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709 results on '"Jakob, Michael"'

5. A Multi-agent Case-Based Reasoning Intrusion Detection System Prototype

Author

Schoenborn, Jakob Michael, Althoff, Klaus-Dieter, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Massie, Stewart, editor, and Chakraborti, Sutanu, editor

Published
2023
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6. Early kinetics of C reactive protein for cancer-agnostic prediction of therapy response and mortality in patients treated with immune checkpoint inhibitors: a multicenter cohort study

Author

Matthias Preusser, Erika Richtig, Florian Moik, Cihan Ay, Martin Pichler, Florian Posch, Armin Gerger, Lukas Koch, Thomas Bauernhofer, Thomas Winder, Dominik A Barth, Sarah Steinlechner, Marie-Christina Mayer, Amelie M Sandner, Franziska Berton, Verena Schlintl, Nikolaus John, Robert Wurm, Patrick Reimann, Christoph Wohlkönig, Philipp J Jost, Angelika Terbuch, and Jakob Michael Riedl

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background C reactive protein (CRP) kinetics have recently been suggested as predictive biomarkers for the efficacy of immune checkpoint inhibitor (ICI) therapy in selected cancer types. The aim of this study was to characterize early CRP kinetics as a tumor-agnostic biomarker for ICI treatment outcomes.Methods In this multicenter retrospective cohort study, two independent cohorts of patients with various cancer types undergoing palliative ICI treatment at Austrian academic centers served as the discovery (n=562) and validation cohort (n=474). Four different patterns of CRP kinetics in the first 3 months of ICI therapy were defined (CRP-flare responders, CRP-responders, CRP non-responders, patients with all-normal CRP). Objective response rate (ORR), progression-free survival (PFS) and overall survival (OS) were defined as coprimary endpoints. Univariable and multivariable logistic regression, landmark analysis and Cox regression including CRP kinetics as time-dependent variable were performed.Results The ORR in patients with all-normal CRP, CRP responders, CRP flare-responders and CRP non-responders was 41%, 38%, 31% and 12%, respectively. The median OS and PFS estimates were 24.5 months (95% CI 18.5 to not reached) and 8.2 months (95% CI 5.9 to 12.0) in patients with all-normal CRP, 16.1 months (95% CI 12.6 to 19-8) and 6.1 months (95% CI 4.9 to 7.2) in CRP-responders, 14.0 months (95% CI 8.5 to 19.4) and 5.7 months (95% CI 4.1 to 8.5) in CRP flare-responders and 8.1 months (95% CI 5.8 to 9.9) and 2.3 months (95% CI 2.2 to 2.8) in CRP non-responders (log-rank p for PFS and OS

Published
2023
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36. Troubleshooting

Author

Morschhäuser, Diana, Fischer, Wilhelm, Jakob, Michael, Morschhäuser, Diana, Fischer, Wilhelm, and Jakob, Michael

Published
2019
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37. Erweiterte Nachsorge

Author

Morschhäuser, Diana, Fischer, Wilhelm, Jakob, Michael, Morschhäuser, Diana, Fischer, Wilhelm, and Jakob, Michael

Published
2019
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38. Programmierung

Author

Morschhäuser, Diana, Fischer, Wilhelm, Jakob, Michael, Morschhäuser, Diana, Fischer, Wilhelm, and Jakob, Michael

Published
2019
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39. Komplikationen

Author

Morschhäuser, Diana, Fischer, Wilhelm, Jakob, Michael, Morschhäuser, Diana, Fischer, Wilhelm, and Jakob, Michael

Published
2019
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40. Diagnosefunktionen

Author

Morschhäuser, Diana, Fischer, Wilhelm, Jakob, Michael, Morschhäuser, Diana, Fischer, Wilhelm, and Jakob, Michael

Published
2019
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41. Basisnachsorge

Author

Morschhäuser, Diana, Fischer, Wilhelm, Jakob, Michael, Morschhäuser, Diana, Fischer, Wilhelm, and Jakob, Michael

Published
2019
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43. Schutzfunktionen

Author

Morschhäuser, Diana, Fischer, Wilhelm, Jakob, Michael, Morschhäuser, Diana, Fischer, Wilhelm, and Jakob, Michael

Published
2019
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44. Grundlagen

Author

Morschhäuser, Diana, Fischer, Wilhelm, Jakob, Michael, Morschhäuser, Diana, Fischer, Wilhelm, and Jakob, Michael

Published
2019
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47. The Political Economy of Coal

Author

Jakob, Michael and Steckel, Jan C.

Subjects
Applied ecology, Environmental management, Central / national / federal government policies, Environmental policy and protocols, Energy, Environmental science, engineering and technology, Climate change, bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNC Applied ecology, bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNF Environmental management, bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government::JPQB Central government policies, bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RND Environmental policy & protocols, bic Book Industry Communication::P Mathematics & science::PH Physics::PHD Classical mechanics::PHDY Energy, bic Book Industry Communication::T Technology, engineering, agriculture::TQ Environmental science, engineering & technology, bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNP Pollution & threats to the environment::RNPG Climate change
Abstract

This volume provides an overview of the political economy of coal in diverse country contexts. Coal is the largest source of greenhouse gas emissions globally, accounting for about 40 percent of energy-related CO2 emissions. Continued construction of coal-fired power plants could make the climate targets of the Paris Agreement infeasible to achieve. In spite of sharply declining costs for renewable energy sources, many countries still heavily rely on coal to meet their energy demand. The predominance of coal can only be adequately understood in light of the political factors that determine energy policy formulation. To this end, this edited volume assembles a wide variety of case studies exploring the political economy of coal for across the globe. These includes industrial and developing nations, coal importers and exporters as well as countries that are either substantial coal users, are just beginning to ramp up their capacities, or have already initiated a coal phase-out. Importantly, all case studies are structured along a unifying framework that focuses on the central actors driving energy policy formulation, their main objectives as well as the context that determines to what extent they can influence policy making. This large set of comparable studies will permit drawing conclusions regarding key similarities as well as differences driving coal use in different countries. This book will be of great interest to students and scholars of energy, climate change, resource management, and sustainable development. It will also appeal to practitioners and policymakers involved in sustainable development.

Published
2022
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