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1. Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry.

Author

Harahsheh, Ashraf, Shah, Samay, Dallaire, Frederic, Manlhiot, Cedric, Khoury, Michael, Lee, Simon, Fabi, Marianna, Mauriello, Daniel, Tierney, Elif, Sabati, Arash, Dionne, Audrey, Dahdah, Nagib, Choueiter, Nadine, Thacker, Deepika, Giglia, Therese, Truong, Dongngan, Jain, Supriya, Portman, Michael, Orr, William, Harris, Tyler, Szmuszkovicz, Jacqueline, Farid, Pedrom, and McCrindle, Brian

Abstract

BACKGROUND: Patients with multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) have overlapping clinical features. We compared demographics, clinical presentation, management, and outcomes of patients according to evidence of previous SARS-CoV-2 infection. METHODS: The International Kawasaki Disease Registry (IKDR) enrolled KD and MIS-C patients from sites in North, Central, and South America, Europe, Asia, and the Middle East. Evidence of previous infection was defined as: Positive (household contact or positive polymerase chain reaction [PCR]/serology), Possible (suggestive clinical features of MIS-C and/or KD with negative PCR or serology but not both), Negative (negative PCR and serology and no known exposure), and Unknown (incomplete testing and no known exposure). RESULTS: Of 2345 enrolled patients SARS-CoV-2 status was Positive for 1541 (66%) patients, Possible for 89 (4%), Negative for 404 (17%) and Unknown for 311 (13%). Clinical outcomes varied significantly among the groups, with more patients in the Positive/Possible groups presenting with shock, having admission to intensive care, receiving inotropic support, and having longer hospital stays. Regarding cardiac abnormalities, patients in the Positive/Possible groups had a higher prevalence of left ventricular dysfunction, and patients in the Negative and Unknown groups had more severe coronary artery abnormalities. CONCLUSIONS: There appears to be a spectrum of clinical features from MIS-C to KD with a great deal of heterogeneity, and one primary differentiating factor is evidence for previous acute SARS-CoV-2 infection/exposure. SARS-CoV-2 Positive/Possible patients had more severe presentations and required more intensive management, with a greater likelihood of ventricular dysfunction but less severe coronary artery adverse outcomes, in keeping with MIS-C.

Published
2023

2. Cardiac Biomarkers Aid in Differentiation of Kawasaki Disease from Multisystem Inflammatory Syndrome in Children Associated with COVID-19

Author

Walton, Mollie, Raghuveer, Geetha, Harahsheh, Ashraf, Portman, Michael A., Lee, Simon, Khoury, Michael, Dahdah, Nagib, Fabi, Marianna, Dionne, Audrey, Harris, Tyler H., Choueiter, Nadine, Garrido-Garcia, Luis Martin, Jain, Supriya, Dallaire, Frédéric, Misra, Nilanjana, Hicar, Mark D., Giglia, Therese M., Truong, Dongngan T., Tierney, Elif Seda Selamet, Thacker, Deepika, Nowlen, Todd T., Szmuszkovicz, Jacqueline R., Norozi, Kambiz, Orr, William B., Farid, Pedrom, Manlhiot, Cedric, and McCrindle, Brian W.

Published
2023
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3. Cardiac manifestations and outcomes of COVID-19 vaccine-associated myocarditis in the young in the USA: longitudinal results from the Myocarditis After COVID Vaccination (MACiV) multicenter study

Author

Jain, Supriya S., Anderson, Steven A., Steele, Jeremy M., Wilson, Hunter C., Muniz, Juan Carlos, Soslow, Jonathan H., Beroukhim, Rebecca S., Maksymiuk, Victoria, Jacquemyn, Xander, Frosch, Olivia H., Fonseca, Brian, Harahsheh, Ashraf S., Buddhe, Sujatha, Ashwath, Ravi C., Thacker, Deepika, Maskatia, Shiraz A., Misra, Nilanjana, Su, Jennifer A., Siddiqui, Saira, Vaiyani, Danish, Vaikom-House, Aswathy K., Campbell, M. Jay, Klein, Jared, Huang, Sihong, Mathis, Christopher, Cornicelli, Matthew D., Sharma, Madhu, Nagaraju, Lakshmi, Ang, Jocelyn Y., Uppu, Santosh C., Ramachandran, Preeti, Patel, Jyoti K., Han, Frank, Mandell, Jason G., Akam-Venkata, Jyothsna, DiLorenzo, Michael P., Brumund, Michael, Bhatla, Puneet, Eshtehardi, Parham, Mehta, Karina, Glover, Katherine, Dove, Matthew L., Aldawsari, Khalifah A., Kumar, Anupam, Barfuss, Spencer B., Dorfman, Adam L., Minocha, Prashant K., Yonts, Alexandra B., Schauer, Jenna, Cheng, Andrew L., Robinson, Joshua D., Powell, Zachary, Srivastava, Shubhika, Chelliah, Anjali, Sanil, Yamuna, Hernandez, Lazaro E., Gaur, Lasya, Antonchak, Michael, Johnston, Marla, Reich, Jonathan D., Nair, Narayan, Drugge, Elizabeth D., and Grosse-Wortmann, Lars

Published
2024
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4. Association of Acute Anti-inflammatory Treatment With Medium-term Outcomes for Coronary Artery Aneurysms in Kawasaki Disease.

Author

Friedman, Kevin, McCrindle, Brian, Runeckles, Kyle, Dahdah, Nagib, Harahsheh, Ashraf, Khoury, Michael, Lang, Sean, Manlhiot, Cedric, Tremoulet, Adriana, Raghuveer, Geetha, Selamet Tierney, Elif, Jone, Pei-Ni, Li, Jennifer, Szmuszkovicz, Jacqueline, Norozi, Kambiz, Jain, Supriya, Yetman, Angela, and Newburger, Jane

Abstract

BACKGROUND: The impact of adjunctive anti-inflammatory treatment on outcomes for patients with Kawasaki disease (KD) and coronary artery aneurysms (CAAs) is unknown. METHODS: Using data from the International KD Registry in patients with ≥ medium CAA we evaluate associations of treatment with outcomes and major adverse cardiac events (MACE). RESULTS: Medium or large CAA was present in 527 (32%) patients. All were treated with intravenous immunoglobulin (IVIG), 70% were male, and the median age was 1.3 years (interquartile range: 0.4-4.0 years). The most common acute therapies included single IVIG alone in 243 (46%), multiple IVIG in 100 (19%), multiple IVIG + corticosteroids in 75 (14%), and multiple IVIG + infliximab + corticosteroids in 44 (8%) patients. Patients who received therapy beyond single IVIG had a larger CA z-score at baseline (P < 0.001) and a higher rate of bilateral CAA (P < 0.001). Compared with IVIG alone, early adjunctive treatments (within 3 days of initial IVIG) were not associated with time to CAA regression or MACE, whereas later adjunctive therapy was associated with MACE and longer time to CAA regression. Patients receiving IVIG plus steroids vs IVIG alone had a trend towards shorter time to CAA regression and lower risk of MACE (P = 0.07). A larger CAA z-score at baseline was the strongest predictor of an increase in the CAA z-score over follow-up, lower likelihood of CAA regression, and higher risk of MACE. CONCLUSIONS: Persistence of CAA and MACE are more strongly associated with baseline severity CAA than with acute adjuvant anti-inflammatory therapy. Patients who received late adjunctive therapy are at higher risk for worse outcomes.

Published
2022

6. COVID-19 Positive Versus Negative Complete Kawasaki Disease: A Study from the International Kawasaki Disease Registry

Author

Jose, Jerin, Tierney, Elif Seda Selamet, Harahsheh, Ashraf S., Dahdah, Nagib, Raghuveer, Geetha, Friedman, Kevin G., Khoury, Michael, Hicar, Mark D., Merves, Shae A., Dallaire, Frederic, Farid, Pedrom, Manlhiot, Cedric, Runeckles, Kyle, Misra, Nilanjana, Portman, Michael, Ballweg, Jean A., Lee, Simon, Jain, Supriya S., Harris, Tyler H., Szmuszkovicz, Jacqueline R., Orr, William, Larios, Guillermo, and McCrindle, Brian W.

Published
2023
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7. Design and implementation of multicenter pediatric and congenital studies with cardiovascular magnetic resonance: Big data in smaller bodies

Author

DiLorenzo, Michael P., Lee, Simon, Rathod, Rahul H., Raimondi, Francesca, Farooqi, Kanwal M., Jain, Supriya S., Samyn, Margaret M., Johnson, Tiffanie R., Olivieri, Laura J., Fogel, Mark A., Lai, Wyman W., Renella, Pierangelo, Powell, Andrew J., Buddhe, Sujatha, Stafford, Caitlin, Johnson, Jason N., Helbing, Willem A., Pushparajah, Kuberan, Voges, Inga, Muthurangu, Vivek, Miles, Kimberley G., Greil, Gerald, McMahon, Colin J., Slesnick, Timothy C., Fonseca, Brian M., Morris, Shaine A., Soslow, Jonathan H., Grosse-Wortmann, Lars, Beroukhim, Rebecca S., and Grotenhuis, Heynric B.

Published
2024
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8. Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry

Author

Alsalehi, Mahmoud, Ballweg, Jean A., Barnes, Benjamin, Braunlin, Elizabeth, Buffone, Ashley, Bustamante-Ogando, Juan Carlos, Chang, Arthur J., Corral, Nicolas, Dancey, Paul, El-Ganzoury, Mona, El-Samman, Nora, Elias, Matthew, Fernandez-Cooke, Elisa, Friedman, Kevin, Garrido-Garcia, Luis Martin, Garrido, Luis Martin, Goldenberg, Guillermo Larios, Grcic, Michelle M., Harris, Kevin C., Hicar, Mark D., Hindt, Bridgette, Jone, Pei-Ni, Kajimoto, Hidemi, Kaneta, Kelli, Khare, Manaswitha, Knutson, Stacie, Kutty, Shelby, Lanari, Marcello, Maksymiuk, Victoria, McHugh, Kimberly E., Merves, Shae, Misra, Nilanjana, Mohandas, Sindhu, Mondal, Tapas, Norozi, Kambiz, Nowlen, Todd, Pagano, Joseph J., Prasad, Deepa, Raghuveer, Geetha, Ravi, Prasad, Sundaram, Balasubramanian, Sehgal, Anupam, Shah, Ashish, Vázquez, Belén Toral, Tremoulet, Adriana H., Venkataraman, Aishwarya, Watelle, Laurence, Yamazaki-Naksahimada, Marco Antonio, Yetman, Anji T., Harahsheh, Ashraf S., Shah, Samay, Dallaire, Frederic, Manlhiot, Cedric, Khoury, Michael, Lee, Simon, Fabi, Marianna, Mauriello, Daniel, Tierney, Elif Seda Selamet, Sabati, Arash A., Dionne, Audrey, Dahdah, Nagib, Choueiter, Nadine, Thacker, Deepika, Giglia, Therese M., Truong, Dongngan T., Jain, Supriya, Portman, Michael, Orr, William B., Harris, Tyler H., Szmuszkovicz, Jacqueline R., Farid, Pedrom, and McCrindle, Brian W.

Published
2024
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10. Emerging Insights Into the Pathophysiology of Multisystem Inflammatory Syndrome Associated With COVID-19 in Children

Author

Lin, Justin, Harahsheh, Ashraf S., Raghuveer, Geetha, Jain, Supriya, Choueiter, Nadine F., Garrido-Garcia, Luis Martin, Dahdah, Nagib, Portman, Michael A., Misra, Nilanjana, Khoury, Michael, Fabi, Marianna, Elias, Matthew D., Dionne, Audrey, Lee, Simon, Tierney, Elif Seda Selamet, Ballweg, Jean A., Manlhiot, Cedric, and McCrindle, Brian W.

Published
2023
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11. Survival in Patients With Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient.

Author

Sperduto, Paul W, Mesko, Shane, Li, Jing, Cagney, Daniel, Aizer, Ayal, Lin, Nancy U, Nesbit, Eric, Kruser, Tim J, Chan, Jason, Braunstein, Steve, Lee, Jessica, Kirkpatrick, John P, Breen, Will, Brown, Paul D, Shi, Diana, Shih, Helen A, Soliman, Hany, Sahgal, Arjun, Shanley, Ryan, Sperduto, William A, Lou, Emil, Everett, Ashlyn, Boggs, Drexell H, Masucci, Laura, Roberge, David, Remick, Jill, Plichta, Kristin, Buatti, John M, Jain, Supriya, Gaspar, Laurie E, Wu, Cheng-Chia, Wang, Tony JC, Bryant, John, Chuong, Michael, An, Yi, Chiang, Veronica, Nakano, Toshimichi, Aoyama, Hidefumi, and Mehta, Minesh P

Subjects
Cancer, Rare Diseases, Brain Disorders, Brain Cancer, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Aged, Aged, 80 and over, Brain Neoplasms, Female, Humans, Karnofsky Performance Status, Male, Middle Aged, Multivariate Analysis, Neoplasm Grading, Neoplasms, Precision Medicine, Prognosis, Proportional Hazards Models, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeConventional wisdom has rendered patients with brain metastases ineligible for clinical trials for fear that poor survival could mask the benefit of otherwise promising treatments. Our group previously published the diagnosis-specific Graded Prognostic Assessment (GPA). Updates with larger contemporary cohorts using molecular markers and newly identified prognostic factors have been published. The purposes of this work are to present all the updated indices in a single report to guide treatment choice, stratify research, and define an eligibility quotient to expand eligibility.MethodsA multi-institutional database of 6,984 patients with newly diagnosed brain metastases underwent multivariable analyses of prognostic factors and treatments associated with survival for each primary site. Significant factors were used to define the updated GPA. GPAs of 4.0 and 0.0 correlate with the best and worst prognoses, respectively.ResultsSignificant prognostic factors varied by diagnosis and new prognostic factors were identified. Those factors were incorporated into the updated GPA with robust separation (P < .01) between subgroups. Survival has improved, but varies widely by GPA for patients with non-small-cell lung, breast, melanoma, GI, and renal cancer with brain metastases from 7-47 months, 3-36 months, 5-34 months, 3-17 months, and 4-35 months, respectively.ConclusionMedian survival varies widely and our ability to estimate survival for patients with brain metastases has improved. The updated GPA (available free at brainmetgpa.com) provides an accurate tool with which to estimate survival, individualize treatment, and stratify clinical trials. Instead of excluding patients with brain metastases, enrollment should be encouraged and those trials should be stratified by the GPA to ensure those trials make appropriate comparisons. Furthermore, we recommend the expansion of eligibility to allow for the enrollment of patients with previously treated brain metastases who have a 50% or greater probability of an additional year of survival (eligibility quotient > 0.50).

Published
2020

12. Estrogen/progesterone receptor and HER2 discordance between primary tumor and brain metastases in breast cancer and its effect on treatment and survival.

Author

Sperduto, Paul W, Mesko, Shane, Li, Jing, Cagney, Daniel, Aizer, Ayal, Lin, Nancy U, Nesbit, Eric, Kruser, Tim J, Chan, Jason, Braunstein, Steve, Lee, Jessica, Kirkpatrick, John P, Breen, Will, Brown, Paul D, Shi, Diana, Shih, Helen A, Soliman, Hany, Sahgal, Arjun, Shanley, Ryan, Sperduto, William, Lou, Emil, Everett, Ashlyn, Boggs, Drexell Hunter, Masucci, Laura, Roberge, David, Remick, Jill, Plichta, Kristin, Buatti, John M, Jain, Supriya, Gaspar, Laurie E, Wu, Cheng-Chia, Wang, Tony JC, Bryant, John, Chuong, Michael, Yu, James, Chiang, Veronica, Nakano, Toshimichi, Aoyama, Hidefumi, and Mehta, Minesh P

Subjects
Humans, Breast Neoplasms, Brain Neoplasms, Receptor, erbB-2, Receptors, Progesterone, Estrogens, Retrospective Studies, Biomarkers, Tumor, brain metastases, breast cancer, estrogen/progesterone/HER2 receptor discordance, Receptor, ErbB-2, Breast Cancer, Cancer, Clinical Trials and Supportive Activities, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundBreast cancer treatment is based on estrogen receptors (ERs), progesterone receptors (PRs), and human epidermal growth factor receptor 2 (HER2). At the time of metastasis, receptor status can be discordant from that at initial diagnosis. The purpose of this study was to determine the incidence of discordance and its effect on survival and subsequent treatment in patients with breast cancer brain metastases (BCBM).MethodsA retrospective database of 316 patients who underwent craniotomy for BCBM between 2006 and 2017 was created. Discordance was considered present if the ER, PR, or HER2 status differed between the primary tumor and the BCBM.ResultsThe overall receptor discordance rate was 132/316 (42%), and the subtype discordance rate was 100/316 (32%). Hormone receptors (HR, either ER or PR) were gained in 40/160 (25%) patients with HR-negative primary tumors. HER2 was gained in 22/173 (13%) patients with HER2-negative primary tumors. Subsequent treatment was not adjusted for most patients who gained receptors-nonetheless, median survival (MS) improved but did not reach statistical significance (HR, 17-28 mo, P = 0.12; HER2, 15-19 mo, P = 0.39). MS for patients who lost receptors was worse (HR, 27-18 mo, P = 0.02; HER2, 30-18 mo, P = 0.08).ConclusionsReceptor discordance between primary tumor and BCBM is common, adversely affects survival if receptors are lost, and represents a missed opportunity for use of effective treatments if receptors are gained. Receptor analysis of BCBM is indicated when clinically appropriate. Treatment should be adjusted accordingly.Key points1. Receptor discordance alters subtype in 32% of BCBM patients.2. The frequency of receptor gain for HR and HER2 was 25% and 13%, respectively.3. If receptors are lost, survival suffers. If receptors are gained, consider targeted treatment.

Published
2020

13. Beyond an Updated Graded Prognostic Assessment (Breast GPA): A Prognostic Index and Trends in Treatment and Survival in Breast Cancer Brain Metastases From 1985 to Today.

Author

Sperduto, Paul W, Mesko, Shane, Li, Jing, Cagney, Daniel, Aizer, Ayal, Lin, Nancy U, Nesbit, Eric, Kruser, Tim J, Chan, Jason, Braunstein, Steve, Lee, Jessica, Kirkpatrick, John P, Breen, Will, Brown, Paul D, Shi, Diana, Shih, Helen A, Soliman, Hany, Sahgal, Arjun, Shanley, Ryan, Sperduto, William, Lou, Emil, Everett, Ashlyn, Boggs, Drexell Hunter, Masucci, Laura, Roberge, David, Remick, Jill, Plichta, Kristin, Buatti, John M, Jain, Supriya, Gaspar, Laurie E, Wu, Cheng-Chia, Wang, Tony JC, Bryant, John, Chuong, Michael, Yu, James, Chiang, Veronica, Nakano, Toshimichi, Aoyama, Hidefumi, and Mehta, Minesh P

Subjects
Humans, Breast Neoplasms, Brain Neoplasms, BRCA1 Protein, Prognosis, Survival Analysis, Retrospective Studies, Aged, Aged, 80 and over, Middle Aged, Female, Rare Diseases, Clinical Research, Cancer, Breast Cancer, Other Physical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeBrain metastases are a common sequelae of breast cancer. Survival varies widely based on diagnosis-specific prognostic factors (PF). We previously published a prognostic index (Graded Prognostic Assessment [GPA]) for patients with breast cancer with brain metastases (BCBM), based on cohort A (1985-2007, n = 642), then updated it, reporting the effect of tumor subtype in cohort B (1993-2010, n = 400). The purpose of this study is to update the Breast GPA with a larger contemporary cohort (C) and compare treatment and survival across the 3 cohorts.Methods and materialsA multi-institutional (19), multinational (3), retrospective database of 2473 patients with breast cancer with newly diagnosed brain metastases (BCBM) diagnosed from January 1, 2006, to December 31, 2017, was created and compared with prior cohorts. Associations of PF and treatment with survival were analyzed. Kaplan-Meier survival estimates were compared with log-rank tests. PF were weighted and the Breast GPA was updated such that a GPA of 0 and 4.0 correlate with the worst and best prognoses, respectively.ResultsMedian survival (MS) for cohorts A, B, and C improved over time (from 11, to 14 to 16 months, respectively; P < .01), despite the subtype distribution becoming less favorable. PF significant for survival were tumor subtype, Karnofsky Performance Status, age, number of BCBMs, and extracranial metastases (all P < .01). MS for GPA 0 to 1.0, 1.5-2.0, 2.5-3.0, and 3.5-4.0 was 6, 13, 24, and 36 months, respectively. Between cohorts B and C, the proportion of human epidermal receptor 2 + subtype decreased from 31% to 18% (P < .01) and MS in this subtype increased from 18 to 25 months (P < .01).ConclusionsMS has improved modestly but varies widely by diagnosis-specific PF. New PF are identified and incorporated into an updated Breast GPA (free online calculator available at brainmetgpa.com). The Breast GPA facilitates clinical decision-making and will be useful for stratification of future clinical trials. Furthermore, these data suggest human epidermal receptor 2-targeted therapies improve clinical outcomes in some patients with BCBM.

Published
2020

14. Abstract 19107: Variation in Womenʼs Representation Among Leadership Positions in Pediatric Cardiology Programs Across North America

Author

Kipps, Alaina, Marshall, Audrey, Sachdeva, Ritu, Bansal, Neha, Bauser-Heaton, Holly, CHOUEITER, NADINE, Chowdhury, Devyani, Dalal, Aarti, Ehlrich, Molly S, Freud, Lindsay R, Jain, Supriya, Jone, Pei-Ni, laraja, kristin, Owens, Sonal, Lopez-Colon, Dalia, Ronai, Christina, Stiver, Corey, Sutton, Nicole J, and Co-Vu, Jennifer

Published
2023
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15. Abstract 15474: Factors Associated With Shock at Presentation for Patients With Kawasaki Disease versus Multisystem Inflammatory Syndrome in Children Associated With COVID-19

Author

Jain, Supriya S, Lowndes, Robert, grcic, michelle, Bashir, Ayisha, Garrido, Luis M, Dahdah, Nagib, Misra, Nilanjana, Pagano, Joseph J, Maksymiuk, Victoria, Jone, Pei-Ni, Prasad, Deepa, Harris, Tyler, Szmuszkovicz, Jacqueline R, Barnes, Benjamin, Mondal, Tapas K, Khare, Manaswitha, Truong, Dongngan, Farid, Pedrom, Manlhiot, Cedric, and McCrindle, Brian W

Published
2023
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16. Estimating survival in patients with gastrointestinal cancers and brain metastases: An update of the graded prognostic assessment for gastrointestinal cancers (GI-GPA).

Author

Sperduto, Paul W, Fang, Penny, Li, Jing, Breen, William, Brown, Paul D, Cagney, Daniel, Aizer, Ayal, Yu, James B, Chiang, Veronica, Jain, Supriya, Gaspar, Laurie E, Myrehaug, Sten, Sahgal, Arjun, Braunstein, Steve, Sneed, Penny, Cameron, Brent, Attia, Albert, Molitoris, Jason, Wu, Cheng-Chia, Wang, Tony JC, Lockney, Natalie A, Beal, Kathryn, Parkhurst, Jessica, Buatti, John M, Shanley, Ryan, Lou, Emil, Tandberg, Daniel D, Kirkpatrick, John P, Shi, Diana, Shih, Helen A, Chuong, Michael, Saito, Hirotake, Aoyama, Hidefumi, Masucci, Laura, Roberge, David, and Mehta, Minesh P

Subjects
Brain metastases, End-of-life, Gastrointestinal cancers, Prognosis, Cancer, Rare Diseases, Brain Disorders, Digestive Diseases, Clinical Research
Abstract

BackgroundPatients with gastrointestinal cancers and brain metastases (BM) represent a unique and heterogeneous population. Our group previously published the Diagnosis-Specific Graded Prognostic Assessment (DS-GPA) for patients with GI cancers (GI-GPA) (1985-2007, n = 209). The purpose of this study is to update the GI-GPA based on a larger contemporary database.MethodsAn IRB-approved consortium database analysis was performed using a multi-institutional (18), multi-national (3) cohort of 792 patients with gastrointestinal (GI) cancers, with newly-diagnosed BM diagnosed between 1/1/2006 and 12/31/2017. Survival was measured from date of first treatment for BM. Multiple Cox regression was used to select and weight prognostic factors in proportion to their hazard ratios. These factors were incorporated into the updated GI-GPA.ResultsMedian survival (MS) varied widely by primary site and other prognostic factors. Four significant factors (KPS, age, extracranial metastases and number of BM) were used to formulate the updated GI-GPA. Overall MS for this cohort remains poor; 8 months. MS by GPA was 3, 7, 11 and 17 months for GPA 0-1, 1.5-2, 2.5-3.0 and 3.5-4.0, respectively. >30% present in the worst prognostic group (GI-GPA of ≤1.0).ConclusionsBrain metastases are not uncommon in GI cancer patients and MS varies widely among them. This updated GI-GPA index improves our ability to estimate survival for these patients and will be useful for therapy selection, end-of-life decision-making and stratification for future clinical trials. A user-friendly, free, on-line app to calculate the GPA score and estimate survival for an individual patient is available at brainmetgpa.com.

Published
2019

17. Survival and prognostic factors in patients with gastrointestinal cancers and brain metastases: have we made progress?

Author

Sperduto, Paul W, Fang, Penny, Li, Jing, Breen, William, Brown, Paul D, Cagney, Daniel, Aizer, Ayal, Yu, James, Chiang, Veronica, Jain, Supriya, Gaspar, Laurie E, Myrehaug, Sten, Sahgal, Arjun, Braunstein, Steve, Sneed, Penny, Cameron, Brent, Attia, Albert, Molitoris, Jason, Wu, Cheng-Chia, Wang, Tony JC, Lockney, Natalie, Beal, Kathryn, Parkhurst, Jessica, Buatti, John M, Shanley, Ryan, Lou, Emil, Tandberg, Daniel D, Kirkpatrick, John P, Shi, Diana, Shih, Helen A, Chuong, Michael, Saito, Hirotake, Aoyama, Hidefumi, Masucci, Laura, Roberge, David, and Mehta, Minesh P

Subjects
Humans, Gastrointestinal Neoplasms, Brain Neoplasms, Prognosis, Cohort Studies, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Kaplan-Meier Estimate, Cancer, Rare Diseases, Digestive Diseases, Clinical Research, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Clinical Sciences, General Clinical Medicine
Abstract

The literature describing the prognosis of patients with gastrointestinal (GI) cancers and brain metastases (BM) is sparse. Our group previously published a prognostic index, the Graded Prognostic Assessment (GPA) for GI cancer patients with BM, based on 209 patients diagnosed from 1985-2005. The purpose of this analysis is to identify prognostic factors for GI cancer patients with newly diagnosed BM in a larger contemporary cohort. A multi-institutional retrospective IRB-approved database of 792 GI cancer patients with new BM diagnosed from 1/1/2006 to 12/31/2016 was created. Demographic data, clinical parameters, and treatment were correlated with survival and time from primary diagnosis to BM (TPDBM). Kaplan-Meier median survival (MS) estimates were calculated and compared with log-rank tests. The MS from time of first treatment for BM for the prior and current cohorts were 5 and 8 months, respectively (P < 0.001). Eight prognostic factors (age, stage, primary site, resection of primary tumor, Karnofsky Performance Status (KPS), extracranial metastases, number of BM and Hgb were found to be significant for survival, in contrast to only one (KPS) in the prior cohort. In this cohort, the most common primary sites were rectum (24%) and esophagus (23%). Median TPDBM was 22 months. Notably, 37% (267/716) presented with poor prognosis (GPA 0-1.0). Although little improvement in overall survival in this cohort has been achieved in recent decades, survival varies widely and multiple new prognostic factors were identified. Future work will translate these factors into a prognostic index to facilitate clinical decision-making and stratification of future clinical trials.

Published
2019

18. Accuracy of Cardiac Magnetic Resonance Imaging in Diagnosing Pediatric Cardiac Masses: A Multicenter Study

Author

Beroukhim, Rebecca S., Ghelani, Sunil, Ashwath, Ravi, Balasubramanian, Sowmya, Biko, David M., Buddhe, Sujatha, Campbell, M. Jay, Cross, Russell, Festa, Pierluigi, Griffin, Lindsay, Grotenhuis, Heynric, Hasbani, Keren, Hashemi, Sassan, Hegde, Sanjeet, Hussain, Tarique, Jain, Supriya, Kiaffas, Maria, Kutty, Shelby, Lam, Christopher Z., Liberato, Gabriela, Merlocco, Anthony, Misra, Nilanjana, Mowers, Katie L., Muniz, Juan Carlos, Nutting, Arni, Parra, David A., Patel, Jyoti K., Perez-Atayde, Antonio R., Prasad, Deepa, Rosental, Carlos F., Shah, Amee, Samyn, Margaret M., Sleeper, Lynn A., Slesnick, Timothy, Valsangiacomo, Emanuela, and Geva, Tal

Published
2022
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20. List of contributors

Author

Abo Dena, Ahmed S., primary, Abourehab, Mohammed A.S., additional, Abuwatfa, Waad H., additional, Agwa, Mona M., additional, Alexander, Amit, additional, Alghamdi, Maha Ali, additional, Alhamoud, Marah, additional, Ali, M. Azam, additional, AlSawaftah, Nour M., additional, Alsobyan, Faris Mohammed, additional, Aman, Waqar, additional, Amin, Mohd Cairul Iqbal Mohd, additional, Amjad, Muhammad Wahab, additional, Arafa, Kholoud K., additional, Ashi, Layal, additional, Bahman, Fatemah, additional, Bobde, Yamini, additional, Borchard, Gerrit, additional, Butt, Adeel Masood, additional, Dandela, Rambabu, additional, Deng, Xiaoxuan, additional, Dubey, Sunil Kumar, additional, Durgun, M. Ezgi, additional, El-Sherbiny, Ibrahim M., additional, Eslam, M.S., additional, Fang, Jun, additional, Farooq, Umer, additional, Fatima, Mahak, additional, Ghosh, Balaram, additional, Gould, Maree, additional, Gould, Maree L., additional, Greish, Khaled, additional, Güngör, Sevgi, additional, Haidar, Ziyad S., additional, Hazekawa, Mai, additional, Husseini, Ghaleb A., additional, Ishibashi, Daisuke, additional, Islam, Rayhanul, additional, Jain, Supriya, additional, Jasim, Anfal, additional, Johnson, Renjith P., additional, Kahraman, Emine, additional, Kanazawa, Takanori, additional, Kar, Ananya, additional, Kenguva, Gowtham, additional, Kesharwani, Prashant, additional, Khan, Arooj, additional, Khan, Rahima, additional, Kondapaneni, Likhitha Purna, additional, Mahmud, Amna Albu, additional, Marquet, Franck, additional, Mohamad, Najwa, additional, Nishinakagawa, Takuya, additional, Özsoy, Yıldız, additional, Pandey, Manisha, additional, Parayath, Neha N., additional, Pérez, Sebastián E., additional, Raja, Maria Abdul Ghafoor, additional, Raslan, Mohamed, additional, Rout, Smruti Rekha, additional, Sabra, Sally A., additional, Sabri, Nagwa A., additional, Sahebkar, Amirhossein, additional, Sara, A.R., additional, Singh, Vanshikha, additional, Talat, Maria, additional, Chen, Xiang Yi, additional, and Zaman, Muhammad, additional

Published
2022
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21. Contributors

Author

Agrawal, Aashruti, primary, Agustín, Rascón-Chu, additional, Ahmed, Hanan B., additional, Alke, Bhavna, additional, Alfonso, Sánchez-Villegas J., additional, Anil, Sukumaran, additional, Ankamwar, Balaprasad, additional, Arya, Geeta, additional, Bandopadhyay, Rajib, additional, Biswas, Raju, additional, Cao, Mengna, additional, Chakraborty, Soma, additional, D'Accorso, Norma B., additional, Dalavi, Pandurang A., additional, Dutta, Anurag, additional, Emam, Hossam E., additional, Ezzat, Shahira M., additional, Federico, Ohlmaier-Delgadillo, additional, Gabriel H., Gomez-Rodriguez, additional, Gadade, Dipak D., additional, Garcia, Nancy Lis, additional, Gu, Qing, additional, Guadalupe, Félix-Arias K., additional, Gupta, Nidhi, additional, Gupta, Surabhi, additional, Haggag, Yusuf, additional, Halder, Urmi, additional, Hu, Xiuting, additional, Jain, Harsha, additional, Jain, Supriya, additional, Jithin, M.V., additional, Johnson, Renjith P., additional, Kabiraj, Ashutosh, additional, Kulkarni, Deepak A., additional, Kusayin, Mikhail I., additional, Let, Moitri, additional, Lizeth, Lara-Espinoza Claudia, additional, Madan, Jitender, additional, Majhi, Krishnendu, additional, Manzano, Verónica E., additional, Mao, Shirui, additional, Miao, Ming, additional, Mondal, D.B., additional, Murugan, Sesha Subramanian, additional, Ni, Fangfang, additional, Nimesh, Surendra, additional, Pingle, Purva, additional, Prabhu, Ashwini, additional, Preman, Namitha K., additional, Purkayastha, Pradipta, additional, Raguavaran, R., additional, Ramirez, Carlos Rodriguez, additional, Rani, Vinitha, additional, Rasin, Anton B., additional, Rathi, Pavan B., additional, Repetto, Evangelina, additional, Salem, Mohamed A., additional, Sangshetti, Jaiprakash N., additional, Sanjeeva, Sandesh G., additional, Sarmah, Jayanta K., additional, Sarmah, Sanjib, additional, Sharma, D.K., additional, Sharma, Lokesh, additional, Shrivastava, Saurabh, additional, Sun, Yujiao, additional, Syed, Usman T., additional, Tagad, Chandrakant, additional, Taqui, Syed N., additional, Ukkund, Shareefraza J., additional, Ulber, Roland, additional, Usoltseva, Rosa V., additional, Venkatesan, Jayachandran, additional, Xie, Hujun, additional, Yadav, Awesh K., additional, Yadav, Narayani, additional, Zayed, Ahmed, additional, and Zuleth, Gomeztagle-Romero M., additional

Published
2022
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24. Design and implementation of multicenter pediatric and congenital studies with cardiovascular magnetic resonance: Big data in smaller bodies

Author

Cardiologie patientenzorg, Child Health, Circulatory Health, DiLorenzo, Michael P, Lee, Simon, Rathod, Rahul H, Raimondi, Francesca, Farooqi, Kanwal M, Jain, Supriya S, Samyn, Margaret M, Johnson, Tiffanie R, Olivieri, Laura J, Fogel, Mark A, Lai, Wyman W, Renella, Pierangelo, Powell, Andrew J, Buddhe, Sujatha, Stafford, Caitlin, Johnson, Jason N, Helbing, Willem A, Pushparajah, Kuberan, Voges, Inga, Muthurangu, Vivek, Miles, Kimberley G, Greil, Gerald, McMahon, Colin J, Slesnick, Timothy C, Fonseca, Brian M, Morris, Shaine A, Soslow, Jonathan H, Grosse-Wortmann, Lars, Beroukhim, Rebecca S, Grotenhuis, Heynric B, Cardiologie patientenzorg, Child Health, Circulatory Health, DiLorenzo, Michael P, Lee, Simon, Rathod, Rahul H, Raimondi, Francesca, Farooqi, Kanwal M, Jain, Supriya S, Samyn, Margaret M, Johnson, Tiffanie R, Olivieri, Laura J, Fogel, Mark A, Lai, Wyman W, Renella, Pierangelo, Powell, Andrew J, Buddhe, Sujatha, Stafford, Caitlin, Johnson, Jason N, Helbing, Willem A, Pushparajah, Kuberan, Voges, Inga, Muthurangu, Vivek, Miles, Kimberley G, Greil, Gerald, McMahon, Colin J, Slesnick, Timothy C, Fonseca, Brian M, Morris, Shaine A, Soslow, Jonathan H, Grosse-Wortmann, Lars, Beroukhim, Rebecca S, and Grotenhuis, Heynric B

Published
2024

25. Design and implementation of multicenter pediatric and congenital studies with cardiovascular magnetic resonance:Big data in smaller bodies

Author

DiLorenzo, Michael P., Lee, Simon, Rathod, Rahul H., Raimondi, Francesca, Farooqi, Kanwal M., Jain, Supriya S., Samyn, Margaret M., Johnson, Tiffanie R., Olivieri, Laura J., Fogel, Mark A., Lai, Wyman W., Renella, Pierangelo, Powell, Andrew J., Buddhe, Sujatha, Stafford, Caitlin, Johnson, Jason N., Helbing, Willem A., Pushparajah, Kuberan, Voges, Inga, Muthurangu, Vivek, Miles, Kimberley G., Greil, Gerald, McMahon, Colin J., Slesnick, Timothy C., Fonseca, Brian M., Morris, Shaine A., Soslow, Jonathan H., Grosse-Wortmann, Lars, Beroukhim, Rebecca S., Grotenhuis, Heynric B., DiLorenzo, Michael P., Lee, Simon, Rathod, Rahul H., Raimondi, Francesca, Farooqi, Kanwal M., Jain, Supriya S., Samyn, Margaret M., Johnson, Tiffanie R., Olivieri, Laura J., Fogel, Mark A., Lai, Wyman W., Renella, Pierangelo, Powell, Andrew J., Buddhe, Sujatha, Stafford, Caitlin, Johnson, Jason N., Helbing, Willem A., Pushparajah, Kuberan, Voges, Inga, Muthurangu, Vivek, Miles, Kimberley G., Greil, Gerald, McMahon, Colin J., Slesnick, Timothy C., Fonseca, Brian M., Morris, Shaine A., Soslow, Jonathan H., Grosse-Wortmann, Lars, Beroukhim, Rebecca S., and Grotenhuis, Heynric B.

Abstract

Cardiovascular magnetic resonance (CMR) has become the reference standard for quantitative and qualitative assessment of ventricular function, blood flow, and myocardial tissue characterization. There is a preponderance of large CMR studies and registries in adults; However, similarly powered studies are lacking for the pediatric and congenital heart disease (PCHD) population. To date, most CMR studies in children are limited to small single or multicenter studies, thereby limiting the conclusions that can be drawn. Within the PCHD CMR community, a collaborative effort has been successfully employed to recognize knowledge gaps with the aim to embolden the development and initiation of high-quality, large-scale multicenter research. In this publication, we highlight the underlying challenges and provide a practical guide toward the development of larger, multicenter initiatives focusing on PCHD populations, which can serve as a model for future multicenter efforts.

Published
2024

26. Abstract 11816: Association of Increased Adiposity and Presentation and Outcomes for Kawasaki Disease versus Multisystem Inflammatory Syndrome in Children Associated With Covid-19

Author

Khoury, Michael, Venkataraman, Aishwarya, Portman, Michael A, Fabi, Marianna, Dahdah, Nagib, Jain, Supriya, Jone, Pei-Ni, Raghuveer, Geetha, Lee, Simon, Prasad, Deepa, El Ganzoury, Mona, Yetman, Angela T, Friedman, Kevin G, Martin Garrido, Luis, Norozi, Kambiz, Sehgal, Anupam, Serrano, Ryan M, Kutty, Shelby, Farid, Pedrom, and McCrindle, Brian W

Published
2022
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27. Abstract 11464: Spectrum and Associated Factors for Coronary Artery Involvement in Kawasaki Disease versus Multisystem Inflammatory Syndrome in Children Associated With Covid-19

Author

Lee, Simon, Harahsheh, Ashraf S, Portman, Michael A, Fabi, Marianna, Jain, Supriya, El Ganzoury, Mona, Dionne, Audrey, Misra, Nilanjana, Nowlen, Todd, Elias, Matthew, Fernandez-Cooke, Elisa, Szmuszkovicz, Jacqueline R, Orr, William, Truong, Dongngan, McHugh, Kimberly E, Choueiter, Nadine, Shah, Surya, Manlhiot, Cedric, Farid, Pedrom, and McCrindle, Brian W

Published
2022
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29. Low-Molecular-Weight Heparin vs Warfarin for Thromboprophylaxis in Children With Coronary Artery Aneurysms After Kawasaki Disease: A Pragmatic Registry Trial

Author

Altman, Carolyn A., Anderson, Brett R., Braunlin, Elizabeth, Burns, Jane C., Carr, Michael R., Choueiter, Nadine F., Colyer, Jessica H., Crean, Andrew, Dempsey, Adam, Desjardins, Laurent, Dillenburg, Rejane, Dionne, Audrey, Ferris, Anna, Gewitz, Michael, Grcic, Michelle M., Greenway, Steven C., Hamel-Perrault, Elodie, Harris, Kevin C., Hayden-Rush, Christina, Hill, Kevin D., Jain, Supriya, Jone, Pei-Ni, Kimball, Thomas R., Lang, Sean M., Li, Jennifer S., Lin, Ming-Tai, Mahle, William T., McHugh, Kimberly E., Portman, Michael A., Renaud, Claudia, Sexson Tejitel, S. Kristen, Szmuszkovicz, Jacqueline R., Texter, Karen M., Thacker, Deepika, Selamet Tierney, Elif Seda, Thomas, Thomas, Tremoulet, Adriana H., Wagner-Lees, Sharon, Warren, Andrew, Manlhiot, Cedric, Newburger, Jane W., Low, Tisiana, Dahdah, Nagib, Mackie, Andrew S., Raghuveer, Geetha, Giglia, Therese M., Dallaire, Frederic, Mathew, Mathew, Runeckles, Kyle, Pahl, Elfriede, Harahsheh, Ashraf S., Norozi, Kambiz, de Ferranti, Sarah D., Friedman, Kevin, Yetman, Anji T., Kutty, Shelby, Mondal, Tapas, and McCrindle, Brian W.

Published
2020
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30. Clinically Suspected Myocarditis Temporally Related to COVID-19 Vaccination in Adolescents and Young Adults

Author

Truong, Dongngan T., Dionne, Audrey, Muniz, Juan Carlos, McHugh, Kimberly E., Portman, Michael A., Lambert, Linda M., Thacker, Deepika, Elias, Matthew D., Li, Jennifer S., Toro-Salazar, Olga H., Anderson, Brett R., Atz, Andrew M., Bohun, C. Monique, Campbell, M. Jay, Chrisant, Maryanne, D’Addese, Laura, Dummer, Kirsten B., Forsha, Daniel, Frank, Lowell H., Frosch, Olivia H., Gelehrter, Sarah K., Giglia, Therese M., Hebson, Camden, Jain, Supriya S., Johnston, Pace, Krishnan, Anita, Lombardi, Kristin C., McCrindle, Brian W., Mitchell, Elizabeth C., Miyata, Koichi, Mizzi, Trent, Parker, Robert M., Patel, Jyoti K., Ronai, Christina, Sabati, Arash A., Schauer, Jenna, Tejtel, S. Kristen Sexson, Shea, J. Ryan, Shekerdemian, Lara S., Srivastava, Shubhika, Votava-Smith, Jodie K., White, Sarah, and Newburger, Jane W.

Published
2021
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31. Outcomes in COVID-19 mRNA Vaccine-Associated Myocarditis in the Young in the United States:&nbsp;Results from The&nbsp;Myocarditis&nbsp;After&nbsp;COVID Vaccination (MACiV) Multicenter Longitudinal Study

Author

Jain, Supriya S., primary, Anderson, Steven A., additional, Steele, Jeremy, additional, Wilson, Hunter, additional, Muniz, Juan Carlos, additional, Soslow, Jonathan, additional, Beroukhim, Rebecca, additional, Maksymiuk, Victoria, additional, Jacquemyn, Xander, additional, Frosch, Olivia, additional, Fonseca, Brian, additional, Harahsheh, Ashraf S., additional, Buddhe, Sujatha, additional, Ashwath, Ravi, additional, Thacker, Deepika, additional, Maskatia, Shiraz, additional, Misra, Nilanjana, additional, Su, Jennifer, additional, Siddiqui, Saira, additional, Vaiyani, Danish, additional, Vaikom-House, Ashwathy, additional, Campbell, Michael, additional, Klein, Jared, additional, Huang, Sihong, additional, Mathis, Christopher, additional, Cornicelli, Matthew, additional, Sharma, Madhu, additional, Nagaraju, Lakshmi, additional, Ang, Jocelyn Y., additional, Uppu, Santosh, additional, Ramachandran, Preeti, additional, Patel, Jyoti, additional, Han, Frank, additional, Mandell, Jason, additional, Akam-Venkata, Jyothsna, additional, Dilorenzo, Michael, additional, Brumund, Michael, additional, Bhatla, Puneet, additional, Eshtehardi, Parham, additional, Mehta, Karina, additional, Glover, Katherine, additional, Dove, Matthew, additional, Aldawsari, Khalifah, additional, Kumar, Anupam, additional, Barfuss, Spencer, additional, Dorfman, Adam, additional, Minocha, Prashant, additional, Yonts, Alexandra, additional, Schauer, Jenna, additional, Cheng, Andrew, additional, Robinson, Joshua, additional, Powell, Zachary, additional, Srivastava, Shubhika, additional, Chelliah, Anjali, additional, Sanil, Yamuna, additional, Hernandez, Lazaro, additional, Antonchak, Michael, additional, Gaur, Lasya, additional, Johnston, Marla, additional, Reich, Jonathan D., additional, Nair, Narayan, additional, Drugge, Elizabeth, additional, and Grosse-Wortmann, Lars, additional

Published
2024
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33. Myocardial involvement in children with post-COVID multisystem inflammatory syndrome: a cardiovascular magnetic resonance based multicenter international study—the CARDOVID registry

Author

Aeschlimann, Florence A., Misra, Nilanjana, Hussein, Tarique, Panaioli, Elena, Soslow, Jonathan H., Crum, Kimberly, Steele, Jeremy M., Huber, Steffen, Marcora, Simona, Brambilla, Paolo, Jain, Supriya, Navallas, Maria, Giuli, Valentina, Rücker, Beate, Angst, Felix, Patel, Mehul D., Azarine, Arshid, Caro-Domínguez, Pablo, Cavaliere, Annachiara, Di Salvo, Giovanni, Ferroni, Francesca, Agnoletti, Gabriella, Bonnemains, Laurent, Martins, Duarte, Boddaert, Nathalie, Wong, James, Pushparajah, Kuberan, and Raimondi, Francesca

Published
2021
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34. Discovery potential for heavy t-tbar resonances in dilepton+jets final states

Author

Iashvili, Ia, Jain, Supriya, Kharchilava, Avto, and Prosper, Harrison B.

Subjects
High Energy Physics - Experiment
Abstract

We examine the prospects for probing heavy top quark-antiquark (t-tbar) resonances at the upgraded LHC in pp collisions at $\root_s = 14 TeV. Heavy t-tbar resonances (Z' bosons) are predicted by several theories that go beyond the standard model. We consider scenarios in which each top quark decays leptonically, either to an electron or a muon, and the data sets correspond to integrated luminosities of \int L dt = 300 /fb and \int L dt = 3000 /fb. We present the expected 5-sigma discovery potential for a Z' resonance as well as the expected upper limits at 95% C.L. on the Z' production cross section and mass in the absence of a discovery., Comment: 7 pages, 9 plots

Published
2013

35. Estimating survival in patients with gastrointestinal cancers and brain metastases: An update of the graded prognostic assessment for gastrointestinal cancers (GI-GPA)

Author

Sperduto, Paul W., Fang, Penny, Li, Jing, Breen, William, Brown, Paul D., Cagney, Daniel, Aizer, Ayal, Yu, James B., Chiang, Veronica, Jain, Supriya, Gaspar, Laurie E., Myrehaug, Sten, Sahgal, Arjun, Braunstein, Steve, Sneed, Penny, Cameron, Brent, Attia, Albert, Molitoris, Jason, Wu, Cheng-Chia, Wang, Tony J.C., Lockney, Natalie A., Beal, Kathryn, Parkhurst, Jessica, Buatti, John M., Shanley, Ryan, Lou, Emil, Tandberg, Daniel D., Kirkpatrick, John P., Shi, Diana, Shih, Helen A., Chuong, Michael, Saito, Hirotake, Aoyama, Hidefumi, Masucci, Laura, Roberge, David, and Mehta, Minesh P.

Published
2019
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36. Survival and prognostic factors in patients with gastrointestinal cancers and brain metastases: have we made progress?

Author

Sperduto, Paul W., Fang, Penny, Li, Jing, Breen, William, Brown, Paul D., Cagney, Daniel, Aizer, Ayal, Yu, James, Chiang, Veronica, Jain, Supriya, Gaspar, Laurie E., Myrehaug, Sten, Sahgal, Arjun, Braunstein, Steve, Sneed, Penny, Cameron, Brent, Attia, Albert, Molitoris, Jason, Wu, Cheng-Chia, Wang, Tony J.C., Lockney, Natalie, Beal, Kathryn, Parkhurst, Jessica, Buatti, John M., Shanley, Ryan, Lou, Emil, Tandberg, Daniel D., Kirkpatrick, John P., Shi, Diana, Shih, Helen A., Chuong, Michael, Saito, Hirotake, Aoyama, Hidefumi, Masucci, Laura, Roberge, David, and Mehta, Minesh P.

Published
2019
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37. Cross Sections for Leptophobic Topcolor Z' decaying to top-antitop

Author

Harris, Robert M. and Jain, Supriya

Subjects
High Energy Physics - Phenomenology
Abstract

We present numerical calculations of the production cross section of a heavy Z' resonance in hadron-hadron collisions with subsequent decay into top-antitop pairs. In particular, we consider the leptophobic topcolor Z' discussed under Model IV of hep-ph/9911288 which has predicted cross sections large enough to be experimentally accessible at the Fermilab Tevatron and the Large Hadron Collider at CERN. This article presents an updated calculation valid for the Tevatron and all proposed LHC collision energies. Cross sections are presented for various Z' widths, in p-pbar collisions at \sqrt{s}=2 TeV, and in p-p collisions at \sqrt{s}=7, 8, 10 and 14 TeV., Comment: 6 pages, 5 figures (Submitted to PRD); The European Physical Journal C, Volume 72, Issue 7

Published
2011
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38. Reference priors for high energy physics

Author

Demortier, Luc, Jain, Supriya, and Prosper, Harrison B.

Subjects
Statistics - Applications, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Data Analysis, Statistics and Probability
Abstract

Bayesian inferences in high energy physics often use uniform prior distributions for parameters about which little or no information is available before data are collected. The resulting posterior distributions are therefore sensitive to the choice of parametrization for the problem and may even be improper if this choice is not carefully considered. Here we describe an extensively tested methodology, known as reference analysis, which allows one to construct parametrization-invariant priors that embody the notion of minimal informativeness in a mathematically well-defined sense. We apply this methodology to general cross section measurements and show that it yields sensible results. A recent measurement of the single top quark cross section illustrates the relevant techniques in a realistic situation.

Published
2010
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41. Cardiac Biomarkers Aid in Differentiation of Kawasaki Disease from Multisystem Inflammatory Syndrome in Children Associated with COVID-19

Author

Walton, Mollie, primary, Raghuveer, Geetha, additional, Harahsheh, Ashraf, additional, Portman, Michael A., additional, Lee, Simon, additional, Khoury, Michael, additional, Dahdah, Nagib, additional, Fabi, Marianna, additional, Dionne, Audrey, additional, Harris, Tyler H., additional, Choueiter, Nadine, additional, Garrido-Garcia, Luis Martin, additional, Jain, Supriya, additional, Dallaire, Frédéric, additional, Misra, Nilanjana, additional, Hicar, Mark D., additional, Giglia, Therese M., additional, Truong, Dongngan T., additional, Tierney, Elif Seda Selamet, additional, Thacker, Deepika, additional, Nowlen, Todd T., additional, Szmuszkovicz, Jacqueline R., additional, Norozi, Kambiz, additional, Orr, William B., additional, Farid, Pedrom, additional, Manlhiot, Cedric, additional, McCrindle, Brian W., additional, Alsalehi, Mahmoud, additional, Ballweg, Jean A., additional, Barnes, Benjamin T., additional, Braunlin, Elizabeth, additional, Buffone, Ashley, additional, Bustamante-Ogando, Juan Carlos, additional, Chang, Arthur J., additional, Corral, Nicolas, additional, Cowles, Heather, additional, Dancey, Paul, additional, de Ferranti, Sarah D, additional, Ganzoury, Mona El, additional, Elias, Matthew, additional, Elsamman, Nora, additional, Cooke, Elisa Fernández, additional, Goldenberg, Guillermo Larios, additional, Grcic, Michelle M., additional, Harris, Kevin C., additional, Jone, Pei-Ni, additional, Kajimoto, Hidemi, additional, Khare, Manaswitha, additional, Kutty, Shelby, additional, Lanari, Marcello, additional, Mauriello, Daniel, additional, McHugh, Kimberly E., additional, Merves, Shae A., additional, Mohandas, Sindhu, additional, Mondal, Tapas, additional, Pagano, Joseph J., additional, Prasad, Deepa, additional, and Ravi, Prasad, additional

Published
2023
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42. Evidence for Single Top Production at the Tevatron

Author

Jain, Supriya

Subjects
High Energy Physics - Experiment
Abstract

We present first evidence for the production of single top quarks at the Fermilab Tevatron {\ppbar} collider. Both D0 and CDF experiments have measured the single top production cross section with a 3-standard-deviation significance using 0.9 fb$^{-1}$ and 2.2 fb$^{-1}$ of lepton+jets data, respectively. A direct measurement of the CKM matrix element that describes the $Wtb$ coupling is also performed for the first time., Comment: 4 pages

Published
2008

45. Search for Narrow-Width ttbar Resonances in ppbar Collisions at center of mass energy = 1.8 TeV

Author

Jain, Supriya, Mondal, Naba K., and Chakraborty, Dhiman

Subjects
High Energy Physics - Experiment
Abstract

We present a preliminary result on a search for narrow-width resonances that decay into ttbar pairs using 130 pb^{-1} of lepton plus jets data in ppbar collisions at center of mass energy = 1.8 TeV. No significant deviation from Standard Model prediction is observed. 95% C.L. upper limits on the production cross section of the narrow-width resonance times its branching fraction to ttbar are presented for different resonance masses, M_X. We also exclude the existence of a leptophobic topcolor particle, X, with M_X < 560 GeV/c^2 for a width \Gamma_X = 0.012 M_X., Comment: 3 pages, 1 figure; Submitted for proceedings of 5th International Conference on Quark Confinement and Hadron spectrum, held in Italy, from 11-14 Sep., 2002

Published
2003
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46. Search for Quark-Lepton Compositeness at Tevatron and LHC

Author

Jain, Supriya, Gupta, Ambreesh K., and Mondal, Naba K.

Subjects
High Energy Physics - Experiment
Abstract

We make a Monte Carlo study on compositeness of first generation quarks and leptons using the Drell-Yan distribution in the high dielectron mass region at the Tevatron and LHC energies. The current experimental lower limits on the compositeness scale, \Lambda, vary from 2.5 to 6.1 TeV. In the present analysis, we assume that there will be no deviation of the dielectron mass spectrum from Standard Model prediction at center of mass energy 2 TeV (Tevatron) and 14 TeV (LHC). We then find that in the LL, RR, RL and LR chirality channels of the quark-electron currents, it is possible to extend the lower limits on \Lambda (at 95% {CL}) to a range of 6 to 10 TeV for 2 fb^{-1} and 9 to 19 TeV for 30 fb^{-1} of integrated luminosity at Tevatron. At LHC, the corresponding limits extend to a range of 16 to 25 TeV for 10 fb^{-1} and 20 to 36 TeV for 100 fb^{-1} of integrated luminosity., Comment: 7 pages, 7 figures, 9 tables (Submitted to PR-D on May 10, 2000)

Published
2000
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47. Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry

Author

Harahsheh, Ashraf S., primary, Shah, Samay, additional, Dallaire, Frederic, additional, Manlhiot, Cedric, additional, Khoury, Michael, additional, Lee, Simon, additional, Fabi, Marianna, additional, Mauriello, Daniel, additional, Tierney, Elif Seda Selamet, additional, Sabati, Arash A., additional, Dionne, Audrey, additional, Dahdah, Nagib, additional, Choueiter, Nadine, additional, Thacker, Deepika, additional, Giglia, Therese M., additional, Truong, Dongngan T., additional, Jain, Supriya, additional, Portman, Michael, additional, Orr, William B., additional, Harris, Tyler H., additional, Szmuszkovicz, Jacqueline R., additional, Farid, Pedrom, additional, McCrindle, Brian W., additional, Alsalehi, Mahmoud, additional, Ballweg, Jean A., additional, Barnes, Benjamin, additional, Braunlin, Elizabeth, additional, Buffone, Ashley, additional, Bustamante-Ogando, Juan Carlos, additional, Chang, Arthur J., additional, Corral, Nicolas, additional, Dancey, Paul, additional, El-Ganzoury, Mona, additional, El-Samman, Nora, additional, Elias, Matthew, additional, Fernandez-Cooke, Elisa, additional, Friedman, Kevin, additional, Garrido-Garcia, Luis Martin, additional, Garrido, Luis Martin, additional, Goldenberg, Guillermo Larios, additional, Grcic, Michelle M., additional, Harris, Kevin C., additional, Hicar, Mark D., additional, Hindt, Bridgette, additional, Jone, Pei-Ni, additional, Kajimoto, Hidemi, additional, Kaneta, Kelli, additional, Khare, Manaswitha, additional, Knutson, Stacie, additional, Kutty, Shelby, additional, Lanari, Marcello, additional, Maksymiuk, Victoria, additional, McHugh, Kimberly E., additional, Merves, Shae, additional, Misra, Nilanjana, additional, Mohandas, Sindhu, additional, Mondal, Tapas, additional, Norozi, Kambiz, additional, Nowlen, Todd, additional, Pagano, Joseph J., additional, Prasad, Deepa, additional, Raghuveer, Geetha, additional, Ravi, Prasad, additional, Sundaram, Balasubramanian, additional, Sehgal, Anupam, additional, Shah, Ashish, additional, Vázquez, Belén Toral, additional, Tremoulet, Adriana H., additional, Venkataraman, Aishwarya, additional, Watelle, Laurence, additional, Yamazaki-Naksahimada, Marco Antonio, additional, and Yetman, Anji T., additional

Published
2023
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