136 results on '"Jajic I"'
Search Results
2. Preliminary Analysis of Data Mining Adoption in Italian SMEs Using PLS-SEM Method
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Bach, M. Pejic, primary, Topalovic, A., additional, and Jajic, I., additional
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- 2022
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3. Whom to treat? The contribution of vertebral X-rays to risk-based algorithms for fracture prediction. Results from the European Prospective Osteoporosis Study
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Kaptoge, S., Armbrecht, G., Felsenberg, D., Lunt, M., Weber, K., Boonen, S., Jajic, I., Stepan, J. J., Banzer, D., Reisinger, W., Janott, J., Kragl, G., Scheidt-Nave, C., Felsch, B., Matthis, C., Raspe, H. H., Lyritis, G., Póor, G, Nuti, R., Miazgowski, T., Hoszowski, K., Armas, J. Bruges, Vaz, A. Lopes, Benevolenskaya, L. I., Masaryk, P., Cannata, J. B., Johnell, O., Reid, D. M., Bhalla, A., Woolf, A. D., Todd, C. J., Cooper, C., Eastell, R., Kanis, J. A., O’Neill, T. W., Silman, A. J., and Reeve, J.
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- 2006
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4. Determinants of incident vertebral fracture in men and women: results from the European Prospective Osteoporosis Study (EPOS)
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Roy, D.K., O'Neill, T.W., Finn, J.D., Lunt, M., Silman, A.J., Felsenberg, D., Armbrecht, G., Banzer, D., Benevolenskaya, L.I., Bhalla, A., Bruges Armas, J., Cannata, J.B., Cooper, C., Dequeker, J., Diaz, M.N., Eastell, R., Yershova, O.B., Felsch, B., Gowin, W., Havelka, S., Hoszowski, K., Ismail, A.A., Jajic, I., Janott, I., Johnell, O., Kanis, J.A., Kragl, G., Lopez Vaz, A., Lorenc, R., Lyritis, G., Masaryk, P., Matthis, C., Miazgowski, T., Gennari, C., Pols, H.A.P., Poor, G., Raspe, H.H., Reid, D.M., Reisinger, W., Scheidt-Nave, C., Stepan, J.J., Todd, C.J., Weber, K., Woolf, A.D., and Reeve, J.
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- 2003
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5. Incidence of Limb Fracture across Europe: Results from the European Prospective Osteoporosis Study (EPOS)
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Ismail, A. A., Pye, S. R., Cockerill, W. C., Lunt, M., Silman*, A. J., Reeve*, J., Banzer, D., Benevolenskaya, L. I., Bhalla, A., Bruges Armas, J., Cannata, J. B., Cooper, C., Delmas, P. D., Dequeker, J., Dilsen, G., Falch, J. A., Felsch, B., Felsenberg, D., Finn, J. D., Gennari, C., Hoszowski, K., Jajic, I., Janott, J., Johnell, O., Kanis, J. A., Kragl, G., Lopez Vaz, A., Lorenc, R., Lyritis, G., Marchand, F., Masaryk, P., Matthis, C., Miazgowski, T., Naves-Diaz, M., Pols, H. A. P., Poor, G., Rapado, A., Raspe, H. H., Reid, D. M., Reisinger, W., Scheidt-Nave, C., Stepan, J., Todd, C., Weber, K., Woolf, A. D., and O’Neill, T. W.
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- 2002
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6. Prevalent Vertebral Deformity Predicts Incident Hip though not distal Forearm Fracture: Results from the European Prospective Osteoporosis Study
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Ismail, A. A., Cockerill, W., Cooper, C., Finn, J. D., Abendroth, K., Parisi, G., Banzer, D., Benevolenskaya, L. I., Bhalla, A. K., Bruges Armas, J., Cannata, J. B., Delmas, P. D., Dequeker, J., Dilsen, G., Eastell, R., Ershova, O., Falch, J. A., Felsch, B., Havelka, S., Hoszowski, K., Jajic, I., Kragl, U., Johnell, O., Lopez Vaz, A., Lorenc, R., Lyritis, G., Marchand, F., Masaryk, P., Matthis, C., Miazgowski, T., Pols, H. A. P., Poor, G., Rapado, A., Raspe, H. H., Reid, D. M., Reisinger, W., Janott, J., Scheidt-Nave, C., Stepan, J, Todd, C., Weber, K., Woolf, A. D., Ambrecht, G., Gowin, W., Felsenberg, D., Lunt, M., Kanis, J. A., Reeve, J., Silman, A. J., and O’Neill, T. W.
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- 2001
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7. The occurrence of ochratoxin A in kidneys of healthy pigs from Vojvodina province, Serbia
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Polovinski Horvatovic, M, primary, Radovic, I, additional, Glamocic, D, additional, Jajic, I, additional, Krstovic, S, additional, Mirkov, M, additional, and Vasiljevic, V, additional
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- 2019
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8. Phase II clinical trials with leflunomide in rheumatoid arthritis
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Mladenovic, V., Domlijan, Z., Rozman, B., Jajic, I., Mihajlovic, D., Popovic, M., Dimitrijevic, M., Zivkovic, M., Campion, G., Musikic, P., Loew-Friedrich, I., Oed, C., Seifert, H., and Strand, V.
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- 1995
9. Degenerative inter-vertebral disc disease osteochondrosis intervertebralis in Europe: Prevalence, geographic variation and radiological correlates in men and women aged 50 and over
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Armbrecht, G. Felsenberg, D. Ganswindt, M. Lunt, M. Kaptoge, S.K. Abendroth, K. Dias, A.A. Bhalla, A.K. Andia, J.C. Dequeker, J. Eastell, R. Hoszowski, K. Lyritis, G. Masaryk, P. van Meurs, J. Miazgowski, T. Nuti, R. Póor, G. Redlund-Johnell, I. Reid, D.M. Schatz, H. Todd, C.J. Woolf, A.D. Rivadeneira, F. Javaid, M.K. Cooper, C. Silman, A.J. O'Neill, T.W. Reeve, J. Banzer, D. Reisinger, W. Kragl, G. Weber, K. Scheidt-Nave, C. Delmas, P.D. Raspe, H. Johnell, O. Benevolenskaya, L.I. Aroso, A. Cannata, J. Masaryk, P. Havelka, S. Pols, H. Yershova, O. Jajic, I. the joint European Vertebral Osteoporosis Study European Prospective Osteoporosis Study Groups
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musculoskeletal diseases - Abstract
Objectives. To assess the prevalences across Europe of radiological indices of degenerative inter-vertebral disc disease (DDD); and to quantify their associations with, age, sex, physical anthropometry, areal BMD (aBMD) and change in aBMD with time. Methods. In the population-based European Prospective Osteoporosis Study, 27 age-stratified samples of men and women from across the continent aged 50+ years had standardized lateral radiographs of the lumbar and thoracic spine to evaluate the severity of DDD, using the Kellgren-Lawrence (KL) scale. Measurements of anterior, mid-body and posterior vertebral heights on all assessed vertebrae from T4 to L4 were used to generate indices of end-plate curvature. Results. Images from 10 132 participants (56% female, mean age 63.9 years) passed quality checks. Overall, 47% of men and women had DDD grade 3 or more in the lumbar spine and 36% in both thoracic and lumbar spine. Risk ratios for DDD grades 3 and 4, adjusted for age and anthropometric determinants, varied across a three-fold range between centres, yet prevalences were highly correlated in men and women. DDD was associated with flattened, non-ovoid inter-vertebral disc spaces. KL grade 4 and loss of inter-vertebral disc space were associated with higher spine aBMD. Conclusion. KL grades 3 and 4 are often used clinically to categorize radiological DDD. Highly variable European prevalences of radiologically defined DDD grades 3+ along with the large effects of age may have growing and geographically unequal health and economic impacts as the population ages. These data encourage further studies of potential genetic and environmental causes. © The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
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- 2017
10. Hip geometry, bone mineral distribution, and bone strength in European men and women: the EPOS study
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Crabtree, N, Lunt, M, Holt, G, Kroger, H, Burger, H, Grazio, S, Khaw, K.-T, Lorenc, R.S, Nijs, J, Stepan, J, Falch, J.A, Miazgowski, T, Raptou, P, Pols, H.A.P, Dequeker, J, Havelka, S, Hoszowski, K, Jajic, I, Czekalski, S, Lyritis, G, Silman, A.J, and Reeve, J
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- 2000
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11. Letter
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Reeve, J., Lunt, M., Kalender, W., Dequeker, J., Jajic, I., Lorenc, R., Pols, H., Poor, G., and Stepan, J.
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- 1996
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12. The Occurrence of Heavy Metals (Cadmium and Lead) in the Liver of Hogs in the Region of Vojvodina
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Horvatović Miroslava Polovinski, Radović Ivan, Jajić Igor, Krstović Saša, and Mirkov Mile
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cadmium ,lead ,liver ,hogs ,vojvodina ,Agriculture - Abstract
The purpose of this research is to investigate the occurrence of two heavy metals (namely cadmium (Cd) and lead (Pb)) in the liver of hogs bred in different locations in Vojvodina. A total of 30 liver samples were collected from ten pig farms in Vojvodina for experimental purposes in the period from December 2017 to January 2018. The samples collected were analysed for the presence of lead and cadmium. The average concentration of lead in all the samples was 0.39 mg/kg wet weight, whereas the samples from only one farm of the ten considered were found to contain a slightly higher average lead concentration than permitted by the Serbian standard. A lead concentration of 0.86 mg/kg wet weight was detected in one liver sample from this farm. The maximum permitted lead concentration was exceeded in the liver samples obtained from three farms. However, all the liver samples analysed were found to contain the permitted levels of cadmium, with an average cadmium concentration of 0.12 mg/kg wet weight and a maximum cadmium concentration of 0.48 mg/kg wet weight. The occurrence of heavy metals and their origin in the pig’s offals should be examined in greater detail in future research, especially because pig’s offals are used in the meat processing industry.
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- 2021
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13. Comparison of red wine, beer and vodka effects on oxydative stress and increase in arterial stiffness after normobaric oxygen breathing in healthy humans
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Modun, D, Budimir, D, Krnic, M, Gunjaca, G, Jajic, I, Vukovic, J, Kozina, B, and Boban, M.
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Red wine ,Hyperoxia ,Oxidative stress ,Arterial stiffness - Abstract
Introduction: We determined and compared acute effects of different alcoholic beverages on oxygen-induced increase in oxidative stress plasma marker and arterial stiffness in healthy humans. Materials: Ten males randomly consumed one of four tested beverages: red wine (RW), beer, vodka (0.32 g ethanol / kg body wt) and water as control. Every beverage was consumed once, a week apart, in a cross-over design. The volunteers breathed 100% normobaric O2 between 60th and 90th min of 3h study protocol. Plasma lipid hydroperoxides (LOOH) and uric acid (UA) concentration, blood alcohol concentration (BAC) and arterial stiffness (evaluated as augmentation index, AIX) were measured before and 30, 60, 90, 120 and 180 min after beverage consumption. Results: Intake of all alcoholic beverages caused a similar increase of BAC. In contrast to that, only RW caused significant increase in plasma UA (34±4 vs. 15±3, -6±2 and -8±2 μmol/L for, beer, vodka and control, respectively). Exposure to oxygen resulted in increased plasma LOOH in all groups. However, in RW group this increase was lowest (1.1±0.5) in comparison to the control (2.5±0.4), beer (1.6±0.3) and vodka (2.1±0.5 μM/L H2O2). The oxygen-induced elevation in AIX was similarly reduced in all three alcoholic beverage groups relative to the control (13.7±2.6 vs. 3.4±1.3, 0.2±1.6 and 5.4±2.2 % for red wine, beer, and vodka, respectively). Conclusion: RW provided protection against oxygen-induced oxidative stress, in contrast to beer and vodka. This beneficial effect was mainly mediated by corresponding increases in plasma UA levels. All three alcoholic beverages provided similar protection against oxygen-induced increase in arterial stiffness, probably due to central vasodilatatory effect of alcohol itself.
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- 2010
14. Association between TGF-beta and LRP 5 and 6 genetic polymorphisms with fracture risk and bone mineral density in the EPOS study
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Kaptoge, S, Scollen, S, Boonen, S, Lyritis, G, Poor, G, Nuti, R, Vaz, A, Bhalla, A, Benevolenskaya, L, Jajic, I, Todd, C, Cano, R, Khaw, K, Armas, J, Da Silva, J, Kruk, M, Lorenc, R, Dunning, A, and Reeve, J
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- 2006
15. Low BMD is less predictive than reported falls for future limb fractures in women across Europe: results from the European Prospective Osteoporosis Study
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Kaptoge, S Benevolenskaya, LI Bhalla, AK Cannata, JB and Boonen, S Falch, JA Felsenberg, D Finn, JD Nuti, R and Hoszowski, K Lorenc, R Miazgowski, T Jajic, I Lyritis, G and Masaryk, P Naves-Diaz, M Poor, G Reid, DM and Scheidt-Nave, C Stepan, JJ Todd, CJ Weber, K Woolf, AD and Roy, DK Lunt, M Pye, SR O'Neill, TW Silman, AJ and Reeve, J
- Abstract
We have previously shown that center- and sex-specific fall rates explained one-third of between-center variation in upper limb fractures across Europe. In this current analysis, our aim was to determine bow much of the between-center variation in fractures could be attributed to repeated falling, bone mineral density (BMD), and other risk factors in individuals, and to compare the relative contributions of centerspecific BMD vs. center-specific fall rates. A clinical history of fracture was assessed prospectively in 2451 men and 2919 women aged 5080 from 20 centers participating in the European Prospective Osteoporosis Study (EPOS) using standardized questionnaires (mean follow-up = 3 years). Bone mineral density (BMD, femoral neck, trochanter, and/or spine) was measured in 2103 men and 2565 women at these centers. Cox regression was used to model the risk of incident fracture as a function of the person-specific covariates: age, BMD, personal fracture history (PFH), family hip fracture history (FAMHIP), time spent walking/cycling, number of ‘all falls’ and falls not causing fracture fracture-free’) during follow-up, alcohol consumption, and body mass index. Center effects were modeled by inclusion of multiplicative gamma-distributed random effects, termed center-shared frailty (CSF), with mean 1 and finite variance theta (theta) acting on the hazard rate. The relative contributions of center-specific fall risk and center-specific BMD on the incidence of limb fractures were evaluated as components of CSF. In women, the risk of any incident nonspine fracture (n = 190) increased with age, PFH, FAMHIP, >= 1 h/day walking/cycling, and number of ‘all falls’ during follow-up (all P < 0.074). ‘Fracture-free’ falls (P = 0.726) and femoral neck BMD did not have a significant effect at the individual level, but there was a significant center-shared frailty effect (theta = 0.271, P - 0.001) that was reduced by 4% after adjusting for mean center BMD and reduced by 19% when adjusted for mean center fall rate. Femoral trochanter BMD was a significant determinant of lower limb fractures (n = 53, P = 0.014) and the center-shared frailty effect was significant for upper limb fractures (theta = 0.27 1, P = 0.011). This upper limb fracture center effect was unchanged after adjusting for mean center BMD but was reduced by 36% after adjusting for center mean fall rates. In men, risk of any nonspine fracture (n = 75) increased with PFH, fall during follow-up (P < 0.026), and with a decrease in trochanteric BMD [RR 1.38 (1.08, 1.79) per 1 SD decrease]. There was no center effect evident (theta = 0.081, P = 0.096). We conclude that BMD alone cannot be validly used to discriminate between the risk of upper limb fractures across populations without taking account of population-specific variations in fall risk and other factors. These variations might reflect shared environmental or possibly genetic factors that contribute quite substantially to the risk of upper limb fractures in women. (c) 2004 Elsevier Inc. All rights reserved.
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- 2005
16. Risk factors for Colles' fracture in men and women: results from the European Prospective Osteoporosis Study
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Reeve, J (Reeve, J), Silman, AJ (Silman, AJ), O'Neill, TW (O'Neill, TW), Finn, JD (Finn, JD), Pye, SR(Pye, SR), Cockerill, WC (Cockerill, WC), Ismail, AA (Ismail, AA), Roy, DK (Roy, DK), Banzer, D (Banzer, D), Benevolenskaya, LI (Benevolenskaya, LI), Bhalla, A (Bhalla, A), Armas, JB (Armas, JB), Cannata, JB(Cannata, JB), Delmas, P (Delmas, P), Dilsen, G (Dilsen, G), Dequeker, J (Dequeker, J), Falch, J (Falch, J), Felsch, B (Felsch, B), Felsenberg, D (Felsenberg, D), Gennari, C (Gennari, C), Hoszowski, K (Hoszowski, K), Jajic, I (Jajic, Ivo), Janot, J (Janot, J), Johnell, O (Johnell, O), Kragl, G (Kragl, G), Vaz, AL (Vaz, AL), Lorenc, R(Lorenc, R), Lyritis, G (Lyritis, G), Marchand, F (Marchand, F), Masaryk, P (Masaryk, P), Matthis, C (Matthis, C), Miazgowski, T (Miazgowski, T), Diaz, MN (Diaz, MN), Pols, HAP (Pols, HAP), Poor, G (Poor, G), Rapado, A (Rapado, A), Raspe, HH (Raspe, HH), Reid, DM (Reid, DM), Reisinger, W (Reisinger, W), Scheidt-Nave, C (Scheidt-Nave, C), Stepan, J (Stepan, J), Todd, C (Todd, C), Weber, K (Weber, K), Woolf, AD (Woolf, AD), Pye, SR (Pye, SR), Lunt, M (Lunt, M), Kanis, JA (Kanis, JA), and Cooper, C (Cooper, C)
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Risk factors for Colles' fracture in men and women: results from the European Prospective Osteoporosis Study - Abstract
Risk factors for Colles' fracture in men and women: results from the European Prospective Osteoporosis Study
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- 2004
17. Characteristics of a prevalent vertebral deformity predict subsequent vertebral fracture: results from the European Prospective Osteoporosis Study (EPOS)
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Lunt, Mark, O'Neill, Terence W., Felsenberg, Dieter, Reeve, Jonathan, Kanis, John A., Cooper, Cyrus, Silman, Alan J., Armbrecht, G., Gowin, W., Cockerill, W., Finn, J. D., Pye, S., Matthis, C., Raspe, H. H., Banzer, D., Benevolenskaya, L. I., Bhalla, A., Cannata, J. B., Dequeker, J., Eastell, R., Felsch, B., Franke, J., Gennari, C., Havelka, S., Hoszowski, K., Jajic, I., Janott, J., Johnell, O., Lopes Vaz, A., Lorenc, R., Lyritis, G., Masaryk, P., Miazgowski, T., Pols, H. A P, Poor, G., Reid, D. M., Reisinger, W., Scheidt-Nave, C., Stepan, J. J., Todd, C. J., Weber, K., and Woolf, A. D.
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Male ,medicine.medical_specialty ,Histology ,Physiology ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,Population ,Dentistry ,Vertebral deformity ,Models, Biological ,Sex Factors ,Risk Factors ,Deformity ,Medicine ,Humans ,Prospective Studies ,Prospective study ,Risk factor ,education ,Prospective cohort study ,Aged ,education.field_of_study ,business.industry ,Age Factors ,Middle Aged ,medicine.disease ,Incident vertebral fracture ,Confidence interval ,Surgery ,Vertebra ,Europe ,medicine.anatomical_structure ,Relative risk ,Spinal Fractures ,Female ,medicine.symptom ,Prediction ,business ,Population study - Abstract
The presence of a prevalent vertebral deformity increases the risk of a future vertebral fracture. The aim of this study was to determine whether certain characteristics of the prevalent deformity, including its shape and location in the spine, influenced this effect. The 3100 men and 3500 women who took part in this analysis were recruited from population registers for participation in the European Prospective Osteoporosis Study (EPOS). Subjects had lateral thoracic and lumbar spine x-rays at baseline, and again after a mean interval of 3.8 years. Prevalent morphometric vertebral deformities on the baseline film were identified by the McCloskey-Kanis method. Incident fractures were defined as vertebrae that also satisfied the McCloskey-Kanis criterion for prevalent deformities on the follow-up film, and in addition had at least one height (anterior, mid, or posterior) which had reduced by at least 20% between films. Poisson regression was used to assess the association between various characteristics of the prevalent deformity and the risk of an incident vertebral fracture, with generalised estimating equations used to allow for the fact that each subject contributed several vertebrae to the analysis. The risk of an incident fracture increased with the number of prevalent deformities: relative risk (RR) for one prevalent deformity 3.2 (95% confidence interval (CI); 2.1, 4.8); 9.8 (95% CI;6.1, 15.8) for 2; and 23.3 (95% CI;15.3, 35.4) for 3 or more. Relative risks differed significantly according to the shape of the prevalent deformity, ranging from 5.9 (95% CI; 4.1, 8.6) if the anterior and mid heights were reduced to 1.6 (95% CI;0.8, 3.2) if the posterior and mid heights were reduced. Risks varied also according to the severity of the deformity. There were fivefold differences in relative risk of incident fracture depending on the location of the prevalent deformity within the spine. Compared to vertebrae in subjects with no deformities at baseline, the relative risk of an incident fracture within three vertebrae of a prevalent deformity was greater (7.7 (95% CI;5.6, 10.5)) than the risk in more distant vertebrae (4.0 (95% CI;2.6, 6.0)). In summary, the risk of a subsequent vertebral fracture in individuals with preexisting deformities is importantly influenced by the characteristics of these deformities. © 2003 Elsevier Inc. All rights reserved.
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- 2003
18. Determinants of incident vertebral fracture in men and women: Results from the European Prospective Osteoporosis Study (EPOS)
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Roy, D.K. O'Neill, T.W. Finn, J.D. Lunt, M. Silman, A.J. Felsenberg, D. Armbrecht, G. Banzer, D. Benevolenskaya, L.I. Bhalla, A. Armas, J.B. Cannata, J.B. Cooper, C. Dequeker, J. Diaz, M.N. Eastell, R. Yershova, O.B. Felsch, B. Gowin, W. Havelka, S. Hoszowski, K. Ismail, A.A. Jajic, I. Janott, I. Johnell, O. Kanis, J.A. Kragl, G. Vaz, A.L. Lorenc, R. Lyritis, G. Masaryk, P. Matthis, C. Miazgowski, T. Gennari, C. Pols, H.A.P. Poor, G. Raspe, H.H. Reid, D.M. Reisinger, W. Scheidt-Nave, C. Stepan, J.J. Todd, C.J. Weber, K. Woolf, A.D. Reeve, J.
- Abstract
The aim of this analysis was to determine the influence of lifestyle, anthropometric and reproductive factors on the subsequent risk of incident vertebral fracture in men and women aged 50-79 years. Subjects were recruited from population registers from 28 centers across Europe. At baseline, they completed an interviewer-administered questionnaire and had lateral thoraco-lumbar spine radiographs performed. Repeat spinal radiographs were performed a mean of 3.8 years later. Incident vertebral fractures were defined morphometrically and also qualitatively by an experienced radiologist. Poisson regression was used to determine the influence of the baseline risk factor variables on the occurrence of incident vertebral fracture. A total of 3173 men (mean age 63.1 years) and 3402 women (mean age 62.2 years) contributed data to the analysis. In total there were 193 incident morphometric and 224 qualitative fractures. In women, an age at menarche 16 years or older was associated with an increased risk of vertebral fracture (RR = 1.80; 95%CI 1.24, 2.63), whilst use of hormonal replacement was protective (RR=0.58; 95%CI 0.34, 0.99). None of the lifestyle factors studied including smoking, alcohol intake, physical activity or milk consumption showed any consistent associations with incident vertebral fracture. In men and women, increasing body weight and body mass index were associated with a reduced risk of vertebral fracture though, apart from body mass index in men, the confidence intervals embraced unity. For most variables the strengths of the associations observed were similar using the qualitative and morphometric approaches to fracture definition. In conclusion our data suggest that modification of other lifestyle risk factors is unlikely to have a major impact on the population occurrence of vertebral fractures. The important biological mechanisms underlying vertebral fracture risk need to be explored using new investigational strategies.
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- 2003
19. Incidence of limb fracture across Europe: Results from the European Prospective Osteoporosis Study (EPOS)
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Ismail, AA Pye, SR Cockerill, WC Lunt, M Silman, AJ and Reeve, J Banzer, D Benevolenskaya, LI Bhalla, A Armas, JB Cannata, JB Cooper, C Delmas, PD Dequeker, J and Dilsen, G Falch, JA Felsch, B Felsenberg, D Finn, JD and Gennari, C Hoszowski, K Jajic, I Janott, J Johnell, O and Kanis, JA Kragl, G Vaz, AL Lorenc, R Lyritis, G and Marchand, F Masaryk, P Matthis, C Miazgowski, T and Naves-Diaz, M Pols, HAP Poor, G Rapado, A Raspe, HH and Reid, DM Reisinger, W Scheidt-Nave, C Stepan, J Todd, C and Weber, K Woolf, AD O'Neill, TW
- Abstract
The aim of this population-based prospective study was to determine the incidence of limb fracture by site and gender in different regions of Europe. Men and women aged 50-79 years were recruited from population registers in 31 European centers. Subjects were invited to attend for an interviewer-administered questionnaire and lateral spinal radiographs. Subjects were subsequently followed up using an annual postal questionnaire which included questions concerning the occurrence of new fractures. Self-reported fractures were confirmed where possible by radiograph, attending physician or subject interview. There were 6451 men and 6936 women followed for a median of 3.0 years. During this time there were 140 incident limb fractures in men and 391 in women. The age-adjusted incidence of any limb fracture was 7,3/1000 person-years [pyrs] in men and 19 per 1000 pyrs in women, equivalent to a 2,5 times excess in women. Among women, the incidence of hip, humerus and distal forearm fracture, though not ‘other’ limb fracture, increased with age, while in men only the incidence of hip and humerus fracture increased with age. Among women, there was evidence of significant variation in the occurrence of hip, distal forearm and humerus fractures across Europe, with incidence rates higher in Scandinavia than in other European regions. though for distal forearm fracture the incidence in east Europe was similar to that observed in Scandinavia. Among men, there was no evidence of significant geographic variation in the occurrence of these fractures. This is the first large population-based study to characterize the incidence of limb fracture in men and women over 50 years of age across Europe. There are substantial differences in the descriptive epidemiology of limb fracture by region and gender.
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- 2002
20. Fatty and amino acid profile of mealworm larvae (Tenebrio molitor L.)
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Jajić Igor, Popović Aleksandra, Urošević Miroslav I., Krstović Saša, Petrović Miloš, Guljaš Darko, and Samardžić Miljan
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edible insects ,tenebrionidae ,chemical composition ,Animal culture ,SF1-1100 - Abstract
The yellow mealworm (Tenebrio molitor L., Coleoptera: Tenebrionidae) is an edible insect, distributed worldwide and a convenient candidate for industrial-scale production. Mealworms could be commercially used for the substitution of conventional protein sources. In our previous study, it was found that T. molitor larvae predominantly contained crude protein (55.83%) and crude fat (25.19%), as well as low content of nitrogen-free extract (based on dry weight). Mealworm specimens were maintained in an incubator under controlled conditions in plastic containers. Insects were sieved and put into the container with boiling water and cooked for 180 seconds. Moisture content was determined as weight loss after drying of larvae. Amino acids were determined on an Agilent Technologies 1260 series HPLC system. Fatty acid composition was determined on a Thermo Scientific TRACE 1300 gas chromatograph equipped with a flame ionization detector using TR-FAME column. The results showed that the content of unsaturated fatty acid is very high, i.e. oleic acid (C18:1) formed the major lipid component in 40.83%, which was followed by linoleic acid (C18:2, omega-6 fatty acid) with 29.80% and linolenic acid (C18:3) with 1.08%. The essential amino acids are highly represented in the samples (in % dry matter). This primarily refers to isoleucine (4.12), tyrosine (3.86), phenylalanine (3.06), leucine (2.96), lysine (2.67) and methionine (1.76). The differences in essential fatty and amino acid content between our results and discussed literature data, could be the consequence of different substrates used for rearing of insects. After everything stated above, the biological value of T. molitor larvae proves that it could be suitable as animal feed.
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- 2020
21. Does location of vertebral deformity within the spine influence back pain and disability?
- Author
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Cockerill, W., Ismail, A. A., Cooper, C., Matthis, C., Raspe, H., Silman, A. J., O'Neill, T. W., Agnusdei, D., Bergmann, K., Dequeker, J., Felsenberg, D., Kanis, J. A., Kruskemper, G., Weiland, E., Kaldis, L., Mews, J., Finn, D., Lauermann, T., Weber, K., Geusens, P., Jajic, I., Havelka, S., Vavrincova, P., Letkovska, A., Masaryk, P., Delmas, P. D., Marchand, F., Banzer, D., Kirschner, S., Reisinger, W., Janott, J., Schatz, H., Franke, J., Scheidt-Nave, C., Zeigler, R., Abendroth, K., Felsch, B., Antoniou, A., Lyritis, G., Kiss, C., Poor, G., Gennari, C., Ortolani, S., Hofman, A., Pols, H. A P, Falch, J. A., Meyer, H. E., Czekalski, S., Miazgowski, T., Hoszowski, K., Lorenc, R. S., Aroso, A., Lopez Vaz, A., Benevolenskaya, L. I., Mikhailov, E. E., Roig Escofet, D., Ruiz Martin, M., Sosa, M., Diaz Curiel, M., Rapado, A., Cannata Andia, J. B., Diaz Lopez, J. B., Johnell, O., Nilsson, B., Dilsen, G., Reid, D. M., Bhalla, A. K., Ring, F., Todd, C., Williams, R., Reeve, J., Eastell, R., and Woolf, A. D.
- Subjects
Male ,medicine.medical_specialty ,vertebral deformity, back pain ,Population ,Immunology ,Lumbar vertebrae ,General Biochemistry, Genetics and Molecular Biology ,Thoracic Vertebrae ,Lumbar ,Sex Factors ,Rheumatology ,medicine ,Deformity ,Back pain ,Immunology and Allergy ,Humans ,Functional ability ,education ,Aged ,education.field_of_study ,Lumbar Vertebrae ,business.industry ,Middle Aged ,Low back pain ,Extended Report ,medicine.anatomical_structure ,Back Pain ,Thoracic vertebrae ,Physical therapy ,Osteoporosis ,Female ,Spinal Diseases ,medicine.symptom ,business - Abstract
Objective - Vertebral deformity is associated with back pain and disability. The aim of tiffs analysis was to determine whether location within the spine influences the strength of association between vertebral deformity, back pain and disability. Methods - Men and women aged 50 years and over were recruited from population registers in 30 European centres. Subjects were invited for an interviewer administered questionnaire, and for lateral spinal radiographs. The questionnaire included questions about back pain, general health and functional ability. The spinal radiographs were evaluated morphometrically and vertebral deformity defined according to the McGloskey-Kanis method. Results - 756 (11.7%) men and 885 (11.8%) women had evidence of one or more vertebral deformities. Among women with a single deformity, after adjusting for age and centre, those with a lumbar deformity were more likely than those with a thoracic deformity to report back pain, both currently (OR = 1.4; 95% CI 1.0, 2.0) and in the past year (OR = 1.5; 95% CI 1.0, 2.3). No association was observed in men. Among women with two deformities, those with adjacent deformities were more likely than those with non-adjacent deformities to report poor general health (OR = 2.2; 95%CI 0.9, 5.6), impaired functional ability (OR = 1.9; 95%CI 0.8, 4.7) and current back pain (OR = 2.1; 95%CI 0.9, 4.9), though none of these associations were statistically significant. By contrast, among men, non-adjacent deformities were associated with impaired functional ability compared with those with adjacent deformities. Conclusions - Location within the spine influences the strength of association between self reported health factors and vertebral deformity.
- Published
- 2000
22. Validity of self-report of fractures: Results from a prospective study in men and women across Europe
- Author
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Ismail, A. A., O'Neill, T. W., Cockerill, W., Finn, J. D., Johnell, O., Matthis, C., Raspe, A., Reeve, J., Silman, Alan J., Weber, K., Dequeker, J., Jajic, I., Havelka, S., Stephan, J., Masaryk, P., Delmas, P. D., Marchand, F., Felsenberg, D., Banzer, D., Reisinger, W., Schatz, H., Kragl, G., Scheidt-Nave, C., Abendroth, K., Felsch, B., Raspe, H., Lyritis, G., Dretakis, E., Poor, G., Gennari, C., Lips, P., Pols, H. A P, Falch, J. A., Miazgowski, T., Hoszowski, K., Lorenc, R., Bruges Armas, J., Lopez Vaz, A., Benevolenskaya, L. I., Ershova, O., Rapado, A., Perez Cano, R., Galan Galan, F., Cannata, J. B., Kröger, H., Dilsen, G., Reid, D. M., Bhalla, A. K., Woolf, A. D., and Todd, Chris
- Subjects
Medicine(all) ,education.field_of_study ,medicine.medical_specialty ,business.industry ,Questionnaire ,Endocrinology, Diabetes and Metabolism ,Incidence (epidemiology) ,Medical record ,Osteoporosis ,Population ,Poison control ,medicine.disease ,Manikin ,Fracture ,Orthopedic surgery ,Validation ,medicine ,False positive paradox ,Physical therapy ,Prospective cohort study ,education ,business - Abstract
In population-based studies of osteoporosis, ascertainment of fractures is typically based on self-report, with subsequent verification by medical records. The aim of this analysis was to assess the validity of self-report of incident nonspine fractures using a postal questionnaire. The degree of overreporting of fracture (false positives) was assessed by comparing self-reports of new fracture from respondents in the multicenter European Prospective Osteoporosis Study with data from other sources including radiographs and medical records. In the analysis, 563 subjects reported nonspine fractures. Verification of the presence of fracture was possible in 510 subjects. Of these, fractures were not confirmed in 11% (false positives). The percentage of false positives was greater in men than in women (15% vs 9%, p = 0.04), and less for fractures of the distal forearm and hip than for fractures at other sites. In a separate study, the degree of underreporting (false negatives) was assessed by follow-up of 251 individuals with confirmed fracture ascertained from the records of fracture clinics in three European centers (Lubeck, Oviedo, Warsaw), Questionnaire responses were received from 174 (69%) subjects. Of these, 12 (7%) did not recall sustaining a fracture (false negatives). The percentage of false negatives was lower for hip and distal forearm fractures with only 3 of 90 (3%) such fractures not recalled. Using the combined data from both studies, of those who reported a 'date' of fracture on the questionnaire, 91% of subjects were correct to within 1 month of the actual date of the fracture. A postal questionnaire is a relatively simple and accurate method for obtaining information about the occurrence of hip and distal forearm fractures, including their timing. Accuracy of ascertainment of fractures at other sites is less good and where possible self-reported fractures at such sites should be verified from other sources.
- Published
- 2000
23. Hip geometry, bone mineral distribution, and bone strength in European men and women: the EPOS Study
- Author
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Crabtree, N Lunt, M Holt, G Kroger, H Burger, H and Grazio, S Khaw, KT Lorenc, RS Nijs, J Stepan, J and Falch, JA Miazgowski, T Raptou, P Pols, HAP Dequeker, J and Havelka, S Hoszowski, K Jajic, I Czekalski, S and Lyritis, G Silman, AJ Reeve, J
- Abstract
Hip geometry and bone mineral density (BMD) have been shown previously to relate, independently of each other, to risk of hip fracture. We used Lunar DPX “beta” versions of hip strength analysis (HSA) and hip axis length (HAL) software to analyze scans from ten representative age-stratified population samples in the European Prospective Osteoporosis Study (EPOS), All 1617 subjects were >50 years of age, and 1033 were women. The data were modeled with gender and center as categorical variables. The bone mineral density of the upper half of the femoral neck declined at a faster rate with age than that in the lower half, Femoral neck cross-sectional moment of inertia (CSMI), a measure of resistance to bending, showed no significant age reduction in either gender. However,height and weight effects on CSMI were significantly more beneficial in men than in women (0.002 < p < 0.012) and the weight effect appeared to be mediated by bone mineral content (BMC), Compressive stress (Cstress), defined as the stress in the femoral neck at its weakest cross section arising from a standardized fall, was higher in women. Although Cstress increased with body weight when BMC was held constant, in practice it fell through the association and statistical interaction of rising body weight with rising BMC, HAL, as expected, was strongly positively associated with male gender and also height (p < 0.0001). Hip strength-related indices were markedly center-dependent. Significant differences (p < 0.0001) were noted between the centers for all the variables investigated that related to hip geometry. Adjustment for femoral neck bone mineral content (totBMC) showed these center differences to account for >50% of center variation in hip strength, which remained highly significant (p < 0.0001). We conclude that there are substantial geographical differences in femoral neck geometry as well as in BMD, These geometric variations may contribute to the large variations in hip fracture risk across Europe. The effects of aging on hip strength need to be explored in longitudinal studies. (Bone 27:151-159; 2000) (C) 2000 by Elsevier Science Inc. All rights reserved.
- Published
- 2000
24. Number and type of vertebral deformities: Epidemiological characteristics and relation to back pain and height loss
- Author
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Ismail, A. A., Cooper, C., Felsenberg, D., Varlow, J., Kanis, J. A., Silman, A. J., O'Neill, T. W., Agnusdei, D., Bergmann, K., Dequeker, J., Kruskemper, G., Raspe, H., Weiland, E., Kaldis, L., Finn, D., Cockerill, W., Lauermann, T., Weber, K., Geusens, P., Jajic, I., Havelka, S., Letkovska, A., Masaryk, P., Delmas, P. D., Marchand, F., Banzer, D., Kirschner, S., Reisinger, W., Janott, J., Schatz, H., Franke, J., Scheidt-Nave, C., Zeigler, R., Abendroth, K., Felsch, B., Matthis, C., Antoniou, A., Lyritis, G., Kiss, C., Poor, G., Gennari, C., Ortolani, S., Hofman, A., Falch, J. A., Meyer, H. E., Czekalski, S., Miazgowski, T., Hoszowski, K., Lorenc, R. S., Aroso, A., Lopez, A., Benevolenskaya, L. I., Mikhailov, E. E., Escofet, D. Roig, Martin, M. Ruiz, Sosa, M., Curiel, M. Diaz, Rapado, A., Andia, J. B Cannata, Lopez, J. B Diaz, Johnell, O., Nilsson, B., Dilsen, G., Reid, D. M., Bhalla, A. K., Ring, F., Todd, C., Williams, R., Reeve, J., Eastell, R., and Woolf, A. D.
- Subjects
medicine.medical_specialty ,Epidemiology ,Endocrinology, Diabetes and Metabolism ,Population ,Osteoporosis ,Vertebral osteoporosis ,Vertebral deformity ,Lumbar ,stomatognathic system ,Back pain ,medicine ,Deformity ,education ,Orthodontics ,Medicine(all) ,education.field_of_study ,business.industry ,technology, industry, and agriculture ,medicine.disease ,Low back pain ,Vertebra ,Surgery ,medicine.anatomical_structure ,Orthopedic surgery ,medicine.symptom ,business - Abstract
Vertebral deformity is the classical hallmark of osteoporosis. Three types of vertebral deformity are usually described: crush, wedge and biconcave deformities. However, there are few data concerning the descriptive epidemiology of the individual deformity types, and differences in their underlying pathogenesis and clinical impact remain uncertain. The aim of this study was to compare the epidemiological characteristics of the three types of vertebral deformity and to explore the relationships of the number and type of deformity with back pain and height loss. Age-stratified random samples of men and women aged 50 years and over were recruited from population registers in 30 European centers (EVOS study). Subjects were invited to attend for an interviewer-administered questionnaire and lateral spinal radiographs. The presence, type and number of vertebral deformities was determined using the McCloskey-Kanis algorithm. A total of 13,562 men and women were studied; mean age in men was 64.4 years (SD 8.5), and in women 63.8 years (SD 8.5 years). There was evidence of variation in the occurrence of wedge, crush and biconcave deformity by age, sex and vertebral level. Wedge deformities were the most frequent deformity and tended to cluster at the mid-thoracic and thoracolumbar regions of the spine in both men and women. Similar predilection for these sites was observed for crush and to a lesser extent biconcave deformities though this was much less marked than for wedge deformities. In both sexes the frequency of biconcave deformities was higher in the lumbar than the thoracic spine and unlike the other deformity types it did not decline in frequency at lower lumbar vertebral levels. The prevalence of all three types of vertebral deformity increased with age and was more marked in women. There were no important differences in the effect of age on the different deformity types. All types of deformity were associated with height loss, which was greatest for individuals with crush deformity. Back pain was also associated with all types of deformity. Overall, these results do not suggest important differences in pathophysiology between the three deformity types. Biomechanical factors appear to be important in determining their distribution within the spine. All deformity types are linked with adverse outcomes, though crush deformities showed greater height loss than the other deformity types.
- Published
- 1999
25. Anthropometric measurements and vertebral deformities
- Author
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Johnell, O., Oneill, T., Felsenberg, D., Kanis, J., Cooper, C., Silman, A. J., Abendroth, K., Agnusdei, D., Antoniou, A., Aroso, A., Banzer, D., Benevolenskaya, L. I., Bergmann, K., Bhalla, A. K., Andia, J. B. C., Czekalski, S., Delmas, P. D., Dequeker, J., Curiel, M. D., Lopez, J. D. D., Dilsen, G., Eastell, R., Falch, J. A., Felsch, B., Franke, J., Gennari, C., Geusens, P., Havelka, S., Hofman, A., Hoszowski, K., Jajic, I., Janott, J., Kalidis, L., Kirschner, S., Kiss, C., Kruskemper, G., Lauermann, T., Letkovska, A., Vaz, A. L., Lorenc, R. S., Lyritis, G., Marchand, F., Marsden, D., Masaryk, P., Matthis, C., Mews, J., Meyer, H. E., Tomasz Miazgowski, Mikhailov, E. E., Nilsson, B., Ortolani, S., Petta, G., Pols, H. A. P., Poor, G., Rapado, A., Raptou, P., Raspe, H., Reeve, J., Reid, D. M., Reisinger, W., Ring, F., Escofet, D. R., Martin, M. R., Schatz, H., Scheidtnave, C., Sosa, M., Todd, C., Varincova, P., Varlow, J., Weber, K., Wieland, E., Williams, R., Woolf, A. D., and Ziegler, R.
- Subjects
stomatognathic system ,Anthropometric measurements and vertebral deformities ,technology, industry, and agriculture - Abstract
Anthropometric measurements and vertebral deformities
- Published
- 1997
26. The Prevalence of Vertebral Deformity in European Men and Women: The European Vertebral Osteoporosis Study
- Author
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Oneill, Tw, Felsenberg, D., Varlow, J., Cooper, C., Kanis, Ja, Silman, Aj, Agnusdei, D., Bergmann, K., Dequeker, J., Kruskemper, G., Raspe, H., Marsden, D., Wieland, E., Kalidis, L., Mews, J., Lauermann, T., Weber, K., Geusens, P., Jajic, I., Havelka, S., Vavrincova, P., Delmas, Pd, Marchand, F., Banzer, D., Kirschner, S., Reisinger, W., Janott, J., Schatz, H., Franke, J., Scheidtnave, C., Ziegler, R., Abendroth, K., Felsch, B., Matthis, C., Antoniou, A., Lyritis, G., Kiss, C., Poor, G., Gennari, C., Ortolani, S., Hofman, A., Pols, Hap, Falch, Ja, Meyer, He, Czekalski, S., Tomasz Miazgowski, Hoszowski, K., Lorenc, Rs, Aroso, A., Vaz, Al, Benevolenskaya, Li, Mikhailov, Ee, Letkovska, A., Masaryk, P., Escofet, Dr, Martin, MR, Sosa, M., Curiel, Md, Rapado, A., Andia, Jbc, Lopez, Jbd, Johnell, O., Nilsson, B., Dilsen, G., Reid, Dm, Bhalla, Ak, Ring, F., Todd, C., Williams, R., Reeve, J., Eastell, R., and Woolf, Ad
- Subjects
stomatognathic system ,technology, industry, and agriculture ,The Prevalence of Vertebral Deformity in European Men and Women: The European Vertebral Osteoporosis Study - Abstract
The Prevalence of Vertebral Deformity in European Men and Women: The European Vertebral Osteoporosis Study
- Published
- 1996
27. Egg quality of Japanese quail in Serbia (Coturnix coturnix japonica)
- Author
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Djukic-Stojcic, Mirjana, primary, Milosevic, N., additional, Peric, L., additional, Jajic, I., additional, and Tolimir, N., additional
- Published
- 2012
- Full Text
- View/download PDF
28. Research on reproductive performance of mares in Serbia using bacteriological examination
- Author
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Urosevic, M.I., primary, Stojanovic, D., additional, Lako, B., additional, Jajic, I., additional, Milicic, Z., additional, Pusic, I., additional, and Prodanov-Radulovic, J., additional
- Published
- 2011
- Full Text
- View/download PDF
29. Chemical Composition of Mealworm Larvae (Tenebrio molitor) Reared in Serbia
- Author
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Jajić Igor, Popović Aleksandra, Urošević Miroslav, Krstović Saša, Petrović Miloš, and Guljaš Darko
- Subjects
chemical composition ,larvae ,serbia ,tenebrio molitor ,Agriculture - Abstract
The use of insects as “novel” and natural feed materials seems to be an attractive alternative protein source for poultry, pigs and fish since more than 80% of their chemical composition (dry weight basis) is crude protein and crude fat content. Therefore, the aim of this study was to determine some chemical composition parameters of powdered mealworm larvae, as a potential animal feed as well as human novel food. It was found that the crude protein (55.83%) and crude fat (25.19%) content was predominant, as well as that the content of nitrogen-free extract was low. Coincided with the high protein content, the levels of the most important amino acids were found to be considerable, especially lysine (3.18%) and threonine (1.34%). Crude fibre content was 7.15%, while ash was 4.84%. The samples were found to be rich in most nutritive elements, especially phosphorus (1.06%) and potassium (1.12%) in terms of macroelements, and zinc (138.2 mg/kg) in terms of microelements. Based on our research and other experimental results, it can be concluded that meals from the insects originating from the order Coleoptera, Tenebrionidae (mealworms) may be successfully used as feed material in diets of livestock animals, especially poultry.
- Published
- 2019
- Full Text
- View/download PDF
30. Occurrence of aflatoxin B1, ochratoxin A and zearalenone in maize silage in the region of Vojvodina, Serbia
- Author
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Glamočić Dragan, Polovinski Horvatović Miroslava, Jajić Igor, Krstović Saša, and Guljaš Darko
- Subjects
vojvodina ,maize silage ,aflatoxin b1 ,ochratoxin a ,zearalenone ,Veterinary medicine ,SF600-1100 - Abstract
Silage made from the whole-plant maize is one of the most popular forages in Serbia. Consumption of maize silage by cows can be up to 30-35 kg/day. In Serbia in the few last years in the focus of the public and agriculture community were two mycotoxins, aflatoxin B1 and its metabolite aflatoxin M1 due to the outbreak of contaminated maize which affected the Balkans in 2012. Maize is regularly checked on the occurrence of aflatoxin B1, however forages are often neglected as a potential source of mycotoxins in the nutrition of dairy cattle.
- Published
- 2019
- Full Text
- View/download PDF
31. THE SPECTRUM OF DERMATOLOGICAL SYMPTOMS OF PACHYDERMOPERIOSTOSIS (PRIMARY HYPERTROPHIC OSTEOARTHROPATHY). A GENETIC, CYTOGENETIC AND ULTRASTRUCTURAL STUDY
- Author
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Matucci-Cerinic M, Lotti T, stefano calvieri, Ghersetich I, Sacerdoti L, Teofoli P, Jajic I, and Cagnoni M
- Subjects
Adult ,Male ,Microscopy, Electron ,Osteoarthropathy, Primary Hypertrophic ,pachydermoperiostosis ,endothelial cells ,fibroblasts ,ultrastructure ,Humans ,Middle Aged ,Skin Diseases ,Chromosome Banding - Abstract
Pachydermoperiostosis (PDP) is characterized by finger clubbing, periostosis and peculiar skin involvement (pachydermia, seborrhea and folliculitis). The aim of our work was to determine the occurrence of dermatological symptoms in patients with PDP and their relatives, and to study ultrastructural skin changes in the complete and incomplete forms of the disease. A genetic and cytogenetic study was performed in order to identify the mechanism of transmission, to discover possible links to other genetic and non-genetic diseases and to determine the chromosomal complement and eventual chromosomal anomalies. Pachydermia was the most frequent skin alteration together with seborrhea ; folliculitis was present in five patients. In the relatives mild pachydermia was detected in 2 out of 26, while seborrhea was present in 6 subjects. Light microscopic observation showed acanthotic epidermis and endothelial hyperplasia in the dermis with partial occlusion of the lumen, lymphohistiocytic infiltrate, and thickening and packing of collagen fibers. Electron microscopy showed fibroblast activation with increased fibrillogenic activity as shown by hypertrophic Golgi complexes and rough endoplasmatic reticulum with cisternae filled with microfibrils. Endothelial cells partially or completely occluded the capillary lumen and presented an increased amount of Weibel Palade bodies. These data show that skin involvement in PDP is a prominent feature, that sometimes these symptoms may also be present in their relatives, and that endothelial and fibroblast activation is present in the skin. Unfortunately the cytogenetic study did not provide any information about possible karyotype abnormalities.
- Published
- 1992
32. Aflatoxin M1 Transfer Rate from Milk into Cheese and Whey During the Production of Hard Cheese
- Author
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Krstović Saša, Vranješ Anka Popović, Kasalica Anka, Jevtić Marija, and Jajić Igor
- Subjects
aflatoxin m1 ,transfer ,milk ,hard cheese ,whey ,hplc-fld ,Agriculture - Abstract
The aim of this study was to investigate aflatoxin M1 (AFM1) transfer from naturally contaminated raw milk into cheese and whey, during the production of Livanjski cheese (hard cheese type). Raw milk samples were collected from 4 farms in Serbia. The samples were then tested for AFM1 content and were later used for hard cheese production. Four cheese samples were produced, and the matching whey samples were also collected. The milk samples included two samples containing AFM1 above the EU maximum level (0.077±0.009 and 0.118±0.008 µg/kg) and the other two samples below the maximum level of 0.05 µg/kg (0.021±0.002 and 0.034±0.004 µg/kg). Regarding AFM1 transfer into cheese from the milk samples containing AFM1 above the EU maximum level, the rate was approximately 4-fold (383% and 410%). On the other hand, in the cheese samples made from milk containing AFM1 below the EU maximum level, almost 10-fold levels of AFM1 content in milk were found (transfer rates of 934% and 961%). As for the whey samples, AFM1 levels were below the levels found in the milk samples (transfer rates of 78%, 74%, 68% and 57%). The difference in the transfer rates for the cheese made from the milk samples contaminated at different levels may indicate the possibility that the AFM1 transfer rate from milk into cheese depends on the content of this toxin in milk.
- Published
- 2018
- Full Text
- View/download PDF
33. Low BMD is less predictive than reported falls for future limb fractures in women across Europe: results from the European Prospective Osteoporosis Study
- Author
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Kaptoge, S., primary, Benevolenskaya, L.I., additional, Bhalla, A.K., additional, Cannata, J.B., additional, Boonen, S., additional, Falch, J.A., additional, Felsenberg, D., additional, Finn, J.D., additional, Nuti, R., additional, Hoszowski, K., additional, Lorenc, R., additional, Miazgowski, T., additional, Jajic, I., additional, Lyritis, G., additional, Masaryk, P., additional, Naves-Diaz, M., additional, Poor, G., additional, Reid, D.M., additional, Scheidt-Nave, C., additional, Stepan, J.J., additional, Todd, C.J., additional, Weber, K., additional, Woolf, A.D., additional, Roy, D.K., additional, Lunt, M., additional, Pye, S.R., additional, O'Neill, T.W., additional, Silman, A.J., additional, and Reeve, J., additional
- Published
- 2005
- Full Text
- View/download PDF
34. AB0216 Transformation of primary hypertrophic osteoarthropathy into secondary caused by bronchogenic carcionoma
- Author
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Jajic, Z, primary and Jajic, I, additional
- Published
- 2001
- Full Text
- View/download PDF
35. AB0133 Blue coloured skin in psoriatic arthritis
- Author
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Jajic, I, primary, Jajiæ, Z, additional, and Nemcic, T, additional
- Published
- 2001
- Full Text
- View/download PDF
36. RADIOLOGICAL CHANGES OF THE SYMPHYSIS IN ANKYLOSING SPONDYLITIS
- Author
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Jajic, Z., primary, Jajic, I., additional, and Grazio, S., additional
- Published
- 2000
- Full Text
- View/download PDF
37. Radiological changes of short and flat bones in primary hypertrophic osteoarthropathy
- Author
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JAJIC, Z., primary and JAJIC, I., additional
- Published
- 1998
- Full Text
- View/download PDF
38. Environmental assessment of the greenhouse gases emission from poultry production in Russia's central region
- Author
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Samardžić Miljan M., Vasin Jovica R., Jajić Igor M., Andreeva Irina V., Latković Dragana S., and Vasenev Ivan I.
- Subjects
environmental assessment ,greenhouse gases ,poultry ,manure ,energy ,fertilisers ,agro-ecosystems ,carbon footprint ,Agriculture - Abstract
With an estimated rise in poultry production and consumption of chicken meat in Russia by 9% up to 2022, as well as development of self-sustainable poultry production, the need has arisen for environmental assessment of this production, and within it especially greenhouse gases (GHGs) emission assessment. The goal of this work is to show a calculation procedure for obtaining estimations for the carbon footprint of the 1 kg of live chicken at the farm gate, taking into account regional typological features of agricultural production in agro-ecosystems. The methodology of carbon footprint (CF) calculation is based on the life cycle assessment (LCA) methodology, and on IAGRICO2 calculator, developed for agriculture products. Results have shown that in modern technology of poultry farming, 5.79 kg CO2 e was emitted on average per kg of body mass, and that about 47% of emission was from manure, around 27.5% from crop production (fuel and fertiliser) and 25.5% from fuel and energy needed for heating, sanitation and feeding of chickens. The main distinction of Central Russia is low efficiency of the fertiliser application on crop fields and manure management, storage and utilisation, which has as a result high emissions of the nitrous oxide. This is the field where the implementation of the intensive technologies of precise farming, manure handling, utilisation and management will significantly decrease GHG emission, with preserving yield of crops and quantity and quality of chicken meat.
- Published
- 2018
39. Gynaecological and Reproductive Risk Factors of Vertebral Osteoporosis
- Author
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Jajic, I., primary, Grazio, S., additional, and Jajic, Z., additional
- Published
- 1996
- Full Text
- View/download PDF
40. Femoral head osteonecrosis in primary hypertrophic osteoarthropathy.
- Author
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Jajic, I, primary
- Published
- 1993
- Full Text
- View/download PDF
41. Fumonisins production potential of Fusarium verticillioides isolated from Serbian maize and wheat kernels
- Author
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Krstović Saša Z., Jakšić Sandra M., Bočarov-Stančić Aleksandra S., Stanković Slavica S., Janković Snežana M., and Jajić Igor M.
- Subjects
fumonisin ,Fusarium verticillioides ,cereals ,toxigenic potential ,Science (General) ,Q1-390 - Abstract
The production of fumonisins by potentially toxigenic Fusarium verticillioides isolates originating from Serbian maize and wheat kernels was tested in vitro. A total of six F. verticillioides isolates were incubated on yeast extract sucrose medium (YESA) for 4 weeks at 25 °C in the dark. Their toxin production potential was tested by applying a modified HPLC method for determination of fumonisins in cereals, since the TLC method gave no results. Analyses were performed on a HPLC-FLD system after sample extraction from YESA and extract cleanup on a SPE column. Although the isolates were tested for fumonisin B1, B2 and B3, only fumonisin B1 was detected. The results showed that all tested isolates had toxigenic potential for fumonisin B1 production. The average fumonisin B1 production of the isolates ranged from 7 to 289 μg/kg, thus indicating a highly variable toxigenic potential among the isolates. Isolate 1282 expressed the highest toxigenic potential for fumonisin B1 production (289 μg/kg), while isolate 2533/A showed a questionable potential for fumonisin production (7 μg/kg). [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. TR 31023]
- Published
- 2017
- Full Text
- View/download PDF
42. Determination of multiple mycotoxins in maize using quechers sample preparation and LC-MS/MS detection
- Author
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Vuković Gorica Lj., Kos Jovana J., Bursić Vojislava P., Čolović Radmilo R., Vukmirović Đuro M., Jajić Igor M., and Krstović Saša Z.
- Subjects
AFѕ ,DON ,ZEA ,FBs ,QuEChERS ,maize ,LC-MS/MS ,Science (General) ,Q1-390 - Abstract
A reliable and easy method has been used for the multiple mycotoxins determination of AFs, DON, ZEA and FBs in maize samples. Liquid chromatography coupled mass spectrometry (LC-MS/MS) was used. Mycotoxins have been extracted from maize using a QuEChERS-based extraction procedure. All validation parameters were in accordance with Reg. (EC) No 401/2006. The analyses of eight maize seed samples showed the AFs, DON, ZEA and FBs contamination with the values below the state limit standards.
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- 2017
- Full Text
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43. Deoxynivalenol occurrence in Serbian maize under different weather conditions
- Author
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Jajić Igor M., Krstović Saša Z., Jakšić Sandra M., Vuković Gorica Lj., Bursić Vojislava P., and Guljaš Darko M.
- Subjects
deoxynivalenol ,HPLC ,maize ,Serbia ,weather ,Science (General) ,Q1-390 - Abstract
The aim of this paper was to investigate deoxynivalenol (DON) occurrence in maize samples originating from two harvest seasons in Serbia. The key differences between harvest seasons were weather conditions, specifically the humidity. The samples were analyzed using high performance liquid chromatography with DAD detection, after clean-up on SPE columns. In samples from 2014, DON was found in 82 (100.0%) samples with the average content of 2.517 mg/kg (ranged from 0.368 to 11.343 mg/kg). Two samples exceeded maximum level permitted by EU regulations. However, analyzing larger number of samples (163) from 2015 harvest season, DON was present in 51 (31.3%) samples in significantly lower concentrations (average of 0.662 mg/kg, ranged from 0.106 to 2.628 mg/kg). None of the samples from 2015 exceeded maximum level permitted by EU regulations. The data on DON presence in Serbian maize were in relation to the different weather conditions that prevailed during the two harvest seasons. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 172042]
- Published
- 2017
- Full Text
- View/download PDF
44. Application of ATR-FTIR analysis for determination of fumonisins in corn
- Author
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Jakšić Sandra M., Jajić Igor M., Despotović Vesna N., Živkov-Baloš Milica M., Stojanov Igor M., Krstović Saša Z., Mašić Zoran S., and Abramović Biljana F.
- Subjects
ATR-FTIR ,fumonisins ,corn ,Science (General) ,Q1-390 - Abstract
In order to develop rapid, inexpensive and, at the same time, reliable method for the analysis of molds of the genus Fusarium as an indicator of the presence of fumonisins in corn samples, possible application of Fourier transform infrared spectroscopy (FTIR) with attenuated total reflection (ATR) technique was examined. The content of fumonisins in contaminated corn samples had previously been quantified by ELISA method. At the spectrum of the sample contaminated with a high concentration of mycotoxins, there was a lack of the peak at 1,743 cm-1, but the peak was observed at 1709 cm-1. To the purpose of result classification the principal component analysis (PCA) and cluster analysis were applied. Conclusions of the two methods were similar both when applying ATR technique in the whole region of the spectrum (1,150-1,770 cm-1) and when the whole spectrum was divided into two regions: 1,150-1,450 and 1,450-1,770 cm-1. However, classification of samples was somewhat better in the ranges 1,150-1,770 and 1,450-1,770 cm-1 . Of the 16 analyzed corn samples, only very contaminated corn sample with 190 mg/kg was correctly classified as compared to the other samples with the content of less than 10 mg/kg. Also, it was found-passing recording of spectra of contaminated corn of the same genotype in order to avoid the possible impact of different hybrids on the spectrum. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. OI 172042]
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- 2017
- Full Text
- View/download PDF
45. Validation and application of FTIR spectroscopy in raw milk analysis
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Kučević Denis S., Glamočić Dragan M., Trivunović Snežana J., Jajić Igor M., Perišić Biljana Č., and Krstović Saša Z.
- Subjects
FTIR spectroscopy ,milk ,chemical parameters ,validation ,Technology (General) ,T1-995 - Abstract
The aim of this study was to investigate whether FTIR spectroscopy is an accurate and valid technique for the assessment of quality parameters in raw cow's milk: fat, protein, lactose, and total solids. The assessment was based on calibration series and comparison with reference material. Furthermore, it takes into account the results obtained in the inter-laboratory comparisons (proficiency testing). The calibration samples were purchased from the accredited regional reference laboratories. The validation parameters included linearity, accuracy, repeatability, reproducibility, and robustness. The linearity ratio was 0.95%. The biases calculated for the fat, protein, lactose and dry matter were -0.33, 0.31, -0.25, and 0.06 respectively. The F value from the F-test was used to determine the significant differences between two independent sets of the results. The obtained results were as follows: 1.469 for fat, 1.634 for protein, 1.192 for lactose, and 0.528 for dry matter. The intra-laboratory reproducibility calculated as the Horwitz Ratios for all parameters were within the criterion limits (0.5 to 0.8). The data obtained for carry-over were 0.27% for fat, 0.52% for protein, 0.47% for lactose, and 0.47% for dry matter. Based on the obtained results it can be concluded that the FTIR spectroscopy is a reliable instrumental technique for the determination of fat, protein, lactose and total solids in raw cow's milk.
- Published
- 2017
- Full Text
- View/download PDF
46. Preliminary Results on Deoxynivalenol Degradation in Maize by UVA and UVC Irradiation
- Author
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Jajić Igor, Jakšić Sandra, Krstović Saša, and Abramović Biljana
- Subjects
degradation ,deoxynivalenol ,maize ,ultra-violet irradiation ,Agriculture - Abstract
The aim of this work was to investigate the possibility of using UV irradiation for degradation of deoxynivalenol (DON) in naturally contaminated maize samples. The study was carried out by varying the distance of the contaminated maize from the UVA (368 nm) and UVC (254 nm) light source and duration of exposure of contaminated maize to UV irradiation. Two control samples of maize were used for the irradiation procedure, at DON levels of 1.902 mg/kg and 5.334 mg/kg. The samples were exposed to both UVA and UVC light at two different distances from UV lamp (15 and 30 cm) during three exposure intervals (30, 60 and 120 minutes). After irradiation DON content was determinated so the reduction levels could be quantified. Generally, the results showed reduced DON content in treated samples, but they were not consistent. The most probable reason for this was a very uneven DON distribution in naturally contaminated samples. For this reason, further research must be performed and should include irradiation of artificially inoculated samples with consistent DON distribution, the amount of irradiated sample needs to be enlarged and the higher number of replicates should be analyzed. As an additional improvement, an increase in frequency of sample mixing during the irradiation procedure needs to be done.
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- 2016
- Full Text
- View/download PDF
47. Mycobiota on common wheat ( Triticum aestivum) and spelt (Triticum aestivum ssp. spelta) grains from the region of Vojvodina in 2015
- Author
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Krulj Jelena A., Bočarov-Stančić Aleksandra S., Krstović Saša Z., Jajić Igor M., Kojić Jovana S., Vidaković Ana M., and Bodroža-Solarov Marija I.
- Subjects
mycobiota ,common wheat ,spelt ,Aspergillus flavus ,toxigenic potential ,Food processing and manufacture ,TP368-456 - Abstract
The incidence of mycobiota on common wheat (Triticum aestivum) and spelt (Triticum aestivum ssp. spelta) samples, collected during the harvest in 2015, was investigated. The obtained results showed that more genera of mycobiota were isolated from the common wheat grains than from the spelt grains. The most frequently isolated species from common wheat grains belonged to genus Alternaria (41.7%), followed by Fusarium (15.2%), while the incidence of this mycobiota on the spelt grains were 32.4% and 10.4%, respectively. Aspergillus flavus was identified in 40.0% wheat samples, with the incidence of 2.0%. Additionally, this study was undertaken in respect of the occurrence and toxigenic potential of A. flavus isolates from these small grain cereals. A simple screening method was applied to determine toxigenic profiles (aflatoxins production) of A. flavus isolates from common wheat. The results revealed the importance of precise investigation of mycobiota distribution on common wheat and spelt grains, and especially the investigation of toxigenic potential of A. flavus.
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- 2016
- Full Text
- View/download PDF
48. Wertung der biologischen und klinischen Parameter bei Kranken mit chronischer Polyarthritis, die mit Chloroquin behandelt wurden.
- Author
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Jajic, I.
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- 1983
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- View/download PDF
49. Cutaneous fibrinolytic activity in primary hypertrophic osteoarthropathy.
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Matucci-Cerinic, M., Lotti, T., Jajic, I., Di Lollo, S., Brunetti, L., and Orlic, D.
- Published
- 1987
- Full Text
- View/download PDF
50. Primary Hypertrophic Osteoarthropathy: Clinical, Radiologic, and Scintigraphic Characteristics
- Author
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Jajic, Z., Jajic, I., and Nemcic, T.
- Published
- 2001
- Full Text
- View/download PDF
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