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1. Timing of radiotherapy (RT) after radical prostatectomy (RP): long-term outcomes in the RADICALS-RT trial (NCT00541047)

Author

Parker, C.C., Petersen, P.M., Cook, A.D., Clarke, N.W., Catton, C., Cross, W.R., Kynaston, H., Parulekar, W.R., Persad, R.A., Saad, F., Bower, L., Durkan, G.C., Logue, J., Maniatis, C., Noor, D., Payne, H., Anderson, J., Bahl, A.K., Bashir, F., Bottomley, D.M., Brasso, K., Capaldi, L., Chung, C., Cooke, P.W., Donohue, J.F., Eddy, B., Heath, C.M., Henderson, A., Henry, A., Jaganathan, R., Jakobsen, H., James, N.D., Joseph, J., Lees, K., Lester, J., Lindberg, H., Makar, A., Morris, S.L., Oommen, N., Ostler, P., Owen, L., Patel, P., Pope, A., Popert, R., Raman, R., Ramani, V., Røder, A., Sayers, I., Simms, M., Srinivasan, V., Sundaram, S., Tarver, K.L., Tran, A., Wells, P., Wilson, J., Zarkar, A.M., Parmar, M.K.B., and Sydes, M.R.

Published
2024
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2. OP0318-PARE IMPROVING CROSS-SECTORAL CARE FOR PATIENTS WITH INFLAMMATORY ARTHRITIS: RESULTS FROM A FIRST SEMINAR WITH CROSS-SECTORAL INVOLVEMENT

Author

Fabricius Petersen, B., primary, Christiansen, A. A., additional, Bremander, A., additional, Damgaard, A., additional, Frøhlich, K., additional, Kroeber, G., additional, Hoegh, N., additional, Jakobsen, H., additional, Knak, K., additional, Madsen, C. M. T., additional, Skov-Sørensen, K., additional, Primdahl, J., additional, Schreiber, K., additional, and Hendricks, O., additional

Published
2024
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3. Upfront resection versus no resection of the primary tumor in patients with synchronous metastatic colorectal cancer: the randomized phase III CAIRO4 study conducted by the Dutch Colorectal Cancer Group and the Danish Colorectal Cancer Group

Author

Medisch Oncologische Disciplines, MS Medische Oncologie, Hart- en Vaatziekten Team A, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, CTM & Statistical consultation, Epi Kanker Team B, Researchgr. Nucleaire Geneeskunde, Zorgeenheid Kinderchirurgie Medisch, MS CGO, van der Kruijssen, D. E.W., Elias, S. G., van de Ven, P. M., van Rooijen, K. L., Lam-Boer, J. ’t, Mol, L., Punt, C. J.A., Sommeijer, D. W., Tanis, P. J., Nielsen, J. D., Yilmaz, M. K., van Riel, J. M.G.H., Wasowiz-Kemps, D. K., Loosveld, O. J.L., van der Schelling, G. P., de Groot, J. W.B., van Westreenen, H. L., Jakobsen, H. L., Fromm, A. L., Hamberg, P., Verseveld, M., Jaensch, C., Liposits, G. I., van Duijvendijk, P., Oulad Hadj, J., van der Hoeven, J. A.B., Trajkovic, M., de Wilt, J. H.W., Koopman, M., van Grevenstein, W. M.U.Helma, CAIRO4 Working Group, Medisch Oncologische Disciplines, MS Medische Oncologie, Hart- en Vaatziekten Team A, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, CTM & Statistical consultation, Epi Kanker Team B, Researchgr. Nucleaire Geneeskunde, Zorgeenheid Kinderchirurgie Medisch, MS CGO, van der Kruijssen, D. E.W., Elias, S. G., van de Ven, P. M., van Rooijen, K. L., Lam-Boer, J. ’t, Mol, L., Punt, C. J.A., Sommeijer, D. W., Tanis, P. J., Nielsen, J. D., Yilmaz, M. K., van Riel, J. M.G.H., Wasowiz-Kemps, D. K., Loosveld, O. J.L., van der Schelling, G. P., de Groot, J. W.B., van Westreenen, H. L., Jakobsen, H. L., Fromm, A. L., Hamberg, P., Verseveld, M., Jaensch, C., Liposits, G. I., van Duijvendijk, P., Oulad Hadj, J., van der Hoeven, J. A.B., Trajkovic, M., de Wilt, J. H.W., Koopman, M., van Grevenstein, W. M.U.Helma, and CAIRO4 Working Group

Published
2024

4. Upfront resection versus no resection of the primary tumor in patients with synchronous metastatic colorectal cancer:the randomized phase III CAIRO4 study conducted by the Dutch Colorectal Cancer Group and the Danish Colorectal Cancer Group

Author

van der Kruijssen, D. E.W., Elias, S. G., van de Ven, P. M., van Rooijen, K. L., Lam-Boer, J. ’t, Mol, L., Punt, C. J.A., Sommeijer, D. W., Tanis, P. J., Nielsen, J. D., Yilmaz, M. K., van Riel, J. M.G.H., Wasowiz-Kemps, D. K., Loosveld, O. J.L., van der Schelling, G. P., de Groot, J. W.B., van Westreenen, H. L., Jakobsen, H. L., Fromm, A. L., Hamberg, P., Verseveld, M., Jaensch, C., Liposits, G. I., van Duijvendijk, P., Oulad Hadj, J., van der Hoeven, J. A.B., Trajkovic, M., de Wilt, J. H.W., Koopman, M., van der Kruijssen, D. E.W., Elias, S. G., van de Ven, P. M., van Rooijen, K. L., Lam-Boer, J. ’t, Mol, L., Punt, C. J.A., Sommeijer, D. W., Tanis, P. J., Nielsen, J. D., Yilmaz, M. K., van Riel, J. M.G.H., Wasowiz-Kemps, D. K., Loosveld, O. J.L., van der Schelling, G. P., de Groot, J. W.B., van Westreenen, H. L., Jakobsen, H. L., Fromm, A. L., Hamberg, P., Verseveld, M., Jaensch, C., Liposits, G. I., van Duijvendijk, P., Oulad Hadj, J., van der Hoeven, J. A.B., Trajkovic, M., de Wilt, J. H.W., and Koopman, M.

Abstract

Background: Upfront primary tumor resection (PTR) has been associated with longer overall survival (OS) in patients with synchronous unresectable metastatic colorectal cancer (mCRC) in retrospective analyses. The aim of the CAIRO4 study was to investigate whether the addition of upfront PTR to systemic therapy resulted in a survival benefit in patients with synchronous mCRC without severe symptoms of their primary tumor. Patients and methods: This randomized phase III trial was conducted in 45 hospitals in The Netherlands and Denmark. Eligibility criteria included previously untreated mCRC, unresectable metastases, and no severe symptoms of the primary tumor. Patients were randomized (1 : 1) to upfront PTR followed by systemic therapy or systemic therapy without upfront PTR. Systemic therapy consisted of first-line fluoropyrimidine-based chemotherapy with bevacizumab in both arms. Primary endpoint was OS in the intention-to-treat population. The study was registered at ClinicalTrials.gov, NCT01606098. Results: Between August 2012 and February 2021, 206 patients were randomized. In the intention-to-treat analysis, 204 patients were included (n = 103 without upfront PTR, n = 101 with upfront PTR) of whom 116 were men (57%) with median age of 65 years (interquartile range 59-71 years). Median follow-up was 69.4 months. Median OS in the arm without upfront PTR was 18.3 months (95% confidence interval 16.0-22.2 months) compared with 20.1 months (95% confidence interval 17.0-25.1 months) in the upfront PTR arm (P = 0.32). The number of grade 3-4 events was 71 (72%) in the arm without upfront PTR and 61 (65%) in the upfront PTR arm (P = 0.33). Three deaths (3%) possibly related to treatment were reported in the arm without upfront PTR and four (4%) in the upfront PTR arm. Conclusions: Addition of upfront PTR to palliative systemic therapy in patients with synchronous mCRC without severe symptom

Published
2024

6. Unitary Irreducible Representations of a Lie Algebra for Matrix Chain Models

Author

Jakobsen, H. P. and Lee, C. -W. H.

Subjects
Mathematical Physics, High Energy Physics - Theory, Mathematics - Representation Theory, 17B65
Abstract

There is a decomposition of a Lie algebra for open matrix chains akin to the triangular decomposition. We use this decomposition to construct unitary irreducible representations. All multiple meson states can be retrieved this way. Moreover, they are the only states with a finite number of non-zero quantum numbers with respect to a certain set of maximally commuting linearly independent quantum observables. Any other state is a tensor product of a multiple meson state and a state coming from a representation of a quotient algebra that extends and generalizes the Virasoro algebra. We expect the representation theory of this quotient algebra to describe physical systems at the thermodynamic limit., Comment: 46 pages, no figure; LaTeX2e, amssymb, latexsym; typos corrected

Published
2000
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14. The impact of stapling technique and surgeon specialism on anastomotic failure after right-sided colorectal resection: an international multicentre, prospective audit

Author

Glasbey, Jc, Nepogodiev, D, Battersby, N, Bhangu, A, El-Hussuna, A, Frasson, M, Singh, B, Vennix, S, Zmora, O, Pinkney, T, Chaudhri, S, Bemelman, W, Christensen, P, D'Hoore, A, Laurberg, S, Morton, D, Rubbini, M, Vaizey, C, Mehta, S, Ives, N, Magill, L, Perry, R, Sheward, N, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Salomon, M, Makhmudov, A, Selnyahina, L, Varabei, A, Vizhynis, Y, Claeys, D, Defoort, B, Muysoms, F, Pletinckx, P, Vergucht, V, Debergh, I, Feryn, T, Reusens, H, Nachtergaele, M, Francart, D, Jehaes, C, Markiewicz, S, Monami, B, Weerts, J, Bouckaert, W, Houben, B, Knol, J, Sergeant, G, Vangertruyden, G, Haeck, L, Lange, C, Sommeling, C, Vindevoghel, K, Castro, S, De Bruyn, H, Huyghe, M, De Wolf, E, Reynders, D, de Buck van Overstraeten, A, Wolthuis, A, Delibegovic, S, Christiani, A, Marchiori, M Jr, Rocha de Moraes, C, Tercioti, V Jr, Arabadjieva, E, Bulanov, D, Dardanov, D, Stoyanov, V, Yonkov, A, Angelov, K, Maslyankov, S, Sokolov, M, Todorov, G, Toshev, S, Georgiev, Y, Karashmalakov, A, Zafirov, G, Wang, X, Condic, D, Kraljik, D, Mrkovic, H, Pavkovic, V, Raguž, K, Bencurik, V, Holášková, E, Skrovina, M, Farkašová, M, Grolich, T, Kala, Z, Antos, F, Pruchova, V, Sotona, O, Chobola, M, Dusek, T, Ferko, A, Örhalmi, J, Hoch, J, Kocian, P, Martinek, L, Bernstein, I, Gotschalck Sunesen, K, Leunbach, J, Thorlacius-Ussing, O, Uth Oveson, A, Dahl Chirstensen, S, Gamez, V, Oeting, M, Schou Loeve, U, Ugianskis, A, Jessen, M, Krarup, P, Linde, K, Mirza, Q, Overgaard Stovring, J, Erritzøe, L, Loft Jakobsen, H, Lykke, J, Palmgren Colov, E, Husted Madsen, A, Linde Friis, T, Amstrup Funder, J, Dich, R, Kjaer, S, Rasmussen, S, Schlesinger, N, Dilling Kjaer, M, Qvist, N, Khalid, A, Ali, G, Hadi, S, Rosell Walker, L, Kivelä, A, Lehtonen, T, Lepistö, A, Scheinin, T, Siironen, P, Kössi, J, Kuusanmäki, P, Tomminen, T, Turunen, A, Rautio, T, Vierimaa, M, Huhtinen, H, Karvonen, J, Lavonius, M, Rantala, A, Varpe, P, Cotte, E, Francois, Y, Glehen, O, Kepenekian, V, Passot, G, Maggiori, L, Manceau, G, Panis, Y, Gout, M, Rullier, E, van Geluwe, B, Chafai, N, Lefevre, Jh, Parc, Y, Tiret, E, Couette, C, Duchalais, E, Agha, A, Hornberger, M, Hungbauer, A, Iesalnieks, I, Weindl, I, Crescenti, F, Keller, M, Kolodziejski, N, Scherer, R, Sterzing, D, Bock, B, Boehm, G, El-Magd, M, Krones, C, Niewiera, M, Buhr, J, Cordesmeyer, S, Hoffmann, M, Krückemeier, K, Vogel, T, Schön, M, Baral, J, Lukoschek, T, Münch, S, Pullig, F, Horisberger, K, Kienle, P, Magdeburg, J, Post, S, Batzalexis, K, Germanos, S, Agalianos, C, Dervenis, C, Gouvas, N, Kanavidis, P, Kottikias, A, Katsoulis, Ie, Korkolis, D, Plataniotis, G, Sakorafas, G, Akrida, I, Argentou, M, Kollatos, C, Lampropoulos, C, Tsochatzis, S, Besznyák, I, Bursics, A, Egyed, T, Papp, G, Svastics, I, Atladottir, J, Möller, P, Sigurdsson, H, Stefánsson, T, Valsdottir, E, Andrews, E, Foley, N, Hechtl, D, Majeed, M, Mccourt, M, Hanly, A, Hyland, J, Martin, S, O'Connell, Pr, Winter, D, Connelly, T, Joyce, W, Wrafter, P, Berkovitz, R, Avital, S, Haj Yahia, I, Hermann, N, Shpitz, B, White, I, Lishtzinsky, Y, Tsherniak, A, Wasserberg, N, Horesh, N, Keler, U, Pery, R, Shapiro, R, Tulchinsky, H, Badran, B, Dayan, K, Iskhakov, A, Lecaros, J, Nabih, N, Angrima, I, Bardini, R, Pizzolato, E, Tonello, M, Arces, F, Balestri, R, Ceccarelli, C, Prosperi, V, Rossi, E, Giannini, I, Vincenti, L, Di Candido, F, Di Iena, M, Guglielmi, A, Caputi-Iambrenghi, O, Marsanic, P, Mellano, A, Muratore, A, Annecchiarico, M, Bencini, L, Amore Bonapasta, S, Coratti, A, Guerra, F, Asteria, Cr, Boccia, L, Gerard, L, Pascariello, A, Manca, G, Marino, F, Casaril, A, Inama, M, Moretto, G, Bacchelli, C, Carvello, M, Mariani, N, Montorsi, M, Spinelli, A, Romairone, E, Scabini, S, Belli, A, Bianco, F, De Franciscis, S, Maria Romano, G, Delrio, P, Pace, U, Rega, D, Sassaroli, C, Scala, D, De Luca, R, Ruggieri, E, Elbetti, C, Garzi, A, Romoli, L, Scatizzi, M, Vannucchi, A, Curletti, G, Durante, V, Galleano, R, Mariani, F, Reggiani, L, Bellomo, R, Infantino, A, Franceschilli, L, Sileri, P, Clementi, I, Coletta, D, La Torre, F, Mingoli, A, Velluti, F, Di Giacomo, A, Fiorot, A, Massani, M, Padoan, L, Ruffolo, C, Caruso, S, Franceschini, F, Laessig, R, Monaci, I, Rontini, M, Annunziata Azienda SM, De Nardi, P, Elmore, U, Lemma, M, Rosati, R, Tamburini, A, De Luca, M, Sartori, A, Benevento, A, Bottini, C, Ferrari, Cc, Pata, F, Tessera, G, Pellino, G, Selvaggi, F, Lanzani, A, Romano, F, Sgroi, G, Steccanella, F, Turati, L, Yamamoto, T, Ancans, G, Gerkis, S, Leja, M, Pcolkins, A, Sivins, A, Latkauskas, T, Lizdenis, P, Saladžinskas, Ž, Švagždys, S, Tamelis, A, Razbadauskas, A, Sokolovas, M, Dulskas, A, Samalavicius, N, Jotautas, V, Mikalauskas, S, Poskus, E, Poskus, T, Strupas, K, Camenzuli, C, Cini, C, Predrag, A, Psaila, J, Spiteri, N, Buskens, C, de Groof EJ, Gooszen, J, Tanis, P, Belgers, E, Davids, P, Furnee, E, Postma, E, Pronk, A, Smakman, N, Clermonts, S, Zimmerman, D, Omloo, J, van der Zaag, E, van Duijvendijk, P, Wassenaar, E, Bruijninckx, M, de Graff, E, Doornebosch, P, Tetteroo, G, Vermaas, M, Iordens, G, Knops, S, Toorenvliet, B, van Westereenen HL, Boerma, E, Coene, P, van der Harst, E, Van Der Pool, A, Raber, M, Melenhorst, J, de Castro, S, Gerhards, M, Arron, M, Bremers, A, de Wilt, H, Ferenschild, F, Yauw, S, Cense, H, Demirkiran, A, Hunfeld, M, Mulder, I, Nonner, J, Swank, H, van Wagensveld, B, Bolmers, M, Briel, J, van Geloven, A, van Rossem, C, Klemann, V, Konsten, J, Leenders, B, Schok, T, Bleeker, W, Gidwani, A, Lawther, R, Loughlin, P, Skelly, B, Spence, R, Brun, M, Helgeland, M, Ignjatovic, D, Øresland, T, Yousefi, P, Flåten Backe, I, Helmer Sjo, O, Nesbakken, A, Tandberg-Eriksen, M, Cais, A, Hallvard Traeland, J, Herikstad, R, Kørner, H, Lauvland, N, Jajtner, D, Kabiesz, W, Rak, M, Gmerek, L, Horbacka, K, Horst, N, Krokowicz, P, Kwiatkowski, A, Pasnik, K, Karcz, P, Romaniszyn, M, Rusek, T, Walega, P, Czarencki, R, Obuszko, Z, Sitarska, M, Wojciech, W, Zawadzki, M, Amado, S, Clara, P, Couceiro, A, Malaquias, R, Rama, N, Almeida, A, Barbosa, E, Cernadas, E, Duarte, A, Silva, P, Costa, S, Martinez Insua, C, Marques, R, Pereira, J, Pereira, C, Sacchetti, M, Carvalho Pinto, B, Jorge Vieira Sousa, P, Oliveira, A, Cardoso, R, Carlos, S, Corte-Real, J, Moniz Pereira, P, Souto, R, Carneiro, C, Marinho, R, Nunes, V, Rocha, R, Sousa, M, Leite, J, Melo, F, Pimentel, J, Ventura, L, Vila Nova, C, Copăescu, C, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Domansky, N, Karachun, A, Moiseenko, A, Pelipas, Y, Petrov, A, Pravosudov, I, Aiupov, R, Akmalov, Y, Parfenov, A, Suleymanov, N, Tarasov, N, Jumabaev, H, Mamedli, Z, Rasulov, A, Aliev, I, Chernikovskiy, I, Kochnev, V, Komyak, K, Smirnov, A, Achkasov, S, Bolikhov, K, Shelygin, Y, Sushkov, O, Zapolskiy, A, Gvozdenovic, M, Jovanovic, D, Lausevic, Z, Cvetković, D, Maravić, M, Milovanovic, B, Stojakovic, N, Tripković, I, Mihajlovic, D, Nestorovic, M, Pecic, V, Petrovic, D, Stanojevic, G, Barisic, G, Dimitrijevic, I, Krivokapic, Z, Markovic, V, Popovic, M, Aleksic, A, Dabic, D, Kostic, I, Milojkovic, A, Perunicic, V, Lukic, D, Petrovic, T, Radovanovic, D, Radovanovic, Z, Cuk, Vm, Cuk, Vv, Kenic, M, Kovacevic, B, Krdzic, I, Korcek, J, Rems, M, Toplak, J, Escarrâ, J, Gil Barrionuevo, M, Golda, T, Kreisler Moreno, E, Zerpa Martin, C, Álvarez Laso, C, Cumplido, P, Padin, H, Baixauli Fons, J, Hernández-Lizoain, J, Martinez-Ortega, P, Molina-Fernández, M, Sánchez-Justicia, C, Antonio Gracia Solanas, J, Córdoba Díaz de Laspra, E, Echazarreta-Gallego, E, Elia-Guedea, M, Ramirez, J, Arredondo Chaves, J, Diez González, P, Elosua, T, Sahagún, J, Turienzo Frade, A, Álvarez Conde, J, Castrillo, E, Diaz Maag, R, Maderuelo, V, Saldarriaga, L, Aldrey Cao, I, Fernández Varela, X, Núñez Fernández, S, Parajó Calvo, A, Villar Álvarez, S, Blesa Sierra, I, Lozano, R, Márquez, M, Porcel, O, Menendez, P, Fernández Hevia, M, Flores Sigüenza, L, Jimenez Toscano, M, Lacy Fortuny, A, Ordoñez Trujillo, J, Espi, A, Garcia-Botello, S, Martín-Arévalo, J, Moro-Valdezate, D, Pla-Martí, V, Blanco-Antona, F, Abrisqueta, J, Ibañez Canovas, N, Lujan Mompean, J, Escolá Ripoll, D, Martinez Gonzalez, S, Parodi, J, Fernández López, A, Ramos Fernández, M, Castellvi Valls, J, Ortiz de Zarate, L, Ribas, R, Sabia, D, Viso, L, Alonso Gonçalves, S, José Gil Egea, M, Pascual Damieta, M, Pera, M, Salvans Ruiz, S, Bernal, J, Landete, F, Ais, G, Etreros, J, Aguiló Lucia, J, Boscá, A, Deusa, S, García Del Caño, J, Viciano, V, García-Armengol, J, Roig, J, Blas, J, Escartin, J, Fatás, J, Fernando, J, Ferrer, R, Arias Pacheco, R, García Flórez, L, Moreno Gijón, M, Otero Díez, J, Solar Garcia, L, Aguilar Teixido, F, Balaguer Ojo, C, Bargallo Berzosa, J, Lamas Moure, S, Enrique Sierra, J, Fermiñán, A, Herrerias, F, Rufas, M, Viñas, J, Codina-Cazador, A, Farrés, R, Gómez, N, Julià, D, Planellas, P, López, J, Luna, A, Maristany, C, Muñoz Duyos, A, Puértolas, N, Alcantara Moral, M, Serra-Aracil, X, Concheiro Coello, P, Gómez, D, Carton, C, Miguel, A, Reoyo Pascual, F, Valero Cerrato, X, Zambrano Muñoz, R, Cervera-Aldama, J, García González, J, Ramos-Prada, J, Santamaría-Olabarrieta, M, Urigüen-Echeverría, A, Coves Alcover, R, Espinosa Soria, J, Fernandez Rodriguez, E, Hernandis Villalba, J, Maturana Ibañez, V, De la Torre Gonzalez, F, Huerga, D, Pérez Viejo, E, Rivera, A, Ruiz Ucar, E, Garcia-Septiem, J, Jiménez, V, Jiménez Miramón, J, Ramons Rodriquez, J, Rodriguez Alvarez, V, Garcea, A, Ponchietti, L, Borda, N, Enriquez-Navascues, J, Saralegui, Y, Febles Molina, G, Nogues, E, Rodríguez Méndez, Á, Roque Castellano, C, Sosa Quesada, Y, Alvarez-Gallego, M, Pascual, I, Rubio-Perez, I, Diaz-San Andrés, B, Tone-Villanueva, F, Alonso, J, Cagigas, C, Castillo, J, Gómez, M, Martín-Parra, J, Mengual Ballester, M, Pellicer Franco, E, Soria Aledo, V, Valero Navarro, G, Caballero Rodríguez, E, Gonzalez De Chaves, P, Hernandez, G, Perez Alvarez, A, Soto Sanchez, A, Cesar Becerra Garcia, F, Guillermo Alonso Roque, J, López Rodríguez Arias, F, Del Valle Ruiz SR, Sánchez De La Villa, G, Compañ, A, García Marín, A, Nofuentes, C, Orts Micó, F, Pérez Auladell, V, Carrasco, M, Duque Perez, C, Gálvez-Pastor, S, Navarro Garcia, I, Sanchez Perez, A, Enjuto, D, Manuel Bujalance, F, Marcelin, N, Pérez, M, Serrano García, R, Cabrera, A, de la Portilla, F, Diaz-Pavon, J, Jimenez-Rodriguez, R, Vazquez-Monchul, J, Daza González, J, Gómez Pérez, R, Rivera Castellano, J, Roldán de la Rua, J, Errasti Alustiza, J, Fernandez, L, Romeo Ramirez, J, Sardon Ramos, J, Cermeño Toral, B, Alias, D, Garcia-Olmo, D, Guadalajara, H, Herreros, M, Pacheco, P, Del Castillo Díez, F, Lima Pinto, F, Martínez Alegre, J, Ortega, I, Picardo Nieto Antonio, A, Caro, A, Escuder, J, Feliu, F, Millan, M, Alos Company, R, Frangi Caregnato, A, Lozoya Trujillo, R, Rodríguez Carrillo, R, Ruiz Carmona, M, Alonso, N, Ambrona Zafra, D, Amilka Ayala Candia, B, Bonnin Pascual, J, Pineño Flores, C, Alcazar Montero, J, Angoso Clavijo, M, 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B., Diaz López, C., Navarro Rodriguez, E., Torres Tordera, E., Arenal, J., Citores, M., Marcos, J., Sánchez, J., Tinoco, C., Espin, E., Garcia Granero, A., Jimenez Gomez, L., Sanchez Garcia, J., Vallribera, F., Folkesson, J., Sköldberg, F., Bergman, K., Borgström, E., Frey, J., Silfverberg, A., Söderholm, M., Nygren, J., Segelman, J., Gustafsson, D., Lagerqvist, A., Papp, A., Pelczar, M., Abraham-Nordling, M., Ahlberg, M., Sjovall, A., Tengstrom, J., Hagman, K., Chabok, A., Ezra, E., Nikberg, M., Smedh, K., Tiselius, C., Al-Naimi, N., Dao Duc, M., Meyer, J., Mormont, M., Ris, F., Prevost, G., Villiger, P., Hoffmann, H., Kettelhack, C., Kirchhoff, P., Oertli, D., Weixler, B., Aytac, B., Leventoglu, S., Mentes, B., Yuksel, O., Demirbas, S., Busra Ozkan, B., Selçuk Özbalci, G., Sungurtekin, U., Gülcü, B., Ozturk, E., Yilmazlar, T., Challand, C., Fearnhead, N., Hubbard, R., Kumar, S., Arthur, J., Barben, C., Skaife, P., Slawik, S., Williams, M., Zammit, M., Barker, J., French, J., Sarantitis, I., Slawinski, C., Clifford, R., Eardley, N., Johnson, M., Mcfaul, C., Vimalachandran, D., Allan, S., Bell, A., Oates, E., Shanmugam, V., Brigic, A., Halls, M., Pucher, P., Stubbs, B., Agarwal, T., Chopada, A., Mallappa, S., Pathmarajah, M., Sugden, C., Brown, C., Macdonald, E., Mckay, A., Richards, J., Robertson, A., Kaushal, M., Patel, P., Tezas, S., Touqan, N., Ayaani, S., Marimuthu, K., Piramanayagam, B., Vourvachis, M., Iqbal, N., Korsgen, S., Seretis, C., Shariff, U., Arnold, S., Chan, H., Clark, E., Fernandes, R., Moran, B., Bajwa, A., Mcarthur, D., Cao, K., Cunha, P., Pardoe, H., Quddus, A., Theodoropoulou, K., Bolln, C., Denys, G., Gillespie, M., Manimaran, N., Reidy, J., Malik, A. I., Malik, A., Pitt, J., Aryal, K., El-Hadi, A., Lal, R., Pal, A., Velchuru, V., Oliveira Cunha, M., Thomas, M., Bains, S., Boyle, K., Miller, A., Norwood, M., Yeung, J., Goian, L., Gurjar, S., Saghir, W., Sengupta, N., Stewart-Parker, E., Bailey, S., Khalil, T., Lawes, D., Nikolaou, S., Omar, G., Church, R., Muthiah, B., Garrett, W., Marsh, P., Obeid, N., Chandler, S., Coyne, P., Evans, M., Hunt, L., Lim, J., Oliphant, Z., Papworth, E., Weaver, H., Cuiñas Leon, K., Williams, G., Hernon, J., Kapur, S., Moosvi, R., Shaikh, I., Swafe, L., Aslam, M., Evans, J., Ihedioha, U., Kang, P., Merchant, J., Hompes, R., Middleton, R., Broomfield, A., Crutten-Wood, D., Foster, J., Nash, G., Akhtar, M., Boshnaq, M., Eldesouky, S., Mangam, S., Rabie, M., Ahmed, J., Khan, J., Ming Goh, N., Shamali, A., Stefan, S., Thompson, C., Amin, A., Docherty, J., Lim, M., Walker, K., Watson, A., Hossack, M., Mackenzie, N., Paraoan, M., Alam, N., Daniels, I., Narang, S., Pathak, S., Smart, N., Al-Qaddo, A., Codd, R., Rutka, O., Bronder, C., Crighton, I., Davies, E., Raymond, T., Bookless, L., Griffiths, B., Plusa, S., Carlson, G., Harrison, R., Lees, N., Mason, C., Quayle, J., Branagan, G., Broadhurst, J., Chave, H., Sleight, S., Awad, F., Cruickshank, N., Joy, H., Boereboom, C., Daliya, P., Dhillon, A., Watson, N., Watson, R., Artioukh, D., Gokul, K., Javed, M., Kong, R., Sutton, J., Faiz, O., Jenkins, I., Leo, C. A., Samaranayake, S. F., Warusavitarne, J., Arya, S., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Duff, S., Fatayer, T., Mbuvi, J., Sharma, A., Cornish, J., Davies, L., Harries, R., Morris, C., Torkington, J., Knight, J., Lai, C., Shihab, O., Tzivanakis, A., Hussain, A., Luke, D., Padwick, R., Torrance, A., Tsiamis, A., Dawson, P., Balfour, A., Brady, R., Mander, J., Paterson, H., Chandratreya, N., Chu, H., Cutting, J., Vernon, S., Wai Ho, C., Andreani, S., Patel, H., Warner, M., Yan Qi Tan, J., Iqbal, A., Khan, A., Perrin, K., Raza, A., Tan, S., Meyer, Jérémy, Graduate School, TOBB ETÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, TOBB ETU, Faculty of Medicine, Department of Surgical Sciences, and Demirbaş, Sezai

Subjects
Crohn’s disease, Male, Leak, Surgi-cal technique, anastomotic leak, Bowel anastomosis, colorectal cancer, Crohn's disease, epidemiology, international, oversewn, stapler, surgery, surgical technique, Colorectal cancer, medicine.medical_treatment, 030230 surgery, Colon/surgery, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Epidemiology, Prospective Studies, Treatment Failure, Young adult, Prospective cohort study, Colectomy, Aged, 80 and over, General Surgery/statistics & numerical data, Medical Audit, ddc:617, Anastomosis, Surgical, Gastroenterology, Middle Aged, Colorectal Neoplasms/surgery, Colorectal surgery, 030220 oncology & carcinogenesis, Female, Colectomy/adverse effects, Colorectal Neoplasms, Anastomotic Leak/etiology, Adult, medicine.medical_specialty, Adolescent, Colon, bowel anastomosis, Colorectal Surgery/statistics & numerical data, Anastomosis, NO, Young Adult, 03 medical and health sciences, Surgical Stapling, medicine, Humans, Aged, ta3126, business.industry, Anastomosis, Surgical/adverse effects, Surgical Stapling/adverse effects, Bowel anastomosi, medicine.disease, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], General Surgery, business, Colorectal Surgery
Abstract

AIM: There is little evidence to support choice of technique and configuration for stapled anastomoses after right hemicolectomy and ileocaecal resection. This study aimed to determine the relationship between stapling technique and anastomotic failure.METHOD: Any unit performing gastrointestinal surgery was invited to contribute data on consecutive adult patients undergoing right hemicolectomy or ileocolic resection to this prospective, observational, international, multicentre study. Patients undergoing stapled, side-to-side ileocolic anastomoses were identified and multilevel, multivariable logistic regression analyses were performed to explore factors associated with anastomotic leak.RESULTS: One thousand three hundred and forty-seven patients were included from 200 centres in 32 countries. The overall anastomotic leak rate was 8.3%. Upon multivariate analysis there was no difference in leak rate with use of a cutting stapler for apical closure compared with a noncutting stapler (8.4% vs 8.0%, OR 0.91, 95% CI 0.54-1.53, P = 0.72). Oversewing of the apical staple line, whether in the cutting group (7.9% vs 9.7%, OR 0.87, 95% CI 0.52-1.46, P = 0.60) or noncutting group (8.9% vs 5.7%, OR 1.40, 95% CI 0.46-4.23, P = 0.55) also conferred no benefit in terms of reducing leak rates. Surgeons reporting to be general surgeons had a significantly higher leak rate than those reporting to be colorectal surgeons (12.1% vs 7.3%, OR 1.65, 95% CI 1.04-2.64, P = 0.04).CONCLUSION: This study did not identify any difference in anastomotic leak rates according to the type of stapling device used to close the apical aspect. In addition, oversewing of the anastomotic staple lines appears to confer no benefit in terms of reducing leak rates. Although general surgeons operated on patients with more high-risk characteristics than colorectal surgeons, a higher leak rate for general surgeons which remained after risk adjustment needs further exploration.

Published
2018

16. Randomized multicentre feasibility trial of intermediate care versus standard ward care after emergency abdominal surgery (InCare trial)

Author

Vester-Andersen, M., Waldau, T., Wetterslev, J., Mller, M. H., Rosenberg, J., Jrgensen, L. N., Jakobsen, J. C., Mller, A. M., Gillesberg, I. E., Jakobsen, H. L., Hansen, E. G., Poulsen, L. M., Skovdal, J., Sgaard, E. K., Bestle, M., Vilandt, J., Rosenberg, I., Itenov, T. S., Pedersen, J., Madsen, M. R., Maschmann, C., Rasmussen, M., Jessen, C., and Bugge, L.

Published
2015
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19. Pelagic habitats under MSFD D1: scientific advice of policy relevance Recommendations to frame problems and solutions for the pelagic habitats' assessment

Author

Magliozzi, C., Druon, J. N., Palialexis, A., Aguzzi, L., Alexande, B., Antoniadis, K., Artigas, L. F., Azzellino, A., Bisinicu, E., Boicenco, L., Bojanic, N., Francé, Janja, Boschetti, S., Carmo, V., Cervantes, P., Coll, M., Curmi, M., Del Amo, Y., Dutz, J., Garcés, E., Gea, G, Giannakourou, A, Goberville, E, Goffart, A, Gomes Pereira, J. N., González-Quirós, R., Gorokhova, E., Helaouet, P., Henriques, F., Heyden, B, Jakobsen, H., Johansen, M., Jurgensone, I., Korpinen, S., Kremp, A., Kuosa, H., Labayle, L., Lazar, L., Guglielmo, L., McQuatters-Gollop, A., Živana Ninčević Gladan, Pagou, Kalliopi, Penna, Antonella, Pettersson, K., Ruiter, H., Skejic, Sanda, Spada, E., Spinu, A., Tew-Kai, E., Totti, C., Tunesi, L., Vadrucci, M. R., Valavanis, V., Varkitzi, Ioanna, Vasiliades, L., Veldeki, G., Vidjak, Olja, Vincent, D., and Zervoudaki, S.

Published
2021
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25. Patients with Crohn's disease have longer post-operative in-hospital stay than patients with colon cancer but no difference in complications' rate

Author

Dich Grandt, S, El-Hussuna, A, Frasson, M, Singh, B, Gallo, G, Pata, F, Negoi, I, Pinkney, T, Zmora, O, Bhangu, A, Battersby, N, Chaudhri, S, Nepogodiev, D, Vennix, S, Glasbey, J, Minaya, A, Basso, L, Pukuotukai, M, Kelly, Me, Sánchez Guillén, L, Pellino, G, Buchs, N, Morton, D, Bemelman, W, Christensen, P, D'Hoore, A, Laurberg, S, Rubbini, M, Vaizey, C, Magill, L, Perry, R, Sheward, N, Mortensen, Rn, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Salomon, M, Makhmudov, A, Selnyahina, L, Varabei, A, Vizhynis, Y, Claeys, D, Defoort, B, Muysoms, F, Pletinckx, P, Vergucht, V, Debergh, I, Feryn, T, Reusens, H, Francart, D, Jehaes, C, Markiewicz, S, Monami, B, Weerts, J, Bouckaert, W, Houben, B, Knol, J, Sergeant, G, Vangertruyden, G, Haeck, L, Lange, C, Sommeling, C, Vindevoghel, K, Castro, S, De Bruyn, H, Huyghe, M, De Wolf, E, Reynders, D, de Buck van Overstraeten, A, Wolthuis, A, Delibegovic, S, Christiani, A, Marchiori, M Jr, Rocha de Moraes, C, Tercioti, V Jr, Arabadjieva, E, Bulanov, D, Dardanov, D, Stoyanov, V, Yonkov, A, Angelov, K, Maslyankov, S, Sokolov, M, Todorov, G, Toshev, S, Georgiev, Y, Karashmalakov, A, Zafirov, G, Wang, X, Condic, D, Kraljik, D, Mrkovic, H, Pavkovic, V, Raguž, K, Bencurik, V, Holášková, E, Skrovina, M, Farkašová, M, Grolich, T, Kala, Z, Antos, F, Pruchova, V, Sotona, O, Chobola, M, Dusek, T, Ferko, A, Örhalmi, J, Hoch, J, Kocian, P, Martinek, L, Bernstein, I, Gotschalck Sunesen, K, Leunbach, J, Thorlacius-Ussing, O, Uth Oveson, A, Dahl Chirstensen, S, Gamez, V, Oeting, M, Schou Loeve, U, Ugianskis, A, Jessen, M, Krarup, Pm, Linde, K, Mirza, Q, Overgaard Stovring, J, Erritzøe, L, Loft Jakobsen, H, Lykke, J, Palmgren Colov, E, Husted Madsen, A, Linde Friis, T, Amstrup Funder, J, Dich, R, Kjær, S, Rasmussen, S, Schlesinger, N, Dilling Kjaer, M, Qvist, N, Khalid, A, Ali, G, Hadi, S, Rosell Walker, L, Kivelä, A, Lehtonen, T, Lepistö, A, Scheinin, T, Siironen, P, Kössi, J, Kuusanmäki, P, Tomminen, T, Turunen, A, Rautio, T, Vierimaa, 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Trujillo, R, Rodríguez Carrillo, R, Ruiz Carmona, M, Alonso, N, Ambrona Zafra, D, Amilka Ayala, B, Bonnin Pascual, Cj, Pineño Flores, C, Alcazar Montero, J, Angoso Clavijo, M, Garcia, J, Sanchez Tocino, J, Gómez Alcazar, C, Costa Navarro, D, Ferri Romero, J, Rey Riveiro, M, Romero Simó, M, Arencibia, B, Esclapez, P, García Granero, E, Granero, P, Medina Fernández, Fj, Gallardo Herrera, Ab, Diaz López, C, Navarro Rodriguez, E, Torres Tordera, E, Arenal, J, Citores, M, Marcos, J, Sánchez, J, Tinoco, C, Espin, E, Garcia Granero, A, Jimenez Gomez, L, Sanchez Garcia, J, Vallribera, F, Folkesson, J, Sköldberg, F, Bergman, K, Borgström, E, Frey, J, Silfverberg, A, Söderholm, M, Nygren, J, Segelman, J, Gustafsson, D, Lagerqvist, A, Papp, A, Pelczar, M, Abraham Nordling, M, Ahlberg, M, Sjovall, A, Tengstrom, J, Hagman, K, Chabok, A, Ezra, E, Nikberg, M, Smedh, K, Tiselius, C, Al Naimi, N, Dao Duc, M, Meyer, J, Mormont, M, Ris, F, Prevost, G, Villiger, P, Hoffmann, H, Kettelhack, C, Kirchhoff, P, Oertli, D, Weixler, B, Aytac, B, Leventoglu, S, Mentes, B, Yuksel, O, Demirbas, S, Busra Ozkan, B, Selçuk Özbalci, G, Sungurtekin, U, Gülcü, B, Ozturk, E, Yilmazlar, T, Challand, C, Fearnhead, N, Hubbard, R, Kumar, S, Arthur, J, Barben, C, Skaife, P, Slawik, S, Williams, M, Zammit, M, Barker, J, French, J, Sarantitis, I, Slawinski, C, Clifford, R, Eardley, N, Johnson, M, Mcfaul, C, Vimalachandran, D, Allan, S, Bell, A, Oates, E, Shanmugam, V, Brigic, A, Halls, M, Pucher, P, Stubbs, B, Agarwal, T, Chopada, A, Mallappa, S, Pathmarajah, M, Sugden, C, Brown, C, Macdonald, E, Mckay, A, Richards, J, Robertson, A, Kaushal, M, Patel, P, Tezas, S, Touqan, N, Ayaani, S, Marimuthu, K, Piramanayagam, B, Vourvachis, M, Iqbal, N, Korsgen, S, Seretis, C, Shariff, U, Arnold, S, Chan, H, Clark, E, Fernandes, R, Moran, B, Bajwa, A, Mcarthur, D, Cao, K, Cunha, P, Pardoe, H, Quddus, A, Theodoropoulou, K, Bolln, C, Denys, G, Gillespie, M, Manimaran, N, Reidy, J, Malik, Ai, Malik, A, Pitt, J, Aryal, K, El Hadi, A, Lal, R, Pal, A, Velchuru, V, Oliveira Cunha, M, Thomas, M, Bains, S, Boyle, K, Miller, A, Norwood, M, Yeung, J, Goian, L, Gurjar, S, Saghir, W, Sengupta, N, Stewart Parker, E, Bailey, S, Khalil, T, Lawes, D, Nikolaou, S, Omar, G, Church, R, Muthiah, B, Garrett, W, Marsh, P, Obeid, N, Chandler, S, Coyne, P, Evans, M, Hunt, L, Lim, J, Oliphant, Z, Papworth, E, Weaver, H, Cuiñas Leon, K, Williams, G, Hernon, J, Kapur, S, Moosvi, R, Shaikh, I, Swafe, L, Aslam, M, Evans, J, Ihedioha, U, Kang, P, Merchant, J, Hompes, R, Middleton, R, Broomfield, A, Crutten Wood, D, Foster, J, Nash, G, Akhtar, M, Boshnaq, M, Eldesouky, S, Mangam, S, Rabie, M, Ahmed, J, Khan, J, Ming Goh, N, Shamali, A, Stefan, S, Thompson, C, Amin, A, Docherty, J, Lim, M, Walker, K, Watson, A, Hossack, M, Mackenzie, N, Paraoan, M, Alam, N, Daniels, I, Narang, S, Pathak, S, Smart, N, Al Qaddo, A, Codd, R, Rutka, O, Bronder, C, Crighton, I, Davies, E, Raymond, T, Bookless, L, Griffiths, B, Plusa, S, Carlson, G, Harrison, R, Lees, N, Mason, C, Quayle, J, Branagan, G, Broadhurst, J, Chave, H, Sleight, S, Awad, F, Cruickshank, N, Joy, H, Boereboom, C, Daliya, P, Dhillon, A, Watson, N, Watson, R, Artioukh, D, Gokul, K, Javed, M, Kong, R, Sutton, J, Faiz, O, Jenkins, I, Leo, Ca, Samaranayake, Sf, Warusavitarne, J, Arya, S, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Duff, S, Fatayer, T, Mbuvi, J, Sharma, A, Cornish, J, Davies, L, Harries, R, Morris, C, Torkington, J, Knight, J, Lai, C, Shihab, O, Tzivanakis, A, Hussain, A, Luke, D, Padwick, R, Torrance, A, Tsiamis, A, Dawson, P, Balfour, A, Brady, R, Mander, J, Paterson, H, Chandratreya, N, Chu, H, Cutting, J, Vernon, S, Wai Ho, C, Andreani, S, Patel, H, Warner, M, Tan, Yq, Iqbal, A, Khan, A, Perrin, K, Raza, A, and S Tan, And

Subjects
Crohn’s disease, medicine.medical_specialty, Complications, Colorectal cancer, SURGERY, medicine.medical_treatment, Bowel resection, Disease, Inflammatory bowel disease, NO, COLORECTAL-CANCER, 03 medical and health sciences, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], MORBIDITY, 0302 clinical medicine, Medicine, Crohn’s disease, Colon cancer, Complications, Length of stay, Bowel resection, Right hemicolectomy, DIVERTICULAR-DISEASE, Colon cancer, Length of stay, Right hemicolectomy, colon cancer, complications, length of stay, bowel resection, right hemicolectomy, PREOPERATIVE OPTIMIZATION, RISK, Crohn's disease, ddc:617, business.industry, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, digestive system diseases, Surgery, 030220 oncology & carcinogenesis, 3121 General medicine, internal medicine and other clinical medicine, Diverticular disease, Prospective Study, 030211 gastroenterology & hepatology, SMOKING, business, Complication, Hospital stay, INFLAMMATORY-BOWEL-DISEASE
Abstract

BACKGROUND: Right hemicolectomy or ileocecal resection are used to treat benign conditions like Crohn's disease (CD) and malignant ones like colon cancer (CC).AIM: To investigate differences in pre- and peri-operative factors and their impact on post-operative outcome in patients with CC and CD.METHODS: This is a sub-group analysis of the European Society of Coloproctology's prospective, multi-centre snapshot audit. Adult patients with CC and CD undergoing right hemicolectomy or ileocecal resection were included. Primary outcome measure was 30-d post-operative complications. Secondary outcome measures were post-operative length of stay (LOS) at and readmission.RESULTS: Three hundred and seventy-five patients with CD and 2,515 patients with CC were included. Patients with CD were younger (median = 37 years for CD and 71 years for CC (P < 0.01), had lower American Society of Anesthesiology score (ASA) grade (P < 0.01) and less comorbidity (P < 0.01), but were more likely to be current smokers (P < 0.01). Patients with CD were more frequently operated on by colorectal surgeons (P < 0.01) and frequently underwent ileocecal resection (P < 0.01) with higher rate of de-functioning/primary stoma construction (P < 0.01). Thirty-day post-operative mortality occurred exclusively in the CC group (66/2515, 2.3%). In multivariate analyses, the risk of post-operative complications was similar in the two groups (OR 0.80, 95%CI: 0.54-1.17; P = 0.25). Patients with CD had a significantly longer LOS (Geometric mean 0.87, 95%CI: 0.79-0.95; P < 0.01). There was no difference in re-admission rates. The audit did not collect data on post-operative enhanced recovery protocols that are implemented in the different participating centers.CONCLUSION: Patients with CD were younger, with lower ASA grade, less comorbidity, operated on by experienced surgeons and underwent less radical resection but had a longer LOS than patients with CC although complications' rate was not different between the two groups.

Published
2019

28. Dimorphism in cryptophytes - The case of Teleaulax amphioxeia/Plagioselmis prolonga and its ecological implications

Author

Altenburger, A., Blossom, H. E., Garcia-Cuetos, L., Jakobsen, H. H., Carstensen, J., Lundholm, N., Hansen, P. J., Moestrup, Ø., Haraguchi, L., Altenburger, A., Blossom, H. E., Garcia-Cuetos, L., Jakobsen, H. H., Carstensen, J., Lundholm, N., Hansen, P. J., Moestrup, Ø., and Haraguchi, L.

Abstract

Growing evidence suggests that sexual reproduction might be common in unicellular organisms, but observations are sparse. Limited knowledge of sexual reproduction constrains understanding of protist ecology. Although Teleaulax amphioxeia and Plagioselmis prolonga are common marine cryptophytes worldwide, and are also important plastid donors for some kleptoplastic ciliates and dinoflagellates, the ecology and development of these protists are poorly known. We demonstrate that P. prolonga is the haploid form of the diploid T. amphioxeia and describe the seasonal dynamics of these two life stages. The diploid T. amphioxeia dominates during periods of high dissolved inorganic nitrogen (DIN) and low irradiance, temperature, and grazing (winter and early spring), whereas the haploid P. prolonga becomes more abundant during the summer, when DIN is low and irradiance, temperature, and grazing are high. Dimorphic sexual life cycles might explain the success of this species by fostering high genetic diversity and enabling endurance in adverse conditions.

Published
2020

34. Risk factors for unfavourable postoperative outcome in patients with Crohn's disease undergoing right hemicolectomy or ileocaecal resection. An international audit by ESCP and S-ECCO

Author

El-Hussuna, A., Pinkney, T., Zmora, O., Frasson, M., Bhangu, A., Battersby, N., Chaudhri, S., Nepogodiev, D., Singh, B., Vennix, S., Altomare, D., Bemelman, W., Christensen, P., D'Hoore, A., Laurberg, S., Morton, D., Rubbini, M., Vaizey, C., Magill, L., Perry, R., Sheward, N., Nørmark Mortensen, Rikke, El-Hussuna, Alaa, Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Salomon, M., Makhmudov, A., Selnyahina, L., Varabei, A., Vizhynis, Y., Claeys, D., Defoort, B., Muysoms, F., Pletinckx, P., Vergucht, V., Debergh, I., Feryn, T., Reusens, H., Nachtergaele, M., Francart, D., Jehaes, C., Markiewicz, S., Monami, B., Weerts, J., Bouckaert, W., Houben, B., Knol, J., Sergeant, G., Vangertruyden, G., Haeck, L., Lange, C., Sommeling, C., Vindevoghel, K., Castro, S., De Bruyn, H., Huyghe, M., De Wolf, E., Reynders, D., de Buck van Overstraeten, A., Wolthuis, A., Delibegovic, S., Christiani, A., Marchiori, M., Rocha de Moraes, C., Tercioti, V., Arabadjieva, E., Bulanov, D., Dardanov, D., Stoyanov, V., Yonkov, A., Angelov, K., Maslyankov, S., Sokolov, M., Todorov, G., Toshev, S., Georgiev, Y., Karashmalakov, A., Zafirov, G., Wang, X., Condic, D., Kraljik, D., Mrkovic, H., Pavkovic, V., Raguž, K., Bencurik, V., Holášková, E., Skrovina, M., Farkašová, M., Grolich, T., Kala, Z., Antos, F., Pruchova, V., Sotona, O., Chobola, M., Dusek, T., Ferko, A., Örhalmi, J., Hoch, J., Kocian, P., Martinek, L., Bernstein, I., Gotschalck Sunesen, K., Leunbach, J., Thorlacius-Ussing, O., Uth Oveson, A., Dahl Chirstensen, S., Gamez, V., Oeting, M., Schou Loeve, U., Ugianskis, A., Jessen, M., Krarup, P. M., Linde, K., Mirza, Q., Overgaard Stovring, J., Erritzøe, L., Loft Jakobsen, H., Lykke, J., Palmgren Colov, E., Husted Madsen, A., Linde Friis, T., Amstrup Funder, J., Dich, R., Kjær, S., Rasmussen, S., Schlesinger, N., Dilling Kjaer, M., Qvist, N., Khalid, A., Ali, G., Hadi, S., Rosell Walker, L., Kivelä, A., Lehtonen, T., Lepistö, A., Scheinin, T., Siironen, P., Kössi, J., Kuusanmäki, P., Tomminen, T., Turunen, A., Rautio, T., Vierimaa, M., Huhtinen, H., Karvonen, J., Lavonius, M., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Kepenekian, V., Passot, G., Maggiori, L., Manceau, G., Panis, Y., Gout, M., Rullier, E., van Geluwe, B., Chafai, N., Lefevre, J. H., Parc, Y., Tiret, E., Couette, C., Duchalais, E., Agha, A., Hornberger, M., Hungbauer, A., Iesalnieks, I., Weindl, I., Crescenti, F., Keller, M., Kolodziejski, N., Scherer, R., Sterzing, D., Bock, B., Boehm, G., El-Magd, M., Krones, C., Niewiera, M., Buhr, J., Cordesmeyer, S., Hoffmann, M., Krückemeier, K., Vogel, T., Schön, M., Baral, J., Lukoschek, T., Münch, S., Pullig, F., Horisberger, K., Kienle, P., Magdeburg, J., Post, S., Batzalexis, K., Germanos, S., Agalianos, C., Dervenis, C., Gouvas, N., Kanavidis, P., Kottikias, A., Katsoulis, I. E., Korkolis, D., Plataniotis, G., Sakorafas, G., Akrida, I., Argentou, M., Kollatos, C., Lampropoulos, C., Tsochatzis, S., Besznyák, I., Bursics, A., Egyed, T., Papp, G., Svastics, I., Atladottir, J., Möller, P., Sigurdsson, H., Stefánsson, T., Valsdottir, E., Andrews, E., Foley, N., Hechtl, D., Majeed, M., Mccourt, M., Hanly, A., Hyland, J., Martin, S., O'Connell, P. R., Winter, D., Connelly, T., Joyce, W., Wrafter, P., Berkovitz, R., Avital, S., Haj Yahia, I., Hermann, N., Shpitz, B., White, I., Lishtzinsky, Y., Tsherniak, A., Wasserberg, N., Horesh, N., Keler, U., Pery, R., Shapiro, R., Tulchinsky, H., Badran, B., Dayan, K., Iskhakov, A., Lecaros, J., Nabih, N., Angriman, I., Bardini, R., Pizzolato, E., Tonello, M., Arces, F., Balestri, R., Ceccarelli, C., Prosperi, V., Rossi, E., Giannini, I., Vincenti, L., Altomare, D. F., Di Candido, F., Di Iena, M., Guglielmi, A., Caputi-Iambrenghi, O., Marsanic, P., Mellano, A., Muratore, A., Annecchiarico, M., Bencini, L., Amore Bonapasta, S., Coratti, A., Guerra, F., Asteria, C. R., Boccia, L., Gerard, L., Pascariello, A., Manca, G., Marino, F., Casaril, A., Inama, M., Moretto, G., Bacchelli, C., Carvello, M., Mariani, N., Montorsi, M., Spinelli, A., Romairone, E., Scabini, S., Belli, A., Bianco, F., De Franciscis, S., Maria Romano, G., Delrio, P., Pace, U., Rega, D., Sassaroli, C., Scala, D., De Luca, R., Ruggieri, E., Elbetti, C., Garzi, A., Romoli, L., Scatizzi, M., Vannucchi, A., Curletti, G., Durante, V., Galleano, R., Mariani, F., Reggiani, L., Bellomo, R., Infantino, A., Franceschilli, L., Sileri, P., Clementi, I., Coletta, D., La Torre, F., Mingoli, A., Velluti, F., Di Giacomo, A., Fiorot, A., Massani, M., Padoan, L., Ruffolo, C., Caruso, S., Franceschini, F., Laessig, R., Monaci, I., Rontini, M., De Nardi, P., Elmore, U., Lemma, M., Rosati, R., Tamburini, A., De Luca, M., Sartori, A., Benevento, A., Bottini, C., Ferrari, C. C., Pata, F., Tessera, G., Pellino, G., Selvaggi, F., Lanzani, A., Romano, F., Sgroi, G., Steccanella, F., Turati, L., Yamamoto, T., Ancans, G., Gerkis, S., Leja, M., Pcolkins, A., Sivins, A., Latkauskas, T., Lizdenis, P., Saladžinskas, Ž., Švagždys, S., Tamelis, A., Razbadauskas, A., Sokolovas, M., Dulskas, A., Samalavicius, N., Jotautas, V., Mikalauskas, S., Poskus, E., Poskus, T., Strupas, K., Camenzuli, C., Cini, C., Predrag, A., Psaila, J., Spiteri, N., Buskens, C., de Groof, E. J., Gooszen, J., Tanis, P., Belgers, E., Davids, P., Furnee, E., Postma, E., Pronk, A., Smakman, N., Clermonts, S., Zimmerman, D., Omloo, J., van der Zaag, E., van Duijvendijk, P., Wassenaar, E., Bruijninckx, M., de Graff, E., Doornebosch, P., Tetteroo, G., Vermaas, M., Iordens, G., Knops, S., Toorenvliet, B., van Westereenen, H. 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Cumplido, P, Padin, H, Baixauli Fons, J, Hernández-Lizoain, J, Martinez-Ortega, P, Molina-Fernández, M, Sánchez-Justicia, C, Antonio Gracia Solanas, J, Córdoba Díaz de Laspra, E, Echazarreta-Gallego, E, Elia-Guedea, M, Ramirez, J, Arredondo Chaves, J, Diez González, P, Elosua, T, Sahagún, J, Turienzo Frade, A, Álvarez Conde, J, Castrillo, E, Diaz Maag, R, Maderuelo, V, Saldarriaga, L, Aldrey Cao, I, Fernández Varela, X, Núñez Fernández, S, Parajó Calvo, A, Villar Álvarez, S, Blesa Sierra, I, Lozano, R, Márquez, M, Porcel, O, Menendez, P, Fernández Hevia, M, Flores Sigüenza, L, Jimenez Toscano, M, Lacy Fortuny, A, Ordoñez Trujillo, J, Espi, A, Garcia-Botello, S, Martín-Arévalo, J, Moro-Valdezate, D, Pla-Martí, V, Blanco-Antona, F, Abrisqueta, J, Ibañez Canovas, N, Lujan Mompean, J, Escolá Ripoll, D, Martinez Gonzalez, S, Parodi, J, Fernández López, A, Ramos Fernández, M, Castellvi Valls, J, Ortiz de Zarate, L, Ribas, R, Sabia, D, Viso, L, Alonso Gonçalves, S, José Gil Egea, M, Pascual Damieta, M, Pera, M, Salvans Ruiz, S, Bernal, J, Landete, F, Ais, G, Etreros, J, Aguiló Lucia, J, Boscá, A, Deusa, S, García Del Caño, J, Viciano, V, García-Armengol, J, Roig, J, Blas, J, Escartin, J, Fatás, J, Fernando, J, Ferrer, R, Arias Pacheco, R, García Flórez, L, Moreno Gijón, M, Otero Díez, J, Solar Garcia, L, Aguilar Teixido, F, Balaguer Ojo, C, Bargallo Berzosa, J, Lamas Moure, S, Enrique Sierra, J, Fermiñán, A, Herrerias, F, Rufas, M, Viñas, J, Codina-Cazador, A, Farrés, R, Gómez, N, Julià, D, Planellas, P, López, J, Luna, A, Maristany, C, Muñoz Duyos, A, Puértolas, N, Alcantara Moral, M, Serra-Aracil, X, Concheiro Coello, P, Gómez, D, Carton, C, Miguel, A, Reoyo Pascual, F, Valero Cerrato, X, Zambrano Muñoz, R, Cervera-Aldama, J, García González, J, Ramos-Prada, J, Santamaría-Olabarrieta, M, Urigüen-Echeverría, A, Coves Alcover, R, Espinosa Soria, J, Fernandez Rodriguez, E, Hernandis Villalba, J, Maturana Ibañez, V, De la Torre Gonzalez, F, Huerga, D, Pérez Viejo, E, Rivera, A, Ruiz Ucar, E, Garcia-Septiem, J, Jiménez, V, Jiménez Miramón, J, Ramons Rodriquez, J, Rodriguez Alvarez, V, Garcea, A, Ponchietti, L, Borda, N, Enriquez-Navascues, J, Saralegui, Y, Febles Molina, G, Nogues, E, Rodríguez Méndez, Á, Roque Castellano, C, Sosa Quesada, Y, Alvarez-Gallego, M, Pascual, I, Rubio-Perez, I, Diaz-San Andrés, B, Tone-Villanueva, F, Alonso, J, Cagigas, C, Castillo, J, Gómez, M, Martín-Parra, J, Mengual Ballester, M, Pellicer Franco, E, Soria Aledo, V, Valero Navarro, G, Caballero Rodríguez, E, Gonzalez De Chaves, P, Hernandez, G, Perez Alvarez, A, Soto Sanchez, A, Cesar Becerra Garcia, F, Guillermo Alonso Roque, J, López Rodríguez Arias, F, Del Valle Ruiz, Sr, Sánchez De La Villa, G, Compañ, A, García Marín, A, Nofuentes, C, Orts Micó, F, Pérez Auladell, V, Carrasco, M, Duque Perez, C, Gálvez-Pastor, S, Navarro Garcia, I, Sanchez Perez, A, Enjuto, D, Manuel Bujalance, F, Marcelin, N, Pérez, M, Serrano García, R, Cabrera, A, de la Portilla, F, Diaz-Pavon, J, Jimenez-Rodriguez, R, Vazquez-Monchul, J, Daza González, J, Gómez Pérez, R, Rivera Castellano, J, Roldán de la Rua, J, Errasti Alustiza, J, Fernandez, L, Romeo Ramirez, J, Sardon Ramos, J, Cermeño Toral, B, Alias, D, Garcia-Olmo, D, Guadalajara, H, Herreros, M, Pacheco, P, Del Castillo Díez, F, Lima Pinto, F, Martínez Alegre, J, Ortega, I, Picardo Nieto Antonio, A, Caro, A, Escuder, J, Feliu, F, Millan, M, Alos Company, R, Frangi Caregnato, A, Lozoya Trujillo, R, Rodríguez Carrillo, R, Ruiz Carmona, M, Alonso, N, Ambrona Zafra, D, Amilka Ayala Candia, B, Bonnin Pascual, J, Pineño Flores, C, Alcazar Montero, J, Angoso Clavijo, M, Garcia, J, Sanchez Tocino, J, Gómez-Alcazar, C, Costa-Navarro, D, Ferri-Romero, J, Rey-Riveiro, M, Romero-Simó, M, Arencibia, B, Esclapez, P, García-Granero, E, Granero, P, Medina Fernández, Fj, Gallardo Herrera, Ab, Diaz López, C, Navarro Rodriguez, E, Torres Tordera, E, Arenal, J, Citores, M, Marcos, J, Sánchez, J, Tinoco, C, Espin, E, Garcia Granero, A, Jimenez Gomez, L, Sanchez Garcia, J, Vallribera, F, Folkesson, J, Sköldberg, F, Bergman, K, Borgström, E, Frey, J, Silfverberg, A, Söderholm, M, Nygren, J, Segelman, J, Gustafsson, D, Lagerqvist, A, Papp, A, Pelczar, M, Abraham-Nordling, M, Ahlberg, M, Sjovall, A, Tengstrom, J, Hagman, K, Chabok, A, Ezra, E, Nikberg, M, Smedh, K, Tiselius, C, Al-Naimi, N, Dao Duc, M, Meyer, J, Mormont, M, Ris, F, Prevost, G, Villiger, P, Hoffmann, H, Kettelhack, C, Kirchhoff, P, Oertli, D, Weixler, B, Aytac, B, Leventoglu, S, Mentes, B, Yuksel, O, Demirbas, S, Busra Ozkan, B, Selçuk Özbalci, G, Sungurtekin, U, Gülcü, B, Ozturk, E, Yilmazlar, T, Challand, C, Fearnhead, N, Hubbard, R, Kumar, S, Arthur, J, Barben, C, Skaife, P, Slawik, S, Williams, M, Zammit, M, Barker, J, French, J, Sarantitis, I, Slawinski, C, Clifford, R, Eardley, N, Johnson, M, Mcfaul, C, Vimalachandran, D, Allan, S, Bell, A, Oates, E, Shanmugam, V, Brigic, A, Halls, M, Pucher, P, Stubbs, B, Agarwal, T, Chopada, A, Mallappa, S, Pathmarajah, M, Sugden, C, Brown, C, Macdonald, E, Mckay, A, Richards, J, Robertson, A, Kaushal, M, Patel, P, Tezas, S, Touqan, N, Ayaani, S, Marimuthu, K, Piramanayagam, B, Vourvachis, M, Iqbal, N, Korsgen, S, Seretis, C, Shariff, U, Arnold, S, Chan, H, Clark, E, Fernandes, R, Moran, B, Bajwa, A, Mcarthur, D, Cao, K, Cunha, P, Pardoe, H, Quddus, A, Theodoropoulou, K, Bolln, C, Denys, G, Gillespie, M, Manimaran, N, Reidy, J, Malik, Ai, Malik, A, Pitt, J, Aryal, K, El-Hadi, A, Lal, R, Pal, A, Velchuru, V, Oliveira Cunha, M, Thomas, M, Bains, S, Boyle, K, Miller, A, Norwood, M, Yeung, J, Goian, L, Gurjar, S, Saghir, W, Sengupta, N, Stewart-Parker, E, Bailey, S, Khalil, T, Lawes, D, Nikolaou, S, Omar, G, Church, R, Muthiah, B, Garrett, W, Marsh, P, Obeid, N, Chandler, S, Coyne, P, Evans, M, Hunt, L, Lim, J, Oliphant, Z, Papworth, E, Weaver, H, Cuiñas Leon, K, Williams, G, Hernon, J, Kapur, S, Moosvi, R, Shaikh, I, Swafe, L, Aslam, M, Evans, J, Ihedioha, U, Kang, P, Merchant, J, Hompes, R, Middleton, R, Broomfield, A, Crutten-Wood, D, Foster, J, Nash, G, Akhtar, M, Boshnaq, M, Eldesouky, S, Mangam, S, Rabie, M, Ahmed, J, Khan, J, Ming Goh, N, Shamali, A, Stefan, S, Thompson, C, Amin, A, Docherty, J, Lim, M, Walker, K, Watson, A, Hossack, M, Mackenzie, N, Paraoan, M, Alam, N, Daniels, I, Narang, S, Pathak, S, Smart, N, Al-Qaddo, A, Codd, R, Rutka, O, Bronder, C, Crighton, I, Davies, E, Raymond, T, Bookless, L, Griffiths, B, Plusa, S, Carlson, G, Harrison, R, Lees, N, Mason, C, Quayle, J, Branagan, G, Broadhurst, J, Chave, H, Sleight, S, Awad, F, Cruickshank, N, Joy, H, Boereboom, C, Daliya, P, Dhillon, A, Watson, N, Watson, R, Artioukh, D, Gokul, K, Javed, M, Kong, R, Sutton, J, Faiz, O, Jenkins, I, Leo, Ca, Samaranayake, Sf, Warusavitarne, J, Arya, S, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Duff, S, Fatayer, T, Mbuvi, J, Sharma, A, Cornish, J, Davies, L, Harries, R, Morris, C, Torkington, J, Knight, J, Lai, C, Shihab, O, Tzivanakis, A, Hussain, A, Luke, D, Padwick, R, Torrance, A, Tsiamis, A, Dawson, P, Balfour, A, Brady, R, Mander, J, Paterson, H, Chandratreya, N, Chu, H, Cutting, J, Vernon, S, Wai Ho, C, Andreani, S, Patel, H, Warner, M, Yan Qi Tan, J, Iqbal, A, Khan, A, Perrin, K, Raza, A, Tan, S., and 2015 European Society of Coloproctology collaborating, Group

Subjects
creatinine blood level, adverse event, Disease, open surgery, surgery, 0302 clinical medicine, hospital readmission, postoperative complication, resection, Crohn's disease, Resection, Surgery, outcome, parenteral nutrition, postoperative complications, C reactive protein, adult, Gastroenterology, creatinine, Crohn disease, cohort analysis, female, priority journal, risk factor, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, abdominal abscess, anastomosis leakage, prospective study, medicine.medical_specialty, side to side anastomosis, surgical infection, reoperation, Anastomosis, Article, NO, 03 medical and health sciences, intestine resection, length of stay, male, medicine, intraoperative period, follow up, ileocecal resection, controlled study, human, Adverse effect, outcome assessment, preoperative period, ta3126, business.industry, Postoperative complication, Odds ratio, medicine.disease, surgical margin, major clinical study, Confidence interval, hemicolectomy, Parenteral nutrition, protein blood level, business, abscess drainage
Abstract

Aim: Patient- and disease-related factors, as well as operation technique, all have the potential to impact on postoperative outcome in Crohn's disease. The available evidence is based on small series and often displays conflicting results. The aim was to investigate the effect of preoperative and intra-operative risk factors on 30-day postoperative outcome in patients undergoing surgery for Crohn's disease. Method: This was an international prospective snapshot audit including consecutive patients undergoing right hemicolectomy or ileocaecal resection. The study analysed a subset of patients who underwent surgery for Crohn's disease. The primary outcome measure was the overall Clavien–Dindo postoperative complication rate. The key secondary outcomes were anastomotic leak, reoperation, surgical site infection and length of stay in hospital. Multivariable binary logistic regression analyses were used to produce odds ratios and 95% confidence intervals. Results: In all, 375 resections in 375 patients were included. The median age was 37 and 57.1% were women. In multivariate analyses, postoperative complications were associated with preoperative parenteral nutrition (OR 2.36, 95% CI 1.10–4.97), urgent/expedited surgical intervention (OR 2.00, 95% CI 1.13–3.55) and unplanned intra-operative adverse events (OR 2.30, 95% CI 1.20–4.45). The postoperative length of stay in hospital was prolonged in patients who received preoperative parenteral nutrition (OR 31, 95% CI 1.08–1.61) and those who had urgent/expedited operations (OR 1.21, 95% CI 1.07–1.37). Conclusion: Preoperative parenteral nutritional support, urgent/expedited operation and unplanned intra-operative adverse events were associated with unfavourable postoperative outcome. Enhanced preoperative optimization and improved planning of operation pathways and timings may improve outcomes for patients. Colorectal Disease © 2017 The Association of Coloproctology of Great Britain and Ireland

Published
2018

40. Andre presfaktorer end næringsstoffer og klimaforandringer

Author

Petersen, Jens Kjerulf, Holm, Andrea-Pil Sussie, Christensen, Asbjørn, Krekoukiotis, Dionysios, Jakobsen, H., Sanderson, H., Andreasen, Heidi, Gislason, Henrik, Strand, J., Behrens, Jane, Hansen, J. Würgler, Svendsen, Jon Christian, Timmermann, K., Møller, Lene Friis, Bach, L., Larsen, M. Mørk, Zrust, M., Nielsen, Mette Møller, Eigaard, Ole Ritzau, Nielsen, Pernille, Stæhr, P.A., Høgslund, S., Nielsen, Torkel Gissel, Petersen, Jens Kjerulf, Holm, Andrea-Pil Sussie, Christensen, Asbjørn, Krekoukiotis, Dionysios, Jakobsen, H., Sanderson, H., Andreasen, Heidi, Gislason, Henrik, Strand, J., Behrens, Jane, Hansen, J. Würgler, Svendsen, Jon Christian, Timmermann, K., Møller, Lene Friis, Bach, L., Larsen, M. Mørk, Zrust, M., Nielsen, Mette Møller, Eigaard, Ole Ritzau, Nielsen, Pernille, Stæhr, P.A., Høgslund, S., and Nielsen, Torkel Gissel

Published
2019

45. Editorial Acknowledgment

Author

Aarvak, T., Abedi-Valugerdi, M., Abrahamsen, T., Akdis, C., Akuffo, H.O., Alarcon-Riquelme, M., Andersen, P., Arstila, P., Austgulen, R., Baecker-Allan, C., Baggiolini, M., Baker, B.S., Bakke, O., Bakken, V., Barclay, A.N., Bemark, M., Benestad, H.B., Berzins, K., Bjerkvik, R., Bjørge, L., Bland, P., Bolstad, A.I., Born, W., Bowman, S., Brinchmann, J., Britton, S., Brokstad, K.A., Brunet, L.R., Bruserud, Ø., Cardona, P.J., Ceyppens, J.L., Cirino, G., Cohn, M., Cox, R.J., Cunliffe, J., Dahlgren, U., Dellacasagrande, J., Ditzel, H., Dobryszycka, E., Dyrhol-Riise, A.M., Edwards, J.C., Egeland, T., Elsayed, S., Eray, M., Erb, K.J., Esch, T., Eugen-Olsen, J., Everse, L.A., Fagerhol, M., Farstad, I., Feldmann, M., Fernandez, C., Fleck, M., Franksson, R., Freitas, A., Garred, P., Gidlund, M., Gilhus, N.E., Goldbach-Mansky, R., Gordon, J., Gordon, T., Grandien, A., Gregerson, P., Grewal, H., Hakulinen, J., Halstensen, T., Haneberg, B., Hanej, S.H.E., Hansen, T., Harley, J.B., Haukenes, G., Hengartner, H., Henz, B.M., Holen, E., Hurme, M., Husby, G., Husby, S., Hörnqvist-Hultgren, E., Haaheim, L.R., Isenberg, D., Jahnson, F., Jakobsen, H., James, J.A., Jansson, J.O., Jarva, H., Jeansson, S., Johannessen, A.C., Johansen, F.E., Julkunen, I., Kalland, K.H., Kaye, J., Kazatchkine, M., Kihlström, E., Kohler, L., Konttinen, Y., Kotenko, S., Koutzov, S., Krammer, P., Kristoffersen, E., Kunzendorf, U., Lachmann, P., Langman, R., Langner, J., Lanzavecchia, L., Lappalainen, M., Laskay, T., Lea, T., Lefvert, A.K., Lehmann, A.C., Louka, A, Lúdviksson, B.R., Mariette, X., Marion, T., Marker-Herrmann, E., Mattsson, R., McAdam, S., Mellbye, O.J., Mellgren, G., Mellgren, S.I., Mestecky, J., Michaelsen, T., Michalek, S., Miettinen, A., Moestrup, S.K., Moretta, A., Moser, M., Mountz, J., Moutsopoulos, H., Munthe, L.A., Mustafa, T., Myrmel, H., Nannemark, G., Netea, M.G., Nilsen, R., Notarangelo, L.D., Ögmundsdóttir, H., Olsson, I., Olweus, J., Osland, A., Paludan, S.R., Parsons, K.R., Patarroyo, M., Paul, W.E., Perlman, P., Pollock, J.M., Puolakkainen, M., Quale, A., Rajewsky, K., Raman, C., Reichlin, M., Renkonen, R., Rese Shadidi, K., Ricciardi-Castagnoli, P., Rickinson, A.B., Ringdén, O., Risto, R., Rodinov, D., Rosenkrands, I., Rottenberg, M., Russel, M., Rygaard, J., Rødahl, E., Röllinghof, M., Sandberg, M., Schenk, K., Seppälä, I., Shevach, E., Shortman, K., Siegrist, C.A., Sigurdardóttir, S., Silvennoinen, O., Sinigaglia, F., Sistonen, L., Skarstein, K., Skogh, T., Smith, E., Spurkland, A., Stendahl, O., Sugden, B., Suri-Payer, E., Svennerholm, A.M., Szodoray, P., Theofilopoulos, A., Thorley-Lawson, D.A., Timonen, T., Trowsdale, J., Tuomo, T., Ulmer, A.J., Ulvestad, E., Ulvik, R., Vaerman, J.P., van, der Merwe J.P., van Eden, W., Vedeler, C., Vintermyr, O.K., Vyse, J., Wahlgren, M., Wahren-Herlenius, M., Walsh, L.J., Weetman, A.P., Westermark, P., Wiker, H., Yang, J., Yewdell, J.W., Youinou, P., and Zouali, M.

Published
2002

46. Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection : an international snapshot audit

Author

Pinkney, T., Battersby, N., Bhangu, A., Chaudhri, S., El-Hussuna, A., Frasson, M., Nepogodiev, D., Singh, B., Vennix, S., Zmora, O., Altomare, D., Bemelman, W., Christensen, P., D'Hoore, A., Laurberg, S., Morton, D., Rubbini, M., Vaizey, C., Magill, L., Perry, R., Sheward, N., Ives, N., Mehta, S., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Salomon, M., Makhmudov, A., Selnyahina, L., Varabei, A., Vizhynis, Y., Claeys, D., Defoort, B., Muysoms, F., Pletinckx, P., Vergucht, V., Debergh, I., Feryn, T., Reusens, H., Nachtergaele, M., Francart, D., Jehaes, C., Markiewicz, S., Monami, B., Weerts, J., Bouckaert, W., Houben, Bert, Knol, Joep, Sergeant, Gregory, Vangertruyden, G., Haeck, L., Lange, C., Sommeling, C., Vindevoghel, K., Castro, S., De Bruyn, H., Huyghe, M., De Wolf, E., Reynders, D., van Overstraeten, A. de Buck, Wolthuis, A., Delibegovic, S., Christiani, A., Marchiori, M., Jr., Rocha de Moraes, C., Tercioti, V., Jr., Arabadjieva, E., Bulanov, D., Dardanov, D., Stoyanov, V., Yonkov, A., Angelov, K., Maslyankov, S., Sokolov, M., Todorov, G., Toshev, S., Georgiev, Y., Karashmalakov, A., Zafirov, G., Wang, X., Condic, D., Kraljik, D., Mrkovic, H., Pavkovic, V., Raguz, K., Bencurik, V., Holaskova, E., Skrovina, M., Farkasova, M., Grolich, T., Kala, Z., Antos, F., Pruchova, V., Sotona, O., Chobola, M., Dusek, T., Ferko, A., Orhalmi, J., Hoch, J., Kocian, P., Martinek, L., Bernstein, I., Sunesen, K. Gotschalck, Leunbach, J., Thorlacius-Ussing, O., Oveson, A. Uth, Chirstensen, S. Dahl, Gamez, V., Oeting, M., Loeve, U. Schou, Ugianskis, A., Jessen, M., Krarup, P., Linde, K., Mirza, Q., Stovring, J. Overgaard, Erritzoe, L., Jakobsen, H. Loft, Lykke, J., Colov, E. Palmgren, Madsen, A. Husted, Friis, T. Linde, Funder, J. Amstrup, Dich, R., Kjaer, S., Rasmussen, S., Schlesinger, N., Kjaer, M. Dilling, Qvist, N., Khalid, A., Ali, G., Hadi, S., Walker, L. Rosell, Kivela, A., Lehtonen, T., Lepisto, A., Scheinin, T., Siironen, P., Kossi, J., Kuusanmaki, P., Tomminen, T., Turunen, A., Rautio, T., Vierimaa, M., Huhtinen, H., Karvonen, J., Lavonius, M., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Kepenekian, V., Passot, G., Maggiori, L., Manceau, G., Panis, Y., Gout, M., Rullier, E., van Geluwe, B., Chafai, N., Lefevre, J. H., Parc, Y., Tiret, E., Couette, C., Duchalais, E., Agha, A., Hornberger, M., Hungbauer, A., Iesalnieks, I., Weindl, I., Crescenti, F., Keller, M., Kolodziejski, N., Scherer, R., Sterzing, D., Bock, B., Boehm, G., El-Magd, M., Krones, C., Niewiera, M., Buhr, J., Cordesmeyer, S., Hoffmann, M., Krueckemeier, K., Vogel, T., Schoen, M., Baral, J., Lukoschek, T., Muench, S., Pullig, F., Horisberger, K., Kienle, P., Magdeburg, J., Post, S., Batzalexis, K., Germanos, S., Agalianos, C., Dervenis, C., Gouvas, N., Kanavidis, P., Kottikias, A., Katsoulis, I. E., Korkolis, D., Plataniotis, G., Sakorafas, G., Akrida, I., Argentou, M., Kollatos, C., Lampropoulos, C., Tsochatzis, S., Besznyak, I., Bursics, A., Egyed, T., Papp, G., Svastics, I., Atladottir, J., Moller, P., Sigurdsson, H., Stefansson, T., Valsdottir, E., Andrews, E., Foley, N., Hechtl, D., Majeed, M., McCourt, M., Hanly, A., Hyland, J., Martin, S., O'Connell, P. 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M., Cuk, V. V., Kenic, M., Kovacevic, B., Krdzic, I., Korcek, J., Rems, M., Toplak, J., Escarrã¢, J., Gil Barrionuevo, M., Golda, T., Kreisler Moreno, E., Zerpa Martin, C., à lvarez Laso, C., Cumplido, P., Padin, H., Baixauli Fons, J., Hernández-Lizoain, J., Martinez-Ortega, P., Molina-Fernández, M., Sánchez-Justicia, C., Antonio Gracia Solanas, J., de Laspra, E. 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Ortiz, Ribas, R., Sabia, D., Viso, L., Alonso Gonçalves, S., José Gil Egea, M., Pascual Damieta, M., Pera, M., Salvans Ruiz, S., Bernal, J., Landete, F., Ais, G., Etreros, J., Aguiló Lucia, J., Boscã¡, A., Deusa, S., García del Caño, J., Viciano, V., García-Armengol, J., Roig, J., Blas, J., Escartin, J., Fatã¡s, J., Fernando, J., Ferrer, R., Arias Pacheco, R., García Flórez, L., Moreno Gijón, M., Otero Díez, J., Solar Garcia, L., Aguilar Teixido, F., Balaguer Ojo, C., Bargallo Berzosa, J., Lamas Moure, S., Enrique Sierra, J., Fermiã±ã¡n, A., Herrerias, F., Rufas, M., Viã±as, J., Codina-Cazador, A., Farrã©s, R., Gã³mez, N., Juliã , D., Planellas, P., Lã³pez, J., Luna, A., Maristany, C., Muñoz Duyos, A., Puã©rtolas, N., Alcantara Moral, M., Serra-Aracil, X., Concheiro Coello, P., Gã³mez, D., Carton, C., Miguel, A., Reoyo Pascual, F., Valero Cerrato, X., Zambrano Muñoz, R., Cervera-Aldama, J., García González, J., Ramos-Prada, J., Santamaría-Olabarrieta, M., Urigüen-Echeverría, A., Coves Alcover, R., Espinosa Soria, J., Fernandez Rodriguez, E., Hernandis Villalba, J., Maturana Ibañez, V., De la Torre Gonzalez, F., Huerga, D., Pérez Viejo, E., Rivera, A., Ruiz Ucar, E., Garcia-Septiem, J., Jimã©nez, V., Jiménez Miramón, J., Ramons Rodriquez, J., Rodriguez Alvarez, V., Garcea, A., Ponchietti, L., Borda, N., Enriquez-Navascues, J., Saralegui, Y., Febles Molina, G., Nogues, E., Rodríguez Méndez, Ã. ., Roque Castellano, C., Sosa Quesada, Y., Alvarez-Gallego, M., Pascual, I., Rubio-Perez, I., Diaz-San Andrés, B., Tone-Villanueva, F., Alonso, J., Cagigas, C., Castillo, J., Gã³mez, M., Martín-Parra, J., Mengual Ballester, M., Pellicer Franco, E., Soria Aledo, V., Valero Navarro, G., Caballero Rodríguez, E., De Chaves, P. 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B., Diaz López, C., Navarro Rodriguez, E., Torres Tordera, E., Arenal, J., Citores, M., Marcos, J., Sã¡nchez, J., Tinoco, C., Espin, E., Garcia Granero, A., Jimenez Gomez, L., Sanchez Garcia, J., Vallribera, F., Folkesson, J., Skã¶ldberg, F., Bergman, K., Borgstrã¶m, E., Frey, J., Silfverberg, A., Sã¶derholm, M., Nygren, J., Segelman, J., Gustafsson, D., Lagerqvist, A., Papp, A., Pelczar, M., Abraham-Nordling, M., Ahlberg, M., Sjovall, A., Tengstrom, J., Hagman, K., Chabok, A., Ezra, E., Nikberg, M., Smedh, K., Tiselius, C., Al-Naimi, N., Dao Duc, M., Meyer, J., Mormont, M., Ris, F., Prevost, G., Villiger, P., Hoffmann, H., Kettelhack, C., Kirchhoff, P., Oertli, D., Weixler, B., Aytac, B., Leventoglu, S., Mentes, B., Yuksel, O., Demirbas, S., Busra Ozkan, B., Selçuk Özbalci, G., Sungurtekin, U., Gã¼lcã¼, B., Ozturk, E., Yilmazlar, T., Challand, C., Fearnhead, N., Hubbard, R., Kumar, S., Arthur, J., Barben, C., Skaife, P., Slawik, S., Williams, M., Zammit, M., Barker, J., Sarantitis, I., Slawinski, C., Clifford, R., Eardley, N., Johnson, M., Mcfaul, C., Vimalachandran, D., Allan, S., Bell, A., Oates, E., Shanmugam, V., Brigic, A., Halls, M., Pucher, P., Stubbs, B., Agarwal, T., Chopada, A., Mallappa, S., Pathmarajah, M., Sugden, C., Brown, C., Macdonald, E., Mckay, A., Richards, J., Robertson, A., Kaushal, M., Patel, P., Tezas, S., Touqan, N., Ayaani, S., Marimuthu, K., Piramanayagam, B., Vourvachis, M., Iqbal, N., Korsgen, S., Seretis, C., Shariff, U., Arnold, S., Chan, H., Clark, E., Fernandes, R., Moran, B., Bajwa, A., Mcarthur, D., Cao, K., Cunha, P., Pardoe, H., Quddus, A., Theodoropoulou, K., Bolln, C., Denys, G., Gillespie, M., Manimaran, N., Reidy, J., Malik, A. 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A., Samaranayake, S. F., Warusavitarne, J., Arya, S., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Duff, S., Fatayer, T., Mbuvi, J., Sharma, A., Cornish, J., Davies, L., Harries, R., Morris, C., Torkington, J., Knight, J., Lai, C., Shihab, O., Tzivanakis, A., Hussain, A., Luke, D., Padwick, R., Torrance, A., Tsiamis, A., Dawson, P., Balfour, A., Brady, R., Mander, J., Paterson, H., Chandratreya, N., Chu, H., Cutting, J., Vernon, S., Wai Ho, C., Andreani, S., Patel, H., Yan Qi Tan, J., Iqbal, A., Khan, A., Perrin, K., Raza, A., Tan, S., Other departments, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer Treatment and Quality of Life, Surgery, Meyer, Jérémy, Al-Naimi, Noof, Mormont, Murielle, Ris, Frédéric, 2015 European Society of Coloproctology collaborating, Group, Rosati, R, Sileri, P, and Radiology and nuclear medicine

Subjects
medicine.medical_specialty, Leak, SURGERY, colorectal cancer, Audit, 030230 surgery, Anastomosis, Logistic regression, NO, Resection, 03 medical and health sciences, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Primary outcome, All institutes and research themes of the Radboud University Medical Center, Anastomotic leak, colorectal cancer, Crohn's disease, epidemiology, international, Journal Article, Medicine, Anastomotic leak, LEAK, COMPLICATIONS, ddc:617, business.industry, MORTALITY, Gastroenterology, Crohns disease, anastomotic leak, crohn's disease, epidemiology, international, ta3121, 3. Good health, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Crohn's disease, DEFINITION, 030220 oncology & carcinogenesis, Mixed effects, RISK-FACTORS, business, Right hemicolectomy
Abstract

Aim The anastomosis technique used following right-sided colonic resection is widely variable and may affect patient outcome. This study aimed to assess the association between leak and anastomosis technique (stapled vs handsewn)., Method This was a prospective, multicentre, international audit including patients undergoing elective or emergency right hemicolectomy or ileo-caecal resection operations over a 2-month period in early 2015. The primary outcome measure was the presence of anastomotic leak within 30 days of surgery, determined using a prespecified definition. Mixed effects logistic regression models were used to assess the association between leak and anastomosis method, adjusting for patient, disease and operative cofactors, with centre included as a random-effect variable., Results This study included 3208 patients, of whom 78.4% (n = 2515) underwent surgery for malignancy and 11.7% (n = 375) underwent surgery for Crohn's disease. An anastomosis was performed in 94.8% (n = 3041) of patients, which was handsewn in 38.9% (n = 1183) and stapled in 61.1% (n = 1858). Patients undergoing hand-sewn anastomosis were more likely to be emergency admissions (20.5% handsewn vs 12.9% stapled) and to undergo open surgery (54.7% handsewn vs 36.6% stapled). The overall anastomotic leak rate was 8.1% (245/3041), which was similar following handsewn (7.4%) and stapled (8.5%) techniques (P = 0.3). After adjustment for cofactors, the odds of a leak were higher for stapled anastomosis (adjusted OR = 1.43; 95% CI: 1.04-1.95; P = 0.03)., Conclusion Despite being used in lower-risk patients, stapled anastomosis was associated with an increased anastomotic leak rate in this observational study. Further research is needed to define patient groups in whom a stapled anastomosis is safe.

Published
2017

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