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2. ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and Th2 Immune Responses

Author

Jaiswal, Anil Kumar and Mishra, Amarjit

Subjects
Medical research -- Comparative analysis, Medicine, Experimental -- Comparative analysis, Coronary heart disease -- Development and progression, T cells -- Comparative analysis, Inflammation -- Development and progression, Immune response -- Comparative analysis, Enzyme-linked immunosorbent assay -- Comparative analysis, Dendritic cells -- Comparative analysis, Enzymes -- Comparative analysis, Allergens -- Comparative analysis, Asthma -- Development and progression, Health
Abstract

Purpose ADAMTS7 is a secreted metalloproteinase enzyme and proteoglycan associated with the early progression of coronary artery disease. However, there is limited information regarding the role of ADAMTS7 in lung adaptive immunity and inflammation. Thus, we sought to assess whether ADAMTS7 expression in the lung modulates house dust mite (HDM)-induced airway inflammation and Th2 immune response. Methods The role of ADAMTS7 in HDM-induced airway disease was assessed in ADAMTS7-deficient (ADAMTS7.sup.-/-) mice and compared with the wild-type control mice by flow cytometry, ELISA, and histopathology. Furthermore, the antigen priming capability of dendritic cells (DC) was determined ex vivo by employing coculture with CD4.sup.+ OT-II cells. Results ADAMTS7.sup.-/- mice develop an augmented eosinophilic airway inflammation, mucous cell metaplasia, and increased Th2 immune response to inhaled HDM. In addition, allergen uptake by lung DC and migration to draining mediastinal lymph node were significantly increased in ADAMTS7.sup.-/- mice, which shows an enhanced capacity to mount allergen-specific T-cell proliferation and effector Th2 cytokine productions. We propose that the mechanism by which ADAMTS7 negatively regulates DC function involves attenuated antigen uptake and presentation capabilities, which reduces allergic sensitization and Th2 immune responses in the lung. Conclusion In aggregate, we provide compelling evidence that ADAMTS7 plays a pivotal role in allergic airway disease and Th2 immunity and would be an attractive target for asthma., Author(s): Anil Kumar Jaiswal [sup.1], Amarjit Mishra [sup.1] Author Affiliations: (1) grid.252546.2, 0000 0001 2297 8753, Laboratory of Lung Inflammation, Department of Pathobiology, College of Veterinary Medicine, Auburn University, , [...]

Published
2022
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16. Distributed Cost-Based Scheduling in Cloud Computing Environment

Author

Rupali and Jaiswal, Anil Kumar

Abstract

Cloud computing can be defined as one of the prominent technologies that lets a user change, configure and access the services online. it can be said that this is a prototype of computing that helps in saving cost and time of a user practically the use of cloud computing can be found in various fields like education, health, banking etc. Cloud computing is an internet dependent technology thus it is the major responsibility of Cloud Service Providers(CSPs) to care of data stored by user at data centers. Scheduling in cloud computing environment plays a vital role as to achieve maximum utilization and user satisfaction cloud providers need to schedule resources effectively. Job scheduling for cloud computing is analyzed in the following work. To complete, recreate the task calculation, and conveyed scheduling methods CloudSim3.0.3 is utilized. This research work discusses the job scheduling for circulated processing condition also by exploring on this issue we find it works with minimum time and less cost. In this work two load balancing techniques have been employed: ‘Throttled stack adjustment policy’ and ‘Active VM load balancing policy’ with two brokerage services ‘Advanced Response Time’ and ‘Reconfigure Dynamically’ to evaluate the VM_Cost, DC_Cost, Response Time, and Data Processing Time. The proposed techniques are compared with Round Robin scheduling policy.

Published
2019
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38. Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) level determines steroid-resistant airway inflammation in aging.

Author

Jaiswal AK, Yadav J, Makhija S, Sandey M, Suryawanshi A, Mitra AK, and Mishra A

Subjects
Animals, Antigen Presentation drug effects, Cell Movement drug effects, Dendritic Cells drug effects, Dendritic Cells pathology, Dermatophagoides pteronyssinus drug effects, Dexamethasone pharmacology, Eosinophils drug effects, Eosinophils pathology, Epithelial Cells drug effects, Epithelial Cells metabolism, Glycolysis drug effects, Granuloma pathology, Lymph Nodes pathology, Mediastinum pathology, Models, Biological, Respiratory System parasitology, Aging pathology, Glycoproteins metabolism, Inflammation pathology, Phosphoproteins metabolism, Respiratory System pathology, Steroids pharmacology
Abstract

Asthma and its heterogeneity change with age. Increased airspace neutrophil numbers contribute to severe steroid-resistant asthma exacerbation in the elderly, which correlates with the changes seen in adults with asthma. However, whether that resembles the same disease mechanism and pathophysiology in aged and adults is poorly understood. Here, we sought to address the underlying molecular mechanism of steroid-resistant airway inflammation development and response to corticosteroid (Dex) therapy in aged mice. To study the changes in inflammatory mechanism, we used a clinically relevant treatment model of house-dust mite (HDM)-induced allergic asthma and investigated lung adaptive immune response in adult (20-22 wk old) and aged (80-82 wk old) mice. Our result indicates an age-dependent increase in airway hyperresponsiveness (AHR), mixed granulomatous airway inflammation comprising eosinophils and neutrophils, and Th1/Th17 immune response with progressive decrease in frequencies and numbers of HDM-bearing dendritic cells (DC) accumulation in the draining lymph node (DLn) of aged mice as compared with adult mice. RNA-Seq experiments of the aged lung revealed short palate, lung, and nasal epithelial clone 1 (SPLUNC1) as one of the steroid-responsive genes, which progressively declined with age and further by HDM-induced inflammation. Moreover, we found increased glycolytic reprogramming, maturation/activation of DCs, the proliferation of OT-II cells, and Th2 cytokine secretion with recombinant SPLUNC1 (rSPLUNC1) treatment. Our results indicate a novel immunomodulatory role of SPLUNC1 regulating metabolic adaptation/maturation of DC. An age-dependent decline in the SPLUNC1 level may be involved in developing steroid-resistant airway inflammation and asthma heterogeneity.

Published
2022
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