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1. Global 30-day morbidity and mortality of surgery for perforated peptic ulcer: GRACE study

Author

Abouelazayem, Mohamed, Jain, Rajesh, Wilson, Michael S. J., Martinino, Alessandro, Balasubaramaniam, Vignesh, Biffl, Walter, Coccolini, Federico, Riera, Manel, Wadhawan, Himanshu, Wazir, Ishaan, Abderaouf, Bettahar, Abramov, Daniil, Abu Jayyab, Mustafa A., Al-Shami, Khayry, Alfarwan, Ahmad, Alhajami, Faris M., Alkaseek, Akram, Alozairi, Ous, Ammar, Ahmed Siddique, Atar, Burak, Baatarjav, Gan-Erdene, Bains, Lovenish, Bakri, Ashraf, Bayramov, Nuru, Bhojwani, Rajesh, Brachini, Gioia, Calini, Giacomo, Campanelli, Michela, Cheng, Shi Yu, Choudhary, Charan Singh, Chowdhury, Sharfuddin, Colak, Elif, Das, Jayanta Kumar, Dawani, Surrendar, Dönmez, Turgut, Elzayat, Ibrahim, Erdene, Sarnai, Faizi, Tashaba Qaiser, Frountzas, Maximos, Gafsi, Besma, Gentileschi, Paolo, Guler, Mert, Gupta, Gaurav, Harkati, Nour Elhouda, Harris, Matthew, Hasan, Doaa M., Irowa, Omorodion Omoruyi, Jafferi, Salman, Jain, Sumita Agarwal, Jun Han, Lai, Kandiboyina, Satyanarayana Murthy, Karabulut, Mehmetu, Khamees, Almu’atasim, Khan, Shahzeb, Khan, Madiha Masood, Khaw, Cheng Jing, Kisielewski, Michal, Klib, Mohamad, Košir, Jurij A., Krawczyk, Wiktor Jan, Lisi, Giorgio, Makama, Jerry Godfrey, Maqbool, Baila, Marques, Cláudia Neves, Meric, Serhat, Mietła, Mateusz Przemysław, Ads, Alaa Mohamed, Muhumuza, Joshua, Mulita, Francesk, Mustafayeva, Matanat, Omar, Mohammed A., Omarov, Taryel, Pathak, Akshant Anil, Paul, Ratnadeep, Pavone, Giovanna, Podda, Mauro, Raja Ram, Novinth Kumar, Rauf, Fatima, Rauf, Sidra, Safy, Ahmed Mohamed, Sandag, Erdene, Şanlı, Ahmet Necati, Siddiqui, Adeela Z., Sotiropoulou, Maria, Talib, Vikash, Tatar, Cihad, Thota, Anuroop, Tokocin, Merve, Tolat, Aditya, Uchikov, Petar Angelov, Valenzuela, José I., Venkatappa, Sunil Kumar, Verras, Georgios-Ioannis, Vlahović, Ivan, Zreeg, Dafer Abdulhakim S., Cardoso, Victor Roth, Gkoutos, Georgios V., Singhal, Rishi, and Mahawar, Kamal

Published
2024
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2. It is time to define an organizational model for the prevention and management of infections along the surgical pathway: a worldwide cross-sectional survey

Author

Sartelli, Massimo, Labricciosa, Francesco M., Coccolini, Federico, Coimbra, Raul, Abu-Zidan, Fikri M., Ansaloni, Luca, Al-Hasan, Majdi N., Ansari, Shamshul, Barie, Philip S., Caínzos, Miguel Angel, Ceresoli, Marco, Chiarugi, Massimo, Claridge, Jeffrey A., Cicuttin, Enrico, Dellinger, Evan Patchen, Fry, Donald E., Guirao, Xavier, Hardcastle, Timothy Craig, Hecker, Andreas, Leppäniemi, Ari K., Litvin, Andrey, Marwah, Sanjay, Maseda, Emilio, Mazuski, John E., Memish, Ziad Ahmed, Kirkpatrick, Andrew W., Pagani, Leonardo, Podda, Mauro, Rasa, Huseyin Kemal, Sakakushev, Boris E., Sawyer, Robert G., Tumietto, Fabio, Xiao, Yonghong, Aboubreeg, Wedad Faraj, Adamou, Harissou, Akhmeteli, Lali, Akin, Emrah, Alberio, Maria Grazia, Alconchel, Felipe, Magagi, Ibrahim Amadou, Araúz, Ana Belén, Argenio, Giulio, Atanasov, Boyko C., Atici, Semra Demirli, Awad, Selmy Sabry, Baili, Efstratia, Bains, Lovenish, Bala, Miklosh, Baraket, Oussama, Baral, Suman, Belskii, Vladislav A., Benboubker, Moussa, Ben-Ishay, Offir, Bordoni, Pierpaolo, Boumédiène, Abdalia, Brisinda, Giuseppe, Cavazzuti, Laura, Chandy, Sujith J., Chiarello, Maria Michela, Cillara, Nicola, Clarizia, Guglielmo, Cocuz, Maria-Elena, Cocuz, Iuliu Gabriel, Conti, Luigi, Coppola, Raffaella, Cui, Yunfeng, Czepiel, Jacek, D’Acapito, Fabrizio, Damaskos, Dimitrios, Das, Koray, De Simone, Belinda, Delibegovic, Samir, Demetrashvili, Zaza, Detanac, Dzemail S., Dhingra, Sameer, Di Bella, Stefano, Dimitrov, Evgeni N., Dogjani, Agron, D’Oria, Mario, Dumitru, Irina Magdalena, Elmangory, Mutasim M., Enciu, Octavian, Fantoni, Massimo, Filipescu, Daniela, Fleres, Francesco, Foghetti, Domitilla, Fransvea, Pietro, Gachabayov, Mahir, Galeiras, Rita, Gattuso, Gianni, Ghannam, Wagih M., Ghisetti, Valeria, Giraudo, Giorgio, Gonfa, Kebebe Bekele, Gonullu, Emre, Hamad, Yousif Tag Elsir Y., Hecker, Matthias, Isik, Arda, Ismail, Nizar, Ismail, Azzain, Jain, Sumita Agarwal, Kanj, Souha S., Kapoor, Garima, Karaiskos, Ilias, Kavalakat, Alfie J., Kenig, Jakub, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kim, Jae Il, Kobe, Yoshiro, Kok, Kenneth Yuh Yen, Kovacevic, Bojan M., Kryvoruchko, Igor Andreevich, Kuriyama, Akira, Landaluce-Olavarria, Aitor, Lasithiotakis, Konstantinos, Lohsiriwat, Varut, Lostoridis, Eftychios, Luppi, Davide, Vega, Gustavo Miguel Machain, Maegele, Marc, Marinis, Athanasios, Martines, Gennaro, Martínez-Pérez, Aleix, Massalou, Damien, Mesina, Cristian, Metan, Gökhan, Miranda-Novales, María Guadalupe, Mishra, Shyam Kumar, Mohamed, Mohaned Ibrahim Hussein, Mohamedahmed, Ali Yasen Y., Mora-Guzmán, Ismael, Mulita, Francesk, Musina, Ana-Maria, Navsaria, Pradeep H., Negoi, Ionut, Nita, Gabriela Elisa, O’Connor, Donal B., Ordoñez, Carlos Alberto, Pantalone, Desiré, Panyko, Arpád, Papadopoulos, Aristeidis, Pararas, Nikolaos, Pata, Francesco, Patel, Tapan, Pellino, Gianluca, Perra, Teresa, Perrone, Gennaro, Pesce, Antonio, Pintar, Tadeja, Popivanov, Georgi Ivanov, Porcu, Alberto, Quiodettis, Martha Alexa, Rahim, Razrim, Mitul, Ashrarur Rahman, Reichert, Martin, Rems, Miran, Campbell, Glendee Yolande Reynolds, Rocha-Pereira, Nuno, Rodrigues, Gabriel, Villamil, Gustavo Eduardo Roncancio, Rossi, Stefano, Sall, Ibrahima, Kafil, Hossein Samadi, Sasia, Diego, Seni, Jeremiah, Seretis, Charalampos, Serradilla-Martín, Mario, Shelat, Vishal G., Siribumrungwong, Boonying, Slavchev, Mihail, Solaini, Leonardo, Tan, Boun Kim, Tarasconi, Antonio, Tartaglia, Dario, Toma, Elena Adelina, Tomadze, Gia, Toro, Adriana, Tovani-Palone, Marcos Roberto, van Goor, Harry, Vasilescu, Alin, Vereczkei, Andras, Veroux, Massimiliano, Weckmann, Sergio Alberto, Widmer, Lukas Werner, Yahya, AliIbrahim, Zachariah, Sanoop K., Zakaria, Andee Dzulkarnaen, Zubareva, Nadezhda, Zuidema, Wietse P., Di Carlo, Isidoro, Cortese, Francesco, Baiocchi, Gian Luca, Maier, Ronald V., and Catena, Fausto

Published
2022
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3. A pandemic recap: lessons we have learned

Author

Coccolini, Federico, Cicuttin, Enrico, Cremonini, Camilla, Tartaglia, Dario, Viaggi, Bruno, Kuriyama, Akira, Picetti, Edoardo, Ball, Chad, Abu-Zidan, Fikri, Ceresoli, Marco, Turri, Bruno, Jain, Sumita, Palombo, Carlo, Guirao, Xavier, Rodrigues, Gabriel, Gachabayov, Mahir, Machado, Fernando, Eftychios, Lostoridis, Kanj, Souha S., Di Carlo, Isidoro, Di Saverio, Salomone, Khokha, Vladimir, Kirkpatrick, Andrew, Massalou, Damien, Forfori, Francesco, Corradi, Francesco, Delibegovic, Samir, Machain Vega, Gustavo M., Fantoni, Massimo, Demetriades, Demetrios, Kapoor, Garima, Kluger, Yoram, Ansari, Shamshul, Maier, Ron, Leppaniemi, Ari, Hardcastle, Timothy, Vereczkei, Andras, Karamagioli, Evika, Pikoulis, Emmanouil, Pistello, Mauro, Sakakushev, Boris E., Navsaria, Pradeep H., Galeiras, Rita, Yahya, Ali I., Osipov, Aleksei V., Dimitrov, Evgeni, Doklestić, Krstina, Pisano, Michele, Malacarne, Paolo, Carcoforo, Paolo, Sibilla, Maria Grazia, Kryvoruchko, Igor A., Bonavina, Luigi, Kim, Jae Il, Shelat, Vishal G., Czepiel, Jacek, Maseda, Emilio, Marwah, Sanjay, Chirica, Mircea, Biancofiore, Giandomenico, Podda, Mauro, Cobianchi, Lorenzo, Ansaloni, Luca, Fugazzola, Paola, Seretis, Charalampos, Gomez, Carlos Augusto, Tumietto, Fabio, Malbrain, Manu, Reichert, Martin, Augustin, Goran, Amato, Bruno, Puzziello, Alessandro, Hecker, Andreas, Gemignani, Angelo, Isik, Arda, Cucchetti, Alessandro, Nacoti, Mirco, Kopelman, Doron, Mesina, Cristian, Ghannam, Wagih, Ben-Ishay, Offir, Dhingra, Sameer, Coimbra, Raul, Moore, Ernest E., Cui, Yunfeng, Quiodettis, Martha A., Bala, Miklosh, Testini, Mario, Diaz, Jose, Girardis, Massimo, Biffl, Walter L., Hecker, Matthias, Sall, Ibrahima, Boggi, Ugo, Materazzi, Gabriele, Ghiadoni, Lorenzo, Matsumoto, Junichi, Zuidema, Wietse P., Ivatury, Rao, Enani, Mushira A., Litvin, Andrey, Al-Hasan, Majdi N., Demetrashvili, Zaza, Baraket, Oussama, Ordoñez, Carlos A., Negoi, Ionut, Kiguba, Ronald, Memish, Ziad A., Elmangory, Mutasim M., Tolonen, Matti, Das, Korey, Ribeiro, Julival, O’Connor, Donal B., Tan, Boun Kim, Van Goor, Harry, Baral, Suman, De Simone, Belinda, Corbella, Davide, Brambillasca, Pietro, Scaglione, Michelangelo, Basolo, Fulvio, De’Angelis, Nicola, Bendinelli, Cino, Weber, Dieter, Pagani, Leonardo, Monti, Cinzia, Baiocchi, Gianluca, Chiarugi, Massimo, Catena, Fausto, and Sartelli, Massimo

Published
2021
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4. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study

Author

Sartelli, Massimo, Abu-Zidan, Fikri M., Labricciosa, Francesco M., Kluger, Yoram, Coccolini, Federico, Ansaloni, Luca, Leppäniemi, Ari, Kirkpatrick, Andrew W., Tolonen, Matti, Tranà, Cristian, Regimbeau, Jean-Marc, Hardcastle, Timothy, Koshy, Renol M., Abbas, Ashraf, Aday, Ulaş, Adesunkanmi, A. R. K., Ajibade, Adesina, Akhmeteli, Lali, Akın, Emrah, Akkapulu, Nezih, Alotaibi, Alhenouf, Altintoprak, Fatih, Anyfantakis, Dimitrios, Atanasov, Boyko, Augustin, Goran, Azevedo, Constança, Bala, Miklosh, Balalis, Dimitrios, Baraket, Oussama, Baral, Suman, Barkai, Or, Beltran, Marcelo, Bini, Roberto, Bouliaris, Konstantinos, Caballero, Ana B., Calu, Valentin, Catani, Marco, Ceresoli, Marco, Charalampakis, Vasileios, Jusoh, Asri Che, Chiarugi, Massimo, Cillara, Nicola, Cuesta, Raquel Cobos, Cobuccio, Luigi, Cocorullo, Gianfranco, Colak, Elif, Conti, Luigi, Cui, Yunfeng, De Simone, Belinda, Delibegovic, Samir, Demetrashvili, Zaza, Demetriades, Demetrios, Dimova, Ana, Dogjani, Agron, Enani, Mushira, Farina, Federica, Ferrara, Francesco, Foghetti, Domitilla, Fontana, Tommaso, Fraga, Gustavo P., Gachabayov, Mahir, Gérard, Grelpois, Ghnnam, Wagih, Maurel, Teresa Giménez, Gkiokas, Georgios, Gomes, Carlos A., Guner, Ali, Gupta, Sanjay, Hecker, Andreas, Hirano, Elcio S., Hodonou, Adrien, Hutan, Martin, Ilaschuk, Igor, Ioannidis, Orestis, Isik, Arda, Ivakhov, Georgy, Jain, Sumita, Jokubauskas, Mantas, Karamarkovic, Aleksandar, Kaushik, Robin, Kenig, Jakub, Khokha, Vladimir, Khokha, Denis, Kim, Jae Il, Kong, Victor, Korkolis, Dimitris, Kruger, Vitor F., Kshirsagar, Ashok, Simões, Romeo Lages, Lanaia, Andrea, Lasithiotakis, Konstantinos, Leão, Pedro, Arellano, Miguel León, Listle, Holger, Litvin, Andrey, Lizarazu Pérez, Aintzane, Lopez-Tomassetti Fernandez, Eudaldo, Lostoridis, Eftychios, Luppi, Davide, Machain V, Gustavo M., Major, Piotr, Manatakis, Dimitrios, Reitz, Marianne Marchini, Marinis, Athanasios, Marrelli, Daniele, Martínez-Pérez, Aleix, Marwah, Sanjay, McFarlane, Michael, Mesic, Mirza, Mesina, Cristian, Michalopoulos, Nickos, Misiakos, Evangelos, Moreira, Felipe Gonçalves, Mouaqit, Ouadii, Muhtaroglu, Ali, Naidoo, Noel, Negoi, Ionut, Nikitina, Zane, Nikolopoulos, Ioannis, Nita, Gabriela-Elisa, Occhionorelli, Savino, Olaoye, Iyiade, Ordoñez, Carlos A., Ozkan, Zeynep, Pal, Ajay, Palini, Gian M., Papageorgiou, Kyriaki, Papagoras, Dimitris, Pata, Francesco, Pędziwiatr, Michał, Pereira, Jorge, Pereira Junior, Gerson A., Perrone, Gennaro, Pintar, Tadeja, Pisarska, Magdalena, Plehutsa, Oleksandr, Podda, Mauro, Poillucci, Gaetano, Quiodettis, Martha, Rahim, Tuba, Rios-Cruz, Daniel, Rodrigues, Gabriel, Rozov, Dmytry, Sakakushev, Boris, Sall, Ibrahima, Sazhin, Alexander, Semião, Miguel, Sharda, Taanya, Shelat, Vishal, Sinibaldi, Giovanni, Skicko, Dmitrijs, Skrovina, Matej, Stamatiou, Dimitrios, Stella, Marco, Strzałka, Marcin, Sydorchuk, Ruslan, Teixeira Gonsaga, Ricardo A., Tochie, Joel Noutakdie, Tomadze, Gia, Ugoletti, Lara, Ulrych, Jan, Ümarik, Toomas, Uzunoglu, Mustafa Y., Vasilescu, Alin, Vaz, Osborne, Vereczkei, Andras, Vlad, Nutu, Walędziak, Maciej, Yahya, Ali I., Yalkin, Omer, Yilmaz, Tonguç U., Ünal, Ali Ekrem, Yuan, Kuo-Ching, Zachariah, Sanoop K., Žilinskas, Justas, Zizzo, Maurizio, Pattonieri, Vittoria, Baiocchi, Gian Luca, and Catena, Fausto

Published
2019
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5. Prospective Observational Study on acute Appendicitis Worldwide (POSAW)

Author

Sartelli, Massimo, Baiocchi, Gian L., Di Saverio, Salomone, Ferrara, Francesco, Labricciosa, Francesco M., Ansaloni, Luca, Coccolini, Federico, Vijayan, Deepak, Abbas, Ashraf, Abongwa, Hariscine K., Agboola, John, Ahmed, Adamu, Akhmeteli, Lali, Akkapulu, Nezih, Akkucuk, Seckin, Altintoprak, Fatih, Andreiev, Aurelia L., Anyfantakis, Dimitrios, Atanasov, Boiko, Bala, Miklosh, Balalis, Dimitrios, Baraket, Oussama, Bellanova, Giovanni, Beltran, Marcelo, Melo, Renato Bessa, Bini, Roberto, Bouliaris, Konstantinos, Brunelli, Daniele, Castillo, Adrian, Catani, Marco, Che Jusoh, Asri, Chichom-Mefire, Alain, Cocorullo, Gianfranco, Coimbra, Raul, Colak, Elif, Costa, Silvia, Das, Koray, Delibegovic, Samir, Demetrashvili, Zaza, Di Carlo, Isidoro, Kiseleva, Nadezda, El Zalabany, Tamer, Faro, Mario, Ferreira, Margarida, Fraga, Gustavo P., Gachabayov, Mahir, Ghnnam, Wagih M., Giménez Maurel, Teresa, Gkiokas, Georgios, Gomes, Carlos A., Griffiths, Ewen, Guner, Ali, Gupta, Sanjay, Hecker, Andreas, Hirano, Elcio S., Hodonou, Adrien, Hutan, Martin, Ioannidis, Orestis, Isik, Arda, Ivakhov, Georgy, Jain, Sumita, Jokubauskas, Mantas, Karamarkovic, Aleksandar, Kauhanen, Saila, Kaushik, Robin, Kavalakat, Alfie, Kenig, Jakub, Khokha, Vladimir, Khor, Desmond, Kim, Dennis, Kim, Jae I., Kong, Victor, Lasithiotakis, Konstantinos, Leão, Pedro, Leon, Miguel, Litvin, Andrey, Lohsiriwat, Varut, López-Tomassetti Fernandez, Eudaldo, Lostoridis, Eftychios, Maciel, James, Major, Piotr, Dimova, Ana, Manatakis, Dimitrios, Marinis, Athanasio, Martinez-Perez, Aleix, Marwah, Sanjay, McFarlane, Michael, Mesina, Cristian, Pędziwiatr, Michał, Michalopoulos, Nickos, Misiakos, Evangelos, Mohamedahmed, Ali, Moldovanu, Radu, Montori, Giulia, Mysore Narayana, Raghuveer, Negoi, Ionut, Nikolopoulos, Ioannis, Novelli, Giuseppe, Novikovs, Viktors, Olaoye, Iyiade, Omari, Abdelkarim, Ordoñez, Carlos A., Ouadii, Mouaqit, Ozkan, Zeynep, Pal, Ajay, Palini, Gian M., Partecke, Lars I., Pata, Francesco, Pędziwiatr, Michał, Pereira Júnior, Gerson A., Pintar, Tadeja, Pisarska, Magdalena, Ploneda-Valencia, Cesar F., Pouggouras, Konstantinos, Prabhu, Vinod, Ramakrishnapillai, Padmakumar, Regimbeau, Jean-Marc, Reitz, Marianne, Rios-Cruz, Daniel, Saar, Sten, Sakakushev, Boris, Seretis, Charalampos, Sazhin, Alexander, Shelat, Vishal, Skrovina, Matej, Smirnov, Dmitry, Spyropoulos, Charalampos, Strzałka, Marcin, Talving, Peep, Teixeira Gonsaga, Ricardo A., Theobald, George, Tomadze, Gia, Torba, Myftar, Tranà, Cristian, Ulrych, Jan, Uzunoğlu, Mustafa Y., Vasilescu, Alin, Occhionorelli, Savino, Venara, Aurélien, Vereczkei, Andras, Vettoretto, Nereo, Vlad, Nutu, Walędziak, Maciej, Yilmaz, Tonguç U., Yuan, Kuo-Ching, Yunfeng, Cui, Zilinskas, Justas, Grelpois, Gérard, and Catena, Fausto

Published
2018
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7. Additional file 1 of It is time to define an organizational model for the prevention and management of infections along the surgical pathway: a worldwide cross-sectional survey

Author

Sartelli, Massimo, Labricciosa, Francesco M., Coccolini, Federico, Coimbra, Raul, Abu-Zidan, Fikri M., Ansaloni, Luca, Al-Hasan, Majdi N., Ansari, Shamshul, Barie, Philip S., Ca��nzos, Miguel Angel, Ceresoli, Marco, Chiarugi, Massimo, Claridge, Jeffrey A., Cicuttin, Enrico, Dellinger, Evan Patchen, Fry, Donald E., Guirao, Xavier, Hardcastle, Timothy Craig, Hecker, Andreas, Lepp��niemi, Ari K., Litvin, Andrey, Marwah, Sanjay, Maseda, Emilio, Mazuski, John E., Memish, Ziad Ahmed, Kirkpatrick, Andrew W., Pagani, Leonardo, Podda, Mauro, Rasa, Huseyin Kemal, Sakakushev, Boris E., Sawyer, Robert G., Tumietto, Fabio, Xiao, Yonghong, Aboubreeg, Wedad Faraj, Adamou, Harissou, Akhmeteli, Lali, Akin, Emrah, Alberio, Maria Grazia, Alconchel, Felipe, Magagi, Ibrahim Amadou, Ara��z, Ana Bel��n, Argenio, Giulio, Atanasov, Boyko C., Atici, Semra Demirli, Awad, Selmy Sabry, Baili, Efstratia, Bains, Lovenish, Bala, Miklosh, Baraket, Oussama, Baral, Suman, Belskii, Vladislav A., Benboubker, Moussa, Ben-Ishay, Offir, Bordoni, Pierpaolo, Boum��di��ne, Abdalia, Brisinda, Giuseppe, Cavazzuti, Laura, Chandy, Sujith J., Chiarello, Maria Michela, Cillara, Nicola, Clarizia, Guglielmo, Cocuz, Maria-Elena, Cocuz, Iuliu Gabriel, Conti, Luigi, Coppola, Raffaella, Cui, Yunfeng, Czepiel, Jacek, D���Acapito, Fabrizio, Damaskos, Dimitrios, Das, Koray, De Simone, Belinda, Delibegovic, Samir, Demetrashvili, Zaza, Detanac, Dzemail S., Dhingra, Sameer, Di Bella, Stefano, Dimitrov, Evgeni N., Dogjani, Agron, D���Oria, Mario, Dumitru, Irina Magdalena, Elmangory, Mutasim M., Enciu, Octavian, Fantoni, Massimo, Filipescu, Daniela, Fleres, Francesco, Foghetti, Domitilla, Fransvea, Pietro, Gachabayov, Mahir, Galeiras, Rita, Gattuso, Gianni, Ghannam, Wagih M., Ghisetti, Valeria, Giraudo, Giorgio, Gonfa, Kebebe Bekele, Gonullu, Emre, Hamad, Yousif Tag Elsir Y., Hecker, Matthias, Isik, Arda, Ismail, Nizar, Ismail, Azzain, Jain, Sumita Agarwal, Kanj, Souha S., Kapoor, Garima, Karaiskos, Ilias, Kavalakat, Alfie J., Kenig, Jakub, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kim, Jae Il, Kobe, Yoshiro, Kok, Kenneth Yuh Yen, Kovacevic, Bojan M., Kryvoruchko, Igor Andreevich, Kuriyama, Akira, Landaluce-Olavarria, Aitor, Lasithiotakis, Konstantinos, Lohsiriwat, Varut, Lostoridis, Eftychios, Luppi, Davide, Vega, Gustavo Miguel Machain, Maegele, Marc, Marinis, Athanasios, Martines, Gennaro, Mart��nez-P��rez, Aleix, Massalou, Damien, Mesina, Cristian, Metan, G��khan, Miranda-Novales, Mar��a Guadalupe, Mishra, Shyam Kumar, Mohamed, Mohaned Ibrahim Hussein, Mohamedahmed, Ali Yasen Y., Mora-Guzm��n, Ismael, Mulita, Francesk, Musina, Ana-Maria, Navsaria, Pradeep H., Negoi, Ionut, Nita, Gabriela Elisa, O���Connor, Donal B., Ordo��ez, Carlos Alberto, Pantalone, Desir��, Panyko, Arp��d, Papadopoulos, Aristeidis, Pararas, Nikolaos, Pata, Francesco, Patel, Tapan, Pellino, Gianluca, Perra, Teresa, Perrone, Gennaro, Pesce, Antonio, Pintar, Tadeja, Popivanov, Georgi Ivanov, Porcu, Alberto, Quiodettis, Martha Alexa, Rahim, Razrim, Mitul, Ashrarur Rahman, Reichert, Martin, Rems, Miran, Campbell, Glendee Yolande Reynolds, Rocha-Pereira, Nuno, Rodrigues, Gabriel, Villamil, Gustavo Eduardo Roncancio, Rossi, Stefano, Sall, Ibrahima, Kafil, Hossein Samadi, Sasia, Diego, Seni, Jeremiah, Seretis, Charalampos, Serradilla-Mart��n, Mario, Shelat, Vishal G., Siribumrungwong, Boonying, Slavchev, Mihail, Solaini, Leonardo, Tan, Boun Kim, Tarasconi, Antonio, Tartaglia, Dario, Toma, Elena Adelina, Tomadze, Gia, Toro, Adriana, Tovani-Palone, Marcos Roberto, van Goor, Harry, Vasilescu, Alin, Vereczkei, Andras, Veroux, Massimiliano, Weckmann, Sergio Alberto, Widmer, Lukas Werner, Yahya, AliIbrahim, Zachariah, Sanoop K., Zakaria, Andee Dzulkarnaen, Zubareva, Nadezhda, Zuidema, Wietse P., Di Carlo, Isidoro, Cortese, Francesco, Baiocchi, Gian Luca, Maier, Ronald V., and Catena, Fausto

Abstract

Additional file 1. Questionnaire.

Published
2022
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8. Correction to: Two years later: Is the SARS-CoV-2 pandemic still having an impact on emergency surgery? An international cross-sectional survey among WSES members

Author

Reichert, Martin, Sartelli, Massimo, Weigand, Markus A., Hecker, Matthias, Oppelt, Philip U., Noll, Julia, Askevold, Ingolf H., Liese, Juliane, Padberg, Winfried, Coccolini, Federico, Catena, Fausto, Hecker, Andreas, Peckham-Cooper, Adam, Camacho-Ortiz, Adrian, Mastoraki, Aikaterini T., Landaluce-Olavarria, Aitor, Pal, Ajay Kumar, Kuriyama, Akira, Chichom-Mefire, Alain, Porcu, Alberto, Martínez-Pérez, Aleix, Karamarkovic, Aleksandar R., Osipov, Aleksei V., Coppola, Alessandro, Cucchetti, Alessandro, Spolini, Alessandro, Giordano, Alessio, Reinisch-Liese, Alexander, Kavalakat, Alfie J., Vasilescu, Alin, Alamin, Amin, Gupta, Amit, Dascalu, Ana Maria, Musina, Ana-Maria, Bakopoulos, Anargyros, Zakaria, Andee Dzulkarnaen, Vereczkei, Andras, Balla, Andrea, Bottari, Andrea, Baumann, Andreas, Fette, Andreas, Litvin, Andrey, Reichert, Aniella Katharina, Guariniello, Anna, Paspala, Anna, Schneck, Anne-Sophie, Brillantino, Antonio, Pesce, Antonio, Isik, Arda, Leppäniemi, Ari Kalevi, Papadopoulos, Aristeidis, Kechagias, Aristotelis, Mohamed, Ashraf Yehya Abdalla, Mitul, Ashrarur Rahman, Marinis, Athanasios, Syllaios, Athanasios, Mantoglu, Baris, De Simone, Belinda, Weiss, Benjamin Stefan, Pösentrup, Bernd, Picardi, Biagio, Zampogna, Biagio, Sakakushev, Boris Eugeniev, Atanasov, Boyko Chavdarov, Nardo, Bruno, Calik, Bulent, Cremonini, Camilla, Ordoñez, Carlos A., Seretis, Charalampos, Cascone, Chiara, Chouliaras, Christos, Bendinelli, Cino, Lopes, Claudia, Guerci, Claudio, Weber, Clemens, Nastos, Constantinos, Mesina, Cristian, Caputo, Damiano, Massalou, Damien, Cavaliere, Davide, Mcnamara, Deborah A., Demetriades, Demetrios, Pantalone, Desirè, Coletta, Diego, Sasia, Diego, Visconti, Diego, Weber, Dieter G., Corallino, Diletta, Chatzipetris, Dimitrios, Manatakis, Dimitrios K., Ntourakis, Dimitrios, Papaconstantinou, Dimitrios, Schizas, Dimitrios, Chrysikos, Dimosthenis, Adamovich, Dmitry Mikhailovich, Elkafrawy, Doaa, Seban, Dragos, García, Edgar Fernando Hernandez, Baldini, Edoardo, Picetti, Edoardo, Tan, Edward C. T. H., Baili, Efstratia, Lostoridis, Eftychios, Toma, Elena Adelina, Colak, Elif, Cerutti, Elisabetta, Steyn, Elmin, Hsabo, Elmuiz A., Kapetanakis, Emmanouil Ioannis, Kaouras, Emmanouil, Schneck, Emmanuel, Akin, Emrah, Gonullu, Emre, Çelik, Enes, Cicuttin, Enrico, Pinotti, Enrico, Johnsson, Erik, Moore, Ernest E., Agastra, Ervis, Dimitrov, Evgeni Nikolaev, Griffiths, Ewen A., D’Acapito, Fabrizio, Saraceno, Federica, Alconchel, Felipe, Zeppernick, Felix Alexander, Rodríguez, Fernando Machado, Abu-Zidan, Fikri, Pecchini, Francesca, Favi, Francesco, Ferrara, Francesco, Fleres, Francesco, Pata, Francesco, Roscio, Francesco Pietro Maria, Mulita, Francesk, Dor, Frank J. M. F., Linder, Fredrik, Dimofte, Gabriel, Rodrigues, Gabriel, Nita, Gabriela, Sganga, Gabriele, Martines, Gennaro, Mazzarella, Gennaro, Perrone, Gennaro, Velmahos, George, Lianos, Georgios D., Tomadze, Gia, Baiocchi, Gian Luca, D’Ambrosio, Giancarlo, Pellino, Gianluca, Pattacini, Gianmaria Casoni, Giraudo, Giorgio, Lisi, Giorgio, Tebala, Giovanni Domenico, Pirozzolo, Giovanni, Montori, Giulia, Argenio, Giulio, Brisinda, Giuseppe, Currò, Giuseppe, Giuliani, Giuseppe, Palomba, Giuseppe, Roscitano, Giuseppe, Avşar, Gökhan, Augustin, Goran, Clarizia, Guglielmo, Vega, Gustavo M. Machain, Fraga, Gustavo P., Sethi, Harsheet, Eltyeb, Hazim Abdulnassir, Lohse, Helmut A. Segovia, Lohse, Herald René Segovia, Bayhan, Hüseyin, Hamid, Hytham K. S., Kryvoruchko, Igor A., Iannone, Immacolata, Wani, Imtiaz, Lazaridis, Ioannis I., Katsaros, Ioannis, Nikolopoulos, Ioannis, Negoi, Ionut, Reccia, Isabella, Di Carlo, Isidoro, Olaoye, Iyiade Olatunde, Czepiel, Jacek, Kim, Jae Il, Meyer, Jeremy, Terrazas, Jesus Manuel Saenz, Tochie, Joel Noutakdie, Galante, Joseph M., Davies, Justin, Sugand, Kapil, Gonfa, Kebebe Bekele, Rasa, Kemal, Kok, Kenneth Y. Y., Apostolou, Konstantinos G., Lasithiotakis, Konstantinos, Tsekouras, Konstantinos, Angamuthu, Kumar, Akhmeteli, Lali, Sydorchuk, Larysa, Fortuna, Laura, Siragusa, Leandro, Pagani, Leonardo, Solaini, Leonardo, Miller, Lisa A., Bains, Lovenish, Ansaloni, Luca, Ferrario, Luca, Bonavina, Luigi, Conti, Luigi, Buonomo, Luis Antonio, Tallon-Aguilar, Luis, Tomczyk, Lukas, Widmer, Lukas Werner, Walędziak, Maciej, Gachabayov, Mahir, Bulanauca, Maloni M., Malbrain, Manu L. N. G., Maegele, Marc, Catarci, Marco, Ceresoli, Marco, Ranucci, Maria Chiara, Antonopoulou, Maria Ioanna, Papadoliopoulou, Maria, Valenti, Maria Rosaria, Sotiropoulou, Maria, D’Oria, Mario, Martín, Mario Serradilla, Hirschburger, Markus, Veroux, Massimiliano, Fantoni, Massimo, Nardi, Matteo, Tolonen, Matti, Montuori, Mauro, Podda, Mauro, Scheiterle, Maximilian, Frountzas, Maximos, Sarıkaya, Mehmet, Yildirim, Mehmet, Bender, Michael, Vailas, Michail, Teuben, Michel, Campanelli, Michela, Ammendola, Michele, Malerba, Michele, Pisano, Michele, Pertea, Mihaela, Slavchev, Mihail, Ukkonen, Mika, Bala, Miklosh, Chirica, Mircea, Barone, Mirko, Shaat, Mohamed Maher, Mohammed, Mohammed Jibreel Suliman, Abuelgasim, Mona Awad Akasha, Gureh, Monika, Ouadii, Mouaqit, Balkan, Mujdat, Mohamed, Mumin, Hakseven, Musluh, Velenciuc, Natalia, Cillara, Nicola, De’Angelis, Nicola, Tamini, Nicolò, Zavras, Nikolaos J., Machairas, Nikolaos, Michalopoulos, Nikolaos, Koliakos, Nikolaos N., Pararas, Nikolaos, Donlon, Noel E., Medappil, Noushif, Ben-Ishay, Offir, Stefano, Olmi, Islam, Omar, Tammo, Ömer, Ioannidis, Orestis, Aparicio, Oscar, Baraket, Oussama, Kumar, Pankaj, Cianci, Pasquale, Örtenwall, Per, Uchikov, Petar Angelov, de Reuver, Philip, Stahel, Philip F., Barie, Philip S., Piccoli, Micaela, Major, Piotr, Navsaria, Pradeep H., Sasmal, Prakash Kumar, Coimbra, Raul, Rahim, Razrim, Çapoğlu, Recayi, Koshy, Renol M., Gonsaga, Ricardo Alessandro Teixeira, Pertile, Riccardo, Mohamed, Rifat Ramadan Mussa, Deryol, Rıza, Sawyer, Robert G., Angelico, Roberta, Ragozzino, Roberta, Bini, Roberto, Cammarata, Roberto, Scaramuzzo, Rosa, Gioco, Rossella, Sydorchuk, Ruslan, Ahmed, Salma, Di Saverio, Salomone, Emile, Sameh Hany, Delibegovic, Samir, Marwah, Sanjay, Symeonidis, Savvas, Thomas, Scott G., Demir, Sebahattin, Awad, Selmy S., Atici, Semra Demirli, Chooklin, Serge, Meric, Serhat, Sarıkaya, Sevcan, Chowdhury, Sharfuddin, Mirghani, Shaza Faycal, Wren, Sherry M., Gargarella, Simone, Del Monte, Simone Rossi, Esposito, Sofia, Xenaki, Sofia, Mohamed, Soliman Fayez Ghedan, Beka, Solomon Gurmu, Lunca, Sorinel, Delis, Spiros G., Dritsas, Spyridon, Morarasu, Stefan, Magnone, Stefano, Rossi, Stefano, Bitsianis, Stefanos, Kykalos, Stylianos, Baral, Suman, Jain, Sumita A., Ali, Syed Muhammad, Pintar, Tadeja, Triantafyllou, Tania, Delko, Tarik, Perra, Teresa, Sidiropoulos, Theodoros A., Scalea, Thomas M., Vilz, Tim Oliver, Hardcastle, Timothy Craig, Wannatoop, Tongporn, Herzog, Torsten, Mishra, Tushar Subhadarshan, Boggi, Ugo, Calu, Valentin, Tomajer, Valentina, Agnoletti, Vanni, Lohsiriwat, Varut, Kong, Victor, Muñoz-Cruzado, Virginia Durán, Shelat, Vishal G., Khokha, Vladimir, Ghannam, Wagih Mommtaz, Biffl, Walter L., Zuidema, Wietse, Kara, Yasin, Kobe, Yoshiro, Demetrashvili, Zaza, Memish, Ziad A., Madrazo, Zoilo, Balogh, Zsolt J., and Bayhan, Zulfu

Subjects
Emergency Medicine, Surgery
Published
2022

10. Genomic and functional characterization of a mucosal symbiont involved in early-stage colorectal cancer

Author

Kordahi, Melissa C., primary, Stanaway, Ian B., additional, Avril, Marion, additional, Chac, Denise, additional, Blanc, Marie-Pierre, additional, Ross, Benjamin, additional, Diener, Christian, additional, Jain, Sumita, additional, McCleary, Paul, additional, Parker, Anika, additional, Friedman, Vincent, additional, Huang, Jennifer, additional, Burke, Wynn, additional, Gibbons, Sean M., additional, Willis, Amy D., additional, Darveau, Richard P., additional, Grady, William M., additional, Ko, Cynthia W., additional, and DePaolo, R. William, additional

Published
2021
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12. A pandemic recap: lessons we have learned

Author

Coccolini, Federico Cicuttin, Enrico Cremonini, Camilla and Tartaglia, Dario Viaggi, Bruno Kuriyama, Akira Picetti, Edoardo Ball, Chad Abu-Zidan, Fikri Ceresoli, Marco and Turri, Bruno Jain, Sumita Palombo, Carlo Guirao, Xavier and Rodrigues, Gabriel Gachabayov, Mahir Machado, Fernando and Eftychios, Lostoridis Kanj, Souha S. Di Carlo, Isidoro Di Saverio, Salomone Khokha, Vladimir Kirkpatrick, Andrew and Massalou, Damien Forfori, Francesco Corradi, Francesco and Delibegovic, Samir Machain Vega, Gustavo M. Fantoni, Massimo and Demetriades, Demetrios Kapoor, Garima Kluger, Yoram Ansari, Shamshul Maier, Ron Leppaniemi, Ari Hardcastle, Timothy and Vereczkei, Andras Karamagioli, Evika Pikoulis, Emmanouil and Pistello, Mauro Sakakushev, Boris E. Navsaria, Pradeep H. and Galeiras, Rita Yahya, Ali I. Osipov, Aleksei V. Dimitrov, Evgeni Doklestic, Krstina Pisano, Michele Malacarne, Paolo and Carcoforo, Paolo Sibilla, Maria Grazia Kryvoruchko, Igor A. and Bonavina, Luigi Kim, Jae Il Shelat, Vishal G. Czepiel, Jacek Maseda, Emilio Marwah, Sanjay Chirica, Mircea and Biancofiore, Giandomenico Podda, Mauro Cobianchi, Lorenzo and Ansaloni, Luca Fugazzola, Paola Seretis, Charalampos Gomez, Carlos Augusto Tumietto, Fabio Malbrain, Manu Reichert, Martin Augustin, Goran Amato, Bruno Puzziello, Alessandro and Hecker, Andreas Gemignani, Angelo Isik, Arda Cucchetti, Alessandro Nacoti, Mirco Kopelman, Doron Mesina, Cristian and Ghannam, Wagih Ben-Ishay, Offir Dhingra, Sameer Coimbra, Raul Moore, Ernest E. Cui, Yunfeng Quiodettis, Martha A. and Bala, Miklosh Testini, Mario Diaz, Jose Girardis, Massimo and Biffl, Walter L. Hecker, Matthias Sall, Ibrahima Boggi, Ugo Materazzi, Gabriele Ghiadoni, Lorenzo Matsumoto, Junichi and Zuidema, Wietse P. Ivatury, Rao Enani, Mushira A. and Litvin, Andrey Al-Hasan, Majdi N. Demetrashvili, Zaza and Baraket, Oussama Ordonez, Carlos A. Negoi, Ionut Kiguba, Ronald Memish, Ziad A. Elmangory, Mutasim M. Tolonen, Matti and Das, Korey Ribeiro, Julival O'Connor, Donal B. Tan, Boun Kim Van Goor, Harry Baral, Suman De Simone, Belinda and Corbella, Davide Brambillasca, Pietro Scaglione, Michelangelo and Basolo, Fulvio De'Angelis, Nicola Bendinelli, Cino and Weber, Dieter Pagani, Leonardo Monti, Cinzia Baiocchi, Gianluca Chiarugi, Massimo Catena, Fausto Sartelli, Massimo

Abstract

On January 2020, the WHO Director General declared that the outbreak constitutes a Public Health Emergency of International Concern. The world has faced a worldwide spread crisis and is still dealing with it. The present paper represents a white paper concerning the tough lessons we have learned from the COVID-19 pandemic. Thus, an international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making. With the present paper, international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making.

Published
2021

13. Contribution of the periplasmic chaperone Skp to efficient presentation of the autotransporter IcsA on the surface of Shigella flexneri

Author

Wagner, Jennifer K., Heindl, Jason E., Gray, Andrew N., Jain, Sumita, and Goldberg, Marcia B.

Subjects
Shigella flexneri -- Physiological aspects, Shigella flexneri -- Genetic aspects, Periplasm -- Properties, Bacterial proteins -- Properties, Molecular chaperones -- Physiological aspects, Biological sciences
Abstract

IcsA is an outer membrane protein in the autotransporter family that is required for Shigella flexneri pathogenesis. Following its secretion through the Sec translocon, IcsA is incorporated into the outer membrane in a process that depends on YaeT, a component of an outer membrane [beta]-barrel insertion machinery. We investigated the role of the periplasmic chaperone Skp in IcsA maturation. Skp is required for the presentation of the mature amino terminus (alpha-domain) of IcsA on the bacterial surface and contributes to cell-to-cell spread of S. flexneri in cell culture. A mutation in skp does not prevent the insertion of the [beta]-barrel into the outer membrane, suggesting that the primary role of Skp is the folding of the IcsA alpha-domain. In addition, the requirement for skp can be partially bypassed by disrupting icsP, an ortholog of Escherichia coli ompT, which encodes the protease that processes IcsA between the mature amino terminus and the [beta]-barrel outer membrane anchor. These findings are consistent with a model in which Skp plays a critical role in the chaperoning of the alpha-domain of IcsA during transit through the periplasm.

Published
2009

15. Membrane topology and roles of Pseudomonas aeruginosa Alg8 and Alg44 in alginate polymerization

Author

Oglesby, Lashanda L., Jain, Sumita, and Ohman, Dennis E.

Subjects
Pseudomonas aeruginosa -- Health aspects, Pseudomonas aeruginosa -- Physiological aspects, Cell membranes -- Research, Biological sciences
Abstract

Mucoid strains of Pseudomonas aeruginosa that overproduce alginate are associated with chronic pulmonary disease (e.g. cystic fibrosis). Mutants defective in one of several periplasmic proteins (AlgKGX) for alginate secretion release alginate fragments due to the activity of an alginate lyase (AlgL) in the periplasm, which cleaves the newly formed polymers. However, mutants defective in Alg8 or Alg44 did not secrete polymer or alginate fragments, suggesting that both these membrane proteins have a role in the polymerization reaction. A model for the membrane topology of Alg8, a glycosyltransferase (GT), was constructed using PhoA fusions. This provided evidence for a large cytoplasmic loop containing the active domains predicted for [beta]-GTs such as Alg8 and five transmembrane (TM) domains, one of which resembles a cleavable signal peptide. The C-terminal TM domain of Alg8 was critical for the polymerization reaction in vivo. Alanine substitution mutagenesis showed that all of the predicted active site residues in the widely spaced D, DxD, D, LxxRW motif were required for polymerization activity in vivo, and two of these substitutions also affected Alg8 protein stability. A membrane topology model for Alg44 was also constructed using PhoA fusions, and this showed a central TM domain and predicted an N-terminal TM domain that may be a membrane anchor. An N-terminal PilZ domain in Alg44 for cdi-GMP [bis-(3',5')-cyclic dimeric GMP] binding, which is required for alginate synthesis, was localized to the cytoplasmic loop. The long periplasmic C terminus of Alg44 contains a region similar to membrane fusion proteins (MFPs) of multi-drug efflux systems, which predicts the possibility of its interaction with another protein in this compartment. A Western blot analysis of the outer-membrane porin AlgE showed reduced AlgE levels in the alg44 mutant, whereas expression of Alg44 in trans restored AlgE within the cell. C-terminal truncations of Alg44 as small as 24 amino acids blocked alginate polymerization in vivo, indicating a critical role for the MFP domain. These studies suggest that Alg44 may act as a co-polymerase in concert with Alg8, the major GT, and that both inner-membrane proteins are required in vivo for the polymerization reaction leading to alginate production.

Published
2008

16. Requirement for yaeT in the outer membrane assembly of Autotransporter proteins

Author

Jain, Sumita and Goldberg, Marcia B.

Subjects
Gram-negative bacteria -- Genetic aspects, Gram-negative bacteria -- Research, Membrane proteins -- Research, Translocation (Genetics) -- Research, Biological sciences
Abstract

Autotransporters constitute the largest group of secreted proteins in gram-negative bacteria. Autotransporter secretion involves the insertion of a carboxy-terminal beta barrel into and the translocation of an amino-terminal domain across the outer membrane. Here, we demonstrate that secretion of autotransporters from several organisms requires the outer membrane assembly factor YaeT.

Published
2007

17. Polar localization of the autotransporter family of large bacterial virulence proteins

Author

Jain, Sumita, van Ulsen, Peter, Benz, Inga, Schmidt, M. Alexander, Fernandez, Rachel, Tommassen, Jan, and Goldberg, Marcia B.

Subjects
Escherichia coli -- Physiological aspects, Bacterial proteins -- Research, Virulence (Microbiology) -- Research, Biological sciences
Abstract

Autotransporters are an extensive family of large secreted virulence-associated proteins of gram-negative bacteria. Secretion of such large proteins poses unique challenges to bacteria. We demonstrate that autotransporters from a wide variety of rod-shaped pathogens, including IcsA and SepA of Shigella flexneri, AIDA-I of diffusely adherent Escherichia coli, and BrkA of Bordetella pertussis, are localized to the bacterial pole. The restriction of autotransporters to the pole is dependent on the presence of a complete lipopolysaccharide (LPS), consistent with known effects of LPS composition on membrane fluidity. Newly synthesized and secreted BrkA is polar even in the presence of truncated LPS, and all autotransporters examined are polar in the cytoplasm prior to secretion. Together, these findings are consistent with autotransporter secretion occurring at the poles of rod-shaped gram-negative organisms. Moreover, NalP, an autotransporter of spherically shaped Neisseria meningitidis contains the molecular information to localize to the pole of Escherichia coil In N. meningitidis, NalP is secreted at distinct sites around the cell. These data are consistent with a model in which the secretion of large autotransporters occurs via specific conserved pathways located at the poles of rod-shaped bacteria, with profound implications for the underlying physiology of the bacterial cell and the nature of bacterial pathogen-host interactions.

Published
2006

18. Genomic and Functional Characterization of a Mucosal Symbiont Involved in Early-Stage Colorectal Cancer

Author

Kordahi, Melissa, primary, Avril, Mariion, additional, Stanaway, Ian, additional, Chac, Denise, additional, Ross, B., additional, Diener, C, additional, Jain, Sumita, additional, McCleary, P., additional, Parker, Anika, additional, Friedman, Vince, additional, Huang, J, additional, Burke, Wynn, additional, Gibbons, Sean, additional, Willis, AD, additional, Darveau, Richard, additional, Grady, WM, additional, Ko, Cynthia, additional, and DePaolo, R. William, additional

Published
2021
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19. The Pseudomonas fluorescens AlgG protein, but not its mannuronan C-5-epimerase activity, is needed for alginate polymer formation

Author

Gimmestad, Martin, Sletta, Havard, Ertesvag, Helga, Bakkevig, Karianne, Jain, Sumita, Suh, Sang-jin, Skjak-Braek, Gudmund, Ellingsen, Trond E., Ohman, Dennis E., and Valla, Svein

Subjects
Gene expression -- Physiological aspects, Enzymes -- Genetic aspects, Bacterial proteins -- Genetic aspects, Amino acids -- Physiological aspects, Pseudomonas fluorescens -- Genetic aspects, Microbial populations -- Genetic aspects, Bacteriology -- Research, Biological sciences
Abstract

Bacterial alginates are produced as 1-4-linked [beta]-D-mannuronan, followed by epimerization of some of the mannuronic acid residues to [alpha]-L-guluronic acid. Here we report the isolation of four different epimerization-defective point mutants of the periplasmic Pseudomonas fluorescens mannuronan C-5-epimerase AlgG. All mutations affected amino acids conserved among AlgG-epimerases and were clustered in a part of the enzyme also sharing some sequence similarity to a group of secreted epimerases previously reported in Azotobacter vinelandii. An algG-deletion mutant was constructed and found to produce predominantly a dimer containing a 4-deoxy-L-erythro-hex-4-enepyranosyluronate residue at the nonreducing end and a mannuronic acid residue at the reducing end. The production of this dimer is the result of the activity of an alginate lyase, AlgL, whose in vivo activity is much more limited in the presence of AlgG. A strain expressing both an epimerase-defective (point mutation) and a wild-type epimerase was constructed and shown to produce two types of alginate molecules: one class being pure mannuronan and the other having the wild-type content of guluronic acid residues. This formation of two distinct classes of polymers in a genetically pure cell line can be explained by assuming that AlgG is part of a periplasmic protein complex.

Published
2003

20. Comparative study of operative procedures in typhoid perforation

Author

Beniwal, Udai Singh, Jindal, Dinesh, Sharma, Jagdish, Jain, Sumita, and Shyam, Ghan

Subjects
Colostomy -- Methods -- Comparative analysis, Statistics -- Comparative analysis -- Methods, Typhoid fever -- Care and treatment -- Comparative analysis, Surgery -- Methods -- Comparative analysis -- Complications, Health, Care and treatment, Evaluation, Comparative analysis, Methods
Abstract

Code Number: is03030 ABSTRACT The present study was conducted in 200 patients of typhoid perforation treated surgically. The aim of the study was to compare the results of different operative [...]

Published
2003

27. Deletion of algK in mucoid Pseudomonas aeruginosa blocks alginate polymer formation and results in uronic acid secretion

Author

Jain, Sumita and Ohman, Dennis E.

Subjects
Pseudomonas aeruginosa -- Research, Biosynthesis -- Methods, Biological sciences
Abstract

A study was conducted to identify the effects of deleting algK in mucoid Pseudomonas aeruginosa. Infection by this bacteria is a common problem experienced by patients afflicted with cystic fibrosis. The alginate biosynthesis process begins with the formation of the GDP-mannuronate. AlgK is sequenced from the mucoid CF isolate FRD1. This gene is characterized by a periplasmic subcellular localization as seen from the active AlgK-PhoA fusion proteins.

Published
1998

33. In vitro microbiologic evaluation of PTFE and cotton as spacer materials.

Author

Paranjpe, Avina, Jain, Sumita, Alibhai, Karim Z., Wadhwani, Chandur P., Darveau, Richard P., and Johnson, James D.

Subjects
MICROBIAL contamination, POLYTEF, BACTERIA, BIOPHYSICS, DENTAL materials, DENTAL fillings, RESEARCH methodology, MOLARS, STATISTICAL sampling, DENTAL extraction, THERAPEUTICS
Abstract

Objective: To microbiologically evaluate the efficacy of cotton and polytetrafluoroethylene (PTFE) tape used as spacer materials. Method and Materials: Twenty-six extracted human molars were restored using either cotton or PTFE tape as spacers under a standardized provisional material (Cavit). The teeth were incubated for 7 days in a culture of Streptococcus gordonii or in liquid media alone. The spacers were removed and tested for bacterial contamination. The access cavities were also evaluated for bacterial contamination. Results: Nine of 10 teeth with cotton spaces and one of 10 teeth with PTFE spacers were positive for S gordonii growth. The nine teeth in the cotton group also showed contamination of the access cavities. Conclusion: Even under optimal conditions, cotton spacers may cause leakage into the access cavities. Cotton fibers may serve as a route for bacterial contamination of the access cavities and root canal space. In contrast, PTFE tape did not provide an avenue for bacterial contamination. [ABSTRACT FROM AUTHOR]

Published
2012

36. Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: a prospective multicentre study (WISS Study)

Author

Sartelli, Massimo, primary, Abu-Zidan, Fikri M., additional, Catena, Fausto, additional, Griffiths, Ewen A., additional, Di Saverio, Salomone, additional, Coimbra, Raul, additional, Ordoñez, Carlos A., additional, Leppaniemi, Ari, additional, Fraga, Gustavo P., additional, Coccolini, Federico, additional, Agresta, Ferdinando, additional, Abbas, Asrhaf, additional, Abdel Kader, Saleh, additional, Agboola, John, additional, Amhed, Adamu, additional, Ajibade, Adesina, additional, Akkucuk, Seckin, additional, Alharthi, Bandar, additional, Anyfantakis, Dimitrios, additional, Augustin, Goran, additional, Baiocchi, Gianluca, additional, Bala, Miklosh, additional, Baraket, Oussama, additional, Bayrak, Savas, additional, Bellanova, Giovanni, additional, Beltràn, Marcelo A., additional, Bini, Roberto, additional, Boal, Matthew, additional, Borodach, Andrey V., additional, Bouliaris, Konstantinos, additional, Branger, Frederic, additional, Brunelli, Daniele, additional, Catani, Marco, additional, Che Jusoh, Asri, additional, Chichom-Mefire, Alain, additional, Cocorullo, Gianfranco, additional, Colak, Elif, additional, Costa, David, additional, Costa, Silvia, additional, Cui, Yunfeng, additional, Curca, Geanina Loredana, additional, Curry, Terry, additional, Das, Koray, additional, Delibegovic, Samir, additional, Demetrashvili, Zaza, additional, Di Carlo, Isidoro, additional, Drozdova, Nadezda, additional, El Zalabany, Tamer, additional, Enani, Mushira Abdulaziz, additional, Faro, Mario, additional, Gachabayov, Mahir, additional, Giménez Maurel, Teresa, additional, Gkiokas, Georgios, additional, Gomes, Carlos Augusto, additional, Gonsaga, Ricardo Alessandro Teixeira, additional, Guercioni, Gianluca, additional, Guner, Ali, additional, Gupta, Sanjay, additional, Gutierrez, Sandra, additional, Hutan, Martin, additional, Ioannidis, Orestis, additional, Isik, Arda, additional, Izawa, Yoshimitsu, additional, Jain, Sumita A., additional, Jokubauskas, Mantas, additional, Karamarkovic, Aleksandar, additional, Kauhanen, Saila, additional, Kaushik, Robin, additional, Kenig, Jakub, additional, Khokha, Vladimir, additional, Kim, Jae Il, additional, Kong, Victor, additional, Koshy, Renol, additional, Krasniqi, Avidyl, additional, Kshirsagar, Ashok, additional, Kuliesius, Zygimantas, additional, Lasithiotakis, Konstantinos, additional, Leão, Pedro, additional, Lee, Jae Gil, additional, Leon, Miguel, additional, Lizarazu Pérez, Aintzane, additional, Lohsiriwat, Varut, additional, López-Tomassetti Fernandez, Eudaldo, additional, Lostoridis, Eftychios, additional, Mn, Raghuveer, additional, Major, Piotr, additional, Marinis, Athanasios, additional, Marrelli, Daniele, additional, Martinez-Perez, Aleix, additional, Marwah, Sanjay, additional, McFarlane, Michael, additional, Melo, Renato Bessa, additional, Mesina, Cristian, additional, Michalopoulos, Nick, additional, Moldovanu, Radu, additional, Mouaqit, Ouadii, additional, Munyika, Akutu, additional, Negoi, Ionut, additional, Nikolopoulos, Ioannis, additional, Nita, Gabriela Elisa, additional, Olaoye, Iyiade, additional, Omari, Abdelkarim, additional, Ossa, Paola Rodríguez, additional, Ozkan, Zeynep, additional, Padmakumar, Ramakrishnapillai, additional, Pata, Francesco, additional, Pereira Junior, Gerson Alves, additional, Pereira, Jorge, additional, Pintar, Tadeja, additional, Pouggouras, Konstantinos, additional, Prabhu, Vinod, additional, Rausei, Stefano, additional, Rems, Miran, additional, Rios-Cruz, Daniel, additional, Sakakushev, Boris, additional, Sánchez de Molina, Maria Luisa, additional, Seretis, Charampolos, additional, Shelat, Vishal, additional, Simões, Romeo Lages, additional, Sinibaldi, Giovanni, additional, Skrovina, Matej, additional, Smirnov, Dmitry, additional, Spyropoulos, Charalampos, additional, Tepp, Jaan, additional, Tezcaner, Tugan, additional, Tolonen, Matti, additional, Torba, Myftar, additional, Ulrych, Jan, additional, Uzunoglu, Mustafa Yener, additional, van Dellen, David, additional, van Ramshorst, Gabrielle H., additional, Vasquez, Giorgio, additional, Venara, Aurélien, additional, Vereczkei, Andras, additional, Vettoretto, Nereo, additional, Vlad, Nutu, additional, Yadav, Sanjay Kumar, additional, Yilmaz, Tonguç Utku, additional, Yuan, Kuo-Ching, additional, Zachariah, Sanoop Koshy, additional, Zida, Maurice, additional, Zilinskas, Justas, additional, and Ansaloni, Luca, additional

Published
2015
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48. The Lipid A Phosphate Position Determines Differential Host Toll-Like Receptor 4 Responses to Phylogenetically Related Symbiotic and Pathogenic Bacteria

Author

Coats, Stephen R., Berezow, Alex B., To, Thao T., Jain, Sumita, Bainbridge, Brian W., Banani, Karim P., and Darveau, Richard P.

Abstract

ABSTRACTThe human symbiont Bacteroides thetaiotaomicronpromotes intestinal function and health, whereas the phylogenetically related pathogen Porphyromonas gingivalisis associated with the chronic oral inflammatory disease periodontitis. Although both B. thetaiotaomicronand P. gingivalissynthesize lipopolysaccharides (LPS) consisting of penta-acylated, monophosphorylated lipid A in addition to immunologically silent, nonphosphorylated lipid A, they elicit strikingly distinct Toll-like receptor 4 (TLR4) responses. We show that the phosphate position of penta-acylated, monophosphorylated lipid A is a key feature for determining the differential TLR4 responses elicited by these evolutionarily related bacteria. B. thetaiotaomicronproduces TLR4-stimulatory lipid A bearing a 1-phosphate, in contrast to P. gingivalis, which produces TLR4-evasive lipid A bearing a 4′-phosphate. Confirming these observations, recombinant Escherichia coliLPS containing penta-acylated, 1-phosphorylated lipid A is more TLR4 stimulatory than LPS containing 4′-phosphorylated lipid A. The specific capacity of a Gram-negative bacterium to alert or evade the host innate immune defense system through TLR4-dependent signaling is currently recognized as a critical aspect defining the relationship between the host and the bacterium. We propose that the distinct lipid A phosphate positions observed for the B. thetaiotaomicronand P. gingivalisLPS contributes to the manifestation of these bacteria as commensal or pathogen within the human host.

Published
2010
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49. The Small Nucleoid-Binding Proteins H-NS, HU, and Fis Affect hilAExpression in Salmonella entericaSerovar Typhimurium

Author

Schechter, Lisa M., Jain, Sumita, Akbar, Samina, and Lee, Catherine A.

Abstract

ABSTRACThilAencodes an activator of Salmonella entericaserovar Typhimurium virulence genes and is transcriptionally modulated by environmental conditions. We show that H-NS represses hilAunder low-osmolarity conditions. H-NS, HU, and Fis also appear to affect the derepression of hilAby HilD. Modulation of hilAby counteracting repressing and derepressing mechanisms may allow Salmonellaserovar Typhimurium to regulate its virulence genes in response to different situations in vivo.

Published
2003
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50. Clinicopathological Features Of Triple Positive Breast Cancer: A Perspective Analysis.

Author

Jain, Sumita A.

Subjects
*BREAST cancer, *TRIPLE-negative breast cancer, *HORMONE therapy, *GENE expression, *TUMOR classification, *DESCRIPTIVE statistics
Abstract

Clinicopathological Features of Triple positive Breast Cancer: A Perspective Analysis Dr. Anil Kumar Khyalia, Dr. Sumita A Jain Abstract: Aim • The aim is to study various clinicopathological features of TPBC in Northern part of INDIA. Background: • Molecular classification of breast cancer is based on gene expressing profile. • They subgroup [luminal A, luminal B, HER2, and basal like] have distinct gene expression pattern and phenotypical characteristics. • HER2 positive associated with TP53mutations • They are associated with less aggressive histology, good clinical outcome, and responsive to endocrine therapy and short survival. Material And Method: • Study Design: Hospital based retrospective, descriptive type of observational study. • Study place: Dept. of general surgery SMS hospital Jaipur. • Study population: 370 cases of diagnosed breast cancer. • Statistical Analysis: Descriptive statistics. Result: • Total breast cancer patients studied = 370 • 32 patients [8.5%] were found to have TPBC • Most [56.6 %] were before the age of 48 years. • More common in pre menopausal women[60 %] • Most of TPBC [96.6 %] had histological features of IDC Conclusions: ? TPBC represents around 9 % of breast cancer. ? TPBC is commonly associated with pre menopausal status before the age of 45 years. ? TBC is commonly infiltrative duc histology. [ABSTRACT FROM AUTHOR]

Published
2017

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