Dragović, Anđelka, additional, Kovačević, Sandra, additional, Jakovski, Zlatko, additional, Asplen, Chris, additional, and Primorac, Dragan, additional

Published
2011
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30. Forensic DNA databases in Western Balkan region: retrospectives, perspectives, and initiatives.

Author

Marjanovią, Damir, Konjhodžić, Rijad, Butorac, Sara Sanela, Drobnič, Katja, Merkaš, Siniša, Lauc, Gordan, Primorac, Damir, Anđelinović, Šimun, Milosavljević, Mladen, Karan, ſeljko, Vidović, Stojko, Stojković, Oliver, Panić, Bojana, Dragović, Anđelka Vuჟetić, Kovačević, Sandra, Jakovski, Zlatko, Asplen, Chris, and Primorac, Dragan

Subjects
*DNA data banks, *INSTITUTIONAL repositories, *FORENSIC sciences, *DNA
Abstract

The European Network of Forensic Science Institutes (ENFSI) recommended the establishment of forensic DNA databases and specific implementation and management legislations for all EU/ENFSI members. Therefore, forensic institutions from Bosnia and Herzegovina, Serbia, Montenegro, and Macedonia launched a wide set of activities to support these recommendations. To assess the current state, a regional expert team completed detailed screening and investigation of the existing forensic DNA data repositories and associated legislation in these countries. The scope also included relevant concurrent projects and a wide spectrum of different activities in relation to forensics DNA use. The state of forensic DNA analysis was also determined in the neighboring Slovenia and Croatia, which already have functional national DNA databases. There is a need for a 'regional supplement' to the current documentation and standards pertaining to forensic application of DNA databases, which should include regional-specific preliminary aims and recommendations. [ABSTRACT FROM AUTHOR]

Published
2011
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31. A global analysis of Y-chromosomal haplotype diversity for 23 STR loci

Author

Thomas Capal, Marian M. de Pancorbo, Birgit Bayer, Sheila M.T. Angustia, Francesca Brisighelli, Andrea Piccinini, Lutz Roewer, Yali Xue, Aikaterini Kondili, Alexandra Ampati, Katja Anslinger, Mouayyad Al-Azem, Witold Pepinski, Harald Niederstätter, Jae Joseph Russell B. Rodriguez, Katja Drobnič, Denise Syndercombe Court, Jana Wobst, David Ballard, Danel Rey-González, Marina Nastainczyk-Wulf, Christopher Phillips, Magdalena Konarzewska, Evelyn K. Guevara, Jill K. Olofsson, Maria Eugenia D’Amato, Natsuko Mizuno, Ansar El Andari, Yiping Hou, G.M. Luque, Carolyn R. Hill, Antti Sajantila, Cordula Haas, Tobi Gail Smith, Christian Gehrig, Andreas O. Tillmar, Marilidia Piglionica, Anja E. Klann, M. Sirker, Jazelyn M. Salvador, Jukka U. Palo, Rita Y.Y. Yong, Antonio Alonso, Xinia Barrantes, Bruce Budowle, Helen Burri, Xianping Wang, Baowen Cheng, Paulina Wolańska-Nowak, Peter de Knijff, Renato Salazar, Thirsa Kraaijenbrink, Shenglan Chen, Susi Pelotti, Tatiana Lúcia Santos Nogueira, Mark A. Jobling, Iulia Skitsa, Issam Mansour, Jeanett Edelmann, Urs V. Borer, Stefania Lonero Baldassarra, Maria Corazon A. De Ungria, Di Zhou, William E. Frank, Jon H. Wetton, Begoña Martínez-Jarreta, Sheng-Ping Hu, Marion Nagy, Andrea Verzeletti, Rodrigo Soares de Moura Neto, Martin R. Whittle, Anna Jonkisz, Ryszard Pawłowski, Cristian Capelli, Yu Na Oh, Emila Jastrzebska, Helena Nilsson, Agnieszka Maciejewska, M. Kohl, Cristina Cano García, Miguel Marino, Michael D. Coble, Elizeu Fagundes de Carvalho, Gareth M. Gwynne, Michael Nothnagel, Chengtao Jiang, Tadeusz Dobosz, Gavrilo Hadzic, Burkhard Berger, Sascha Willuweit, Branka Grskovic, Katsuya Honda, Tanja Ilievska, Rüdiger Lessig, Zlatko Jakovski, Antonio Salas, Balázs Egyed, Laura Locarno, Christoph Koller, Helena Moreira, Sibylle Tschumi, Carolina Núñez, Luís Souto Miranda, Nicola Schlauderer, Patrícia Domingues, Yasuki Iwashima, Di Lu, V. Cortellini, Antónia Völgyi, Monica Abreu-Głowacka, Mariela Caputo, Maarten Larmuseau, Peter M. Schneider, Wafaa Takash Chamoun, Gerhard Bäßler, Pekka Saukko, Cíntia Alves, Lejla Kovacevic, Maria Vouropoulou, Walther Parson, Stefania Turrina, Chris Tyler-Smith, Lina Solis De Calvit, D.R. Sumita, Qasim Ayub, T. Wiest, Iris Lindner, Jorge Cárdenas, Kyoung Jin Shin, Daniel Corach, Claudio Ottoni, Carlo Robino, Sabine Siegert, Ivana Furač, Miriam Baeta Bafalluy, Uta Dorothee Immel, Domenico De Leo, Ronny Decorte, Sandra Furfuro, Niels Morling, Valerio Onofri, Adriano Tagliabracci, Rosane Silva, Beate Balitzki, Ulises Toscanini, Olga Rickards, Michael Krawczak, Sean Davison, Ulrike Schmidt, Wei Wei, Pablo Martín, Vincent Castella, Yan Li, P. Miniati, Rafał Płoski, Gusztáv Bárány, Vlastimil Stenzl, Shengjie Nie, Horolma Pamjav, Carey Davis, Josephine Purps, Lorna H. Santos, Damir Marjanović, Hjelt Institute (-2014), Forensic Medicine, PaleOmics Laboratory, Purps, Josephine, Siegert, Sabine, Willuweit, Sascha, Nagy, Marion, Alves, Cíntia, Salazar, Renato, Angustia, Sheila M.T., Santos, Lorna H., Anslinger, Katja, Bayer, Birgit, Ayub, Qasim, Wei, Wei, Xue, Yali, Tyler-Smith, Chri, Bafalluy, Miriam Baeta, Martínez-Jarreta, Begoña, Egyed, Balaz, Balitzki, Beate, Tschumi, Sibylle, Ballard, David, Court, Denise Syndercombe, Barrantes, Xinia, Bäßler, Gerhard, Wiest, Tina, Berger, Burkhard, Niederstätter, Harald, Parson, Walther, Davis, Carey, Budowle, Bruce, Burri, Helen, Borer, Ur, Koller, Christoph, Carvalho, Elizeu F., Domingues, Patricia M., Chamoun, Wafaa Takash, Coble, Michael D., Hill, Carolyn R., Corach, Daniel, Caputo, Mariela, D'Amato, Maria E., Davison, Sean, Decorte, Ronny, Larmuseau, Maarten H.D., Ottoni, Claudio, Rickards, Olga, Lu, Di, Jiang, Chengtao, Dobosz, Tadeusz, Jonkisz, Anna, Frank, William E., Furac, Ivana, Gehrig, Christian, Castella, Vincent, Grskovic, Branka, Haas, Cordula, Wobst, Jana, Hadzic, Gavrilo, Drobnic, Katja, Honda, Katsuya, Hou, Yiping, Zhou, Di, Li, Yan, Hu, Shengping, Chen, Shenglan, Immel, Uta-Dorothee, Lessig, Rüdiger, Jakovski, Zlatko, Ilievska, Tanja, Klann, Anja E., García, Cristina Cano, De Knijff, Peter, Kraaijenbrink, Thirsa, Kondili, Aikaterini, Miniati, Penelope, Vouropoulou, Maria, Kovacevic, Lejla, Marjanovic, Damir, Lindner, Iri, Mansour, Issam, Al-Azem, Mouayyad, Andari, Ansar El, Marino, Miguel, Furfuro, Sandra, Locarno, Laura, Martín, Pablo, Luque, Gracia M., Alonso, Antonio, Miranda, Luís Souto, Moreira, Helena, Mizuno, Natsuko, Iwashima, Yasuki, Neto, Rodrigo S. Moura, Nogueira, Tatiana L.S., Silva, Rosane, Nastainczyk-Wulf, Marina, Edelmann, Jeanett, Kohl, Michael, Nie, Shengjie, Wang, Xianping, Cheng, Baowen, Núñez, Carolina, Pancorbo, Marian Martínez De, Olofsson, Jill K., Morling, Niel, Onofri, Valerio, Tagliabracci, Adriano, Pamjav, Horolma, Volgyi, Antonia, Barany, Gusztav, Pawlowski, Ryszard, Maciejewska, Agnieszka, Pelotti, Susi, Pepinski, Witold, Abreu-Glowacka, Monica, Phillips, Christopher, Cárdenas, Jorge, Rey-Gonzalez, Danel, Salas, Antonio, Brisighelli, Francesca, Capelli, Cristian, Toscanini, Ulise, Piccinini, Andrea, Piglionica, Marilidia, Baldassarra, Stefania L., Ploski, Rafal, Konarzewska, Magdalena, Jastrzebska, Emila, Robino, Carlo, Sajantila, Antti, Palo, Jukka U., Guevara, Evelyn, Salvador, Jazelyn, Ungria, Maria Corazon De, Rodriguez, Jae Joseph Russell, Schmidt, Ulrike, Schlauderer, Nicola, Saukko, Pekka, Schneider, Peter M., Sirker, Miriam, Shin, Kyoung-Jin, Oh, Yu Na, Skitsa, Iulia, Ampati, Alexandra, Smith, Tobi-Gail, Calvit, Lina Solis De, Stenzl, Vlastimil, Capal, Thoma, Tillmar, Andrea, Nilsson, Helena, Turrina, Stefania, De Leo, Domenico, Verzeletti, Andrea, Cortellini, Venusia, Wetton, Jon H., Gwynne, Gareth M., Jobling, Mark A., Whittle, Martin R., Sumita, Denilce R., Wolańska-Nowak, Paulina, Yong, Rita Y.Y., Krawczak, Michael, Nothnagel, Michael, and Roewer, Lutz

Subjects
Forensic Genetics, Population structure, RECOMBINATION, Forensic Genetic, purl.org/becyt/ford/1 [https], AMOVA, Database, Discriminatory power, Gene diversity, Population structure, Genética y Herencia, 0302 clinical medicine, MARKERS, Haplotype, POPULATION, Allele, Genetics, 0303 health sciences, education.field_of_study, Medicine (all), Gene diversity, 319 Forensic science and other medical sciences, 16. Peace & justice, Gene diversity, Discriminatory power, AMOVA, Population structure, Database, Str loci, Microsatellite Repeat, AMOVA, Database, Discriminatory power, Gene diversity, Population structure, Genetics, Forensic Medicine, ALLELE FREQUENCIES, Discriminatory power, CIENCIAS NATURALES Y EXACTAS, Human, AMOVA, Population, Settore BIO/08 - ANTROPOLOGIA, Biology, Settore BIO/08, SEQUENCE, Article, Pathology and Forensic Medicine, EVENTS, Ciencias Biológicas, Database, 03 medical and health sciences, Genetic, Settore MED/43 - Medicina Legale, Humans, 030216 legal & forensic medicine, education, purl.org/becyt/ford/1.6 [https], Allele frequency, Alleles, 030304 developmental biology, Chromosomes, Human, Y, ta1184, DELETION, Null (mathematics), AZFA REGION, ta3121, Haplotypes, 3111 Biomedicine, SYSTEM, Microsatellite Repeats
Abstract

In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) and using the PowerPlex Y23 System (PPY23, Promega Corporation, Madison, WI). Locus-specific allelic spectra of these markers were determined and a consistently high level of allelic diversity was observed. A considerable number of null, duplicate and off-ladder alleles were revealed. Standard single-locus and haplotype-based parameters were calculated and compared between subsets of Y-STR markers established for forensic casework. The PPY23 marker set provides substantially stronger discriminatory power than other available kits but at the same time reveals the same general patterns of population structure as other marker sets. A strong correlation was observed between the number of Y-STRs included in a marker set and some of the forensic parameters under study. Interestingly a weak but consistent trend toward smaller genetic distances resulting from larger numbers of markers became apparent. Fil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Caputo, Mariela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Marino, Miguel Eduardo. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Laboratorio de Analisis de ADN; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Purps, Josephine. Charité-Universitätsmedizin; Alemania Fil: Siegert, Sabine. University of Cologne; Alemania Fil: Willuweit, Sascha. Charité-Universitätsmedizin; Alemania Fil: Nagy, Marion. Charité-Universitätsmedizin; Alemania Fil: Alves, Cíntia. Universidad de Porto; Portugal Fil: Salazar, Renato. Universidad de Porto; Portugal Fil: Angustia, Sheila M. T.. Philippine National Police Crime Laboratory; Filipinas Fil: Santos, Lorna H.. Philippine National Police Crime Laboratory; Filipinas Fil: Anslinger, Katja. Universitat Genzentrum Der Ludwing-maximilians; Alemania Fil: Bayer, Birgit. Universitat Genzentrum Der Ludwing-maximilians; Alemania Fil: Ayub, Qasim. The Wellcome Trust Sanger Institute; Reino Unido Fil: Wei, Wei. The Wellcome Trust Sanger Institute; Reino Unido Fil: Xue, Yali. The Wellcome Trust Sanger Institute; Reino Unido Fil: Tyler Smith, Chris. The Wellcome Trust Sanger Institute; Reino Unido Fil: Baeta Bafalluy, Miriam. Universidad de Zaragoza; España Fil: Martínez Jarreta, Begoña. Universidad de Zaragoza; España Fil: Egyed, Balazs. Eotvos University, Budapest; Argentina Fil: Balitzki, Beate. Universidad de Basilea; Suiza Fil: Tschumi, Sibylle. Universidad de Basilea; Suiza Fil: Ballard, David. King; Reino Unido Fil: Syndercombe Court, Denise. King; Reino Unido Fil: Barrantes, Xinia. Poder Judicial, Forensic Sciences Department; Costa Rica Fil: Bäßler, Gerhard. Landeskriminalamt Baden-Württemberg; Alemania Fil: Berger, Burkhard. Universidad de Innsbruck; Austria Fil: Niederstätter, Haral. Universidad de Innsbruck; Austria Fil: Parson, Walther. Universidad de Innsbruck; Austria. University Park; Estados Unidos Fil: Davis, Carey. Department of Molecular and Medical Genetics; Estados Unidos. Institute of Applied Genetics; Estados Unidos Fil: Furfuro, Sandra. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Laboratorio de Análisis de ADN; Argentina Fil: Locarno, Laura. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Laboratorio de Análisis de ADN; Argentina

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