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Purpose: To evaluate changes in corneal backscattering after collagen cross-linking (CXL) for progressive keratoconus and compare its course with different techniques - standard epithelium-off CXL (SCXL), contact lens-assisted CXL (CACXL), and transepithelial CXL (TECXL). Setting: Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Design: Retrospective comparative study. Methods: Ninety-four eyes (SCXL: 47, CACXL: 30, and TECXL: 17) were compared. Corneal haze was quantified using Scheimpflug tomography, pre- and post-CXL at 1, 3, 6, and 12 months. Results: The baseline mean density score of the central anterior stromal layer was 16.14 ± 7.07, 15.85 ± 7.89 and 15.89 ± 7.21 in SCXL, CACXL, and TECXL groups, respectively (P 0.93). After SCXL, the score increased to 28.83 and 31.34 at 1 and 3 months, respectively (both P < 0.001) and dropped at 6 months (28.66, P < 0.001) and 12 months (23.72, P 0.003). Post-CACXL, the mean densitometry peaked at 3 months (20.35, P 0.14) and returned toward baseline at 6 months (18.82, P 0.15). After TECXL, it increased slightly at 1 month (18.47, P 0.17), decreased at 3 months (14.88, P 0.7), and plateaued over 1 year. No correlation with visual acuity was seen. Conclusion: Corneal haze increased significantly after SCXL, peaking at 3 months, declining over 6-12 months, and returning to baseline at 12 months. In contrast, post-TECXL and -CACXL, there was an insignificant increase in anterior corneal haze, which returned to baseline within 3-6 months. Keywords: Contact lens-assisted corneal cross-linking, corneal densitometry, 'epithelium-off' corneal cross-linking, keratoconus, transepithelial corneal cross-linking, Author(s): Barkha Gupta [1]; Chintan Malhotra (corresponding author) [1]; Supriya Dhar [1]; Khushdeep Abhyapal [1]; Arun K. Jain [1]; Amit Gupta [1] Keratoconus, an ectatic corneal disorder characterized by progressive [...]

This study aimed to comprehensively explore the intricacies of corneal neurotization (CN) and the nuanced factors that set it apart from routine clinical practice, exerting a substantial influence on its success. A symbiotic relationship is evident between corneal innervation and ocular surface health. The loss of corneal innervation results in a potentially challenging corneal condition known as neurotrophic keratopathy (NK). The majority of treatments are primarily focused on preventing epithelial breakdown rather than addressing the underlying pathogenesis. Consequently, to address the impaired corneal sensation (underlying etiology), a novel surgical approach has emerged, namely CN, which involves transferring healthy sensory nerve axons to the affected cornea. This review offers valuable insights into the existing body of supporting evidence for CN, meticulously examining clinical studies, case reports, and experimental findings. The aim is to enhance our understanding of the effectiveness and potential outcomes associated with this innovative surgical technique. The exploration of innovative therapeutic avenues holds promise for revolutionizing the management of NK, offering a potentially permanent solution to a condition once deemed incurable and severely debilitating. Keywords: Corneal neurotization, donor nerve, insensate cornea, interpositional nerve graft, neurotrophic keratopathy, reinnervation, Author(s): Manu Saini [1]; Arun Jain [1]; Murugesan Vanathi (corresponding author) [2]; Aman Kalia [1]; Kulbhushan Saini [3]; Parul Gupta [1]; Nripen Gaur [4] Neurotrophic keratopathy (NK) represents a rare [...]

Byline: Anchal. Thakur, Sushant. Adiga, Chintan. Malhotra, Kulbhushan. Sachdeva, Shubhi. Singh, Arun. Jain Purpose: To perform an intraindividual comparison of the quality of vision and the effect of decentration between [...]

Byline: Anchal. Thakur, Muskaan. Bansal, Divya. Challa, Chintan. Malhotra, Arun. Jain We describe a technique of scleral IOL fixation and optic centration of in the capsular bag subluxated IOL in [...]

Byline: Syeda. Mobeen, Pallavi. Saxena, Arun. Jain, Ravi. Deval, Khateef. Riazunnisa, Dibyabhaba. Pradhan Background: Colorectal cancer (CRC) is the fifth leading cause of death in India. Until now, the exact [...]

Byline: Muskaan. Bansal, Anchal. Thakur, Gaurav. Gupta, Ajay. Jurangal, Rahul. Khanna, Chintan. Malhotra, Amit. Gupta, Arun. Jain Purpose: This study was conducted to evaluate the accuracy of intraoperative aberrometry (IA) [...]

Byline: Anchal. Thakur, Surya. Sharma, Barkha. Gupta, Sraddha. Limbu, Chintan. Malhotra, Arun. Jain A 40-year-old female presented with pain, redness, watering, and foreign body sensation for three days duration. Visual [...]

Byline: Anchal. Thakur, Arun. Jain Corneal epithelium is the anteriormost layer of the cornea, which contributes to refractive power of the eye, minimizes stromal irregularity, as well as provides a [...]

Byline: Chintan. Malhotra, Barkha. Gupta, Rajneesh. Dhiman, Arun. Jain, Amit. Gupta, Jagat. Ram Purpose: To determine the pattern of corneal thickness and epithelial thickness distribution in healthy North Indian eyes [...]

Byline: Anchal. Thakur, Arun. Jain Successful removal of a hard cataract is accomplished by careful history taking, complete physical examination, the surgical technique chosen, incision creation, good capsulorhexis, hydrodissection, pupil [...]