45 results on '"Jakob, Clarissa"'
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2. Discovery of Potent Azetidine-Benzoxazole MerTK Inhibitors with In VivoTarget Engagement
3. Discovery of A-910, a Highly Potent and Orally Bioavailable Dual MerTK/Axl-Selective Tyrosine Kinase Inhibitor
4. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
5. Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases
6. Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
7. A potent erythropoietin-mimicking human antibody interacts through a novel binding site
8. 4-Amino-5-aryl-6-arylethynylpyrimidines: Structure–activity relationships of non-nucleoside adenosine kinase inhibitors
9. The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen
10. Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig™) molecule
11. Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design
12. Structure-based Optimization of MurF Inhibitors
13. Ion binding induces closed conformation in Psuedomonas 7A glutaminase-asparaginase (PGA): crystal structure of the PGA-SO (sub 4)(super 2-)-NH4+ complex at 1.7 angstrom resolution
14. Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure
15. Characterization of protein kinase A phosphorylation: multi-technique approach to phosphate mapping
16. Why not wild-type IDH1? Finding novel chemical matter for the forgotten isotype
17. Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer
18. Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors
19. X-ray crystallographic structure of ABT-378 (Lopinavir) bound to HIV-1 protease
20. SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding
21. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315
22. Abstract LB-A23: Discovery of a potent catalytic p300/CBP inhibitor that targets lineage-specific tumors
23. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
24. Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors
25. Erratum: The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex
26. The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex
27. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
28. Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2
29. Crystal Structures of Human Adenosine Kinase Inhibitor Complexes Reveal Two Distinct Binding Modes
30. Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer
31. Discovery of trans-3,4′-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation
32. A highly potent and selective farnesyltransferase inhibitor ABT-100 in preclinical studies
33. Liver-Selective Glucocorticoid Antagonists: A Novel Treatment for Type 2 Diabetes.
34. Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors
35. Liver-Selective Glucocorticoid Antagonists: A Novel Treatment for Type 2 Diabetes
36. Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization
37. Design, Synthesis, and Biological Activity of 4-[(4-Cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as Potent and Selective Farnesyltransferase Inhibitors
38. The Three-dimensional Structures of Antagonistic and Agonistic Forms of the Glucocorticoid Receptor Ligand-binding Domain
39. Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency
40. Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives
41. Crystal Structure and Mutagenic Analysis of the Inhibitor-of-Apoptosis Protein Survivin
42. Crystal structure of human prostatic acid phosphatase
43. Ion Binding Induces Closed Conformation in Pseudomonas 7A Glutaminase-Asparaginase (PGA): Crystal Structure of the PGA-SO42--NH4+ Complex at 1.7 Å Resolution,
44. Crystallization and Prelimary Crystallographic Data for Formyltetrahydrofolate Synthetase from Clostridium thermoaceticum
45. Crystal Structures of Human Adenosine Kinase Inhibitor Complexes Reveal Two Distinct Binding Modes
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