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1. Genomic signatures of past and present chromosomal instability in Barrett’s esophagus and early esophageal adenocarcinoma

Author

Bao, Chunyang, Tourdot, Richard W, Brunette, Gregory J, Stewart, Chip, Sun, Lili, Baba, Hideo, Watanabe, Masayuki, Agoston, Agoston T, Jajoo, Kunal, Davison, Jon M, Nason, Katie S, Getz, Gad, Wang, Kenneth K, Imamura, Yu, Odze, Robert, Bass, Adam J, Stachler, Matthew D, and Zhang, Cheng-Zhong

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Human Genome, Rare Diseases, Cancer, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Humans, Barrett Esophagus, Esophageal Neoplasms, Adenocarcinoma, Chromosomal Instability, Precancerous Conditions, Genomics, Disease Progression
Abstract

The progression of precancerous lesions to malignancy is often accompanied by increasing complexity of chromosomal alterations but how these alterations arise is poorly understood. Here we perform haplotype-specific analysis of chromosomal copy-number evolution in the progression of Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) on multiregional whole-genome sequencing data of BE with dysplasia and microscopic EAC foci. We identify distinct patterns of copy-number evolution indicating multigenerational chromosomal instability that is initiated by cell division errors but propagated only after p53 loss. While abnormal mitosis, including whole-genome duplication, underlies chromosomal copy-number changes, segmental alterations display signatures of successive breakage-fusion-bridge cycles and chromothripsis of unstable dicentric chromosomes. Our analysis elucidates how multigenerational chromosomal instability generates copy-number variation in BE cells, precipitates complex alterations including DNA amplifications, and promotes their independent clonal expansion and transformation. In particular, we suggest sloping copy-number variation as a signature of ongoing chromosomal instability that precedes copy-number complexity. These findings suggest copy-number heterogeneity in advanced cancers originates from chromosomal instability in precancerous cells and such instability may be identified from the presence of sloping copy-number variation in bulk sequencing data.

Published
2023

2. A blood-based metabolomic signature predictive of risk for pancreatic cancer

Author

Irajizad, Ehsan, Kenney, Ana, Tang, Tiffany, Vykoukal, Jody, Wu, Ranran, Murage, Eunice, Dennison, Jennifer B., Sans, Marta, Long, James P., Loftus, Maureen, Chabot, John A., Kluger, Michael D., Kastrinos, Fay, Brais, Lauren, Babic, Ana, Jajoo, Kunal, Lee, Linda S., Clancy, Thomas E., Ng, Kimmie, Bullock, Andrea, Genkinger, Jeanine M., Maitra, Anirban, Do, Kim-Anh, Yu, Bin, Wolpin, Brian M., Hanash, Sam, and Fahrmann, Johannes F.

Published
2023
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4. Lead-Time Trajectory of CA19-9 as an Anchor Marker for Pancreatic Cancer Early Detection

Author

Fahrmann, Johannes F., Schmidt, C. Max, Mao, Xiangying, Irajizad, Ehsan, Loftus, Maureen, Zhang, Jinming, Patel, Nikul, Vykoukal, Jody, Dennison, Jennifer B., Long, James P., Do, Kim-Anh, Zhang, Jianjun, Chabot, John A., Kluger, Michael D., Kastrinos, Fay, Brais, Lauren, Babic, Ana, Jajoo, Kunal, Lee, Linda S., Clancy, Thomas E., Ng, Kimmie, Bullock, Andrea, Genkinger, Jeanine, Yip-Schneider, Michele T., Maitra, Anirban, Wolpin, Brian M., and Hanash, Samir

Published
2021
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5. Gastrointestinal Hemorrhage: A Manifestation of the Telomere Biology Disorders

Author

Himes, Ryan W., Chiou, Eric H., Queliza, Karen, Shouval, Dror S., Somech, Raz, Agarwal, Suneet, Jajoo, Kunal, Ziegler, David S., Kratz, Christian P., Huang, James, Lucas, Tiffany L., Myers, Kasiani C., Nelson, Adam S., DiNardo, Courtney D., Alter, Blanche P., Giri, Neelam, Khincha, Payal P., McReynolds, Lisa J., Dufour, Carlo, Pierri, Filomena, Goldman, Frederick D., Sherif, Youmna, Savage, Sharon A., Miloh, Tamir, and Bertuch, Alison A.

Published
2021
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7. Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer

Author

Ben-Ami, Roni, primary, Wang, Qiao-Li, additional, Zhang, Jinming, additional, Supplee, Julianna G, additional, Fahrmann, Johannes F, additional, Lehmann-Werman, Roni, additional, Brais, Lauren K, additional, Nowak, Jonathan, additional, Yuan, Chen, additional, Loftus, Maureen, additional, Babic, Ana, additional, Irajizad, Ehsan, additional, Davidi, Tal, additional, Zick, Aviad, additional, Hubert, Ayala, additional, Neiman, Daniel, additional, Piyanzin, Sheina, additional, Gal-Rosenberg, Ofer, additional, Horn, Amit, additional, Shemer, Ruth, additional, Glaser, Benjamin, additional, Boos, Natalia, additional, Jajoo, Kunal, additional, Lee, Linda, additional, Clancy, Thomas E, additional, Rubinson, Douglas A, additional, Ng, Kimmie, additional, Chabot, John A, additional, Kastrinos, Fay, additional, Kluger, Michael, additional, Aguirre, Andrew J, additional, Jänne, Pasi A, additional, Bardeesy, Nabeel, additional, Stanger, Ben, additional, O'Hara, Mark H, additional, Till, Jacob, additional, Maitra, Anirban, additional, Carpenter, Erica L, additional, Bullock, Andrea J, additional, Genkinger, Jeanine, additional, Hanash, Samir M, additional, Paweletz, Cloud P, additional, Dor, Yuval, additional, and Wolpin, Brian M, additional

Published
2023
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11. S537 A Multicenter Retrospective Evaluation of the Clinical Performance and Safety of an Enhanced 16 Fr CryoDecompression Tube for Use in Liquid Nitrogen Spray Cryotherapy

Author

Kaul, Vivek, primary, Barber, Jeremy, additional, Battish, Raman, additional, Coyle, Walter, additional, Dumot, John, additional, Gordon, Stuart R., additional, Gupta, Saurabh, additional, Jajoo, Kunal, additional, Kothari, Shivangi, additional, Mok, Shaffer R. S., additional, Moremen, Jacob, additional, Robillard, Kevin, additional, Sceusi, Eric, additional, Sharma, Neil R., additional, Smith, Michael S., additional, Tsai, Franklin, additional, Vargo, John, additional, Vashi, Pankaj, additional, Zolotarevsky, Eugene, additional, and Greenwald, Bruce, additional

Published
2023
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13. Understanding the evolving phenotype of vascular complications in telomere biology disorders

Author

Higgs, Cecilia, Crow, Yanick J., Adams, Denise M., Chang, Emmanuel, Hayes, Jr., Don, Herbig, Utz, Huang, James N., Himes, Ryan, Jajoo, Kunal, Johnson, F. Brad, Reynolds, Susan D., Yonekawa, Yoshihiro, Armanios, Mary, Boulad, Farid, DiNardo, Courtney D., Dufour, Carlo, Goldman, Frederick D., Khan, Shakila, Kratz, Christian, Myers, Kasiani C., Raghu, Ganesh, Alter, Blanche P., Aubert, Geraldine, Bhala, Sonia, Cowen, Edward W., Dror, Yigal, El-Youssef, Mounif, Friedman, Bruce, Giri, Neelam, Helms Guba, Lisa, Khincha, Payal P., Lin, Tiffany F., Longhurst, Hilary, McReynolds, Lisa J., Nelson, Adam, Olson, Tim, Pariser, Anne, Perona, Rosario, Sasa, Ghadir, Schratz, Kristen, Simonetto, Douglas A., Townsley, Danielle, Walsh, Michael, Stevens, Katherine, Agarwal, Suneet, Bertuch, Alison A., Savage, Sharon A., and the Clinical Care Consortium for Telomere-associated Ailments (CCCTAA)

Published
2019
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16. Data from Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

Author

Aguirre, Andrew J., primary, Nowak, Jonathan A., primary, Camarda, Nicholas D., primary, Moffitt, Richard A., primary, Ghazani, Arezou A., primary, Hazar-Rethinam, Mehlika, primary, Raghavan, Srivatsan, primary, Kim, Jaegil, primary, Brais, Lauren K., primary, Ragon, Dorisanne, primary, Welch, Marisa W., primary, Reilly, Emma, primary, McCabe, Devin, primary, Marini, Lori, primary, Anderka, Kristin, primary, Helvie, Karla, primary, Oliver, Nelly, primary, Babic, Ana, primary, Da Silva, Annacarolina, primary, Nadres, Brandon, primary, Van Seventer, Emily E., primary, Shahzade, Heather A., primary, St. Pierre, Joseph P., primary, Burke, Kelly P., primary, Clancy, Thomas, primary, Cleary, James M., primary, Doyle, Leona A., primary, Jajoo, Kunal, primary, McCleary, Nadine J., primary, Meyerhardt, Jeffrey A., primary, Murphy, Janet E., primary, Ng, Kimmie, primary, Patel, Anuj K., primary, Perez, Kimberly, primary, Rosenthal, Michael H., primary, Rubinson, Douglas A., primary, Ryou, Marvin, primary, Shapiro, Geoffrey I., primary, Sicinska, Ewa, primary, Silverman, Stuart G., primary, Nagy, Rebecca J., primary, Lanman, Richard B., primary, Knoerzer, Deborah, primary, Welsch, Dean J., primary, Yurgelun, Matthew B., primary, Fuchs, Charles S., primary, Garraway, Levi A., primary, Getz, Gad, primary, Hornick, Jason L., primary, Johnson, Bruce E., primary, Kulke, Matthew H., primary, Mayer, Robert J., primary, Miller, Jeffrey W., primary, Shyn, Paul B., primary, Tuveson, David A., primary, Wagle, Nikhil, primary, Yeh, Jen Jen, primary, Hahn, William C., primary, Corcoran, Ryan B., primary, Carter, Scott L., primary, and Wolpin, Brian M., primary

Published
2023
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17. MAF file for CNVs from Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

Author

Aguirre, Andrew J., primary, Nowak, Jonathan A., primary, Camarda, Nicholas D., primary, Moffitt, Richard A., primary, Ghazani, Arezou A., primary, Hazar-Rethinam, Mehlika, primary, Raghavan, Srivatsan, primary, Kim, Jaegil, primary, Brais, Lauren K., primary, Ragon, Dorisanne, primary, Welch, Marisa W., primary, Reilly, Emma, primary, McCabe, Devin, primary, Marini, Lori, primary, Anderka, Kristin, primary, Helvie, Karla, primary, Oliver, Nelly, primary, Babic, Ana, primary, Da Silva, Annacarolina, primary, Nadres, Brandon, primary, Van Seventer, Emily E., primary, Shahzade, Heather A., primary, St. Pierre, Joseph P., primary, Burke, Kelly P., primary, Clancy, Thomas, primary, Cleary, James M., primary, Doyle, Leona A., primary, Jajoo, Kunal, primary, McCleary, Nadine J., primary, Meyerhardt, Jeffrey A., primary, Murphy, Janet E., primary, Ng, Kimmie, primary, Patel, Anuj K., primary, Perez, Kimberly, primary, Rosenthal, Michael H., primary, Rubinson, Douglas A., primary, Ryou, Marvin, primary, Shapiro, Geoffrey I., primary, Sicinska, Ewa, primary, Silverman, Stuart G., primary, Nagy, Rebecca J., primary, Lanman, Richard B., primary, Knoerzer, Deborah, primary, Welsch, Dean J., primary, Yurgelun, Matthew B., primary, Fuchs, Charles S., primary, Garraway, Levi A., primary, Getz, Gad, primary, Hornick, Jason L., primary, Johnson, Bruce E., primary, Kulke, Matthew H., primary, Mayer, Robert J., primary, Miller, Jeffrey W., primary, Shyn, Paul B., primary, Tuveson, David A., primary, Wagle, Nikhil, primary, Yeh, Jen Jen, primary, Hahn, William C., primary, Corcoran, Ryan B., primary, Carter, Scott L., primary, and Wolpin, Brian M., primary

Published
2023
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18. Supplementary Table S3 from Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

Author

Aguirre, Andrew J., primary, Nowak, Jonathan A., primary, Camarda, Nicholas D., primary, Moffitt, Richard A., primary, Ghazani, Arezou A., primary, Hazar-Rethinam, Mehlika, primary, Raghavan, Srivatsan, primary, Kim, Jaegil, primary, Brais, Lauren K., primary, Ragon, Dorisanne, primary, Welch, Marisa W., primary, Reilly, Emma, primary, McCabe, Devin, primary, Marini, Lori, primary, Anderka, Kristin, primary, Helvie, Karla, primary, Oliver, Nelly, primary, Babic, Ana, primary, Da Silva, Annacarolina, primary, Nadres, Brandon, primary, Van Seventer, Emily E., primary, Shahzade, Heather A., primary, St. Pierre, Joseph P., primary, Burke, Kelly P., primary, Clancy, Thomas, primary, Cleary, James M., primary, Doyle, Leona A., primary, Jajoo, Kunal, primary, McCleary, Nadine J., primary, Meyerhardt, Jeffrey A., primary, Murphy, Janet E., primary, Ng, Kimmie, primary, Patel, Anuj K., primary, Perez, Kimberly, primary, Rosenthal, Michael H., primary, Rubinson, Douglas A., primary, Ryou, Marvin, primary, Shapiro, Geoffrey I., primary, Sicinska, Ewa, primary, Silverman, Stuart G., primary, Nagy, Rebecca J., primary, Lanman, Richard B., primary, Knoerzer, Deborah, primary, Welsch, Dean J., primary, Yurgelun, Matthew B., primary, Fuchs, Charles S., primary, Garraway, Levi A., primary, Getz, Gad, primary, Hornick, Jason L., primary, Johnson, Bruce E., primary, Kulke, Matthew H., primary, Mayer, Robert J., primary, Miller, Jeffrey W., primary, Shyn, Paul B., primary, Tuveson, David A., primary, Wagle, Nikhil, primary, Yeh, Jen Jen, primary, Hahn, William C., primary, Corcoran, Ryan B., primary, Carter, Scott L., primary, and Wolpin, Brian M., primary

Published
2023
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19. Supplementary Experimental Methods from Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

Author

Aguirre, Andrew J., primary, Nowak, Jonathan A., primary, Camarda, Nicholas D., primary, Moffitt, Richard A., primary, Ghazani, Arezou A., primary, Hazar-Rethinam, Mehlika, primary, Raghavan, Srivatsan, primary, Kim, Jaegil, primary, Brais, Lauren K., primary, Ragon, Dorisanne, primary, Welch, Marisa W., primary, Reilly, Emma, primary, McCabe, Devin, primary, Marini, Lori, primary, Anderka, Kristin, primary, Helvie, Karla, primary, Oliver, Nelly, primary, Babic, Ana, primary, Da Silva, Annacarolina, primary, Nadres, Brandon, primary, Van Seventer, Emily E., primary, Shahzade, Heather A., primary, St. Pierre, Joseph P., primary, Burke, Kelly P., primary, Clancy, Thomas, primary, Cleary, James M., primary, Doyle, Leona A., primary, Jajoo, Kunal, primary, McCleary, Nadine J., primary, Meyerhardt, Jeffrey A., primary, Murphy, Janet E., primary, Ng, Kimmie, primary, Patel, Anuj K., primary, Perez, Kimberly, primary, Rosenthal, Michael H., primary, Rubinson, Douglas A., primary, Ryou, Marvin, primary, Shapiro, Geoffrey I., primary, Sicinska, Ewa, primary, Silverman, Stuart G., primary, Nagy, Rebecca J., primary, Lanman, Richard B., primary, Knoerzer, Deborah, primary, Welsch, Dean J., primary, Yurgelun, Matthew B., primary, Fuchs, Charles S., primary, Garraway, Levi A., primary, Getz, Gad, primary, Hornick, Jason L., primary, Johnson, Bruce E., primary, Kulke, Matthew H., primary, Mayer, Robert J., primary, Miller, Jeffrey W., primary, Shyn, Paul B., primary, Tuveson, David A., primary, Wagle, Nikhil, primary, Yeh, Jen Jen, primary, Hahn, William C., primary, Corcoran, Ryan B., primary, Carter, Scott L., primary, and Wolpin, Brian M., primary

Published
2023
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20. MAF file for mutations from Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

Author

Aguirre, Andrew J., primary, Nowak, Jonathan A., primary, Camarda, Nicholas D., primary, Moffitt, Richard A., primary, Ghazani, Arezou A., primary, Hazar-Rethinam, Mehlika, primary, Raghavan, Srivatsan, primary, Kim, Jaegil, primary, Brais, Lauren K., primary, Ragon, Dorisanne, primary, Welch, Marisa W., primary, Reilly, Emma, primary, McCabe, Devin, primary, Marini, Lori, primary, Anderka, Kristin, primary, Helvie, Karla, primary, Oliver, Nelly, primary, Babic, Ana, primary, Da Silva, Annacarolina, primary, Nadres, Brandon, primary, Van Seventer, Emily E., primary, Shahzade, Heather A., primary, St. Pierre, Joseph P., primary, Burke, Kelly P., primary, Clancy, Thomas, primary, Cleary, James M., primary, Doyle, Leona A., primary, Jajoo, Kunal, primary, McCleary, Nadine J., primary, Meyerhardt, Jeffrey A., primary, Murphy, Janet E., primary, Ng, Kimmie, primary, Patel, Anuj K., primary, Perez, Kimberly, primary, Rosenthal, Michael H., primary, Rubinson, Douglas A., primary, Ryou, Marvin, primary, Shapiro, Geoffrey I., primary, Sicinska, Ewa, primary, Silverman, Stuart G., primary, Nagy, Rebecca J., primary, Lanman, Richard B., primary, Knoerzer, Deborah, primary, Welsch, Dean J., primary, Yurgelun, Matthew B., primary, Fuchs, Charles S., primary, Garraway, Levi A., primary, Getz, Gad, primary, Hornick, Jason L., primary, Johnson, Bruce E., primary, Kulke, Matthew H., primary, Mayer, Robert J., primary, Miller, Jeffrey W., primary, Shyn, Paul B., primary, Tuveson, David A., primary, Wagle, Nikhil, primary, Yeh, Jen Jen, primary, Hahn, William C., primary, Corcoran, Ryan B., primary, Carter, Scott L., primary, and Wolpin, Brian M., primary

Published
2023
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21. Supplementary Figures from Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

Author

Aguirre, Andrew J., primary, Nowak, Jonathan A., primary, Camarda, Nicholas D., primary, Moffitt, Richard A., primary, Ghazani, Arezou A., primary, Hazar-Rethinam, Mehlika, primary, Raghavan, Srivatsan, primary, Kim, Jaegil, primary, Brais, Lauren K., primary, Ragon, Dorisanne, primary, Welch, Marisa W., primary, Reilly, Emma, primary, McCabe, Devin, primary, Marini, Lori, primary, Anderka, Kristin, primary, Helvie, Karla, primary, Oliver, Nelly, primary, Babic, Ana, primary, Da Silva, Annacarolina, primary, Nadres, Brandon, primary, Van Seventer, Emily E., primary, Shahzade, Heather A., primary, St. Pierre, Joseph P., primary, Burke, Kelly P., primary, Clancy, Thomas, primary, Cleary, James M., primary, Doyle, Leona A., primary, Jajoo, Kunal, primary, McCleary, Nadine J., primary, Meyerhardt, Jeffrey A., primary, Murphy, Janet E., primary, Ng, Kimmie, primary, Patel, Anuj K., primary, Perez, Kimberly, primary, Rosenthal, Michael H., primary, Rubinson, Douglas A., primary, Ryou, Marvin, primary, Shapiro, Geoffrey I., primary, Sicinska, Ewa, primary, Silverman, Stuart G., primary, Nagy, Rebecca J., primary, Lanman, Richard B., primary, Knoerzer, Deborah, primary, Welsch, Dean J., primary, Yurgelun, Matthew B., primary, Fuchs, Charles S., primary, Garraway, Levi A., primary, Getz, Gad, primary, Hornick, Jason L., primary, Johnson, Bruce E., primary, Kulke, Matthew H., primary, Mayer, Robert J., primary, Miller, Jeffrey W., primary, Shyn, Paul B., primary, Tuveson, David A., primary, Wagle, Nikhil, primary, Yeh, Jen Jen, primary, Hahn, William C., primary, Corcoran, Ryan B., primary, Carter, Scott L., primary, and Wolpin, Brian M., primary

Published
2023
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23. Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer

Author

Ben-Ami, Roni, Wang, Qiao-Li, Zhang, Jinming, Supplee, Julianna G, Fahrmann, Johannes F, Lehmann-Werman, Roni, Brais, Lauren K, Nowak, Jonathan, Yuan, Chen, Loftus, Maureen, Babic, Ana, Irajizad, Ehsan, Davidi, Tal, Zick, Aviad, Hubert, Ayala, Neiman, Daniel, Piyanzin, Sheina, Gal-Rosenberg, Ofer, Horn, Amit, Shemer, Ruth, Glaser, Benjamin, Boos, Natalia, Jajoo, Kunal, Lee, Linda, Clancy, Thomas E, Rubinson, Douglas A, Ng, Kimmie, Chabot, John A, Kastrinos, Fay, Kluger, Michael, Aguirre, Andrew J, Ja¨nne, Pasi A, Bardeesy, Nabeel, Stanger, Ben, O'Hara, Mark H, Till, Jacob, Maitra, Anirban, Carpenter, Erica L, Bullock, Andrea J, Genkinger, Jeanine, Hanash, Samir M, Paweletz, Cloud P, Dor, Yuval, and Wolpin, Brian M

Abstract

ObjectivePancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed at an advanced stage. Liquid biopsy approaches may facilitate detection of early stage PDAC when curative treatments can be employed.DesignTo assess circulating marker discrimination in training, testing and validation patient cohorts (total n=426 patients), plasma markers were measured among PDAC cases and patients with chronic pancreatitis, colorectal cancer (CRC), and healthy controls. Using CA19-9 as an anchor marker, measurements were made of two protein markers (TIMP1, LRG1) and cell-free DNA (cfDNA) pancreas-specific methylation at 9 loci encompassing 61 CpG sites.ResultsComparative methylome analysis identified nine loci that were differentially methylated in exocrine pancreas DNA. In the training set (n=124 patients), cfDNA methylation markers distinguished PDAC from healthy and CRC controls. In the testing set of 86 early stage PDAC and 86 matched healthy controls, CA19-9 had an area under the receiver operating characteristic curve (AUC) of 0.88 (95% CI 0.83 to 0.94), which was increased by adding TIMP1 (AUC 0.92; 95% CI 0.88 to 0.96; p=0.06), LRG1 (AUC 0.92; 95% CI 0.88 to 0.96; p=0.02) or exocrine pancreas-specific cfDNA methylation markers at nine loci (AUC 0.92; 95% CI 0.88 to 0.96; p=0.02). In the validation set of 40 early stage PDAC and 40 matched healthy controls, a combined panel including CA19-9, TIMP1 and a 9-loci cfDNA methylation panel had greater discrimination (AUC 0.86, 95% CI 0.77 to 0.95) than CA19-9 alone (AUC 0.82; 95% CI 0.72 to 0.92).ConclusionA combined panel of circulating markers including proteins and methylated cfDNA increased discrimination compared with CA19-9 alone for early stage PDAC.

Published
2024
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25. Abstract P076: Contribution of the microbiome to a metabolomic signature predictive of risk for pancreatic cancer

Author

Fahrmann, Johannes F., primary, Irajizad, Ehsan, additional, Kenney, Ana, additional, Tang, Tiffany, additional, Vykoukal, Jody, additional, Wu, Ranran, additional, Dennison, Jennifer B., additional, Escofet, Marta Sans, additional, Long, James P., additional, Loftus, Maureen, additional, Chabot, John A., additional, Kluger, Michael D., additional, Kastrinos, Fay, additional, Brais, Lauren, additional, Babic, Ana, additional, Jajoo, Kunal, additional, Lee, Linda S., additional, Clancy, Thomas E., additional, Ng, Kimmie, additional, Bullock, Andrea, additional, Genkinger, Jeanine M., additional, Maitra, Anirban, additional, Do, Kim-Anh, additional, Yu, Bin, additional, Wolpin, Brian M., additional, and Hanash, Samir, additional

Published
2023
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38. Endoscopically Injectable Shear‐Thinning Hydrogels Facilitating Polyp Removal

Author

Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology. Division of Comparative Medicine, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Mechanical Engineering, Pang, Yan, Liu, Jinyao, Moussa, Zaina L, Collins, Joy E, McDonnell, Shane, Hayward, Alison M, Jajoo, Kunal, Langer, Robert, Traverso, Giovanni, Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology. Division of Comparative Medicine, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Mechanical Engineering, Pang, Yan, Liu, Jinyao, Moussa, Zaina L, Collins, Joy E, McDonnell, Shane, Hayward, Alison M, Jajoo, Kunal, Langer, Robert, and Traverso, Giovanni

Abstract

© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Submucosal elevation, the process of instilling material in the submucosal space for separation of the surface mucosa and deeper muscularis layer, is a significant aspect of the endoscopic mucosal resection of large lesions performed to facilitate lesion removal and maximize safety. Submucosal injection, when applied, has historically been performed with normal saline, though this is limited by its rapid dissipation; solutions ideally need to be easily injectable, biocompatible, and provide a long-lasting submucosal cushion with a desirable height. Here, reported is a new set of materials, endoscopically injectable shear-thinning hydrogels, meeting these requirements because of their biocompatible components and ability to form a solid hydrogel upon injection. These findings are supported by evaluation in a large animal model and ultimately demonstrate the potential of these shear-thinning hydrogels to serve as efficient submucosal injection fluids for cushion development. Given these unique characteristics, their broad application in mucosal resection techniques is anticipated.

Published
2021

42. Prevalence and impact of Clostridioides difficile infection among hospitalized patients with coranavirus disease 201 9

Author

Allegretti, Jessica R, primary, Nije, Cheikh, additional, McClure, Emma, additional, Redd, Walker D, additional, Wong, Danny, additional, Zhou, Joyce C, additional, Bazarbashi, Ahmad N, additional, McCarty, Thomas R, additional, Hathorn, Kelly E, additional, Shen, Lin, additional, Jajoo, Kunal, additional, and Chan, Walter W, additional

Published
2021
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45. List of Contributors

Author

Adler, Douglas G., primary, Ahlawat, Sushil K., additional, Ahmad, Jawad, additional, Al-Kawas, Firas H., additional, Alsulaiman, Raed M., additional, Ang, Tiing Leong, additional, Baillie, John, additional, Barkun, Alan, additional, Baron, Todd H., additional, Bhandari, Suryaprakash, additional, Binmoeller, Kenneth F., additional, Brugge, William R., additional, Buscaglia, Jonathan M., additional, Carr-Locke, David L., additional, Chan, Annie On-On, additional, Chang, Suyi, additional, Chen, Ann M., additional, Costamagna, Guido, additional, De Palma, Giovanni D., additional, Deviere, Jacques, additional, Farrell, James J., additional, Fockens, Paul, additional, Fox, Victor L., additional, Frakes, James T., additional, Freeman, Martin L., additional, Geenen, Joseph E., additional, Ginsberg, Gregory G., additional, Gobelet, Jaquelina M., additional, Goh, Khean-Lee, additional, Guda, Nalini M, additional, Hawes, Robert H., additional, Hochberger, Jürgen, additional, Jajoo, Kunal, additional, Joyce, Ann Marie, additional, Kalloo, Anthony N., additional, Kelsey, Peter B., additional, Kimmey, Michael B., additional, Kochman, Michael L., additional, Kodama, Tadashi, additional, Koshitani, Tatsuya, additional, Kozarek, Richard A., additional, Lee, Yuk Tong, additional, Lehman, Glen A., additional, Leung, Joseph W., additional, Liu, Chi Leung, additional, Lo, Simon K., additional, Maiss, Jürgen, additional, Maydeo, Amit, additional, Menke, Detlev, additional, Morgan, Desiree E., additional, Navarrete, Claudio, additional, Neuhaus, Horst, additional, Ong, Wai Choung, additional, Outlaw, William M., additional, Petersen, Bret T., additional, Ponsky, Jeffrey L., additional, Venkat Rao, G., additional, Reddy, Nageshwar, additional, Rupa, Banerjee, additional, Seewald, Stefan, additional, Seo, Dong Wan, additional, Shah, Syed G., additional, Sherman, Stuart, additional, Shim, Chan-Sup, additional, Shimpi, Lalit, additional, Singh, Hardeep M., additional, Slivka, Adam, additional, Soehendra, Nib, additional, van Soest, Ellert J., additional, Spencer, Geoffrey, additional, Sung, Joseph, additional, Tarnasky, Paul R., additional, Tatsumi, Yoshihide, additional, Topazian, Mark, additional, Valdivieso, Eduardo, additional, Watkins, James L, additional, Wong, Benjamin Chun-Yu, additional, and Zuccaro, Gregory, additional

Published
2008
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48. S0164 Clostridioides difficile Infection in COVID-19 Patients

Author

Allegretti, Jessica R., primary, Njie, Cheikh, additional, McClure, Emma, additional, Redd, Walker D., additional, Wong, Danny, additional, Zhou, Joyce C., additional, Bazarbashi, Ahmad Najdat, additional, McCarty, Thomas R., additional, Hathorn, Kelly E., additional, Shen, Lin, additional, Jajoo, Kunal, additional, and Chan, Walter W., additional

Published
2020
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