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1. Correction: Real‑world data suggest effectiveness of the allogeneic mesenchymal stromal cells preparation MSC‑FFM in ruxolitinib‑refractory acute graft‑versus‑host disease

Author

Bonig, Halvard, Verbeek, Mareike, Herhaus, Peter, Braitsch, Krischan, Beutel, Gernot, Schmid, Christoph, Müller, Nadine, Bug, Gesine, Döring, Michaela, von Stackelberg, Arend, Tischer, Johanna, Ayuk, Francis, Wulf, Gerald, Holtick, Udo, Pfeffermann, Lisa‑Marie, Jahrsdörfer, Bernd, Schrezenmeier, Hubert, Kuci, Selim, Kuci, Zyrafete, Zens, Anke, Tribanek, Michael, Zeiser, Robert, Huenecke, Sabine, and Bader, Peter

Published
2024
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2. High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection.

Author

Jacobsen, Eva-Maria, Fabricius, Dorit, Class, Magdalena, Topfstedt, Fernando, Lorenzetti, Raquel, Janowska, Iga, Schmidt, Franziska, Staniek, Julian, Zernickel, Maria, Stamminger, Thomas, Dietz, Andrea N, Zellmer, Angela, Hecht, Manuel, Rauch, Peter, Blum, Carmen, Ludwig, Carolin, Jahrsdörfer, Bernd, Schrezenmeier, Hubert, Heeg, Maximilian, Mayer, Benjamin, Seidel, Alina, Groß, Rüdiger, Münch, Jan, Kirchhoff, Frank, Bode, Sebastian FN, Strauss, Gudrun, Renk, Hanna, Elling, Roland, Stich, Maximillian, Voll, Reinhard E, Tönshof, Burkhard, Franz, Axel R, Henneke, Philipp, Debatin, Klaus-Michael, Rizzi, Marta, and Janda, Ales

Subjects
Humans, Immunization, Secondary, Antibody Formation, Adult, Child, Antibodies, Neutralizing, COVID-19, SARS-CoV-2, Immunization, Biodefense, Emerging Infectious Diseases, Infectious Diseases, Prevention, Pediatric, Vaccine Related, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Infection, Good Health and Well Being
Abstract

The COVID-19 course and immunity differ in children and adults. We analyzed immune response dynamics in 28 families up to 12 months after mild or asymptomatic infection. Unlike adults, the initial response is plasmablast-driven in children. Four months after infection, children show an enhanced specific antibody response and lower but detectable spike 1 protein (S1)-specific B and T cell responses than their parents. While specific antibodies decline, neutralizing antibody activity and breadth increase in both groups. The frequencies of S1-specific B and T cell responses remain stable. However, in children, one year after infection, an increase in the S1-specific IgA class switch and the expression of CD27 on S1-specific B cells and T cell maturation are observed. These results, together with the enhanced neutralizing potential and breadth of the specific antibodies, suggest a progressive maturation of the S1-specific immune response. Hence, the immune response in children persists over 12 months but dynamically changes in quality, with progressive neutralizing, breadth, and memory maturation. This implies a benefit for booster vaccination in children to consolidate memory formation.

Published
2022

3. Real-world data suggest effectiveness of the allogeneic mesenchymal stromal cells preparation MSC-FFM in ruxolitinib-refractory acute graft-versus-host disease

Author

Bonig, Halvard, Verbeek, Mareike, Herhaus, Peter, Braitsch, Krischan, Beutel, Gernot, Schmid, Christoph, Müller, Nadine, Bug, Gesine, Döring, Michaela, von Stackelberg, Arend, Tischer, Johanna, Ayuk, Francis, Wulf, Gerald, Holtick, Udo, Pfeffermann, Lisa-Marie, Jahrsdörfer, Bernd, Schrezenmeier, Hubert, Kuci, Selim, Kuci, Zyrafete, Zens, Anke, Tribanek, Michael, Zeiser, Robert, Huenecke, Sabine, and Bader, Peter

Published
2023
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4. Robust and durable serological response following pediatric SARS-CoV-2 infection

Author

Renk, Hanna, Dulovic, Alex, Seidel, Alina, Becker, Matthias, Fabricius, Dorit, Zernickel, Maria, Junker, Daniel, Groß, Rüdiger, Müller, Janis, Hilger, Alexander, Bode, Sebastian F. N., Fritsch, Linus, Frieh, Pauline, Haddad, Anneke, Görne, Tessa, Remppis, Jonathan, Ganzemueller, Tina, Dietz, Andrea, Huzly, Daniela, Hengel, Hartmut, Kaier, Klaus, Weber, Susanne, Jacobsen, Eva-Maria, Kaiser, Philipp D., Traenkle, Bjoern, Rothbauer, Ulrich, Stich, Maximilian, Tönshoff, Burkhard, Hoffmann, Georg F., Müller, Barbara, Ludwig, Carolin, Jahrsdörfer, Bernd, Schrezenmeier, Hubert, Peter, Andreas, Hörber, Sebastian, Iftner, Thomas, Münch, Jan, Stamminger, Thomas, Groß, Hans-Jürgen, Wolkewitz, Martin, Engel, Corinna, Liu, Weimin, Rizzi, Marta, Hahn, Beatrice H., Henneke, Philipp, Franz, Axel R., Debatin, Klaus-Michael, Schneiderhan-Marra, Nicole, Janda, Ales, and Elling, Roland

Published
2022
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7. SARS-CoV-2 vaccination of convalescents boosts neutralization capacity against Omicron subvariants BA.1, BA.2 and BA.5 and can be predicted by anti-S antibody concentrations in serological assays

Author

Seidel, Alina, primary, Hoffmann, Simone, additional, Jahrsdörfer, Bernd, additional, Körper, Sixten, additional, Ludwig, Carolin, additional, Vieweg, Christiane, additional, Albers, Dan, additional, von Maltitz, Pascal, additional, Müller, Rebecca, additional, Lotfi, Ramin, additional, Wuchter, Patrick, additional, Klüter, Harald, additional, Kirchhoff, Frank, additional, Schmidt, Michael, additional, Münch, Jan, additional, and Schrezenmeier, Hubert, additional

Published
2023
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8. Data from Interleukin 21–Induced Granzyme B–Expressing B Cells Infiltrate Tumors and Regulate T Cells

Author

Lindner, Stefanie, primary, Dahlke, Karen, primary, Sontheimer, Kai, primary, Hagn, Magdalena, primary, Kaltenmeier, Christof, primary, Barth, Thomas F.E., primary, Beyer, Thamara, primary, Reister, Frank, primary, Fabricius, Dorit, primary, Lotfi, Ramin, primary, Lunov, Oleg, primary, Nienhaus, G. Ulrich, primary, Simmet, Thomas, primary, Kreienberg, Rolf, primary, Möller, Peter, primary, Schrezenmeier, Hubert, primary, and Jahrsdörfer, Bernd, primary

Published
2023
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9. Supplementary Methods and Figure Legend from Interleukin 21–Induced Granzyme B–Expressing B Cells Infiltrate Tumors and Regulate T Cells

Author

Lindner, Stefanie, primary, Dahlke, Karen, primary, Sontheimer, Kai, primary, Hagn, Magdalena, primary, Kaltenmeier, Christof, primary, Barth, Thomas F.E., primary, Beyer, Thamara, primary, Reister, Frank, primary, Fabricius, Dorit, primary, Lotfi, Ramin, primary, Lunov, Oleg, primary, Nienhaus, G. Ulrich, primary, Simmet, Thomas, primary, Kreienberg, Rolf, primary, Möller, Peter, primary, Schrezenmeier, Hubert, primary, and Jahrsdörfer, Bernd, primary

Published
2023
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10. Supplementary Video 1 from Interleukin 21–Induced Granzyme B–Expressing B Cells Infiltrate Tumors and Regulate T Cells

Author

Lindner, Stefanie, primary, Dahlke, Karen, primary, Sontheimer, Kai, primary, Hagn, Magdalena, primary, Kaltenmeier, Christof, primary, Barth, Thomas F.E., primary, Beyer, Thamara, primary, Reister, Frank, primary, Fabricius, Dorit, primary, Lotfi, Ramin, primary, Lunov, Oleg, primary, Nienhaus, G. Ulrich, primary, Simmet, Thomas, primary, Kreienberg, Rolf, primary, Möller, Peter, primary, Schrezenmeier, Hubert, primary, and Jahrsdörfer, Bernd, primary

Published
2023
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11. Supplementary Figures 1 - 7 from Interleukin 21–Induced Granzyme B–Expressing B Cells Infiltrate Tumors and Regulate T Cells

Author

Lindner, Stefanie, primary, Dahlke, Karen, primary, Sontheimer, Kai, primary, Hagn, Magdalena, primary, Kaltenmeier, Christof, primary, Barth, Thomas F.E., primary, Beyer, Thamara, primary, Reister, Frank, primary, Fabricius, Dorit, primary, Lotfi, Ramin, primary, Lunov, Oleg, primary, Nienhaus, G. Ulrich, primary, Simmet, Thomas, primary, Kreienberg, Rolf, primary, Möller, Peter, primary, Schrezenmeier, Hubert, primary, and Jahrsdörfer, Bernd, primary

Published
2023
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13. One-year follow-up of the CAPSID randomized trial for high-dose convalescent plasma in severe COVID-19 patients

Author

Körper, Sixten, primary, Grüner, Beate, additional, Zickler, Daniel, additional, Wiesmann, Thomas, additional, Wuchter, Patrick, additional, Blasczyk, Rainer, additional, Zacharowski, Kai, additional, Spieth, Peter, additional, Tonn, Torsten, additional, Rosenberger, Peter, additional, Paul, Gregor, additional, Pilch, Jan, additional, Schwäble, Joachim, additional, Bakchoul, Tamam, additional, Thiele, Thomas, additional, Knörlein, Julian, additional, Dollinger, Matthias M., additional, Krebs, Jörg, additional, Bentz, Martin, additional, Corman, Victor M., additional, Kilalic, Dzenan, additional, Schmidtke-Schrezenmeier, Gerlinde, additional, Lepper, Philipp M., additional, Ernst, Lucas, additional, Wulf, Hinnerk, additional, Ulrich, Alexandra, additional, Weiss, Manfred, additional, Kruse, Jan Matthias, additional, Burkhardt, Thomas, additional, Müller, Rebecca, additional, Klüter, Harald, additional, Schmidt, Michael, additional, Jahrsdörfer, Bernd, additional, Lotfi, Ramin, additional, Rojewski, Markus, additional, Appl, Thomas, additional, Mayer, Benjamin, additional, Schnecko, Philipp, additional, Seifried, Erhard, additional, and Schrezenmeier, Hubert, additional

Published
2022
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14. Differentially induced immunity in buccal and nasal mucosae after vaccination for SARS–CoV–2: Prospects for mass scale immunity-screening in large populations

Author

Tsamadou, Chrysanthi, primary, Ludwig, Carolin, additional, Scholz, Judith, additional, Proffen, Matthias, additional, Hägele, Janina, additional, Rode, Immanuel, additional, Körper, Sixten, additional, Fabricius, Dorit, additional, Jahrsdörfer, Bernd, additional, Neuchel, Christine, additional, Amann, Elisa, additional, Schrezenmeier, Hubert, additional, and Fürst, Daniel, additional

Published
2022
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15. Cytokine levels associated with favorable clinical outcome in the CAPSID randomized trial of convalescent plasma in patients with severe COVID-19

Author

Körper, Sixten, primary, Schrezenmeier, Eva Vanessa, additional, Rincon-Arevalo, Hector, additional, Grüner, Beate, additional, Zickler, Daniel, additional, Weiss, Manfred, additional, Wiesmann, Thomas, additional, Zacharowski, Kai, additional, Kalbhenn, Johannes, additional, Bentz, Martin, additional, Dollinger, Matthias M., additional, Paul, Gregor, additional, Lepper, Philipp M., additional, Ernst, Lucas, additional, Wulf, Hinnerk, additional, Zinn, Sebastian, additional, Appl, Thomas, additional, Jahrsdörfer, Bernd, additional, Rojewski, Markus, additional, Lotfi, Ramin, additional, Dörner, Thomas, additional, Jungwirth, Bettina, additional, Seifried, Erhard, additional, Fürst, Daniel, additional, and Schrezenmeier, Hubert, additional

Published
2022
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16. Phorbol-12-myristate-13-acetate is a potent enhancer of B cells with a granzyme B+ regulatory phenotype.

Author

Veh, Johanna, Mangold, Charlotte, Felsen, Anja, Ludwig, Carolin, Gerstner, Lisa, Reinhardt, Peter, Schrezenmeier, Hubert, Fabricius, Dorit, and Jahrsdörfer, Bernd

Subjects
B cells, REGULATORY B cells, B cell receptors, B cell differentiation, GRANZYMES, Q fever
Abstract

Introduction: The infusion of ex-vivo-generated regulatory B cells may represent a promising novel therapeutic approach for a variety of autoimmune and hyperinflammatory conditions including graft-versus-host disease. Methods: Previously, we developed a protocol for the generation of a novel population of regulatory B cells, which are characterized by secretion of enzymatically active granzyme B (GraB cells). This protocol uses recombinant interleukin 21 (IL-21) and goat-derived F(ab)’2 fragments against the human B cell receptor (anti-BCR). Generally, the use of xenogeneic material for the manufacturing of advanced therapy medicinal products should be avoided to prevent adverse immune reactions as well as potential transmission of so far unknown diseases. Results: In the present work we demonstrated that phorbol-12-myristate-13- acetate (PMA/TPA), a phorbol ester with a particular analogy to the second messenger diacylglycerol (DAG), is a potent enhancer of IL-21-induced differentiation of pre-activated B cells into GraB cells. The percentage of GraB cells after stimulation of pre-activated B cells with IL-21 and PMA/TPA was not significantly lower compared to stimulation with IL-21 and anti-BCR. Discussion: Given that PMA/TPA has already undergone encouraging clinical testing in patients with certain haematological diseases, our results suggest that PMA/TPA may be a safe and feasible alternative for ex-vivo manufacturing of GraB cells. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Persistent but atypical germinal center reaction among 3rd SARS-CoV-2 vaccination after rituximab exposure

Author

Stefanski, Ana-Luisa, primary, Rincon-Arevalo, Hector, additional, Schrezenmeier, Eva, additional, Karberg, Kirsten, additional, Szelinski, Franziska, additional, Ritter, Jacob, additional, Chen, Yidan, additional, Meisel, Christian, additional, Jahrsdörfer, Bernd, additional, Ludwig, Carolin, additional, Schrezenmeier, Hubert, additional, Lino, Andreia C., additional, and Dörner, Thomas, additional

Published
2022
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18. SARS-CoV2 mRNA Vaccine-Specific B-, T- and Humoral Responses in Adolescents After Kidney Transplantation

Author

Sattler, Arne, primary, Thumfart, Julia, additional, Tóth, Laura, additional, Schrezenmeier, Eva, additional, Proß, Vanessa, additional, Stahl, Carolin, additional, Siegle, Janine, additional, He, An, additional, Thole, Linda Marie Laura, additional, Ludwig, Carolin, additional, Straub-Hohenbleicher, Henriette, additional, Friedersdorff, Frank, additional, Jahrsdörfer, Bernd, additional, Schrezenmeier, Hubert, additional, Bufler, Philip, additional, and Kotsch, Katja, additional

Published
2022
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19. BNT162b2 Booster Vaccination Elicits Cross-Reactive Immunity Against SARS-CoV-2 Variants B.1.1.529 and B.1.617.2 in Convalescents of All Ages

Author

Jahrsdörfer, Bernd, primary, Proffen, Matthias, additional, Scholz, Judith, additional, Hägele, Janina, additional, Ludwig, Carolin, additional, Vieweg, Christiane, additional, Grempels, Aline, additional, Fabricius, Dorit, additional, Lotfi, Ramin, additional, Körper, Sixten, additional, Adler, Guido, additional, and Schrezenmeier, Hubert, additional

Published
2022
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20. Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination–specific humoral and cellular immunity in kidney transplant recipients

Author

Schrezenmeier, Eva, primary, Rincon-Arevalo, Hector, additional, Jens, Annika, additional, Stefanski, Ana-Luisa, additional, Hammett, Charlotte, additional, Osmanodja, Bilgin, additional, Koch, Nadine, additional, Zukunft, Bianca, additional, Beck, Julia, additional, Oellerich, Michael, additional, Proß, Vanessa, additional, Stahl, Carolin, additional, Choi, Mira, additional, Bachmann, Friederike, additional, Liefeldt, Lutz, additional, Glander, Petra, additional, Schütz, Ekkehard, additional, Bornemann-Kolatzki, Kirsten, additional, López del Moral, Covadonga, additional, Schrezenmeier, Hubert, additional, Ludwig, Carolin, additional, Jahrsdörfer, Bernd, additional, Eckardt, Kai-Uwe, additional, Lachmann, Nils, additional, Kotsch, Katja, additional, Dörner, Thomas, additional, Halleck, Fabian, additional, Sattler, Arne, additional, and Budde, Klemens, additional

Published
2022
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21. B Cell Characteristics at Baseline Predict Vaccination Response in RTX Treated Patients

Author

Stefanski, Ana-Luisa, primary, Rincon-Arevalo, Hector, additional, Schrezenmeier, Eva, additional, Karberg, Kirsten, additional, Szelinski, Franziska, additional, Ritter, Jacob, additional, Chen, Yidan, additional, Jahrsdörfer, Bernd, additional, Ludwig, Carolin, additional, Schrezenmeier, Hubert, additional, Lino, Andreia C., additional, and Dörner, Thomas, additional

Published
2022
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22. B Cell Numbers Predict Humoral and Cellular Response Upon SARS – CoV ‐2 Vaccination Among Patients Treated With Rituximab

Author

Stefanski, Ana‐Luisa, primary, Rincon‐Arevalo, Hector, additional, Schrezenmeier, Eva, additional, Karberg, Kirsten, additional, Szelinski, Franziska, additional, Ritter, Jacob, additional, Jahrsdörfer, Bernd, additional, Schrezenmeier, Hubert, additional, Ludwig, Carolin, additional, Sattler, Arne, additional, Kotsch, Katja, additional, Chen, Yidan, additional, Claußnitzer, Anne, additional, Haibel, Hildrun, additional, Proft, Fabian, additional, Guerra, Gabriela, additional, Durek, Pawel, additional, Heinrich, Frederik, additional, Ferreira‐Gomes, Marta, additional, Burmester, Gerd R., additional, Radbruch, Andreas, additional, Mashreghi, Mir‐Farzin, additional, Lino, Andreia C., additional, and Dörner, Thomas, additional

Published
2022
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23. High antibody and reduced cellular response in children up to one year after SARS-CoV-2 infection

Author

Jacobsen, Eva-Maria, primary, Fabricius, Dorit, additional, Class, Magdalena, additional, Topfstedt, Fernando, additional, Lorenzetti, Raquel, additional, Janowska, Iga, additional, Schmidt, Franziska, additional, Staniek, Julian, additional, Zernickel, Maria, additional, Stamminger, Thomas, additional, Dietz, Andrea, additional, Zellmer, Angela, additional, Hecht, Manuel, additional, Rauch, Peter, additional, Blum, Carmen, additional, Ludwig, Carolin, additional, Jahrsdörfer, Bernd, additional, Schrezenmeier, Hubert, additional, Heeg, Maximilian, additional, Mayer, Benjamin, additional, Seidel, Alina, additional, Groß, Rüdiger, additional, Münch, Jan, additional, Bode, Sebastian, additional, Strauss, Gudrun, additional, Renk, Hanna, additional, Elling, Roland, additional, Stich, Maximilian, additional, Voll, Reinhard, additional, Tönshoff, Burkhard, additional, Franz, Axel, additional, Henneke, Philipp, additional, Debatin, Klaus-Michael, additional, Rizzi, Marta, additional, and Janda, Aleš, additional

Published
2022
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24. SARS-CoV-2 vaccination of convalescents boosts neutralization capacity against SARS-CoV-2 Delta and Omicron that can be predicted by anti-S antibody concentrations in serological assays

Author

Seidel, Alina, primary, Jahrsdörfer, Bernd, additional, Körper, Sixten, additional, Albers, Dan, additional, Maltitz, Pascal von, additional, Müller, Rebecca, additional, Lotfi, Ramin, additional, Wuchter, Patrick, additional, Klüter, Harald, additional, Schmidt, Michael, additional, Münch, Jan, additional, and Schrezenmeier, Hubert, additional

Published
2022
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25. Temporary hold of mycophenolate boosts SARS-CoV-2 vaccination-specific humoral and cellular immunity in kidney transplant recipients

Author

Schrezenmeier, Eva, primary, Rincon-Arevalo, Hector, additional, Jens, Annika, additional, Stefanski, Ana-Luisa, additional, Hammett, Charlotte, additional, Osmanodja, Bilgin, additional, Koch, Nadine, additional, Zukunft, Bianca, additional, Beck, Julia, additional, Oellerich, Michael, additional, Pross, Vanessa, additional, Stahl, Carolin, additional, Choi, Mira, additional, Bachmann, Friederike, additional, Liefeldt, Lutz, additional, Glander, Petra, additional, Schütz, Ekkehard, additional, Bornemann-Kolatzki, Kirsten, additional, López del Moral, Covadonga, additional, Schrezenmeier, Hubert, additional, Ludwig, Carolin, additional, Jahrsdörfer, Bernd, additional, Eckardt, Kai-Uwe, additional, Lachmann, Nils, additional, Kotsch, Katja, additional, Dörner, Thomas, additional, Halleck, Fabian, additional, Sattler, Arne, additional, and Budde, Klemens, additional

Published
2022
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26. Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity against prevalent SARS-CoV-2 variants

Author

Groß, Rüdiger, primary, Zanoni, Michelle, additional, Seidel, Alina, additional, Conzelmann, Carina, additional, Gilg, Andrea, additional, Krnavek, Daniela, additional, Erdemci-Evin, Sümeyye, additional, Mayer, Benjamin, additional, Hoffmann, Markus, additional, Pöhlmann, Stefan, additional, Liu, Weimin, additional, Hahn, Beatrice H., additional, Beil, Alexandra, additional, Kroschel, Joris, additional, Jahrsdörfer, Bernd, additional, Schrezenmeier, Hubert, additional, Kirchhoff, Frank, additional, Münch, Jan, additional, and Müller, Janis A., additional

Published
2022
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27. B and T Cell Responses after a Third Dose of SARS-CoV-2 Vaccine in Kidney Transplant Recipients

Author

Schrezenmeier, Eva, primary, Rincon-Arevalo, Hector, additional, Stefanski, Ana-Luisa, additional, Potekhin, Alexander, additional, Staub-Hohenbleicher, Henriette, additional, Choi, Mira, additional, Bachmann, Friederike, additional, Proβ, Vanessa, additional, Hammett, Charlotte, additional, Schrezenmeier, Hubert, additional, Ludwig, Carolin, additional, Jahrsdörfer, Bernd, additional, Lino, Andreia C., additional, Eckardt, Kai-Uwe, additional, Kotsch, Katja, additional, Dörner, Thomas, additional, Budde, Klemens, additional, Sattler, Arne, additional, and Halleck, Fabian, additional

Published
2021
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28. B Cell Characteristics at Baseline Predict Vaccination Response in RTX Treated Patients

Author

Stefanski, Ana-Luisa, Rincon-Arevalo, Hector, Schrezenmeier, Eva, Karberg, Kirsten, Szelinski, Franziska, Ritter, Jacob, Chen, Yidan, Jahrsdörfer, Bernd, Ludwig, Carolin, Schrezenmeier, Hubert, Lino, Andreia C., and Dörner, Thomas

Subjects
SARS-CoV-2, Immunology, Vaccination, B-cells, COVID-19, prediction, Arthritis, Rheumatoid, Immunoglobulin G, Immunology and Allergy, SARS – CoV – 2, Humans, RTX (rituximab), Rituximab, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

Background: Vaccination is considered as most efficient strategy in controlling SARS-CoV-2 pandemic spread. Nevertheless, patients with autoimmune inflammatory rheumatic diseases receiving rituximab (RTX) are at increased risk to fail humoral and cellular responses upon vaccination. The ability to predict vaccination responses is essential to guide adequate safety and optimal protection in these patients. Methods: B- and T- cell data before vaccination were evaluated for characteristics predicting vaccine responses in altogether 15 patients with autoimmune inflammatory rheumatic diseases receiving RTX. Eleven patients with rheumatoid arthritis (RA) on other therapies, 11 kidney transplant recipients (KTR) on regular immunosuppression and 15 healthy controls (HC) served as controls. A multidimensional analysis of B cell subsets via UMAP algorithm and a correlation matrix were performed in order to identify predictive markers of response in patients under RTX therapy. Results: Significant differences regarding absolute B cell counts and specific subset distribution pattern between the groups were identified at baseline. In this context, the majority of B cells from vaccination responders of the RTX group (RTX IgG+) were naïve and transitional B cells, whereas vaccination non-responders (RTX IgG-) carried preferentially plasmablasts and double negative (CD27-IgD-) B cells. Moreover, there was a positive correlation between neutralizing antibodies and B cells expressing HLA-DR and CXCR5 as well as an inverse correlation with CD95 expression and CD21low expression by B cells among vaccination responders. Summary: Substantial repopulation of the naïve B cell compartment after RTX therapy appeared to be essential for an adequate vaccination response, which seem to require the additional capability of antigen presentation and germinal center formation. Moreover, expression of exhaustion markers represent negative predictors of vaccination responses.

Published
2021

30. Erytra blood group analyser and kode technology testing of SARS‐CoV‐2 antibodies among convalescent patients and vaccinated individuals

Author

Weinstock, Christof, primary, Flegel, Willy A., additional, Srivastava, Kshitij, additional, Kaiser, Sabine, additional, Schrezenmeier, Hubert, additional, Tsamadou, Chrysanthi, additional, Ludwig, Carolin, additional, Jahrsdörfer, Bernd, additional, Bovin, Nicolai V., additional, and Henry, Stephen M., additional

Published
2021
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31. Randomisierte Studien zum Einsatz von Rekonvaleszentenplasma bei COVID-19: eine Standortbestimmung

Author

Körper, Sixten, additional, Appl, Thomas, additional, Jahrsdörfer, Bernd, additional, Lotfi, Ramin, additional, Rojewski, Markus, additional, Wuchter, Patrick, additional, Tonn, Torsten, additional, Bakchoul, Tamam, additional, Karatas, Mesut, additional, Schmidt, Michael, additional, Klüter, Harald, additional, Seifried, Erhard, additional, and Schrezenmeier, Hubert, additional

Published
2021
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33. mRNA Vaccines Enhance Neutralizing Immunity against SARS-CoV-2 Variants in Convalescent and ChAdOx1-Primed Subjects

Author

Fabricius, Dorit, primary, Ludwig, Carolin, additional, Scholz, Judith, additional, Rode, Immanuel, additional, Tsamadou, Chrysanthi, additional, Jacobsen, Eva-Maria, additional, Winkelmann, Martina, additional, Grempels, Aline, additional, Lotfi, Ramin, additional, Janda, Aleš, additional, Körper, Sixten, additional, Adler, Guido, additional, Debatin, Klaus-Michael, additional, Schrezenmeier, Hubert, additional, and Jahrsdörfer, Bernd, additional

Published
2021
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35. B cell numbers predict humoral and cellular response upon SARS-CoV-2 vaccination among patients treated with rituximab

Author

Stefanski, Ana-Luisa, primary, Rincon-Arevalo, Hector, additional, Schrezenmeier, Eva, additional, Karberg, Kirsten, additional, Szelinski, Franziska, additional, Ritter, Jacob, additional, Jahrsdörfer, Bernd, additional, Schrezenmeier, Hubert, additional, Ludwig, Carolin, additional, Sattler, Arne, additional, Kotsch, Katja, additional, Chen, Yidan, additional, Claußnitzer, Anne, additional, Haibel, Hildrun, additional, Proft, Fabian, additional, Guerra, Gabriella Maria, additional, Durek, Pawel, additional, Heinrich, Frederik, additional, Gomes, Marta Ferreira, additional, Burmester, Gerd R., additional, Radbruch, Andreas, additional, Mashreghi, Mir-Farzin, additional, Lino, Andreia C., additional, and Dörner, Thomas, additional

Published
2021
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36. Typically asymptomatic but with robust antibody formation: Children’s unique humoral immune response to SARS-CoV-2

Author

Renk, Hanna, primary, Dulovic, Alex, additional, Becker, Matthias, additional, Fabricius, Dorit, additional, Zernickel, Maria, additional, Junker, Daniel, additional, Seidel, Alina, additional, Groß, Rüdiger, additional, Hilger, Alexander, additional, Bode, Sebastian, additional, Fritsch, Linus, additional, Frieh, Pauline, additional, Haddad, Anneke, additional, Görne, Tessa, additional, Remppis, Jonathan, additional, Ganzemueller, Tina, additional, Dietz, Andrea, additional, Huzly, Daniela, additional, Hengel, Hartmut, additional, Kaier, Klaus, additional, Weber, Susanne, additional, Jacobsen, Eva-Maria, additional, Kaiser, Philipp D., additional, Traenkle, Bjoern, additional, Rothbauer, Ulrich, additional, Stich, Maximilian, additional, Tönshoff, Burkhard, additional, Hoffmann, Georg F., additional, Müller, Barbara, additional, Ludwig, Carolin, additional, Jahrsdörfer, Bernd, additional, Schrezenmeier, Hubert, additional, Peter, Andreas, additional, Hörber, Sebastian, additional, Iftner, Thomas, additional, Münch, Jan, additional, Stamminger, Thomas, additional, Groß, Hans-Jürgen, additional, Wolkewitz, Martin, additional, Engel, Corinna, additional, Rizzi, Marta, additional, Henneke, Philipp, additional, Franz, Axel R., additional, Debatin, Klaus-Michael, additional, Schneiderhan-Marra, Nicole, additional, Janda, Ales, additional, and Elling, Roland, additional

Published
2021
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37. Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients

Author

Sattler, Arne, primary, Schrezenmeier, Eva, additional, Weber, Ulrike A., additional, Potekhin, Alexander, additional, Bachmann, Friederike, additional, Straub-Hohenbleicher, Henriette, additional, Budde, Klemens, additional, Storz, Elena, additional, Proß, Vanessa, additional, Bergmann, Yasmin, additional, Thole, Linda M.L., additional, Tizian, Caroline, additional, Hölsken, Oliver, additional, Diefenbach, Andreas, additional, Schrezenmeier, Hubert, additional, Jahrsdörfer, Bernd, additional, Zemojtel, Tomasz, additional, Jechow, Katharina, additional, Conrad, Christian, additional, Lukassen, Sören, additional, Stauch, Diana, additional, Lachmann, Nils, additional, Choi, Mira, additional, Halleck, Fabian, additional, and Kotsch, Katja, additional

Published
2021
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38. Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients

Author

Rincon-Arevalo, Hector, primary, Choi, Mira, additional, Stefanski, Ana-Luisa, additional, Halleck, Fabian, additional, Weber, Ulrike, additional, Szelinski, Franziska, additional, Jahrsdörfer, Bernd, additional, Schrezenmeier, Hubert, additional, Ludwig, Carolin, additional, Sattler, Arne, additional, Kotsch, Katja, additional, Potekhin, Alexander, additional, Chen, Yidan, additional, Burmester, Gerd R., additional, Eckardt, Kai-Uwe, additional, Guerra, Gabriela Maria, additional, Durek, Pawel, additional, Heinrich, Frederik, additional, Ferreira-Gomes, Marta, additional, Radbruch, Andreas, additional, Budde, Klemens, additional, Lino, Andreia C., additional, Mashreghi, Mir-Farzin, additional, Schrezenmeier, Eva, additional, and Dörner, Thomas, additional

Published
2021
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39. Characterization of the SARS-CoV-2 Neutralization Potential of COVID-19–Convalescent Donors

Author

Jahrsdörfer, Bernd, primary, Groß, Rüdiger, additional, Seidel, Alina, additional, Wettstein, Lukas, additional, Ludwig, Carolin, additional, Schwarz, Tatjana, additional, Körper, Sixten, additional, Rojewski, Markus, additional, Lotfi, Ramin, additional, Weinstock, Christoph, additional, Seifried, Erhard, additional, Corman, Victor Max, additional, Drosten, Christian, additional, Münch, Jan, additional, and Schrezenmeier, Hubert, additional

Published
2021
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40. Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity

Author

Groß, Rüdiger, primary, Zanoni, Michelle, additional, Seidel, Alina, additional, Conzelmann, Carina, additional, Gilg, Andrea, additional, Krnavek, Daniela, additional, Erdemci-Evin, Sümeyye, additional, Mayer, Benjamin, additional, Hoffmann, Markus, additional, Pöhlmann, Stefan, additional, Beil, Alexandra, additional, Kroschel, Joris, additional, Jahrsdörfer, Bernd, additional, Schrezenmeier, Hubert, additional, Kirchhoff, Frank, additional, Münch, Jan, additional, and Müller, Janis A., additional

Published
2021
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41. Real-World Data Suggest Effectiveness of Allogeneic Mesenchymal Stromal (MSC-FFM) Cells in Ruxolitinib-Refractory Acute Graft-Versus-Host Disease

Author

Bader, Peter, Verbeek, Mareike, Herhaus, Peter, Pachzelt, Lavinia, Beutel, Gernot, Schmid, Christoph, Müller, Nadine, Bug, Gesine, von Stackelberg, Arend, Tischer, Johanna, Ayuk, Francis A., Wulf, Gerald G., Pfeffermann, Lisa-Marie, Jahrsdörfer, Bernd, Schrezenmeier, Hubert, Kuci, Selim, Kuci, Zyrafete, Zens, Anke, Tribanek, Michael, Zeiser, Robert, Huenecke, Sabine, and Bonig, Halvard

Published
2023
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43. Persistent but atypical germinal center reaction among 3rd SARS-CoV-2 vaccination after rituximab exposure.

Author

Stefanski, Ana-Luisa, Rincon-Arevalo, Hector, Schrezenmeier, Eva, Karberg, Kirsten, Szelinski, Franziska, Ritter, Jacob, Yidan Chen, Meisel, Christian, Jahrsdörfer, Bernd, Ludwig, Carolin, Schrezenmeier, Hubert, Lino, Andreia C., and Dörner, Thomas

Subjects
GERMINAL centers, IMMUNOLOGIC memory, RITUXIMAB, VACCINATION, PLASMA cells, HYPERCOAGULATION disorders
Abstract

Background: Durable vaccine-mediated immunity relies on the generation of long-lived plasma cells and memory B cells (MBCs), differentiating upon germinal center (GC) reactions. SARS-CoV-2 mRNA vaccination induces a strong GC response in healthy volunteers (HC), but limited data is available about response longevity upon rituximab treatment. Methods: We evaluated humoral and cellular responses upon 3rd vaccination in seven patients with rheumatoid arthritis (RA) who initially mounted anti-spike SARS-CoV-2 IgG antibodies after primary 2x vaccination and got re-exposed to rituximab (RTX) 1-2 months after the second vaccination. Ten patients with RA on other therapies and ten HC represented the control groups. As control for known long-lived induced immunity, we analyzed humoral and cellular tetanus toxoid (TT) immune responses in steady-state. Results: After 3rd vaccination, 5/7 seroconverted RTX patients revealed lower anti-SARS-CoV-2 IgG levels but similar neutralizing capacity compared with HC. Antibody levels after 3rd vaccination correlated with values after 2nd vaccination. Despite significant reduction of circulating total and antigenspecific B cells in RTX re-exposed patients, we observed the induction of IgG+ MBCs upon 3rd vaccination. Notably, only RTX treated patients revealed a high amount of IgA+ MBCs before and IgA+ plasmablasts after 3rd vaccination. IgA+ B cells were not part of the steady state TT+ B cell pool. TNF-secretion and generation of effector memory CD4 spike-specific T cells were significantly boosted upon 3rd vaccination. Summary: On the basis of pre-existing affinity matured MBCs within primary immunisation, RTX re-exposed patients revealed a persistent but atypical GC immune response accompanied by boosted spike-specific memory CD4 T cells upon SARS-CoV-2 recall vaccination. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Impaired antigen-specific memory B cell and plasma cell responses including lack of specific IgG upon SARS-CoV-2 BNT162b2 vaccination among Kidney Transplant and Dialysis patients

Author

Rincon-Arevalo, Hector, primary, Choi, Mira, additional, Stefanski, Ana-Luisa, additional, Halleck, Fabian, additional, Weber, Ulrike, additional, Szelinski, Franziska, additional, Jahrsdörfer, Bernd, additional, Schrezenmeier, Hubert, additional, Ludwig, Carolin, additional, Sattler, Arne, additional, Kotsch, Katja, additional, Potekhin, Alexander, additional, Chen, Yidan, additional, Burmester, Gerd R., additional, Eckardt, Kai-Uwe, additional, Guerra, Gabriela Maria, additional, Durek, Pawel, additional, Heinrich, Frederik, additional, Ferreira-Gomes, Marta, additional, Radbruch, Andreas, additional, Budde, Klemens, additional, Lino, Andreia C., additional, Mashreghi, Mir-Farzin, additional, Schrezenmeier, Eva, additional, and Dörner, Thomas, additional

Published
2021
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45. Impaired Humoral and Cellular Immunity after SARS-CoV2 BNT162b2 (Tozinameran) Prime-Boost Vaccination in Kidney Transplant Recipients

Author

Sattler, Arne, primary, Schrezenmeier, Eva, additional, Weber, Ulrike, additional, Potekhin, Alexander, additional, Bachmann, Friederike, additional, Budde, Klemens, additional, Storz, Elena, additional, Proß, Vanessa, additional, Bergmann, Yasmin, additional, Thole, Linda, additional, Tizian, Caroline, additional, Hölsken, Oliver, additional, Diefenbach, Andreas, additional, Schrezenmeier, Hubert, additional, Jahrsdörfer, Bernd, additional, Zemojtel, Tomasz, additional, Jechow, Katharina, additional, Conrad, Christian, additional, Lukassen, Sören, additional, Stauch, Diana, additional, Lachmann, Nils, additional, Choi, Mira, additional, Halleck, Fabian, additional, and Kotsch, Katja, additional

Published
2021
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46. SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

Author

Hoffmann, Markus, primary, Arora, Prerna, additional, Groß, Rüdiger, additional, Seidel, Alina, additional, Hörnich, Bojan F., additional, Hahn, Alexander S., additional, Krüger, Nadine, additional, Graichen, Luise, additional, Hofmann-Winkler, Heike, additional, Kempf, Amy, additional, Winkler, Martin S., additional, Schulz, Sebastian, additional, Jäck, Hans-Martin, additional, Jahrsdörfer, Bernd, additional, Schrezenmeier, Hubert, additional, Müller, Martin, additional, Kleger, Alexander, additional, Münch, Jan, additional, and Pöhlmann, Stefan, additional

Published
2021
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47. SARS-CoV-2 variants B.1.351 and B.1.1.248: Escape from therapeutic antibodies and antibodies induced by infection and vaccination

Author

Hoffmann, Markus, primary, Arora, Prerna, additional, Groß, Rüdiger, additional, Seidel, Alina, additional, Hörnich, Bojan, additional, Hahn, Alexander, additional, Krüger, Nadine, additional, Graichen, Luise, additional, Hofmann-Winkler, Heike, additional, Kempf, Amy, additional, Winkler, Martin Sebastian, additional, Schulz, Sebastian, additional, Jäck, Hans-Martin, additional, Jahrsdörfer, Bernd, additional, Schrezenmeier, Hubert, additional, Müller, Martin, additional, Kleger, Alexander, additional, Münch, Jan, additional, and Pöhlmann, Stefan, additional

Published
2021
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48. Donors for SARS-CoV-2 Convalescent Plasma for a Controlled Clinical Trial: Donor Characteristics, Content and Time Course of SARS-CoV-2 Neutralizing Antibodies

Author

Körper, Sixten, primary, Jahrsdörfer, Bernd, additional, Corman, Victor M., additional, Pilch, Jan, additional, Wuchter, Patrick, additional, Blasczyk, Rainer, additional, Müller, Rebecca, additional, Tonn, Torsten, additional, Bakchoul, Tamam, additional, Schäfer, Richard, additional, Juhl, David, additional, Schwarz, Tatjana, additional, Gödecke, Nina, additional, Burkhardt, Thomas, additional, Schmidt, Michael, additional, Appl, Thomas, additional, Eichler, Hermann, additional, Klüter, Harald, additional, Drosten, Christian, additional, Seifried, Erhard, additional, and Schrezenmeier, Hubert, additional

Published
2021
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50. Independent Side-by-Side Validation and Comparison of 4 Serological Platforms for SARS-CoV-2 Antibody Testing

Author

Jahrsdörfer, Bernd, primary, Kroschel, Joris, additional, Ludwig, Carolin, additional, Corman, Victor Max, additional, Schwarz, Tatjana, additional, Körper, Sixten, additional, Rojewski, Markus, additional, Lotfi, Ramin, additional, Weinstock, Christof, additional, Drosten, Christian, additional, Seifried, Erhard, additional, Stamminger, Thomas, additional, Groß, Hans Jürgen, additional, and Schrezenmeier, Hubert, additional

Published
2020
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